Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc108_15, positive side

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1: GO: Molecular Function [Display Chart] 15 input genes in category / 66 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035091 phosphatidylinositol binding 1.551E-14 1.024E-12 4.888E-12 1.024E-12 9 217
2 GO:0005543 phospholipid binding 2.769E-12 9.139E-11 4.363E-10 1.828E-10 9 385
3 GO:1990460 leptin receptor binding 4.202E-10 9.244E-9 4.413E-8 2.773E-8 3 3
4 GO:1990459 transferrin receptor binding 2.347E-8 3.873E-7 1.849E-6 1.549E-6 3 8
5 GO:0005154 epidermal growth factor receptor binding 2.260E-6 2.725E-5 1.301E-4 1.491E-4 3 33
6 GO:0005158 insulin receptor binding 2.477E-6 2.725E-5 1.301E-4 1.635E-4 3 34
7 GO:0005537 mannose binding 1.023E-4 9.647E-4 4.606E-3 6.753E-3 2 19
8 GO:0070851 growth factor receptor binding 1.874E-4 1.546E-3 7.381E-3 1.237E-2 3 143
9 GO:0032266 phosphatidylinositol-3-phosphate binding 2.950E-4 2.163E-3 1.033E-2 1.947E-2 2 32
10 GO:0015578 mannose transmembrane transporter activity 8.038E-4 5.305E-3 2.533E-2
5.305E-2
 1 1
11 GO:0048029 monosaccharide binding 1.838E-3 1.103E-2
5.265E-2
1.213E-1
 2 80
12 GO:0005010 insulin-like growth factor-activated receptor activity 2.410E-3 1.325E-2
6.328E-2
1.590E-1
 1 3
13 GO:0008565 protein transporter activity 2.909E-3 1.477E-2
7.051E-2
1.920E-1
 2 101
14 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity 4.013E-3 1.766E-2
8.430E-2
2.649E-1
 1 5
15 GO:0016176 superoxide-generating NADPH oxidase activator activity 4.013E-3 1.766E-2
8.430E-2
2.649E-1
 1 5
16 GO:1901981 phosphatidylinositol phosphate binding 4.623E-3 1.869E-2
8.923E-2
3.051E-1
 2 128
17 GO:0031749 D2 dopamine receptor binding 4.814E-3 1.869E-2
8.923E-2
3.177E-1
 1 6
18 GO:0004630 phospholipase D activity 5.614E-3 2.016E-2
9.624E-2
3.705E-1
 1 7
19 GO:0034452 dynactin binding 6.414E-3 2.016E-2
9.624E-2
4.233E-1
 1 8
20 GO:0031995 insulin-like growth factor II binding 6.414E-3 2.016E-2
9.624E-2
4.233E-1
 1 8
21 GO:0071933 Arp2/3 complex binding 6.414E-3 2.016E-2
9.624E-2
4.233E-1
 1 8
22 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 9.606E-3 2.882E-2
1.376E-1
6.340E-1
 1 12
23 GO:0050750 low-density lipoprotein particle receptor binding 1.438E-2 4.034E-2
1.926E-1
9.489E-1
 1 18
24 GO:0015149 hexose transmembrane transporter activity 1.517E-2 4.034E-2
1.926E-1
1.000E0
 1 19
25 GO:0015145 monosaccharide transmembrane transporter activity 1.675E-2 4.034E-2
1.926E-1
1.000E0
 1 21
26 GO:0050998 nitric-oxide synthase binding 1.755E-2 4.034E-2
1.926E-1
1.000E0
 1 22
27 GO:0005545 1-phosphatidylinositol binding 1.755E-2 4.034E-2
1.926E-1
1.000E0
 1 22
28 GO:0050780 dopamine receptor binding 1.755E-2 4.034E-2
1.926E-1
1.000E0
 1 22
29 GO:0070325 lipoprotein particle receptor binding 1.834E-2 4.034E-2
1.926E-1
1.000E0
 1 23
30 GO:0001972 retinoic acid binding 1.834E-2 4.034E-2
1.926E-1
1.000E0
 1 23
31 GO:0030246 carbohydrate binding 2.197E-2 4.595E-2
2.194E-1
1.000E0
 2 289
32 GO:0005520 insulin-like growth factor binding 2.228E-2 4.595E-2
2.194E-1
1.000E0
 1 28
33 GO:0051119 sugar transmembrane transporter activity 2.621E-2 4.942E-2
2.360E-1
1.000E0
 1 33
34 GO:0050699 WW domain binding 2.621E-2 4.942E-2
2.360E-1
1.000E0
 1 33
35 GO:0001965 G-protein alpha-subunit binding 2.621E-2 4.942E-2
2.360E-1
1.000E0
 1 33
Show 30 more annotations

2: GO: Biological Process [Display Chart] 15 input genes in category / 404 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016197 endosomal transport 3.957E-18 1.598E-15 1.052E-14 1.598E-15 11 259
2 GO:0007034 vacuolar transport 1.292E-17 2.610E-15 1.718E-14 5.221E-15 11 288
3 GO:1990126 retrograde transport, endosome to plasma membrane 2.714E-10 3.655E-8 2.405E-7 1.097E-7 4 14
4 GO:0042147 retrograde transport, endosome to Golgi 2.514E-9 2.539E-7 1.671E-6 1.016E-6 5 74
5 GO:0006898 receptor-mediated endocytosis 9.114E-8 7.364E-6 4.846E-5 3.682E-5 6 311
6 GO:0016050 vesicle organization 6.109E-6 3.873E-4 2.548E-3 2.468E-3 5 353
7 GO:0008333 endosome to lysosome transport 6.711E-6 3.873E-4 2.548E-3 2.711E-3 3 47
8 GO:0097581 lamellipodium organization 2.869E-5 1.392E-3 9.161E-3 1.159E-2 3 76
9 GO:0007041 lysosomal transport 3.102E-5 1.392E-3 9.161E-3 1.253E-2 3 78
10 GO:0034498 early endosome to Golgi transport 3.978E-5 1.607E-3 1.057E-2 1.607E-2 2 12
11 GO:0097320 plasma membrane tubulation 7.219E-5 2.430E-3 1.599E-2 2.917E-2 2 16
12 GO:0072673 lamellipodium morphogenesis 7.219E-5 2.430E-3 1.599E-2 2.917E-2 2 16
13 GO:0006907 pinocytosis 1.260E-4 3.667E-3 2.413E-2
5.092E-2
 2 21
14 GO:0048193 Golgi vesicle transport 1.271E-4 3.667E-3 2.413E-2
5.133E-2
 4 340
15 GO:1903335 regulation of vacuolar transport 2.428E-4 6.539E-3 4.302E-2
9.808E-2
 2 29
16 GO:0032456 endocytic recycling 2.962E-4 7.479E-3 4.921E-2
1.197E-1
 2 32
17 GO:0030100 regulation of endocytosis 7.204E-4 1.627E-2
1.071E-1
2.911E-1
 3 226
18 GO:0015761 mannose transmembrane transport 8.055E-4 1.627E-2
1.071E-1
3.254E-1
 1 1
19 GO:1903408 positive regulation of sodium:potassium-exchanging ATPase activity 8.055E-4 1.627E-2
1.071E-1
3.254E-1
 1 1
20 GO:0001770 establishment of natural killer cell polarity 8.055E-4 1.627E-2
1.071E-1
3.254E-1
 1 1
21 GO:0035904 aorta development 8.458E-4 1.627E-2
1.071E-1
3.417E-1
 2 54
22 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 1.377E-3 2.243E-2
1.476E-1
5.563E-1
 2 69
23 GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus 1.377E-3 2.243E-2
1.476E-1
5.563E-1
 2 69
24 GO:0060976 coronary vasculature development 1.377E-3 2.243E-2
1.476E-1
5.563E-1
 2 69
25 GO:1902823 negative regulation of late endosome to lysosome transport 1.610E-3 2.243E-2
1.476E-1
6.506E-1
 1 2
26 GO:1903526 negative regulation of membrane tubulation 1.610E-3 2.243E-2
1.476E-1
6.506E-1
 1 2
27 GO:0061357 positive regulation of Wnt protein secretion 1.610E-3 2.243E-2
1.476E-1
6.506E-1
 1 2
28 GO:0071245 cellular response to carbon monoxide 1.610E-3 2.243E-2
1.476E-1
6.506E-1
 1 2
29 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity 1.610E-3 2.243E-2
1.476E-1
6.506E-1
 1 2
30 GO:0050764 regulation of phagocytosis 2.128E-3 2.636E-2
1.735E-1
8.599E-1
 2 86
31 GO:0031623 receptor internalization 2.277E-3 2.636E-2
1.735E-1
9.200E-1
 2 89
32 GO:0060840 artery development 2.328E-3 2.636E-2
1.735E-1
9.405E-1
 2 90
33 GO:0061355 Wnt protein secretion 2.415E-3 2.636E-2
1.735E-1
9.755E-1
 1 3
34 GO:0060988 lipid tube assembly 2.415E-3 2.636E-2
1.735E-1
9.755E-1
 1 3
35 GO:0061356 regulation of Wnt protein secretion 2.415E-3 2.636E-2
1.735E-1
9.755E-1
 1 3
36 GO:0006624 vacuolar protein processing 2.415E-3 2.636E-2
1.735E-1
9.755E-1
 1 3
37 GO:1903595 positive regulation of histamine secretion by mast cell 2.415E-3 2.636E-2
1.735E-1
9.755E-1
 1 3
