Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc10_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 44 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0017124 SH3 domain binding 1.414E-9 6.223E-8 2.721E-7 6.223E-8 5 123
2 GO:0043548 phosphatidylinositol 3-kinase binding 1.441E-4 3.169E-3 1.386E-2 6.338E-3 2 38
3 GO:0005070 SH3/SH2 adaptor activity 2.921E-4 4.284E-3 1.873E-2 1.285E-2 2 54
4 GO:0035591 signaling adaptor activity 6.092E-4 6.702E-3 2.930E-2 2.681E-2 2 78
5 GO:0035033 histone deacetylase regulator activity 2.409E-3 1.648E-2
7.207E-2
1.060E-1
 1 5
6 GO:0017034 Rap guanyl-nucleotide exchange factor activity 2.409E-3 1.648E-2
7.207E-2
1.060E-1
 1 5
7 GO:0030674 protein binding, bridging 2.622E-3 1.648E-2
7.207E-2
1.154E-1
 2 163
8 GO:0060090 molecular adaptor activity 3.221E-3 1.771E-2
7.746E-2
1.417E-1
 2 181
9 GO:0016909 SAP kinase activity 4.814E-3 2.117E-2
9.257E-2
2.118E-1
 1 10
10 GO:0004705 JUN kinase activity 4.814E-3 2.117E-2
9.257E-2
2.118E-1
 1 10
11 GO:0008349 MAP kinase kinase kinase kinase activity 5.294E-3 2.117E-2
9.257E-2
2.329E-1
 1 11
12 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5.774E-3 2.117E-2
9.257E-2
2.540E-1
 1 12
13 GO:0001784 phosphotyrosine residue binding 8.650E-3 2.928E-2
1.280E-1
3.806E-1
 1 18
14 GO:0004707 MAP kinase activity 1.008E-2 3.169E-2
1.386E-1
4.437E-1
 1 21
15 GO:0045309 protein phosphorylated amino acid binding 1.343E-2 3.823E-2
1.672E-1
5.908E-1
 1 28
16 GO:0046875 ephrin receptor binding 1.390E-2 3.823E-2
1.672E-1
6.117E-1
 1 29
17 GO:0005158 insulin receptor binding 1.628E-2 4.214E-2
1.843E-1
7.164E-1
 1 34
18 GO:0004674 protein serine/threonine kinase activity 1.883E-2 4.602E-2
2.012E-1
8.284E-1
 2 452
19 GO:0019894 kinesin binding 2.008E-2 4.650E-2
2.033E-1
8.835E-1
 1 42
20 GO:0031593 polyubiquitin modification-dependent protein binding 2.197E-2 4.834E-2
2.114E-1
9.668E-1
 1 46
Show 15 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 315 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007173 epidermal growth factor receptor signaling pathway 2.956E-7 7.986E-5 5.057E-4 9.312E-5 4 132
2 GO:0038127 ERBB signaling pathway 5.071E-7 7.986E-5 5.057E-4 1.597E-4 4 151
3 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 1.172E-6 9.860E-5 6.243E-4 3.693E-4 3 46
4 GO:1901185 negative regulation of ERBB signaling pathway 1.252E-6 9.860E-5 6.243E-4 3.944E-4 3 47
5 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 7.557E-6 4.405E-4 2.789E-3 2.381E-3 3 85
6 GO:1901184 regulation of ERBB signaling pathway 8.390E-6 4.405E-4 2.789E-3 2.643E-3 3 88
7 GO:0038179 neurotrophin signaling pathway 1.155E-4 5.199E-3 3.292E-2 3.640E-2 2 34
8 GO:0048008 platelet-derived growth factor receptor signaling pathway 2.825E-4 1.112E-2
7.042E-2
8.897E-2
 2 53
9 GO:0034352 positive regulation of glial cell apoptotic process 4.833E-4 1.691E-2
1.071E-1
1.522E-1
 1 1
10 GO:0007229 integrin-mediated signaling pathway 9.056E-4 2.853E-2
1.806E-1
2.853E-1
 2 95
11 GO:0075509 endocytosis involved in viral entry into host cell 1.449E-3 3.512E-2
2.223E-1
4.565E-1
 1 3
12 GO:2000017 positive regulation of determination of dorsal identity 1.449E-3 3.512E-2
2.223E-1
4.565E-1
 1 3
13 GO:0019065 receptor-mediated endocytosis of virus by host cell 1.449E-3 3.512E-2
2.223E-1
4.565E-1
 1 3
14 GO:0008286 insulin receptor signaling pathway 1.585E-3 3.566E-2
2.258E-1
4.992E-1
 2 126
15 GO:0007258 JUN phosphorylation 1.932E-3 4.057E-2
2.569E-1
6.085E-1
 1 4
16 GO:2000015 regulation of determination of dorsal identity 2.414E-3 4.753E-2
3.009E-1
7.605E-1
 1 5
Show 11 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 57 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005925 focal adhesion 6.661E-4 1.362E-2
6.304E-2
 3.797E-2 3 393
2 GO:0005924 cell-substrate adherens junction 6.911E-4 1.362E-2
6.304E-2
 3.939E-2 3 398
3 GO:0030055 cell-substrate junction 7.167E-4 1.362E-2
6.304E-2
 4.085E-2 3 403
4 GO:0005912 adherens junction 1.219E-3 1.738E-2
8.043E-2
6.950E-2
 3 484
5 GO:0030027 lamellipodium 3.259E-3 3.716E-2
1.720E-1
1.858E-1
 2 186
6 GO:0016600 flotillin complex 5.183E-3 4.175E-2
1.933E-1
2.954E-1
 1 11
7 GO:0030122 AP-2 adaptor complex 6.123E-3 4.175E-2
1.933E-1
3.490E-1
 1 13
8 GO:0030139 endocytic vesicle 6.500E-3 4.175E-2
1.933E-1
3.705E-1
 2 265
9 GO:0030128 clathrin coat of endocytic vesicle 6.592E-3 4.175E-2
1.933E-1
3.758E-1
 1 14
10 GO:0030132 clathrin coat of coated pit 8.937E-3 4.329E-2
2.004E-1
5.094E-1
 1 19
11 GO:0005769 early endosome 9.022E-3 4.329E-2
2.004E-1
5.142E-1
 2 314
12 GO:0099568 cytoplasmic region 9.640E-3 4.329E-2
2.004E-1
5.495E-1
 2 325
13 GO:0032839 dendrite cytoplasm 9.874E-3 4.329E-2
2.004E-1
5.628E-1
 1 21
14 GO:0030125 clathrin vesicle coat 1.174E-2 4.641E-2
2.148E-1
6.695E-1
 1 25
15 GO:0002102 podosome 1.221E-2 4.641E-2
2.148E-1
6.961E-1
 1 26
16 GO:0031252 cell leading edge 1.360E-2 4.721E-2
2.185E-1
7.753E-1
 2 389
17 GO:0030131 clathrin adaptor complex 1.408E-2 4.721E-2
2.185E-1
8.025E-1
 1 30
Show 12 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 81 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 8 input genes in category / 427 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 9 input genes in category / 93 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR014928 Serine rich InterPro 6.153E-7 2.860E-5 1.463E-4 5.722E-5 2 3
