Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc107_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 140 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008237 metallopeptidase activity 1.186E-7 1.661E-5 9.171E-5 1.661E-5 5 188
2 GO:0008238 exopeptidase activity 8.738E-7 6.117E-5 3.378E-4 1.223E-4 4 113
3 GO:0008241 peptidyl-dipeptidase activity 1.343E-6 6.270E-5 3.462E-4 1.881E-4 2 3
4 GO:0004180 carboxypeptidase activity 2.773E-6 9.704E-5 5.359E-4 3.882E-4 3 41
5 GO:0008235 metalloexopeptidase activity 6.064E-6 1.698E-4 9.376E-4 8.489E-4 3 53
6 GO:0005179 hormone activity 7.801E-5 1.820E-3 1.005E-2 1.092E-2 3 124
7 GO:0004181 metallocarboxypeptidase activity 1.557E-4 3.114E-3 1.720E-2 2.180E-2 2 27
8 GO:0004175 endopeptidase activity 2.129E-4 3.726E-3 2.058E-2 2.981E-2 4 457
9 GO:0017080 sodium channel regulator activity 2.482E-4 3.861E-3 2.132E-2 3.475E-2 2 34
10 GO:0030545 receptor regulator activity 5.603E-4 7.844E-3 4.332E-2
7.844E-2
 2 51
11 GO:0031861 prolactin-releasing peptide receptor binding 6.966E-4 8.127E-3 4.488E-2
9.753E-2
 1 1
12 GO:0031703 type 2 angiotensin receptor binding 6.966E-4 8.127E-3 4.488E-2
9.753E-2
 1 1
13 GO:0001664 G protein-coupled receptor binding 8.201E-4 8.832E-3 4.877E-2
1.148E-1
 3 276
14 GO:0017082 mineralocorticoid receptor activity 1.393E-3 1.292E-2
7.136E-2
1.950E-1
 1 2
15 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity 1.393E-3 1.292E-2
7.136E-2
1.950E-1
 1 2
16 GO:0042562 hormone binding 1.477E-3 1.292E-2
7.136E-2
2.067E-1
 2 83
17 GO:0004867 serine-type endopeptidase inhibitor activity 1.969E-3 1.462E-2
8.074E-2
2.756E-1
 2 96
18 GO:0008240 tripeptidyl-peptidase activity 2.089E-3 1.462E-2
8.074E-2
2.924E-1
 1 3
19 GO:0031711 bradykinin receptor binding 2.089E-3 1.462E-2
8.074E-2
2.924E-1
 1 3
20 GO:0070573 metallodipeptidase activity 2.089E-3 1.462E-2
8.074E-2
2.924E-1
 1 3
21 GO:0005496 steroid binding 2.262E-3 1.508E-2
8.327E-2
3.166E-1
 2 103
22 GO:0004222 metalloendopeptidase activity 2.714E-3 1.727E-2
9.538E-2
3.800E-1
 2 113
23 GO:0016176 superoxide-generating NADPH oxidase activator activity 3.479E-3 1.948E-2
1.076E-1
4.870E-1
 1 5
24 GO:0031404 chloride ion binding 3.479E-3 1.948E-2
1.076E-1
4.870E-1
 1 5
25 GO:0004945 angiotensin type II receptor activity 3.479E-3 1.948E-2
1.076E-1
4.870E-1
 1 5
26 GO:0016247 channel regulator activity 4.072E-3 2.087E-2
1.152E-1
5.700E-1
 2 139
27 GO:0019871 sodium channel inhibitor activity 4.173E-3 2.087E-2
1.152E-1
5.842E-1
 1 6
28 GO:0001595 angiotensin receptor activity 4.173E-3 2.087E-2
1.152E-1
5.842E-1
 1 6
29 GO:0019870 potassium channel inhibitor activity 5.561E-3 2.684E-2
1.482E-1
7.785E-1
 1 8
30 GO:0004866 endopeptidase inhibitor activity 6.093E-3 2.844E-2
1.570E-1
8.531E-1
 2 171
31 GO:0061135 endopeptidase regulator activity 6.515E-3 2.860E-2
1.580E-1
9.120E-1
 2 177
32 GO:0030414 peptidase inhibitor activity 6.730E-3 2.860E-2
1.580E-1
9.422E-1
 2 180
33 GO:0031702 type 1 angiotensin receptor binding 6.946E-3 2.860E-2
1.580E-1
9.725E-1
 1 10
34 GO:0048019 receptor antagonist activity 6.946E-3 2.860E-2
1.580E-1
9.725E-1
 1 10
35 GO:0031701 angiotensin receptor binding 8.330E-3 3.272E-2
1.807E-1
1.000E0
 1 12
36 GO:0030547 receptor inhibitor activity 9.712E-3 3.272E-2
1.807E-1
1.000E0
 1 14
37 GO:0061134 peptidase regulator activity 1.008E-2 3.272E-2
1.807E-1
1.000E0
 2 222
38 GO:0016805 dipeptidase activity 1.109E-2 3.272E-2
1.807E-1
1.000E0
 1 16
39 GO:0048018 receptor ligand activity 1.178E-2 3.272E-2
1.807E-1
1.000E0
 1 17
40 GO:0051428 peptide hormone receptor binding 1.178E-2 3.272E-2
1.807E-1
1.000E0
 1 17
41 GO:0008236 serine-type peptidase activity 1.189E-2 3.272E-2
1.807E-1
1.000E0
 2 242
42 GO:0017171 serine hydrolase activity 1.217E-2 3.272E-2
1.807E-1
1.000E0
 2 245
43 GO:0031434 mitogen-activated protein kinase kinase binding 1.316E-2 3.272E-2
1.807E-1
1.000E0
 1 19
44 GO:0044654 starch alpha-glucosidase activity 1.522E-2 3.272E-2
1.807E-1
1.000E0
 1 22
45 GO:0052736 beta-glucanase activity 1.522E-2 3.272E-2
1.807E-1
1.000E0
 1 22
46 GO:0052859 glucan endo-1,4-beta-glucosidase activity 1.522E-2 3.272E-2
1.807E-1
1.000E0
 1 22
47 GO:0052769 beta-6-sulfate-N-acetylglucosaminidase activity 1.522E-2 3.272E-2
1.807E-1
1.000E0
 1 22
48 GO:0044653 dextrin alpha-glucosidase activity 1.522E-2 3.272E-2
1.807E-1
1.000E0
 1 22
49 GO:0042277 peptide binding 1.548E-2 3.272E-2
1.807E-1
1.000E0
 2 278
50 GO:0034831 (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 1.591E-2 3.272E-2
1.807E-1
1.000E0
 1 23
Show 45 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 921 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001990 regulation of systemic arterial blood pressure by hormone 5.900E-16 3.845E-13 2.846E-12 5.434E-13 7 46
2 GO:0003073 regulation of systemic arterial blood pressure 8.349E-16 3.845E-13 2.846E-12 7.689E-13 8 103
3 GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 2.200E-15 5.137E-13 3.803E-12 2.026E-12 6 22
4 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 2.231E-15 5.137E-13 3.803E-12 2.055E-12 7 55
5 GO:0002003 angiotensin maturation 3.180E-14 4.996E-12 3.698E-11 2.929E-11 5 11
6 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 3.255E-14 4.996E-12 3.698E-11 2.997E-11 6 33
7 GO:0002002 regulation of angiotensin levels in blood 8.853E-14 1.165E-11 8.623E-11 8.153E-11 5 13
8 GO:0060177 regulation of angiotensin metabolic process 1.377E-13 1.585E-11 1.173E-10 1.268E-10 5 14
9 GO:0008217 regulation of blood pressure 1.672E-13 1.711E-11 1.267E-10 1.540E-10 8 197
10 GO:0050886 endocrine process 2.149E-13 1.979E-11 1.465E-10 1.979E-10 7 103
11 GO:0016486 peptide hormone processing 1.376E-11 1.152E-9 8.528E-9 1.267E-8 5 32
12 GO:0002016 regulation of blood volume by renin-angiotensin 1.017E-10 7.804E-9 5.778E-8 9.365E-8 4 13
13 GO:0006883 cellular sodium ion homeostasis 1.037E-9 6.990E-8 5.175E-7 9.548E-7 4 22
14 GO:1903596 regulation of gap junction assembly 1.062E-9 6.990E-8 5.175E-7 9.785E-7 3 4
15 GO:0002035 brain renin-angiotensin system 1.485E-8 9.118E-7 6.751E-6 1.368E-5 3 8
16 GO:0016485 protein processing 5.271E-8 2.980E-6 2.206E-5 4.855E-5 6 338
17 GO:0055078 sodium ion homeostasis 5.523E-8 2.980E-6 2.206E-5 5.086E-5 4 57
18 GO:0016264 gap junction assembly 5.825E-8 2.980E-6 2.206E-5 5.365E-5 3 12
19 GO:0051604 protein maturation 8.449E-8 4.096E-6 3.032E-5 7.781E-5 6 366
20 GO:1901888 regulation of cell junction assembly 1.351E-7 6.222E-6 4.606E-5 1.244E-4 4 71
21 GO:0042445 hormone metabolic process 1.982E-7 8.694E-6 6.436E-5 1.826E-4 5 208
22 GO:0007588 excretion 2.192E-7 9.175E-6 6.792E-5 2.019E-4 4 80
23 GO:0042311 vasodilation 2.800E-7 1.121E-5 8.302E-5 2.579E-4 4 85
24 GO:0003084 positive regulation of systemic arterial blood pressure 3.009E-7 1.155E-5 8.547E-5 2.771E-4 3 20
25 GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure 4.061E-7 1.496E-5 1.108E-4 3.740E-4 3 22
26 GO:0007043 cell-cell junction assembly 4.386E-7 1.554E-5 1.150E-4 4.039E-4 4 95
27 GO:0030004 cellular monovalent inorganic cation homeostasis 6.815E-7 2.325E-5 1.721E-4 6.276E-4 4 106
28 GO:0060047 heart contraction 8.053E-7 2.646E-5 1.959E-4 7.416E-4 5 276
29 GO:0003015 heart process 8.494E-7 2.646E-5 1.959E-4 7.823E-4 5 279
30 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 8.618E-7 2.646E-5 1.959E-4 7.937E-4 3 28
31 GO:1903598 positive regulation of gap junction assembly 1.349E-6 3.882E-5 2.874E-4 1.242E-3 2 3
32 GO:0003051 angiotensin-mediated drinking behavior 1.349E-6 3.882E-5 2.874E-4 1.242E-3 2 3
33 GO:0007631 feeding behavior 1.795E-6 5.010E-5 3.709E-4 1.653E-3 4 135
34 GO:0043271 negative regulation of ion transport 2.387E-6 6.466E-5 4.787E-4 2.199E-3 4 145
35 GO:0044256 protein digestion 2.697E-6 6.713E-5 4.970E-4 2.484E-3 2 4
36 GO:0002018 renin-angiotensin regulation of aldosterone production 2.697E-6 6.713E-5 4.970E-4 2.484E-3 2 4
37 GO:0002019 regulation of renal output by angiotensin 2.697E-6 6.713E-5 4.970E-4 2.484E-3 2 4
38 GO:0055067 monovalent inorganic cation homeostasis 3.360E-6 8.144E-5 6.029E-4 3.095E-3 4 158
