Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc113_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 29 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008641 ubiquitin-like modifier activating enzyme activity 2.078E-13 6.027E-12 2.388E-11 6.027E-12 4 10
2 GO:0016877 ligase activity, forming carbon-sulfur bonds 9.033E-11 1.310E-9 5.189E-9 2.619E-9 4 40
3 GO:0019781 NEDD8 activating enzyme activity 5.744E-8 5.552E-7 2.200E-6 1.666E-6 2 2
4 GO:0016874 ligase activity 1.185E-6 8.588E-6 3.402E-5 3.435E-5 4 415
5 GO:0071566 UFM1 activating enzyme activity 2.679E-4 1.295E-3 5.130E-3 7.770E-3 1 1
6 GO:0061503 tRNA threonylcarbamoyladenosine dehydratase 2.679E-4 1.295E-3 5.130E-3 7.770E-3 1 1
7 GO:0019948 SUMO activating enzyme activity 5.358E-4 2.220E-3 8.794E-3 1.554E-2 1 2
8 GO:0004839 ubiquitin activating enzyme activity 1.339E-3 4.854E-3 1.923E-2 3.883E-2 1 5
9 GO:0043008 ATP-dependent protein binding 2.677E-3 8.625E-3 3.417E-2
7.763E-2
 1 10
10 GO:0017025 TBP-class protein binding 6.148E-3 1.761E-2
6.978E-2
1.783E-1
 1 23
11 GO:0016922 nuclear receptor binding 6.681E-3 1.761E-2
6.978E-2
1.938E-1
 1 25
12 GO:0016836 hydro-lyase activity 1.756E-2 4.244E-2
1.681E-1
5.093E-1
 1 66
Show 7 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 79 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045116 protein neddylation 4.493E-6 3.549E-4 1.758E-3 3.549E-4 2 13
2 GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process 2.685E-4 1.061E-2
5.253E-2
 2.121E-2 1 1
3 GO:0010265 SCF complex assembly 5.369E-4 1.414E-2
7.003E-2
 4.242E-2 1 2
4 GO:0007113 endomitotic cell cycle 8.053E-4 1.590E-2
7.877E-2
6.362E-2
 1 3
5 GO:1990592 protein K69-linked ufmylation 1.342E-3 1.767E-2
8.751E-2
1.060E-1
 1 5
6 GO:1990564 protein polyufmylation 1.342E-3 1.767E-2
8.751E-2
1.060E-1
 1 5
7 GO:0071569 protein ufmylation 1.610E-3 1.817E-2
9.000E-2
1.272E-1
 1 6
8 GO:0033314 mitotic DNA replication checkpoint 1.878E-3 1.855E-2
9.186E-2
1.484E-1
 1 7
9 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly 3.218E-3 2.825E-2
1.399E-1
2.542E-1
 1 12
10 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly 4.021E-3 3.080E-2
1.526E-1
3.177E-1
 1 15
11 GO:0000076 DNA replication checkpoint 4.289E-3 3.080E-2
1.526E-1
3.388E-1
 1 16
12 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter 5.091E-3 3.235E-2
1.602E-1
4.022E-1
 1 19
13 GO:0051123 RNA polymerase II preinitiation complex assembly 6.428E-3 3.235E-2
1.602E-1
5.078E-1
 1 24
14 GO:0044818 mitotic G2/M transition checkpoint 6.695E-3 3.235E-2
1.602E-1
5.289E-1
 1 25
15 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter 6.695E-3 3.235E-2
1.602E-1
5.289E-1
 1 25
16 GO:2000144 positive regulation of DNA-templated transcription, initiation 6.962E-3 3.235E-2
1.602E-1
5.500E-1
 1 26
17 GO:0070897 transcription preinitiation complex assembly 6.962E-3 3.235E-2
1.602E-1
5.500E-1
 1 26
18 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 8.030E-3 3.322E-2
1.645E-1
6.343E-1
 1 30
19 GO:0033146 regulation of intracellular estrogen receptor signaling pathway 8.563E-3 3.322E-2
1.645E-1
6.765E-1
 1 32
20 GO:1902750 negative regulation of cell cycle G2/M phase transition 8.563E-3 3.322E-2
1.645E-1
6.765E-1
 1 32
21 GO:2000142 regulation of DNA-templated transcription, initiation 8.830E-3 3.322E-2
1.645E-1
6.975E-1
 1 33
22 GO:0030520 intracellular estrogen receptor signaling pathway 1.335E-2 4.795E-2
2.375E-1
1.000E0
 1 50
Show 17 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 3 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031510 SUMO activating enzyme complex 5.246E-4 1.574E-3 2.885E-3 1.574E-3 1 2

4: Human Phenotype [Display Chart] 1 input genes in category / 31 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 84 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 5 input genes in category / 30 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00899 ThiF Pfam 2.046E-13 3.068E-12 1.226E-11 6.137E-12 4 10
2 IPR000594 ThiF NAD FAD-bd InterPro 2.046E-13 3.068E-12 1.226E-11 6.137E-12 4 10
3 3.40.50.720 - Gene3D 3.173E-8 2.615E-7 1.045E-6 9.518E-7 4 169
4 IPR016040 NAD(P)-bd dom InterPro 3.486E-8 2.615E-7 1.045E-6 1.046E-6 4 173
5 IPR000011 UBQ/SUMO-activ enz E1-like InterPro 8.544E-7 5.126E-6 2.048E-5 2.563E-5 2 6
6 IPR014929 E2 binding InterPro 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
7 SM01181 E2 bind SMART 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
8 IPR030468 Uba3 InterPro 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