2 PF08824 Serine rich Pfam 6.153E-7 2.860E-5 1.463E-4 5.722E-5 2 3
3 IPR021901 CAS DUF3513 InterPro 1.230E-6 2.860E-5 1.463E-4 1.144E-4 2 4
4 PF12026 DUF3513 Pfam 1.230E-6 2.860E-5 1.463E-4 1.144E-4 2 4
5 PF00018 SH3 1 Pfam 5.322E-5 9.899E-4 5.064E-3 4.950E-3 3 164
6 SM00326 SH3 SMART 1.223E-4 1.500E-3 7.675E-3 1.137E-2 3 217
7 PS50002 SH3 PROSITE 1.223E-4 1.500E-3 7.675E-3 1.137E-2 3 217
8 IPR001452 SH3 domain InterPro 1.291E-4 1.500E-3 7.675E-3 1.200E-2 3 221
9 IPR028848 BCAR1 InterPro 4.804E-4 4.964E-3 2.539E-2 4.468E-2 1 1
10 PF14604 SH3 9 Pfam 6.045E-4 5.622E-3 2.876E-2
5.622E-2
 2 78
11 IPR014742 Adaptor Cbl SH2-like InterPro 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
12 PS51506 CBL PTB PROSITE 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
13 PF02762 Cbl N3 Pfam 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
14 IPR024162 Adaptor Cbl InterPro 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
15 IPR003153 Adaptor Cbl N hlx InterPro 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
16 PF02262 Cbl N Pfam 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
17 IPR014741 Adaptor Cbl EF hand-like InterPro 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
18 1.20.930.20 - Gene3D 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
19 IPR024159 Cbl PTB InterPro 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
20 PF02761 Cbl N2 Pfam 1.441E-3 6.698E-3 3.426E-2
1.340E-1
 1 3
21 IPR021160 MAPKKKK InterPro 1.920E-3 8.504E-3 4.350E-2
1.786E-1
 1 4
22 IPR008351 MAPK JNK InterPro 2.400E-3 1.014E-2
5.189E-2
2.232E-1
 1 5
23 PF12763 EF-hand 4 Pfam 4.795E-3 1.713E-2
8.763E-2
4.459E-1
 1 10
24 IPR000261 EH dom InterPro 5.273E-3 1.713E-2
8.763E-2
4.904E-1
 1 11
25 PS50031 EH PROSITE 5.273E-3 1.713E-2
8.763E-2
4.904E-1
 1 11
26 SM00310 PTBI SMART 5.273E-3 1.713E-2
8.763E-2
4.904E-1
 1 11
27 SM00027 EH SMART 5.273E-3 1.713E-2
8.763E-2
4.904E-1
 1 11
28 PS51064 IRS PTB PROSITE 5.751E-3 1.713E-2
8.763E-2
5.349E-1
 1 12
29 IPR003527 MAP kinase CS InterPro 5.751E-3 1.713E-2
8.763E-2
5.349E-1
 1 12
30 PS01351 MAPK PROSITE 5.751E-3 1.713E-2
8.763E-2
5.349E-1
 1 12
31 1.10.238.10 - Gene3D 6.525E-3 1.713E-2
8.763E-2
6.068E-1
 2 261
32 PF02174 IRS Pfam 6.707E-3 1.713E-2
8.763E-2
6.237E-1
 1 14
33 SM00036 CNH SMART 6.707E-3 1.713E-2
8.763E-2
6.237E-1
 1 14
34 IPR002404 IRS PTB InterPro 6.707E-3 1.713E-2
8.763E-2
6.237E-1
 1 14
35 IPR019804 Ras G-nucl-exch fac CS InterPro 6.707E-3 1.713E-2
8.763E-2
6.237E-1
 1 14
36 PF00780 CNH Pfam 7.184E-3 1.713E-2
8.763E-2
6.681E-1
 1 15
37 PS50219 CNH PROSITE 7.184E-3 1.713E-2
8.763E-2
6.681E-1
 1 15
38 IPR001180 CNH dom InterPro 7.184E-3 1.713E-2
8.763E-2
6.681E-1
 1 15
39 IPR013315 Spectrin alpha SH3 InterPro 7.184E-3 1.713E-2
8.763E-2
6.681E-1
 1 15
40 IPR011992 EF-hand-dom pair InterPro 7.841E-3 1.823E-2
9.326E-2
7.292E-1
 2 287
41 SM00229 RasGEFN SMART 9.569E-3 2.170E-2
1.110E-1
8.899E-1
 1 20
42 PF00618 RasGEF N Pfam 1.005E-2 2.173E-2
1.111E-1
9.342E-1
 1 21
43 SM00726 UIM SMART 1.005E-2 2.173E-2
1.111E-1
9.342E-1
 1 21
44 IPR000651 Ras-like Gua-exchang fac N InterPro 1.052E-2 2.174E-2
1.112E-1
9.785E-1
 1 22
45 PS50212 RASGEF NTER PROSITE 1.052E-2 2.174E-2
1.112E-1
9.785E-1
 1 22
46 PS50330 UIM PROSITE 1.147E-2 2.258E-2
1.155E-1
1.000E0
 1 24
47 IPR008271 Ser/Thr kinase AS InterPro 1.193E-2 2.258E-2
1.155E-1
1.000E0
 2 357
48 IPR003903 UIM dom InterPro 1.195E-2 2.258E-2
1.155E-1
1.000E0
 1 25
49 SM00220 S TKc SMART 1.206E-2 2.258E-2
1.155E-1
1.000E0
 2 359
50 PS00108 PROTEIN KINASE ST PROSITE 1.225E-2 2.258E-2
1.155E-1
1.000E0
 2 362
Show 45 more annotations

7: Pathway [Display Chart] 8 input genes in category / 320 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 137930 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) BioSystems: Pathway Interaction Database 8.391E-13 2.685E-10 1.704E-9 2.685E-10 6 72
2 1457794 Signaling by MET BioSystems: REACTOME 5.948E-8 8.422E-6 5.345E-5 1.903E-5 4 69
3 1470919 InlB-mediated entry of Listeria monocytogenes into host cell BioSystems: REACTOME 7.895E-8 8.422E-6 5.345E-5 2.527E-5 3 15
4 1470917 Listeria monocytogenes entry into host cells BioSystems: REACTOME 1.975E-7 1.474E-5 9.358E-5 6.321E-5 3 20
5 1457805 Negative regulation of MET activity BioSystems: REACTOME 2.304E-7 1.474E-5 9.358E-5 7.372E-5 3 21
6 1269385 EGFR downregulation BioSystems: REACTOME 3.979E-7 2.122E-5 1.347E-4 1.273E-4 3 25
7 137980 Reelin signaling pathway BioSystems: Pathway Interaction Database 6.314E-7 2.886E-5 1.832E-4 2.020E-4 3 29
8 138051 EPO signaling pathway BioSystems: Pathway Interaction Database 9.416E-7 3.304E-5 2.097E-4 3.013E-4 3 33
9 83090 Insulin signaling pathway BioSystems: KEGG 9.774E-7 3.304E-5 2.097E-4 3.128E-4 4 138
10 138013 Internalization of ErbB1 BioSystems: Pathway Interaction Database 1.032E-6 3.304E-5 2.097E-4 3.304E-4 3 34
11 M19358 Signaling of Hepatocyte Growth Factor Receptor MSigDB C2 BIOCARTA (v6.0) 1.339E-6 3.877E-5 2.461E-4 4.286E-4 3 37
12 M3342 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.454E-6 3.877E-5 2.461E-4 4.652E-4 3 38