38 GO:0006892 post-Golgi vesicle-mediated transport 2.589E-3 2.753E-2
1.811E-1
1.000E0
 2 95
39 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 3.152E-3 2.889E-2
1.901E-1
1.000E0
 2 105
40 GO:0003279 cardiac septum development 3.152E-3 2.889E-2
1.901E-1
1.000E0
 2 105
41 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 3.152E-3 2.889E-2
1.901E-1
1.000E0
 2 105
42 GO:1903525 regulation of membrane tubulation 3.218E-3 2.889E-2
1.901E-1
1.000E0
 1 4
43 GO:1903336 negative regulation of vacuolar transport 3.218E-3 2.889E-2
1.901E-1
1.000E0
 1 4
44 GO:2001137 positive regulation of endocytic recycling 3.218E-3 2.889E-2
1.901E-1
1.000E0
 1 4
45 GO:1902822 regulation of late endosome to lysosome transport 3.218E-3 2.889E-2
1.901E-1
1.000E0
 1 4
46 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.452E-3 3.032E-2
1.995E-1
1.000E0
 2 110
47 GO:0034465 response to carbon monoxide 4.021E-3 3.457E-2
2.274E-1
1.000E0
 1 5
48 GO:0030031 cell projection assembly 4.702E-3 3.898E-2
2.565E-1
1.000E0
 3 436
49 GO:1903593 regulation of histamine secretion by mast cell 4.824E-3 3.898E-2
2.565E-1
1.000E0
 1 6
50 GO:1902774 late endosome to lysosome transport 4.824E-3 3.898E-2
2.565E-1
1.000E0
 1 6
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 15 input genes in category / 88 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044440 endosomal part 9.462E-16 8.326E-14 4.213E-13 8.326E-14 11 434
2 GO:0005769 early endosome 3.563E-15 1.568E-13 7.933E-13 3.135E-13 10 314
3 GO:0030904 retromer complex 7.539E-15 2.211E-13 1.119E-12 6.634E-13 6 23
4 GO:0010008 endosome membrane 3.952E-14 8.694E-13 4.399E-12 3.478E-12 10 399
5 GO:0031901 early endosome membrane 1.919E-10 3.378E-9 1.709E-8 1.689E-8 6 114
6 GO:0030905 retromer, tubulation complex 1.576E-9 2.312E-8 1.170E-7 1.387E-7 3 4
7 GO:0031252 cell leading edge 2.978E-7 3.744E-6 1.894E-5 2.621E-5 6 389
8 GO:0005770 late endosome 5.848E-7 6.433E-6 3.255E-5 5.146E-5 5 224
9 GO:0030139 endocytic vesicle 1.340E-6 1.311E-5 6.632E-5 1.179E-4 5 265
10 GO:0019898 extrinsic component of membrane 1.696E-6 1.493E-5 7.553E-5 1.493E-4 5 278
11 GO:0030906 retromer, cargo-selective complex 3.465E-6 2.715E-5 1.374E-4 3.049E-4 2 4
12 GO:0098791 Golgi subcompartment 3.702E-6 2.715E-5 1.374E-4 3.258E-4 5 326
13 GO:0031984 organelle subcompartment 4.612E-6 3.122E-5 1.580E-4 4.058E-4 5 341
14 GO:0097422 tubular endosome 5.772E-6 3.628E-5 1.836E-4 5.080E-4 2 5
15 GO:0030027 lamellipodium 1.102E-5 6.463E-5 3.270E-4 9.695E-4 4 186
16 GO:0005802 trans-Golgi network 1.985E-5 1.092E-4 5.524E-4 1.747E-3 4 216
17 GO:0098852 lytic vacuole membrane 5.251E-5 2.567E-4 1.299E-3 4.621E-3 4 277
18 GO:0005765 lysosomal membrane 5.251E-5 2.567E-4 1.299E-3 4.621E-3 4 277
19 GO:0001891 phagocytic cup 9.808E-5 4.543E-4 2.299E-3 8.631E-3 2 19
20 GO:0030136 clathrin-coated vesicle 2.544E-4 1.119E-3 5.663E-3 2.238E-2 3 162
21 GO:0001726 ruffle 2.881E-4 1.207E-3 6.108E-3 2.535E-2 3 169
22 GO:0070685 macropinocytic cup 7.869E-4 3.106E-3 1.571E-2
6.925E-2
 1 1
23 GO:0030135 coated vesicle 8.117E-4 3.106E-3 1.571E-2
7.143E-2
 3 241
24 GO:0032588 trans-Golgi network membrane 1.851E-3 6.787E-3 3.435E-2
1.629E-1
 2 82
25 GO:0045335 phagocytic vesicle 2.128E-3 7.490E-3 3.790E-2
1.873E-1
 2 88
26 GO:0020016 ciliary pocket 2.359E-3 7.689E-3 3.891E-2
2.076E-1
 1 3
27 GO:0020018 ciliary pocket membrane 2.359E-3 7.689E-3 3.891E-2
2.076E-1
 1 3
28 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 3.125E-3 9.822E-3 4.970E-2
2.750E-1
 2 107
29 GO:0032010 phagolysosome 3.929E-3 1.152E-2
5.832E-2
3.457E-1
 1 5
30 GO:0031313 extrinsic component of endosome membrane 3.929E-3 1.152E-2
5.832E-2
3.457E-1
 1 5
31 GO:0019897 extrinsic component of plasma membrane 6.197E-3 1.675E-2
8.473E-2
5.453E-1
 2 152
32 GO:0005767 secondary lysosome 6.279E-3 1.675E-2
8.473E-2
5.526E-1
 1 8
33 GO:0000306 extrinsic component of vacuolar membrane 6.279E-3 1.675E-2
8.473E-2
5.526E-1
 1 8
34 GO:0031095 platelet dense tubular network membrane 7.062E-3 1.828E-2
9.249E-2
6.214E-1
 1 9
35 GO:0009898 cytoplasmic side of plasma membrane 7.606E-3 1.912E-2
9.678E-2
6.694E-1
 2 169
36 GO:0043020 NADPH oxidase complex 7.844E-3 1.917E-2
9.702E-2
6.902E-1
 1 10
37 GO:0031094 platelet dense tubular network 8.625E-3 2.051E-2
1.038E-1
7.590E-1
 1 11
38 GO:0098562 cytoplasmic side of membrane 8.960E-3 2.069E-2
1.047E-1
7.885E-1
 2 184
39 GO:0005641 nuclear envelope lumen 9.405E-3 2.069E-2
1.047E-1
8.277E-1
 1 12
40 GO:0071203 WASH complex 9.405E-3 2.069E-2
1.047E-1
8.277E-1
 1 12
41 GO:0014069 postsynaptic density 1.395E-2 2.924E-2
1.479E-1
1.000E0
 2 232
42 GO:0099572 postsynaptic specialization 1.395E-2 2.924E-2
1.479E-1
1.000E0
 2 232
43 GO:0005868 cytoplasmic dynein complex 1.485E-2 3.040E-2
1.538E-1
1.000E0
 1 19
44 GO:0060076 excitatory synapse 1.632E-2 3.264E-2
1.652E-1
1.000E0
 2 252
45 GO:0030140 trans-Golgi network transport vesicle 2.336E-2 4.568E-2
2.311E-1
1.000E0
 1 30
46 GO:0031312 extrinsic component of organelle membrane 2.567E-2 4.910E-2
2.485E-1
1.000E0
 1 33
Show 41 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 512 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 12 input genes in category / 361 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020515 abnormal visceral yolk sac endoderm morphology 8.074E-5 2.915E-2
1.885E-1
 2.915E-2 2 12

6: Domain [Display Chart] 15 input genes in category / 104 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00312 PX SMART 4.491E-21 4.671E-19 2.441E-18 4.671E-19 9 44
2 PF00787 PX Pfam 1.300E-20 4.836E-19 2.528E-18 1.352E-18 9 49
3 PS50195 PX PROSITE 1.584E-20 4.836E-19 2.528E-18 1.648E-18 9 50
4 3.30.1520.10 - Gene3D 1.923E-20 4.836E-19 2.528E-18 2.000E-18 9 51
5 IPR001683 Phox InterPro 2.325E-20 4.836E-19 2.528E-18 2.418E-18 9 52
6 PF09325 Vps5 Pfam 4.148E-9 6.163E-8 3.221E-7 4.314E-7 3 5
7 IPR015404 Vps5 C InterPro 4.148E-9 6.163E-8 3.221E-7 4.314E-7 3 5
8 IPR005329 Sorting nexin N InterPro 5.983E-7 6.914E-6 3.614E-5 6.223E-5 2 2
9 PF03700 Sorting nexin Pfam 5.983E-7 6.914E-6 3.614E-5 6.223E-5 2 2
10 2.70.130.10 - Gene3D 8.958E-6 9.317E-5 4.869E-4 9.317E-4 2 6
11 IPR009011 Man6P isomerase rcpt-bd dom InterPro 1.671E-5 1.580E-4 8.255E-4 1.737E-3 2 8
12 IPR030381 G DYNAMIN dom InterPro 5.415E-5 4.059E-4 2.121E-3 5.631E-3 2 14
13 PS51718 G DYNAMIN 2 PROSITE 5.415E-5 4.059E-4 2.121E-3 5.631E-3 2 14
14 IPR022812 Dynamin SF InterPro 6.245E-5 4.059E-4 2.121E-3 6.494E-3 2 15
15 PF00350 Dynamin N Pfam 6.245E-5 4.059E-4 2.121E-3 6.494E-3 2 15
16 IPR001401 Dynamin GTPase InterPro 6.245E-5 4.059E-4 2.121E-3 6.494E-3 2 15
17 PS50200 RA PROSITE 3.921E-4 2.250E-3 1.176E-2 4.078E-2 2 37
18 IPR000159 RA dom InterPro 4.586E-4 2.250E-3 1.176E-2 4.769E-2 2 40
19 PF00878 CIMR Pfam 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
