Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc124_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 49 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004190 aspartic-type endopeptidase activity 1.861E-6 3.306E-5 1.481E-4 9.118E-5 3 36
2 GO:0001540 amyloid-beta binding 1.861E-6 3.306E-5 1.481E-4 9.118E-5 3 36
3 GO:0070001 aspartic-type peptidase activity 2.024E-6 3.306E-5 1.481E-4 9.919E-5 3 37
4 GO:0004175 endopeptidase activity 9.429E-6 1.155E-4 5.174E-4 4.620E-4 5 457
5 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving 1.608E-5 1.576E-4 7.060E-4 7.881E-4 2 9
6 GO:0008201 heparin binding 1.885E-4 1.539E-3 6.895E-3 9.236E-3 3 167
7 GO:0005539 glycosaminoglycan binding 4.180E-4 2.926E-3 1.311E-2 2.048E-2 3 219
8 GO:1901681 sulfur compound binding 6.895E-4 3.414E-3 1.529E-2 3.379E-2 3 260
9 GO:0042988 X11-like protein binding 6.966E-4 3.414E-3 1.529E-2 3.414E-2 1 1
10 GO:0031695 alpha-2B adrenergic receptor binding 6.966E-4 3.414E-3 1.529E-2 3.414E-2 1 1
11 GO:0042277 peptide binding 8.374E-4 3.730E-3 1.671E-2 4.103E-2 3 278
12 GO:0033218 amide binding 1.137E-3 4.642E-3 2.079E-2
5.571E-2
 3 309
13 GO:0008798 beta-aspartyl-peptidase activity 1.393E-3 4.875E-3 2.184E-2
6.825E-2
 1 2
14 GO:0031696 alpha-2C adrenergic receptor binding 1.393E-3 4.875E-3 2.184E-2
6.825E-2
 1 2
15 GO:0004867 serine-type endopeptidase inhibitor activity 1.969E-3 6.431E-3 2.881E-2
9.647E-2
 2 96
16 GO:0051425 PTB domain binding 2.784E-3 8.024E-3 3.594E-2
1.364E-1
 1 4
17 GO:0005176 ErbB-2 class receptor binding 2.784E-3 8.024E-3 3.594E-2
1.364E-1
 1 4
18 GO:0031694 alpha-2A adrenergic receptor binding 3.479E-3 9.470E-3 4.242E-2
1.705E-1
 1 5
19 GO:0004866 endopeptidase inhibitor activity 6.093E-3 1.480E-2
6.629E-2
2.986E-1
 2 171
20 GO:0061135 endopeptidase regulator activity 6.515E-3 1.480E-2
6.629E-2
3.192E-1
 2 177
21 GO:0030414 peptidase inhibitor activity 6.730E-3 1.480E-2
6.629E-2
3.298E-1
 2 180
22 GO:0033130 acetylcholine receptor binding 6.946E-3 1.480E-2
6.629E-2
3.404E-1
 1 10
23 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity 6.946E-3 1.480E-2
6.629E-2
3.404E-1
 1 10
24 GO:0050839 cell adhesion molecule binding 8.895E-3 1.816E-2
8.135E-2
4.359E-1
 2 208
25 GO:0061134 peptidase regulator activity 1.008E-2 1.976E-2
8.850E-2
4.939E-1
 2 222
26 GO:0051766 inositol trisphosphate kinase activity 1.247E-2 2.350E-2
1.053E-1
6.111E-1
 1 18
27 GO:0031690 adrenergic receptor binding 1.385E-2 2.513E-2
1.126E-1
6.786E-1
 1 20
28 GO:0008242 omega peptidase activity 1.591E-2 2.784E-2
1.247E-1
7.796E-1
 1 23
29 GO:0045296 cadherin binding 2.207E-2 3.729E-2
1.670E-1
1.000E0
 1 32
30 GO:0019894 kinesin binding 2.888E-2 4.533E-2
2.030E-1
1.000E0
 1 42
31 GO:0016504 peptidase activator activity 2.955E-2 4.533E-2
2.030E-1
1.000E0
 1 43
32 GO:0004857 enzyme inhibitor activity 2.960E-2 4.533E-2
2.030E-1
1.000E0
 2 393
Show 27 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 579 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050435 amyloid-beta metabolic process 3.639E-12 2.107E-9 1.462E-8 2.107E-9 5 25
2 GO:0042987 amyloid precursor protein catabolic process 8.485E-10 2.456E-7 1.705E-6 4.913E-7 4 21
3 GO:0007176 regulation of epidermal growth factor-activated receptor activity 1.791E-9 3.456E-7 2.398E-6 1.037E-6 4 25
4 GO:0042982 amyloid precursor protein metabolic process 5.775E-9 8.359E-7 5.800E-6 3.343E-6 4 33
5 GO:0006509 membrane protein ectodomain proteolysis 1.574E-8 1.823E-6 1.265E-5 9.114E-6 4 42
6 GO:0007173 epidermal growth factor receptor signaling pathway 2.039E-8 1.967E-6 1.365E-5 1.180E-5 5 132
7 GO:0038127 ERBB signaling pathway 4.005E-8 3.313E-6 2.299E-5 2.319E-5 5 151
8 GO:0033619 membrane protein proteolysis 4.772E-8 3.454E-6 2.397E-5 2.763E-5 4 55
9 GO:0061097 regulation of protein tyrosine kinase activity 1.203E-7 7.740E-6 5.371E-5 6.966E-5 4 69
10 GO:0007220 Notch receptor processing 1.480E-7 8.571E-6 5.948E-5 8.571E-5 3 16
11 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 2.800E-7 1.474E-5 1.023E-4 1.621E-4 4 85
12 GO:1901184 regulation of ERBB signaling pathway 3.221E-7 1.554E-5 1.079E-4 1.865E-4 4 88
13 GO:0032469 endoplasmic reticulum calcium ion homeostasis 3.509E-7 1.563E-5 1.084E-4 2.032E-4 3 21
14 GO:0071874 cellular response to norepinephrine stimulus 4.498E-7 1.736E-5 1.205E-4 2.605E-4 2 2
15 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis 4.498E-7 1.736E-5 1.205E-4 2.605E-4 2 2
16 GO:0010469 regulation of signaling receptor activity 1.592E-6 5.760E-5 3.997E-4 9.217E-4 4 131
17 GO:0071873 response to norepinephrine 2.697E-6 9.185E-5 6.374E-4 1.561E-3 2 4
18 GO:0045861 negative regulation of proteolysis 3.225E-6 1.037E-4 7.199E-4 1.867E-3 5 366
19 GO:0007219 Notch signaling pathway 5.275E-6 1.569E-4 1.088E-3 3.054E-3 4 177
20 GO:0030900 forebrain development 5.418E-6 1.569E-4 1.088E-3 3.137E-3 5 407
21 GO:0043393 regulation of protein binding 7.585E-6 2.091E-4 1.451E-3 4.392E-3 4 194
22 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 1.756E-5 4.620E-4 3.206E-3 1.016E-2 4 240
23 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 2.018E-5 4.868E-4 3.378E-3 1.168E-2 2 10
24 GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 2.018E-5 4.868E-4 3.378E-3 1.168E-2 2 10
25 GO:0043589 skin morphogenesis 2.465E-5 5.710E-4 3.962E-3 1.427E-2 2 11
26 GO:0050803 regulation of synapse structure or activity 2.869E-5 6.115E-4 4.243E-3 1.661E-2 4 272
27 GO:0034205 amyloid-beta formation 2.957E-5 6.115E-4 4.243E-3 1.712E-2 2 12
28 GO:0042640 anagen 2.957E-5 6.115E-4 4.243E-3 1.712E-2 2 12
29 GO:0001921 positive regulation of receptor recycling 4.699E-5 9.382E-4 6.511E-3 2.721E-2 2 15
30 GO:0006878 cellular copper ion homeostasis 5.368E-5 1.036E-3 7.190E-3 3.108E-2 2 16
31 GO:0031293 membrane protein intracellular domain proteolysis 6.082E-5 1.096E-3 7.604E-3 3.521E-2 2 17
32 GO:0001967 suckling behavior 6.082E-5 1.096E-3 7.604E-3 3.521E-2 2 17
33 GO:0051098 regulation of binding 6.246E-5 1.096E-3 7.604E-3 3.616E-2 4 332
34 GO:0016485 protein processing 6.696E-5 1.100E-3 7.633E-3 3.877E-2 4 338
35 GO:0044851 hair cycle phase 6.839E-5 1.100E-3 7.633E-3 3.960E-2 2 18
36 GO:0055070 copper ion homeostasis 6.839E-5 1.100E-3 7.633E-3 3.960E-2 2 18
37 GO:0048820 hair follicle maturation 8.486E-5 1.328E-3 9.216E-3 4.914E-2 2 20
38 GO:0051604 protein maturation 9.118E-5 1.389E-3 9.641E-3
5.279E-2
 4 366
39 GO:0018108 peptidyl-tyrosine phosphorylation 1.109E-4 1.598E-3 1.109E-2
6.421E-2
 4 385
40 GO:0061099 negative regulation of protein tyrosine kinase activity 1.129E-4 1.598E-3 1.109E-2
6.535E-2
 2 23
41 GO:0018212 peptidyl-tyrosine modification 1.131E-4 1.598E-3 1.109E-2
6.551E-2
 4 387
42 GO:0006874 cellular calcium ion homeostasis 1.427E-4 1.968E-3 1.365E-2
8.264E-2
 4 411
43 GO:0001919 regulation of receptor recycling 1.563E-4 2.105E-3 1.461E-2
9.052E-2
 2 27
44 GO:0055074 calcium ion homeostasis 1.624E-4 2.137E-3 1.483E-2
9.401E-2
 4 425
45 GO:0072503 cellular divalent inorganic cation homeostasis 1.776E-4 2.180E-3 1.513E-2
1.028E-1
 4 435
46 GO:0007617 mating behavior 1.807E-4 2.180E-3 1.513E-2
1.046E-1
 2 29
47 GO:0044705 multi-organism reproductive behavior 1.807E-4 2.180E-3 1.513E-2
1.046E-1
 2 29
48 GO:0021904 dorsal/ventral neural tube patterning 1.807E-4 2.180E-3 1.513E-2
1.046E-1
 2 29
49 GO:0050820 positive regulation of coagulation 2.068E-4 2.444E-3 1.696E-2
1.197E-1
 2 31
50 GO:0072507 divalent inorganic cation homeostasis 2.164E-4 2.503E-3 1.737E-2
1.253E-1
 4 458
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 107 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035253 ciliary rootlet 1.926E-5 2.061E-3 1.083E-2 2.061E-3 2 10
2 GO:0098791 Golgi subcompartment 5.317E-5 2.259E-3 1.187E-2 5.689E-3 4 326