39 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway 4.493E-6 1.061E-4 7.855E-4 4.138E-3 2 5
40 GO:0050880 regulation of blood vessel size 5.042E-6 1.131E-4 8.373E-4 4.644E-3 4 175
41 GO:0045777 positive regulation of blood pressure 5.111E-6 1.131E-4 8.373E-4 4.707E-3 3 50
42 GO:0035150 regulation of tube size 5.157E-6 1.131E-4 8.373E-4 4.750E-3 4 176
43 GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger 6.737E-6 1.379E-4 1.021E-3 6.205E-3 2 6
44 GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure 6.737E-6 1.379E-4 1.021E-3 6.205E-3 2 6
45 GO:0002034 regulation of blood vessel diameter by renin-angiotensin 6.737E-6 1.379E-4 1.021E-3 6.205E-3 2 6
46 GO:0001974 blood vessel remodeling 8.020E-6 1.606E-4 1.189E-3 7.386E-3 3 58
47 GO:0034329 cell junction assembly 8.556E-6 1.670E-4 1.236E-3 7.880E-3 4 200
48 GO:0003018 vascular process in circulatory system 8.899E-6 1.670E-4 1.236E-3 8.196E-3 4 202
49 GO:2000858 regulation of aldosterone secretion 9.428E-6 1.670E-4 1.236E-3 8.683E-3 2 7
50 GO:0035931 mineralocorticoid secretion 9.428E-6 1.670E-4 1.236E-3 8.683E-3 2 7
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 8 input genes in category / 427 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008660 Renotubular dysgenesis 1.514E-5 6.466E-3 4.290E-2 6.466E-3 2 4
2 HP:0002855 Abnormality of aldosterone production 5.725E-5 8.149E-3
5.407E-2
 2.445E-2 3 49
3 HP:0000859 Hyperaldosteronism 5.725E-5 8.149E-3
5.407E-2
 2.445E-2 3 49
4 HP:0002717 Adrenal overactivity 1.467E-4 1.208E-2
8.015E-2
6.265E-2
 3 67
5 HP:0003351 Decreased circulating renin level 1.654E-4 1.208E-2
8.015E-2
7.064E-2
 2 12
6 HP:0000848 Increased circulating renin level 2.625E-4 1.208E-2
8.015E-2
1.121E-1
 2 15
7 HP:0002009 Potter facies 2.625E-4 1.208E-2
8.015E-2
1.121E-1
 2 15
8 HP:0011334 Facial shape deformation 2.625E-4 1.208E-2
8.015E-2
1.121E-1
 2 15
9 HP:0100519 Anuria 2.625E-4 1.208E-2
8.015E-2
1.121E-1
 2 15
10 HP:0002924 Decreased circulating aldosterone level 2.998E-4 1.208E-2
8.015E-2
1.280E-1
 2 16
11 HP:0040085 Abnormal circulating aldosterone 3.395E-4 1.208E-2
8.015E-2
1.449E-1
 2 17
12 HP:0004492 Widely patent fontanelles and sutures 3.395E-4 1.208E-2
8.015E-2
1.449E-1
 2 17
13 HP:0000849 Adrenocortical abnormality 4.275E-4 1.404E-2
9.318E-2
1.826E-1
 3 96
14 HP:0003350 Abnormality of the renin-aldosterone axis 5.741E-4 1.751E-2
1.162E-1
2.452E-1
 2 22
15 HP:0010537 Wide cranial sutures 6.283E-4 1.788E-2
1.187E-1
2.683E-1
 2 23
16 HP:0040084 Abnormal circulating renin 6.848E-4 1.828E-2
1.213E-1
2.924E-1
 2 24
17 HP:0011037 Decreased urine output 8.050E-4 2.022E-2
1.342E-1
3.437E-1
 2 26
18 HP:0000847 Abnormality of renin-angiotensin system 1.222E-3 2.900E-2
1.924E-1
5.219E-1
 2 32
Show 13 more annotations

5: Mouse Phenotype [Display Chart] 13 input genes in category / 845 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011415 abnormal aldosterone level 1.369E-11 1.157E-8 8.464E-8 1.157E-8 6 49
2 MP:0000230 abnormal systemic arterial blood pressure 8.528E-9 3.603E-6 2.636E-5 7.206E-6 7 259
3 MP:0002842 increased systemic arterial blood pressure 1.944E-8 5.477E-6 4.007E-5 1.643E-5 6 160
4 MP:0004857 abnormal heart weight 4.466E-8 9.435E-6 6.904E-5 3.774E-5 7 329
5 MP:0001762 polyuria 8.304E-8 1.215E-5 8.889E-5 7.017E-5 5 98
6 MP:0006373 abnormal circulating angiotensinogen level 8.626E-8 1.215E-5 8.889E-5 7.289E-5 3 8
7 MP:0003372 abnormal circulating mineralocorticoid level 1.794E-7 1.894E-5 1.386E-4 1.516E-4 4 43
8 MP:0005346 abnormal circulating aldosterone level 1.794E-7 1.894E-5 1.386E-4 1.516E-4 4 43
9 MP:0002843 decreased systemic arterial blood pressure 2.297E-7 2.157E-5 1.578E-4 1.941E-4 5 120
10 MP:0011978 abnormal potassium ion homeostasis 3.562E-7 3.010E-5 2.202E-4 3.010E-4 5 131
11 MP:0009643 abnormal urine homeostasis 5.286E-7 4.061E-5 2.971E-4 4.467E-4 7 472
12 MP:0006274 abnormal urine sodium level 8.537E-7 6.012E-5 4.399E-4 7.214E-4 4 63
13 MP:0001756 abnormal urination 1.089E-6 6.774E-5 4.956E-4 9.202E-4 5 164
14 MP:0011977 abnormal sodium ion homeostasis 1.122E-6 6.774E-5 4.956E-4 9.483E-4 5 165
15 MP:0000231 hypertension 1.234E-6 6.951E-5 5.086E-4 1.043E-3 4 69
16 MP:0003352 increased circulating renin level 1.481E-6 7.820E-5 5.722E-4 1.251E-3 3 19
17 MP:0011541 decreased urine aldosterone level 4.362E-6 2.168E-4 1.586E-3 3.686E-3 2 3
18 MP:0003349 abnormal circulating renin level 5.543E-6 2.602E-4 1.904E-3 4.684E-3 3 29
19 MP:0011941 increased fluid intake 5.927E-6 2.603E-4 1.905E-3 5.008E-3 4 102
20 MP:0002834 decreased heart weight 6.162E-6 2.603E-4 1.905E-3 5.207E-3 4 103
21 MP:0003638 abnormal response/metabolism to endogenous compounds 8.602E-6 3.203E-4 2.344E-3 7.269E-3 4 112
22 MP:0011539 abnormal urine aldosterone level 8.718E-6 3.203E-4 2.344E-3 7.366E-3 2 4
23 MP:0006376 decreased circulating angiotensinogen level 8.718E-6 3.203E-4 2.344E-3 7.366E-3 2 4
24 MP:0020148 abnormal sensitivity to induced morbidity/mortality 1.015E-5 3.458E-4 2.531E-3 8.579E-3 6 463
25 MP:0006319 abnormal epididymal fat pad morphology 1.023E-5 3.458E-4 2.531E-3 8.646E-3 4 117
26 MP:0000519 hydronephrosis 1.208E-5 3.926E-4 2.873E-3 1.021E-2 4 122
27 MP:0006375 increased circulating angiotensinogen level 1.452E-5 4.409E-4 3.226E-3 1.227E-2 2 5
28 MP:0011947 abnormal fluid intake 1.461E-5 4.409E-4 3.226E-3 1.235E-2 4 128
29 MP:0002703 abnormal renal tubule morphology 1.694E-5 4.859E-4 3.556E-3 1.431E-2 5 287
30 MP:0004820 abnormal urine potassium level 1.725E-5 4.859E-4 3.556E-3 1.458E-2 3 42
31 MP:0004194 abnormal kidney pelvis morphology 2.456E-5 6.696E-4 4.899E-3 2.076E-2 4 146
32 MP:0001422 abnormal drinking behavior 2.878E-5 7.601E-4 5.562E-3 2.432E-2 4 152
33 MP:0011538 abnormal urine hormone level 3.045E-5 7.727E-4 5.654E-3 2.573E-2 2 7
34 MP:0006264 decreased systemic arterial systolic blood pressure 3.109E-5 7.727E-4 5.654E-3 2.627E-2 3 51
35 MP:0009763 increased sensitivity to induced morbidity/mortality 4.291E-5 1.036E-3 7.580E-3 3.626E-2 5 348
36 MP:0005333 decreased heart rate 4.676E-5 1.097E-3 8.030E-3 3.951E-2 4 172
37 MP:0005524 abnormal renal plasma flow rate 5.212E-5 1.159E-3 8.481E-3 4.404E-2 2 9
38 MP:0011304 kidney papillary atrophy 5.212E-5 1.159E-3 8.481E-3 4.404E-2 2 9
39 MP:0004970 kidney atrophy 6.456E-5 1.399E-3 1.023E-2
5.455E-2
 3 65
40 MP:0002988 decreased urine osmolality 7.070E-5 1.494E-3 1.093E-2
5.974E-2
 3 67
41 MP:0011422 kidney medulla atrophy 7.952E-5 1.639E-3 1.199E-2
6.719E-2
 2 11
42 MP:0000249 abnormal blood vessel physiology 1.065E-4 2.106E-3 1.541E-2
8.999E-2
 5 421
43 MP:0002987 abnormal urine osmolality 1.072E-4 2.106E-3 1.541E-2
9.056E-2
 3 77
44 MP:0005582 increased renin activity 1.313E-4 2.465E-3 1.804E-2
1.109E-1
 2 14
45 MP:0011423 kidney cortex atrophy 1.313E-4 2.465E-3 1.804E-2
1.109E-1
 2 14
46 MP:0002833 increased heart weight 1.600E-4 2.938E-3 2.150E-2
1.352E-1
 4 236
47 MP:0011309 abnormal kidney arterial blood vessel morphology 1.729E-4 3.108E-3 2.274E-2
1.461E-1
 2 16
48 MP:0000010 abnormal abdominal fat pad morphology 2.091E-4 3.681E-3 2.694E-2
1.767E-1
 4 253
49 MP:0003374 decreased circulating mineralocorticoid level 2.201E-4 3.720E-3 2.722E-2
1.860E-1
 2 18
50 MP:0002667 decreased circulating aldosterone level 2.201E-4 3.720E-3 2.722E-2
1.860E-1
 2 18
Show 45 more annotations

6: Domain [Display Chart] 13 input genes in category / 90 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01401 Peptidase M2 Pfam 4.445E-7 2.184E-5 1.110E-4 4.000E-5 2 2
2 PS00142 ZINC PROTEASE PROSITE 4.854E-7 2.184E-5 1.110E-4 4.369E-5 4 98
3 IPR001548 Peptidase M2 InterPro 1.333E-6 3.999E-5 2.032E-4 1.200E-4 2 3
4 IPR029727 MME/CD10/NEP InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
5 IPR033834 Angiotensinogen serpin InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
6 IPR033591 ACE2 InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
7 PF15172 Prolactin RP Pfam 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
8 IPR028707 Matrilysin InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