13 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 3.792E-6 9.335E-5 5.925E-4 1.214E-3 3 52
14 169348 Signaling events mediated by focal adhesion kinase BioSystems: Pathway Interaction Database 4.254E-6 9.723E-5 6.171E-4 1.361E-3 3 54
15 137994 CDC42 signaling events BioSystems: Pathway Interaction Database 9.342E-6 1.993E-4 1.265E-3 2.990E-3 3 70
16 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 2.654E-5 4.993E-4 3.169E-3 8.491E-3 3 99
17 M16973 CBL mediated ligand-induced downregulation of EGF receptors MSigDB C2 BIOCARTA (v6.0) 2.808E-5 4.993E-4 3.169E-3 8.987E-3 2 13
18 138066 JNK signaling in the CD4+ TCR pathway BioSystems: Pathway Interaction Database 2.808E-5 4.993E-4 3.169E-3 8.987E-3 2 13
19 137961 EPHA2 forward signaling BioSystems: Pathway Interaction Database 4.890E-5 8.236E-4 5.228E-3 1.565E-2 2 17
20 1269324 Regulation of signaling by CBL BioSystems: REACTOME 5.500E-5 8.800E-4 5.585E-3 1.760E-2 2 18
21 138021 Paxillin-dependent events mediated by a4b1 BioSystems: Pathway Interaction Database 6.145E-5 9.363E-4 5.943E-3 1.966E-2 2 19
22 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 7.011E-5 1.020E-3 6.473E-3 2.244E-2 3 137
23 137971 Paxillin-independent events mediated by a4b1 and a4b7 BioSystems: Pathway Interaction Database 8.293E-5 1.154E-3 7.323E-3 2.654E-2 2 22
24 P00034 Integrin signalling pathway PantherDB 1.263E-4 1.685E-3 1.069E-2 4.043E-2 3 167
25 M7739 Links between Pyk2 and Map Kinases MSigDB C2 BIOCARTA (v6.0) 1.454E-4 1.861E-3 1.181E-2 4.654E-2 2 29
26 137960 Osteopontin-mediated events BioSystems: Pathway Interaction Database 1.775E-4 2.185E-3 1.387E-2
5.680E-2
 2 32
27 83067 Focal adhesion BioSystems: KEGG 2.123E-4 2.516E-3 1.597E-2
6.795E-2
 3 199
28 137915 Signaling events regulated by Ret tyrosine kinase BioSystems: Pathway Interaction Database 2.511E-4 2.869E-3 1.821E-2
8.035E-2
 2 38
29 138040 IFN-gamma pathway BioSystems: Pathway Interaction Database 2.784E-4 3.072E-3 1.950E-2
8.909E-2
 2 40
30 138026 Insulin Pathway BioSystems: Pathway Interaction Database 3.220E-4 3.435E-3 2.180E-2
1.030E-1
 2 43
31 1269184 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers BioSystems: REACTOME 3.372E-4 3.481E-3 2.209E-2
1.079E-1
 2 44
32 83094 Type II diabetes mellitus BioSystems: KEGG 3.687E-4 3.575E-3 2.269E-2
1.180E-1
 2 46
33 137999 Integrins in angiogenesis BioSystems: Pathway Interaction Database 3.687E-4 3.575E-3 2.269E-2
1.180E-1
 2 46
34 M7955 Genes related to the insulin receptor pathway MSigDB C2 BIOCARTA (v6.0) 4.535E-4 4.265E-3 2.707E-2
1.451E-1
 2 51
35 102279 Endocytosis BioSystems: KEGG 4.665E-4 4.265E-3 2.707E-2
1.493E-1
 3 260
36 137958 Endothelins BioSystems: Pathway Interaction Database 4.898E-4 4.282E-3 2.718E-2
1.567E-1
 2 53
37 169355 RAC1 signaling pathway BioSystems: Pathway Interaction Database 5.085E-4 4.282E-3 2.718E-2
1.627E-1
 2 54
38 138071 PDGFR-beta signaling pathway BioSystems: Pathway Interaction Database 5.085E-4 4.282E-3 2.718E-2
1.627E-1
 2 54
39 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 5.866E-4 4.813E-3 3.055E-2
1.877E-1
 2 58
40 138050 Fc-epsilon receptor I signaling in mast cells BioSystems: Pathway Interaction Database 6.070E-4 4.856E-3 3.082E-2
1.942E-1
 2 59
41 137998 TCR signaling in naive CD4+ T cells BioSystems: Pathway Interaction Database 6.277E-4 4.899E-3 3.110E-2
2.009E-1
 2 60
42 138058 BCR signaling pathway BioSystems: Pathway Interaction Database 7.592E-4 5.785E-3 3.672E-2
2.430E-1
 2 66
43 1383025 Signaling by PTK6 BioSystems: REACTOME 8.058E-4 5.997E-3 3.806E-2
2.579E-1
 2 68
44 83093 Adipocytokine signaling pathway BioSystems: KEGG 8.296E-4 6.033E-3 3.829E-2
2.655E-1
 2 69
45 149807 Bacterial invasion of epithelial cells BioSystems: KEGG 1.006E-3 7.150E-3 4.538E-2
3.218E-1
 2 76
46 M3270 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.169E-3 8.135E-3
5.164E-2
3.742E-1
 2 82
47 1269380 Signaling by EGFR BioSystems: REACTOME 1.274E-3 8.394E-3
5.328E-2
4.077E-1
 3 367
48 PW:0000024 inflammatory response Pathway Ontology 1.285E-3 8.394E-3
5.328E-2
4.111E-1
 1 2
49 83049 ErbB signaling pathway BioSystems: KEGG 1.285E-3 8.394E-3
5.328E-2
4.113E-1
 2 86
50 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.315E-3 8.417E-3
5.343E-2
4.209E-1
 2 87
Show 45 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 3164 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11432831 A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. Pubmed 3.618E-11 5.724E-8 4.944E-7 1.145E-7 3 4
2 9498705 Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. Pubmed 3.618E-11 5.724E-8 4.944E-7 1.145E-7 3 4
3 12618476 CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities. Pubmed 9.045E-11 9.540E-8 8.239E-7 2.862E-7 3 5
4 9820532 Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). Pubmed 1.809E-10 1.431E-7 1.236E-6 5.723E-7 3 6
5 18835194 Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. Pubmed 3.165E-10 2.003E-7 1.730E-6 1.001E-6 3 7
6 11071869 Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes. Pubmed 5.063E-10 2.670E-7 2.306E-6 1.602E-6 3 8
7 8978305 Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation. Pubmed 7.594E-10 3.433E-7 2.965E-6 2.403E-6 3 9