3 GO:0031984 organelle subcompartment 6.334E-5 2.259E-3 1.187E-2 6.777E-3 4 341
4 GO:0005635 nuclear envelope 1.914E-4 5.121E-3 2.691E-2 2.048E-2 4 454
5 GO:0005790 smooth endoplasmic reticulum 3.137E-4 6.713E-3 3.527E-2 3.356E-2 2 39
6 GO:0005802 trans-Golgi network 3.774E-4 6.731E-3 3.537E-2 4.038E-2 3 216
7 GO:0070931 Golgi-associated vesicle lumen 6.820E-4 7.582E-3 3.984E-2
7.298E-2
 1 1
8 GO:0031594 neuromuscular junction 7.433E-4 7.582E-3 3.984E-2
7.953E-2
 2 60
9 GO:0043198 dendritic shaft 7.433E-4 7.582E-3 3.984E-2
7.953E-2
 2 60
10 GO:0098852 lytic vacuole membrane 7.794E-4 7.582E-3 3.984E-2
8.340E-2
 3 277
11 GO:0005765 lysosomal membrane 7.794E-4 7.582E-3 3.984E-2
8.340E-2
 3 277
12 GO:0031965 nuclear membrane 8.903E-4 7.938E-3 4.171E-2
9.526E-2
 3 290
13 GO:0031091 platelet alpha granule 1.159E-3 9.536E-3
5.011E-2
1.240E-1
 2 75
14 GO:0044441 ciliary part 1.569E-3 1.199E-2
6.301E-2
1.679E-1
 3 353
15 GO:0005791 rough endoplasmic reticulum 1.736E-3 1.216E-2
6.387E-2
1.858E-1
 2 92
16 GO:1990761 growth cone lamellipodium 2.045E-3 1.216E-2
6.387E-2
2.188E-1
 1 3
17 GO:1990812 growth cone filopodium 2.045E-3 1.216E-2
6.387E-2
2.188E-1
 1 3
18 GO:0070765 gamma-secretase complex 2.045E-3 1.216E-2
6.387E-2
2.188E-1
 1 3
19 GO:0060205 cytoplasmic vesicle lumen 2.211E-3 1.236E-2
6.494E-2
2.366E-1
 2 104
20 GO:0031983 vesicle lumen 2.382E-3 1.236E-2
6.494E-2
2.549E-1
 2 108
21 GO:0005604 basement membrane 2.426E-3 1.236E-2
6.494E-2
2.595E-1
 2 109
22 GO:0044440 endosomal part 2.828E-3 1.376E-2
7.229E-2
3.026E-1
 3 434
23 GO:0000776 kinetochore 3.124E-3 1.454E-2
7.638E-2
3.343E-1
 2 124
24 GO:0044420 extracellular matrix component 4.018E-3 1.791E-2
9.412E-2
4.299E-1
 2 141
25 GO:0000138 Golgi trans cisterna 4.765E-3 2.039E-2
1.072E-1
5.099E-1
 1 7
26 GO:0000137 Golgi cis cisterna 5.444E-3 2.240E-2
1.177E-1
5.825E-1
 1 8
27 GO:0030426 growth cone 6.600E-3 2.401E-2
1.261E-1
7.062E-1
 2 182
28 GO:0030056 hemidesmosome 6.801E-3 2.401E-2
1.261E-1
7.277E-1
 1 10
29 GO:0005797 Golgi medial cisterna 6.801E-3 2.401E-2
1.261E-1
7.277E-1
 1 10
30 GO:0000775 chromosome, centromeric region 6.812E-3 2.401E-2
1.261E-1
7.289E-1
 2 185
31 GO:0030427 site of polarized growth 6.955E-3 2.401E-2
1.261E-1
7.442E-1
 2 187
32 GO:0005641 nuclear envelope lumen 8.156E-3 2.727E-2
1.433E-1
8.727E-1
 1 12
33 GO:0097449 astrocyte projection 8.833E-3 2.780E-2
1.461E-1
9.451E-1
 1 13
34 GO:0031092 platelet alpha granule membrane 8.833E-3 2.780E-2
1.461E-1
9.451E-1
 1 13
35 GO:0005770 late endosome 9.847E-3 3.010E-2
1.582E-1
1.000E0
 2 224
36 GO:0097386 glial cell projection 1.221E-2 3.629E-2
1.907E-1
1.000E0
 1 18
37 GO:0005640 nuclear outer membrane 1.692E-2 4.894E-2
2.572E-1
1.000E0
 1 25
38 GO:0031904 endosome lumen 1.759E-2 4.954E-2
2.603E-1
1.000E0
 1 26
Show 33 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 166 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011970 Cerebral amyloid angiopathy 9.475E-8 1.573E-5 8.953E-5 1.573E-5 3 11
2 HP:0040154 Acne inversa 5.413E-6 4.493E-4 2.557E-3 8.985E-4 2 4
3 HP:0006979 Sleep-wake cycle disturbance 3.241E-5 1.793E-3 1.021E-2 5.380E-3 2 9
4 HP:0002423 Long-tract signs 7.010E-5 2.909E-3 1.656E-2 1.164E-2 2 13
5 HP:0002511 Alzheimer disease 1.717E-4 4.751E-3 2.704E-2 2.851E-2 3 124
6 HP:0011034 Amyloidosis 1.717E-4 4.751E-3 2.704E-2 2.851E-2 3 124
7 HP:0004968 Recurrent cerebral hemorrhage 1.062E-3 2.519E-2
1.434E-1
1.763E-1
 1 1
8 HP:0002302 Abnormality of cognition 1.465E-3 2.703E-2
1.538E-1
2.432E-1
 3 256
9 HP:0000726 Dementia 1.465E-3 2.703E-2
1.538E-1
2.432E-1
 3 256
10 HP:0002185 Neurofibrillary tangles 1.828E-3 2.938E-2
1.672E-1
3.035E-1
 2 65
11 HP:0004938 Tortuous cerebral arteries 2.124E-3 2.938E-2
1.672E-1
3.525E-1
 1 2
12 HP:0012322 Perifolliculitis 2.124E-3 2.938E-2
1.672E-1
3.525E-1
 1 2
13 HP:0001061 Acne 2.493E-3 2.956E-2
1.683E-1
4.139E-1
 2 76
14 HP:0100578 Lipoatrophy 2.493E-3 2.956E-2
1.683E-1
4.139E-1
 2 76
15 HP:0011132 Chronic furunculosis 3.184E-3 3.524E-2
2.006E-1
5.285E-1
 1 3
16 HP:0100314 Cerebral inclusion bodies 3.874E-3 3.723E-2
2.119E-1
6.431E-1
 2 95
17 HP:0001279 Syncope 3.955E-3 3.723E-2
2.119E-1
6.565E-1
 2 96
18 HP:0009125 Lipodystrophy 4.037E-3 3.723E-2
2.119E-1
6.701E-1
 2 97
Show 13 more annotations

5: Mouse Phenotype [Display Chart] 12 input genes in category / 573 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003354 astrocytosis 2.131E-7 5.487E-5 3.802E-4 1.221E-4 5 130
2 MP:0012065 increased astrocyte number 2.670E-7 5.487E-5 3.802E-4 1.530E-4 5 136
3 MP:0012064 abnormal astrocyte number 2.873E-7 5.487E-5 3.802E-4 1.646E-4 5 138
4 MP:0013380 absent sebocyte 1.231E-6 1.296E-4 8.978E-4 7.055E-4 2 2
5 MP:0008414 abnormal spatial reference memory 1.409E-6 1.296E-4 8.978E-4 8.072E-4 4 78
6 MP:0003871 abnormal myelin sheath morphology 1.560E-6 1.296E-4 8.978E-4 8.938E-4 4 80
7 MP:0002182 abnormal astrocyte morphology 1.770E-6 1.296E-4 8.978E-4 1.014E-3 5 199
8 MP:0008428 abnormal spatial working memory 1.809E-6 1.296E-4 8.978E-4 1.037E-3 4 83
9 MP:0002183 gliosis 3.034E-6 1.923E-4 1.332E-3 1.738E-3 5 222
10 MP:0013379 decreased sebocyte cell number 3.691E-6 1.923E-4 1.332E-3 2.115E-3 2 3
11 MP:0008286 abnormal hippocampus molecular cell layer 3.691E-6 1.923E-4 1.332E-3 2.115E-3 2 3
12 MP:0008415 abnormal neurite morphology 5.824E-6 2.781E-4 1.927E-3 3.337E-3 6 465
13 MP:0009768 impaired somite development 9.594E-6 4.229E-4 2.930E-3 5.497E-3 4 126
14 MP:0004546 esophagus hyperplasia 1.229E-5 5.029E-4 3.485E-3 7.041E-3 2 5
15 MP:0001212 skin lesions 1.376E-5 5.256E-4 3.642E-3 7.884E-3 4 138
16 MP:0013189 abnormal exploration in a new environment 2.348E-5 7.772E-4 5.385E-3 1.346E-2 4 158
17 MP:0000952 abnormal CNS glial cell morphology 2.358E-5 7.772E-4 5.385E-3 1.351E-2 5 338
18 MP:0004251 failure of heart looping 2.545E-5 7.772E-4 5.385E-3 1.458E-2 3 52
19 MP:0013377 abnormal sebocyte number 2.577E-5 7.772E-4 5.385E-3 1.477E-2 2 7
20 MP:0003329 amyloid beta deposits 2.853E-5 8.174E-4 5.664E-3 1.635E-2 3 54
21 MP:0004073 caudal body truncation 3.540E-5 9.659E-4 6.693E-3 2.028E-2 3 58
22 MP:0001690 failure of somite differentiation 4.328E-5 1.127E-3 7.810E-3 2.480E-2 3 62
23 MP:0003400 kinked neural tube 4.541E-5 1.131E-3 7.839E-3 2.602E-2 3 63
24 MP:0000292 distended pericardium 5.712E-5 1.293E-3 8.961E-3 3.273E-2 3 68
25 MP:0001413 abnormal response to new environment 6.037E-5 1.293E-3 8.961E-3 3.459E-2 4 201
26 MP:0000604 amyloidosis 6.231E-5 1.293E-3 8.961E-3 3.570E-2 3 70
27 MP:0003106 abnormal fear-related response 6.502E-5 1.293E-3 8.961E-3 3.725E-2 3 71
28 MP:0008918 microgliosis 6.502E-5 1.293E-3 8.961E-3 3.725E-2 3 71
29 MP:0001411 spinning 6.732E-5 1.293E-3 8.961E-3 3.858E-2 2 11
30 MP:0000920 abnormal myelination 6.771E-5 1.293E-3 8.961E-3 3.880E-2 4 207
31 MP:0002918 abnormal paired-pulse facilitation 7.360E-5 1.360E-3 9.426E-3 4.217E-2 3 74
32 MP:0003634 abnormal glial cell morphology 7.668E-5 1.373E-3 9.514E-3 4.394E-2 5 432
33 MP:0000778 abnormal nervous system tract morphology 8.737E-5 1.477E-3 1.023E-2
5.006E-2
 4 221
34 MP:0014062 nervous system inclusion bodies 8.949E-5 1.477E-3 1.023E-2
5.128E-2
 3 79
35 MP:0005404 abnormal axon morphology 9.530E-5 1.477E-3 1.023E-2
5.461E-2
 4 226
36 MP:0008143 abnormal dendrite morphology 9.530E-5 1.477E-3 1.023E-2
5.461E-2
 4 226
37 MP:0013375 abnormal sebocyte morphology 9.535E-5 1.477E-3 1.023E-2
5.464E-2
 2 13
38 MP:0009936 abnormal dendritic spine morphology 1.000E-4 1.508E-3 1.045E-2
5.731E-2
 3 82
39 MP:0004250 tau protein deposits 1.112E-4 1.589E-3 1.101E-2
6.370E-2
 2 14
40 MP:0004545 enlarged esophagus 1.112E-4 1.589E-3 1.101E-2
6.370E-2
 2 14
41 MP:0001458 abnormal object recognition memory 1.153E-4 1.589E-3 1.101E-2
