Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc119_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 39 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005201 extracellular matrix structural constituent 5.818E-8 2.269E-6 9.652E-6 2.269E-6 4 78
2 GO:0048407 platelet-derived growth factor binding 1.701E-5 3.317E-4 1.411E-3 6.634E-4 2 12
3 GO:0004720 protein-lysine 6-oxidase activity 2.142E-3 1.566E-2
6.659E-2
8.354E-2
 1 4
4 GO:0019838 growth factor binding 2.486E-3 1.566E-2
6.659E-2
9.695E-2
 2 142
5 GO:0004565 beta-galactosidase activity 2.677E-3 1.566E-2
6.659E-2
1.044E-1
 1 5
6 GO:0016997 alpha-sialidase activity 3.211E-3 1.566E-2
6.659E-2
1.252E-1
 1 6
7 GO:0004308 exo-alpha-sialidase activity 3.211E-3 1.566E-2
6.659E-2
1.252E-1
 1 6
8 GO:0016936 galactoside binding 3.211E-3 1.566E-2
6.659E-2
1.252E-1
 1 6
9 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 8.011E-3 3.471E-2
1.477E-1
3.124E-1
 1 15
10 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1.014E-2 3.954E-2
1.682E-1
3.954E-1
 1 19
11 GO:0005540 hyaluronic acid binding 1.279E-2 4.501E-2
1.915E-1
4.988E-1
 1 24
12 GO:0015925 galactosidase activity 1.385E-2 4.501E-2
1.915E-1
5.401E-1
 1 26
Show 7 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 271 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030198 extracellular matrix organization 6.862E-13 9.511E-11 5.879E-10 1.860E-10 8 354
2 GO:0043062 extracellular structure organization 7.019E-13 9.511E-11 5.879E-10 1.902E-10 8 355
3 GO:0030199 collagen fibril organization 1.361E-6 1.229E-4 7.597E-4 3.687E-4 3 43
4 GO:0030574 collagen catabolic process 5.246E-6 3.554E-4 2.197E-3 1.422E-3 3 67
5 GO:0032963 collagen metabolic process 3.183E-5 1.725E-3 1.066E-2 8.626E-3 3 122
6 GO:0085029 extracellular matrix assembly 9.737E-5 4.398E-3 2.718E-2 2.639E-2 2 28
7 GO:0071560 cellular response to transforming growth factor beta stimulus 2.093E-4 7.365E-3 4.553E-2
5.671E-2
 3 230
8 GO:0071559 response to transforming growth factor beta 2.174E-4 7.365E-3 4.553E-2
5.892E-2
 3 233
9 GO:0035904 aorta development 3.659E-4 1.102E-2
6.810E-2
9.915E-2
 2 54
10 GO:0071230 cellular response to amino acid stimulus 5.301E-4 1.268E-2
7.839E-2
1.437E-1
 2 65
11 GO:1902618 cellular response to fluoride 5.370E-4 1.268E-2
7.839E-2
1.455E-1
 1 1
12 GO:0031589 cell-substrate adhesion 5.616E-4 1.268E-2
7.839E-2
1.522E-1
 3 322
13 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 6.751E-4 1.407E-2
8.699E-2
1.830E-1
 3 343
14 GO:0007422 peripheral nervous system development 8.020E-4 1.552E-2
9.595E-2
2.173E-1
 2 80
15 GO:0060840 artery development 1.013E-3 1.793E-2
1.108E-1
2.747E-1
 2 90
16 GO:0022617 extracellular matrix disassembly 1.059E-3 1.793E-2
1.108E-1
2.869E-1
 2 92
17 GO:0007229 integrin-mediated signaling pathway 1.128E-3 1.799E-2
1.112E-1
3.058E-1
 2 95
18 GO:0060414 aorta smooth muscle tissue morphogenesis 1.610E-3 2.182E-2
1.349E-1
4.363E-1
 1 3
19 GO:0044691 tooth eruption 1.610E-3 2.182E-2
1.349E-1
4.363E-1
 1 3
20 GO:0071306 cellular response to vitamin E 1.610E-3 2.182E-2
1.349E-1
4.363E-1
 1 3
21 GO:0043200 response to amino acid 2.066E-3 2.644E-2
1.634E-1
5.599E-1
 2 129
22 GO:1902617 response to fluoride 2.146E-3 2.644E-2
1.634E-1
5.817E-1
 1 4
23 GO:0008065 establishment of blood-nerve barrier 2.682E-3 3.160E-2
1.953E-1
7.269E-1
 1 5
24 GO:0036072 direct ossification 3.218E-3 3.488E-2
2.156E-1
8.721E-1
 1 6
25 GO:0001957 intramembranous ossification 3.218E-3 3.488E-2
2.156E-1
8.721E-1
 1 6
26 GO:0030168 platelet activation 3.471E-3 3.618E-2
2.237E-1
9.407E-1
 2 168
27 GO:0048251 elastic fiber assembly 3.753E-3 3.633E-2
2.245E-1
1.000E0
 1 7
28 GO:0019388 galactose catabolic process 3.753E-3 3.633E-2
2.245E-1
1.000E0
 1 7
29 GO:0007179 transforming growth factor beta receptor signaling pathway 4.147E-3 3.874E-2
2.395E-1
1.000E0
 2 184
30 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway 4.289E-3 3.874E-2
2.395E-1
1.000E0
 1 8
31 GO:0051216 cartilage development 4.738E-3 4.142E-2
2.560E-1
1.000E0
 2 197
32 GO:0007160 cell-matrix adhesion 5.169E-3 4.149E-2
2.564E-1
1.000E0
 2 206
33 GO:0071229 cellular response to acid chemical 5.169E-3 4.149E-2
2.564E-1
1.000E0
 2 206
34 GO:0032224 positive regulation of synaptic transmission, cholinergic 5.358E-3 4.149E-2
2.564E-1
1.000E0
 1 10
35 GO:0038065 collagen-activated signaling pathway 5.358E-3 4.149E-2
2.564E-1
1.000E0
 1 10
36 GO:2001223 negative regulation of neuron migration 5.892E-3 4.202E-2
2.597E-1
1.000E0
 1 11
37 GO:0060346 bone trabecula formation 5.892E-3 4.202E-2
2.597E-1
1.000E0
 1 11
38 GO:0043589 skin morphogenesis 5.892E-3 4.202E-2
2.597E-1
1.000E0
 1 11
39 GO:0042340 keratan sulfate catabolic process 6.427E-3 4.374E-2
2.704E-1
1.000E0
 1 12
40 GO:0048705 skeletal system morphogenesis 6.456E-3 4.374E-2
2.704E-1
1.000E0
 2 231
41 GO:0009612 response to mechanical stimulus 6.730E-3 4.448E-2
2.749E-1
1.000E0
 2 236
42 GO:0006012 galactose metabolic process 6.960E-3 4.491E-2
2.776E-1
1.000E0
 1 13
43 GO:0061430 bone trabecula morphogenesis 8.027E-3 4.834E-2
2.988E-1
1.000E0
 1 15
44 GO:0032222 regulation of synaptic transmission, cholinergic 8.027E-3 4.834E-2
2.988E-1
1.000E0
 1 15
45 GO:0033197 response to vitamin E 8.027E-3 4.834E-2
2.988E-1
1.000E0
 1 15
46 GO:0061448 connective tissue development 8.480E-3 4.936E-2
3.051E-1
1.000E0
 2 266
47 GO:0035025 positive regulation of Rho protein signal transduction 8.560E-3 4.936E-2
3.051E-1
1.000E0
 1 16
Show 42 more annotations

3: GO: Cellular Component [Display Chart] 10 input genes in category / 55 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 3.518E-12 1.935E-10 8.889E-10 1.935E-10 8 444
2 GO:0044420 extracellular matrix component 5.046E-9 1.388E-7 6.374E-7 2.775E-7 5 141
3 GO:0005581 collagen trimer 8.719E-8 1.599E-6 7.343E-6 4.796E-6 4 88
4 GO:0098644 complex of collagen trimers 1.831E-7 2.518E-6 1.157E-5 1.007E-5 3 23
5 GO:0098643 banded collagen fibril 1.630E-5 1.495E-4 6.865E-4 8.967E-4 2 12
6 GO:0005583 fibrillar collagen trimer 1.630E-5 1.495E-4 6.865E-4 8.967E-4 2 12
7 GO:0005788 endoplasmic reticulum lumen 1.432E-4 1.125E-3 5.168E-3 7.876E-3 3 207
8 GO:0005586 collagen type III trimer 5.246E-4 2.623E-3 1.205E-2 2.885E-2 1 1
9 GO:0098648 collagen anchoring fibril 5.246E-4 2.623E-3 1.205E-2 2.885E-2 1 1
10 GO:0098652 collagen type VII anchoring fibril 5.246E-4 2.623E-3 1.205E-2 2.885E-2 1 1
11 GO:0005590 collagen type VII trimer 5.246E-4 2.623E-3 1.205E-2 2.885E-2 1 1
12 GO:0005584 collagen type I trimer 1.049E-3 4.808E-3 2.209E-2
5.770E-2
 1 2
13 GO:0005604 basement membrane 1.415E-3 5.987E-3 2.750E-2
7.783E-2
 2 109
14 GO:0030934 anchoring collagen complex 1.573E-3 6.180E-3 2.839E-2
8.652E-2
 1 3
15 GO:0071953 elastic fiber 2.097E-3 7.689E-3 3.532E-2
1.153E-1
 1 4
16 GO:0031258 lamellipodium membrane 9.926E-3 3.412E-2
1.567E-1
5.459E-1
 1 19
17 GO:0031941 filamentous actin 1.408E-2 4.555E-2
2.092E-1
7.743E-1
 1 27
Show 12 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 1106 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002620 Systemic artery abnormality 7.051E-7 5.922E-4 4.493E-3 7.799E-4 7 471
2 HP:0000766 Abnormality of the sternum 1.511E-6 5.922E-4 4.493E-3 1.671E-3 6 297
3 HP:0001382 Joint hypermobility 1.701E-6 5.922E-4 4.493E-3 1.882E-3 6 303
4 HP:0011061 Abnormality of dental structure 2.142E-6 5.922E-4 4.493E-3 2.369E-3 6 315
5 HP:0000015 Bladder diverticulum 3.626E-6 6.696E-4 5.080E-3 4.010E-3 3 20
6 HP:3000050 Abnormality of odontoid tissue 3.632E-6 6.696E-4 5.080E-3 4.018E-3 5 177
7 HP:0004299 Hernia of the abdominal wall 5.286E-6 8.352E-4 6.336E-3 5.846E-3 6 367
8 HP:0010866 Abdominal wall defect 7.449E-6 9.154E-4 6.945E-3 8.239E-3 6 389
9 HP:0100656 Thoracoabdominal wall defect 7.449E-6 9.154E-4 6.945E-3 8.239E-3 6 389
10 HP:0100790 Hernia 1.236E-5 1.288E-3 9.771E-3 1.367E-2 6 424
11 HP:0001075 Atrophic scars 1.281E-5 1.288E-3 9.771E-3 1.417E-2 3 30
12 HP:0004298 Abnormality of the abdominal wall 1.398E-5 1.289E-3 9.776E-3 1.546E-2 6 433
13 HP:0000023 Inguinal hernia 1.567E-5 1.333E-3 1.011E-2 1.733E-2 5 238
14 HP:0001030 Fragile skin 2.242E-5 1.771E-3 1.344E-2 2.480E-2 3 36
15 HP:0001724 Aortic dilatation 5.956E-5 4.392E-3 3.331E-2
6.587E-2
 4 148
16 HP:0001073 Cigarette-paper scars 7.043E-5 4.605E-3 3.494E-2
7.789E-2
 2 8
