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1: GO: Molecular Function [Display Chart] 512 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031492 nucleosomal DNA binding 6.180E-5 3.164E-2
2.157E-1
 3.164E-2 4 30

2: GO: Biological Process [Display Chart] 2838 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006337 nucleosome disassembly 7.876E-6 1.118E-2
9.532E-2
 2.235E-2 4 18
2 GO:0032986 protein-DNA complex disassembly 7.876E-6 1.118E-2
9.532E-2
 2.235E-2 4 18
3 GO:0031498 chromatin disassembly 1.233E-5 1.166E-2
9.947E-2
 3.499E-2 4 20

3: GO: Cellular Component [Display Chart] 344 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0090544 BAF-type complex 7.346E-7 2.216E-4 1.423E-3 2.527E-4 5 24
2 GO:0071564 npBAF complex 1.288E-6 2.216E-4 1.423E-3 4.432E-4 4 12
3 GO:0071565 nBAF complex 2.576E-6 2.403E-4 1.543E-3 8.861E-4 4 14
4 GO:0044427 chromosomal part 3.174E-6 2.403E-4 1.543E-3 1.092E-3 20 841
5 GO:0016514 SWI/SNF complex 3.493E-6 2.403E-4 1.543E-3 1.202E-3 4 15
6 GO:0070603 SWI/SNF superfamily-type complex 1.678E-5 8.425E-4 5.409E-3 5.771E-3 6 74
7 GO:0005694 chromosome 1.714E-5 8.425E-4 5.409E-3 5.898E-3 20 943
8 GO:0000785 chromatin 6.224E-5 2.676E-3 1.718E-2 2.141E-2 13 489
9 GO:1990904 ribonucleoprotein complex 1.212E-4 4.168E-3 2.676E-2 4.168E-2 16 751
10 GO:0030529 intracellular ribonucleoprotein complex 1.212E-4 4.168E-3 2.676E-2 4.168E-2 16 751
11 GO:0000790 nuclear chromatin 1.435E-4 4.489E-3 2.881E-2 4.938E-2 10 326
12 GO:0000228 nuclear chromosome 2.827E-4 8.104E-3
5.202E-2
9.725E-2
 13 570
13 GO:1990726 Lsm1-7-Pat1 complex 3.146E-4 8.326E-3
5.345E-2
1.082E-1
 2 4
14 GO:0044454 nuclear chromosome part 5.462E-4 1.342E-2
8.615E-2
1.879E-1
 12 533
15 GO:0046540 U4/U6 x U5 tri-snRNP complex 6.064E-4 1.391E-2
8.927E-2
2.086E-1
 3 23
16 GO:0097525 spliceosomal snRNP complex 6.490E-4 1.395E-2
8.957E-2
2.233E-1
 4 54
17 GO:0005730 nucleolus 8.321E-4 1.684E-2
1.081E-1
2.863E-1
 16 894
18 GO:0005688 U6 snRNP 1.085E-3 1.882E-2
1.208E-1
3.734E-1
 2 7
19 GO:0097526 spliceosomal tri-snRNP complex 1.092E-3 1.882E-2
1.208E-1
3.757E-1
 3 28
20 GO:0030532 small nuclear ribonucleoprotein complex 1.094E-3 1.882E-2
1.208E-1
3.765E-1
 4 62
21 GO:0000307 cyclin-dependent protein kinase holoenzyme complex 1.771E-3 2.901E-2
1.862E-1
6.093E-1
 3 33
Show 16 more annotations