8 15962011 Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. Pubmed 1.491E-9 5.243E-7 4.528E-6 4.719E-6 3 11
9 10464310 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. Pubmed 1.491E-9 5.243E-7 4.528E-6 4.719E-6 3 11
10 20697350 The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Pubmed 2.012E-9 6.365E-7 5.498E-6 6.365E-6 4 78
11 12218189 Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Pubmed 2.584E-9 7.434E-7 6.421E-6 8.177E-6 3 13
12 17474147 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Pubmed 5.722E-9 1.509E-6 1.303E-5 1.810E-5 5 330
13 22974441 SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Pubmed 4.472E-8 8.676E-6 7.494E-5 1.415E-4 3 32
14 10679202 Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl. Pubmed 4.936E-8 8.676E-6 7.494E-5 1.562E-4 2 2
15 15824310 Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. Pubmed 4.936E-8 8.676E-6 7.494E-5 1.562E-4 2 2
16 19417776 CIN85 associates with endosomal membrane and binds phosphatidic acid. Pubmed 4.936E-8 8.676E-6 7.494E-5 1.562E-4 2 2
17 9748234 Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G. Pubmed 4.936E-8 8.676E-6 7.494E-5 1.562E-4 2 2
18 20130058 The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. Pubmed 4.936E-8 8.676E-6 7.494E-5 1.562E-4 2 2
19 10907644 All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
20 22262777 CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
21 12734385 Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
22 21830225 SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
23 11944898 Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
24 17675467 The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
25 15383614 c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
26 21372129 CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
27 10608804 The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
28 12517963 The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
29 12135478 Ruk is ubiquitinated but not degraded by the proteasome. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
30 12130508 Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
31 8683103 Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
32 21765937 NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
33 9497377 T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
34 19268472 Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
35 12874286 Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
36 12671687 Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
37 20711168 A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
38 15465819 Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment. Pubmed 1.481E-7 1.233E-5 1.065E-4 4.685E-4 2 3
39 21725061 CIN85 interacting proteins in B cells-specific role for SHIP-1. Pubmed 1.873E-7 1.520E-5 1.313E-4 5.928E-4 3 51
40 19380743 Charting the molecular network of the drug target Bcr-Abl. Pubmed 2.820E-7 1.703E-5 1.471E-4 8.922E-4 4 266
41 16849543 Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
42 9162067 Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
43 14596919 Dab2 links CIN85 with clathrin-mediated receptor internalization. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
44 8668148 Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
45 25621495 CRK proteins selectively regulate T cell migration into inflamed tissues. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
46 11069064 Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
47 29662228 Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
48 9366405 Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
49 18048363 Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
50 26716506 p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy. Pubmed 2.961E-7 1.703E-5 1.471E-4 9.368E-4 2 4
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 874 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CRK CRK interactions 7.509E-17 6.563E-14 4.824E-13 6.563E-14 9 290
2 int:CRKL CRKL interactions 6.217E-14 2.717E-11 1.997E-10 5.433E-11 7 141
3 int:BCAR1 BCAR1 interactions 7.903E-13 2.302E-10 1.693E-9 6.907E-10 6 84
4 int:ABL1 ABL1 interactions 1.774E-12 3.877E-10 2.850E-9 1.551E-9 7 226
5 int:RAPGEF1 RAPGEF1 interactions 3.878E-10 6.778E-8 4.983E-7 3.389E-7 4 25
6 int:LYN LYN interactions 4.470E-8 6.511E-6 4.786E-5 3.907E-5 5 232
7 int:PIK3R1 PIK3R1 interactions 6.624E-8 8.270E-6 6.079E-5 5.789E-5 5 251
8 int:HCK HCK interactions 8.436E-8 8.758E-6 6.438E-5 7.373E-5 4 92
9 int:CBL CBL interactions 9.710E-8 8.758E-6 6.438E-5 8.487E-5 5 271
10 int:PTK2B PTK2B interactions 1.002E-7 8.758E-6 6.438E-5 8.758E-5 4 96
11 int:PIK3CA PIK3CA interactions 2.464E-7 1.856E-5 1.364E-4 2.154E-4 4 120
12 int:NCK1 NCK1 interactions 2.548E-7 1.856E-5 1.364E-4 2.227E-4 4 121
13 int:PXN PXN interactions 2.904E-7 1.952E-5 1.435E-4 2.538E-4 4 125
14 int:LCK LCK interactions 4.985E-7 3.112E-5 2.287E-4 4.356E-4 4 143
15 int:HRAS HRAS interactions 5.567E-7 3.244E-5 2.385E-4 4.866E-4 4 147
16 int:PTK2 PTK2 interactions 8.629E-7 4.572E-5 3.361E-4 7.542E-4 4 164
17 int:BLNK BLNK interactions 8.893E-7 4.572E-5 3.361E-4 7.772E-4 3 40
18 int:SPRY1 SPRY1 interactions 1.033E-6 5.015E-5 3.686E-4 9.026E-4 3 42