17 HP:0004414 Abnormality of the pulmonary artery 7.385E-5 4.605E-3 3.494E-2
8.168E-2
 5 327
18 HP:0000939 Osteoporosis 7.495E-5 4.605E-3 3.494E-2
8.290E-2
 5 328
19 HP:0000670 Carious teeth 8.916E-5 4.786E-3 3.631E-2
9.861E-2
 4 164
20 HP:0000993 Molluscoid pseudotumors 9.047E-5 4.786E-3 3.631E-2
1.001E-1
 2 9
21 HP:0002979 Bowing of the legs 9.131E-5 4.786E-3 3.631E-2
1.010E-1
 4 165
22 HP:0002647 Aortic dissection 9.519E-5 4.786E-3 3.631E-2
1.053E-1
 3 58
23 HP:0001633 Abnormal mitral valve morphology 1.003E-4 4.823E-3 3.659E-2
1.109E-1
 4 169
24 HP:0005111 Dilatation of the ascending aorta 1.163E-4 5.360E-3 4.066E-2
1.286E-1
 3 62
25 HP:0002808 Kyphosis 1.506E-4 6.664E-3
5.055E-2
1.666E-1
 5 379
26 HP:0005897 Severe generalized osteoporosis 1.654E-4 7.038E-3
5.339E-2
1.830E-1
 2 12
27 HP:0005758 Basilar impression 1.954E-4 7.096E-3
5.383E-2
2.161E-1
 2 13
28 HP:0000592 Blue sclerae 1.974E-4 7.096E-3
5.383E-2
2.184E-1
 3 74
29 HP:0003170 Abnormality of the acetabulum 2.055E-4 7.096E-3
5.383E-2
2.273E-1
 3 75
30 HP:0004930 Abnormality of the pulmonary vasculature 2.197E-4 7.096E-3
5.383E-2
2.430E-1
 5 410
31 HP:0004942 Aortic aneurysm 2.223E-4 7.096E-3
5.383E-2
2.458E-1
 3 77
32 HP:0000963 Thin skin 2.223E-4 7.096E-3
5.383E-2
2.458E-1
 3 77
33 HP:0006487 Bowing of the long bones 2.255E-4 7.096E-3
5.383E-2
2.494E-1
 4 208
34 HP:0003023 Bowing of limbs due to multiple fractures 2.277E-4 7.096E-3
5.383E-2
2.519E-1
 2 14
35 HP:0003061 Gracile long bones 2.310E-4 7.096E-3
5.383E-2
2.554E-1
 3 78
36 HP:0003100 Slender long bone 2.310E-4 7.096E-3
5.383E-2
2.554E-1
 3 78
37 HP:0006504 Anomaly of the limb diaphyses 2.384E-4 7.125E-3
5.405E-2
2.636E-1
 4 211
38 HP:0001537 Umbilical hernia 2.564E-4 7.462E-3
5.661E-2
2.836E-1
 4 215
39 HP:0001551 Abnormality of the umbilicus 2.754E-4 7.809E-3
5.924E-2
3.046E-1
 4 219
40 HP:0001462 Abnormality of external features of the abdomen 2.903E-4 8.026E-3
6.088E-2
3.210E-1
 4 222
41 HP:0005474 Decreased calvarial ossification 2.998E-4 8.087E-3
6.135E-2
3.316E-1
 2 16
42 HP:0001634 Mitral valve prolapse 3.087E-4 8.129E-3
6.167E-2
3.414E-1
 3 86
43 HP:0001654 Abnormal heart valve morphology 3.250E-4 8.162E-3
6.192E-2
3.594E-1
 5 445
44 HP:0000212 Gingival overgrowth 3.305E-4 8.162E-3
6.192E-2
3.655E-1
 3 88
45 HP:0000940 Abnormal diaphysis morphology 3.329E-4 8.162E-3
6.192E-2
3.681E-1
 4 230
46 HP:0005855 Multiple prenatal fractures 3.395E-4 8.162E-3
6.192E-2
3.754E-1
 2 17
47 HP:0002981 Abnormality of the calf 3.558E-4 8.372E-3
6.351E-2
3.935E-1
 4 234
48 HP:0003179 Protrusio acetabuli 3.816E-4 8.786E-3
6.665E-2
4.220E-1
 2 18
49 HP:0004334 Dermal atrophy 3.892E-4 8.786E-3
6.665E-2
4.305E-1
 3 93
50 HP:0000926 Platyspondyly 4.017E-4 8.887E-3
6.741E-2
4.443E-1
 3 94
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 984 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008438 abnormal cutaneous collagen fibril morphology 1.314E-6 5.381E-4 4.019E-3 1.293E-3 3 27
2 MP:0009862 abnormal aorta elastic tissue morphology 1.314E-6 5.381E-4 4.019E-3 1.293E-3 3 27
3 MP:0006083 abnormal blood vessel elastic tissue morphology 1.640E-6 5.381E-4 4.019E-3 1.614E-3 3 29
4 MP:0005503 abnormal tendon morphology 4.761E-6 1.171E-3 8.748E-3 4.685E-3 3 41
5 MP:0030798 joint contracture 6.706E-6 1.263E-3 9.433E-3 6.599E-3 2 5
6 MP:0009873 abnormal aorta tunica media morphology 7.701E-6 1.263E-3 9.433E-3 7.578E-3 3 48
7 MP:0009866 abnormal aorta wall morphology 1.516E-5 2.050E-3 1.531E-2 1.491E-2 3 60
8 MP:0030484 abnormal osteocyte lacuna morphology 1.875E-5 2.050E-3 1.531E-2 1.845E-2 2 8
9 MP:0004675 rib fractures 1.875E-5 2.050E-3 1.531E-2 1.845E-2 2 8
10 MP:0000160 kyphosis 2.832E-5 2.787E-3 2.082E-2 2.787E-2 4 232
11 MP:0009420 skeletal muscle endomysial fibrosis 3.679E-5 3.205E-3 2.394E-2 3.620E-2 2 11
12 MP:0011643 abnormal tendon collagen fibril morphology 4.412E-5 3.205E-3 2.394E-2 4.342E-2 2 12
13 MP:0013624 decreased femur compact bone thickness 4.412E-5 3.205E-3 2.394E-2 4.342E-2 2 12
14 MP:0000272 abnormal aorta morphology 4.775E-5 3.205E-3 2.394E-2 4.698E-2 4 265
15 MP:0004044 aortic dissection 5.212E-5 3.205E-3 2.394E-2
5.129E-2
 2 13
16 MP:0013622 abnormal femur compact bone thickness 5.212E-5 3.205E-3 2.394E-2
5.129E-2
 2 13
17 MP:0000135 decreased compact bone thickness 6.230E-5 3.606E-3 2.693E-2
6.130E-2
 3 96
18 MP:0009865 abnormal aorta smooth muscle morphology 7.010E-5 3.674E-3 2.744E-2
6.898E-2
 2 15
19 MP:0000074 abnormal neurocranium morphology 7.263E-5 3.674E-3 2.744E-2
7.147E-2
 4 295
20 MP:0010876 decreased bone volume 7.467E-5 3.674E-3 2.744E-2
7.347E-2
 3 102
21 MP:0008069 abnormal joint mobility 1.020E-4 4.478E-3 3.345E-2
1.004E-1
 2 18
22 MP:0008753 abnormal osteocyte morphology 1.020E-4 4.478E-3 3.345E-2
1.004E-1
 2 18
23 MP:0004174 abnormal spine curvature 1.047E-4 4.478E-3 3.345E-2
1.030E-1
 4 324
24 MP:0030485 abnormal osteocyte lacunocanalicular system morphology 1.140E-4 4.672E-3 3.490E-2
1.121E-1
 2 19
25 MP:0011655 abnormal systemic artery morphology 1.206E-4 4.746E-3 3.545E-2
1.186E-1
 4 336
26 MP:0013630 increased bone trabecular spacing 1.266E-4 4.790E-3 3.578E-2
1.245E-1
 2 20
27 MP:0000134 abnormal compact bone thickness 1.468E-4 5.349E-3 3.996E-2
1.444E-1
 3 128
28 MP:0003109 short femur 1.537E-4 5.394E-3 4.029E-2
1.512E-1
 3 130
29 MP:0001243 abnormal dermal layer morphology 1.608E-4 5.394E-3 4.029E-2
1.582E-1
 3 132
30 MP:0030825 decreased femur size 1.644E-4 5.394E-3 4.029E-2
1.618E-1
 3 133
31 MP:0003089 decreased skin tensile strength 1.994E-4 6.329E-3 4.727E-2
1.962E-1
 2 25
32 MP:0009414 skeletal muscle fiber necrosis 2.159E-4 6.438E-3 4.809E-2
2.124E-1
 2 26
33 MP:0001245 thick dermal layer 2.159E-4 6.438E-3 4.809E-2
2.124E-1
 2 26
34 MP:0005275 abnormal skin tensile strength 2.693E-4 7.481E-3
5.588E-2
2.650E-1
 2 29
35 MP:0013629 abnormal bone trabecular spacing 2.693E-4 7.481E-3
5.588E-2
2.650E-1
 2 29
36 MP:0000753 paralysis 2.737E-4 7.481E-3
5.588E-2
2.693E-1
 3 158
37 MP:0005150 cachexia 2.893E-4 7.694E-3
5.747E-2
2.847E-1
 3 161
38 MP:0000069 kyphoscoliosis 3.286E-4 8.509E-3
6.356E-2
3.234E-1
 2 32
39 MP:0010874 abnormal bone volume 3.455E-4 8.717E-3
6.511E-2
3.400E-1
 3 171
40 MP:0000061 fragile skeleton 3.713E-4 9.135E-3
6.823E-2
3.654E-1
 2 34
41 MP:0006397 disorganized long bone epiphyseal plate 3.937E-4 9.223E-3
6.889E-2
3.874E-1
 2 35
42 MP:0004991 decreased bone strength 3.937E-4 9.223E-3
6.889E-2
3.874E-1
 2 35
43 MP:0003797 abnormal compact bone morphology 4.217E-4 9.650E-3
7.208E-2
4.150E-1
 3 183
44 MP:0020039 increased bone ossification 5.411E-4 1.196E-2
8.937E-2
5.324E-1
 2 41
45 MP:0000559 abnormal femur morphology 5.472E-4 1.196E-2
8.937E-2
5.384E-1
 3 200
46 MP:0009419 skeletal muscle fibrosis 5.679E-4 1.203E-2
8.984E-2
5.588E-1
 2 42
47 MP:0003856 abnormal hindlimb stylopod morphology 5.798E-4 1.203E-2
8.984E-2
5.705E-1
 3 204
48 MP:0000161 scoliosis 5.953E-4 1.203E-2
8.984E-2
5.858E-1
 2 43
49 MP:0000920 abnormal myelination 6.051E-4 1.203E-2
8.984E-2
5.954E-1
 3 207
50 MP:0004992 increased bone resorption 6.234E-4 1.203E-2
8.984E-2
6.134E-1
 2 44
Show 45 more annotations

6: Domain [Display Chart] 10 input genes in category / 130 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR008160 Collagen InterPro 1.057E-5 2.612E-4 1.423E-3 1.374E-3 3 85
2 PF01391 Collagen Pfam 1.057E-5 2.612E-4 1.423E-3 1.374E-3 3 85
3 SM00038 COLFI SMART 1.407E-5 2.612E-4 1.423E-3 1.829E-3 2 11
4 PD002078 Fib collagen C ProDom 1.407E-5 2.612E-4 1.423E-3 1.829E-3 2 11
5 PS51461 NC1 FIB PROSITE 1.407E-5 2.612E-4 1.423E-3 1.829E-3 2 11
6 IPR000885 Fib collagen C InterPro 1.407E-5 2.612E-4 1.423E-3 1.829E-3 2 11
7 PF01410 COLFI Pfam 1.407E-5 2.612E-4 1.423E-3 1.829E-3 2 11
8 PF00093 VWC Pfam 9.621E-5 1.563E-3 8.519E-3 1.251E-2 2 28
9 PS01208 VWFC 1 PROSITE 1.600E-4 2.109E-3 1.149E-2 2.080E-2 2 36
10 PS50184 VWFC 2 PROSITE 1.784E-4 2.109E-3 1.149E-2 2.320E-2 2 38
11 SM00214 VWC SMART 1.784E-4 2.109E-3 1.149E-2 2.320E-2 2 38
12 IPR001007 VWF dom InterPro 2.183E-4 2.365E-3 1.288E-2 2.838E-2 2 42
13 PF13364 BetaGal dom4 5 Pfam 5.338E-4 4.626E-3 2.520E-2
6.939E-2
 1 1
14 IPR025300 BetaGal jelly roll dom InterPro 5.338E-4 4.626E-3 2.520E-2
6.939E-2
 1 1
15 IPR003979 Tropoelastin InterPro 5.338E-4 4.626E-3 2.520E-2
6.939E-2
 1 1
16 2.60.120.260 - Gene3D 6.604E-4 5.366E-3 2.924E-2