6.605E-2
 3 86
42 MP:0002207 abnormal long term potentiation 1.165E-4 1.589E-3 1.101E-2
6.675E-2
 4 238
43 MP:0001688 abnormal somite development 1.263E-4 1.683E-3 1.166E-2
7.235E-2
 4 243
44 MP:0001463 abnormal spatial learning 1.388E-4 1.807E-3 1.252E-2
7.951E-2
 4 249
45 MP:0003459 increased fear-related response 1.464E-4 1.864E-3 1.292E-2
8.389E-2
 2 16
46 MP:0003107 abnormal response to novelty 1.924E-4 2.397E-3 1.661E-2
1.103E-1
 4 271
47 MP:0000136 abnormal microglial cell morphology 1.970E-4 2.402E-3 1.664E-2
1.129E-1
 3 103
48 MP:0010138 arteritis 2.082E-4 2.435E-3 1.687E-2
1.193E-1
 2 19
49 MP:0002916 increased synaptic depression 2.082E-4 2.435E-3 1.687E-2
1.193E-1
 2 19
50 MP:0001313 increased incidence of corneal inflammation 2.312E-4 2.598E-3 1.800E-2
1.325E-1
 2 20
Show 45 more annotations

6: Domain [Display Chart] 13 input genes in category / 83 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF10515 APP amyloid Pfam 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
2 PF02177 APP N Pfam 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
3 SM00006 A4 EXTRA SMART 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
4 3.30.1490.140 - Gene3D 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
5 IPR024329 Amyloid glyco E2 domain InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
6 PS00320 A4 INTRA PROSITE 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
7 IPR008154 Amyloid glyco extra InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
8 PF12924 APP Cu bd Pfam 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
9 IPR015849 Amyloid glyco heparin-bd InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
10 3.90.570.10 - Gene3D 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
11 IPR019745 Amyloid glyco intracell CS InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
12 IPR011178 Amyloid glyco Cu-bd InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
13 IPR019543 APP amyloid C InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
14 PF12925 APP E2 Pfam 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
15 PS00319 A4 EXTRA PROSITE 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
16 IPR019744 Amyloid glyco extracell CS InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
17 IPR008155 Amyloid glyco InterPro 2.610E-10 1.274E-9 6.374E-9 2.166E-8 3 3
18 IPR001108 Peptidase A22A InterPro 4.445E-7 1.903E-6 9.518E-6 3.689E-5 2 2
19 PF01080 Presenilin Pfam 4.445E-7 1.903E-6 9.518E-6 3.689E-5 2 2
20 IPR002223 Kunitz BPTI InterPro 4.585E-7 1.903E-6 9.518E-6 3.806E-5 3 23
21 IPR006639 Preselin/SPP InterPro 9.316E-6 3.515E-5 1.758E-4 7.732E-4 2 7
22 SM00730 PSN SMART 9.316E-6 3.515E-5 1.758E-4 7.732E-4 2 7
23 IPR020901 Prtase inh Kunz-CS InterPro 6.758E-5 2.238E-4 1.119E-3 5.609E-3 2 18
24 SM00131 KU SMART 6.758E-5 2.238E-4 1.119E-3 5.609E-3 2 18
25 4.10.410.10 - Gene3D 6.758E-5 2.238E-4 1.119E-3 5.609E-3 2 18
26 PF00014 Kunitz BPTI Pfam 7.550E-5 2.238E-4 1.119E-3 6.266E-3 2 19
27 PS00280 BPTI KUNITZ 1 PROSITE 7.550E-5 2.238E-4 1.119E-3 6.266E-3 2 19
28 PS50279 BPTI KUNITZ 2 PROSITE 7.550E-5 2.238E-4 1.119E-3 6.266E-3 2 19
29 IPR013803 Amyloid glyco Abeta InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
30 PF14959 GSAP-16 Pfam 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
31 4.10.230.10 - Gene3D 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
32 IPR026172 GSAP fam InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
33 IPR001493 Pept A22A PS2 InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
34 IPR002031 Pept A22A PS1 InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
35 IPR028010 GSAP C dom InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
36 PF03494 Beta-APP Pfam 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
37 IPR009120 BACE1 InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
38 IPR028866 APP InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
39 IPR032927 Erbin InterPro 6.939E-4 1.477E-3 7.387E-3
5.759E-2
 1 1
40 IPR033874 Memapsin-like InterPro 1.387E-3 2.559E-3 1.280E-2
1.151E-1
 1 2
41 PF12280 BSMAP Pfam 1.387E-3 2.559E-3 1.280E-2
1.151E-1
 1 2
42 IPR009119 BACE InterPro 1.387E-3 2.559E-3 1.280E-2
1.151E-1
 1 2
43 PF05450 Nicastrin Pfam 1.387E-3 2.559E-3 1.280E-2
1.151E-1
 1 2
44 IPR008710 Nicastrin InterPro 1.387E-3 2.559E-3 1.280E-2
1.151E-1
 1 2
45 IPR022065 Uncharacterised TMEM59 InterPro 1.387E-3 2.559E-3 1.280E-2
1.151E-1
 1 2
46 IPR026914 Calsyntenin InterPro 2.080E-3 3.754E-3 1.878E-2
1.727E-1
 1 3
47 PS00232 CADHERIN 1 PROSITE 2.693E-3 4.525E-3 2.264E-2
2.235E-1
 2 113
48 PF00028 Cadherin Pfam 2.693E-3 4.525E-3 2.264E-2
2.235E-1
 2 113
49 PS50268 CADHERIN 2 PROSITE 2.740E-3 4.525E-3 2.264E-2
2.274E-1
 2 114
50 2.60.40.60 - Gene3D 2.740E-3 4.525E-3 2.264E-2
2.274E-1
 2 114
Show 45 more annotations

7: Pathway [Display Chart] 9 input genes in category / 121 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00003 Alzheimer disease-amyloid secretase pathway PantherDB 4.112E-10 4.975E-8 2.675E-7 4.975E-8 5 65
2 P00004 Alzheimer disease-presenilin pathway PantherDB 6.898E-9 4.173E-7 2.244E-6 8.346E-7 5 113
3 83097 Alzheimer's disease BioSystems: KEGG 5.557E-8 2.241E-6 1.205E-5 6.724E-6 5 171
4 PW:0000015 Alzheimer disease Pathway Ontology 5.247E-7 1.587E-5 8.535E-5 6.349E-5 3 24
5 PW:0000204 Notch signaling Pathway Ontology 1.690E-6 4.043E-5 2.174E-4 2.045E-4 3 35
6 P00045 Notch signaling pathway PantherDB 2.005E-6 4.043E-5 2.174E-4 2.426E-4 3 37
7 83062 Notch signaling pathway BioSystems: KEGG 4.445E-6 7.684E-5 4.132E-4 5.379E-4 3 48
8 138019 p75(NTR)-mediated signaling BioSystems: Pathway Interaction Database 9.206E-6 1.392E-4 7.487E-4 1.114E-3 3 61
9 1269459 Regulated proteolysis of p75NTR BioSystems: REACTOME 2.084E-5 2.801E-4 1.506E-3 2.522E-3 2 10
10 1269542 Signaling by NOTCH4 BioSystems: REACTOME 2.546E-5 2.801E-4 1.506E-3 3.081E-3 2 11
11 1269541 Signaling by NOTCH3 BioSystems: REACTOME 2.546E-5 2.801E-4 1.506E-3 3.081E-3 2 11
12 1269449 NRIF signals cell death from the nucleus BioSystems: REACTOME 4.854E-5 4.894E-4 2.632E-3 5.873E-3 2 15
13 137952 Syndecan-3-mediated signaling events BioSystems: Pathway Interaction Database 6.282E-5 5.847E-4 3.144E-3 7.602E-3 2 17
14 1269539 NOTCH2 Activation and Transmission of Signal to the Nucleus BioSystems: REACTOME 9.686E-5 8.372E-4 4.502E-3 1.172E-2 2 21
15 1269499 Nuclear signaling by ERBB4 BioSystems: REACTOME 1.382E-4 1.115E-3 5.993E-3 1.672E-2 2 25
16 1269536 Activated NOTCH1 Transmits Signal to the Nucleus BioSystems: REACTOME 2.137E-4 1.616E-3 8.689E-3 2.585E-2 2 31
17 1269538 Signaling by NOTCH2 BioSystems: REACTOME 2.424E-4 1.726E-3 9.279E-3 2.934E-2 2 33
18 1269496 Signaling by ERBB4 BioSystems: REACTOME 4.131E-4 2.777E-3 1.493E-2 4.998E-2 2 43
19 137914 Presenilin action in Notch and Wnt signaling BioSystems: Pathway Interaction Database 4.729E-4 3.012E-3 1.620E-2
5.723E-2
 2 46
20 1270334 EPH-ephrin mediated repulsion of cells BioSystems: REACTOME 5.150E-4 3.116E-3 1.676E-2
6.232E-2
 2 48
21 M13968 HIV-I Nef: negative effector of Fas and TNF MSigDB C2 BIOCARTA (v6.0) 7.519E-4 3.499E-3 1.882E-2
9.098E-2
 2 58
22 1268890 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer BioSystems: REACTOME 7.519E-4 3.499E-3 1.882E-2
9.098E-2
 2 58
23 1268891 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants BioSystems: REACTOME 7.519E-4 3.499E-3 1.882E-2
9.098E-2
 2 58
24 1268889 Constitutive Signaling by NOTCH1 PEST Domain Mutants BioSystems: REACTOME 7.519E-4 3.499E-3 1.882E-2
9.098E-2
 2 58
25 1268888 Signaling by NOTCH1 PEST Domain Mutants in Cancer BioSystems: REACTOME 7.519E-4 3.499E-3 1.882E-2
9.098E-2
 2 58
26 1268883 Signaling by NOTCH1 in Cancer BioSystems: REACTOME 7.519E-4 3.499E-3 1.882E-2