9 IPR030667 APP-BP1 InterPro 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
10 IPR023318 Ub act enz dom a InterPro 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
11 PF08825 E2 bind Pfam 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
12 3.10.20.260 - Gene3D 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
13 1.10.10.520 - Gene3D 2.669E-4 6.159E-4 2.460E-3 8.006E-3 1 1
14 IPR013932 TATA-bd TIP120 InterPro 5.337E-4 1.067E-3 4.264E-3 1.601E-2 1 2
15 PF08623 TIP120 Pfam 5.337E-4 1.067E-3 4.264E-3 1.601E-2 1 2
16 IPR029752 D-isomer DH CS1 InterPro 8.005E-4 1.413E-3 5.643E-3 2.401E-2 1 3
17 IPR011030 Vitellinogen superhlx InterPro 8.005E-4 1.413E-3 5.643E-3 2.401E-2 1 3
18 IPR033127 UBQ-activ enz E1 Cys AS InterPro 1.067E-3 1.667E-3 6.661E-3 3.202E-2 1 4
19 IPR018074 UBQ-activ enz E1 CS InterPro 1.067E-3 1.667E-3 6.661E-3 3.202E-2 1 4
20 PF10585 UBA e1 thiolCys Pfam 1.334E-3 1.667E-3 6.661E-3 4.001E-2 1 5
21 PS00536 UBIQUITIN ACTIVAT 1 PROSITE 1.334E-3 1.667E-3 6.661E-3 4.001E-2 1 5
22 IPR006140 D-isomer DH NAD-bd InterPro 1.334E-3 1.667E-3 6.661E-3 4.001E-2 1 5
23 PS00865 UBIQUITIN ACTIVAT 2 PROSITE 1.334E-3 1.667E-3 6.661E-3 4.001E-2 1 5
24 IPR019572 UBA E1 Cys InterPro 1.334E-3 1.667E-3 6.661E-3 4.001E-2 1 5
25 PF02985 HEAT Pfam 1.275E-2 1.530E-2
6.110E-2
3.824E-1
 1 48
26 IPR000357 HEAT InterPro 1.539E-2 1.775E-2
7.092E-2
4.616E-1
 1 58
27 PS50077 HEAT REPEAT PROSITE 1.854E-2 2.060E-2
8.232E-2
5.563E-1
 1 70
Show 22 more annotations

7: Pathway [Display Chart] 5 input genes in category / 20 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000435 neddylation Pathway Ontology 5.126E-9 1.025E-7 3.689E-7 1.025E-7 3 11
2 PW:0000415 proteasome degradation involving cullin-dependent ubiquitin ligases Pathway Ontology 7.087E-6 7.087E-5 2.550E-4 1.417E-4 2 11
3 1208955 protein ubiquitylation BioSystems: BIOCYC 5.216E-5 3.478E-4 1.251E-3 1.043E-3 2 29
4 P00060 Ubiquitin proteasome pathway PantherDB 1.269E-4 6.343E-4 2.282E-3 2.537E-3 2 45
5 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 1.176E-3 4.705E-3 1.693E-2 2.353E-2 2 137
6 1268741 SUMO is conjugated to E1 (UBA2:SAE1) BioSystems: REACTOME 2.007E-3 6.689E-3 2.407E-2 4.013E-2 1 5
7 1268742 SUMO is transferred from E1 to E2 (UBE2I, UBC9) BioSystems: REACTOME 2.809E-3 8.024E-3 2.887E-2
5.617E-2
 1 7
8 1268739 Processing and activation of SUMO BioSystems: REACTOME 4.010E-3 1.003E-2 3.607E-2
8.021E-2
 1 10
9 1269193 Antigen processing: Ubiquitination & Proteasome degradation BioSystems: REACTOME 6.029E-3 1.340E-2 4.820E-2
1.206E-1
 2 314
10 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 8.563E-3 1.713E-2
6.161E-2
1.713E-1
 2 376
11 PW:0000015 Alzheimer disease Pathway Ontology 9.603E-3 1.746E-2
6.282E-2
1.921E-1
 1 24
12 138085 Coregulation of Androgen receptor activity BioSystems: Pathway Interaction Database 2.269E-2 3.579E-2
1.287E-1
4.537E-1
 1 57
13 1269331 NIK-->noncanonical NF-kB signaling BioSystems: REACTOME 2.466E-2 3.579E-2
1.287E-1
4.931E-1
 1 62
14 1269306 Dectin-1 mediated noncanonical NF-kB signaling BioSystems: REACTOME 2.505E-2 3.579E-2
1.287E-1
5.010E-1
 1 63
Show 9 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 213 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19250909 E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Pubmed 1.906E-9 2.320E-7 1.378E-6 4.060E-7 3 23
2 16620772 A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Pubmed 2.178E-9 2.320E-7 1.378E-6 4.639E-7 3 24
3 12740388 Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. Pubmed 4.113E-8 1.460E-6 8.675E-6 8.761E-6 2 3
4 14690597 The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Pubmed 4.113E-8 1.460E-6 8.675E-6 8.761E-6 2 3
5 10722740 The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. Pubmed 4.113E-8 1.460E-6 8.675E-6 8.761E-6 2 3
6 12646924 Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. Pubmed 4.113E-8 1.460E-6 8.675E-6 8.761E-6 2 3
7 10207026 Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. Pubmed 8.226E-8 1.752E-6 1.041E-5 1.752E-5 2 4
8 18652489 Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1. Pubmed 8.226E-8 1.752E-6 1.041E-5 1.752E-5 2 4
9 25229838 Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. Pubmed 8.226E-8 1.752E-6 1.041E-5 1.752E-5 2 4
10 17220875 Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Pubmed 8.226E-8 1.752E-6 1.041E-5 1.752E-5 2 4
11 9694792 A new NEDD8-ligating system for cullin-4A. Pubmed 1.371E-7 2.260E-6 1.343E-5 2.920E-5 2 5
12 15361859 A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Pubmed 1.371E-7 2.260E-6 1.343E-5 2.920E-5 2 5