4: Human Phenotype [Display Chart] 318 annotations before applied cutoff / 1813 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 2260 annotations before applied cutoff / 9208 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002398 abnormal bone marrow cell morphology/development 2.617E-6 5.914E-3 4.909E-2 5.914E-3 17 567
2 MP:0002123 abnormal definitive hematopoiesis 1.504E-5 1.187E-2
9.853E-2
 3.399E-2 21 940
3 MP:0006410 abnormal common myeloid progenitor cell morphology 1.751E-5 1.187E-2
9.853E-2
 3.956E-2 8 139
4 MP:0013693 abnormal hemopoiesis 2.282E-5 1.187E-2
9.853E-2
5.157E-2
 21 966
5 MP:0008973 decreased erythroid progenitor cell number 2.626E-5 1.187E-2
9.853E-2
5.935E-2
 6 72
6 MP:0001852 conjunctivitis 7.550E-5 2.796E-2
2.321E-1
1.706E-1
 4 28
7 MP:0013661 abnormal myeloid cell number 9.656E-5 2.796E-2
2.321E-1
2.182E-1
 14 532
8 MP:0004810 decreased hematopoietic stem cell number 9.899E-5 2.796E-2
2.321E-1
2.237E-1
 6 91
9 MP:0004953 decreased spleen weight 1.257E-4 3.158E-2
2.621E-1
2.842E-1
 6 95
10 MP:0000921 demyelination 1.669E-4 3.622E-2
3.007E-1
3.773E-1
 6 100
11 MP:0013659 abnormal erythroid lineage cell morphology 1.763E-4 3.622E-2
3.007E-1
3.984E-1
 18 864
12 MP:0000333 decreased bone marrow cell number 2.260E-4 3.939E-2
3.270E-1
5.107E-1
 7 150
13 MP:0010210 abnormal circulating cytokine level 2.266E-4 3.939E-2
3.270E-1
5.121E-1
 10 312
Show 8 more annotations

6: Domain [Display Chart] 733 annotations before applied cutoff / 16924 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR015453 CycA InterPro 5.900E-5 2.560E-2
1.837E-1
 4.325E-2 2 2
2 IPR014400 Cyclin A B D E InterPro 6.986E-5 2.560E-2
1.837E-1
5.120E-2
 3 11
3 PF02984 Cyclin C Pfam 1.883E-4 3.451E-2
2.476E-1
1.381E-1
 3 15
4 IPR004367 Cyclin C InterPro 1.883E-4 3.451E-2
2.476E-1
1.381E-1
 3 15

7: Pathway [Display Chart] 809 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 530733 Cell Cycle BioSystems: REACTOME 2.462E-6 1.885E-3 1.371E-2 1.992E-3 16 514
2 105765 Cell Cycle, Mitotic BioSystems: REACTOME 4.661E-6 1.885E-3 1.371E-2 3.771E-3 14 416
3 198884 TNF-alpha/NF-kB Signaling Pathway BioSystems: WikiPathways 2.473E-5 6.669E-3 4.851E-2 2.001E-2 9 196
4 105801 G2/M Transition BioSystems: REACTOME 4.127E-5 7.438E-3
5.410E-2
 3.339E-2 7 118
5 160942 Mitotic G2-G2/M phases BioSystems: REACTOME 4.597E-5 7.438E-3
5.410E-2
 3.719E-2 7 120
6 M3686 Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. MSigDB C2 BIOCARTA (v5.1) 1.320E-4 1.780E-2
1.295E-1
1.068E-1
 3 13
7 105803 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes BioSystems: REACTOME 1.874E-4 2.166E-2
1.575E-1
1.516E-1
 2 3
8 105808 Recruitment of mitotic centrosome proteins and complexes BioSystems: REACTOME 2.995E-4 2.692E-2
1.958E-1
2.423E-1
 5 74
9 105807 Centrosome maturation BioSystems: REACTOME 2.995E-4 2.692E-2
1.958E-1
2.423E-1
 5 74
10 198857 IL-7 Signaling Pathway BioSystems: WikiPathways 4.007E-4 3.241E-2
2.358E-1
3.241E-1
 4 44
11 105799 G2 Phase BioSystems: REACTOME 6.182E-4 4.459E-2
3.244E-1
5.002E-1
 2 5
12 105802 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 6.749E-4 4.459E-2
3.244E-1
5.460E-1
 3 22
13 M17770 Cyclins and Cell Cycle Regulation MSigDB C2 BIOCARTA (v5.1) 7.717E-4 4.459E-2
3.244E-1
6.243E-1
 3 23
14 137969 Signaling events mediated by PRL BioSystems: Pathway Interaction Database 7.717E-4 4.459E-2
3.244E-1
6.243E-1
 3 23
15 160941 Mitotic G1-G1/S phases BioSystems: REACTOME 8.296E-4 4.474E-2
3.254E-1
6.711E-1
 6 139
16 106542 Telomere Extension By Telomerase BioSystems: REACTOME 9.225E-4 4.665E-2
3.393E-1
7.463E-1
 2 6
Show 11 more annotations