20 IPR024654 Calcineurin-like PHP lpxH InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
21 IPR028927 Man-6-P rcpt InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
22 IPR028644 SNX9 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
23 IPR000979 Phosphodiesterase MJ0936/Vps29 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
24 PF12850 Metallophos 2 Pfam 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
25 IPR028666 SNX17 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
26 IPR000296 Man 6 P rcpt InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
27 IPR027188 DNM2 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
28 IPR028653 SNX2 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
29 IPR028654 SNX5 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
30 IPR028667 SNX27 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
31 SM01404 CIMR SMART 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
32 PF02157 Man-6-P recep Pfam 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
33 PF03635 Vps35 Pfam 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
34 IPR000919 NCF P40 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
35 IPR028660 SNX1 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
36 IPR005378 Vps35 InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
37 IPR000479 CIMR InterPro 8.006E-4 2.250E-3 1.176E-2
8.327E-2
 1 1
38 IPR016555 PLipase D1/D2 InterPro 1.601E-3 4.162E-3 2.175E-2
1.665E-1
 1 2
39 IPR015679 PLipase D fam InterPro 1.601E-3 4.162E-3 2.175E-2
1.665E-1
 1 2
40 IPR029951 EHD1/EHD3 InterPro 1.601E-3 4.162E-3 2.175E-2
1.665E-1
 1 2
41 IPR019497 Sorting nexin WASP-bd-dom InterPro 2.400E-3 5.426E-3 2.836E-2
2.496E-1
 1 3
42 IPR025202 PLD-like dom InterPro 2.400E-3 5.426E-3 2.836E-2
2.496E-1
 1 3
43 IPR014637 SNX5/SNX6/SNX32 InterPro 2.400E-3 5.426E-3 2.836E-2
2.496E-1
 1 3
44 PF13091 PLDc 2 Pfam 2.400E-3 5.426E-3 2.836E-2
2.496E-1
 1 3
45 PF10456 BAR 3 WASP bdg Pfam 2.400E-3 5.426E-3 2.836E-2
2.496E-1
 1 3
46 IPR014536 Snx9 subfam InterPro 2.400E-3 5.426E-3 2.836E-2
2.496E-1
 1 3
47 PF00614 PLDc Pfam 3.199E-3 7.079E-3 3.700E-2
3.327E-1
 1 4
48 PF16880 EHD N Pfam 3.997E-3 8.484E-3 4.434E-2
4.157E-1
 1 5
49 IPR031692 EHD N InterPro 3.997E-3 8.484E-3 4.434E-2
4.157E-1
 1 5
50 PF02212 GED Pfam 4.795E-3 8.598E-3 4.494E-2
4.987E-1
 1 6
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 87 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 102279 Endocytosis BioSystems: KEGG 3.596E-15 3.129E-13 1.580E-12 3.129E-13 10 260
2 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 5.474E-11 1.588E-9 8.015E-9 4.763E-9 6 73
3 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 5.474E-11 1.588E-9 8.015E-9 4.763E-9 6 73
4 1269882 Golgi Associated Vesicle Biogenesis BioSystems: REACTOME 2.104E-9 4.576E-8 2.311E-7 1.831E-7 5 57
5 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 9.290E-6 1.616E-4 8.161E-4 8.082E-4 4 137
6 1269595 WNT ligand biogenesis and trafficking BioSystems: REACTOME 3.481E-4 5.048E-3 2.549E-2 3.029E-2 2 27
7 1269883 Lysosome Vesicle Biogenesis BioSystems: REACTOME 6.215E-4 7.725E-3 3.900E-2
5.407E-2
 2 36
8 137954 Arf6 trafficking events BioSystems: Pathway Interaction Database 9.289E-4 1.002E-2
5.057E-2
8.081E-2
 2 44
9 142173 serine biosynthesis (phosphorylated route) BioSystems: BIOCYC 1.044E-3 1.002E-2
5.057E-2
9.084E-2
 1 1
10 1383039 Retrograde transport at the Trans-Golgi-Network BioSystems: REACTOME 1.151E-3 1.002E-2
5.057E-2
1.002E-1
 2 49
11 114228 Fc gamma R-mediated phagocytosis BioSystems: KEGG 3.911E-3 3.024E-2
1.527E-1
3.403E-1
 2 91
12 142128 serine and glycine biosynthesis BioSystems: BIOCYC 4.171E-3 3.024E-2
1.527E-1
3.628E-1
 1 4
13 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 4.612E-3 3.086E-2
1.558E-1
4.012E-1
 2 99
14 1270119 NOSTRIN mediated eNOS trafficking BioSystems: REACTOME 5.211E-3 3.238E-2
1.635E-1
4.533E-1
 1 5
15 99052 Lysosome BioSystems: KEGG 7.033E-3 4.079E-2
2.059E-1
6.118E-1
 2 123
16 1269196 Cross-presentation of particulate exogenous antigens (phagosomes) BioSystems: REACTOME 8.325E-3 4.261E-2
2.151E-1
7.243E-1
 1 8
17 1270068 Synthesis of PG BioSystems: REACTOME 8.325E-3 4.261E-2
2.151E-1
7.243E-1
 1 8
18 1269892 Formation of annular gap junctions BioSystems: REACTOME 9.361E-3 4.482E-2
2.263E-1
8.144E-1
 1 9
19 1311074 Phospholipase D signaling pathway BioSystems: KEGG 9.788E-3 4.482E-2
2.263E-1
8.516E-1
 2 146
20 1269891 Gap junction degradation BioSystems: REACTOME 1.040E-2 4.492E-2
2.268E-1
9.045E-1
 1 10
21 153910 Phagosome BioSystems: KEGG 1.084E-2 4.492E-2
2.268E-1
9.433E-1
 2 154
Show 16 more annotations

8: Pubmed [Display Chart] 15 input genes in category / 1409 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17101778 Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Pubmed 2.661E-17 3.749E-14 2.935E-13 3.749E-14 5 6
2 26220253 Retromer: Structure, function, and roles in mammalian disease. Pubmed 2.482E-16 1.749E-13 1.369E-12 3.497E-13 5 8
3 19619496 The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Pubmed 5.584E-16 2.622E-13 2.053E-12 7.867E-13 5 9
4 11485546 A large family of endosome-localized proteins related to sorting nexin 1. Pubmed 2.737E-14 9.643E-12 7.548E-11 3.857E-11 5 17
5 11102511 Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Pubmed 2.309E-13 6.506E-11 5.093E-10 3.253E-10 4 6
6 27385586 Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation. Pubmed 1.938E-12 4.551E-10 3.563E-9 2.731E-9 4 9
7 17891154 Functional architecture of the retromer cargo-recognition complex. Pubmed 1.960E-10 3.945E-8 3.088E-7 2.761E-7 3 4
8 18656452 Identification of novel retromer complexes in the mouse testis. Pubmed 4.898E-10 7.668E-8 6.003E-7 6.902E-7 3 5
9 16214895 Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Pubmed 4.898E-10 7.668E-8 6.003E-7 6.902E-7 3 5
10 23085988 Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. Pubmed 1.714E-9 2.414E-7 1.890E-6 2.414E-6 3 7
11 9819414 Identification of a family of sorting nexin molecules and characterization of their association with receptors. Pubmed 4.111E-9 5.265E-7 4.122E-6 5.792E-6 3 9
12 20923837 The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. Pubmed 5.871E-9 6.894E-7 5.396E-6 8.272E-6 3 10
13 15078902 Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. Pubmed 1.076E-8 1.166E-6 9.128E-6 1.516E-5 3 12
14 11278302 Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. Pubmed 1.779E-8 1.791E-6 1.402E-5 2.507E-5 3 14
15 11279102 Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Pubmed 2.736E-8 2.570E-6 2.012E-5 3.855E-5 3 16
16 17983586 Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Pubmed 4.731E-8 4.166E-6 3.261E-5 6.666E-5 3 19