13 28581483 Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Pubmed 1.380E-7 2.260E-6 1.343E-5 2.939E-5 4 495
14 16400609 Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. Pubmed 2.056E-7 2.737E-6 1.626E-5 4.380E-5 2 6
15 27348078 Neddylation requires glycyl-tRNA synthetase to protect activated E2. Pubmed 2.056E-7 2.737E-6 1.626E-5 4.380E-5 2 6
16 19245792 The mechanism of poly-NEDD8 chain formation in vitro. Pubmed 2.056E-7 2.737E-6 1.626E-5 4.380E-5 2 6
17 18264111 Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2. Pubmed 2.879E-7 3.607E-6 2.143E-5 6.131E-5 2 7
18 16503656 Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. Pubmed 6.790E-6 8.035E-5 4.773E-4 1.446E-3 2 32
19 29643511 Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Pubmed 6.092E-5 6.830E-4 4.057E-3 1.298E-2 2 95
20 21151996 Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
21 20368332 Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
22 25842831 [Lentivirus-mediated siRNA targeting sae1 induces cell cycle arrest and apop- tosis in colon cancer cell RKO]. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
23 29499133 Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
24 16328888 Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
25 15208391 Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
26 22821745 E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
27 26929408 Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
28 24691136 Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
29 18442052 UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
30 8954946 Molecular cloning of a novel 120-kDa TBP-interacting protein. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
31 22182960 Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
32 24525735 Suppression of tumor angiogenesis by targeting the protein neddylation pathway. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
33 10581176 Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
34 23185368 A metal-based inhibitor of NEDD8-activating enzyme. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
35 28965491 Compound heterozygous mutations in UBA5 causing early-onset epileptic encephalopathy in two sisters. Pubmed 1.309E-4 7.967E-4 4.733E-3 2.788E-2 1 1
36 22119785 Defining human ERAD networks through an integrative mapping strategy. Pubmed 2.022E-4 9.615E-4 5.712E-3 4.306E-2 2 173
37 12694406 ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
38 21304510 The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
39 16049335 Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
40 27653677 Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
41 22884621 Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
42 25084390 Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
43 11481243 Expression and regulation of the mammalian SUMO-1 E1 enzyme. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
44 19795456 Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
45 15537541 Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
46 28388044 Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
47 28535453 Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
48 20820187 miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
49 27545681 Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
50 14557245 APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. Pubmed 2.618E-4 9.615E-4 5.712E-3
5.577E-2
 1 2
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 864 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NAE1 NAE1 interactions 1.330E-7 1.149E-4 8.436E-4 1.149E-4 3 43
2 int:NSFL1C NSFL1C interactions 1.219E-6 5.268E-4 3.866E-3 1.054E-3 3 89
3 int:UBE2F UBE2F interactions 6.691E-6 1.927E-3 1.414E-2 5.781E-3 2 15
4 int:PCYT2 PCYT2 interactions 1.210E-5 2.614E-3 1.918E-2 1.046E-2 2 20
5 int:ZBTB44 ZBTB44 interactions 2.069E-5 3.574E-3 2.623E-2 1.787E-2 2 26
6 int:CAMK1D CAMK1D interactions 4.468E-5 5.391E-3 3.957E-2 3.861E-2 2 38
7 int:DCPS DCPS interactions 4.709E-5 5.391E-3 3.957E-2 4.069E-2 2 39
8 int:APEH APEH interactions 5.470E-5 5.391E-3 3.957E-2 4.726E-2 2 42
9 int:PAPSS1 PAPSS1 interactions 6.009E-5 5.391E-3 3.957E-2
5.192E-2
 2 44
10 int:UFC1 UFC1 interactions 6.288E-5 5.391E-3 3.957E-2
5.432E-2
 2 45
11 int:UBA3 UBA3 interactions 6.864E-5 5.391E-3 3.957E-2
5.930E-2
 2 47
12 int:NCBP2 NCBP2 interactions 8.092E-5 5.826E-3 4.276E-2
6.992E-2
 2 51
13 int:TP53RK TP53RK interactions 9.421E-5 6.261E-3 4.595E-2
8.140E-2
 2 55
14 int:CAPN2 CAPN2 interactions 1.486E-4 9.170E-3