8: Pubmed [Display Chart] 25651 annotations before applied cutoff / 51818 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19650111 Variations in the composition of mammalian SWI/SNF chromatin remodelling complexes. Pubmed 9.251E-13 1.657E-8 1.778E-7 2.373E-8 5 6
2 14743216 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Pubmed 1.292E-12 1.657E-8 1.778E-7 3.315E-8 11 162
3 25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Pubmed 3.470E-12 2.967E-8 3.183E-7 8.901E-8 19 849
4 23443559 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Pubmed 3.809E-11 1.976E-7 2.120E-6 9.770E-7 16 639
5 15985610 PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Pubmed 3.851E-11 1.976E-7 2.120E-6 9.878E-7 5 10
6 11078522 The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. Pubmed 1.205E-10 4.883E-7 5.239E-6 3.091E-6 5 12
7 15231748 Functional proteomics mapping of a human signaling pathway. Pubmed 1.332E-10 4.883E-7 5.239E-6 3.418E-6 15 591
8 16199878 Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. Pubmed 2.853E-10 9.149E-7 9.817E-6 7.319E-6 4 5
9 17643375 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Pubmed 1.186E-9 3.379E-6 3.626E-5 3.041E-5 12 390
10 20130577 CHD7 cooperates with PBAF to control multipotent neural crest formation. Pubmed 3.969E-9 1.018E-5 1.092E-4 1.018E-4 4 8
11 20467437 Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice. Pubmed 1.070E-8 2.053E-5 2.203E-4 2.744E-4 13 581
12 14729568 A methylation-mediator complex in hormone signaling. Pubmed 1.186E-8 2.053E-5 2.203E-4 3.041E-4 4 10
13 10078207 Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Pubmed 1.186E-8 2.053E-5 2.203E-4 3.041E-4 4 10
14 9845365 Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Pubmed 1.186E-8 2.053E-5 2.203E-4 3.041E-4 4 10
15 21532573 Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Pubmed 1.201E-8 2.053E-5 2.203E-4 3.080E-4 6 56
16 11018012 Functional selectivity of recombinant mammalian SWI/SNF subunits. Pubmed 1.859E-8 2.980E-5 3.198E-4 4.768E-4 4 11
17 16196087 Large-scale analysis of the human ubiquitin-related proteome. Pubmed 2.105E-8 3.003E-5 3.222E-4 5.401E-4 10 313
18 16199878:gr Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. GeneRIF 2.107E-8 3.003E-5 3.222E-4 5.406E-4 3 3
19 11734557 SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. Pubmed 2.782E-8 3.756E-5 4.030E-4 7.137E-4 4 12
20 11726552 Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Pubmed 4.010E-8 5.143E-5 5.519E-4 1.029E-3 4 13
21 21549307 Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Pubmed 4.246E-8 5.186E-5 5.564E-4 1.089E-3 7 117
22 18809673 BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. Pubmed 5.602E-8 6.248E-5 6.704E-4 1.437E-3 4 14
23 8804307 Diversity and specialization of mammalian SWI/SNF complexes. Pubmed 5.602E-8 6.248E-5 6.704E-4 1.437E-3 4 14
24 8895581 Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. Pubmed 7.623E-8 7.686E-5 8.247E-4 1.955E-3 4 15
25 19505873 Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. Pubmed 8.358E-8 7.686E-5 8.247E-4 2.144E-3 6 77
26 18401423 Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression. Pubmed 8.390E-8 7.686E-5 8.247E-4 2.152E-3 3 4
27 18401423:gr Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression. GeneRIF 8.390E-8 7.686E-5 8.247E-4 2.152E-3 3 4
28 15150092 The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization. Pubmed 8.390E-8 7.686E-5 8.247E-4 2.152E-3 3 4
29 16387653 ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Pubmed 1.210E-7 1.070E-4 1.148E-3 3.104E-3 5 42
30 21890473 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Pubmed 1.440E-7 1.231E-4 1.321E-3 3.694E-3 8 209
31 21903422 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Pubmed 1.570E-7 1.299E-4 1.394E-3 4.026E-3 9 294
32 14559996 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Pubmed 1.698E-7 1.320E-4 1.416E-3 4.355E-3 4 18
33 16217013 Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Pubmed 1.698E-7 1.320E-4 1.416E-3 4.355E-3 4 18
34 15014438 MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. Pubmed 2.093E-7 1.460E-4 1.566E-3 5.369E-3 3 5
35 12244326 Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Pubmed 2.093E-7 1.460E-4 1.566E-3 5.369E-3 3 5
36 16568092 Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt. Pubmed 2.093E-7 1.460E-4 1.566E-3 5.369E-3 3 5
37 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 2.106E-7 1.460E-4 1.566E-3 5.402E-3 10 401
38 20460684 Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. Pubmed 3.299E-7 2.227E-4 2.390E-3 8.463E-3 4 21
39 12368262 Identification of a polymorphic, neuron-specific chromatin remodeling complex. Pubmed 4.024E-7 2.492E-4 2.674E-3 1.032E-2 4 22
40 16940996 Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Pubmed 4.178E-7 2.492E-4 2.674E-3 1.072E-2 3 6
41 10943845 BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Pubmed 4.178E-7 2.492E-4 2.674E-3 1.072E-2 3 6
42 9584200 p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes. Pubmed 4.178E-7 2.492E-4 2.674E-3 1.072E-2 3 6
43 15314177 Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP. Pubmed 4.178E-7 2.492E-4 2.674E-3 1.072E-2 3 6
44 22681889 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Pubmed 4.418E-7 2.576E-4 2.764E-3 1.133E-2 13 803
45 26549023 The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. Pubmed 6.907E-7 3.937E-4 4.224E-3 1.772E-2 9 351
46 16601680 Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. Pubmed 7.296E-7 3.982E-4 4.272E-3 1.872E-2 3 7
47 19525936 BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Pubmed 7.296E-7 3.982E-4 4.272E-3 1.872E-2 3 7
48 20305087 A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Pubmed 9.541E-7 5.099E-4 5.471E-3 2.447E-2 5 63
49 25943894 1Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA. Pubmed 1.112E-6 5.820E-4 6.245E-3 2.852E-2 4 28
50 18042045 Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). Pubmed 1.165E-6 5.977E-4 6.413E-3 2.988E-2 3 8
Show 45 more annotations