19 int:NEDD9 NEDD9 interactions 1.869E-6 8.598E-5 6.320E-4 1.634E-3 3 51
20 int:PTPN11 PTPN11 interactions 3.266E-6 1.427E-4 1.049E-3 2.855E-3 4 229
21 int:FYN FYN interactions 4.928E-6 2.028E-4 1.490E-3 4.307E-3 4 254
22 int:INPP5D INPP5D interactions 5.104E-6 2.028E-4 1.490E-3 4.461E-3 3 71
23 int:MAPK14 MAPK14 interactions 6.465E-6 2.457E-4 1.806E-3 5.650E-3 4 272
24 int:SHC1 SHC1 interactions 7.048E-6 2.567E-4 1.887E-3 6.160E-3 4 278
25 int:SH2D3A SH2D3A interactions 8.256E-6 2.886E-4 2.122E-3 7.216E-3 2 9
26 int:ID2 ID2 interactions 9.757E-6 3.280E-4 2.411E-3 8.528E-3 3 88
27 int:ITSN2 ITSN2 interactions 1.190E-5 3.852E-4 2.832E-3 1.040E-2 3 94
28 int:SH2D3C SH2D3C interactions 1.512E-5 4.721E-4 3.470E-3 1.322E-2 2 12
29 int:CD2AP CD2AP interactions 1.806E-5 5.443E-4 4.001E-3 1.578E-2 3 108
30 int:TRAF2 TRAF2 interactions 2.064E-5 5.988E-4 4.402E-3 1.804E-2 4 365
31 int:INPPL1 INPPL1 interactions 2.124E-5 5.988E-4 4.402E-3 1.856E-2 3 114
32 int:ITSN1 ITSN1 interactions 2.415E-5 6.597E-4 4.849E-3 2.111E-2 3 119
33 int:LOX LOX interactions 2.747E-5 7.275E-4 5.348E-3 2.401E-2 2 16
34 int:KRT3 KRT3 interactions 5.279E-5 1.357E-3 9.976E-3 4.614E-2 2 22
35 int:KRT79 KRT79 interactions 6.305E-5 1.574E-3 1.157E-2
5.510E-2
 2 24
36 int:FYB1 FYB1 interactions 6.851E-5 1.663E-3 1.223E-2
5.988E-2
 2 25
37 int:TNFRSF1A TNFRSF1A interactions 7.765E-5 1.834E-3 1.348E-2
6.787E-2
 3 176
38 int:TSG101 TSG101 interactions 8.719E-5 1.986E-3 1.460E-2
7.621E-2
 3 183
39 int:CASP3 CASP3 interactions 8.862E-5 1.986E-3 1.460E-2
7.745E-2
 3 184
40 int:ITCH ITCH interactions 1.021E-4 2.231E-3 1.640E-2
8.924E-2
 3 193
41 int:SH3BP2 SH3BP2 interactions 1.131E-4 2.410E-3 1.772E-2
9.881E-2
 2 32
42 int:SYNJ1 SYNJ1 interactions 1.278E-4 2.660E-3 1.955E-2
1.117E-1
 2 34
43 int:MAPK8 MAPK8 interactions 1.368E-4 2.780E-3 2.043E-2
1.195E-1
 3 213
44 int:FRS3 FRS3 interactions 1.516E-4 2.945E-3 2.165E-2
1.325E-1
 2 37
45 int:FGR FGR interactions 1.516E-4 2.945E-3 2.165E-2
1.325E-1
 2 37
46 int:ASAP1 ASAP1 interactions 1.600E-4 3.030E-3 2.227E-2
1.398E-1
 2 38
47 int:SH3KBP1 SH3KBP1 interactions 1.629E-4 3.030E-3 2.227E-2
1.424E-1
 3 226
48 int:BCAR3 BCAR3 interactions 1.686E-4 3.070E-3 2.257E-2
1.474E-1
 2 39
49 int:RAF1 RAF1 interactions 1.738E-4 3.095E-3 2.275E-2
1.519E-1
 3 231
50 int:MAP3K11 MAP3K11 interactions 1.774E-4 3.095E-3 2.275E-2
1.551E-1
 2 40
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13.1-q13.4 19q13.1-q13.4 2.597E-4 2.336E-3 6.610E-3 2.337E-3 1 1
2 6p25-p24 6p25-p24 5.193E-4 2.336E-3 6.610E-3 4.673E-3 1 2
3 Xp22.1-p21.3 Xp22.1-p21.3 7.788E-4 2.336E-3 6.610E-3 7.009E-3 1 3
4 1p32 1p32 6.990E-3 1.319E-2 3.732E-2
6.291E-2
 1 27
5 16q23.1 16q23.1 8.795E-3 1.319E-2 3.732E-2
7.915E-2
 1 34
6 Xq22.3 Xq22.3 8.795E-3 1.319E-2 3.732E-2
7.915E-2
 1 34
7 10q11.22 10q11.22 1.624E-2 2.088E-2
5.908E-2
1.462E-1
 1 63
8 11q23.3 11q23.3 2.135E-2 2.402E-2
6.794E-2
1.921E-1
 1 83
9 9q34.3 9q34.3 2.947E-2 2.947E-2
8.337E-2
2.652E-1
 1 115
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 104 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 469 Cas scaffolding proteins genenames.org 5.436E-7 2.718E-6 6.207E-6 2.718E-6 2 4
2 655 Mitogen-activated protein kinase kinase kinase kinases genenames.org 1.648E-3 4.120E-3 9.407E-3 8.240E-3 1 5
3 651 Mitogen-activated protein kinases genenames.org 4.280E-3 7.133E-3 1.629E-2 2.140E-2 1 13

13: Coexpression [Display Chart] 9 input genes in category / 904 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8182 Genes down-regulated in B lymphocytes immunized with: imiquimod [PubChem=13982876] versus monophosphoryl lipid A and imiquimod [PubChem=13982876]. MSigDB C7: Immunologic Signatures (v6.0) 2.744E-5 1.550E-2
1.145E-1
 2.481E-2 3 162
2 M6477 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 1.550E-2
1.145E-1
 4.650E-2 3 200
3 M6424 Genes up-regulated in monocytes in response to M. tuberculosis 19 kDa lipopeptide: 3h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 1.550E-2
1.145E-1
 4.650E-2 3 200
4 16780769-Table1 Human Leukemia Lin06 37genes GeneSigDB 7.950E-5 1.797E-2
1.327E-1
7.187E-2
 2 35
5 M1666 Strongly down-regulated at 8-96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.529E-4 4.079E-2
3.012E-1
4.998E-1
 2 92
6 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.576E-3 4.079E-2
3.012E-1
1.000E0
 2 156
7 M17811 Genes down-regulated in post-GC, BCL6 [GeneID=604] dependent B cell non-Hodgkin's lymphoma (B-NHL) vs MYC [GeneID=4609] driven pre-GC lymphoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.761E-3 4.079E-2
3.012E-1
1.000E0
 2 165
8 M8234 Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype vs RORC [GeneID=6097] knockout treated with digoxin [PubChem=2724385]. MSigDB C7: Immunologic Signatures (v6.0) 1.889E-3 4.079E-2
3.012E-1
1.000E0
 2 171
9 M8667 Genes down-regulated in monocytes (6h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 4.079E-2
3.012E-1
1.000E0
 2 173
10 M2475 Genes down-regulated in BEAS-2B cells (bronchial epithelium) stimulated with IL13 [GeneID=3596] on days 1 to 3 and then rested for the next 3 days (repeated-stimulation or memory model) MSigDB C2: CGP Curated Gene Sets (v6.0) 1.944E-3 4.079E-2