8.585E-2
 2 73
17 IPR019801 Glyco hydro 35 CS InterPro 1.067E-3 7.886E-3 4.297E-2
1.387E-1
 1 2
18 IPR008979 Galactose-bd-like InterPro 1.092E-3 7.886E-3 4.297E-2
1.419E-1
 2 94
19 IPR015446 BMP 1/tolloid-like InterPro 1.601E-3 1.083E-2
5.902E-2
2.081E-1
 1 3
20 IPR031330 Gly Hdrlase 35 cat InterPro 2.134E-3 1.083E-2
5.902E-2
2.774E-1
 1 4
21 IPR001944 Glycoside Hdrlase 35 InterPro 2.134E-3 1.083E-2
5.902E-2
2.774E-1
 1 4
22 IPR026283 B-gal 1-like InterPro 2.134E-3 1.083E-2
5.902E-2
2.774E-1
 1 4
23 PS01182 GLYCOSYL HYDROL F35 PROSITE 2.134E-3 1.083E-2
5.902E-2
2.774E-1
 1 4
24 PF01301 Glyco hydro 35 Pfam 2.134E-3 1.083E-2
5.902E-2
2.774E-1
 1 4
25 IPR009254 Laminin aI InterPro 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
26 IPR019828 Lysyl oxidase CS InterPro 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
27 PS00926 LYSYL OXIDASE PROSITE 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
28 IPR001695 Lysyl oxidase InterPro 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
29 PF06008 Laminin I Pfam 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
30 IPR010307 Laminin domII InterPro 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
31 PF01186 Lysyl oxidase Pfam 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
32 PF06009 Laminin II Pfam 2.666E-3 1.083E-2
5.902E-2
3.466E-1
 1 5
33 PF01400 Astacin Pfam 3.199E-3 1.223E-2
6.664E-2
4.158E-1
 1 6
34 IPR001506 Peptidase M12A InterPro 3.199E-3 1.223E-2
6.664E-2
4.158E-1
 1 6
35 PF00052 Laminin B Pfam 4.263E-3 1.458E-2
7.946E-2
5.542E-1
 1 8
36 IPR000034 Laminin IV InterPro 4.263E-3 1.458E-2
7.946E-2
5.542E-1
 1 8
37 SM00281 LamB SMART 4.263E-3 1.458E-2
7.946E-2
5.542E-1
 1 8
38 PS51115 LAMININ IVA PROSITE 4.263E-3 1.458E-2
7.946E-2
5.542E-1
 1 8
39 PF00054 Laminin G 1 Pfam 5.857E-3 1.952E-2
1.064E-1
7.614E-1
 1 11
40 SM00181 EGF SMART 6.652E-3 1.999E-2
1.089E-1
8.648E-1
 2 236
41 IPR000538 Link dom InterPro 6.919E-3 1.999E-2
1.089E-1
8.995E-1
 1 13
42 PF00193 Xlink Pfam 6.919E-3 1.999E-2
1.089E-1
8.995E-1
 1 13
43 PS50963 LINK 2 PROSITE 6.919E-3 1.999E-2
1.089E-1
8.995E-1
 1 13
44 SM00445 LINK SMART 6.919E-3 1.999E-2
1.089E-1
8.995E-1
 1 13
45 PS01241 LINK 1 PROSITE 6.919E-3 1.999E-2
1.089E-1
8.995E-1
 1 13
46 IPR000742 EGF-like dom InterPro 7.437E-3 2.087E-2
1.137E-1
9.668E-1
 2 250
47 PS00022 EGF 1 PROSITE 7.785E-3 2.087E-2
1.137E-1
1.000E0
 2 256
48 IPR013032 EGF-like CS InterPro 8.141E-3 2.087E-2
1.137E-1
1.000E0
 2 262
49 PS01186 EGF 2 PROSITE 8.383E-3 2.087E-2
1.137E-1
1.000E0
 2 266
50 IPR008211 Laminin N InterPro 8.509E-3 2.087E-2
1.137E-1
1.000E0
 1 16
Show 45 more annotations

7: Pathway [Display Chart] 10 input genes in category / 81 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270244 Extracellular matrix organization BioSystems: REACTOME 4.737E-10 2.197E-8 1.094E-7 3.837E-8 7 298
2 1270247 Assembly of collagen fibrils and other multimeric structures BioSystems: REACTOME 5.425E-10 2.197E-8 1.094E-7 4.394E-8 5 60
3 1270245 Collagen formation BioSystems: REACTOME 5.105E-9 1.378E-7 6.862E-7 4.135E-7 5 93
4 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v6.0) 2.145E-8 4.343E-7 2.162E-6 1.737E-6 6 275
5 1270246 Collagen biosynthesis and modifying enzymes BioSystems: REACTOME 1.876E-7 3.039E-6 1.513E-5 1.519E-5 4 70
6 172847 Protein digestion and absorption BioSystems: KEGG 5.187E-7 7.003E-6 3.486E-5 4.202E-5 4 90
7 M3005 Genes encoding collagen proteins MSigDB C2 BIOCARTA (v6.0) 4.858E-6 5.543E-5 2.759E-4 3.935E-4 3 44
8 1470926 Collagen chain trimerization BioSystems: REACTOME 5.940E-6 5.543E-5 2.759E-4 4.811E-4 3 47
9 P00034 Integrin signalling pathway PantherDB 6.159E-6 5.543E-5 2.759E-4 4.988E-4 4 167
10 1270248 Anchoring fibril formation BioSystems: REACTOME 2.084E-5 1.535E-4 7.640E-4 1.688E-3 2 9
11 1270249 Crosslinking of collagen fibrils BioSystems: REACTOME 2.084E-5 1.535E-4 7.640E-4 1.688E-3 2 9
12 167324 Amoebiasis BioSystems: KEGG 5.127E-5 3.460E-4 1.723E-3 4.153E-3 3 96
13 1269899 Scavenging by Class A Receptors BioSystems: REACTOME 1.210E-4 7.536E-4 3.751E-3 9.797E-3 2 21
14 1270251 Elastic fibre formation BioSystems: REACTOME 4.915E-4 2.844E-3 1.415E-2 3.981E-2 2 42
15 1269897 Binding and Uptake of Ligands by Scavenger Receptors BioSystems: REACTOME 6.693E-4 3.614E-3 1.799E-2
5.421E-2
 2 49
16 142400 lactose degradation III BioSystems: BIOCYC 8.032E-4 4.066E-3 2.024E-2
6.506E-2
 1 1
17 83068 ECM-receptor interaction BioSystems: KEGG 1.863E-3 8.879E-3 4.420E-2
1.509E-1
 2 82
18 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 2.702E-3 1.216E-2
6.053E-2
2.189E-1
 2 99
19 PW:0000021 hypertension Pathway Ontology 3.209E-3 1.368E-2
6.811E-2
2.600E-1
 1 4
20 413378 Keratan sulfate degradation BioSystems: KEGG 4.010E-3 1.596E-2
7.942E-2
3.248E-1
 1 5
21 952858 Platelet activation BioSystems: KEGG 4.137E-3 1.596E-2
7.942E-2
3.351E-1
 2 123
22 MAP00531 Glycosaminoglycan degradation MAP00531 Glycosaminoglycan degradation GenMAPP 8.006E-3 2.948E-2
1.467E-1
6.485E-1
 1 10
23 MAP00600 Sphingoglycolipid metabolism MAP00600 Sphingoglycolipid metabolism GenMAPP 9.600E-3 3.154E-2
1.570E-1
7.776E-1
 1 12
24 1269979 Keratan sulfate degradation BioSystems: REACTOME 9.600E-3 3.154E-2
1.570E-1
7.776E-1
 1 12
25 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v6.0) 1.021E-2 3.154E-2
1.570E-1
8.271E-1
 2 196
26 SMP00043 Galactose Metabolism SMPDB 1.040E-2 3.154E-2
1.570E-1
8.421E-1
 1 13
27 83067 Focal adhesion BioSystems: KEGG 1.051E-2 3.154E-2
1.570E-1
8.516E-1
 2 199
28 82997 Glycosphingolipid biosynthesis - ganglio series BioSystems: KEGG 1.199E-2 3.468E-2
1.726E-1
9.710E-1
 1 15
29 1270237 Cell-extracellular matrix interactions BioSystems: REACTOME 1.278E-2 3.570E-2
1.777E-1
1.000E0
 1 16
30 82976 Other glycan degradation BioSystems: KEGG 1.437E-2 3.801E-2
1.892E-1
1.000E0
 1 18
31 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 1.480E-2 3.801E-2
1.892E-1
1.000E0
 2 238
32 82981 Glycosaminoglycan degradation BioSystems: KEGG 1.516E-2 3.801E-2
1.892E-1
1.000E0
 1 19
33 1457800 MET activates PTK2 signaling BioSystems: REACTOME 1.595E-2 3.801E-2
1.892E-1
1.000E0
 1 20
34 1270007 HDL-mediated lipid transport BioSystems: REACTOME 1.595E-2 3.801E-2
1.892E-1
1.000E0
 1 20
35 1269983 HS-GAG degradation BioSystems: REACTOME 1.675E-2 3.876E-2
1.929E-1
1.000E0
 1 21
36 137996 VEGFR3 signaling in lymphatic endothelium BioSystems: Pathway Interaction Database 1.833E-2 4.012E-2
1.997E-1
1.000E0
 1 23
37 SMP00034 Sphingolipid Metabolism SMPDB 1.833E-2 4.012E-2
1.997E-1
1.000E0
 1 23
38 MAP00052 Galactose metabolism MAP00052 Galactose metabolism GenMAPP 1.912E-2 4.075E-2
2.028E-1
1.000E0
 1 24
39 1270253 Laminin interactions BioSystems: REACTOME 1.991E-2 4.135E-2
2.058E-1
1.000E0
 1 25
40 1268714 Asparagine N-linked glycosylation BioSystems: REACTOME 2.081E-2 4.215E-2
2.098E-1
1.000E0
 2 285
41 82931 Galactose metabolism BioSystems: KEGG 2.463E-2 4.750E-2
2.365E-1
1.000E0
 1 31
42 1457799 MET promotes cell motility BioSystems: REACTOME 2.463E-2 4.750E-2
2.365E-1
1.000E0
 1 31
43 1269977 Keratan sulfate/keratin metabolism BioSystems: REACTOME 2.620E-2 4.823E-2
2.401E-1
1.000E0
 1 33
44 1268721 Sialic acid metabolism BioSystems: REACTOME 2.620E-2 4.823E-2
2.401E-1
1.000E0
 1 33
45 1309087 Cargo concentration in the ER BioSystems: REACTOME 2.699E-2 4.857E-2
2.418E-1
1.000E0
 1 34
46 M5882 Genes encoding proteoglycans MSigDB C2 BIOCARTA (v6.0) 2.777E-2 4.890E-2
2.434E-1
1.000E0
 1 35
47 M6220 Agrin in Postsynaptic Differentiation MSigDB C2 BIOCARTA (v6.0) 2.855E-2 4.921E-2
2.449E-1
1.000E0
 1 36
48 692234 PI3K-Akt signaling pathway BioSystems: KEGG 2.927E-2 4.939E-2
2.458E-1
1.000E0
 2 342
Show 43 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 3133 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 28675934 Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Pubmed 1.272E-10 1.765E-7 1.523E-6 3.986E-7 5 135
2 15365990 Stability related bias in residues replacing glycines within the collagen triple helix (Gly-Xaa-Yaa) in inherited connective tissue disorders. Pubmed 1.292E-10 1.765E-7 1.523E-6 4.048E-7 3 5
3 19893454 Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. Pubmed 2.584E-10 1.765E-7 1.523E-6 8.095E-7 3 6
4 28071719 Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Pubmed 2.729E-10 1.765E-7 1.523E-6 8.549E-7 5 157