9: Interaction [Display Chart] 4148 annotations before applied cutoff / 16535 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ARID2 ARID2 interactions 7.435E-8 3.084E-4 2.747E-3 3.084E-4 6 27
2 int:DPF3 DPF3 interactions 2.075E-6 4.304E-3 3.834E-2 8.608E-3 5 26
3 int:ACTL6A ACTL6A interactions 3.643E-6 5.037E-3 4.487E-2 1.511E-2 8 110
4 int:CPSF6 CPSF6 interactions 7.734E-6 6.460E-3
5.755E-2
 3.208E-2 7 87
5 int:SMARCA4 SMARCA4 interactions 7.787E-6 6.460E-3
5.755E-2
 3.230E-2 11 251
6 int:CHAF1A CHAF1A interactions 1.222E-5 7.473E-3
6.657E-2
5.067E-2
 10 215
7 int:KLF1 KLF1 interactions 1.261E-5 7.473E-3
6.657E-2
5.231E-2
 4 18
8 int:SNRPE SNRPE interactions 1.603E-5 8.311E-3
7.403E-2
6.648E-2
 6 65
9 int:RUNX1 RUNX1 interactions 1.938E-5 8.931E-3
7.955E-2
8.038E-2
 7 100
10 int:MEPCE MEPCE interactions 2.173E-5 9.015E-3
8.030E-2
9.015E-2
 9 183
11 int:HDAC4 HDAC4 interactions 2.778E-5 1.048E-2
9.332E-2
1.152E-1
 8 145
12 int:PBRM1 PBRM1 interactions 3.786E-5 1.309E-2
1.166E-1
1.571E-1
 5 46
13 int:ARID1B ARID1B interactions 4.209E-5 1.343E-2
1.196E-1
1.746E-1
 5 47
14 int:SLC27A2 SLC27A2 interactions 4.984E-5 1.416E-2
1.261E-1
2.067E-1
 4 25
15 int:SMARCD2 SMARCD2 interactions 5.163E-5 1.416E-2
1.261E-1
2.142E-1
 5 49
16 int:ING1 ING1 interactions 5.699E-5 1.416E-2
1.261E-1
2.364E-1
 5 50
17 int:PHF10 PHF10 interactions 5.852E-5 1.416E-2
1.261E-1
2.428E-1
 4 26
18 int:SMARCA2 SMARCA2 interactions 6.278E-5 1.416E-2
1.261E-1
2.604E-1
 7 120
19 int:KHSRP KHSRP interactions 6.484E-5 1.416E-2
1.261E-1
2.689E-1
 6 83
20 int:FBXW4 FBXW4 interactions 6.899E-5 1.431E-2
1.274E-1
2.862E-1
 5 52
21 int:POU5F1 POU5F1 interactions 8.338E-5 1.621E-2
1.444E-1
3.459E-1
 15 574
22 int:DPF1 DPF1 interactions 8.746E-5 1.621E-2
1.444E-1
3.628E-1
 3 11
23 int:NCOR1 NCOR1 interactions 9.707E-5 1.621E-2
1.444E-1
4.026E-1
 8 173
24 int:CHD7 CHD7 interactions 1.046E-4 1.621E-2
1.444E-1
4.337E-1
 4 30
25 int:SMARCC1 SMARCC1 interactions 1.092E-4 1.621E-2