9 IPR029712 ALP InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
10 IPR000147 ATII AT2 rcpt InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
11 IPR000227 Angiotensinogen InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
12 IPR026194 PrRP InterPro 6.939E-4 5.204E-3 2.645E-2
6.245E-2
 1 1
13 IPR031588 Collectrin dom InterPro 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
14 PS00335 PARATHYROID PROSITE 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
15 IPR001415 PTH/PTH-rel InterPro 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
16 PF16959 Collectrin Pfam 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
17 PF01279 Parathyroid Pfam 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
18 SM00087 PTH SMART 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
19 IPR003626 PTH-rel InterPro 1.387E-3 5.984E-3 3.041E-2
1.249E-1
 1 2
20 3.40.390.10 - Gene3D 1.396E-3 5.984E-3 3.041E-2
1.257E-1
 2 81
21 IPR024079 MetalloPept cat dom InterPro 1.396E-3 5.984E-3 3.041E-2
1.257E-1
 2 81
22 IPR001186 Brdyknn 1 rcpt InterPro 2.080E-3 8.510E-3 4.325E-2
1.872E-1
 1 3
23 IPR000248 ATII rcpt InterPro 3.465E-3 1.356E-2
6.891E-2
3.119E-1
 1 5
24 PF01431 Peptidase M13 Pfam 4.848E-3 1.558E-2
7.920E-2
4.363E-1
 1 7
25 IPR000718 Peptidase M13 InterPro 4.848E-3 1.558E-2
7.920E-2
4.363E-1
 1 7
26 IPR018497 Peptidase M13 C InterPro 4.848E-3 1.558E-2
7.920E-2
4.363E-1
 1 7
27 PF05649 Peptidase M13 N Pfam 4.848E-3 1.558E-2
7.920E-2
4.363E-1
 1 7
28 IPR008753 Peptidase M13 N InterPro 4.848E-3 1.558E-2
7.920E-2
4.363E-1
 1 7
29 PF02244 Propep M14 Pfam 5.539E-3 1.608E-2
8.173E-2
4.985E-1
 1 8
30 IPR003146 M14A act pep InterPro 5.539E-3 1.608E-2
8.173E-2
4.985E-1
 1 8
31 3.30.70.340 - Gene3D 5.539E-3 1.608E-2
8.173E-2
4.985E-1
 1 8
32 IPR000324 VitD rcpt InterPro 9.674E-3 2.721E-2
1.383E-1
8.707E-1
 1 14
33 IPR021158 Pept M10A Zn BS InterPro 1.036E-2 2.780E-2
1.413E-1
9.326E-1
 1 15
34 PF00095 WAP Pfam 1.105E-2 2.780E-2
1.413E-1
9.944E-1
 1 16
35 SM00217 WAP SMART 1.105E-2 2.780E-2
1.413E-1
9.944E-1
 1 16
36 PS51390 WAP PROSITE 1.174E-2 2.780E-2
1.413E-1
1.000E0
 1 17
37 IPR009020 Propept inh InterPro 1.174E-2 2.780E-2
1.413E-1
1.000E0
 1 17
38 4.10.75.10 - Gene3D 1.174E-2 2.780E-2
1.413E-1
1.000E0
 1 17
39 SM00631 Zn pept SMART 1.242E-2 2.867E-2
1.457E-1
1.000E0
 1 18
40 PS00133 CARBOXYPEPT ZN 2 PROSITE 1.311E-2 2.887E-2
1.467E-1
1.000E0
 1 19
41 PS00132 CARBOXYPEPT ZN 1 PROSITE 1.379E-2 2.887E-2
1.467E-1
1.000E0
 1 20
42 IPR002477 Peptidoglycan-bd-like InterPro 1.379E-2 2.887E-2
1.467E-1
1.000E0
 1 20
43 PF01471 PG binding 1 Pfam 1.379E-2 2.887E-2
1.467E-1
1.000E0
 1 20
44 IPR008197 WAP dom InterPro 1.516E-2 2.971E-2
1.510E-1
1.000E0
 1 22
45 IPR000834 Peptidase M14 InterPro 1.585E-2 2.971E-2
1.510E-1
1.000E0
 1 23
46 PF00246 Peptidase M14 Pfam 1.585E-2 2.971E-2
1.510E-1
1.000E0
 1 23
47 IPR033739 M10A MMP InterPro 1.585E-2 2.971E-2
1.510E-1
1.000E0
 1 23
48 IPR021190 Pept M10A InterPro 1.585E-2 2.971E-2
1.510E-1
1.000E0
 1 23
49 PF00413 Peptidase M10 Pfam 1.653E-2 3.036E-2
1.543E-1
1.000E0
 1 24
50 PS50237 HECT PROSITE 1.858E-2 3.155E-2
1.604E-1
1.000E0
 1 27
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 100 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83075 Renin-angiotensin system BioSystems: KEGG 3.326E-14 3.326E-12 1.725E-11 3.326E-12 6 23
2 PW:0000492 renin-angiotensin system signaling Pathway Ontology 1.543E-12 7.717E-11 4.003E-10 1.543E-10 5 15
3 PW:0000529 angiotensin (1-7) signaling Pathway Ontology 3.571E-12 1.099E-10 5.702E-10 3.571E-10 4 5
4 1268749 Metabolism of Angiotensinogen to Angiotensins BioSystems: REACTOME 4.397E-12 1.099E-10 5.702E-10 4.397E-10 5 18
5 M12950 Angiotensin-converting enzyme 2 regulates heart function MSigDB C2 BIOCARTA (v6.0) 5.083E-10 1.017E-8 5.273E-8 5.083E-8 4 13
6 1268746 Peptide hormone metabolism BioSystems: REACTOME 2.295E-8 3.824E-7 1.984E-6 2.295E-6 5 91
7 PW:0000244 Angiotensin II signaling Pathway Ontology 1.063E-7 1.518E-6 7.876E-6 1.063E-5 3 10
8 PW:0000528 Angiotensin II signaling through the AT2 receptor Pathway Ontology 1.007E-6 1.007E-5 5.221E-5 1.007E-4 2 2
9 PW:0000245 angiotensin signaling Pathway Ontology 1.007E-6 1.007E-5 5.221E-5 1.007E-4 2 2
10 PW:0000531 Angiotensin III signaling through the AT2 receptor Pathway Ontology 1.007E-6 1.007E-5 5.221E-5 1.007E-4 2 2
11 PW:0000457 angiotensin III signaling Pathway Ontology 6.032E-6 5.484E-5 2.845E-4 6.032E-4 2 4
12 130626 Aldosterone-regulated sodium reabsorption BioSystems: KEGG 6.771E-6 5.642E-5 2.927E-4 6.771E-4 3 37
13 172847 Protein digestion and absorption BioSystems: KEGG 9.915E-5 7.627E-4 3.956E-3 9.915E-3 3 90
14 SMP00155 Rescinnamine Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
15 SMP00154 Ramipril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
16 SMP00146 Captopril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
17 SMP00157 Trandolapril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
18 SMP00153 Quinapril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
19 SMP00145 Benazepril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
20 SMP00147 Cilazapril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
21 SMP00156 Spirapril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
22 SMP00149 Fosinopril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
23 SMP00150 Lisinopril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
24 SMP00151 Moexipril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
25 SMP00152 Perindopril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
26 SMP00148 Enalapril Pathway SMPDB 5.541E-4 2.131E-3 1.106E-2
5.541E-2
 2 34
27 1269546 Peptide ligand-binding receptors BioSystems: REACTOME 8.668E-4 3.169E-3 1.644E-2
8.668E-2
 3 188
28 M13494 Bioactive Peptide Induced Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 8.872E-4 3.169E-3 1.644E-2
8.872E-2
 2 43
29 1269544 GPCR ligand binding BioSystems: REACTOME 9.676E-4 3.337E-3 1.731E-2
9.676E-2
 4 455
30 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 1.712E-3 5.707E-3 2.960E-2
1.712E-1
 3 238
31 1222951 Renin secretion BioSystems: KEGG 2.017E-3 6.507E-3 3.376E-2
2.017E-1
 2 65
32 PW:0000530 Angiotensin III signaling through the AT1 receptor Pathway Ontology 2.087E-3 6.523E-3 3.384E-2
2.087E-1
 1 2
33 PW:0000459 apelin signaling Pathway Ontology 3.130E-3 9.204E-3 4.775E-2
3.130E-1
 1 3
34 PW:0000527 Angiotensin II signaling through the AT1 receptor Pathway Ontology 3.130E-3 9.204E-3 4.775E-2
3.130E-1
 1 3
35 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 4.043E-3 1.127E-2
5.847E-2
4.043E-1
 3 322
36 PW:0000070 C21-Steroid hormone metabolic Pathway Ontology 4.171E-3 1.127E-2
5.847E-2
4.171E-1
 1 4
37 PW:0000458 angiotensin IV signaling Pathway Ontology 4.171E-3 1.127E-2
5.847E-2
4.171E-1
 1 4
38 413395 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone BioSystems: KEGG 6.250E-3 1.645E-2
8.532E-2
6.250E-1
 1 6
39 PW:0000540 obesity disease Pathway Ontology 8.325E-3 2.135E-2
1.107E-1
8.325E-1
 1 8
40 1270048 Glucocorticoid biosynthesis BioSystems: REACTOME 9.361E-3 2.283E-2
1.184E-1
9.361E-1
 1 9
41 PW:0000228 G protein signaling via Galphai family Pathway Ontology 9.361E-3 2.283E-2
1.184E-1
9.361E-1
 1 9
42 MAP00140 C21 Steroid hormone metabolism MAP00140 C21 Steroid hormone metabolism GenMAPP 1.040E-2 2.475E-2
1.284E-1
1.000E0
 1 10
43 PW:0000040 androgen and estrogen metabolic Pathway Ontology 1.143E-2 2.658E-2
1.379E-1
1.000E0
 1 11
44 M11736 Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. MSigDB C2 BIOCARTA (v6.0) 1.556E-2 3.536E-2
1.834E-1
1.000E0
 1 15
45 MAP00150 Androgen and estrogen metabolism MAP00150 Androgen and estrogen metabolism GenMAPP 1.761E-2 3.829E-2
1.986E-1
1.000E0
 1 17
46 138046 Syndecan-1-mediated signaling events BioSystems: Pathway Interaction Database 1.761E-2 3.829E-2
1.986E-1
1.000E0
 1 17
47 M7552 Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy MSigDB C2 BIOCARTA (v6.0) 1.864E-2 3.966E-2
2.058E-1
1.000E0
 1 18
48 137950 Signaling events mediated by the Hedgehog family BioSystems: Pathway Interaction Database 2.274E-2 4.738E-2