5 22159717 The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Pubmed 2.818E-10 1.765E-7 1.523E-6 8.827E-7 5 158
6 22261194 Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Pubmed 1.494E-9 7.801E-7 6.730E-6 4.680E-6 4 64
7 24006456 Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Pubmed 1.784E-9 7.987E-7 6.890E-6 5.591E-6 5 228
8 27559042 Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Pubmed 8.113E-9 3.177E-6 2.741E-5 2.542E-5 4 97
9 11311202 Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. Pubmed 1.052E-8 3.664E-6 3.161E-5 3.297E-5 3 18
10 25715398 Muscle composition is regulated by a Lox-TGFβ feedback loop. Pubmed 1.250E-8 3.915E-6 3.378E-5 3.915E-5 3 19
11 21979435 Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis. Pubmed 1.470E-8 4.187E-6 3.612E-5 4.605E-5 3 20
12 15227656 Collagen synthesis is not altered in women with stress urinary incontinence. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
13 19560165 Differential expression of procollagen genes between mid- and late-gestational fetal fibroblasts. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
14 25432063 Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
15 29091295 MicroRNA-29b-3p prevents Schistosoma japonicum-induced liver fibrosis by targeting COL1A1 and COL3A1. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
16 23040566 Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
17 28432057 Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
18 27636223 Transcriptional Regulation of Connective Tissue Metabolism Genes in Women With Pelvic Organ Prolapse. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
19 11283002 Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
20 20015075 Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
21 6912069 Reactivity of human leukocyte elastase and porcine pancreatic elastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is selective for cross-linked regions of elastin. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
22 23344861 Human brain arteriovenous malformations are associated with interruptions in elastic fibers and changes in collagen content. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
23 17950069 Altered procollagen gene expression in mid-gestational mouse excisional wounds. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
24 17576241 RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
25 18401458 AGEs and glucose levels modulate type I and III procollagen mRNA synthesis in dermal fibroblasts cells culture. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
26 16521042 Localization of precursor proteins and mRNA of type I and III collagens in usual interstitial pneumonia and sarcoidosis. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
27 11986329 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
28 27363273 [Emodin inhibits the proliferation, transdifferentiation and collagen synthesis of pulmonary fibroblasts]. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
29 23377784 Effects of collagen deposition on passive and active mechanical properties of large pulmonary arteries in hypoxic pulmonary hypertension. Pubmed 6.170E-8 6.666E-6 5.751E-5 1.933E-4 2 2
30 16452166 Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Pubmed 7.023E-8 7.334E-6 6.327E-5 2.200E-4 3 33
31 7919967 Age-related changes in collagen gene expression in the muscles of mdx dystrophic and normal mice. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
32 8785585 Coordinate patterns of expression of type I and III collagens during mouse development. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
33 28715234 Is cardiovascular disease in patients with diabetes associated with serum levels of MMP-2, LOX, and the elastin degradation products ELM and ELM-2? Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
34 20181949 Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
35 17662583 Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
36 1879336 Differential expression of type I and type III collagen genes during tooth development. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
37 16251195 The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
38 20704113 Effects of antisense transforming growth factor-beta1 gene transfer on the biological activities of tendon sheath fibroblasts. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
39 25593510 Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
40 9614124 Isolation, purification, and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
41 26406420 Collagen degradation products measured in serum can separate ovarian and breast cancer patients from healthy controls: A preliminary study. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
42 24088220 Distributions of types I, II and III collagen by region in the human supraspinatus tendon. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
43 19087518 [Expression of elastin, lysyl oxidase and elafin in the cardinal ligament of women with pelvic organ prolapse]. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
44 27870967 Osthole inhibits the expressions of collagen I and III through Smad signaling pathway after treatment with TGF-β1 in mouse cardiac fibroblasts. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
45 17453912 Distribution of collagen types I, III, and V in pregnant mouse endometrium. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
46 21343850 Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
47 23749290 Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
48 29191093 Branched-chain amino acids regulate type I tropocollagen and type III tropocollagen syntheses via modulation of mTOR in the skin. Pubmed 1.851E-7 1.208E-5 1.042E-4 5.798E-4 2 3
49 1409674 Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. Pubmed 3.701E-7 1.870E-5 1.613E-4 1.160E-3 2 4
50 12592609 Extracellular matrix protein expression during mouse detrusor development. Pubmed 3.701E-7 1.870E-5 1.613E-4 1.160E-3 2 4
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 260 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:COL7A1 COL7A1 interactions 1.031E-7 2.681E-5 1.646E-4 2.681E-5 3 20
2 int:BMP1 BMP1 interactions 1.869E-6 1.928E-4 1.184E-3 4.860E-4 3 51
3 int:THBS1 THBS1 interactions 2.225E-6 1.928E-4 1.184E-3 5.784E-4 3 54
4 int:COL1A1 COL1A1 interactions 5.104E-6 3.318E-4 2.037E-3 1.327E-3 3 71
5 int:LAMC2 LAMC2 interactions 1.512E-5 7.864E-4 4.829E-3 3.932E-3 2 12
6 int:FGF7 FGF7 interactions 2.404E-5 7.935E-4 4.872E-3 6.251E-3 2 15
7 int:DDR2 DDR2 interactions 2.404E-5 7.935E-4 4.872E-3 6.251E-3 2 15
8 int:LOX LOX interactions 2.747E-5 7.935E-4 4.872E-3 7.142E-3 2 16
9 int:PDGFA PDGFA interactions 2.747E-5 7.935E-4 4.872E-3 7.142E-3 2 16
10 int:SERPINF1 SERPINF1 interactions 3.112E-5 8.092E-4 4.968E-3 8.092E-3 2 17
11 int:MAG MAG interactions 4.345E-5 9.805E-4 6.020E-3 1.130E-2 2 20
12 int:BGN BGN interactions 4.801E-5 9.805E-4 6.020E-3 1.248E-2 2 21
13 int:ELN ELN interactions 5.279E-5 9.805E-4 6.020E-3 1.373E-2 2 22
14 int:VWF VWF interactions 5.279E-5 9.805E-4 6.020E-3 1.373E-2 2 22
15 int:SPARC SPARC interactions 7.420E-5 1.286E-3 7.897E-3 1.929E-2 2 26
16 int:NID2 NID2 interactions 8.011E-5 1.302E-3 7.993E-3 2.083E-2 2 27
17 int:LAMB3 LAMB3 interactions 8.625E-5 1.319E-3 8.099E-3 2.243E-2 2 28
18 int:HTRA1 HTRA1 interactions 1.278E-4 1.846E-3 1.133E-2 3.323E-2 2 34
19 int:DCN DCN interactions 1.435E-4 1.963E-3 1.205E-2 3.730E-2 2 36
20 int:MMP2 MMP2 interactions 3.614E-4 4.698E-3 2.885E-2
9.397E-2
 2 57
21 int:PDGFB PDGFB interactions 7.112E-4 8.616E-3
5.290E-2
1.849E-1
 2 80
22 int:ERAL1 ERAL1 interactions 7.291E-4 8.616E-3
5.290E-2
1.896E-1
 2 81
23 int:TLL2 TLL2 interactions 1.017E-3 1.149E-2
7.056E-2
2.643E-1
 1 2
24 int:SMAD7 SMAD7 interactions 1.291E-3 1.398E-2
8.586E-2
3.356E-1
 2 108
25 int:CAPN1 CAPN1 interactions 1.948E-3 1.948E-2
1.196E-1
5.065E-1
 2 133
26 int:ITGB1 ITGB1 interactions 1.948E-3 1.948E-2
1.196E-1
5.065E-1
 2 133
27 int:RASGEF1B RASGEF1B interactions 2.032E-3 1.957E-2
1.202E-1
5.284E-1
 1 4
28 int:MFSD13A MFSD13A interactions 2.540E-3 2.201E-2
1.351E-1
6.603E-1
 1 5
29 int:TMPRSS6 TMPRSS6 interactions 2.540E-3 2.201E-2
1.351E-1
6.603E-1
 1 5
30 int:DPT DPT interactions 2.540E-3 2.201E-2