1.444E-1
4.531E-1
 7 131
26 int:SMARCAD1 SMARCAD1 interactions 1.146E-4 1.621E-2
1.444E-1
4.752E-1
 7 132
27 int:BCLAF1 BCLAF1 interactions 1.153E-4 1.621E-2
1.444E-1
4.781E-1
 6 92
28 int:CSF1 CSF1 interactions 1.159E-4 1.621E-2
1.444E-1
4.808E-1
 3 12
29 int:HERC1 HERC1 interactions 1.193E-4 1.621E-2
1.444E-1
4.948E-1
 4 31
30 int:BCL7C BCL7C interactions 1.193E-4 1.621E-2
1.444E-1
4.948E-1
 4 31
31 int:MYC MYC interactions 1.212E-4 1.621E-2
1.444E-1
5.026E-1
 16 663
32 int:SMARCE1 SMARCE1 interactions 1.258E-4 1.631E-2
1.453E-1
5.220E-1
 7 134
33 int:TFAP4 TFAP4 interactions 1.298E-4 1.632E-2
1.454E-1
5.386E-1
 6 94
34 int:TFCP2L1 TFCP2L1 interactions 1.377E-4 1.679E-2
1.496E-1
5.710E-1
 6 95
35 int:STAT2 STAT2 interactions 1.531E-4 1.815E-2
1.617E-1
6.352E-1
 4 33
36 int:SMARCC2 SMARCC2 interactions 1.581E-4 1.821E-2
1.622E-1
6.557E-1
 7 139
37 int:NME7 NME7 interactions 1.869E-4 2.095E-2
1.867E-1
7.753E-1
 5 64
38 int:FBXO25 FBXO25 interactions 2.138E-4 2.333E-2
2.079E-1
8.867E-1
 8 194
39 int:RNF167 RNF167 interactions 2.354E-4 2.503E-2
2.230E-1
9.763E-1
 3 15
40 int:E2F1 E2F1 interactions 2.968E-4 3.075E-2
2.739E-1
1.000E0
 7 154
41 int:RELA RELA interactions 3.039E-4 3.075E-2
2.739E-1
1.000E0
 10 316
42 int:WRAP73 WRAP73 interactions 3.253E-4 3.138E-2
2.795E-1
1.000E0
 5 72
43 int:ARID1A ARID1A interactions 3.253E-4 3.138E-2
2.795E-1
1.000E0
 5 72
44 int:YWHAQ YWHAQ interactions 3.390E-4 3.196E-2
2.847E-1
1.000E0
 12 446
45 int:TERT TERT interactions 3.469E-4 3.198E-2
2.849E-1
1.000E0
 5 73
46 int:CDK4 CDK4 interactions 3.603E-4 3.249E-2
2.894E-1
1.000E0
 7 159
47 int:AKT1 AKT1 interactions 3.795E-4 3.349E-2
2.983E-1
1.000E0
 10 325
48 int:UBE2I UBE2I interactions 3.900E-4 3.370E-2
3.002E-1
1.000E0
 12 453
49 int:MKRN1 MKRN1 interactions 4.145E-4 3.509E-2
3.126E-1
1.000E0
 3 18
50 int:HUWE1 HUWE1 interactions 4.649E-4 3.706E-2
3.301E-1
1.000E0
 12 462
Show 45 more annotations