2.458E-1
1.000E0
 1 22
49 1269529 Downregulation of SMAD2/3:SMAD4 transcriptional activity BioSystems: REACTOME 2.376E-2 4.753E-2
2.465E-1
1.000E0
 1 23
50 137969 Signaling events mediated by PRL BioSystems: Pathway Interaction Database 2.376E-2 4.753E-2
2.465E-1
1.000E0
 1 23
Show 45 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 6509 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20486282 Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure. Pubmed 8.773E-16 5.710E-12 5.344E-11 5.710E-12 5 11
2 15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Pubmed 8.066E-15 2.625E-11 2.457E-10 5.250E-11 4 4
3 20592051 Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. Pubmed 1.209E-13 2.624E-10 2.456E-9 7.872E-10 4 6
4 11711524 Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. Pubmed 2.821E-13 4.591E-10 4.297E-9 1.836E-9 4 7
5 19716087 Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. Pubmed 5.642E-13 6.120E-10 5.728E-9 3.672E-9 4 8
6 25249154 The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Pubmed 5.642E-13 6.120E-10 5.728E-9 3.672E-9 4 8
7 11544438 Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
8 16133060 Implication of genetic variations in congenital obstructive nephropathy. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
9 18496132 Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
10 18205097 Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
11 11200871 Albuminuria and the renin-angiotensin system gene polymorphisms in type-2-diabetic and in normoglycemic hypertensive Chinese. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
12 11053482 Polymorphism of angiotensin converting enzyme, angiotensinogen, and angiotensin II type 1 receptor genes and end-stage renal failure in IgA nephropathy: IGARAS--a study of 274 Men. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
13 10969042 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Pubmed 3.080E-11 1.542E-8 1.443E-7 2.005E-7 3 3
14 12544508 A microarray minisequencing system for pharmacogenetic profiling of antihypertensive drug response. Pubmed 1.016E-10 3.084E-8 2.886E-7 6.615E-7 4 25
15 20606419 Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the Multi-ethnic Study of Atherosclerosis. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
16 19288324 Renin-angiotensin system polymorphisms: a risk factor for progression to end-stage renal disease in vesicoureteral reflux patients. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
17 12691672 The role of ACE2 in cardiovascular physiology. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
18 16001071 Angiotensin-converting enzyme 2 protects from severe acute lung failure. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
19 12579398 Renin-angiotensin system polymorphisms and renal scarring. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
20 17499413 Renin-angiotensin-system gene polymorphisms and depression. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
21 16006956 Low renin-angiotensin system activity gene polymorphism and dysplasia associated with posterior urethral valves. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
22 17522061 Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
23 9316207 Targeting the genes of angiotensin receptors. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
24 16954165 Genetic variation in the renin-angiotensin system and autonomic nervous system function in young healthy Japanese subjects. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
25 15013293 Angiotensin-converting enzyme genotype is a predictive factor in the peak panel-reactive antibody response. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
26 18328310 Genetic variation and activity of the renin-angiotensin system and severe hypoglycemia in type 1 diabetes. Pubmed 1.232E-10 3.084E-8 2.886E-7 8.018E-7 3 4
27 16609364 Restenosis after percutaneous coronary intervention is associated with the angiotensin-II type-1 receptor 1166A/C polymorphism but not with polymorphisms of angiotensin-converting enzyme, angiotensin-II receptor, angiotensinogen or heme oxygenase-1. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
28 19509012 Genetic variant of the Renin-Angiotensin system and diabetes influences blood pressure response to Angiotensin receptor blockers. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
29 15013333 Angiotensin-converting enzyme gene polymorphism significantly affects renal posttransplantation erythrocytosis. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
30 9973259 Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
31 20160196 Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
32 23636094 Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
33 17334527 Analysis of renin-angiotensin-aldosterone system gene polymorphisms in resistant hypertension. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
34 15385810 Association of the genetic polymorphisms of the renin-angiotensin system and endothelial nitric oxide synthase with chronic renal transplant dysfunction. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
35 15013322 The renin-angiotensin system and endothelial nitric oxide synthase gene polymorphisms and cyclosporine toxicity in renal transplant patients. Pubmed 3.079E-10 5.726E-8 5.359E-7 2.004E-6 3 5
36 17653210 Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population. Pubmed 6.157E-10 1.113E-7 1.042E-6 4.008E-6 3 6
37 15914614 Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. Pubmed 1.077E-9 1.895E-7 1.774E-6 7.012E-6 3 7
38 19082699 The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. Pubmed 5.075E-9 8.692E-7 8.134E-6 3.303E-5 3 11
39 18483625 A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. Pubmed 8.793E-9 1.431E-6 1.339E-5 5.723E-5 3 13
40 19155782 The environmental and genetic evidence for the association of hyperlipidemia and hypertension. Pubmed 8.793E-9 1.431E-6 1.339E-5 5.723E-5 3 13
41 15824464 The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Pubmed 1.721E-8 2.732E-6 2.556E-5 1.120E-4 3 16
42 21052031 Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Pubmed 2.975E-8 3.889E-6 3.639E-5 1.937E-4 3 19
43 18408592 Mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II expression in renal cell neoplasms: a tissue microarray and quantitative RT-PCR study. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
44 12426159 Relation of renin-angiotensin system gene polymorphisms and expressions with the efficacy of antihypertensive drugs. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
45 12830507 [The role of polymorphic variants of renin-angiotensin system genes in the development of ischemic stroke in Moscow population]. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
46 15112973 Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
47 17379330 AGT and ACE genes influence classic mitral valve prolapse predisposition in Marfan patients. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
48 16635753 Polymorphism of the renin-angiotensin-aldosterone system in patients with chronic allograft dysfunction. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
49 19948988 Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
50 20030467 Association of aldosterone concentration and mineralocorticoid receptor genotype with potassium response to spironolactone in patients with heart failure. Pubmed 1.069E-7 3.889E-6 3.639E-5 6.961E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 12 input genes in category / 442 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AGT AGT interactions 5.334E-12 2.358E-9 1.573E-8 2.358E-9 5 28
2 int:ACE ACE interactions 2.848E-8 6.294E-6 4.198E-5 1.259E-5 3 10
3 int:AGTR2 AGTR2 interactions 6.780E-8 9.989E-6 6.662E-5 2.997E-5 3 13
4 int:ACE2 ACE2 interactions 1.890E-5 2.088E-3 1.393E-2 8.353E-3 2 10
5 int:KLK3 KLK3 interactions 1.153E-4 1.019E-2
6.798E-2
5.096E-2
 2 24
6 int:PIK3CB PIK3CB interactions 4.867E-4 3.585E-2