1.351E-1
6.603E-1
 1 5
31 int:LAMA2 LAMA2 interactions 3.047E-3 2.263E-2
1.390E-1
7.922E-1
 1 6
32 int:SPINK1 SPINK1 interactions 3.047E-3 2.263E-2
1.390E-1
7.922E-1
 1 6
33 int:PCOLCE PCOLCE interactions 3.047E-3 2.263E-2
1.390E-1
7.922E-1
 1 6
34 int:DHDDS DHDDS interactions 3.047E-3 2.263E-2
1.390E-1
7.922E-1
 1 6
35 int:TLL1 TLL1 interactions 3.047E-3 2.263E-2
1.390E-1
7.922E-1
 1 6
36 int:LOXL1 LOXL1 interactions 3.554E-3 2.369E-2
1.455E-1
9.240E-1
 1 7
37 int:BBS12 BBS12 interactions 3.554E-3 2.369E-2
1.455E-1
9.240E-1
 1 7
38 int:KDELC2 KDELC2 interactions 3.554E-3 2.369E-2
1.455E-1
9.240E-1
 1 7
39 int:KLHDC9 KLHDC9 interactions 3.554E-3 2.369E-2
1.455E-1
9.240E-1
 1 7
40 int:LRRC57 LRRC57 interactions 4.061E-3 2.514E-2
1.543E-1
1.000E0
 1 8
41 int:KDELC1 KDELC1 interactions 4.061E-3 2.514E-2
1.543E-1
1.000E0
 1 8
42 int:COL5A2 COL5A2 interactions 4.061E-3 2.514E-2
1.543E-1
1.000E0
 1 8
43 int:LGALS3 LGALS3 interactions 4.467E-3 2.639E-2
1.620E-1
1.000E0
 2 203
44 int:MFAP2 MFAP2 interactions 4.567E-3 2.639E-2
1.620E-1
1.000E0
 1 9
45 int:TWSG1 TWSG1 interactions 4.567E-3 2.639E-2
1.620E-1
1.000E0
 1 9
46 int:CD200R1 CD200R1 interactions 5.074E-3 2.868E-2
1.761E-1
1.000E0
 1 10
47 int:ADRA1A ADRA1A interactions 5.580E-3 3.087E-2
1.895E-1
1.000E0
 1 11
48 int:TGFBI TGFBI interactions 6.086E-3 3.229E-2
1.983E-1
1.000E0
 1 12
49 int:FBLIM1 FBLIM1 interactions 6.086E-3 3.229E-2
1.983E-1
1.000E0
 1 12
50 int:RIPPLY2 RIPPLY2 interactions 7.097E-3 3.417E-2
2.098E-1
1.000E0
 1 14
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3p21.33 3p21.33 1.730E-3 1.248E-2 3.656E-2 1.730E-2 1 6
2 6q22-q23 6q22-q23 2.882E-3 1.248E-2 3.656E-2 2.882E-2 1 10
3 2q31 2q31 3.745E-3 1.248E-2 3.656E-2 3.745E-2 1 13
4 14q22.1 14q22.1 9.195E-3 1.498E-2 4.387E-2
9.195E-2
 1 32
5 5q23.2 5q23.2 9.767E-3 1.498E-2 4.387E-2
9.767E-2
 1 34
6 8p21.3 8p21.3 1.120E-2 1.498E-2 4.387E-2
1.120E-1
 1 39
7 17q21.33 17q21.33 1.205E-2 1.498E-2 4.387E-2
1.205E-1
 1 42
8 3p21.1 3p21.1 1.291E-2 1.498E-2 4.387E-2
1.291E-1
 1 45
9 1q23.1 1q23.1 1.348E-2 1.498E-2 4.387E-2
1.348E-1
 1 47
10 7q11.23 7q11.23 2.933E-2 2.933E-2
8.589E-2
2.933E-1
 1 103
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 98 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 490 Collagens genenames.org 5.256E-7 4.731E-6 1.338E-5 4.731E-6 3 46
2 561 Fermitins|Pleckstrin homology domain containing|FERM domain containing genenames.org 1.154E-3 5.192E-3 1.469E-2 1.038E-2 1 3
3 894 Astacins genenames.org 2.307E-3 6.920E-3 1.958E-2 2.076E-2 1 6
4 455 Bone morphogenetic proteins|Endogenous ligands genenames.org 4.225E-3 8.295E-3 2.347E-2 3.803E-2 1 11
5 626 Laminin subunits genenames.org 4.609E-3 8.295E-3 2.347E-2 4.148E-2 1 12
6 1293 Minor histocompatibility antigens|FERM domain containing genenames.org 1.908E-2 2.862E-2
8.098E-2
1.717E-1
 1 50
Show 1 more annotation

13: Coexpression [Display Chart] 10 input genes in category / 1198 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v6.0) 1.201E-15 1.439E-12 1.103E-11 1.439E-12 8 200
2 M2448 Genes upregulated in KRAS [GeneID=3845] knockdown vs control in a human cell line. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.338E-8 1.501E-5 1.150E-4 3.999E-5 4 84
3 M13796 Genes up-regulated in a mouse model of heart disease whose expression reverted to normal by silencing of MIR21 [GeneID=406991] microRNA. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.941E-8 1.501E-5 1.150E-4 4.721E-5 3 17
4 18044827-Table2 Human Breast Bergamaschi08 278genes GeneSigDB 5.010E-8 1.501E-5 1.150E-4 6.003E-5 5 270
5 20599952-Table1 Human BoneMarrow Maisel10 105genes GeneSigDB 8.235E-8 1.973E-5 1.513E-4 9.865E-5 4 105
6 17206280-TableS1C Mouse Breast Park07 173genes GeneSigDB 1.947E-7 3.887E-5 2.980E-4 2.332E-4 4 130
7 18435859-ShorterGeneList Mouse Breast Piechocki08 558genes GeneSigDB 2.601E-7 4.452E-5 3.413E-4 3.116E-4 5 376
8 M11788 Selected genes down-regulated during invasion of lymphatic vessels during metastasis. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.120E-7 6.170E-5 4.730E-4 4.936E-4 3 36
9 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.353E-7 7.126E-5 5.463E-4 6.413E-4 5 435
10 15489886-TableS1b Human Sarcoma Mason04 549genes GeneSigDB 7.363E-7 8.158E-5 6.254E-4 8.821E-4 5 464
11 15790779-Table1 Human BoneMarrow Jeong04 47genes GeneSigDB 7.629E-7 8.158E-5 6.254E-4 9.139E-4 3 44
12 M1527 Genes up-regulated in the mouse model of acute lung injury induced by inhaling nickel sulfate [PubChem=24586]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.172E-7 8.158E-5 6.254E-4 9.790E-4 3 45
13 18794116-Table1 Mouse Lymphoma Clasper08 56genes GeneSigDB 1.425E-6 1.220E-4 9.351E-4 1.708E-3 3 54
14 19286929-SuppTable2e Mouse Lung Rangasamy09 57genes GeneSigDB 1.425E-6 1.220E-4 9.351E-4 1.708E-3 3 54
15 19523942-Table1 Human Brain Potter09 66genes GeneSigDB 1.964E-6 1.546E-4 1.185E-3 2.353E-3 3 60
16 14676830-Table4 Human HeadandNeck Cromer04 64genes GeneSigDB 2.065E-6 1.546E-4 1.185E-3 2.474E-3 3 61
17 M178 Tumorigenesis markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in the 'early' tumors vs normal samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.278E-6 1.590E-4 1.219E-3 2.728E-3 3 63
18 M2572 Invasiveness signature resulting from cancer cell/microenvironment interaction. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.389E-6 1.590E-4 1.219E-3 2.862E-3 3 64
19 18698033-tableS1-PLAU Human Breast Desmedt08 68genes PLAU Module GeneSigDB 2.871E-6 1.690E-4 1.295E-3 3.439E-3 3 68
20 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.918E-6 1.690E-4 1.295E-3 3.495E-3 4 256
21 M10165 Genes up-regulated in lobular carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.001E-6 1.690E-4 1.295E-3 3.595E-3 3 69
22 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.103E-6 1.690E-4 1.295E-3 3.717E-3 4 260
23 11786402-Table3 Mouse Lung not cancer Fink02 9genes GeneSigDB 3.527E-6 1.777E-4 1.362E-3 4.225E-3 2 7
24 M515 Up-regulated genes displaying alternative splicing in MDA-MB-435 cells (breast cancer) whose metastatic potential has been reduced by expression of NME1 [GeneID=4830]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.709E-6 1.777E-4 1.362E-3 4.443E-3 3 74
25 M13547 Genes down-regulated in lobular carcinoma vs normal lobular breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.709E-6 1.777E-4 1.362E-3 4.443E-3 3 74
26 19118092-TableS2 Mouse Lung not cancer Cavarra09 11genes Levene'sTest GeneSigDB 4.701E-6 2.011E-4 1.542E-3 5.632E-3 2 8
27 19118092-TableS3 Mouse Lung not cancer Cavarra09 11genes T-test GeneSigDB 4.701E-6 2.011E-4 1.542E-3 5.632E-3 2 8
28 19118092-TableS1 Mouse Lung not cancer Cavarra09 22genes Shapiro-Wilk'sYest GeneSigDB 4.701E-6 2.011E-4 1.542E-3 5.632E-3 2 8
29 17346539-Table2 Human Ovarian Bignotti07 126genes MetsvPrimary up GeneSigDB 6.046E-6 2.498E-4 1.915E-3 7.243E-3 3 87
30 16509772-TableS1 Human StemCell Coller06 136genes GeneSigDB 6.258E-6 2.499E-4 1.916E-3 7.497E-3 3 88
31 M4065 Down-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 6.923E-6 2.675E-4 2.051E-3 8.294E-3 3 91
32 M13206 Genes down-regulated in TC71 and EWS502 cells (Ewing's sarcoma) by EWSR1-FLI1 [GeneID=2130;2314] as inferred from RNAi knockdown of this fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.600E-6 2.845E-4 2.181E-3 9.105E-3 4 326
33 M7013 Upregulated in the vastus lateralis muscle of middle aged rhesus monkeys subjected to caloric restriction since young adulthood vs age matched controls MSigDB C2: CGP Curated Gene Sets (v6.0) 7.881E-6 2.861E-4 2.193E-3 9.441E-3 3 95
34 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.017E-5 3.585E-4 2.748E-3 1.219E-2 4 351
35 15885264-Table1 Mouse Lung not cancer Lee05 127genes GeneSigDB 1.127E-5 3.858E-4 2.957E-3 1.350E-2 3 107
36 19305503-TableS1 Rat Brain Greco09 425genes GeneSigDB 1.494E-5 4.973E-4 3.813E-3 1.790E-2 4 387
37 M14027 Down-regulated genes in lung tissue of smokers with chronic obstructive pulmonary disease (COPD) vs smokers without disease (GOLD-2 vs GOLD-0). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.590E-5 5.056E-4 3.876E-3 1.905E-2 3 120
38 M7514 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.604E-5 5.056E-4 3.876E-3 1.921E-2 4 394
39 M14555 Down-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 1.929E-5 5.926E-4 4.543E-3 2.311E-2 3 128