17 10799489 Function and properties of chimeric MPR 46-MPR 300 mannose 6-phosphate receptors. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
18 1319896 Expression of the two mannose 6-phosphate receptors is spatially and temporally different during mouse embryogenesis. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
19 26202251 A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
20 1322799 Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
21 12388759 Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
22 1848553 Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
23 11062004 Human homologues of yeast vacuolar protein sorting 29 and 35. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
24 28252385 Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
25 15167696 Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
26 10601243 Mutational analysis of the binding site residues of the bovine cation-dependent mannose 6-phosphate receptor. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
27 15121882 Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
28 11105922 Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
29 15299020 Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
30 8584025 Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
31 8707842 Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
32 15371683 Unimpaired allorejection of cells deficient for the mannose 6-phosphate receptors Mpr300 and Mpr46. Pubmed 1.440E-7 6.339E-6 4.962E-5 2.028E-4 2 2
33 25475142 Genetic variability of the retromer cargo recognition complex in parkinsonism. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
34 26965691 Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
35 15965486 Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
36 9590177 TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
37 15673616 Determinants of the endosomal localization of sorting nexin 1. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
38 17319803 Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
39 12952949 Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
40 14585283 Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
41 8001817 Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
42 15703209 SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
43 20604901 A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
44 18088323 SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
45 8088706 Insulin-like growth factor II (IGF-II) and the IGF-II/mannose-6-phosphate receptor: the myth continues. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
46 15247922 The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
47 21602791 SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
48 10212152 Alternative mechanisms for trafficking of lysosomal enzymes in mannose 6-phosphate receptor-deficient mice are cell type-specific. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
49 24747528 Pharmacological chaperones stabilize retromer to limit APP processing. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
50 14985351 Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells. Pubmed 4.318E-7 1.106E-5 8.660E-5 6.084E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 15 input genes in category / 674 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SNX2 SNX2 interactions 7.526E-11 5.072E-8 3.597E-7 5.072E-8 6 91
2 int:VPS26B VPS26B interactions 3.119E-10 7.216E-8 5.117E-7 2.102E-7 5 47
3 int:DNM3 DNM3 interactions 3.480E-10 7.216E-8 5.117E-7 2.345E-7 5 48
4 int:INSR INSR interactions 4.283E-10 7.216E-8 5.117E-7 2.886E-7 6 121
5 int:SNX6 SNX6 interactions 2.617E-9 3.528E-7 2.502E-6 1.764E-6 5 71
6 int:SNX1 SNX1 interactions 3.234E-9 3.632E-7 2.576E-6 2.179E-6 5 74
7 int:VPS26A VPS26A interactions 1.650E-8 1.589E-6 1.127E-5 1.112E-5 5 102
8 int:ATP6V1C1 ATP6V1C1 interactions 1.930E-7 1.626E-5 1.153E-4 1.301E-4 4 63
9 int:GNAT2 GNAT2 interactions 2.738E-7 2.050E-5 1.454E-4 1.845E-4 3 16
10 int:C1orf87 C1orf87 interactions 3.985E-7 2.686E-5 1.905E-4 2.686E-4 3 18
11 int:VPS35 VPS35 interactions 6.187E-7 3.791E-5 2.688E-4 4.170E-4 4 84
12 int:VPS29 VPS29 interactions 8.168E-7 4.588E-5 3.253E-4 5.505E-4 4 90
13 int:LEPR LEPR interactions 1.422E-6 7.373E-5 5.228E-4 9.585E-4 3 27
14 int:C11orf42 C11orf42 interactions 2.009E-6 9.674E-5 6.860E-4 1.354E-3 2 3
15 int:WDFY1 WDFY1 interactions 3.169E-6 1.335E-4 9.467E-4 2.136E-3 3 35
16 int:VPS33B VPS33B interactions 3.169E-6 1.335E-4 9.467E-4 2.136E-3 3 35
17 int:FAM129B FAM129B interactions 3.758E-6 1.490E-4 1.057E-3 2.533E-3 3 37
18 int:FAM221A FAM221A interactions 6.691E-6 2.506E-4 1.777E-3 4.510E-3 2 5
19 int:SNX5 SNX5 interactions 7.309E-6 2.593E-4 1.839E-3 4.926E-3 3 46
20 int:GGA3 GGA3 interactions 7.804E-6 2.630E-4 1.865E-3 5.260E-3 3 47
21 int:FAM90A1 FAM90A1 interactions 1.189E-5 3.818E-4 2.707E-3 8.017E-3 3 54
22 int:GGA1 GGA1 interactions 3.204E-5 9.815E-4 6.960E-3 2.159E-2 3 75
23 int:BIN1 BIN1 interactions 3.604E-5 1.030E-3 7.307E-3 2.429E-2 3 78
24 int:SELP SELP interactions 3.669E-5 1.030E-3 7.307E-3 2.473E-2 2 11
25 int:FCHSD1 FCHSD1 interactions 4.401E-5 1.099E-3 7.791E-3 2.966E-2 2 12
26 int:SAC3D1 SAC3D1 interactions 4.401E-5 1.099E-3 7.791E-3 2.966E-2 2 12
27 int:SNX32 SNX32 interactions 4.401E-5 1.099E-3 7.791E-3 2.966E-2 2 12
28 int:HGS HGS interactions 4.837E-5 1.164E-3 8.256E-3 3.260E-2 4 252
29 int:PDGFRA PDGFRA interactions 6.707E-5 1.559E-3 1.105E-2 4.520E-2 3 96
30 int:RHEX RHEX interactions 6.992E-5 1.571E-3 1.114E-2 4.712E-2 2 15
31 int:WASHC2C WASHC2C interactions 7.986E-5 1.736E-3 1.231E-2
5.383E-2
 2 16
32 int:PDGFRB PDGFRB interactions 1.033E-4 2.176E-3 1.543E-2
6.964E-2
 3 111
33 int:TBC1D5 TBC1D5 interactions 1.533E-4 3.131E-3 2.220E-2
1.033E-1
 2 22
34 int:BIN3 BIN3 interactions 1.678E-4 3.326E-3 2.359E-2
1.131E-1
 2 23
35 int:AP2A1 AP2A1 interactions 1.886E-4 3.632E-3 2.575E-2
1.271E-1
 3 136
36 int:CTTN CTTN interactions 2.142E-4 3.818E-3 2.707E-2
1.444E-1
 3 142
37 int:SNX4 SNX4 interactions 2.152E-4 3.818E-3 2.707E-2
1.451E-1
 2 26
38 int:MLX MLX interactions 2.152E-4 3.818E-3 2.707E-2
1.451E-1
 2 26
39 int:POTEB3 POTEB3 interactions 2.323E-4 4.015E-3 2.847E-2
1.566E-1
 2 27
40 int:FNBP1 FNBP1 interactions 3.072E-4 5.050E-3 3.581E-2
2.071E-1
 2 31
41 int:HCLS1 HCLS1 interactions 3.072E-4 5.050E-3 3.581E-2
2.071E-1
 2 31
42 int:PCID2 PCID2 interactions 3.275E-4 5.256E-3 3.727E-2
2.208E-1
 2 32
43 int:VPS25 VPS25 interactions 3.485E-4 5.462E-3 3.873E-2
2.349E-1
 2 33
44 int:KLHL10 KLHL10 interactions 3.701E-4 5.669E-3 4.020E-2
2.494E-1
 2 34
45 int:H3F3A H3F3A interactions 3.828E-4 5.733E-3 4.065E-2
2.580E-1
 3 173
46 int:TSN TSN interactions 3.923E-4 5.748E-3 4.076E-2
2.644E-1
 2 35
47 int:ANP32E ANP32E interactions 4.152E-4 5.954E-3 4.222E-2
2.798E-1
 2 36
