Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc131_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 39 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005109 frizzled binding 5.092E-10 1.986E-8 8.448E-8 1.986E-8 4 38
2 GO:0017048 Rho GTPase binding 1.526E-8 1.990E-7 8.466E-7 5.951E-7 4 87
3 GO:0017016 Ras GTPase binding 1.531E-8 1.990E-7 8.466E-7 5.971E-7 5 281
4 GO:0031267 small GTPase binding 2.160E-8 2.106E-7 8.960E-7 8.426E-7 5 301
5 GO:0051020 GTPase binding 3.270E-8 2.551E-7 1.085E-6 1.275E-6 5 327
6 GO:0048365 Rac GTPase binding 3.687E-7 2.397E-6 1.019E-5 1.438E-5 3 42
7 GO:0001664 G protein-coupled receptor binding 1.583E-6 8.817E-6 3.750E-5 6.172E-5 4 276
8 GO:0008013 beta-catenin binding 3.620E-6 1.765E-5 7.506E-5 1.412E-4 3 89
9 GO:0043621 protein self-association 1.840E-4 7.972E-4 3.391E-3 7.175E-3 2 56
10 GO:0030674 protein binding, bridging 1.547E-3 6.034E-3 2.567E-2
6.034E-2
 2 163
11 GO:0060090 molecular adaptor activity 1.903E-3 6.747E-3 2.870E-2
7.421E-2
 2 181
12 GO:0070411 I-SMAD binding 4.120E-3 1.339E-2
5.695E-2
1.607E-1
 1 11
13 GO:0070016 armadillo repeat domain binding 4.867E-3 1.460E-2
6.211E-2
1.898E-1
 1 13
14 GO:0042813 Wnt-activated receptor activity 8.225E-3 2.291E-2
9.746E-2
3.208E-1
 1 22
15 GO:0070412 R-SMAD binding 8.970E-3 2.314E-2
9.842E-2
3.498E-1
 1 24
16 GO:0030159 receptor signaling complex scaffold activity 9.714E-3 2.314E-2
9.842E-2
3.788E-1
 1 26
17 GO:0030552 cAMP binding 1.009E-2 2.314E-2
9.842E-2
3.933E-1
 1 27
18 GO:0017147 Wnt-protein binding 1.194E-2 2.588E-2
1.101E-1
4.658E-1
 1 32
19 GO:0030551 cyclic nucleotide binding 1.528E-2 3.137E-2
1.334E-1
5.960E-1
 1 41
Show 14 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 626 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0090179 planar cell polarity pathway involved in neural tube closure 9.522E-12 3.464E-9 2.431E-8 5.961E-9 4 15
2 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure 1.269E-11 3.464E-9 2.431E-8 7.947E-9 4 16
3 GO:0090177 establishment of planar polarity involved in neural tube closure 1.660E-11 3.464E-9 2.431E-8 1.039E-8 4 17
4 GO:0042249 establishment of planar polarity of embryonic epithelium 2.702E-11 4.229E-9 2.968E-8 1.692E-8 4 19
5 GO:1904886 beta-catenin destruction complex disassembly 5.098E-11 6.383E-9 4.479E-8 3.192E-8 4 22
6 GO:0060071 Wnt signaling pathway, planar cell polarity pathway 1.565E-10 1.463E-8 1.027E-7 9.795E-8 5 113
7 GO:0090175 regulation of establishment of planar polarity 1.636E-10 1.463E-8 1.027E-7 1.024E-7 5 114
8 GO:0001736 establishment of planar polarity 2.719E-10 1.969E-8 1.382E-7 1.702E-7 5 126
9 GO:0007164 establishment of tissue polarity 2.830E-10 1.969E-8 1.382E-7 1.772E-7 5 127
10 GO:0001738 morphogenesis of a polarized epithelium 4.807E-10 3.009E-8 2.112E-7 3.009E-7 5 141
11 GO:0035567 non-canonical Wnt signaling pathway 8.823E-10 5.021E-8 3.523E-7 5.523E-7 5 159
12 GO:0090090 negative regulation of canonical Wnt signaling pathway 1.064E-9 5.549E-8 3.894E-7 6.659E-7 5 165
13 GO:0060027 convergent extension involved in gastrulation 1.820E-9 8.762E-8 6.149E-7 1.139E-6 3 8
14 GO:0016055 Wnt signaling pathway 2.314E-9 1.035E-7 7.262E-7 1.449E-6 6 494
15 GO:0030178 negative regulation of Wnt signaling pathway 3.023E-9 1.261E-7 8.852E-7 1.892E-6 5 203
16 GO:0060828 regulation of canonical Wnt signaling pathway 7.619E-9 2.981E-7 2.092E-6 4.770E-6 5 244