40 M2145 Genes consistently underexpressed with age, based on meta-analysis of microarray data. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.011E-5 6.023E-4 4.617E-3 2.409E-2 2 16
41 M6906 Genes down-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC2 [GeneID=3066] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.115E-5 6.181E-4 4.738E-3 2.534E-2 3 132
42 16373702-Table1a Human Lymphoma Mahadevan05 21genes PTCL-NOSvsNormalPeripheralBloodTCells GeneSigDB 2.864E-5 8.169E-4 6.262E-3 3.431E-2 2 19
43 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.162E-5 8.809E-4 6.753E-3 3.788E-2 3 151
44 17389037-Tab5 Human Breast Turashvili07 201genes GeneSigDB 3.972E-5 1.082E-3 8.291E-3 4.759E-2 3 163
45 17389037-Tab6 Human Breast Turashvili07 208genes GeneSigDB 4.582E-5 1.214E-3 9.308E-3
5.489E-2
 3 171
46 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 4.662E-5 1.214E-3 9.308E-3
5.585E-2
 3 172
47 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.909E-5 1.251E-3 9.592E-3
5.881E-2
 3 175
48 M7581 Genes up-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.434E-5 1.356E-3 1.040E-2
6.510E-2
 2 26
49 16514666-Table2 Rat Immune Molloy06 46genes GeneSigDB 6.317E-5 1.484E-3 1.138E-2
7.568E-2
 2 28
50 19489030-SuppTable2 Human Prostate Chambers09 40genes GeneSigDB 6.317E-5 1.484E-3 1.138E-2
7.568E-2
 2 28
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 10 input genes in category / 1161 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.422E-10 1.293E-7 9.870E-7 1.652E-7 7 438
2 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 2.227E-10 1.293E-7 9.870E-7 2.585E-7 7 467
3 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 1.513E-8 5.854E-6 4.469E-5 1.756E-5 6 453
4 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 1000 k3 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.937E-8 8.524E-6 6.508E-5 3.410E-5 5 229
5 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.870E-8 8.986E-6 6.861E-5 4.493E-5 5 242
6 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Migrating MyoFibroblast Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Migrating MyoFibroblast Top 200 Genes 5.753E-8 9.541E-6 7.284E-5 6.679E-5 5 262
7 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Migrating MyoFibroblast E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Migrating MyoFibroblast E16.5 Top 200 Genes 5.753E-8 9.541E-6 7.284E-5 6.679E-5 5 262
8 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 7.537E-8 1.094E-5 8.351E-5 8.751E-5 4 97
9 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D Top 200 Genes 1.330E-7 1.496E-5 1.142E-4 1.544E-4 5 310
10 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 1.330E-7 1.496E-5 1.142E-4 1.544E-4 5 310
11 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal B PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal B PND01-03 Top 200 Genes 1.417E-7 1.496E-5 1.142E-4 1.645E-4 5 314
12 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Migrating MyoFibroblast Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Migrating MyoFibroblast Top 200 Genes 2.607E-7 2.018E-5 1.540E-4 3.026E-4 5 355
13 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Migrating MyoFibroblast E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Migrating MyoFibroblast E16.5 Top 200 Genes 2.607E-7 2.018E-5 1.540E-4 3.026E-4 5 355
14 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Subtype Dcn.Col15a1 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Subtype Dcn.Col15a1 Top 200 Genes 2.607E-7 2.018E-5 1.540E-4 3.026E-4 5 355
15 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Subtype Endothelial Tip. .Dcn.Col15a1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Subtype Endothelial Tip. .Dcn.Col15a1 Top 200 Genes BrainMap 2.607E-7 2.018E-5 1.540E-4 3.026E-4 5 355
16 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 2.992E-7 2.043E-5 1.560E-4 3.473E-4 5 365
17 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes 2.992E-7 2.043E-5 1.560E-4 3.473E-4 5 365
18 gudmap kidney adult RenalCapsule k2 1000 kidney adult RenalCapsule k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.243E-7 2.092E-5 1.597E-4 3.766E-4 5 371
19 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.320E-7 3.251E-5 2.482E-4 6.176E-4 5 410
20 Lungmap Mouse Lung E16.5 Epithelial Subtype Proliferative AT1 Progenitor Lungmap Mouse Lung E16.5 Epithelial Subtype Proliferative AT1 Progenitor Lungmap CCHMC 7.128E-7 3.799E-5 2.900E-4 8.275E-4 5 435
21 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 7.974E-7 3.799E-5 2.900E-4 9.258E-4 5 445
22 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Overall Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Overall Top 200 Genes 8.835E-7 3.799E-5 2.900E-4 1.026E-3 4 179
23 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 8.898E-7 3.799E-5 2.900E-4 1.033E-3 5 455
24 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart Tabula Muris Consortium 1.052E-6 3.799E-5 2.900E-4 1.221E-3 4 187
25 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/stromal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/stromal cell Tabula Muris Consortium 1.075E-6 3.799E-5 2.900E-4 1.248E-3 4 188
26 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/mesenchymal stem cell of adipose Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/mesenchymal stem cell of adipose Tabula Muris Consortium 1.121E-6 3.799E-5 2.900E-4 1.301E-3 4 190
27 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium 1.121E-6 3.799E-5 2.900E-4 1.301E-3 4 190
28 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Overall Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Overall Top 200 Genes 1.145E-6 3.799E-5 2.900E-4 1.329E-3 4 191
29 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 TCGA-Colorectal 1.145E-6 3.799E-5 2.900E-4 1.329E-3 4 191
30 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Aorta/fibroblast Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Aorta/fibroblast Tabula Muris Consortium 1.193E-6 3.799E-5 2.900E-4 1.385E-3 4 193
31 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip BrainMap 1.193E-6 3.799E-5 2.900E-4 1.385E-3 4 193
32 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Overall Top 200 Genes 1.218E-6 3.799E-5 2.900E-4 1.414E-3 4 194
33 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip Endothelial Tip Top 200 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip Endothelial Tip Top 200 BrainMap 1.218E-6 3.799E-5 2.900E-4 1.414E-3 4 194
34 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. Endothelial Tip. Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. Endothelial Tip. Overall Top 200 Genes BrainMap 1.218E-6 3.799E-5 2.900E-4 1.414E-3 4 194
35 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Overall Top 200 Genes BrainMap 1.218E-6 3.799E-5 2.900E-4 1.414E-3 4 194
36 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. Endothelial Tip. Top 200 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. Endothelial Tip. Top 200 BrainMap 1.218E-6 3.799E-5 2.900E-4 1.414E-3 4 194
37 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip Endothelial Tip Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip Endothelial Tip Overall Top 200 Genes BrainMap 1.218E-6 3.799E-5 2.900E-4 1.414E-3 4 194
38 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium 1.243E-6 3.799E-5 2.900E-4 1.444E-3 4 195
39 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 Top 200 Genes 1.671E-6 4.973E-5 3.797E-4 1.940E-3 4 210
40 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 E18.5 Top 200 Genes 1.768E-6 5.005E-5 3.821E-4 2.052E-3 4 213
41 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-1 Top 200 Genes 1.768E-6 5.005E-5 3.821E-4 2.052E-3 4 213
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal fetal kidney Endothelium/Kidney Normal fetal kidney T2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal fetal kidney Endothelium/Kidney Normal fetal kidney T2 Adult, Development, and Cancer types 1.887E-6 5.005E-5 3.821E-4 2.191E-3 2 5
43 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND07-28 Top 200 Genes 1.904E-6 5.005E-5 3.821E-4 2.210E-3 4 217
44 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 Top 200 Genes 2.010E-6 5.005E-5 3.821E-4 2.334E-3 4 220