48 int:VPS36 VPS36 interactions 4.387E-4 6.160E-3 4.368E-2
2.957E-1
 2 37
49 int:ARFIP2 ARFIP2 interactions 5.391E-4 7.267E-3
5.153E-2
3.634E-1
 2 41
50 int:ANKFY1 ANKFY1 interactions 5.391E-4 7.267E-3
5.153E-2
3.634E-1
 2 41
Show 45 more annotations

10: Cytoband [Display Chart] 15 input genes in category / 15 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q25.1-q26 6q25.1-q26 4.328E-4 6.490E-3 2.154E-2 6.491E-3 1 1
2 2p23-p22 2p23-p22 8.654E-4 6.490E-3 2.154E-2 1.298E-2 1 2
3 20p11 20p11 2.162E-3 7.564E-3 2.510E-2 3.243E-2 1 5
4 16q12 16q12 2.594E-3 7.564E-3 2.510E-2 3.891E-2 1 6
5 5q23 5q23 3.026E-3 7.564E-3 2.510E-2 4.539E-2 1 7
6 3q26 3q26 3.026E-3 7.564E-3 2.510E-2 4.539E-2 1 7
7 6q26 6q26 7.763E-3 1.664E-2
5.520E-2
1.164E-1
 1 18
8 3q21.2 3q21.2 9.481E-3 1.778E-2
5.898E-2
1.422E-1
 1 22
9 12q24 12q24 1.077E-2 1.794E-2
5.954E-2
1.615E-1
 1 25
10 15q22.31 15q22.31 1.803E-2 2.704E-2
8.972E-2
2.704E-1
 1 42
11 12p13 12p13 2.819E-2 3.844E-2
1.276E-1
4.229E-1
 1 66
12 22q13.1 22q13.1 3.784E-2 4.730E-2
1.569E-1
5.676E-1
 1 89
Show 7 more annotations

11: Transcription Factor Binding Site [Display Chart] 14 input genes in category / 90 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 13 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 754 Sorting nexins genenames.org 2.035E-17 2.035E-16 5.960E-16 2.035E-16 7 29
2 1290 Sorting nexins|Autophagy related|PX-BAR domain containing genenames.org 6.123E-14 3.062E-13 8.967E-13 6.123E-13 5 12
3 1233 MRH domain containing genenames.org 7.058E-6 2.353E-5 6.891E-5 7.058E-5 2 6
4 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 9.166E-3 2.275E-2
6.664E-2
9.166E-2
 2 206
5 672 Parkinson disease associated genes|Ubiquitin C-terminal hydrolases genenames.org 1.138E-2 2.275E-2
6.664E-2
1.138E-1
 1 16
6 1022 Autophagy related genenames.org 2.333E-2 3.889E-2
1.139E-1
2.333E-1
 1 33
7 467 Phospholipases genenames.org 2.961E-2 4.230E-2
1.239E-1
2.961E-1
 1 42
Show 2 more annotations

13: Coexpression [Display Chart] 15 input genes in category / 1676 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17856 The 'MLL signature 1': genes up-regulated in pediatric AML (acute myeloid leukemia) with rearranged MLL [GeneID=4297] compared to all AML cases with the intact gene. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.053E-6 1.643E-3 1.315E-2 5.116E-3 5 380
2 M8550 Genes up-regulated in CD8 T cells: KLRB1 high [GeneID=3820] versus KLRB1 int [GeneID=3820]. MSigDB C7: Immunologic Signatures (v6.0) 6.864E-6 1.643E-3 1.315E-2 1.150E-2 4 200
3 M5237 Genes down-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 6.864E-6 1.643E-3 1.315E-2 1.150E-2 4 200
4 M8547 Genes up-regulated in KLRB1 high [GeneID=3820] T cells: CD8A [GeneID=925] versus CD8A CD8B [GeneID=925;926]. MSigDB C7: Immunologic Signatures (v6.0) 6.864E-6 1.643E-3 1.315E-2 1.150E-2 4 200
5 M4492 Genes down-regulated in comparison of naive CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 6.864E-6 1.643E-3 1.315E-2 1.150E-2 4 200
6 M7760 Genes up-regulated in macrophages: wildtype versus MYD88 [GeneID=4615] knockout. MSigDB C7: Immunologic Signatures (v6.0) 6.864E-6 1.643E-3 1.315E-2 1.150E-2 4 200
7 M8518 Genes down-regulated in CD8 T cells: ID3 [GeneID=3399] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 6.864E-6 1.643E-3 1.315E-2 1.150E-2 4 200
8 M7182 Genes down-regulated in hepatocellular carcinoma (HCC) with early recurrence. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.223E-6 1.723E-3 1.378E-2 1.378E-2 2 7
9 M5910 Genes involved in protein secretion pathway. MSigDB H: Hallmark Gene Sets (v6.0) 3.038E-5 5.107E-3 4.087E-2
5.091E-2
 3 96
10 M1782 Genes gradually up-regulated by histamine [PubChem=774] in B16-F10 melanoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.047E-5 5.107E-3 4.087E-2
5.107E-2
 2 13
11 M2289 Up-regulated target genes shared by acute myeloid leukemia (AML) translocation products PML RARA [GeneID=5371;5914], AML1 ETO [GeneID=861;862], and PLZF RARA [GeneID=5914;7704]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.554E-5 5.415E-3 4.333E-2
5.956E-2
 2 14
12 17096850-TableS3 Human Lung Balko06 130genes GeneSigDB 7.168E-5 1.001E-2
8.011E-2
1.201E-1
 3 128
13 M2914 Genes up-regulated in skin from INFG [GeneID=3458] knockout mice after injection of: control versus Trypanosoma cruzi (strain Y). MSigDB C7: Immunologic Signatures (v6.0) 1.289E-4 1.045E-2
8.363E-2
2.160E-1
 3 156
14 M8900 Genes down-regulated in pro-B cells versus RAG2 [GeneID=5897] knockout NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.935E-4 1.045E-2
8.363E-2
3.243E-1
 3 179
15 M10008 Genes down-regulated in NK cells versus CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.271E-4 1.045E-2
8.363E-2
3.806E-1
 3 189
16 15474998-tableS1a Mouse StemCell Lindmark04 624genes GeneSigDB 2.306E-4 1.045E-2
8.363E-2
3.865E-1
 4 493
17 M4436 Genes down-regulated in comparison of naive B cells versus memory IgM B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.565E-4 1.045E-2
8.363E-2
4.299E-1
 3 197
18 M3981 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 2.642E-4 1.045E-2
8.363E-2
4.428E-1
 3 199
19 M6584 Genes up-regulated in unstimulated monocytes versus macrophages incubated with CSF1 [GeneID=435] at day 7. MSigDB C7: Immunologic Signatures (v6.0) 2.642E-4 1.045E-2
8.363E-2
4.428E-1
 3 199
20 M7228 Genes down-regulated in T cells treated with IL21 [GeneID=59067]: 6h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 2.642E-4 1.045E-2
8.363E-2
4.428E-1
 3 199
21 M5776 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from patients with type 1 diabetes at the time of diagnosis. MSigDB C7: Immunologic Signatures (v6.0) 2.642E-4 1.045E-2
8.363E-2
4.428E-1
 3 199
22 M8070 Genes down-regulated in thymic implants from fetal versus those from adult bone marrow. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
23 M8522 Genes up-regulated CD8 T cells: mock transduced versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
24 M4600 Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3 versus CD25- T cells incubated with IL4 [GeneID=3565] at day 3. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
25 M6950 Genes up-regulated in plasmacytoid dendritic cells (1h): CpG oligodeoxynucleotide 1826 versus influenza virus infection. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
26 M7036 Genes down-regulated in hematopoietic stem cells: wildtype versus IKZF1 [GeneID=10320] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
27 M7080 Genes down-regulated in CD4 [GeneID=920] T cells from non-atopic donors: resting versus stimulated with allergen (house dust mite). MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
28 M8528 Genes up-regulated in macrophages: alternatively activated M2 versus MYC [GeneID=4609] inhibited. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