9.098E-2
 2 58
27 1269535 Signaling by NOTCH1 BioSystems: REACTOME 1.221E-3 5.473E-3 2.943E-2
1.478E-1
 2 74
28 1269447 Cell death signalling via NRAGE, NRIF and NADE BioSystems: REACTOME 1.356E-3 5.859E-3 3.151E-2
1.641E-1
 2 78
29 PW:0000341 altered Notch signaling involving the macromolecules modifying the main players Pathway Ontology 1.445E-3 6.030E-3 3.243E-2
1.749E-1
 1 2
30 1270330 EPH-Ephrin signaling BioSystems: REACTOME 2.003E-3 8.079E-3 4.344E-2
2.424E-1
 2 95
31 1269445 p75 NTR receptor-mediated signalling BioSystems: REACTOME 2.216E-3 8.651E-3 4.652E-2
2.682E-1
 2 100
32 1269169 Amyloid fiber formation BioSystems: REACTOME 2.305E-3 8.715E-3 4.686E-2
2.789E-1
 2 102
33 1270257 Degradation of the extracellular matrix BioSystems: REACTOME 2.771E-3 1.003E-2
5.396E-2
3.353E-1
 2 112
34 1269530 Signaling by NOTCH BioSystems: REACTOME 2.820E-3 1.003E-2
5.396E-2
3.412E-1
 2 113
35 101143 Neurotrophin signaling pathway BioSystems: KEGG 3.121E-3 1.079E-2
5.803E-2
3.777E-1
 2 119
36 1269367 Platelet degranulation BioSystems: REACTOME 3.825E-3 1.286E-2
6.913E-2
4.629E-1
 2 132
37 1269365 Response to elevated platelet cytosolic Ca2+ BioSystems: REACTOME 4.114E-3 1.345E-2
7.234E-2
4.978E-1
 2 137
38 M599 PAC1 Receptor Pathway MSigDB C2 BIOCARTA (v6.0) 5.050E-3 1.608E-2
8.647E-2
6.111E-1
 1 7
39 1269551 Formyl peptide receptors bind formyl peptides and many other ligands BioSystems: REACTOME 5.770E-3 1.790E-2
9.626E-2
6.982E-1
 1 8
40 M12718 Deregulation of CDK5 in Alzheimers Disease MSigDB C2 BIOCARTA (v6.0) 7.926E-3 2.398E-2
1.289E-1
9.591E-1
 1 11
41 1269254 The NLRP3 inflammasome BioSystems: REACTOME 8.644E-3 2.551E-2
1.372E-1
1.000E0
 1 12
42 1269258 Advanced glycosylation endproduct receptor signaling BioSystems: REACTOME 9.361E-3 2.634E-2
1.416E-1
1.000E0
 1 13
43 1269276 DEx/H-box helicases activate type I IFN and inflammatory cytokines production BioSystems: REACTOME 9.361E-3 2.634E-2
1.416E-1
1.000E0
 1 13
44 M6487 Platelet Amyloid Precursor Protein Pathway MSigDB C2 BIOCARTA (v6.0) 1.008E-2 2.710E-2
1.457E-1
1.000E0
 1 14
45 M16173 Presenilin action in Notch and Wnt signaling MSigDB C2 BIOCARTA (v6.0) 1.008E-2 2.710E-2
1.457E-1
1.000E0
 1 14
46 545328 D-myo-inositol (1,3,4)-trisphosphate biosynthesis BioSystems: BIOCYC 1.079E-2 2.779E-2
1.494E-1
1.000E0
 1 15
47 545332 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) BioSystems: BIOCYC 1.079E-2 2.779E-2
1.494E-1
1.000E0
 1 15
48 1269253 Inflammasomes BioSystems: REACTOME 1.223E-2 3.082E-2
1.657E-1
1.000E0
 1 17
49 MAP00562 Inositol phosphate metabolism MAP00562 Inositol phosphate metabolism GenMAPP 1.366E-2 3.372E-2
1.813E-1
1.000E0
 1 19
50 M16518 Wnt/Ca2+/cyclic GMP signaling. MSigDB C2 BIOCARTA (v6.0) 1.437E-2 3.409E-2
1.833E-1
1.000E0
 1 20
Show 45 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 5482 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17920016 Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Pubmed 3.990E-17 2.188E-13 2.010E-12 2.188E-13 5 7
2 15886206 Spatial segregation of gamma-secretase and substrates in distinct membrane domains. Pubmed 1.064E-16 2.916E-13 2.679E-12 5.832E-13 5 8
3 15146195 Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Pubmed 2.077E-15 3.796E-12 3.487E-11 1.139E-11 6 42
4 22045484 The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress. Pubmed 8.066E-15 5.527E-12 5.078E-11 4.422E-11 4 4
5 17556541 Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Pubmed 8.066E-15 5.527E-12 5.078E-11 4.422E-11 4 4
6 19457123 Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity. Pubmed 8.066E-15 5.527E-12 5.078E-11 4.422E-11 4 4
7 22170863 β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. Pubmed 8.066E-15 5.527E-12 5.078E-11 4.422E-11 4 4
8 10993067 Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Pubmed 8.066E-15 5.527E-12 5.078E-11 4.422E-11 4 4
9 16423463 Genetic study of Sardinian patients with Alzheimer's disease. Pubmed 4.032E-14 2.210E-11 2.031E-10 2.210E-10 4 5
10 20811458 Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Pubmed 4.032E-14 2.210E-11 2.031E-10 2.210E-10 4 5
11 22074918 Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. Pubmed 1.209E-13 5.100E-11 4.685E-10 6.630E-10 4 6
12 14717705 Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations. Pubmed 1.209E-13 5.100E-11 4.685E-10 6.630E-10 4 6
13 14699153 Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. Pubmed 1.209E-13 5.100E-11 4.685E-10 6.630E-10 4 6
14 19005074 Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. Pubmed 2.821E-13 1.031E-10 9.473E-10 1.547E-9 4 7
15 24145027 Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. Pubmed 2.821E-13 1.031E-10 9.473E-10 1.547E-9 4 7
16 25741723 Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Pubmed 3.987E-12 1.366E-9 1.255E-8 2.185E-8 4 12
17 20009122 [Genetics of dementias, Part 4: a spectrum of mutations responsible for the familial autosomal dominant form of Alzheimer's disease]. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
18 16103123 Gamma-secretase is a functional component of phagosomes. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
19 19494151 Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
20 25998117 Genetic testing and counseling in the diagnosis and management of young-onset dementias. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
21 11568920 Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
22 15345711 Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
23 22312439 Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
24 11050115 Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
25 24630972 Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
26 29018038 Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
27 8922407 Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
28 15561424 Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
29 20693289 Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
30 12388777 Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
31 12048259 Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
32 23345401 APLP2 regulates neuronal stem cell differentiation during cortical development. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
33 10356989 Transgenic animals in Alzheimer's disease research. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
34 24650794 Mutational analysis in early-onset familial Alzheimer's disease in Mainland China. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
35 20594621 The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
36 16193067 Homo- and heterodimerization of APP family members promotes intercellular adhesion. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
37 18667258 Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
38 15776278 Novel mutations and repeated findings of mutations in familial Alzheimer disease. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
39 17268504 When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
40 17412506 A mutation screening by DHPLC of PSEN1 and APP genes reveals no significant variation associated with the sporadic late-onset form of Alzheimer's disease. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
41 26337232 A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
42 15951428 Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
43 21959359 Molecular genetic analysis of the APP, PSEN1, and PSEN2 genes in Finnish patients with early-onset Alzheimer disease and frontotemporal lobar degeneration. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
44 23815291 Amyloid precursor proteins are constituents of the presynaptic active zone. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