45 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A Top 200 Genes 2.010E-6 5.005E-5 3.821E-4 2.334E-3 4 220
46 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 2 E16.5 Top 200 Genes 2.010E-6 5.005E-5 3.821E-4 2.334E-3 4 220
47 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast E16.5 Top 200 Genes 2.122E-6 5.005E-5 3.821E-4 2.463E-3 4 223
48 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Intermediate Fibroblast Top 200 Genes 2.122E-6 5.005E-5 3.821E-4 2.463E-3 4 223
49 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes 2.160E-6 5.005E-5 3.821E-4 2.508E-3 4 224
50 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 1 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype Mature Fibroblast 1 Top 200 Genes 2.198E-6 5.005E-5 3.821E-4 2.552E-3 4 225
Show 45 more annotations

15: Computational [Display Chart] 9 input genes in category / 65 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M414 MODULE 122 Adhesion molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.138E-8 3.990E-6 1.899E-5 3.990E-6 5 141
2 M11282 GNF2 PTX3 Neighborhood of PTX3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.508E-6 1.140E-4 5.425E-4 2.280E-4 3 36
3 M18929 MODULE 12 Spinal cord (neuro-development) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.460E-6 1.400E-4 6.662E-4 4.199E-4 5 360
4 M16395 MODULE 47 ECM and collagens. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.836E-5 4.609E-4 2.194E-3 1.844E-3 4 225
5 M1846 MODULE 220 Developmental processes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.314E-4 1.708E-3 8.129E-3 8.540E-3 4 333
6 M12987 GNF2 CDH11 Neighborhood of CDH11 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.121E-4 2.298E-3 1.094E-2 1.379E-2 2 25
7 M18849 MODULE 153 Genes in the cancer module 153. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.951E-4 3.668E-3 1.746E-2 2.568E-2 2 34
8 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.718E-4 3.833E-3 1.824E-2 3.067E-2 4 464
9 M11806 MODULE 70 Genes in the cancer module 70. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.332E-4 4.573E-3 2.177E-2 4.116E-2 2 43
10 M4082 MODULE 234 Bone remodeling. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.984E-4 6.490E-3 3.089E-2
6.490E-2
 2 54
11 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.257E-3 3.697E-2
1.760E-1
4.067E-1
 3 453
Show 6 more annotations

16: MicroRNA [Display Chart] 10 input genes in category / 355 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-29b-3p:Functional MTI Functional MTI miRTarbase 4.356E-13 1.546E-10 9.974E-10 1.546E-10 6 261
2 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 3.110E-9 2.760E-7 1.780E-6 1.104E-6 5 480
3 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 3.110E-9 2.760E-7 1.780E-6 1.104E-6 5 480
4 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 3.110E-9 2.760E-7 1.780E-6 1.104E-6 5 480
5 hsa-miR-29c-3p:Functional MTI Functional MTI miRTarbase 3.083E-8 2.162E-6 1.394E-5 1.094E-5 4 254
6 hsa-miR-29a-3p:Functional MTI Functional MTI miRTarbase 3.653E-8 2.162E-6 1.394E-5 1.297E-5 4 265
7 hsa-miR-767-5p:PITA hsa-miR-767-5p:PITA TOP PITA 6.703E-6 3.399E-4 2.193E-3 2.380E-3 3 279
8 hsa-miR-29b-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.760E-5 2.112E-3 1.363E-2 1.690E-2 2 75
9 GGGCATT,MIR-365:MSigDB GGGCATT,MIR-365:MSigDB MSigDB 9.167E-5 3.381E-3 2.181E-2 3.254E-2 2 104
10 GCTTGAA,MIR-498:MSigDB GCTTGAA,MIR-498:MSigDB MSigDB 9.524E-5 3.381E-3 2.181E-2 3.381E-2 2 106
11 hsa-miR-6747-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.141E-4 3.681E-3 2.375E-2 4.049E-2 2 116
12 ACTACCT,MIR-196B:MSigDB ACTACCT,MIR-196B:MSigDB MSigDB 1.432E-4 3.912E-3 2.523E-2
5.085E-2
 2 130
13 ACTACCT,MIR-196A:MSigDB ACTACCT,MIR-196A:MSigDB MSigDB 1.432E-4 3.912E-3 2.523E-2
5.085E-2
 2 130
14 hsa-miR-361-3p:PITA hsa-miR-361-3p:PITA TOP PITA 1.932E-4 4.898E-3 3.160E-2
6.858E-2
 2 151
15 hsa-miR-200b-3p:Functional MTI Functional MTI miRTarbase 2.927E-4 6.319E-3 4.076E-2
1.039E-1
 2 186
16 hsa-miR-767-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.959E-4 6.319E-3 4.076E-2
1.050E-1
 2 187
17 hsa-miR-196a:PITA hsa-miR-196a:PITA TOP PITA 3.315E-4 6.319E-3 4.076E-2
1.177E-1
 2 198
18 hsa-miR-196b:PITA hsa-miR-196b:PITA TOP PITA 3.315E-4 6.319E-3 4.076E-2
1.177E-1
 2 198
19 CACCAGC,MIR-138:MSigDB CACCAGC,MIR-138:MSigDB MSigDB 3.382E-4 6.319E-3 4.076E-2
1.201E-1
 2 200
20 hsa-miR-143-3p:Functional MTI Functional MTI miRTarbase 4.389E-4 7.790E-3
5.025E-2
1.558E-1
 2 228
21 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 5.524E-4 8.265E-3
5.332E-2
1.961E-1
 2 256
22 hsa-miR-498:PITA hsa-miR-498:PITA TOP PITA 5.524E-4 8.265E-3
5.332E-2
1.961E-1
 2 256
23 hsa-miR-196a-5p:TargetScan hsa-miR-196a-5p TargetScan 6.460E-4 8.265E-3
5.332E-2
2.293E-1
 2 277
24 hsa-miR-196b-5p:TargetScan hsa-miR-196b-5p TargetScan 6.460E-4 8.265E-3
5.332E-2
2.293E-1
 2 277
25 hsa-miR-365a-3p:TargetScan hsa-miR-365a-3p TargetScan 6.835E-4 8.265E-3
5.332E-2
2.426E-1
 2 285
26 hsa-miR-365b-3p:TargetScan hsa-miR-365b-3p TargetScan 6.835E-4 8.265E-3
5.332E-2
2.426E-1
 2 285
27 hsa-miR-615-3p:mirSVR lowEffct hsa-miR-615-3p:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 8.126E-4 8.265E-3
5.332E-2
2.885E-1
 2 311
28 hsa-miR-615-5p:mirSVR highEffct hsa-miR-615-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.866E-4 8.265E-3
5.332E-2
3.147E-1
 2 325
29 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 9.581E-4 8.265E-3
5.332E-2
3.401E-1
 2 338
30 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 9.581E-4 8.265E-3
5.332E-2
3.401E-1
 2 338
31 hsa-miR-572:mirSVR lowEffct hsa-miR-572:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.044E-3 8.265E-3
5.332E-2
3.706E-1
 2 353
32 CTACCTC,LET-7A:MSigDB CTACCTC,LET-7A:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
33 CTACCTC,LET-7C:MSigDB CTACCTC,LET-7C:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
34 CTACCTC,LET-7I:MSigDB CTACCTC,LET-7I:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
35 CTACCTC,LET-7D:MSigDB CTACCTC,LET-7D:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
36 CTACCTC,LET-7E:MSigDB CTACCTC,LET-7E:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
37 CTACCTC,LET-7F:MSigDB CTACCTC,LET-7F:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
38 CTACCTC,MIR-98:MSigDB CTACCTC,MIR-98:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
39 CTACCTC,LET-7G:MSigDB CTACCTC,LET-7G:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
40 CTACCTC,LET-7B:MSigDB CTACCTC,LET-7B:MSigDB MSigDB 1.097E-3 8.265E-3
5.332E-2
3.895E-1
 2 362
41 hsa-miR-410:PITA hsa-miR-410:PITA TOP PITA 1.109E-3 8.265E-3
5.332E-2
3.938E-1
 2 364
42 hsa-miR-98:PITA hsa-miR-98:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
43 hsa-let-7g:PITA hsa-let-7g:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
44 hsa-let-7e:PITA hsa-let-7e:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
45 hsa-let-7b:PITA hsa-let-7b:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
46 hsa-let-7c:PITA hsa-let-7c:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
47 hsa-let-7d:PITA hsa-let-7d:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
48 hsa-let-7i:PITA hsa-let-7i:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
49 hsa-let-7a:PITA hsa-let-7a:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
50 hsa-let-7f:PITA hsa-let-7f:PITA TOP PITA 1.164E-3 8.265E-3
5.332E-2
4.133E-1
 2 373
Show 45 more annotations

17: Drug [Display Chart] 10 input genes in category / 5656 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000001647 BAPN Stitch 1.511E-13 8.547E-10 7.878E-9 8.547E-10 6 71
2 CID000001029 hydroxylysine Stitch 5.578E-10 1.420E-6 1.309E-5 3.155E-6 5 109
3 CID000013811 isodesmosine Stitch 7.533E-10 1.420E-6 1.309E-5 4.261E-6 4 33
4 CID000020796 DMSe Stitch 1.471E-9 2.080E-6 1.917E-5 8.318E-6 5 132
5 CID000004727 DL-penicillamine Stitch 1.909E-9 2.160E-6 1.991E-5 1.080E-5 5 139
6 CID000171068 HHMD Stitch 3.380E-9 3.186E-6 2.937E-5 1.912E-5 3 8
7 CID000025435 desmosine Stitch 5.368E-9 4.337E-6 3.998E-5 3.036E-5 4 53
8 CID000119593 pentosidine Stitch 1.162E-8 8.216E-6 7.573E-5 6.573E-5 4 64
9 CID000094284 L-3,4-dehydroproline Stitch 1.987E-8 1.241E-5 1.144E-4 1.124E-4 4 73
10 CID000124011 Dhlnl Stitch 2.194E-8 1.241E-5 1.144E-4 1.241E-4 3 14