10: Cytoband [Display Chart] 126 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 466 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TMTCGCGANR UNKNOWN TMTCGCGANR UNKNOWN 7.510E-13 3.500E-10 2.353E-9 3.500E-10 14 109

12: Gene Family [Display Chart] 18 annotations before applied cutoff / 6751 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 AKAP A kinase (PRKA) anchor protein family genenames.org 3.903E-3 4.989E-2
1.744E-1
7.025E-2
 2 29
2 DNAJ DnaJ (Hsp40) homologs genenames.org 6.984E-3 4.989E-2
1.744E-1
1.257E-1
 2 39
3 UBE2 Ubiquitin-conjugating enzymes E2 genenames.org 1.130E-2 4.989E-2
1.744E-1
2.034E-1
 2 50
4 MXD MAX dimerization proteins genenames.org 1.940E-2 4.989E-2
1.744E-1
3.492E-1
 1 6
5 ZZZ Zinc fingers, ZZ-type genenames.org 1.940E-2 4.989E-2
1.744E-1
3.492E-1
 1 6
6 ZMYM Zinc fingers, MYM-type genenames.org 1.940E-2 4.989E-2
1.744E-1
3.492E-1
 1 6
7 ZBED Zinc fingers, BED-type genenames.org 1.940E-2 4.989E-2
1.744E-1
3.492E-1
 1 6
Show 2 more annotations

13: Coexpression [Display Chart] 5684 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4473 Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils. MSigDB C7: Immunologic Signatures (v5.1) 6.184E-6 1.758E-2
1.621E-1
 3.515E-2 9 200
2 GSE32986 CURDLAN HIGHDOSE VS GMCSF AND CURDLAN HIGHDOSE STIM DC DN Genes down-regulated in bone marrow-derived dendritic cells: high dose of 1,3-beta-D-oligoglucan [PubChem=11375554] versus CSF2 [GeneID=1437] and high dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v5.1) 6.184E-6 1.758E-2
1.621E-1
 3.515E-2 9 200
3 M11584 Down-regulated genes whose expression is associated with amplification of the 8q24 chromosome region in pancreatic cancer cell lines. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.150E-5 2.180E-2
2.010E-1
6.539E-2
 5 46
4 M10633 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.021E-5 2.711E-2
2.500E-1
2.285E-1
 7 143
5 M17742 Genes consistently up-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.393E-5 2.711E-2
2.500E-1
2.497E-1
 7 145
6 M5114 Genes up-regulated in comparison of CD4 [GeneID=920] dendritic cells (DC) versus CD4- [GeneID=920] CD8- DCs. MSigDB C7: Immunologic Signatures (v5.1) 4.770E-5 2.711E-2
2.500E-1
2.711E-1
 8 200
7 M6079 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (2h) versus IL4 [GeneID=3565] (2h). MSigDB C7: Immunologic Signatures (v5.1) 4.770E-5 2.711E-2
2.500E-1
2.711E-1
 8 200
8 GSE23308 CTRL VS CORTICOSTERONE TREATED MACROPHAGE MINERALCORTICOID REC KO DN Genes down-regulated in macrophages with NR3C2 [GeneID=4306] knockout: untreated versus corticosterone [PubChem=5839]. MSigDB C7: Immunologic Signatures (v5.1) 4.770E-5 2.711E-2
2.500E-1
2.711E-1
 8 200
9 M5950 Genes up-regulated during transplant rejection. MSigDB H: Hallmark Gene Sets (v5.1) 4.770E-5 2.711E-2
2.500E-1
2.711E-1
 8 200
10 M3177 Genes down-regulated in plasma cells versus memory B cells. MSigDB C7: Immunologic Signatures (v5.1) 4.770E-5 2.711E-2
2.500E-1
2.711E-1
 8 200
Show 5 more annotations

14: Coexpression Atlas [Display Chart] 2330 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 All Mouse Lung E14.5 Epithelial top 500 Lungmap Mouse Single Cell (Lungmap.net) 4.145E-7 9.658E-4 8.046E-3 9.658E-4 15 446
2 Lungmap Mouse e14.5 Epithelial (GSE52583) Top 500 Cluster 4 Mouse Lung E14.5 Epithelial top 500 c4 Lungmap Mouse Single Cell (Lungmap.net) 1.179E-5 1.373E-2
1.144E-1
 2.747E-2 7 112

15: Computational [Display Chart] 494 annotations before applied cutoff / 9399 genes in category