2.391E-1
2.151E-1
 2 49
7 int:RANBP10 RANBP10 interactions 6.585E-4 4.158E-2
2.773E-1
2.910E-1
 2 57
8 int:PRLH PRLH interactions 1.355E-3 4.668E-2
3.114E-1
5.990E-1
 1 2
9 int:CYP26B1 CYP26B1 interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
10 int:KBTBD3 KBTBD3 interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
11 int:SLC7A7 SLC7A7 interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
12 int:SCN9A SCN9A interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
13 int:SLC22A8 SLC22A8 interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
14 int:FAM83F FAM83F interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
15 int:FAAH FAAH interactions 2.032E-3 4.668E-2
3.114E-1
8.983E-1
 1 3
16 int:MME MME interactions 2.468E-3 4.668E-2
3.114E-1
1.000E0
 2 111
17 int:EDN2 EDN2 interactions 2.709E-3 4.668E-2
3.114E-1
1.000E0
 1 4
18 int:SLC12A1 SLC12A1 interactions 2.709E-3 4.668E-2
3.114E-1
1.000E0
 1 4
19 int:MRVI1 MRVI1 interactions 2.709E-3 4.668E-2
3.114E-1
1.000E0
 1 4
20 int:SCN10A SCN10A interactions 2.709E-3 4.668E-2
3.114E-1
1.000E0
 1 4
21 int:SRMS SRMS interactions 2.709E-3 4.668E-2
3.114E-1
1.000E0
 1 4
22 int:ENPEP ENPEP interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
23 int:PRRG3 PRRG3 interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
24 int:ILDR1 ILDR1 interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
25 int:SCN1A SCN1A interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
26 int:DLEU2 DLEU2 interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
27 int:ARMC10 ARMC10 interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
28 int:PRRG1 PRRG1 interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
29 int:PRLHR PRLHR interactions 3.385E-3 4.668E-2
3.114E-1
1.000E0
 1 5
30 int:FOLH1 FOLH1 interactions 4.061E-3 4.668E-2
3.114E-1
1.000E0
 1 6
31 int:VDAC2 VDAC2 interactions 4.337E-3 4.668E-2
3.114E-1
1.000E0
 2 148
32 int:BRAF BRAF interactions 4.686E-3 4.668E-2
3.114E-1
1.000E0
 2 154
33 int:CLIC2 CLIC2 interactions 4.736E-3 4.668E-2
3.114E-1
1.000E0
 1 7
34 int:SLC22A11 SLC22A11 interactions 4.736E-3 4.668E-2
3.114E-1
1.000E0
 1 7
35 int:ADM ADM interactions 4.736E-3 4.668E-2
3.114E-1
1.000E0
 1 7
36 int:SCN3A SCN3A interactions 4.736E-3 4.668E-2
3.114E-1
1.000E0
 1 7
37 int:PKHD1 PKHD1 interactions 4.736E-3 4.668E-2
3.114E-1
1.000E0
 1 7
38 int:HSD11B2 HSD11B2 interactions 4.736E-3 4.668E-2
3.114E-1
1.000E0
 1 7
39 int:SCN8A SCN8A interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
40 int:DYRK3 DYRK3 interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
41 int:MAGEB1 MAGEB1 interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
42 int:WNK3 WNK3 interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
43 int:METTL7A METTL7A interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
44 int:SUSD6 SUSD6 interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
45 int:FAM234A FAM234A interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
46 int:SCN2A SCN2A interactions 5.411E-3 4.668E-2
3.114E-1
1.000E0
 1 8
47 int:ROBO3 ROBO3 interactions 6.086E-3 4.668E-2
3.114E-1
1.000E0
 1 9
48 int:RASL11B RASL11B interactions 6.086E-3 4.668E-2
3.114E-1
1.000E0
 1 9
49 int:KCNAB3 KCNAB3 interactions 6.086E-3 4.668E-2
3.114E-1
1.000E0
 1 9
50 int:PTHLH PTHLH interactions 6.086E-3 4.668E-2
3.114E-1
1.000E0
 1 9
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq22-q23 Xq22-q23 7.500E-4 4.875E-3 1.550E-2 9.750E-3 1 2
2 12p12.1-p11.2 12p12.1-p11.2 7.500E-4 4.875E-3 1.550E-2 9.750E-3 1 2
3 11q21-q22 11q21-q22 1.874E-3 8.121E-3 2.582E-2 2.436E-2 1 5
4 3q25.2 3q25.2 5.239E-3 1.250E-2 3.975E-2
6.811E-2
 1 14
5 4q31.1 4q31.1 5.985E-3 1.250E-2 3.975E-2
7.781E-2
 1 16
6 16q22 16q22 6.731E-3 1.250E-2 3.975E-2
8.751E-2
 1 18
7 18q21 18q21 6.731E-3 1.250E-2 3.975E-2
8.751E-2
 1 18
8 1q42.2 1q42.2 9.338E-3 1.311E-2 4.168E-2
1.214E-1
 1 25
9 20q12 20q12 9.709E-3 1.311E-2 4.168E-2
1.262E-1
 1 26
10 Xp22 Xp22 1.008E-2 1.311E-2 4.168E-2
1.311E-1
 1 27
11 17q23.3 17q23.3 1.120E-2 1.323E-2 4.208E-2
1.455E-1
 1 30
12 3q24 3q24 1.231E-2 1.333E-2 4.241E-2
1.600E-1
 1 33
13 2q37.3 2q37.3 3.215E-2 3.215E-2
1.022E-1
4.179E-1
 1 87
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 117 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 12 input genes in category / 11 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 542 Endogenous ligands genenames.org 4.402E-4 4.842E-3 1.462E-2 4.842E-3 3 237
2 221 X-linked mental retardation|Angiotensin receptors genenames.org 1.319E-3 7.253E-3 2.190E-2 1.451E-2 1 2
3 361 WAP four-disulfide core domain containing genenames.org 1.181E-2 3.458E-2
1.044E-1
1.299E-1
 1 18
4 1321 Carboxypeptidases genenames.org 1.377E-2 3.458E-2
1.044E-1
1.514E-1
 1 21
5 891 Matrix metallopeptidases genenames.org 1.572E-2 3.458E-2
1.044E-1
1.729E-1
 1 24
6 823 C2 domain containing|Calpains genenames.org 2.349E-2 3.678E-2
1.111E-1
2.584E-1
 1 36
7 739 Serpin peptidase inhibitors genenames.org 2.414E-2 3.678E-2
1.111E-1
2.655E-1
 1 37
8 471 CD molecules|Tumor necrosis factor superfamily genenames.org 2.675E-2 3.678E-2
1.111E-1
2.942E-1
 2 394
9 71 Nuclear hormone receptors genenames.org 3.185E-2 3.893E-2
1.176E-1
3.504E-1
 1 49
Show 4 more annotations

13: Coexpression [Display Chart] 13 input genes in category / 1446 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15476 Genes up-regulated in primary adipocytes compared to preadipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.778E-6 1.269E-2
9.969E-2
 1.269E-2 3 74
2 11375906-table1 Rat Prostate Ouyang01 17genes GeneSigDB 3.047E-5 2.203E-2
1.730E-1
 4.407E-2 2 15
3 14555994-Table3 Human Kidney Takahashi03 30genes chromophobe GeneSigDB 8.679E-5 2.743E-2
2.154E-1
1.255E-1
 2 25
4 15901920-Table6 Rat Testicular Naciff05 48genes GeneSigDB 1.524E-4 2.743E-2
2.154E-1
2.203E-1
 2 33
5 M2737 Genes down-regulated in TIG3 cells (fibroblasts) upon knockdown of EZH2 [Gene ID=2146] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.537E-4 2.743E-2
2.154E-1
2.222E-1
 3 193
6 M6141 Genes up-regulated in CD8 alphabeta OT1 thymocyte RTOC culture versus CD8 alphaalpha HY thymocyte RTOC culture. MSigDB C7: Immunologic Signatures (v6.0) 1.584E-4 2.743E-2
2.154E-1
2.291E-1
 3 195
7 M8098 Genes up-regulated in speen B lymphocytes: marginal zone versus follicular. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.743E-2
2.154E-1
2.469E-1
 3 200
8 M9624 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: control versus NaCl treatment. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.743E-2
2.154E-1
2.469E-1
 3 200
9 M5144 Genes down-regulated in untreated dendritic cells (DC) versus DCs exposed to parasite L. donovani. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 2.743E-2
2.154E-1
2.469E-1
 3 200
10 11983058-Table2 Human Leukemia Bo02 50genes ColonTumor/NormalClassSeparation GeneSigDB 2.246E-4 2.966E-2
2.329E-1
3.248E-1
 2 40
11 M1591 Cluster 5: genes progressively up-regulated (peak at 24 h time point) during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.598E-4 2.966E-2
2.329E-1
3.756E-1
 2 43
12 18803589-Table1 Human Viral Pazienza08 52genes GeneSigDB 2.720E-4 2.966E-2
2.329E-1
3.934E-1
 2 44
13 16232197-Table2 Human Lung Peng05 62genes GeneSigDB 2.720E-4 2.966E-2
2.329E-1
3.934E-1
 2 44
14 M8570 Genes down-regulated in breast cancer samples positive for ESR1 [GeneID=2099] compared to the ESR1 negative tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.240E-4 2.966E-2
2.329E-1
4.685E-1
 2 48
15 16491124-SuppTable2 Human Breast Doane06 57genes GeneSigDB 3.240E-4 2.966E-2
2.329E-1
4.685E-1
 2 48
16 M11695 Genes up-regulated by estradiol (E2) [PubChem=5757] in U2OS cells (osteosarcoma) expressing ESR1 or ESR2 [GeneID=2099;2100]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.516E-4 2.966E-2
2.329E-1
5.084E-1
 2 50
17 M1286 Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.946E-4 2.966E-2
2.329E-1
5.706E-1
 3 266
18 17409405-Table1a Human Breast Huper07 66genes BasalCells GeneSigDB 3.951E-4 2.966E-2
2.329E-1
5.714E-1
 2 53