11 CID011968896 2-[(1R,2R,3S,4R,5R,6S)-2-[(2R,5S)-3-[(3S,4S,5R,6S)-4,5-dihydroxy-3-(methylamino)-6-methylol-tetrahydropyran-2-yl]-4-formyl-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine Stitch 3.347E-8 1.721E-5 1.587E-4 1.893E-4 4 83
12 CID000000825 4-hydroxyproline Stitch 4.860E-8 2.291E-5 2.112E-4 2.749E-4 4 91
13 CID000122155 Hlnl Stitch 5.834E-8 2.538E-5 2.340E-4 3.300E-4 3 19
14 CID000105068 pyridinoline Stitch 6.834E-8 2.761E-5 2.545E-4 3.865E-4 4 99
15 CID000439300 AC1L9732 Stitch 1.208E-7 4.554E-5 4.197E-4 6.830E-4 4 114
16 CID003037767 hydroxyaldolhistidine Stitch 1.725E-7 6.098E-5 5.621E-4 9.758E-4 2 2
17 CID000024441 calcium phosphate Stitch 3.543E-7 1.128E-4 1.040E-3 2.004E-3 4 149
18 CID011980859 CID11980859 Stitch 3.590E-7 1.128E-4 1.040E-3 2.031E-3 3 34
19 CID005486818 Sirius red Stitch 3.926E-7 1.169E-4 1.077E-3 2.221E-3 3 35
20 CID000161853 GK-101 Stitch 4.282E-7 1.188E-4 1.095E-3 2.422E-3 3 36
21 CID000024766 chondroitin sulfate Stitch 4.412E-7 1.188E-4 1.095E-3 2.496E-3 5 413
22 CID000072363 L-lysyl-L-lysyl-L-lysine Stitch 4.953E-7 1.273E-4 1.174E-3 2.801E-3 4 162
23 ctd:D019808 Losartan CTD 5.331E-7 1.311E-4 1.208E-3 3.015E-3 4 165
24 CID000002299 AC1L1DD6 Stitch 7.383E-7 1.740E-4 1.604E-3 4.176E-3 4 179
25 CID000108062 Madecassol Stitch 9.083E-7 1.791E-4 1.651E-3 5.137E-3 3 46
26 CID000001413 12(S)-hydroxyeicosatetraenoic acid Stitch 9.173E-7 1.791E-4 1.651E-3 5.188E-3 4 189
27 5303 UP Methylergometrine maleate [113-42-8]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.018E-6 1.791E-4 1.651E-3 5.758E-3 4 194
28 DB00048 Collagenase Drug Bank 1.035E-6 1.791E-4 1.651E-3 5.852E-3 2 4
29 CID000494583 AC1LATBV Stitch 1.035E-6 1.791E-4 1.651E-3 5.852E-3 2 4
30 CID000193783 ATFP Stitch 1.035E-6 1.791E-4 1.651E-3 5.852E-3 2 4
31 2306 UP Salbutamol [18559-94-9]; Up 200; 16.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.061E-6 1.791E-4 1.651E-3 5.999E-3 4 196
32 6072 UP Etanidazole [22668-01-5]; Up 200; 18.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.127E-6 1.791E-4 1.651E-3 6.373E-3 4 199
33 3625 UP Metoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.127E-6 1.791E-4 1.651E-3 6.373E-3 4 199
34 2495 UP Ethionamide [536-33-4]; Up 200; 24uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.127E-6 1.791E-4 1.651E-3 6.373E-3 4 199
35 6731 DN Rolitetracycline [751-97-3]; Down 200; 7.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.127E-6 1.791E-4 1.651E-3 6.373E-3 4 199
36 2323 UP Phentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.150E-6 1.791E-4 1.651E-3 6.502E-3 4 200
37 CID000044562 d-indobufen Stitch 1.172E-6 1.791E-4 1.651E-3 6.627E-3 3 50
38 CID005362391 ridogrel Stitch 1.321E-6 1.965E-4 1.812E-3 7.469E-3 3 52
39 CID000023340 NSC49633 Stitch 1.399E-6 2.030E-4 1.871E-3 7.915E-3 3 53
40 CID000032756 dermatan sulfate Stitch 1.681E-6 2.268E-4 2.090E-3 9.506E-3 4 220
41 ctd:D000629 Aminopropionitrile CTD 1.724E-6 2.268E-4 2.090E-3 9.751E-3 2 5
42 ctd:D012504 Saralasin CTD 1.724E-6 2.268E-4 2.090E-3 9.751E-3 2 5
43 CID000191270 allysine aldol Stitch 1.724E-6 2.268E-4 2.090E-3 9.751E-3 2 5
44 CID000470146 AC1LAKND Stitch 2.255E-6 2.898E-4 2.671E-3 1.275E-2 3 62
45 CID000104802 Rgd Peptide Stitch 2.337E-6 2.937E-4 2.707E-3 1.322E-2 4 239
46 CID000102467 NSC83256 Stitch 2.585E-6 2.984E-4 2.751E-3 1.462E-2 2 6
47 ctd:C502971 2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine CTD 2.585E-6 2.984E-4 2.751E-3 1.462E-2 2 6
48 CID005487286 Aapv-na Stitch 2.585E-6 2.984E-4 2.751E-3 1.462E-2 2 6
49 CID000146249 BPAT-143 Stitch 2.585E-6 2.984E-4 2.751E-3 1.462E-2 2 6
50 CID000006051 4-aminoazobenzene Stitch 2.725E-6 3.083E-4 2.842E-3 1.542E-2 3 66
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 1092 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0009782 Connective Tissue Diseases DisGeNET Curated 2.465E-10 2.692E-7 2.039E-6 2.692E-7 5 76
2 C0013720 Ehlers-Danlos Syndrome DisGeNET Curated 1.174E-8 5.790E-6 4.385E-5 1.282E-5 4 52
3 C0024796 Marfan Syndrome DisGeNET Curated 1.591E-8 5.790E-6 4.385E-5 1.737E-5 4 56
4 C0086437 Joint laxity DisGeNET Curated 2.257E-8 6.162E-6 4.667E-5 2.465E-5 4 61
5 C0241178 Velvety skin DisGeNET Curated 8.024E-8 1.460E-5 1.106E-4 8.762E-5 3 17
6 C1844592 Soft skin DisGeNET Curated 8.024E-8 1.460E-5 1.106E-4 8.762E-5 3 17
7 C0241181 Fragile skin DisGeNET Curated 9.626E-8 1.502E-5 1.137E-4 1.051E-4 3 18
8 C0019294 Hernia, Inguinal DisGeNET Curated 1.365E-7 1.864E-5 1.412E-4 1.491E-4 4 95
9 C0003493 Aortic Diseases DisGeNET Curated 1.815E-7 2.202E-5 1.667E-4 1.982E-4 3 22
10 C0009917 Contracture DisGeNET Curated 3.867E-7 4.223E-5 3.198E-4 4.223E-4 4 123
11 C0877015 Pelvic Organ Prolapse DisGeNET Curated 4.297E-7 4.266E-5 3.231E-4 4.693E-4 3 29
12 C0029456 Osteoporosis DisGeNET Curated 7.643E-7 6.336E-5 4.799E-4 8.347E-4 5 376
13 C0036439 Scoliosis, unspecified DisGeNET Curated 7.684E-7 6.336E-5 4.799E-4 8.391E-4 3 35
14 C0002940 Aneurysm DisGeNET Curated 8.124E-7 6.336E-5 4.799E-4 8.871E-4 4 148
15 C0022548 Keloid DisGeNET Curated 1.225E-6 8.917E-5 6.753E-4 1.338E-3 4 164
16 C0340643 Dissection of aorta DisGeNET Curated 1.345E-6 9.181E-5 6.953E-4 1.469E-3 3 42
17 C0079294 Epidermolysis Bullosa Dystrophica DisGeNET Curated 1.644E-6 9.450E-5 7.157E-4 1.795E-3 2 4
18 C1851828 Cigarette-paper scars DisGeNET Curated 1.644E-6 9.450E-5 7.157E-4 1.795E-3 2 4
19 C0268335 Ehlers-Danlos syndrome type 1 DisGeNET Curated 1.644E-6 9.450E-5 7.157E-4 1.795E-3 2 4
20 C0017168 Gastroesophageal reflux disease DisGeNET Curated 1.737E-6 9.485E-5 7.184E-4 1.897E-3 4 179
21 C0423757 Thin skin DisGeNET Curated 1.897E-6 9.867E-5 7.472E-4 2.072E-3 3 47
22 C0029434 Osteogenesis Imperfecta DisGeNET Curated 2.155E-6 1.070E-4 8.100E-4 2.353E-3 3 49
23 C0010495 Cutis Laxa DisGeNET Curated 2.434E-6 1.156E-4 8.753E-4 2.658E-3 3 51
24 C0026267 Mitral Valve Prolapse Syndrome DisGeNET Curated 2.737E-6 1.197E-4 9.063E-4 2.988E-3 3 53
25 C1844597 Molluscoid pseudotumors DisGeNET Curated 2.740E-6 1.197E-4 9.063E-4 2.992E-3 2 5
26 C1844704 Platyspondyly DisGeNET Curated 3.414E-6 1.381E-4 1.046E-3 3.729E-3 3 57
27 C0042345 Varicosity DisGeNET Curated 3.414E-6 1.381E-4 1.046E-3 3.729E-3 3 57
28 C0268338 Ehlers-Danlos Syndrome, Type IV DisGeNET Curated 4.108E-6 1.495E-4 1.133E-3 4.486E-3 2 6
29 C1395674 Bowel diverticulosis DisGeNET Curated 4.108E-6 1.495E-4 1.133E-3 4.486E-3 2 6
30 C1394691 Bowel diverticula DisGeNET Curated 4.108E-6 1.495E-4 1.133E-3 4.486E-3 2 6
31 C0003504 Aortic Valve Insufficiency DisGeNET Curated 5.955E-6 2.098E-4 1.589E-3 6.503E-3 4 244
32 C4280623 Rotting teeth DisGeNET Curated 7.529E-6 2.536E-4 1.921E-3 8.221E-3 3 74
33 C4024942 Late-onset muscular dystrophy DisGeNET BeFree 7.664E-6 2.536E-4 1.921E-3 8.369E-3 2 8
34 C1290398 Cerebral arterial aneurysm DisGeNET Curated 8.489E-6 2.726E-4 2.065E-3 9.270E-3 3 77
35 C3553764 Joint hyperflexibility DisGeNET Curated 8.826E-6 2.754E-4 2.085E-3 9.638E-3 3 78
36 C0156273 Bladder Diverticulum DisGeNET Curated 1.231E-5 3.538E-4 2.679E-3 1.344E-2 2 10
37 C1290857 Disorder of face DisGeNET Curated 1.231E-5 3.538E-4 2.679E-3 1.344E-2 2 10
38 C0340613 Arterial aneurysm DisGeNET BeFree 1.231E-5 3.538E-4 2.679E-3 1.344E-2 2 10
39 C0700208 Acquired scoliosis DisGeNET Curated 1.421E-5 3.820E-4 2.893E-3 1.551E-2 4 304
40 C1850530 Flexion contractures of joints DisGeNET Curated 1.499E-5 3.820E-4 2.893E-3 1.637E-2 3 93
41 C0410787 Hereditary Connective Tissue Disorder DisGeNET BeFree 1.504E-5 3.820E-4 2.893E-3 1.643E-2 2 11
42 C4025871 Abnormality of the face DisGeNET Curated 1.504E-5 3.820E-4 2.893E-3 1.643E-2 2 11
43 C0268362 Osteogenesis imperfecta type III (disorder) DisGeNET Curated 1.504E-5 3.820E-4 2.893E-3 1.643E-2 2 11
44 C0333068 Flexion contracture DisGeNET Curated 1.548E-5 3.842E-4 2.910E-3 1.691E-2 3 94
45 C0009918 Contracture of joint DisGeNET Curated 1.701E-5 4.129E-4 3.127E-3 1.858E-2 3 97
46 C0007766 Intracranial Aneurysm DisGeNET Curated 1.755E-5 4.166E-4 3.155E-3 1.916E-2 3 98
47 C0747078 Generalized osteopenia DisGeNET Curated 1.979E-5 4.597E-4 3.482E-3 2.161E-2 3 102
48 C2697932 Loeys-Dietz Syndrome DisGeNET Curated 2.132E-5 4.810E-4 3.643E-3 2.328E-2 2 13
49 C0018834 Heartburn DisGeNET Curated 2.158E-5 4.810E-4 3.643E-3 2.357E-2 3 105
50 C0032326 Pneumothorax DisGeNET Curated 2.487E-5 5.123E-4 3.880E-3 2.715E-2 2 14
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