17 GO:2000027 regulation of animal organ morphogenesis 1.220E-8 4.492E-7 3.152E-6 7.636E-6 5 268
18 GO:0060026 convergent extension 1.817E-8 6.320E-7 4.435E-6 1.138E-5 3 16
19 GO:0060070 canonical Wnt signaling pathway 2.449E-8 8.068E-7 5.661E-6 1.533E-5 5 308
20 GO:0043506 regulation of JUN kinase activity 2.706E-8 8.468E-7 5.943E-6 1.694E-5 4 100
21 GO:0001843 neural tube closure 3.049E-8 8.631E-7 6.056E-6 1.909E-5 4 103
22 GO:0030111 regulation of Wnt signaling pathway 3.059E-8 8.631E-7 6.056E-6 1.915E-5 5 322
23 GO:0060606 tube closure 3.171E-8 8.631E-7 6.056E-6 1.985E-5 4 104
24 GO:0014020 primary neural tube formation 3.694E-8 9.635E-7 6.761E-6 2.312E-5 4 108
25 GO:0090103 cochlea morphogenesis 5.741E-8 1.407E-6 9.877E-6 3.594E-5 3 23
26 GO:0001841 neural tube formation 5.846E-8 1.407E-6 9.877E-6 3.659E-5 4 121
27 GO:0045995 regulation of embryonic development 6.245E-8 1.443E-6 1.012E-5 3.910E-5 4 123
28 GO:0090263 positive regulation of canonical Wnt signaling pathway 6.453E-8 1.443E-6 1.012E-5 4.039E-5 4 124
29 GO:0001838 embryonic epithelial tube formation 1.146E-7 2.459E-6 1.726E-5 7.174E-5 4 143
30 GO:0072175 epithelial tube formation 1.179E-7 2.459E-6 1.726E-5 7.378E-5 4 144
31 GO:0030177 positive regulation of Wnt signaling pathway 1.711E-7 3.434E-6 2.410E-5 1.071E-4 4 158
32 GO:0035148 tube formation 1.755E-7 3.434E-6 2.410E-5 1.099E-4 4 159
33 GO:0016331 morphogenesis of embryonic epithelium 2.407E-7 4.566E-6 3.204E-5 1.507E-4 4 172
34 GO:0046328 regulation of JNK cascade 3.086E-7 5.642E-6 3.959E-5 1.932E-4 4 183
35 GO:0021915 neural tube development 3.154E-7 5.642E-6 3.959E-5 1.975E-4 4 184
36 GO:0014022 neural plate elongation 3.633E-7 6.146E-6 4.313E-5 2.274E-4 2 3
37 GO:0022007 convergent extension involved in neural plate elongation 3.633E-7 6.146E-6 4.313E-5 2.274E-4 2 3
38 GO:0007369 gastrulation 3.741E-7 6.163E-6 4.325E-5 2.342E-4 4 192
39 GO:0090102 cochlea development 5.236E-7 8.404E-6 5.897E-5 3.278E-4 3 47
40 GO:0007254 JNK cascade 5.995E-7 9.382E-6 6.584E-5 3.753E-4 4 216
41 GO:0032872 regulation of stress-activated MAPK cascade 6.689E-7 1.015E-5 7.123E-5 4.187E-4 4 222
42 GO:0070302 regulation of stress-activated protein kinase signaling cascade 6.810E-7 1.015E-5 7.123E-5 4.263E-4 4 223
43 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation 1.210E-6 1.762E-5 1.237E-4 7.577E-4 2 5
44 GO:0051403 stress-activated MAPK cascade 1.505E-6 2.141E-5 1.503E-4 9.422E-4 4 272
45 GO:0032984 protein-containing complex disassembly 1.642E-6 2.234E-5 1.568E-4 1.028E-3 4 278
46 GO:0031098 stress-activated protein kinase signaling cascade 1.642E-6 2.234E-5 1.568E-4 1.028E-3 4 278
47 GO:0060029 convergent extension involved in organogenesis 1.815E-6 2.418E-5 1.697E-4 1.136E-3 2 6
48 GO:0090596 sensory organ morphogenesis 2.108E-6 2.749E-5 1.929E-4 1.320E-3 4 296
49 GO:0043507 positive regulation of JUN kinase activity 2.444E-6 3.123E-5 2.191E-4 1.530E-3 3 78
50 GO:0048562 embryonic organ morphogenesis 3.095E-6 3.875E-5 2.720E-4 1.938E-3 4 326
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 39 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990909 Wnt signalosome 1.102E-8 4.298E-7 1.828E-6 4.298E-7 3 14
2 GO:0060076 excitatory synapse 7.685E-5 1.499E-3 6.374E-3 2.997E-3 3 252
3 GO:0016328 lateral plasma membrane 1.579E-4 2.053E-3 8.731E-3 6.158E-3 2 53
4 GO:0098794 postsynapse 4.235E-4 4.129E-3 1.756E-2 1.652E-2 3 449