6.730E-2
1.284E-1
 2 69
15 int:UIMC1 UIMC1 interactions 1.804E-4 1.039E-2
7.625E-2
1.558E-1
 2 76
16 int:AHCY AHCY interactions 2.152E-4 1.162E-2
8.529E-2
1.859E-1
 2 83
17 int:UBA5 UBA5 interactions 2.365E-4 1.188E-2
8.718E-2
2.043E-1
 2 87
18 int:SRP14 SRP14 interactions 2.475E-4 1.188E-2
8.718E-2
2.138E-1
 2 89
19 int:FKBP4 FKBP4 interactions 2.761E-4 1.255E-2
9.214E-2
2.385E-1
 2 94
20 int:USP39 USP39 interactions 3.250E-4 1.404E-2
1.031E-1
2.808E-1
 2 102
21 int:GARS GARS interactions 3.577E-4 1.471E-2
1.080E-1
3.090E-1
 2 107
22 int:PLOD1 PLOD1 interactions 3.988E-4 1.525E-2
1.119E-1
3.446E-1
 2 113
23 int:SND1 SND1 interactions 5.194E-4 1.525E-2
1.119E-1
4.487E-1
 2 129
24 int:EIF4A1 EIF4A1 interactions 5.274E-4 1.525E-2
1.119E-1
4.557E-1
 2 130
25 int:RPS28 RPS28 interactions 5.437E-4 1.525E-2
1.119E-1
4.698E-1
 2 132
26 int:PRDX2 PRDX2 interactions 5.520E-4 1.525E-2
1.119E-1
4.769E-1
 2 133
27 int:TBATA TBATA interactions 5.648E-4 1.525E-2
1.119E-1
4.880E-1
 1 2
28 int:TENM4 TENM4 interactions 5.648E-4 1.525E-2
1.119E-1
4.880E-1
 1 2
29 int:TTC34 TTC34 interactions 5.648E-4 1.525E-2
1.119E-1
4.880E-1
 1 2
30 int:COL19A1 COL19A1 interactions 5.648E-4 1.525E-2
1.119E-1
4.880E-1
 1 2
31 int:RPL39P5 RPL39P5 interactions 5.648E-4 1.525E-2
1.119E-1
4.880E-1
 1 2
32 int:RPL30P8 RPL30P8 interactions 5.648E-4 1.525E-2
1.119E-1
4.880E-1
 1 2
33 int:ALYREF ALYREF interactions 7.583E-4 1.978E-2
1.452E-1
6.551E-1
 2 156
34 int:RPS15AP25 RPS15AP25 interactions 8.471E-4 1.978E-2
1.452E-1
7.319E-1
 1 3
35 int:ADH7 ADH7 interactions 8.471E-4 1.978E-2
1.452E-1
7.319E-1
 1 3
36 int:SLFN12L SLFN12L interactions 8.471E-4 1.978E-2
1.452E-1
7.319E-1
 1 3
37 int:SPATA21 SPATA21 interactions 8.471E-4 1.978E-2
1.452E-1
7.319E-1
 1 3
38 int:DDX17 DDX17 interactions 1.041E-3 2.168E-2
1.591E-1
8.996E-1
 2 183
39 int:HSP90B1 HSP90B1 interactions 1.098E-3 2.168E-2
1.591E-1
9.491E-1
 2 188
40 int:PKD1P1 PKD1P1 interactions 1.129E-3 2.168E-2
1.591E-1
9.758E-1
 1 4
41 int:UNC79 UNC79 interactions 1.129E-3 2.168E-2
1.591E-1
9.758E-1
 1 4
42 int:TMC1 TMC1 interactions 1.129E-3 2.168E-2
1.591E-1
9.758E-1
 1 4
43 int:FRG1BP FRG1BP interactions 1.129E-3 2.168E-2
1.591E-1
9.758E-1
 1 4
44 int:HMGB1P10 HMGB1P10 interactions 1.129E-3 2.168E-2
1.591E-1
9.758E-1
 1 4
45 int:SNORA67 SNORA67 interactions 1.129E-3 2.168E-2
1.591E-1
9.758E-1
 1 4
46 int:YBX3 YBX3 interactions 1.169E-3 2.196E-2
1.612E-1
1.000E0
 2 194
47 int:SNORA7A SNORA7A interactions 1.412E-3 2.391E-2
1.755E-1
1.000E0
 1 5
48 int:ZNF140 ZNF140 interactions 1.412E-3 2.391E-2
1.755E-1
1.000E0
 1 5
49 int:RPL10AP3 RPL10AP3 interactions 1.412E-3 2.391E-2
1.755E-1
1.000E0
 1 5
50 int:SCARA5 SCARA5 interactions 1.412E-3 2.391E-2
1.755E-1
1.000E0
 1 5
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3p24.3-p13 3p24.3-p13 1.443E-4 7.213E-4 1.647E-3 7.213E-4 1 1
2 12q14 12q14 1.586E-3 3.965E-3 9.053E-3 7.929E-3 1 11
3 16q22 16q22 2.594E-3 4.323E-3 9.872E-3 1.297E-2 1 18
4 3q22.1 3q22.1 6.331E-3 7.914E-3 1.807E-2 3.166E-2 1 44
5 19q13.32 19q13.32 1.134E-2 1.134E-2 2.590E-2
5.672E-2
 1 79

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 14 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 100 Ubiquitin like modifier activating enzymes genenames.org 4.601E-14 4.601E-14 4.601E-14 4.601E-14 4 10

13: Coexpression [Display Chart] 5 input genes in category / 400 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7352 Genes up-regulated in HMC-1 (mast leukemia) cells: untreated versus stimulated with T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 6.282E-6 2.513E-3 1.651E-2 2.513E-3 3 200
2 M5684 Genes down-regulated in comparsion of ActCD8 versus ActTreg(see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.436E-2
1.601E-1
2.894E-1
 2 199
3 M8859 Genes down-regulated in lymphoid primed multipotent progenitors versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.436E-2
1.601E-1
2.894E-1
 2 199
4 M5525 Genes down-regulated in comparison of neutrophils versus basophils. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
5 M3078 Genes up-regulated in comparison of healthy CD4 [GeneID=920] T cells versus healthy myeloid cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
6 M3728 Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
7 M3904 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
8 M6993 Genes down-regulated in allogeneic T cells after stimulation with dendritic cells from: liver versus peripheral lymph nodes (pLN). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