3.012E-1
1.000E0
 1 5
11 M8898 Genes down-regulated in CD4 [GeneID=920] versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.045E-3 4.079E-2
3.012E-1
1.000E0
 2 178
12 M9717 Genes down-regulated in CD4 [GeneID=920] Th1 cells with EGR2 [GeneID=1959] knockout: control versus anergic. MSigDB C7: Immunologic Signatures (v6.0) 2.398E-3 4.079E-2
3.012E-1
1.000E0
 2 193
13 M9309 Genes down-regulated in CD4: naïve versus FOXP3 [GeneID=50943] knockout T reg precursors. MSigDB C7: Immunologic Signatures (v6.0) 2.447E-3 4.079E-2
3.012E-1
1.000E0
 2 195
14 M6522 Genes up-regulated in epithelial cells (24h): untreated versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 4.079E-2
3.012E-1
1.000E0
 2 196
15 M7571 Genes down-regulated in CD11b BoneMarrow from BALBc mouse versus CD11b BoneMarrow from BALBc mouse incubated with GMCSF and GCSF. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 4.079E-2
3.012E-1
1.000E0
 2 196
16 M6513 Genes down-regulated in epithelial cells (6h): untreated versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 4.079E-2
3.012E-1
1.000E0
 2 196
17 M6524 Genes up-regulated in epithelial cells (24h): untreated versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 4.079E-2
3.012E-1
1.000E0
 2 197
18 M8708 Genes up-regulated in bone marrow-derived macrophages with heterozygous MLL4 [GeneID=9757] knockout: control versus treated with LPS for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 4.079E-2
3.012E-1
1.000E0
 2 197
19 M8355 Genes down-regulated in atherosclerosis macrophages: anti miR-33 versus anti miR. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 4.079E-2
3.012E-1
1.000E0
 2 198
20 M7050 Genes up-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus lymphoid-primed multipotent progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 4.079E-2
3.012E-1
1.000E0
 2 199
21 M3119 Genes down-regulated in comparison of naive T cells versus memory T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 4.079E-2
3.012E-1
1.000E0
 2 199
22 M4981 Genes down-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 0 versus myeloid DCs at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 4.079E-2
3.012E-1
1.000E0
 2 199
23 M6124 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL4 [GeneID=3565] (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
24 M5983 Genes down-regulated in liver with knockouts of: SOCS3 [GeneID=9021] versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
25 M6926 Genes down-regulated in B lymphocytes: control versus anti IgM and cell anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
26 M7205 Genes down-regulated in B lymphocytes: memory versus transitional CR2 [GeneID=1380] high. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
27 M5893 Genes important for mitotic spindle assembly. MSigDB H: Hallmark Gene Sets (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
28 M4567 Genes down-regulated in adult DN2 thymocytes versus adult DN3 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
29 M3354 Genes up-regulated in comparison of dendritic cells (DC) at 4 h after LPS (TLR4 agonist) stimulation versus those at 16 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
30 M4564 Genes down-regulated in comparison of adult thymic progenitors versus adult DN3 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
31 M6617 Genes down-regulated in bone marrow-derived macrophage (180 min): LPS versus IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
32 M7665 Genes up-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes: non-stimulated versus tretinoin [PubChem=444795] and Pam2CSK4 (96h). MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
33 M10032 Genes up-regulated in macrophages: control versus colorectal adenocarcinoma conditioned. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
34 M7831 Genes up-regulated in common dendritic cells versus those cultured and untreated. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
35 M3662 Genes down-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus stimulated naive CD8 T cells from pmel-1 mice. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
36 M7163 Genes up-regulated in CD4 [GeneID=920] T cells: control versus treated with HDAC inhibitors for 12h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
37 M4656 Genes down-regulated in comparison of naive CD8 T cells versus PD-1 high CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
38 M7017 Genes down-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus megakaryo-erythrocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
39 M7448 Genes up-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: TGF beta versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
40 M8081 Genes down-regulated in myeloid-derived suppressor cells with HDC [GeneID=3067] knockout: bone marrow versus colon tumor. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
41 M3225 Genes down-regulated in comparison of regulatory T cell (Treg) versus conventional T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
42 M324 Genes up-regulated in Sez-2 cells (T cell lymphoma): untreated versus IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