45 16889988 Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
46 10537029 Progress toward valid transgenic mouse models for Alzheimer's disease. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
47 20008660 High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
48 20724034 Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
49 27135718 Genomics of Alzheimer Disease: A Review. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
50 24998676 Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Pubmed 3.080E-11 3.186E-9 2.927E-8 1.689E-7 3 3
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 2553 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PSEN1 PSEN1 interactions 7.627E-13 1.947E-9 1.640E-8 1.947E-9 7 117
2 int:GSAP GSAP interactions 2.619E-12 3.344E-9 2.816E-8 6.688E-9 4 6
3 int:PSENEN PSENEN interactions 5.751E-11 4.894E-8 4.122E-7 1.468E-7 4 11
4 int:NCSTN NCSTN interactions 4.644E-10 2.964E-7 2.496E-6 1.186E-6 6 146
5 int:BACE1 BACE1 interactions 5.439E-9 2.777E-6 2.339E-5 1.389E-5 4 31
6 int:APBA3 APBA3 interactions 1.574E-8 6.697E-6 5.641E-5 4.018E-5 4 40
7 int:APH1B APH1B interactions 2.091E-7 6.404E-5 5.393E-4 5.339E-4 3 17
8 int:KCNIP4 KCNIP4 interactions 2.091E-7 6.404E-5 5.393E-4 5.339E-4 3 17
9 int:PSEN2 PSEN2 interactions 2.296E-7 6.404E-5 5.393E-4 5.861E-4 4 77
10 int:CPEB1 CPEB1 interactions 2.508E-7 6.404E-5 5.393E-4 6.404E-4 3 18
11 int:APBA1 APBA1 interactions 5.432E-7 1.261E-4 1.062E-3 1.387E-3 3 23
12 int:APBB1 APBB1 interactions 6.076E-7 1.293E-4 1.089E-3 1.551E-3 4 98
13 int:APBB3 APBB3 interactions 7.965E-7 1.564E-4 1.317E-3 2.033E-3 3 26
14 int:CTNND2 CTNND2 interactions 1.003E-6 1.829E-4 1.540E-3 2.560E-3 3 28
15 int:PRNP PRNP interactions 1.196E-6 2.035E-4 1.714E-3 3.052E-3 4 116
16 int:APBA2 APBA2 interactions 1.374E-6 2.193E-4 1.847E-3 3.508E-3 3 31
17 int:APH1A APH1A interactions 1.516E-6 2.276E-4 1.917E-3 3.869E-3 3 32
18 int:APBB2 APBB2 interactions 2.178E-6 3.024E-4 2.547E-3 5.561E-3 3 36
19 int:CLSTN1 CLSTN1 interactions 2.369E-6 3.024E-4 2.547E-3 6.049E-3 3 37
20 int:HERPUD1 HERPUD1 interactions 2.369E-6 3.024E-4 2.547E-3 6.049E-3 3 37
21 int:RNF32 RNF32 interactions 3.753E-6 4.563E-4 3.843E-3 9.583E-3 3 43
22 int:CASP6 CASP6 interactions 4.026E-6 4.672E-4 3.935E-3 1.028E-2 3 44
23 int:NOS3 NOS3 interactions 7.939E-6 8.812E-4 7.422E-3 2.027E-2 3 55
24 int:ALOX5 ALOX5 interactions 1.033E-5 1.065E-3 8.973E-3 2.638E-2 3 60
25 int:CHKA CHKA interactions 1.043E-5 1.065E-3 8.973E-3 2.663E-2 2 7
26 int:FGF13 FGF13 interactions 1.390E-5 1.365E-3 1.150E-2 3.550E-2 2 8
27 int:DOCK3 DOCK3 interactions 2.728E-5 2.579E-3 2.172E-2
6.964E-2
 2 11
28 int:DAB1 DAB1 interactions 2.848E-5 2.597E-3 2.187E-2
7.271E-2
 3 84
29 int:DAB2 DAB2 interactions 3.387E-5 2.982E-3 2.512E-2
8.648E-2
 3 89
30 int:CTNND1 CTNND1 interactions 3.990E-5 3.395E-3 2.860E-2
1.019E-1
 3 94
31 int:CSNK1D CSNK1D interactions 4.659E-5 3.837E-3 3.231E-2
1.189E-1
 3 99
32 int:GFAP GFAP interactions 4.945E-5 3.946E-3 3.323E-2
1.263E-1
 3 101
33 int:EEPD1 EEPD1 interactions 5.199E-5 4.022E-3 3.388E-2
1.327E-1
 2 15
34 int:NOTCH4 NOTCH4 interactions 5.939E-5 4.460E-3 3.756E-2
1.516E-1
 2 16
35 int:UTP14A UTP14A interactions 7.284E-5 5.290E-3 4.456E-2
1.860E-1
 3 115
36 int:METTL2A METTL2A interactions 7.566E-5 5.290E-3 4.456E-2
1.932E-1
 2 18
37 int:ECSIT ECSIT interactions 7.667E-5 5.290E-3 4.456E-2
1.957E-1
 3 117
38 int:IL20RB IL20RB interactions 8.453E-5 5.679E-3 4.783E-2
2.158E-1
 2 19
39 int:ICAM5 ICAM5 interactions 9.388E-5 6.145E-3
5.176E-2
2.397E-1
 2 20
40 int:ABR ABR interactions 1.037E-4 6.458E-3
5.440E-2
2.648E-1
 2 21
41 int:KLK2 KLK2 interactions 1.037E-4 6.458E-3
5.440E-2
2.648E-1
 2 21
42 int:SHOC2 SHOC2 interactions 1.140E-4 6.932E-3
5.839E-2
2.912E-1
 2 22
43 int:GCDH GCDH interactions 1.249E-4 7.244E-3
6.101E-2
3.187E-1
 2 23
44 int:KCNIP3 KCNIP3 interactions 1.249E-4 7.244E-3
6.101E-2
3.187E-1
 2 23
45 int:DEDD DEDD interactions 1.361E-4 7.724E-3
6.506E-2
3.476E-1
 2 24
46 int:CIB1 CIB1 interactions 1.729E-4 9.597E-3
8.083E-2
4.415E-1
 2 27
47 int:LRRC1 LRRC1 interactions 1.862E-4 1.011E-2
8.516E-2
4.752E-1
 2 28
48 int:RYR2 RYR2 interactions 1.999E-4 1.063E-2
8.953E-2
5.102E-1
 2 29
49 int:HOXC4 HOXC4 interactions 2.287E-4 1.168E-2
9.836E-2
5.839E-1
 2 31
50 int:PRAM1 PRAM1 interactions 2.287E-4 1.168E-2
9.836E-2
5.839E-1
 2 31
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q23.2-q23.3 11q23.2-q23.3 3.751E-4 4.875E-3 1.550E-2 4.876E-3 1 1
2 1q31-q42 1q31-q42 7.500E-4 4.875E-3 1.550E-2 9.750E-3 1 2
3 1q22-q23 1q22-q23 4.866E-3 1.750E-2
5.566E-2
6.325E-2
 1 13
4 11q24 11q24 6.358E-3 1.750E-2
5.566E-2
8.266E-2
 1 17
5 5q12.3 5q12.3 6.731E-3 1.750E-2
5.566E-2
8.751E-2
 1 18
6 21q21.3 21q21.3 8.594E-3 1.862E-2
5.921E-2
1.117E-1
 1 23
7 1p36.22 1p36.22 1.453E-2 2.657E-2
8.449E-2
1.889E-1
 1 39
8 16q21 16q21 1.712E-2 2.657E-2
8.449E-2
2.225E-1
 1 46
9 1q42.13 1q42.13 2.007E-2 2.657E-2
8.449E-2
2.609E-1
 1 54
10 19q13.1 19q13.1 2.044E-2 2.657E-2
8.449E-2
2.657E-1
 1 55
11 1p32.3 1p32.3 2.264E-2 2.676E-2
8.510E-2
2.944E-1
 1 61
12 14q24.3 14q24.3 3.506E-2 3.796E-2
1.207E-1
4.557E-1
 1 95
13 7q11.23 7q11.23 3.796E-2 3.796E-2
1.207E-1
4.934E-1
 1 103
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 11 input genes in category / 91 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1186 CD molecules|Type II classical cadherins genenames.org 2.855E-3 7.465E-3 1.555E-2 1.142E-2 1 13
2 24 Cadherin related genenames.org 3.733E-3 7.465E-3 1.555E-2 1.493E-2 1 17
3 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 3.300E-2 4.401E-2
9.168E-2
1.320E-1
 1 152

13: Coexpression [Display Chart] 13 input genes in category / 1694 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12925741-Figure13 Human Lymphoma Jenner03 15genes GeneSigDB 1.598E-5 1.522E-2
1.220E-1
 2.707E-2 2 11
2 19038878-SuppTable3 Human Leukemia Lenz08 385genes GeneSigDB 3.267E-5 1.522E-2
1.220E-1
5.535E-2
 4 349
3 15388584-Table5 Human BoneMarrow Abraham05 20genes GeneSigDB 4.436E-5 1.522E-2
1.220E-1
7.515E-2
 2 18
4 M9880 Genes down-regulated in immunoglobulin light chain amyloidosis plasma cells (ALPC) compared to multiple myeloma (MM) cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.957E-5 1.522E-2
1.220E-1
8.396E-2
 2 19
5 15361835-Table1 Human StemCell Gelman04 26genes GeneSigDB 8.679E-5 1.522E-2
1.220E-1
1.470E-1
 2 25
6 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v6.0) 8.986E-5 1.522E-2
1.220E-1
1.522E-1
 3 161
7 15377468-Table3 Human Leukemia Lindvall04 30genes HigherExpression GeneSigDB 1.173E-4 1.522E-2
1.220E-1
1.987E-1
 2 29
8 M1384 Cluster 2 of genes distinguishing among different B lymphocyte neoplasms. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.257E-4 1.522E-2
1.220E-1
2.129E-1
 2 30
9 M11850 Genes up-regulated in WI-38 cells (senescent primary fibroblasts) after inactivation of TP53 [GeneID=7157] by GSE56 polypeptide. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.524E-4 1.522E-2
1.220E-1
2.581E-1
 2 33
10 M4719 Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.633E-4 1.522E-2
1.220E-1
2.766E-1
 3 197
11 M4729 Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulatd with R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.657E-4 1.522E-2
1.220E-1
2.807E-1
 3 198
12 M6843 Genes down-regulated in CD4 [GeneID=920] T cells from lymph nodes: naïve versus day 28 after immunization. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.522E-2
1.220E-1
2.849E-1
 3 199
13 M8351 Genes up-regulated in atherosclerosis macrophages: anti miR-33 versus untreated. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.522E-2
1.220E-1
2.849E-1
 3 199