9 M6938 Genes down-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
10 M6014 Genes down-regulated in dendritic cells: CIITA [GeneID=4261] knockout versus I ab-/- mice. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
11 M6932 Genes down-regulated in B lymphocytes: anti IgM versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
12 M5843 Genes down-regulated in comparison of virus specific (gp33) exhausted CD8 T cells versus the virus specific (gp276) cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.436E-2
1.601E-1
2.923E-1
 2 200
13 M17026 Genes up-regulated in three-dimentional (3D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.053E-4 2.478E-2
1.628E-1
3.221E-1
 2 210
14 18321301-Table2d Human Stomach Galamb08 6genes GeneSigDB 1.080E-3 3.086E-2
2.028E-1
4.321E-1
 1 5
15 19695104-AF1-2 Human Breast Lin09 15genes GeneSigDB 3.022E-3 4.643E-2
3.050E-1
1.000E0
 1 14
16 M29 Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.230E-3 4.643E-2
3.050E-1
1.000E0
 2 424
17 M3905 Genes down-regulated synergistically in NB4 cells (acute promyelocytic leukemia, APL) by tretinoin and NSC682994 [PubChem=444795;388304]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.238E-3 4.643E-2
3.050E-1
1.000E0
 1 15
18 M15150 Genes up-regulated in cancer stem cells isolated from mammary tumors compared to the non-tumorigenic cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.245E-3 4.643E-2
3.050E-1
1.000E0
 2 425
19 16565969-Table1 Human Thyroid Stolf06 32genes GeneSigDB 5.822E-3 4.643E-2
3.050E-1
1.000E0
 1 27
20 M1500 Strongly down-regulated at 8-48 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.467E-3 4.643E-2
3.050E-1
1.000E0
 1 30
21 16322246-Table1 Mouse StemCell Poonepalli05 35genes GeneSigDB 6.682E-3 4.643E-2
3.050E-1
1.000E0
 1 31
22 M972 Up-regulated at 4 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of methyl methanesulfonate (MMS) MSigDB C2: CGP Curated Gene Sets (v6.0) 7.756E-3 4.643E-2
3.050E-1
1.000E0
 1 36
23 15608061-Table2 Human Breast Zucchi04 50genesup-up-regulated INV MET GeneSigDB 8.615E-3 4.643E-2
3.050E-1
1.000E0
 1 40
24 M14951 The 50 most up-regulated genes in primary invasive breast dutcal carcinoma (IDC) or lymph node metastases, compared to normal mammary epithelium. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.643E-2
3.050E-1
1.000E0
 1 43
25 15592497-Table3 Human Brain Krasnoselsky05 61genes GeneSigDB 9.688E-3 4.643E-2
3.050E-1
1.000E0
 1 45
26 M13714 Down-regulated genes displaying alternative splicing in MDA-MB-435 cells (breast cancer) whose metastatic potential has been reduced by expression of NME1 [GeneID=4830]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.688E-3 4.643E-2
3.050E-1
1.000E0
 1 45
27 M2536 Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.688E-3 4.643E-2
3.050E-1
1.000E0
 1 45
28 M13709 Genes within amplicon 12q13-q21 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.902E-3 4.643E-2
3.050E-1
1.000E0
 1 46
29 M7248 Cluster 3: genes activated by ionizing radiation regardless of ATM [GeneID=472] status. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.033E-2 4.643E-2
3.050E-1
1.000E0
 1 48
30 M11458 Genes that comprise the proteasome gene module MSigDB C2: CGP Curated Gene Sets (v6.0) 1.055E-2 4.643E-2
3.050E-1
1.000E0
 1 49
31 M18789 Genes down-regulated in fibroblasts from old individuals, compared to those from young donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.204E-2 4.643E-2
3.050E-1
1.000E0
 1 56
32 16140955-Table2 Human Leukemia Xu05 61genes GeneSigDB 1.247E-2 4.643E-2
3.050E-1
1.000E0
 1 58
33 11906190-Table2a-2 Human Colon Iizaka02 68genes GeneSigDB 1.247E-2 4.643E-2
3.050E-1
1.000E0
 1 58
34 M1401 Genes whose expression in bone marrow samples correlated inversely with increased levels of serum IL5 [GeneID=3567]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.376E-2 4.643E-2
3.050E-1
1.000E0
 1 64
35 M1576 Selected genes down-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.376E-2 4.643E-2
3.050E-1
1.000E0
 1 64
36 M6698 Up-regulated genes in metastatic vs primary solid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.418E-2 4.643E-2
3.050E-1
1.000E0
 1 66
37 14767473-Table2 Human Pancreas Nakamura04 76genes GeneSigDB 1.440E-2 4.643E-2
3.050E-1
1.000E0
 1 67
38 19695104-AF2 Human Breast Lin09 128genes GeneSigDB 1.482E-2 4.643E-2
3.050E-1
1.000E0
 1 69
39 15947096-TableS1b Mouse BoneMarrow Jacquelin05 82genes GeneSigDB 1.525E-2 4.643E-2
3.050E-1
1.000E0
 1 71
40 20035825-TableS4b Mouse Lung Mikkonen10 103genes GeneSigDB 1.610E-2 4.643E-2