43 M7156 Genes up-regulated in CD4 [GeneID=920] T cells: control versus treated with HDAC inhibitors for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
44 M6480 Genes up-regulated in monocyte-derived dendritic cells: untreated versus LPS (3h). MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
45 M6435 Genes up-regulated in NKT cells versus B2 B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
46 M9567 Genes down-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 and BCL2L11 [GeneID=3398;10018] versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
47 M6614 Genes down-regulated in bone marrow-derived macrophages (45 min): IL10 [GeneID=3486] and LPS versus IL6 [GeneID=3469] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
48 M6420 Genes up-regulated in monocytes (24h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
49 M299 Genes up-regulated in primary bronchial epithelial cells stimulated with: IL22 [GeneID=50616] versus IL17A [GeneID=3605]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
50 M6671 Genes down-regulated in bone marrow-derived macrophagesat 180 min of stimulation by IL10 [GeneID=3486] and LPS: IL6 [GeneID=3469] knockout versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 4.079E-2
3.012E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 553 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 6 input genes in category / 22 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 9 input genes in category / 431 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-651:PITA hsa-miR-651:PITA TOP PITA 1.938E-4 2.150E-2
1.429E-1
8.351E-2
 2 169
2 ATACCTC,MIR-202:MSigDB ATACCTC,MIR-202:MSigDB MSigDB 1.960E-4 2.150E-2
1.429E-1
8.450E-2
 2 170
3 hsa-miR-542-3p:TargetScan hsa-miR-542-3p TargetScan 4.499E-4 2.150E-2
1.429E-1
1.939E-1
 2 258
4 hsa-miR-18a-5p:Functional MTI Functional MTI miRTarbase 4.639E-4 2.150E-2
1.429E-1
1.999E-1
 2 262
5 hsa-miR-4685-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.888E-4 2.150E-2
1.429E-1
2.107E-1
 2 269
6 hsa-miR-4287:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.924E-4 2.150E-2
1.429E-1
2.122E-1
 2 270
7 hsa-miR-196b-5p:TargetScan hsa-miR-196b-5p TargetScan 5.181E-4 2.150E-2
1.429E-1
2.233E-1
 2 277
8 hsa-miR-196a-5p:TargetScan hsa-miR-196a-5p TargetScan 5.181E-4 2.150E-2
1.429E-1
2.233E-1
 2 277
9 hsa-miR-5692a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.636E-4 2.150E-2
1.429E-1
2.429E-1
 2 289
10 hsa-miR-4775:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.950E-4 2.150E-2
1.429E-1
2.564E-1
 2 297
11 hsa-miR-203a-3p:Functional MTI Functional MTI miRTarbase 6.395E-4 2.150E-2
1.429E-1
2.756E-1
 2 308
12 hsa-miR-548ah-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.856E-4 2.150E-2
1.429E-1
2.955E-1
 2 319
13 hsa-miR-3609:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.899E-4 2.150E-2
1.429E-1
2.973E-1
 2 320
14 hsa-miR-224-5p:TargetScan hsa-miR-224-5p TargetScan 6.984E-4 2.150E-2
1.429E-1
3.010E-1
 2 322
15 hsa-miR-31-5p:TargetScan hsa-miR-31-5p TargetScan 7.599E-4 2.169E-2
1.441E-1
3.275E-1
 2 336
16 hsa-miR-224:PITA hsa-miR-224:PITA TOP PITA 8.053E-4 2.169E-2
1.441E-1
3.471E-1
 2 346
17 hsa-miR-216a:PITA hsa-miR-216a:PITA TOP PITA 8.856E-4 2.245E-2
1.492E-1
3.817E-1
 2 363
18 hsa-miR-590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.021E-3 2.410E-2
1.601E-1
4.399E-1
 2 390
19 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 1.062E-3 2.410E-2
1.601E-1
4.579E-1
 2 398
20 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 1.193E-3 2.448E-2
1.627E-1
5.141E-1
 2 422
21 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 1.193E-3 2.448E-2
1.627E-1
5.141E-1
 2 422
22 hsa-miR-22-3p:TargetScan hsa-miR-22-3p TargetScan 1.330E-3 2.606E-2
1.732E-1
5.734E-1
 2 446
23 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 1.538E-3 2.882E-2
1.915E-1
6.628E-1
 2 480
24 hsa-miR-3912-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-3 3.353E-2
2.228E-1
8.048E-1
 1 15
Show 19 more annotations

17: Drug [Display Chart] 9 input genes in category / 3491 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000439587 polyproline Stitch 4.196E-8 1.465E-4 1.280E-3 1.465E-4 5 295
2 CID000030956 AC1L1KMJ Stitch 4.527E-7 7.901E-4 6.902E-3 1.580E-3 5 476
3 2391 UP Nortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.881E-5 2.229E-2
1.947E-1
1.704E-1
 3 194
4 3835 DN Dipyrone [5907-38-0]; Down 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.956E-5 2.229E-2
1.947E-1
1.730E-1
 3 195
5 442 DN oligomycin; Down 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Down 5.032E-5 2.229E-2
1.947E-1
1.757E-1
 3 196
6 413 UP trichostatin A; Up 200; 0.1uM; ssMCF7; HG-U133A Broad Institute CMAP Up 5.032E-5 2.229E-2
1.947E-1
1.757E-1
 3 196
7 7310 UP Chenodiol [474-25-9]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.032E-5 2.229E-2
1.947E-1
1.757E-1
 3 196
8 2263 DN Chlorzoxazone [95-25-0]; Down 200; 23.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.109E-5 2.229E-2
1.947E-1
1.783E-1
 3 197
9 CID000329293 NSC311040 Stitch 9.126E-5 3.133E-2
2.737E-1
3.186E-1
 2 37
10 CID000025500 nickel hydroxide Stitch 1.151E-4 3.133E-2