29 M9643 Genes up-regulated in CD4 [GeneID=920] T helper cells (10h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
30 M5132 Genes down-regulated in comparison of ex vivo CD8 dendritic cells versus cultured CD8 DCs. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
31 M9531 Genes up-regulated in skin with IL1R1 [GeneID=3554] knockout: uninfected versus S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
32 M7856 Genes up-regulated in CD4 [GeneID=920] T cells: untreated versus IL1B, IL6 [GeneID=3553;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
33 M8506 Genes down-regulated in CD8 T cells: over-expressing ID3 [GeneID=3399] versus ID3 [GeneID=3399] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
34 M9535 Genes down-regulated in skin: uninfected versus S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
35 M332 Genes down-regulated in Sez-2 cells (T cell lymphoma): untreated versus IL15 [GeneID=3600]. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
36 M5130 Genes down-regulated in comparison of ex vivo CD4 [GeneID=920] dendritic cells (DC) versus cultured CD4 [GeneID=920] DCs. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
37 M8068 Genes up-regulated in myeloid dendritic cells: hypoxia versus normoxia. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
38 M10003 Genes up-regulated during primary acute viral infection in dendritic cells: CD8A [GeneID=925] versus ITGAM+ [GeneID=3684]. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
39 M4343 Genes down-regulated in comparison of TregCD103-Klrg1- versus TregCD103+Klrg1+ (see Table 1S in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
40 M4476 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
41 M4966 Genes up-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
42 M7293 Genes down-regulated in lymphocytes treated with medium for 2h: T conv versus T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
43 M9943 Genes down-regulated in B lymphocytes treated by anti IgM for 6h: wildtype versus MAP3K7 [GeneID=6885] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.681E-4 1.045E-2
8.363E-2
4.494E-1
 3 200
44 M1668 Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls MSigDB C2: CGP Curated Gene Sets (v6.0) 4.170E-4 1.588E-2
1.271E-1
6.989E-1
 2 47
45 M13760 Genes up-regulated during differentiation from small pre-BII to immature B lymphocyte. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.236E-4 3.440E-2
2.752E-1
1.000E0
 2 70
46 M1549 Genes up-regulated in BJ cells (foreskin fibroblasts) immortalized by expression of TERT [GeneID=7015]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.145E-3 4.172E-2
3.338E-1
1.000E0
 2 78
47 19096012-TableS3 Human Viral Chetaille09 425genes GeneSigDB 1.342E-3 4.741E-2
3.793E-1
1.000E0
 3 348
48 M2021 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 2. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.358E-3 4.741E-2
3.793E-1
1.000E0
 2 85
49 15843827-TableS7 Human Leukemia Andersson05 114genes GeneSigDB 1.454E-3 4.974E-2
3.980E-1
1.000E0
 2 88
Show 44 more annotations

14: Coexpression Atlas [Display Chart] 15 input genes in category / 898 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Kidney10XCellRanger Six2TGC TSC1 E14 Stroma Stroma Subtype E14-Six2TGC Tsc1-Stroma1-C2-KC8 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Stroma Stroma Subtype E14-Six2TGC Tsc1-Stroma1-C2-KC8 Top 200 Genes 2.635E-6 2.366E-3 1.746E-2 2.366E-3 5 348
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/B cell Tabula Muris Consortium 6.612E-6 2.969E-3 2.190E-2 5.938E-3 4 187
3 Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype macrophage - intermediate - unactivated Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype macrophage - intermediate - unactivated Top 200 Genes 6.356E-5 1.674E-2
1.235E-1
5.708E-2
 4 333
4 GSM854229 500 B cells, B1a.Sp, CD19+ CD45R+ IgM++ AA4.1- CD23- CD43+ CD5+, Spleen, avg-3 Immgen.org, GSE15907 7.458E-5 1.674E-2
1.235E-1
6.697E-2
 4 347
5 Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes 1.255E-4 2.254E-2
1.663E-1
1.127E-1
 4 397
6 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/lymphocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/lymphocyte Tabula Muris Consortium 2.220E-4 3.265E-2
2.409E-1
1.993E-1
 3 177
7 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/B cell Tabula Muris Consortium 2.609E-4 3.265E-2
2.409E-1
2.343E-1
 3 187
8 Immune cells (IMM)/Immune cells (IMM) i Immune cells (IMM)/Immune cells (IMM) i 3.041E-4 3.265E-2
2.409E-1
2.730E-1
 3 197
9 Kidney10XCellRanger Six2KI P0 Unknown Unknown Subtype P0-Six2KI-Unknown-C4-KC9 Top 200 Genes Kidney10XCellRanger Six2KI P0 Unknown Unknown Subtype P0-Six2KI-Unknown-C4-KC9 Top 200 Genes 3.272E-4 3.265E-2
2.409E-1
2.939E-1
 3 202
10 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Podocyte (PD)/mid-fetal/PD a Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Podocyte (PD)/mid-fetal/PD a Fetal, Development 3.916E-4 3.295E-2
2.431E-1
3.516E-1
 2 43
11 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype macrophage - intermediate - unactivated PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype macrophage - intermediate - unactivated PND01-03 Top 200 Genes 4.036E-4 3.295E-2
2.431E-1
3.624E-1
 3 217
12 Kidney10XCellRanger Six2KI P0 Unknown Unknown Subtype P0-Six2KI-Unknown-C6-KC9 Top 200 Genes Kidney10XCellRanger Six2KI P0 Unknown Unknown Subtype P0-Six2KI-Unknown-C6-KC9 Top 200 Genes 4.663E-4 3.490E-2
2.575E-1
4.188E-1
 3 228
13 Lungmap Mouse Lung PND3 Immune Subtype Immune-B Lungmap Mouse Lung PND3 Immune Subtype Immune-B Lungmap CCHMC 5.683E-4 3.926E-2
2.896E-1
5.103E-1
 3 244
14 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Mature Myeloid E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Mature Myeloid E16.5 Top 200 Genes 7.792E-4 4.665E-2
3.442E-1
6.997E-1
 3 272
15 Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Mature Myeloid Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Myeloid Myeloid Subtype Mature Myeloid Top 200 Genes 7.792E-4 4.665E-2
3.442E-1
6.997E-1
 3 272
Show 10 more annotations

15: Computational [Display Chart] 13 input genes in category / 83 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 15 input genes in category / 597 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TTGCACT,MIR-130B:MSigDB TTGCACT,MIR-130B:MSigDB MSigDB 1.042E-8 2.074E-6 1.445E-5 6.221E-6 5 374
2 TTGCACT,MIR-130A:MSigDB TTGCACT,MIR-130A:MSigDB MSigDB 1.042E-8 2.074E-6 1.445E-5 6.221E-6 5 374
3 TTGCACT,MIR-301:MSigDB TTGCACT,MIR-301:MSigDB MSigDB 1.042E-8 2.074E-6 1.445E-5 6.221E-6 5 374
4 hsa-miR-342-3p:Functional MTI Functional MTI miRTarbase 3.234E-5 4.684E-3 3.265E-2 1.931E-2 3 304