3.050E-1
1.000E0
 1 75
41 17665260-Table2 Human Colon Kim07 95genes GeneSigDB 1.760E-2 4.643E-2
3.050E-1
1.000E0
 1 82
42 19074895-Table3 Human Liver Sakai08 86genes GeneSigDB 1.760E-2 4.643E-2
3.050E-1
1.000E0
 1 82
43 M9224 Selected genes up-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.781E-2 4.643E-2
3.050E-1
1.000E0
 1 83
44 20300634-T2 Human Breast Yoshihara10 88genes GeneSigDB 1.824E-2 4.643E-2
3.050E-1
1.000E0
 1 85
45 12086872-Table12d Human Leukemia Yeoh02 93genes GeneSigDB 1.845E-2 4.643E-2
3.050E-1
1.000E0
 1 86
46 M1167 Selected genes up-regulated during progression through benign to malignant skin tumors formed by treatment with DMBA and TPA [PubChem=6001;4792] chemicals in the two stage skin carcinogenesis model. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.887E-2 4.643E-2
3.050E-1
1.000E0
 1 88
47 17488685-SuppTable1 Human Leukemia Chiaretti07 108genes GeneSigDB 2.164E-2 4.643E-2
3.050E-1
1.000E0
 1 101
48 18304324-GeneList Human Breast Xu08 112genes GeneSigDB 2.312E-2 4.643E-2
3.050E-1
1.000E0
 1 108
49 M15305 Genes constituting the BRCA-centered network (BCN). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.503E-2 4.643E-2
3.050E-1
1.000E0
 1 117
50 16707426-SuppTable2 Human Prostate Zhang06 128genes GeneSigDB 2.609E-2 4.643E-2
3.050E-1
1.000E0
 1 122
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 124 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor Top 200 Genes 3.692E-5 2.202E-3 1.189E-2 4.578E-3 3 341
2 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype Noncycling AT1 Precursor E16.5 Top 200 Genes 3.692E-5 2.202E-3 1.189E-2 4.578E-3 3 341
3 gudmap developingKidney e15.5 Ureteral Smooth Musc 500 k2 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.328E-5 2.202E-3 1.189E-2 6.606E-3 2 51
4 gudmap developingKidney e15.5 Peripheral blastema 1000 k5 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.284E-4 3.981E-3 2.150E-2 1.592E-2 2 79
5 gudmap developingKidney e15.5 Ureteral Smooth Musc 1000 k1 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.115E-4 7.724E-3 4.172E-2 3.862E-2 2 123
6 gudmap developingKidney e15.5 1000 k1 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.148E-4 8.573E-3 4.631E-2
5.144E-2
 2 142
7 Cap mesenchyme (CM) Cap mesenchyme (CM) 7.721E-4 1.368E-2
7.387E-2
9.574E-2
 2 194
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla Wilms Nephrogenesis/Kidney Normal-Medulla Wilms F1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla Wilms Nephrogenesis/Kidney Normal-Medulla Wilms F1 Adult, Development, and Cancer types 1.831E-3 2.838E-2
1.533E-1
2.271E-1
 1 8
9 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2a Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2a Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 2.237E-3 3.083E-2
1.665E-1
2.774E-1
 2 332
10 10X Human 68K PBMC CD8+/CD45RA+ Naive Cytotoxic Subtype CD8+/CD45RA+ Naive Cytotoxic-CD8+/CD45RA+ Naive Cytotoxic c10 Top 200 Genes 10X Human 68K PBMC CD8+/CD45RA+ Naive Cytotoxic Subtype CD8+/CD45RA+ Naive Cytotoxic-CD8+/CD45RA+ Naive Cytotoxic c10 Top 200 Genes 2.755E-3 3.139E-2
1.696E-1
3.417E-1
 2 369
11 10X Human 8K PBMC T cell Subtype T cell-CD8B RP11-291B21.2 S100B Top 200 Genes 10X Human 8K PBMC T cell Subtype T cell-CD8B RP11-291B21.2 S100B Top 200 Genes 2.785E-3 3.139E-2
1.696E-1
3.453E-1
 2 371
12 gudmap developingKidney e15.5 Ureteral Smooth Musc 500 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.119E-3 3.223E-2
1.741E-1
3.867E-1
 2 393
Show 7 more annotations

15: Computational [Display Chart] 3 input genes in category / 47 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2731 GCM RAB10 Neighborhood of RAB10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.067E-4 4.261E-2
1.891E-1
 4.261E-2 2 176

16: MicroRNA [Display Chart] 5 input genes in category / 209 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4266:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.671E-5 3.492E-3 2.068E-2 3.492E-3 2 94
2 hsa-miR-382-3p:TargetScan hsa-miR-382-3p TargetScan 7.137E-5 7.458E-3 4.416E-2 1.492E-2 2 194
3 hsa-miR-371a-5p:TargetScan hsa-miR-371a-5p TargetScan 1.433E-4 8.667E-3
5.132E-2
 2.995E-2 2 275
4 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 2.279E-4 8.667E-3
5.132E-2
 4.763E-2 2 347
5 hsa-miR-30d-5p:Functional MTI Functional MTI miRTarbase 2.562E-4 8.667E-3
5.132E-2
5.354E-2
 2 368
6 hsa-miR-4323:mirSVR highEffct hsa-miR-4323:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.255E-4 8.667E-3
5.132E-2
6.802E-2
 2 415