19 M13422 Genes up-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.102E-4 2.966E-2
2.329E-1
5.932E-1
 2 54
20 16455954-Table2 Human StemCell Dekker06 107genes GeneSigDB 4.102E-4 2.966E-2
2.329E-1
5.932E-1
 2 54
21 M2316 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of both BMI1 and PCGF2 [GeneID=648, 7703] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.571E-4 3.111E-2
2.443E-1
6.609E-1
 2 57
22 12730682-Table1 Human Breast Mackay03 61genes GeneSigDB 4.733E-4 3.111E-2
2.443E-1
6.843E-1
 2 58
23 M2456 Genes requiring MLL [GeneID=4297] for H3K4me3 and expression in MEF cells (embryonic fibroblast). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.027E-4 3.161E-2
2.482E-1
7.269E-1
 3 289
24 M1322 Genes down-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.761E-4 3.471E-2
2.726E-1
8.330E-1
 2 64
25 M16774 Genes down-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.126E-4 3.543E-2
2.783E-1
8.858E-1
 2 66
26 M2700 Genes down-regulated in bone relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.401E-4 3.559E-2
2.795E-1
9.256E-1
 3 314
27 M1406 Genes up-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.085E-4 3.559E-2
2.795E-1
1.000E0
 2 71
28 20096135-Table2 Human Liver Utispan10 75genes GeneSigDB 7.085E-4 3.559E-2
2.795E-1
1.000E0
 2 71
29 M4008 Genes which best discriminate between two groups of breast cancer according to the status of ESR1 and AR [GeneID=2099;367]: apocrine (ESR1- AR+) and luminal (ESR1+ AR+). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.138E-4 3.559E-2
2.795E-1
1.000E0
 3 326
30 M6939 Survival signature genes defined in adjacent liver tissue: genes correlated with poor survival of hepatocellular carcinoma (HCC) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.488E-4 3.589E-2
2.819E-1
1.000E0
 2 73
31 15273739-Table1 Human Intestine Jinawath04 75genes UpRegulated GeneSigDB 7.694E-4 3.589E-2
2.819E-1
1.000E0
 2 74
32 12782598-Table1 Human Ovarian Schwartz03 81genes GeneSigDB 8.113E-4 3.666E-2
2.879E-1
1.000E0
 2 76
33 19395651-TableS1a Mouse StemCell Bonuccelli09 119genes GeneSigDB 8.984E-4 3.813E-2
2.995E-1
1.000E0
 2 80
34 M1720 Top 100 ranked genes most specific to midbrain region of adult mouse brain. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.436E-4 3.813E-2
2.995E-1
1.000E0
 2 82
35 15788672-Table1 Human Prostate Gu05 120genes GeneSigDB 9.436E-4 3.813E-2
2.995E-1
1.000E0
 2 82
36 M7517 Genes up-regulated in the luminal A subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.899E-4 3.813E-2
2.995E-1
1.000E0
 2 84
37 20032505-TableS3 Human Leukemia Stam09 97genes GeneSigDB 9.899E-4 3.813E-2
2.995E-1
1.000E0
 2 84
38 16509772-TableS1 Human StemCell Coller06 136genes GeneSigDB 1.086E-3 3.813E-2
2.995E-1
1.000E0
 2 88
39 M2109 Genes whose expression significantly and negatively correlated with oligodendrocyte density in layer VI of BA9 brain region in patients with bipolar disorder. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.086E-3 3.813E-2
2.995E-1
1.000E0
 2 88
40 17148579-TableS1 Human Leukemia Bomben07 122genes GeneSigDB 1.110E-3 3.813E-2
2.995E-1
1.000E0
 2 89
41 M215 Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.110E-3 3.813E-2
2.995E-1
1.000E0
 2 89
42 M2154 Genes down-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.160E-3 3.813E-2
2.995E-1
1.000E0
 2 91
43 16857994-TableS1 Human Leukemia Chapiro06 156genes GeneSigDB 1.160E-3 3.813E-2
2.995E-1
1.000E0
 2 91
44 M3672 Genes down-regulated in lobular carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.160E-3 3.813E-2
2.995E-1
1.000E0
 2 91
45 15846300-SuppTable3 Human Stomach Hofsli05 99genes RegulatedbyEGF GeneSigDB 1.290E-3 4.145E-2
3.255E-1
1.000E0
 2 96
46 16618722-Table1 Human InVitro Glesne06 108genes GeneSigDB 1.371E-3 4.309E-2
3.385E-1
1.000E0
 2 99
47 15885264-Table1 Mouse Lung not cancer Lee05 127genes GeneSigDB 1.599E-3 4.877E-2
3.831E-1
1.000E0
 2 107
48 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 1.619E-3 4.877E-2
3.831E-1
1.000E0
 3 433
49 15793299-TableB Mouse Breast Astolfi05 31genes GeneSigDB 1.685E-3 4.900E-2
3.849E-1
1.000E0
 1 3
50 M431 Genes down-regulated in mature inhibitory dendritic cells: L. monocytogenes infection versus prostaglandin E2 [PubChem=5280360]. MSigDB C7: Immunologic Signatures (v6.0) 1.719E-3 4.900E-2
3.849E-1
1.000E0
 2 111
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 1524 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/4/0 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/4/0 TCGA-Pancreas 7.741E-7 1.180E-3 9.328E-3 1.180E-3 4 128
2 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/4/1 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/4/1 TCGA-Stomach 2.348E-6 1.789E-3 1.414E-2 3.578E-3 4 169
3 gudmap developingLowerUrinaryTract P1 ureter 500 k3 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.370E-5 6.962E-3
5.505E-2
 2.089E-2 3 81
4 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/1/3 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/1/3 TCGA-Pancreas 3.526E-5 9.645E-3
7.626E-2
5.374E-2
 3 111
5 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma/Malignant Peripheral Nerve Sheath Tumors /0 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma/Malignant Peripheral Nerve Sheath Tumors /0 TCGA-Bone and Soft Tissue 3.622E-5 9.645E-3
7.626E-2
5.520E-2
 3 112
6 gudmap RNAseq e15.5 Mesangium 2500 K1 gudmap RNAseq e15.5 Mesangium 2500 K1 Gudmap RNAseq 4.233E-5 9.645E-3
7.626E-2
6.451E-2
 3 118
7 gudmap dev gonad e11.5 M GonadVasMes Flk k2 100 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 4.430E-5 9.645E-3
7.626E-2
6.752E-2
 2 17
8 gudmap developingKidney e15.5 Peripheral blastema 500 k5 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.832E-5 1.266E-2
1.001E-1
1.041E-1
 2 21
9 gudmap dev gonad e12.5 F VasAssMesen MafB k4 500 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.144E-5 1.266E-2
1.001E-1
1.241E-1
 3 147
10 gallbladder gallbladder Human Protein Atlas 8.310E-5 1.266E-2
1.001E-1
1.266E-1
 3 148
11 gudmap developingKidney e15.5 Peripheral blastema 1000 k4 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.746E-5 1.296E-2
1.024E-1
1.485E-1
 2 25
12 gudmap dev gonad e11.5 F GonadVasMes Flk 200 dev gonad e11.5 F GonadVasMes Flk top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.067E-4 1.296E-2
1.024E-1
1.626E-1
 3 161
13 gudmap dev gonad e12.5 M InterstitLeydig MafB k2 500 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.147E-4 1.296E-2
1.024E-1
1.748E-1
 3 165
14 gudmap kidney e15.5 Podocyte MafB 200 kidney e15.5 Podocyte MafB top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.231E-4 1.296E-2
1.024E-1
1.877E-1
 3 169
15 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/4/1 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/4/1 TCGA-Uterus 1.275E-4 1.296E-2
1.024E-1
1.943E-1
 3 171
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal Wilms R U/Kidney Normal Wilms R14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal Wilms R U/Kidney Normal Wilms R14 Adult, Development, and Cancer types 1.365E-4 1.301E-2
1.028E-1
2.081E-1
 3 175
17 Collecting duct (CD) Collecting duct (CD) 1.795E-4 1.520E-2
1.202E-1
2.736E-1
 3 192
18 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Collecting duct (CD) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Collecting duct (CD) Fetal, Development 1.795E-4 1.520E-2
1.202E-1
2.736E-1
 3 192
19 gudmap dev gonad e11.5 F GonadVasMes Flk k1 200 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.155E-4 1.729E-2
1.367E-1
3.284E-1
 2 37
20 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.273E-4 1.732E-2
1.369E-1
3.464E-1
 3 208
21 gudmap dev gonad e12.5 F VasAssMesen MafB k2 200 dev gonad e12.5 F VasAssMesen MafB k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.781E-4 2.018E-2
1.596E-1
4.239E-1
 2 42
22 gudmap developingGonad e12.5 epididymis k4 500 DevelopingGonad e12.5 epididymis emap-29139 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.339E-4 2.313E-2
1.829E-1
5.088E-1
 2 46