5 hsa-miR-211-5p:Functional MTI Functional MTI miRTarbase 4.276E-5 4.684E-3 3.265E-2 2.553E-2 3 334
6 hsa-miR-130a-3p:Functional MTI Functional MTI miRTarbase 7.189E-5 4.684E-3 3.265E-2 4.292E-2 3 398
7 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 8.488E-5 4.684E-3 3.265E-2
5.067E-2
 3 421
8 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 8.488E-5 4.684E-3 3.265E-2
5.067E-2
 3 421
9 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 8.488E-5 4.684E-3 3.265E-2
5.067E-2
 3 421
10 hsa-miR-132*:mirSVR lowEffct hsa-miR-132*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.850E-5 4.684E-3 3.265E-2
5.284E-2
 3 427
11 hsa-miR-2909:mirSVR highEffct hsa-miR-2909:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.931E-5 4.684E-3 3.265E-2
5.929E-2
 3 444
12 hsa-miR-6822-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.020E-4 4.684E-3 3.265E-2
6.089E-2
 2 72
13 hsa-miR-6750-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.020E-4 4.684E-3 3.265E-2
6.089E-2
 2 72
14 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 1.273E-4 4.819E-3 3.359E-2
7.600E-2
 3 483
15 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 1.273E-4 4.819E-3 3.359E-2
7.600E-2
 3 483
16 hsa-miR-345-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.291E-4 4.819E-3 3.359E-2
7.710E-2
 2 81
17 AAACCAC,MIR-140:MSigDB AAACCAC,MIR-140:MSigDB MSigDB 2.008E-4 6.660E-3 4.642E-2
1.199E-1
 2 101
18 hsa-miR-497-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.008E-4 6.660E-3 4.642E-2
1.199E-1
 2 101
19 hsa-miR-1274a:PITA hsa-miR-1274a:PITA TOP PITA 4.301E-4 1.352E-2
9.420E-2
2.568E-1
 2 148
20 hsa-miR-7158-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.837E-4 1.444E-2
1.006E-1
2.888E-1
 2 157
21 ATACCTC,MIR-202:MSigDB ATACCTC,MIR-202:MSigDB MSigDB 5.665E-4 1.573E-2
1.097E-1
3.382E-1
 2 170
22 hsa-miR-203b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.798E-4 1.573E-2
1.097E-1
3.462E-1
 2 172
23 hsa-miR-5680:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.990E-4 1.730E-2
1.206E-1
4.173E-1
 2 189
24 hsa-miR-1826:PITA hsa-miR-1826:PITA TOP PITA 7.589E-4 1.730E-2
1.206E-1
4.531E-1
 2 197
25 hsa-miR-6733-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.666E-4 1.730E-2
1.206E-1
4.576E-1
 2 198
26 hsa-miR-3153:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.666E-4 1.730E-2
1.206E-1
4.576E-1
 2 198
27 hsa-miR-6739-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.133E-4 1.730E-2
1.206E-1
4.855E-1
 2 204
28 hsa-miR-220c:PITA hsa-miR-220c:PITA TOP PITA 8.133E-4 1.730E-2
1.206E-1
4.855E-1
 2 204
29 AAAGGGA,MIR-204:MSigDB AAAGGGA,MIR-204:MSigDB MSigDB 8.695E-4 1.730E-2
1.206E-1
5.191E-1
 2 211
30 AAAGGGA,MIR-211:MSigDB AAAGGGA,MIR-211:MSigDB MSigDB 8.695E-4 1.730E-2
1.206E-1
5.191E-1
 2 211
31 hsa-miR-202:PITA hsa-miR-202:PITA TOP PITA 9.614E-4 1.852E-2
1.291E-1
5.740E-1
 2 222
32 hsa-miR-569:PITA hsa-miR-569:PITA TOP PITA 1.140E-3 2.080E-2
1.449E-1
6.807E-1
 2 242
33 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 1.149E-3 2.080E-2
1.449E-1
6.862E-1
 2 243
34 hsa-miR-410-3p:Functional MTI Functional MTI miRTarbase 1.216E-3 2.090E-2
1.457E-1
7.258E-1
 2 250
35 hsa-miR-5186:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.225E-3 2.090E-2
1.457E-1
7.316E-1
 2 251
36 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 1.274E-3 2.113E-2
1.473E-1
7.606E-1
 2 256
37 hsa-miR-1301:PITA hsa-miR-1301:PITA TOP PITA 1.334E-3 2.152E-2
1.500E-1
7.962E-1
 2 262
38 hsa-miR-125a-5p:Functional MTI Functional MTI miRTarbase 1.415E-3 2.223E-2
1.550E-1
8.448E-1
 2 270
39 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 1.552E-3 2.276E-2
1.587E-1
9.268E-1
 2 283
40 hsa-miR-140-5p:PITA hsa-miR-140-5p:PITA TOP PITA 1.552E-3 2.276E-2
1.587E-1
9.268E-1
 2 283
41 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 1.563E-3 2.276E-2
1.587E-1
9.333E-1
 2 284
42 TTGCCAA,MIR-182:MSigDB TTGCCAA,MIR-182:MSigDB MSigDB 1.811E-3 2.574E-2
1.794E-1
1.000E0
 2 306
43 hsa-miR-4278:mirSVR highEffct hsa-miR-4278:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.917E-3 2.623E-2
1.828E-1
1.000E0
 2 315
44 hsa-miR-125a-5p:PITA hsa-miR-125a-5p:PITA TOP PITA 1.977E-3 2.623E-2
1.828E-1
1.000E0
 2 320
45 hsa-miR-125b:PITA hsa-miR-125b:PITA TOP PITA 1.977E-3 2.623E-2
1.828E-1
1.000E0
 2 320
46 hsa-miR-488:PITA hsa-miR-488:PITA TOP PITA 2.050E-3 2.661E-2
1.855E-1
1.000E0
 2 326
47 hsa-miR-1288:mirSVR highEffct hsa-miR-1288:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.253E-3 2.815E-2
1.962E-1
1.000E0
 2 342
48 hsa-miR-519b-3p:Functional MTI Functional MTI miRTarbase 2.279E-3 2.815E-2
1.962E-1
1.000E0
 2 344
49 hsa-miR-519a-3p:Functional MTI Functional MTI miRTarbase 2.344E-3 2.815E-2
1.962E-1
1.000E0
 2 349
50 hsa-miR-519c-3p:Functional MTI Functional MTI miRTarbase 2.357E-3 2.815E-2
1.962E-1
1.000E0
 2 350
Show 45 more annotations

17: Drug [Display Chart] 15 input genes in category / 3015 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000643964 PtdIns(3)P Stitch 1.562E-18 4.708E-15 4.044E-14 4.708E-15 10 175
2 CID000004740 pentoxifylline Stitch 4.056E-10 6.114E-7 5.251E-6 1.223E-6 7 304
3 CID006857352 AC1OAGFW Stitch 9.285E-8 9.331E-5 8.014E-4 2.799E-4 5 185
4 CID005192841 AC1NQAB4 Stitch 4.599E-7 3.467E-4 2.977E-3 1.387E-3 3 24
5 CID000446005 1h6h Stitch 1.207E-6 7.279E-4 6.252E-3 3.640E-3 2 3
6 CID006857413 AC1OAGKW Stitch 6.271E-6 3.151E-3 2.706E-2 1.891E-2 4 193
7 CID000002616 To-day Stitch 8.437E-6 3.180E-3 2.731E-2 2.544E-2 2 7
8 CID000081116 m4-A Stitch 8.437E-6 3.180E-3 2.731E-2 2.544E-2 2 7
9 CID005479139 AC1NUHTW Stitch 1.445E-5 4.842E-3 4.158E-2 4.358E-2 2 9
10 CID003080927 pentamannose phosphate Stitch 3.127E-5 8.570E-3
7.361E-2
9.427E-2
 2 13
11 CID000001675 N3-methylthymidine Stitch 3.127E-5 8.570E-3
7.361E-2
9.427E-2
 2 13
12 CID000151432 androst-5-en-17-one Stitch 3.646E-5 9.162E-3
7.869E-2
1.099E-1
 2 14
13 ctd:C523184 mocetinostat CTD 4.244E-5 9.844E-3
8.454E-2
1.280E-1
 3 106
14 CID000006126 prantal Stitch 4.805E-5 1.035E-2
8.887E-2
1.449E-1
 2 16
15 CID000194695 L-2-amino-6-oxopimelate Stitch 5.443E-5 1.094E-2
9.397E-2
1.641E-1
 2 17
16 CID000001855 DHBT Stitch 6.145E-5 1.123E-2
9.642E-2
1.853E-1
 3 120
17 ctd:C109476 epoxiconazole CTD 6.330E-5 1.123E-2
9.642E-2
1.909E-1
 4 348
18 CID000004274 tetrofosmin Stitch 6.839E-5 1.146E-2
9.839E-2
2.062E-1
 2 19
19 CID000000208 glucose-6-P Stitch 7.698E-5 1.221E-2
1.049E-1
2.321E-1
 4 366
20 CID006398485 AC1O7EKP Stitch 9.228E-5 1.337E-2
1.148E-1
2.782E-1
 2 22
21 CID000000621 NSC82625 Stitch 9.310E-5 1.337E-2
1.148E-1
2.807E-1
 3 138
22 CID000044948 AR39 Stitch 1.102E-4 1.510E-2
1.297E-1
3.322E-1
 2 24
23 1778 DN Berberine chloride [633-65-8]; Down 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP Down 2.470E-4 2.399E-2
2.060E-1
7.446E-1
 3 192