7 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 3.270E-4 8.667E-3
5.132E-2
6.835E-2
 2 416
8 hsa-miR-205-5p:TargetScan hsa-miR-205-5p TargetScan 3.317E-4 8.667E-3
5.132E-2
6.934E-2
 2 419
9 hsa-miR-933:PITA hsa-miR-933:PITA TOP PITA 1.245E-3 2.830E-2
1.676E-1
2.603E-1
 1 18
10 hsa-miR-6816-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.420E-3 2.830E-2
1.676E-1
5.058E-1
 1 35
11 hsa-miR-3651:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.558E-3 2.830E-2
1.676E-1
5.347E-1
 1 37
12 hsa-miR-154-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.696E-3 2.830E-2
1.676E-1
5.636E-1
 1 39
13 hsa-miR-136-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.830E-2
1.676E-1
6.934E-1
 1 48
14 hsa-miR-3670:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.830E-2
1.676E-1
6.934E-1
 1 48
15 hsa-miR-6759-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.525E-3 2.830E-2
1.676E-1
7.367E-1
 1 51
16 hsa-miR-487a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.732E-3 2.830E-2
1.676E-1
7.800E-1
 1 54
17 hsa-miR-3663-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 2.830E-2
1.676E-1
8.088E-1
 1 56
18 hsa-miR-7976:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.830E-2
1.676E-1
8.665E-1
 1 60
19 hsa-miR-6779-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.830E-2
1.676E-1
8.665E-1
 1 60
20 hsa-miR-556-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.830E-2
1.676E-1
8.665E-1
 1 60
21 hsa-miR-103b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.215E-3 2.830E-2
1.676E-1
8.809E-1
 1 61
22 hsa-miR-3181:mirSVR highEffct hsa-miR-3181:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.284E-3 2.830E-2
1.676E-1
8.953E-1
 1 62
23 hsa-miR-1273g-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.284E-3 2.830E-2
1.676E-1
8.953E-1
 1 62
24 hsa-miR-299-5p:Functional MTI Functional MTI miRTarbase 4.353E-3 2.830E-2
1.676E-1
9.098E-1
 1 63
25 hsa-miR-4312:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.353E-3 2.830E-2
1.676E-1
9.098E-1
 1 63
26 hsa-miR-4687-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.830E-2
1.676E-1
9.242E-1
 1 64
27 hsa-miR-651-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.491E-3 2.830E-2
1.676E-1
9.386E-1
 1 65
28 hsa-miR-2116-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.830E-2
1.676E-1
9.530E-1
 1 66
29 hsa-miR-129-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.629E-3 2.830E-2
1.676E-1
9.674E-1
 1 67
30 hsa-miR-539-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.629E-3 2.830E-2
1.676E-1
9.674E-1
 1 67
31 hsa-miR-346:PITA hsa-miR-346:PITA TOP PITA 4.836E-3 2.830E-2
1.676E-1
1.000E0
 1 70
32 hsa-miR-129-2-3p:Functional MTI Functional MTI miRTarbase 4.905E-3 2.830E-2
1.676E-1
1.000E0
 1 71
33 hsa-miR-203a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.830E-2
1.676E-1
1.000E0
 1 74
34 hsa-miR-7844-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.830E-2
1.676E-1
1.000E0
 1 75
35 hsa-miR-374a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.830E-2
1.676E-1
1.000E0
 1 75
36 hsa-miR-7156-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.456E-3 2.830E-2
1.676E-1
1.000E0
 1 79
37 hsa-miR-4273:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.525E-3 2.830E-2
1.676E-1
1.000E0
 1 80
38 hsa-miR-3975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.525E-3 2.830E-2
1.676E-1
1.000E0
 1 80
39 hsa-miR-151a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 5.525E-3 2.830E-2
1.676E-1
1.000E0
 1 80
40 hsa-miR-4700-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.594E-3 2.830E-2
1.676E-1
1.000E0
 1 81
41 hsa-miR-6739-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.663E-3 2.830E-2
1.676E-1
1.000E0
 1 82
42 hsa-miR-22-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.007E-3 2.830E-2
1.676E-1
1.000E0
 1 87
43 hsa-miR-4477b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.214E-3 2.830E-2
1.676E-1
1.000E0
 1 90
44 hsa-miR-4677-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.283E-3 2.830E-2
1.676E-1
1.000E0
 1 91
45 hsa-miR-6830-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.420E-3 2.830E-2
1.676E-1
1.000E0
 1 93
46 hsa-miR-299-3p:TargetScan hsa-miR-299-3p TargetScan 6.489E-3 2.830E-2
1.676E-1
1.000E0
 1 94
47 hsa-miR-181c*:mirSVR highEffct hsa-miR-181c*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.627E-3 2.830E-2
1.676E-1
1.000E0
 1 96
48 hsa-miR-933:mirSVR highEffct hsa-miR-933:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.696E-3 2.830E-2
1.676E-1
1.000E0
 1 97
49 hsa-miR-548v:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.109E-3 2.830E-2