2.737E-1
4.018E-1
 3 259
11 CID005287614 AC1NR9ZF Stitch 1.294E-4 3.133E-2
2.737E-1
4.519E-1
 2 44
12 ctd:C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine CTD 1.811E-4 3.133E-2
2.737E-1
6.324E-1
 2 52
13 CID000001874 AC1L1CFC Stitch 2.255E-4 3.133E-2
2.737E-1
7.874E-1
 2 58
14 CID000002396 GF109203X Stitch 2.614E-4 3.133E-2
2.737E-1
9.126E-1
 3 342
15 CID000078057 3,6,9,12,15-Pentaoxaheptadecane Stitch 3.940E-4 3.133E-2
2.737E-1
1.000E0
 1 1
16 CID000105082 AC1L2Y08 Stitch 5.185E-4 3.133E-2
2.737E-1
1.000E0
 3 432
17 CID000003591 AC1L1G9T Stitch 5.220E-4 3.133E-2
2.737E-1
1.000E0
 3 433
18 ctd:D001285 Atropine CTD 5.795E-4 3.133E-2
2.737E-1
1.000E0
 2 93
19 CID000001101 hex-2-ulose Stitch 5.795E-4 3.133E-2
2.737E-1
1.000E0
 2 93
20 ctd:C009166 retinol acetate CTD 6.046E-4 3.133E-2
2.737E-1
1.000E0
 2 95
21 ctd:C560357 DLJ14 compound CTD 7.879E-4 3.133E-2
2.737E-1
1.000E0
 1 2
22 ctd:C052490 MY 5445 CTD 7.879E-4 3.133E-2
2.737E-1
1.000E0
 1 2
23 CID000005309 IN1076 Stitch 8.388E-4 3.133E-2
2.737E-1
1.000E0
 2 112
24 CID000108042 phenethyl caffeiate Stitch 8.688E-4 3.133E-2
2.737E-1
1.000E0
 2 114
25 CID000123015 AC1L3VO5 Stitch 8.993E-4 3.133E-2
2.737E-1
1.000E0
 2 116
26 CID009549299 EGFR inhibitor Stitch 9.619E-4 3.133E-2
2.737E-1
1.000E0
 2 120
27 ctd:D001149 Arsenates CTD 1.027E-3 3.133E-2
2.737E-1
1.000E0
 2 124
28 CID000444766 1c88 Stitch 1.060E-3 3.133E-2
2.737E-1
1.000E0
 2 126
29 CID000004705 PD153035 Stitch 1.076E-3 3.133E-2
2.737E-1
1.000E0
 2 127
30 CID000098285 tetrahydro-beta-carboline-3-carboxylic acid Stitch 1.110E-3 3.133E-2
2.737E-1
1.000E0
 2 129
31 ctd:D004610 Ellagic Acid CTD 1.179E-3 3.133E-2
2.737E-1
1.000E0
 2 133
32 ctd:C098980 aplidine CTD 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
33 CID000192918 tulipanin Stitch 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
34 ctd:C079836 tyrphostin 25 CTD 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
35 ctd:C515676 CGC 11093 CTD 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
36 CID000107710 N-hydroxy-4-aminoazobenzene Stitch 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
37 CID000028019 potassium metabisulfite Stitch 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
38 CID000342465 benzothiazol-2-ylacetonitrile Stitch 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
39 ctd:C552860 8-bromo-7-methoxychrysin CTD 1.182E-3 3.133E-2
2.737E-1
1.000E0
 1 3
40 ctd:C419708 gefitinib CTD 1.197E-3 3.133E-2
2.737E-1
1.000E0
 2 134
41 CID000115098 trypanothione disulfide Stitch 1.306E-3 3.133E-2
2.737E-1
1.000E0
 2 140
42 CID000214797 Ro 31 Stitch 1.324E-3 3.133E-2
2.737E-1
1.000E0
 2 141
43 CID000004010 AC1L1H7K Stitch 1.380E-3 3.133E-2
2.737E-1
1.000E0
 2 144
44 CID000023990 vanadium Stitch 1.477E-3 3.133E-2
2.737E-1
1.000E0
 2 149
45 CID000174812 CP 205 Stitch 1.575E-3 3.133E-2
2.737E-1
1.000E0
 1 4
46 ctd:C495194 O(2)-(2,4-dinitrophenyl) 1-(4-(N,N-diethylcarboxamido)piperazin-1-yl)diazen-1-ium 1,2-diolate CTD 1.575E-3 3.133E-2
2.737E-1
1.000E0
 1 4
47 CID000115092 NSC 326408 Stitch 1.575E-3 3.133E-2
2.737E-1
1.000E0
 1 4
48 ctd:C117813 apicularen A CTD 1.575E-3 3.133E-2
2.737E-1
1.000E0
 1 4
49 CID000282019 NSC135075 Stitch 1.575E-3 3.133E-2
2.737E-1
1.000E0
 1 4
50 ctd:C508710 L-826266 CTD 1.575E-3 3.133E-2
2.737E-1
1.000E0
 1 4
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 265 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0346429 Multiple malignancy DisGeNET BeFree 9.747E-5 1.464E-2
9.014E-2
 2.583E-2 3 174
2 C3809250 ESTROGEN RESISTANCE DisGeNET Curated 1.105E-4 1.464E-2
9.014E-2
 2.927E-2 2 29
3 C0242621 Isochromosomes DisGeNET BeFree 2.223E-4 1.964E-2
1.210E-1
5.892E-2
 2 41
4 C0598894 Monocytic leukemia DisGeNET BeFree 5.096E-4 2.103E-2
1.295E-1
1.350E-1
 2 62
5 cv:C3150803 Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia Clinical Variations 5.554E-4 2.103E-2
1.295E-1
1.472E-1
 1 1
6 C3696954 Precapillary pulmonary hypertension DisGeNET BeFree 5.554E-4 2.103E-2
1.295E-1
1.472E-1
 1 1
7 C3150803 NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA DisGeNET Curated 5.554E-4 2.103E-2
1.295E-1
1.472E-1
 1 1
8 C0280449 secondary acute myeloid leukemia DisGeNET BeFree 6.493E-4 2.151E-2
1.325E-1
1.721E-1
 2 70
9 C0553580 Ewings sarcoma DisGeNET Curated 7.745E-4 2.264E-2
1.394E-1
2.052E-1
 3 352
10 C0795842 chromosome 11q duplication syndrome DisGeNET BeFree 1.110E-3 2.264E-2
1.394E-1
2.943E-1
 1 2
11 C1262148 Grip strength decreased DisGeNET BeFree 1.110E-3 2.264E-2
1.394E-1
2.943E-1
 1 2
12 OMIN:600651 FRAGILE SITE 11B; FRA11B OMIM 1.110E-3 2.264E-2
1.394E-1
2.943E-1
 1 2
13 OMIN:613563 NOONAN SYNDROME-LIKE DISORDER OMIM 1.110E-3 2.264E-2
1.394E-1
2.943E-1
 1 2
14 C0023470 Myeloid Leukemia DisGeNET Curated 1.944E-3 3.681E-2
2.267E-1
5.153E-1
 3 484
15 C0038604 Subungual exostoses DisGeNET BeFree 2.220E-3 3.922E-2
2.415E-1
5.883E-1
 1 4
16 C1334274 Invasive Carcinoma DisGeNET BeFree 3.092E-3 4.900E-2
3.018E-1
8.193E-1
 2 154
17 C1327920 childhood chronic myelogenous leukemia DisGeNET BeFree 3.328E-3 4.900E-2
3.018E-1
8.820E-1
 1 6
18 OMIN:607785 JUVENILE MYELOMONOCYTIC LEUKEMIA; JMML OMIM 3.328E-3 4.900E-2
3.018E-1
8.820E-1
 1 6
Show 13 more annotations