24 CID000001875 6-alpha-methylprednisolone hemisuccinate Stitch 2.503E-4 2.399E-2
2.060E-1
7.548E-1
 2 36
25 1773 DN Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP Down 2.508E-4 2.399E-2
2.060E-1
7.561E-1
 3 193
26 1546 DN Glibenclamide [10238-21-8]; Down 200; 8uM; HL60; HG-U133A Broad Institute CMAP Down 2.508E-4 2.399E-2
2.060E-1
7.561E-1
 3 193
27 5432 DN Fenoterol hydrobromide [1944-12-3]; Down 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.508E-4 2.399E-2
2.060E-1
7.561E-1
 3 193
28 1771 DN Calycanthine [595-05-1]; Down 200; 11.6uM; HL60; HG-U133A Broad Institute CMAP Down 2.624E-4 2.399E-2
2.060E-1
7.911E-1
 3 196
29 1373 DN Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; HL60; HG-U133A Broad Institute CMAP Down 2.624E-4 2.399E-2
2.060E-1
7.911E-1
 3 196
30 2522 DN Napelline [5008-52-6]; Down 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.663E-4 2.399E-2
2.060E-1
8.030E-1
 3 197
31 161 DN (+/-)-verapamil hydrochloride; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 2.663E-4 2.399E-2
2.060E-1
8.030E-1
 3 197
32 2182 DN Bromopride [4093-35-0]; Down 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.703E-4 2.399E-2
2.060E-1
8.151E-1
 3 198
33 4809 DN Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.703E-4 2.399E-2
2.060E-1
8.151E-1
 3 198
34 1615 UP Brinzolamide [138890-62-7]; Up 200; 10.4uM; HL60; HG-U133A Broad Institute CMAP Up 2.744E-4 2.399E-2
2.060E-1
8.272E-1
 3 199
35 1714 UP Artemisinin [63968-64-9]; Up 200; 14.2uM; HL60; HG-U133A Broad Institute CMAP Up 2.784E-4 2.399E-2
2.060E-1
8.395E-1
 3 200
36 CID000040828 DHPN Stitch 2.941E-4 2.463E-2
2.116E-1
8.868E-1
 2 39
37 CID000123854 bis(sulfosuccinimidyl) suberate Stitch 3.095E-4 2.522E-2
2.166E-1
9.331E-1
 2 40
38 CID000753704 sphingosine kinase inhibitor Stitch 3.252E-4 2.580E-2
2.216E-1
9.806E-1
 2 41
39 CID003032542 Randox-T Stitch 3.748E-4 2.897E-2
2.488E-1
1.000E0
 2 44
40 CID001008511 1,4-bis-(phenoxyacetyl)piperazine Stitch 3.983E-4 3.002E-2
2.579E-1
1.000E0
 3 226
41 CID005311143 AC1NSK2T Stitch 4.278E-4 3.146E-2
2.702E-1
1.000E0
 2 47
42 CID000000584 HCCA Stitch 6.073E-4 4.360E-2
3.745E-1
1.000E0
 2 56
43 ctd:D009074 Melanocyte-Stimulating Hormones CTD 6.567E-4 4.500E-2
3.865E-1
1.000E0
 1 1
44 CID000162287 desacetylcephapirin Stitch 6.567E-4 4.500E-2
3.865E-1
1.000E0
 1 1
45 CID004468718 AC1NBIRU Stitch 7.441E-4 4.985E-2
4.282E-1
1.000E0
 2 62
Show 40 more annotations

18: Disease [Display Chart] 13 input genes in category / 214 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3151409 GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-POSITIVE, TYPE III DisGeNET Curated 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
2 C1847902 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder) DisGeNET Curated 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
3 C3809272 LETHAL CONGENITAL CONTRACTURE SYNDROME 5 DisGeNET Curated 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
4 cv:CN178709 Lethal congenital contracture syndrome 5 Clinical Variations 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
5 cv:C3151409 Chronic granulomatous disease, autosomal recessive cytochrome b-positive, type 3 Clinical Variations 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
6 C3280133 PARKINSON DISEASE 17 DisGeNET Curated 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
7 cv:C1847902 DNM2-related intermediate Charcot-Marie-Tooth neuropathy Clinical Variations 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
8 C4025214 Sleepy facial expression DisGeNET Curated 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
9 cv:C3280133 Parkinson disease 17 Clinical Variations 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
10 OMIN:606482 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B; CMTDIB OMIM 8.022E-4 1.717E-2
1.021E-1
1.717E-1
 1 1
11 C0043194 Wiskott-Aldrich Syndrome DisGeNET Curated 1.314E-3 2.555E-2
1.519E-1
2.811E-1
 2 68
12 cv:C1834558 Myopathy, centronuclear, 1 Clinical Variations 1.604E-3 2.640E-2
1.570E-1
3.432E-1
 1 2
13 C1842237 Charcot-Marie-Tooth Disease, Dominant Intermediate C DisGeNET Curated 1.604E-3 2.640E-2
1.570E-1
3.432E-1
 1 2
14 C0334139 Microglial nodules DisGeNET BeFree 2.405E-3 3.027E-2
1.800E-1
5.146E-1
 1 3
15 C1833218 DIABETES MELLITUS, INSULIN-DEPENDENT, 8 DisGeNET Curated 2.405E-3 3.027E-2
1.800E-1
5.146E-1
 1 3
16 C1396126 Perioral eczema DisGeNET Curated 2.405E-3 3.027E-2
1.800E-1
5.146E-1
 1 3
17 C3645536 Autosomal Recessive Centronuclear Myopathy DisGeNET BeFree 2.405E-3 3.027E-2
1.800E-1
5.146E-1
 1 3
18 C3160718 PARKINSON DISEASE, LATE-ONSET DisGeNET Curated 2.758E-3 3.279E-2
1.950E-1
5.903E-1
 2 99
19 C1721006 Keratoderma, Palmoplantar, Epidermolytic DisGeNET Curated 3.205E-3 3.430E-2
2.039E-1
6.859E-1
 1 4
20 C0175778 Larsen syndrome DisGeNET Curated 3.205E-3 3.430E-2
2.039E-1
6.859E-1
 1 4
21 C0410204 Myopathy, Centronuclear, Autosomal Recessive DisGeNET Curated 4.005E-3 4.081E-2
2.427E-1
8.571E-1
 1 5
22 C0339277 Corneal Dystrophy, Juvenile Epithelial of Meesmann DisGeNET Curated 4.804E-3 4.113E-2
2.445E-1
1.000E0
 1 6
23 C0035317 Retinal Hemorrhage DisGeNET Curated 4.804E-3 4.113E-2
2.445E-1
1.000E0
 1 6
24 C0346037 Acral Lentiginous Malignant Melanoma DisGeNET BeFree 4.804E-3 4.113E-2
2.445E-1
1.000E0
 1 6
25 C1833219 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B (disorder) DisGeNET Curated 4.804E-3 4.113E-2
2.445E-1
1.000E0
 1 6
26 C1837496 Axonal degeneration DisGeNET Curated 5.603E-3 4.441E-2
2.640E-1
1.000E0
 1 7
27 C0752282 Congenital Structural Myopathy DisGeNET Curated 5.603E-3 4.441E-2
2.640E-1
1.000E0
 1 7
28 C2932678 Inherited Peripheral Neuropathy DisGeNET Curated 6.401E-3 4.566E-2
2.715E-1
1.000E0
 1 8
29 C1843077 Segmental demyelination/remyelination DisGeNET Curated 6.401E-3 4.566E-2
2.715E-1
1.000E0
 1 8
30 C1834558 Myopathy, Centronuclear, Autosomal Dominant DisGeNET Curated 6.401E-3 4.566E-2
2.715E-1
1.000E0
 1 8
31 cv:C2239176 Hepatocellular carcinoma Clinical Variations 7.199E-3 4.668E-2
2.775E-1
1.000E0
 1 9
32 OMIN:114550 HEPATOCELLULAR CARCINOMA OMIM 7.199E-3 4.668E-2
2.775E-1
1.000E0
 1 9
33 C1861901 Subacute progressive viral hepatitis DisGeNET Curated 7.199E-3 4.668E-2
2.775E-1
1.000E0
 1 9
34 C3542021 Duchenne and Becker Muscular Dystrophy DisGeNET BeFree 7.996E-3 4.753E-2
2.826E-1
1.000E0
 1 10
35 C1842170 Centrally nucleated skeletal muscle fibers DisGeNET Curated 7.996E-3 4.753E-2
2.826E-1
1.000E0
 1 10
36 C4274355 Autosomal dominant late onset Parkinson disease DisGeNET Curated 7.996E-3 4.753E-2
2.826E-1
1.000E0
 1 10
37 C0520743 Mediastinal lymphadenopathy DisGeNET Curated 8.792E-3 4.951E-2
2.944E-1
1.000E0
 1 11
38 C0795953 MASA SYNDROME (disorder) DisGeNET Curated 8.792E-3 4.951E-2
2.944E-1
1.000E0
 1 11
Show 33 more annotations