23 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 1000 K1 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 4.623E-4 2.968E-2
2.347E-1
7.046E-1
 3 265
24 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 4.674E-4 2.968E-2
2.347E-1
7.124E-1
 3 266
25 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C9-KC4 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C9-KC4 Top 200 Genes 5.151E-4 3.102E-2
2.453E-1
7.850E-1
 3 275
26 gudmap dev gonad e11.5 F GonMes Sma k4 500 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.311E-4 3.102E-2
2.453E-1
8.094E-1
 2 58
27 gudmap dev gonad e12.5 M InterstitLeydig MafB k2 200 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.496E-4 3.102E-2
2.453E-1
8.375E-1
 2 59
28 gudmap developingLowerUrinaryTract adult ureter 1000 k2 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.716E-4 3.111E-2
2.460E-1
8.711E-1
 3 285
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Private/Kidney NephrogenicRest Wilms Private/Kidney NephrogenicRest Wilms IN5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Private/Kidney NephrogenicRest Wilms Private/Kidney NephrogenicRest Wilms IN5 Adult, Development, and Cancer types 5.955E-4 3.130E-2
2.475E-1
9.076E-1
 1 1
30 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C10-KC4 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C10-KC4 Top 200 Genes 7.029E-4 3.571E-2
2.823E-1
1.000E0
 3 306
31 gudmap dev gonad e12.5 M InterstitLeydig MafB k1 1000 dev gonad e12.5 M InterstitLeydig MafB k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 7.368E-4 3.600E-2
2.847E-1
1.000E0
 3 311
32 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT2 PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT2 PND07-28 Top 200 Genes 8.003E-4 3.600E-2
2.847E-1
1.000E0
 3 320
33 duodenum duodenum Human Protein Atlas 8.076E-4 3.600E-2
2.847E-1
1.000E0
 3 321
34 kidney kidney Human Protein Atlas 8.223E-4 3.600E-2
2.847E-1
1.000E0
 3 323
35 Facebase RNAseq e8.5 Paraxial Mesoderm 1000 K2 FacebaseRNAseq e8.5 Paraxial Mesoderm top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 8.827E-4 3.600E-2
2.847E-1
1.000E0
 3 331
36 gudmap dev gonad e11.5 M GonadVasMes Flk k3 200 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.102E-4 3.600E-2
2.847E-1
1.000E0
 2 76
37 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.218E-4 3.600E-2
2.847E-1
1.000E0
 3 336
38 BM Top 100 - trigeminal ganglia BM Top 100 - trigeminal ganglia Body Map 9.341E-4 3.600E-2
2.847E-1
1.000E0
 2 77
39 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.378E-4 3.600E-2
2.847E-1
1.000E0
 3 338
40 small intestine small intestine Human Protein Atlas 9.458E-4 3.600E-2
2.847E-1
1.000E0
 3 339
41 gudmap dev gonad e13.5 M InterstitFLeydig MafB k3 200 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.058E-3 3.600E-2
2.847E-1
1.000E0
 2 82
42 gudmap dev gonad e11.5 M GonadVasMes Flk 100 dev gonad e11.5 M GonadVasMes Flk top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 1.058E-3 3.600E-2
2.847E-1
1.000E0
 2 82
43 gudmap kidney e15.5 Podocyte MafB 100 kidney e15.5 Podocyte MafB top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.058E-3 3.600E-2
2.847E-1
1.000E0
 2 82
44 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.081E-3 3.600E-2
2.847E-1
1.000E0
 3 355
45 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal Fetal, Development 1.084E-3 3.600E-2
2.847E-1
1.000E0
 2 83
46 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB 500 dev gonad e13.5 F VascAssocMesenchStromOvary MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.107E-3 3.600E-2
2.847E-1
1.000E0
 3 358
47 BM Top 100 - kidney cortex BM Top 100 - kidney cortex Body Map 1.110E-3 3.600E-2
2.847E-1
1.000E0
 2 84
48 gudmap dev gonad e12.5 M InterstitLeydig MafB 500 dev gonad e12.5 M InterstitLeydig MafB top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.162E-3 3.688E-2
2.916E-1
1.000E0
 3 364
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour VHL RCC Mast cell/Kidney Tumour VHL RCC IT21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour VHL RCC Mast cell/Kidney Tumour VHL RCC IT21 Adult, Development, and Cancer types 1.191E-3 3.703E-2
2.928E-1
1.000E0
 1 2
50 facebase RNAseq e14.5 palate poster proximal ERK2 WT 2500 K0 facebase RNAseq e14.5 palate poster proximal ERK2 WT 2500 K0 Gudmap RNAseq 1.218E-3 3.711E-2
2.934E-1
1.000E0
 2 88
Show 45 more annotations

15: Computational [Display Chart] 12 input genes in category / 97 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17376 MODULE 107 Genes in the cancer module 107. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.811E-5 5.666E-3 2.922E-2 9.517E-3 3 79
2 M15716 MODULE 209 Catabolic peptidases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.399E-4 5.666E-3 2.922E-2 1.357E-2 3 89
3 M10041 MODULE 172 Genes in the cancer module 172. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.752E-4 5.666E-3 2.922E-2 1.700E-2 3 96
4 M13268 MODULE 210 Genes in the cancer module 210. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.869E-4 1.181E-2
6.089E-2
 4.722E-2 2 28
5 M19173 MODULE 280 Metal ion (zinc) binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.261E-3 2.446E-2
1.261E-1
1.223E-1
 2 45
6 M6257 MODULE 164 Enzyme inhibitors (esp serine proteases). MSigDb: C4 - CM: Cancer Modules (v6.0) 2.306E-3 3.728E-2
1.922E-1
2.237E-1
 2 61
Show 1 more annotation

16: MicroRNA [Display Chart] 13 input genes in category / 251 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 4.728E-5 1.187E-2
7.244E-2
 1.187E-2 3 403
2 hsa-miR-1267:PITA hsa-miR-1267:PITA TOP PITA 3.379E-4 3.246E-2
1.981E-1
8.480E-2
 2 152
3 hsa-miR-575:PITA hsa-miR-575:PITA TOP PITA 5.156E-4 3.246E-2
1.981E-1
1.294E-1
 2 188
4 TTTGCAG,MIR-518A-2:MSigDB TTTGCAG,MIR-518A-2:MSigDB MSigDB 5.658E-4 3.246E-2
1.981E-1
1.420E-1
 2 197
5 hsa-miR-369-5p:mirSVR lowEffct hsa-miR-369-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.792E-4 3.246E-2
1.981E-1
1.705E-1
 2 216
6 hsa-miR-409-3p:TargetScan hsa-miR-409-3p TargetScan 7.759E-4 3.246E-2
1.981E-1
1.947E-1
 2 231
7 hsa-miR-302f:PITA hsa-miR-302f:PITA TOP PITA 1.080E-3 3.872E-2
2.364E-1
2.710E-1
 2 273
8 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 1.405E-3 4.409E-2
2.692E-1
3.527E-1
 2 312
9 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 2.688E-3 4.449E-2
2.716E-1
6.748E-1
 2 434
10 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 2.688E-3 4.449E-2
2.716E-1
6.748E-1
 2 434
11 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 2.688E-3 4.449E-2
2.716E-1
6.748E-1
 2 434
12 hsa-miR-4304:mirSVR lowEffct hsa-miR-4304:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.247E-3 4.449E-2
2.716E-1
8.150E-1
 2 478
13 hsa-miR-4253:mirSVR highEffct hsa-miR-4253:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.247E-3 4.449E-2
2.716E-1
8.150E-1
 2 478
14 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 3.274E-3 4.449E-2
2.716E-1
8.217E-1
 2 480
15 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 3.354E-3 4.449E-2
2.716E-1
8.419E-1
 2 486
16 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 3.368E-3 4.449E-2
2.716E-1
8.453E-1
 2 487
17 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 3.368E-3 4.449E-2
2.716E-1
8.453E-1
 2 487
18 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 3.368E-3 4.449E-2
2.716E-1
8.453E-1
 2 487
19 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 3.368E-3 4.449E-2
2.716E-1
8.453E-1
 2 487
Show 14 more annotations

17: Drug [Display Chart] 13 input genes in category / 5127 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D001623 Betamethasone CTD 4.111E-15 2.108E-11 1.922E-10 2.108E-11 6 29
2 CID000005839 aldosterone Stitch 8.897E-14 2.281E-10 2.080E-9 4.561E-10 9 397
3 CID000177236 darusentan Stitch 3.476E-13 5.941E-10 5.418E-9 1.782E-9 6 58
4 CID003083715 angiotensin Stitch 5.965E-13 7.645E-10 6.972E-9 3.058E-9 8 282
5 ctd:C081643 candesartan CTD 1.584E-12 1.615E-9 1.473E-8 8.123E-9 6 74
6 CID000152660 Arg-pro-pro Stitch 1.994E-12 1.615E-9 1.473E-8 1.022E-8 5 27
7 CID000060919 tasosartan Stitch 2.205E-12 1.615E-9 1.473E-8 1.131E-8 4 7