1.676E-1
1.000E0
 1 103
50 hsa-miR-511-5p:Functional MTI Functional MTI miRTarbase 7.246E-3 2.830E-2
1.676E-1
1.000E0
 1 105
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 194 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000801 auxin Stitch 4.469E-8 8.669E-6 5.069E-5 8.669E-6 4 224
2 CID000001132 thiamine pyrophosphate Stitch 1.745E-6 1.693E-4 9.901E-4 3.386E-4 3 129
3 CID005512209 S)-sirtinol Stitch 2.145E-5 1.373E-3 8.031E-3 4.161E-3 2 34
4 CID000003239 NSC325611 Stitch 2.832E-5 1.373E-3 8.031E-3 5.493E-3 2 39
5 CID000012536 Apolar Stitch 1.844E-4 7.155E-3 4.184E-2 3.577E-2 2 99
6 CID000105087 (+/-)-Jasmonic Acid Stitch 4.690E-4 1.188E-2
6.948E-2
9.099E-2
 2 158
7 CID000006466 gibberellin (GA Stitch 5.175E-4 1.188E-2
6.948E-2
1.004E-1
 2 166
8 CID000164453 Chromosaponin I Stitch 6.566E-4 1.188E-2
6.948E-2
1.274E-1
 1 3
9 1998 DN Niclosamide [50-65-7]; Down 200; 12.2uM; HL60; HG-U133A Broad Institute CMAP Down 6.630E-4 1.188E-2
6.948E-2
1.286E-1
 2 188
10 CID006420160 2f34 Stitch 6.630E-4 1.188E-2
6.948E-2
1.286E-1
 2 188
11 424 UP LY294002; Up 200; 0.1uM; MCF7; HG-U133A Broad Institute CMAP Up 7.203E-4 1.188E-2
6.948E-2
1.397E-1
 2 196
12 1435 UP Aztreonam [78110-38-0]; Up 200; 9.2uM; HL60; HG-U133A Broad Institute CMAP Up 7.349E-4 1.188E-2
6.948E-2
1.426E-1
 2 198
13 CID000030583 NSC148832 Stitch 1.041E-3 1.529E-2
8.943E-2
2.020E-1
 2 236
14 CID000081462 BT-B Stitch 1.104E-3 1.529E-2
8.943E-2
2.141E-1
 2 243
15 CID000003744 indole-3-propionic acid Stitch 2.843E-3 3.677E-2
2.150E-1
5.515E-1
 1 13
16 CID000117909 BIPM Stitch 3.934E-3 4.739E-2
2.771E-1
7.633E-1
 1 18
17 CID005289420 AC1NRD9S Stitch 4.153E-3 4.739E-2
2.771E-1
8.056E-1
 1 19
18 CID000000800 indole-3-acetaldehyde Stitch 6.115E-3 4.825E-2
2.821E-1
1.000E0
 1 28
19 CID003001978 B5-9 Stitch 6.986E-3 4.825E-2
2.821E-1
1.000E0
 1 32
20 DB00171 Adenosine triphosphate Drug Bank 7.204E-3 4.825E-2
2.821E-1
1.000E0
 1 33
21 ctd:C539933 ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulphamate CTD 7.204E-3 4.825E-2
2.821E-1
1.000E0
 1 33
22 CID000104406 E1-P Stitch 7.204E-3 4.825E-2
2.821E-1
1.000E0
 1 33
23 CID006432003 tricarbon Stitch 8.509E-3 4.825E-2
2.821E-1
1.000E0
 1 39
24 CID006432277 CID6432277 Stitch 8.944E-3 4.825E-2
2.821E-1
1.000E0
 1 41
25 CID000444966 Cu L Stitch 8.944E-3 4.825E-2
2.821E-1
1.000E0
 1 41
26 ctd:D013876 Thiophenes CTD 1.003E-2 4.825E-2
2.821E-1
1.000E0
 1 46
27 CID000444451 AC1L9GCG Stitch 1.003E-2 4.825E-2
2.821E-1
1.000E0
 1 46
28 ctd:D000068180 Aripiprazole CTD 1.025E-2 4.825E-2
2.821E-1
1.000E0
 1 47
29 CID000024470 silver nitrate Stitch 1.068E-2 4.825E-2
2.821E-1
1.000E0
 1 49
30 ctd:C117342 calfactant CTD 1.068E-2 4.825E-2
2.821E-1
1.000E0
 1 49
31 CID000024014 CuCl2 Stitch 1.177E-2 4.825E-2
2.821E-1
1.000E0
 1 54
32 CID000001794 hexamethylene amiloride Stitch 1.220E-2 4.825E-2
2.821E-1
1.000E0
 1 56
33 ctd:D009153 Mutagens CTD 1.328E-2 4.825E-2
2.821E-1
1.000E0
 1 61
34 CID000061605 Rubidium chromate Stitch 1.610E-2 4.825E-2
2.821E-1
1.000E0
 1 74
35 CID006437867 D dB Stitch 1.674E-2 4.825E-2
2.821E-1
1.000E0
 1 77
36 CID000160615 4-hydroxytestosterone Stitch 1.696E-2 4.825E-2
2.821E-1
1.000E0
 1 78
37 CID000006862 naphthalene acetic acid Stitch 1.696E-2 4.825E-2
2.821E-1
1.000E0
 1 78
38 CID000073271 uracil-4-acetic acid Stitch 2.019E-2 4.825E-2
2.821E-1
1.000E0
 1 93
39 CID000000186 acetyl phosphate Stitch 2.127E-2 4.825E-2
2.821E-1
1.000E0
 1 98
40 ctd:C553817 7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one CTD 2.321E-2 4.825E-2
2.821E-1
1.000E0
 1 107
41 CID000003830 cytokinin Stitch 2.385E-2 4.825E-2
2.821E-1
1.000E0
 1 110
42 CID000000535 1-aminocyclopropane-1-carboxylic acid Stitch 2.471E-2 4.825E-2
2.821E-1
1.000E0
 1 114
43 CID000000624 ST013873 Stitch 2.792E-2 4.825E-2
2.821E-1
1.000E0
 1 129
44 CID000001486 2,4-dichlorophenoxyacetic acid Stitch 2.857E-2 4.825E-2
2.821E-1
1.000E0
 1 132
45 CID000006325 ethylene Stitch 3.070E-2 4.825E-2
2.821E-1
1.000E0
 1 142
46 CID000003220 emodin Stitch 3.070E-2 4.825E-2
2.821E-1
1.000E0
 1 142
47 ctd:C017803 zinc protoporphyrin CTD 3.198E-2 4.825E-2
2.821E-1
1.000E0
 1 148
48 ctd:D005395 Fish Oils CTD 3.241E-2 4.825E-2
2.821E-1
1.000E0
 1 150
49 ctd:D002273 Carcinogens CTD 3.305E-2 4.825E-2
2.821E-1
1.000E0
 1 153
50 ctd:C080703 SK&F 83959 CTD 3.326E-2 4.825E-2
2.821E-1
1.000E0
 1 154
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 6 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0013080 Down Syndrome DisGeNET Curated 6.511E-3 3.907E-2
9.571E-2
 3.907E-2 2 425