14 M7259 Genes up-regulated in thymus perimedullary cortical region versus the whole medulla. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.522E-2
1.220E-1
2.849E-1
 3 199
15 M4526 Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.522E-2
1.220E-1
2.849E-1
 3 199
16 M5167 Genes down-regulated in comparison of macrophages versus macrophages exposed to B. malayi (50 worms/well). MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.522E-2
1.220E-1
2.892E-1
 3 200
17 M4297 Genes up-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] low T cells at. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.522E-2
1.220E-1
2.892E-1
 3 200
18 M5072 Genes up-regulated in comparison of memory CD8 T cells versus naive CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.522E-2
1.220E-1
2.892E-1
 3 200
19 M4492 Genes down-regulated in comparison of naive CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.522E-2
1.220E-1
2.892E-1
 3 200
20 12941627-table1b Mouse StemCell Karsten03 39genes GeneSigDB 1.816E-4 1.538E-2
1.233E-1
3.077E-1
 2 36
21 16518402-SuppTable3 Human Breast Adler06 39genes GeneSigDB 2.134E-4 1.722E-2
1.379E-1
3.615E-1
 2 39
22 M5895 Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. MSigDB H: Hallmark Gene Sets (v6.0) 2.478E-4 1.908E-2
1.529E-1
4.197E-1
 2 42
23 M1551 Genes whose splicing in neocortex was most affected by knock out of NOVA2 [GeneID=4858]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.598E-4 1.913E-2
1.533E-1
4.400E-1
 2 43
24 M18513 Top 50 up-regulated genes in cluster CD-2 of multiple myeloma samples with the characteristic expression spike of CCND3 [GeneID=896]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.846E-4 1.928E-2
1.545E-1
4.821E-1
 2 45
25 15300801-Table2 Human Breast Nagai04 52genes ERneg GeneSigDB 2.846E-4 1.928E-2
1.545E-1
4.821E-1
 2 45
26 15150091-Table4 Human Viral Schaefer04 56genes GeneSigDB 4.412E-4 2.874E-2
2.303E-1
7.474E-1
 2 56
27 M3063 Genes down-regulated in HEK293 cells (embryonic kidney) at 6 h, 12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.926E-4 3.064E-2
2.455E-1
8.345E-1
 3 287
28 12925741-Figure3 Human Lymphoma Jenner03 75genes GeneSigDB 5.064E-4 3.064E-2
2.455E-1
8.579E-1
 2 60
29 M1685 Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MHS stroma cells (macrophages). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.327E-4 4.864E-2
3.897E-1
1.000E0
 2 77
30 20460173-ImmPortCentrocytevsNaive Human Immune Kong10 109genes ImmPort CentrocytevsNaive GeneSigDB 9.209E-4 4.970E-2
3.982E-1
1.000E0
 2 81
31 M1885 Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.980E-4 4.970E-2
3.982E-1
1.000E0
 3 366
32 11731795-SuppTable1 Human Lymphoma Armstrong02 100genes UnderExpressed GeneSigDB 1.037E-3 4.970E-2
3.982E-1
1.000E0
 2 86
33 16249385-Table2 Human Leukemia Ge06 105genes GeneSigDB 1.037E-3 4.970E-2
3.982E-1
1.000E0
 2 86
34 17346539-Table2 Human Ovarian Bignotti07 126genes MetsvPrimary up GeneSigDB 1.061E-3 4.970E-2
3.982E-1
1.000E0
 2 87
35 M2761 Top 100 probe sets contrubuting to the positive side of the 2nd principal component; associated with adipocytic differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.061E-3 4.970E-2
3.982E-1
1.000E0
 2 87
36 15930281-Table1 Human BoneMarrow HuLieskovan05 107genes GeneSigDB 1.086E-3 4.970E-2
3.982E-1
1.000E0
 2 88
37 M18322 Genes up-regulated in RD-EF cells (rhabdomyosarcoma) engineered to express EWSR1-FLI1 fusion [GeneID=2130;2313] and which are also highly expressed in Ewing's famliy tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.086E-3 4.970E-2
3.982E-1
1.000E0
 2 88
Show 32 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 1383 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Pdgfa,Pik3r3 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Pdgfa,Pik3r3 BrainMap 3.898E-6 5.391E-3 4.210E-2 5.391E-3 4 192
2 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s4 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s4 Top 200 Genes StanfordMouse+HumanSingleCells 5.309E-5 1.599E-2
1.249E-1
7.342E-2
 4 373
3 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 gudmap RNAseq p2 Glomerlular Endothelial 2500 K4 Gudmap RNAseq 6.440E-5 1.599E-2
1.249E-1
8.907E-2
 4 392
4 GSM605811 500 gamma delta T cells, Tgd.vg5-.IEL, CD8a+ CD8b- TCRgd+ Vg5- CD44lo, Small Intestine, avg-3 Immgen.org, GSE15907 7.310E-5 1.599E-2
1.249E-1
1.011E-1
 4 405
5 gudmap kidney adult Podocyte MafB k2 1000 kidney adult Podocyte MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.348E-5 1.599E-2
1.249E-1
1.016E-1
 3 142
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal RCC IF-U/Kidney Normal RCC IF16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal RCC IF-U/Kidney Normal RCC IF16 Adult, Development, and Cancer types 1.210E-4 1.599E-2
1.249E-1
1.673E-1
 3 168
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R14 Adult, Development, and Cancer types 1.484E-4 1.599E-2
1.249E-1
2.052E-1
 3 180
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK14 Adult, Development, and Cancer types 1.508E-4 1.599E-2
1.249E-1
2.086E-1
 3 181
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R14 Adult, Development, and Cancer types 1.508E-4 1.599E-2
1.249E-1
2.086E-1
 3 181
10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Medulla Wilms PT-U/Kidney Normal-Medulla Wilms PT16 Adult, Development, and Cancer types 1.533E-4 1.599E-2
1.249E-1
2.120E-1
 3 182
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Tumour PapRCC Ureter epithelium/Kidney Tumour PapRCC N15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Tumour PapRCC Ureter epithelium/Kidney Tumour PapRCC N15 Adult, Development, and Cancer types 1.609E-4 1.599E-2
1.249E-1
2.225E-1
 3 185
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour PapRCC Mast cell/Kidney Tumour PapRCC IN15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour PapRCC Mast cell/Kidney Tumour PapRCC IN15 Adult, Development, and Cancer types 1.661E-4 1.599E-2
1.249E-1
2.297E-1
 3 187
13 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Trf BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Trf BrainMap 1.741E-4 1.599E-2
1.249E-1
2.408E-1
 3 190
14 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/endocardial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/endocardial cell Tabula Muris Consortium 1.768E-4 1.599E-2
1.249E-1
2.445E-1
 3 191
15 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid Tabula Muris Consortium 1.823E-4 1.599E-2
1.249E-1
2.521E-1
 3 193
16 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 1.966E-4 1.599E-2
1.249E-1
2.719E-1
 3 198
17 Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes 1.966E-4 1.599E-2
1.249E-1
2.719E-1
 3 198
18 Lungmap Mouse Lung PND1 Immune Subtype Macrophages-A Lungmap Mouse Lung PND1 Immune Subtype Macrophages-A Lungmap CCHMC 2.753E-4 2.115E-2
1.652E-1
3.807E-1
 3 222
19 Lungmap Mouse Lung PND3 Epithelial Subtype AT1 Lungmap Mouse Lung PND3 Epithelial Subtype AT1 Lungmap CCHMC 4.373E-4 3.183E-2
2.486E-1
6.048E-1
 3 260
20 gudmap RNAseq e15.5 Endothelial 2500 K4 gudmap RNAseq e15.5 Endothelial 2500 K4 Gudmap RNAseq 5.716E-4 3.953E-2
3.087E-1
7.905E-1
 3 285
21 Facebase RNAseq e10.5 Olfactory Pit 2500 K1 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 6.320E-4 4.147E-2
3.239E-1
8.740E-1
 3 295
22 gudmap kidney P4 CapMesRenVes Crym k1 1000 kidney P4 CapMesRenVes Crym k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.667E-4 4.147E-2
3.239E-1
9.221E-1
 2 65
23 BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Excitatory Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Excitatory Top 200 Genes BrainMap 6.897E-4 4.147E-2
3.239E-1
9.538E-1
 3 304
24 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eRgl Subtype eRgle Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eRgl Subtype eRgle Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 8.446E-4 4.785E-2