8 CID000004350 Z-PP-CHO Stitch 3.516E-12 2.253E-9 2.055E-8 1.803E-8 5 30
9 CID000132387 Abbott-81988 Stitch 4.409E-12 2.260E-9 2.061E-8 2.260E-8 4 8
10 CID003085266 Neurotensin (1-10) Stitch 4.409E-12 2.260E-9 2.061E-8 2.260E-8 4 8
11 CID000410009 AC1L8Y60 Stitch 4.950E-12 2.307E-9 2.104E-8 2.538E-8 6 89
12 CID011979316 vasopressin Stitch 7.712E-12 2.905E-9 2.650E-8 3.954E-8 8 388
13 CID000447320 angiotensin I Stitch 7.933E-12 2.905E-9 2.650E-8 4.067E-8 4 9
14 CID000133986 MDL 100,173 Stitch 7.933E-12 2.905E-9 2.650E-8 4.067E-8 4 9
15 CID000005525 CI-907 Stitch 1.073E-11 3.668E-9 3.345E-8 5.503E-8 5 37
16 ctd:D013148 Spironolactone CTD 1.365E-11 4.374E-9 3.989E-8 6.999E-8 6 105
17 CID000133985 MDL 100240 Stitch 2.076E-11 5.644E-9 5.147E-8 1.065E-7 4 11
18 CID000132708 Rb 104 Stitch 2.076E-11 5.644E-9 5.147E-8 1.065E-7 4 11
19 CID000003419 Secorvas Stitch 2.091E-11 5.644E-9 5.147E-8 1.072E-7 5 42
20 CID000132562 D 8731 Stitch 3.114E-11 7.256E-9 6.618E-8 1.596E-7 4 12
21 CID005487537 Rb 105 Stitch 3.114E-11 7.256E-9 6.618E-8 1.596E-7 4 12
22 CID000131850 alatriopril Stitch 3.114E-11 7.256E-9 6.618E-8 1.596E-7 4 12
23 CID000150310 Selara Stitch 3.958E-11 8.233E-9 7.508E-8 2.029E-7 6 125
24 CID000003222 CAS 76095-16-4 Stitch 4.155E-11 8.233E-9 7.508E-8 2.130E-7 6 126
25 CID003691183 AC1MVZ0B Stitch 4.202E-11 8.233E-9 7.508E-8 2.155E-7 5 48
26 CID000132706 SC-52458 Stitch 4.496E-11 8.233E-9 7.508E-8 2.305E-7 4 13
27 CID000171857 YS980 Stitch 4.496E-11 8.233E-9 7.508E-8 2.305E-7 4 13
28 CID006324648 sampatrilat Stitch 4.496E-11 8.233E-9 7.508E-8 2.305E-7 4 13
29 CID005493444 aliskiren Stitch 5.197E-11 9.188E-9 8.379E-8 2.664E-7 5 50
30 CID000123805 angiotensin (1-7) Stitch 5.760E-11 9.844E-9 8.977E-8 2.953E-7 5 51
31 CID000131965 SCH 42495 Stitch 6.293E-11 1.008E-8 9.194E-8 3.226E-7 4 14
32 CID000062956 fosinoprilat Stitch 6.293E-11 1.008E-8 9.194E-8 3.226E-7 4 14
33 CID000005038 CAS 87333-19-5 Stitch 7.033E-11 1.093E-8 9.964E-8 3.606E-7 5 53
34 CID000003001 NSC9567 Stitch 8.233E-11 1.242E-8 1.132E-7 4.221E-7 6 141
35 CID005464096 ramiprilat Stitch 8.520E-11 1.248E-8 1.138E-7 4.368E-7 5 55
36 CID003640214 AC1MUFT5 Stitch 1.143E-10 1.462E-8 1.333E-7 5.862E-7 4 16
37 CID006450805 aladotrilat Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
38 CID006450804 aladotril Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
39 CID000083478 GaI3 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
40 CID000127983 Rev 5975 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
41 CID000089016 tert-butyl L-alaninate Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
42 CID000134126 CGS 13934 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
43 CID005311337 BP1.137 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
44 CID000181457 C112 Peptide Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
45 CID003084602 AC1MJ2VJ Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
46 CID000181456 C111 Peptide Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
47 CID005489408 MDL 27,088 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
48 CID005488868 MC-838 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
49 CID003080984 Wf 10129 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
50 CID000124628 L-681,176 Stitch 1.440E-10 1.462E-8 1.333E-7 7.384E-7 3 3
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 1084 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0565599 Maternal hypertension DisGeNET Curated 1.773E-10 1.922E-7 1.454E-6 1.922E-7 4 13
2 C0085580 Essential Hypertension DisGeNET Curated 7.398E-10 4.010E-7 3.034E-6 8.020E-7 7 284
3 C0598428 genetic hypertension DisGeNET BeFree 6.744E-9 2.437E-6 1.844E-5 7.310E-6 4 30
4 C0268790 Renal vascular disorder DisGeNET BeFree 1.409E-8 3.137E-6 2.373E-5 1.527E-5 3 7
5 C1565489 Renal Insufficiency DisGeNET Curated 1.447E-8 3.137E-6 2.373E-5 1.568E-5 6 237
6 C0238506 Congenital posterior urethral valves DisGeNET Curated 2.253E-8 4.071E-6 3.080E-5 2.443E-5 3 8
7 C0597048 Neurogenic hypertension DisGeNET BeFree 3.378E-8 5.232E-6 3.958E-5 3.662E-5 3 9
8 C0020544 Renal hypertension DisGeNET Curated 1.148E-7 1.556E-5 1.177E-4 1.245E-4 3 13
9 C0042580 Vesico-Ureteral Reflux DisGeNET Curated 1.640E-7 1.976E-5 1.495E-4 1.778E-4 4 65
10 C0149721 Left Ventricular Hypertrophy DisGeNET Curated 1.863E-7 2.019E-5 1.528E-4 2.019E-4 5 179
11 C0013537 Eclampsia DisGeNET Curated 2.641E-7 2.110E-5 1.596E-4 2.863E-4 5 192
12 C0152105 Hypertensive heart disease DisGeNET BeFree 2.725E-7 2.110E-5 1.596E-4 2.954E-4 3 17
13 C0221043 Liddle Syndrome DisGeNET Curated 2.725E-7 2.110E-5 1.596E-4 2.954E-4 3 17
14 C3854315 Pseudoprimary hyperaldosteronism DisGeNET BeFree 2.725E-7 2.110E-5 1.596E-4 2.954E-4 3 17
15 C0020488 Hypernatremia DisGeNET Curated 3.268E-7 2.362E-5 1.787E-4 3.543E-4 3 18
16 C0017667 Nodular glomerulosclerosis DisGeNET BeFree 3.879E-7 2.628E-5 1.989E-4 4.205E-4 3 19
17 C0032962 Pregnancy Complications DisGeNET Curated 6.122E-7 3.904E-5 2.953E-4 6.636E-4 4 90
18 C0004238 Atrial Fibrillation DisGeNET Curated 6.752E-7 4.066E-5 3.077E-4 7.319E-4 5 232
19 C0003507 Aortic Valve Stenosis DisGeNET Curated 1.274E-6 7.267E-5 5.498E-4 1.381E-3 4 108
20 C0745136 Hypertensive emergency DisGeNET BeFree 1.781E-6 9.656E-5 7.305E-4 1.931E-3 2 3
21 C4020969 Inflammatory abnormality of the eye DisGeNET Curated 2.379E-6 1.200E-4 9.080E-4 2.579E-3 3 34
22 C3887486 Interstitial lung fibrosis DisGeNET BeFree 2.435E-6 1.200E-4 9.080E-4 2.640E-3 4 127
23 C0007192 Cardiomyopathy, Alcoholic DisGeNET Curated 3.561E-6 1.430E-4 1.082E-3 3.860E-3 2 4
24 cv:C0266313 Renal dysplasia Clinical Variations 3.561E-6 1.430E-4 1.082E-3 3.860E-3 2 4
25 OMIN:267430 RENAL TUBULAR DYSGENESIS; RTD OMIM 3.561E-6 1.430E-4 1.082E-3 3.860E-3 2 4
26 C0400979 Obstruction of biliary tree DisGeNET BeFree 3.561E-6 1.430E-4 1.082E-3 3.860E-3 2 4
27 C0266313 Allanson Pantzar McLeod syndrome DisGeNET Curated 3.561E-6 1.430E-4 1.082E-3 3.860E-3 2 4
28 C3272363 Ischemic Cerebrovascular Accident DisGeNET BeFree 4.425E-6 1.675E-4 1.267E-3 4.796E-3 5 340
29 C0002940 Aneurysm DisGeNET Curated 4.480E-6 1.675E-4 1.267E-3 4.857E-3 4 148
30 C0342488 Mineralocorticoid Excess Syndrome, Apparent DisGeNET Curated 5.933E-6 2.099E-4 1.588E-3 6.431E-3 2 5
31 C0020428 Hyperaldosteronism DisGeNET Curated 6.002E-6 2.099E-4 1.588E-3 6.506E-3 3 46
32 C0948008 Ischemic stroke DisGeNET Curated 6.511E-6 2.139E-4 1.618E-3 7.057E-3 5 368
33 C0042373 Vascular Diseases DisGeNET Curated 6.511E-6 2.139E-4 1.618E-3 7.057E-3 5 368
34 C4049883 Obstructive Ureterocele DisGeNET BeFree 6.832E-6 2.178E-4 1.648E-3 7.406E-3 3 48
35 C0268731 Renal glomerular disease DisGeNET Curated 7.764E-6 2.405E-4 1.819E-3 8.416E-3 4 170
36 C0010481 Cushing Syndrome DisGeNET Curated 8.713E-6 2.624E-4 1.985E-3 9.445E-3 3 52
37 C0026267 Mitral Valve Prolapse Syndrome DisGeNET Curated 9.232E-6 2.705E-4 2.046E-3 1.001E-2 3 53
38 C2076596 Influenza A/H5N1 DisGeNET BeFree 1.245E-5 3.551E-4 2.687E-3 1.349E-2 2 7
39 C0002965 Angina, Unstable DisGeNET Curated 1.344E-5 3.736E-4 2.827E-3 1.457E-2 3 60
40 C0038443 Stress, Psychological DisGeNET BeFree 1.413E-5 3.736E-4 2.827E-3 1.532E-2 3 61
41 C0013295 Duodenal Ulcer DisGeNET Curated 1.413E-5 3.736E-4 2.827E-3 1.532E-2 3 61
42 C0239946 Fibrosis, Liver DisGeNET Curated 1.451E-5 3.742E-4 2.831E-3 1.573E-2 5 434
43 C0751674 Lymphangioleiomyomatosis DisGeNET Curated 1.484E-5 3.742E-4 2.831E-3 1.609E-2 3 62
44 C0036202 Sarcoidosis DisGeNET Curated 1.626E-5 3.826E-4 2.895E-3 1.763E-2 4 205
45 C0085612 Ventricular arrhythmia DisGeNET Curated 1.634E-5 3.826E-4 2.895E-3 1.771E-2 3 64
46 C0003460 Anuria DisGeNET Curated 1.659E-5 3.826E-4 2.895E-3 1.798E-2 2 8
47 C0741949 Cardiovascular Pathology DisGeNET BeFree 1.659E-5 3.826E-4 2.895E-3 1.798E-2 2 8
48 C0010200 Coughing DisGeNET Curated 1.961E-5 4.429E-4 3.351E-3 2.126E-2 3 68
49 C0264716 Chronic heart failure DisGeNET BeFree 2.050E-5 4.444E-4 3.363E-3 2.222E-2 3 69
50 C0264641 Endocrine hypertension DisGeNET BeFree 2.132E-5 4.444E-4 3.363E-3 2.311E-2 2 9
Show 45 more annotations