No results to display

16: MicroRNA [Display Chart] 1927 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 17276 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D004365 Drugs, Chinese Herbal CTD 3.284E-6 2.359E-2
2.437E-1
5.673E-2
 15 563
2 1599 UP Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; HL60; HG-U133A Broad Institute CMAP 4.440E-6 2.359E-2
2.437E-1
7.670E-2
 9 194
3 C027869 lingzhi CTD 4.534E-6 2.359E-2
2.437E-1
7.833E-2
 4 18
4 1387 DN Picotamide monohydrate [80530-63-8]; Down 200; 10.2uM; HL60; HG-U133A Broad Institute CMAP 5.461E-6 2.359E-2
2.437E-1
9.434E-2
 9 199
5 CID000119307 ginsenoside Rh2 Stitch 9.800E-6 3.386E-2
3.499E-1
1.693E-1
 5 45
6 CID004627201 AC1NDK7X Stitch 2.003E-5 4.620E-2
4.774E-1
3.461E-1
 6 87
7 MESH:D008175/C013592-T Lung Neoplasms affected by mangiferin CTD Therapeutic 2.077E-5 4.620E-2
4.774E-1
3.588E-1
 3 9
8 D013467 Sulindac CTD 2.443E-5 4.620E-2
4.774E-1
4.221E-1
 14 587
9 CID003003140 AC1MHEOC Stitch 2.887E-5 4.620E-2
4.774E-1
4.988E-1
 4 28
10 CID000100017 nimbolide Stitch 2.953E-5 4.620E-2
4.774E-1
5.102E-1
 3 10
11 1059 UP Rapamycin; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 3.317E-5 4.620E-2
4.774E-1
5.731E-1
 8 192
12 1854 DN Betazole hydrochloride; Down 200; 27uM; HL60; HT HG-U133A Broad Institute CMAP 3.841E-5 4.620E-2
4.774E-1
6.636E-1
 8 196
13 CID006438325 AC1O5PH2 Stitch 4.057E-5 4.620E-2
4.774E-1
7.009E-1
 5 60
14 2943 DN Asiaticoside [16830-15-2]; Down 200; 4.2uM; HL60; HT HG-U133A Broad Institute CMAP 4.128E-5 4.620E-2
4.774E-1
7.132E-1
 8 198
15 1705 UP Dapsone [80-08-0]; Up 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP 4.278E-5 4.620E-2
4.774E-1
7.391E-1
 8 199
16 1936 UP Edrophonium chloride [116-38-1]; Up 200; 19.8uM; PC3; HG-U133A Broad Institute CMAP 4.278E-5 4.620E-2
4.774E-1
7.391E-1
 8 199
Show 11 more annotations

18: Disease [Display Chart] 2398 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C3839280 High grade serous carcinoma DisGeNET BeFree 1.308E-5 2.481E-2
2.074E-1
 3.136E-2 4 22
2 umls:C0032131 Plasmacytoma DisGeNET BeFree 2.667E-5 2.481E-2
2.074E-1
6.395E-2
 6 87
3 umls:C1302773 Low Grade Squamous Intraepithelial Neoplasia DisGeNET BeFree 3.104E-5 2.481E-2
2.074E-1
7.443E-2
 5 54
4 umls:C0521158 Recurrent tumor DisGeNET BeFree 6.104E-5 2.991E-2
2.501E-1
1.464E-1
 10 320
5 umls:C0205748 Dysplastic Nevus DisGeNET BeFree 7.093E-5 2.991E-2
2.501E-1
1.701E-1
 5 64
6 umls:C1333280 Desmoplastic melanoma DisGeNET BeFree 8.142E-5 2.991E-2
2.501E-1
1.953E-1
 3 13
7 umls:C0007140 Carcinosarcoma DisGeNET Curated 8.749E-5 2.991E-2
2.501E-1
2.098E-1
 4 35
8 umls:C0349639 Juvenile Myelomonocytic Leukemia DisGeNET Curated 9.979E-5 2.991E-2
2.501E-1
2.393E-1
 6 110
9 umls:C3551915 MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO DisGeNET Curated 1.348E-4 3.592E-2
3.003E-1
3.233E-1
 2 3
10 umls:C0005411 Biliary Atresia DisGeNET Curated 1.612E-4 3.866E-2
3.232E-1
3.866E-1
 5 76
11 umls:C0333875 High-Grade Squamous Intraepithelial Lesions DisGeNET BeFree 2.440E-4 4.994E-2
4.175E-1
5.852E-1
 5 83
12 umls:C1332922 Cervical Squamous Intraepithelial Neoplasia DisGeNET BeFree 2.684E-4 4.994E-2
4.175E-1
6.437E-1
 2 4
13 umls:C0023473 Myeloid Leukemia, Chronic DisGeNET Curated 2.707E-4 4.994E-2
4.175E-1
6.492E-1
 15 791
Show 8 more annotations