3.737E-1
1.000E0
 3 326
25 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb2 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb2 Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 8.750E-4 4.785E-2
3.737E-1
1.000E0
 3 330
26 Facebase RNAseq ratio e10.5 MaxillaryArch vs Mandibular 2500 K4 FacebaseRNAseq ratio e10.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 2500 k-means-cluster#4 FaceBase_RNAseq 9.060E-4 4.785E-2
3.737E-1
1.000E0
 3 334
27 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAb Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAb Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 9.341E-4 4.785E-2
3.737E-1
1.000E0
 2 77
28 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hDA Subtype hDA2 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hDA Subtype hDA2 Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 9.867E-4 4.874E-2
3.806E-1
1.000E0
 3 344
Show 23 more annotations

15: Computational [Display Chart] 13 input genes in category / 68 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 13 input genes in category / 625 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 1.036E-5 4.741E-3 3.326E-2 6.474E-3 3 242
2 hsa-miR-1260b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.517E-5 4.741E-3 3.326E-2 9.482E-3 3 275
3 hsa-miR-183-5p:Functional MTI Functional MTI miRTarbase 3.137E-5 6.536E-3 4.585E-2 1.961E-2 3 351
4 hsa-miR-941:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.415E-5 6.899E-3 4.840E-2 2.760E-2 2 55
5 hsa-miR-1914*:mirSVR highEffct hsa-miR-1914*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.789E-5 8.214E-3
5.763E-2
 4.868E-2 3 477
6 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 7.886E-5 8.214E-3
5.763E-2
 4.928E-2 3 479
7 hsa-miR-6073:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.322E-4 1.122E-2
7.870E-2
8.264E-2
 2 95
8 hsa-miR-455-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.436E-4 1.122E-2
7.870E-2
8.974E-2
 2 99
9 hsa-miR-224-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.904E-4 1.211E-2
8.494E-2
1.190E-1
 2 114
10 hsa-miR-522-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.937E-4 1.211E-2
8.494E-2
1.211E-1
 2 115
11 hsa-miR-133a-3p:Functional MTI Functional MTI miRTarbase 2.474E-4 1.328E-2
9.320E-2
1.546E-1
 2 130
12 hsa-miR-328-3p:Functional MTI Functional MTI miRTarbase 2.551E-4 1.328E-2
9.320E-2
1.594E-1
 2 132
13 hsa-miR-193a-3p:PITA hsa-miR-193a-3p:PITA TOP PITA 2.992E-4 1.354E-2
9.502E-2
1.870E-1
 2 143
14 hsa-miR-193b:PITA hsa-miR-193b:PITA TOP PITA 3.034E-4 1.354E-2
9.502E-2
1.896E-1
 2 144
15 hsa-miR-503:mirSVR highEffct hsa-miR-503:mirSVR conserved highEffect-0.5 MicroRNA.org 3.513E-4 1.415E-2
9.926E-2
2.195E-1
 2 155
16 hsa-miR-487b:mirSVR highEffct hsa-miR-487b:mirSVR conserved highEffect-0.5 MicroRNA.org 3.835E-4 1.415E-2
9.926E-2
2.397E-1
 2 162
17 hsa-miR-298:Functional MTI Functional MTI miRTarbase 3.978E-4 1.415E-2
9.926E-2
2.486E-1
 2 165
18 hsa-miR-660:PITA hsa-miR-660:PITA TOP PITA 4.075E-4 1.415E-2
9.926E-2
2.547E-1
 2 167
19 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 5.947E-4 1.698E-2
1.191E-1
3.717E-1
 2 202
20 hsa-miR-658:mirSVR highEffct hsa-miR-658:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.005E-4 1.698E-2
1.191E-1
3.753E-1
 2 203
21 hsa-miR-193b-3p:TargetScan hsa-miR-193b-3p TargetScan 6.484E-4 1.698E-2
1.191E-1
4.052E-1
 2 211
22 hsa-miR-193a-3p:TargetScan hsa-miR-193a-3p TargetScan 6.484E-4 1.698E-2
1.191E-1
4.052E-1
 2 211
23 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 6.668E-4 1.698E-2
1.191E-1
4.167E-1
 2 214
24 hsa-miR-335-5p:TargetScan hsa-miR-335-5p TargetScan 6.730E-4 1.698E-2
1.191E-1
4.206E-1
 2 215
25 hsa-miR-4698:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.792E-4 1.698E-2
1.191E-1
4.245E-1
 2 216
26 hsa-miR-339-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.027E-4 1.921E-2
1.348E-1
5.017E-1
 2 235
27 hsa-miR-874-3p:TargetScan hsa-miR-874-3p TargetScan 8.300E-4 1.921E-2
1.348E-1
5.187E-1
 2 239
28 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 9.954E-4 2.044E-2
1.434E-1
6.222E-1
 2 262
29 hsa-miR-183:PITA hsa-miR-183:PITA TOP PITA 1.018E-3 2.044E-2
1.434E-1
6.363E-1
 2 265
30 hsa-miR-4786-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.026E-3 2.044E-2
1.434E-1
6.411E-1
 2 266
31 hsa-miR-93-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.049E-3 2.044E-2
1.434E-1
6.554E-1
 2 269
32 hsa-miR-634:PITA hsa-miR-634:PITA TOP PITA 1.072E-3 2.044E-2
1.434E-1
6.700E-1
 2 272
33 TCGATGG,MIR-213:MSigDB TCGATGG,MIR-213:MSigDB MSigDB 1.079E-3 2.044E-2
1.434E-1
6.745E-1
 1 6
34 hsa-miR-140-5p:PITA hsa-miR-140-5p:PITA TOP PITA 1.159E-3 2.071E-2
1.453E-1
7.245E-1
 2 283
35 CAGTGTT,MIR-141:MSigDB CAGTGTT,MIR-141:MSigDB MSigDB 1.225E-3 2.071E-2
1.453E-1
7.655E-1
 2 291
36 CAGTGTT,MIR-200A:MSigDB CAGTGTT,MIR-200A:MSigDB MSigDB 1.225E-3 2.071E-2
1.453E-1
7.655E-1
 2 291
37 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 1.250E-3 2.071E-2
1.453E-1
7.812E-1
 2 294
38 hsa-miR-376c:PITA hsa-miR-376c:PITA TOP PITA 1.284E-3 2.071E-2
1.453E-1
8.023E-1
 2 298
39 hsa-miR-140-5p:TargetScan hsa-miR-140-5p TargetScan 1.292E-3 2.071E-2
1.453E-1
8.076E-1
 2 299
40 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 1.468E-3 2.253E-2
1.581E-1
9.176E-1
 2 319
41 hsa-miR-3672:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.514E-3 2.253E-2
1.581E-1
9.462E-1
 2 324
42 hsa-miR-6864-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.514E-3 2.253E-2
1.581E-1
9.462E-1
 2 324
43 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 1.694E-3 2.462E-2
1.727E-1
1.000E0
 2 343
44 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 1.792E-3 2.546E-2
1.786E-1
1.000E0
 2 353
45 hsa-miR-323a-3p:TargetScan hsa-miR-323a-3p TargetScan 1.883E-3 2.615E-2
1.835E-1
1.000E0
 2 362
46 hsa-miR-125b-1*:mirSVR lowEffct hsa-miR-125b-1*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.040E-3 2.771E-2
1.944E-1
1.000E0
 2 377
47 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 2.115E-3 2.782E-2
1.952E-1
1.000E0
 2 384
48 hsa-miR-922:PITA hsa-miR-922:PITA TOP PITA 2.136E-3 2.782E-2
1.952E-1
1.000E0
 2 386
49 hsa-miR-3193:mirSVR lowEffct hsa-miR-3193:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.213E-3 2.798E-2
1.963E-1
1.000E0
 2 393
50 hsa-miR-130a-3p:Functional MTI Functional MTI miRTarbase 2.269E-3 2.798E-2
1.963E-1
1.000E0
 2 398
Show 45 more annotations

17: Drug [Display Chart] 13 input genes in category / 4479 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005479484 hydroxyethylene dipeptide isostere Stitch 4.017E-18 1.799E-14 1.617E-13 1.799E-14 6 11
2 CID000024403 TSPP Stitch 6.976E-16 1.562E-12 1.404E-11 3.124E-12 7 57
3 CID000122145 CHAPSO Stitch 1.235E-11 1.845E-8 1.657E-7 5.534E-8 5 38
4 CID000018995 Exiproben Stitch 3.114E-11 3.487E-8 3.133E-7 1.395E-7 4 12
5 CID000453015 AC1L9QP0 Stitch 4.496E-11 3.880E-8 3.486E-7 2.014E-7 4 13
6 CID000003849 AC1L1GUQ Stitch 5.197E-11 3.880E-8 3.486E-7 2.328E-7 5 50
7 CID000003394 flurbiprofen Stitch 2.649E-10 1.695E-7 1.523E-6 1.187E-6 6 171
8 CID000005184 scopolamine Stitch 6.817E-10 3.817E-7 3.429E-6 3.053E-6 6 200
9 CID000002788 clioquinol Stitch 3.534E-9 1.759E-6 1.580E-5 1.583E-5 5 114
10 CID000001301 MNPA Stitch 5.188E-9 2.320E-6 2.085E-5 2.324E-5 5 123
11 CID000022251 thioflavin Stitch 5.698E-9 2.320E-6 2.085E-5 2.552E-5 4 40
12 CID000003672 ibuprofen Stitch 6.875E-9 2.566E-6 2.306E-5 3.079E-5 6 294
13 CID000001935 tacrine Stitch 1.148E-8 3.955E-6 3.553E-5 5.141E-5 5 144
14 CID005326889 AC1NS19J Stitch 1.682E-8 5.380E-6 4.834E-5 7.532E-5 4 52
15 CID000000703 flavin adenine dinucleotide sodium Stitch 2.151E-8 6.423E-6 5.771E-5 9.634E-5 6 356
16 CID009827273 TAPI-1 Stitch 2.450E-8 6.858E-6 6.161E-5 1.097E-4 4 57
17 ctd:D004050 Ditiocarb CTD 2.630E-8 6.930E-6 6.226E-5 1.178E-4 4 58
18 CID000004742 NSC272671 Stitch 2.967E-8 7.382E-6 6.633E-5 1.329E-4 5 174
19 CID000002956 A25152 Stitch 3.454E-8 8.143E-6 7.316E-5 1.547E-4 4 62
20 CID000324966 Nortryptoquivaline Stitch 3.687E-8 8.257E-6 7.419E-5 1.651E-4 4 63
21 CID000456427 AC1L9UW6 Stitch 4.106E-8 8.358E-6 7.510E-5 1.839E-4 3 13
22 CID000060874 NSC 670881 Stitch 4.106E-8 8.358E-6 7.510E-5 1.839E-4 3 13
23 ctd:C004479 pimagedine CTD 4.738E-8 9.228E-6 8.291E-5 2.122E-4 4 67
24 CID000130300 paramethoxyphenyl-acetyl dehydroalanine Stitch 5.341E-8 9.640E-6 8.661E-5 2.392E-4 4 69
25 CID000001335 4-dideoxy-1,4-imino-D-xylitol Stitch 5.381E-8 9.640E-6 8.661E-5 2.410E-4 5 196
26 CID000001263 AC1L1B35 Stitch 7.098E-8 1.223E-5 1.099E-4 3.179E-4 4 74
27 CID000068876 cloricromene Stitch 1.367E-7 2.073E-5 1.862E-4 6.125E-4 4 87
28 CID003035605 HAHs Stitch 1.388E-7 2.073E-5 1.862E-4 6.218E-4 3 19
29 CID000053657 P-F-H Stitch 1.388E-7 2.073E-5 1.862E-4 6.218E-4 3 19
30 CID000192706 phenserine Stitch 1.388E-7 2.073E-5 1.862E-4 6.218E-4 3 19
31 ctd:D012435 S-Adenosylhomocysteine CTD 1.633E-7 2.359E-5 2.119E-4 7.313E-4 3 20
32 CID000448381 2hqu Stitch 1.703E-7 2.384E-5 2.141E-4 7.627E-4 5 247
33 CID000005352 aflodac Stitch 2.698E-7 3.525E-5 3.167E-4 1.208E-3 5 271
34 ctd:D007530 Isoflurane CTD 2.920E-7 3.525E-5 3.167E-4 1.308E-3 4 105
35 ctd:C495708 N-benzyloxycarbonyl-valyl-leucyl-leucinal CTD 2.990E-7 3.525E-5 3.167E-4 1.339E-3 2 2
36 CID003033995 S-182 Stitch 2.990E-7 3.525E-5 3.167E-4 1.339E-3 2 2
37 ctd:C584427 2-amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro(imidazole-4,1'-naphthalen)-5(1H)-one CTD 2.990E-7 3.525E-5 3.167E-4 1.339E-3 2 2
38 ctd:C584426 GNE-629 CTD 2.990E-7 3.525E-5 3.167E-4 1.339E-3 2 2
39 CID000073551 Ad41 Stitch 3.289E-7 3.777E-5 3.393E-4 1.473E-3 3 25
40 ctd:D015240 Phorbol 12,13-Dibutyrate CTD 4.180E-7 4.680E-5 4.205E-4 1.872E-3 3 27
41 CID000415676 NSC71948 Stitch 8.743E-7 9.129E-5 8.202E-4 3.916E-3 4 138
42 ctd:C521476 memoquin CTD 8.968E-7 9.129E-5 8.202E-4 4.017E-3 2 3
43 CID000206031 Om 99-2 Stitch 8.968E-7 9.129E-5 8.202E-4 4.017E-3 2 3
44 ctd:C484278 N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide CTD 8.968E-7 9.129E-5 8.202E-4 4.017E-3 2 3
45 CID000447564 Ph-F Stitch 1.036E-6 1.032E-4 9.269E-4 4.642E-3 4 144
46 CID000068108 isocoumarin Stitch 1.301E-6 1.267E-4 1.138E-3 5.826E-3 3 39
47 CID000073665 prochloraz Stitch 1.391E-6 1.325E-4 1.191E-3 6.229E-3 4 155
48 6133 DN Verteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.578E-6 1.462E-4 1.314E-3 7.070E-3 4 160
49 3556 DN Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.618E-6 1.462E-4 1.314E-3 7.248E-3 4 161
50 CID000147253 GSH-MEE Stitch 1.632E-6 1.462E-4 1.314E-3 7.311E-3 3 42
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 486 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0750901 Alzheimer Disease, Early Onset DisGeNET BeFree 1.310E-10 6.369E-8 4.308E-7 6.369E-8 5 43
2 C0333463 Senile Plaques DisGeNET BeFree 1.394E-9 2.612E-7 1.767E-6 6.774E-7 7 311
3 C0233407 Disorientation DisGeNET BeFree 1.613E-9 2.612E-7 1.767E-6 7.837E-7 3 4
4 C0494463 Alzheimer Disease, Late Onset DisGeNET BeFree 6.625E-9 8.049E-7 5.445E-6 3.220E-6 6 208
5 C2936349 Plaque, Amyloid DisGeNET Curated 1.375E-8 1.337E-6 9.044E-6 6.685E-6 6 235
6 C0085220 Cerebral Amyloid Angiopathy DisGeNET Curated 2.480E-8 2.009E-6 1.359E-5 1.205E-5 4 41
7 C0751071 Familial Dementia DisGeNET BeFree 4.824E-8 3.349E-6 2.266E-5 2.345E-5 3 10
8 C1863051 ALZHEIMER DISEASE 2 DisGeNET Curated 1.461E-7 8.873E-6 6.002E-5 7.099E-5 3 14
9 C2931784 Amyloid angiopathy DisGeNET BeFree 3.268E-7 1.765E-5 1.194E-4 1.588E-4 3 18
10 C0009676 Confusion DisGeNET Curated 1.038E-6 5.042E-5 3.411E-4 5.042E-4 3 26
11 C0338582 Sporadic Cerebral Amyloid Angiopathy DisGeNET BeFree 1.781E-6 7.215E-5 4.881E-4 8.658E-4 2 3
12 C1840560 Hidradenitis suppurativa, familial DisGeNET Curated 1.781E-6 7.215E-5 4.881E-4 8.658E-4 2 3
13 C0276496 Familial Alzheimer Disease (FAD) DisGeNET BeFree 1.942E-6 7.260E-5 4.911E-4 9.438E-4 4 120
14 C1270972 Mild cognitive disorder DisGeNET BeFree 4.981E-6 1.729E-4 1.170E-3 2.421E-3 4 152
15 C0262376 anxiety generalized DisGeNET BeFree 5.933E-6 1.922E-4 1.300E-3 2.883E-3 2 5
16 C0002622 Amnesia DisGeNET Curated 8.214E-6 2.495E-4 1.688E-3 3.992E-3 3 51
17 C1842937 AURAL ATRESIA, CONGENITAL DisGeNET BeFree 1.344E-5 3.815E-4 2.581E-3 6.533E-3 3 60
18 C0011389 Dental Plaque DisGeNET BeFree 1.413E-5 3.815E-4 2.581E-3 6.868E-3 3 61
19 C3811918 GRN-related frontotemporal dementia DisGeNET BeFree 1.558E-5 3.839E-4 2.597E-3 7.571E-3 3 63
20 C0029459 Osteoporosis, Senile DisGeNET BeFree 1.659E-5 3.839E-4 2.597E-3 8.062E-3 2 8
21 C0338460 Argyrophilic grain disease DisGeNET BeFree 1.659E-5 3.839E-4 2.597E-3 8.062E-3 2 8
22 C0085400 Neurofibrillary degeneration (morphologic abnormality) DisGeNET Curated 2.132E-5 4.317E-4 2.920E-3 1.036E-2 2 9
23 C0268394 Hereditary Cerebral Amyloid Angiopathy, Dutch Type DisGeNET Curated 2.132E-5 4.317E-4 2.920E-3 1.036E-2 2 9
24 C1411876 Developmental arithmetic disorder DisGeNET Curated 2.132E-5 4.317E-4 2.920E-3 1.036E-2 2 9
25 C0009241 Cognition Disorders DisGeNET Curated 2.781E-5 5.329E-4 3.605E-3 1.352E-2 4 235
26 C0751295 Memory Loss DisGeNET Curated 2.851E-5 5.329E-4 3.605E-3 1.386E-2 3 77
27 C0236642 Pick Disease of the Brain DisGeNET Curated 5.020E-5 9.036E-4 6.112E-3 2.440E-2 3 93
28 C0751072 Frontotemporal Lobar Degeneration DisGeNET Curated 5.693E-5 9.882E-4 6.684E-3 2.767E-2 3 97
29 C0334299 Carcinoid tumor no ICD-O subtype DisGeNET BeFree 6.614E-5 1.108E-3 7.498E-3 3.215E-2 3 102
30 C3887551 Memory dysfunction DisGeNET BeFree 7.084E-5 1.111E-3 7.513E-3 3.443E-2 2 16
31 C0004045 Asphyxia Neonatorum DisGeNET Curated 7.084E-5 1.111E-3 7.513E-3 3.443E-2 2 16
32 C0027066 Myoclonus DisGeNET Curated 7.418E-5 1.127E-3 7.621E-3 3.605E-2 3 106
33 C0282513 Primary Progressive Aphasia (disorder) DisGeNET BeFree 8.025E-5 1.182E-3 7.995E-3 3.900E-2 2 17
34 C0011265 Presenile dementia DisGeNET BeFree 8.612E-5 1.231E-3 8.327E-3 4.185E-2 4 314
35 C0162836 Hidradenitis Suppurativa DisGeNET Curated 9.024E-5 1.253E-3 8.476E-3 4.386E-2 2 18
36 C0027746 Nerve Degeneration DisGeNET Curated 1.073E-4 1.448E-3 9.798E-3
5.214E-2
 3 120
37 C0752347 Lewy Body Disease DisGeNET Curated 1.330E-4 1.747E-3 1.181E-2
6.462E-2
 3 129
38 C0265101 Carotid artery occlusion DisGeNET BeFree 1.489E-4 1.904E-3 1.288E-2
7.236E-2
 2 23
39 C0001787 Osteoporosis, Age-Related DisGeNET BeFree 1.623E-4 2.023E-3 1.368E-2
7.890E-2
 2 24
40 C0338451 Frontotemporal dementia DisGeNET Curated 1.730E-4 2.102E-3 1.422E-2
8.408E-2
 3 141
41 C0497327 Dementia DisGeNET Curated 2.028E-4 2.386E-3 1.614E-2
9.854E-2
 4 392
42 cv:C0007193 Primary dilated cardiomyopathy Clinical Variations 2.062E-4 2.386E-3 1.614E-2
1.002E-1
 2 27
43 C2931859 Acquired CJD DisGeNET BeFree 2.219E-4 2.451E-3 1.658E-2
1.079E-1
 2 28
44 C1852467 Creutzfeldt-Jakob Disease, Sporadic DisGeNET BeFree 2.219E-4 2.451E-3 1.658E-2
1.079E-1
 2 28
45 C0013080 Down Syndrome DisGeNET Curated 2.763E-4 2.984E-3 2.019E-2
1.343E-1
 4 425
46 C0525041 Neurobehavioral Manifestations DisGeNET Curated 2.907E-4 3.071E-3 2.078E-2
1.413E-1
 2 32
47 C0023186 Learning Disorders DisGeNET Curated 3.285E-4 3.397E-3 2.298E-2
1.596E-1
 2 34
48 C0039070 Syncope DisGeNET Curated 3.686E-4 3.732E-3 2.524E-2
1.791E-1
 2 36
49 C1860787 DOWN SYNDROME CRITICAL REGION DisGeNET BeFree 4.329E-4 4.257E-3 2.880E-2
2.104E-1
 2 39
50 C0007095 Carcinoid Tumor DisGeNET Curated 4.423E-4 4.257E-3 2.880E-2
2.149E-1
 3 194
Show 45 more annotations