5 GO:0043197 dendritic spine 1.276E-3 7.158E-3 3.045E-2 4.975E-2 2 151
6 GO:0044309 neuron spine 1.309E-3 7.158E-3 3.045E-2
5.106E-2
 2 153
7 GO:0030136 clathrin-coated vesicle 1.466E-3 7.158E-3 3.045E-2
5.717E-2
 2 162
8 GO:0044316 cone cell pedicle 1.468E-3 7.158E-3 3.045E-2
5.726E-2
 1 4
9 GO:0030426 growth cone 1.845E-3 7.591E-3 3.229E-2
7.196E-2
 2 182
10 GO:0030427 site of polarized growth 1.946E-3 7.591E-3 3.229E-2
7.591E-2
 2 187
11 GO:0014069 postsynaptic density 2.975E-3 9.619E-3 4.091E-2
1.160E-1
 2 232
12 GO:0099572 postsynaptic specialization 2.975E-3 9.619E-3 4.091E-2
1.160E-1
 2 232
13 GO:0030135 coated vesicle 3.206E-3 9.619E-3 4.091E-2
1.250E-1
 2 241
14 GO:0005938 cell cortex 3.890E-3 1.084E-2 4.610E-2
1.517E-1
 2 266
15 GO:0030877 beta-catenin destruction complex 5.131E-3 1.334E-2
5.674E-2
2.001E-1
 1 14
16 GO:0099568 cytoplasmic region 5.751E-3 1.402E-2
5.963E-2
2.243E-1
 2 325
17 GO:0005874 microtubule 9.715E-3 2.124E-2
9.034E-2
3.789E-1
 2 426
18 GO:0045177 apical part of cell 9.803E-3 2.124E-2
9.034E-2
3.823E-1
 2 428
19 GO:0001917 photoreceptor inner segment 1.677E-2 3.443E-2
1.465E-1
6.542E-1
 1 46
20 GO:0005881 cytoplasmic microtubule 2.291E-2 4.190E-2
1.782E-1
8.936E-1
 1 63
21 GO:0097517 contractile actin filament bundle 2.435E-2 4.190E-2
1.782E-1
9.497E-1
 1 67
22 GO:0001725 stress fiber 2.435E-2 4.190E-2
1.782E-1
9.497E-1
 1 67
23 GO:0045334 clathrin-coated endocytic vesicle 2.471E-2 4.190E-2
1.782E-1
9.637E-1
 1 68
24 GO:0032432 actin filament bundle 2.651E-2 4.307E-2
1.832E-1
1.000E0
 1 73
25 GO:0042641 actomyosin 2.794E-2 4.359E-2
1.854E-1
1.000E0
 1 77
26 GO:0001750 photoreceptor outer segment 3.009E-2 4.514E-2
1.920E-1
1.000E0
 1 83
Show 21 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 541 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0040036 Onychogryposis of fingernail 8.125E-7 2.197E-4 1.510E-3 4.396E-4 2 3
2 HP:0001853 Bifid distal phalanx of toe 1.625E-6 2.197E-4 1.510E-3 8.790E-4 2 4
3 HP:0010733 Naevus flammeus of the eyelid 1.625E-6 2.197E-4 1.510E-3 8.790E-4 2 4
4 HP:0001705 Right ventricular outlet tract obstruction 1.625E-6 2.197E-4 1.510E-3 8.790E-4 2 4
5 HP:0012905 Euryblepharon 5.684E-6 5.125E-4 3.522E-3 3.075E-3 2 7
6 HP:0010290 Short hard palate 5.684E-6 5.125E-4 3.522E-3 3.075E-3 2 7
7 HP:0008402 Ridged fingernail 7.578E-6 5.857E-4 4.024E-3 4.100E-3 2 8
8 HP:0005107 Abnormal sacrum morphology 1.209E-5 8.173E-4 5.616E-3 6.538E-3 3 109
9 HP:0003422 Vertebral segmentation defect 1.459E-5 8.771E-4 6.027E-3 7.894E-3 3 116
10 HP:0100798 Fingernail dysplasia 2.461E-5 1.210E-3 8.316E-3 1.331E-2 2 14
11 HP:0009883 Duplication of the distal phalanx of hand 2.461E-5 1.210E-3 8.316E-3 1.331E-2 2 14
12 HP:0007665 Curly eyelashes 2.839E-5 1.280E-3 8.795E-3 1.536E-2 2 15
13 HP:0001028 Hemangioma 3.573E-5 1.339E-3 9.202E-3 1.933E-2 3 156
14 HP:0000064 Hypoplastic labia minora 3.676E-5 1.339E-3 9.202E-3 1.989E-2 2 17
15 HP:0100742 Vascular neoplasm 3.713E-5 1.339E-3 9.202E-3 2.009E-2 3 158
16 HP:0005743 Avascular necrosis of the capital femoral epiphysis 4.135E-5 1.389E-3 9.542E-3 2.237E-2 2 18
17 HP:0003027 Mesomelia 5.133E-5 1.389E-3 9.542E-3 2.777E-2 2 20
18 HP:0009370 Type A brachydactyly 5.133E-5 1.389E-3 9.542E-3 2.777E-2 2 20
19 HP:0001805 Thick nail 5.133E-5 1.389E-3 9.542E-3 2.777E-2 2 20
20 HP:0004220 Short middle phalanx of the 5th finger 5.133E-5 1.389E-3 9.542E-3 2.777E-2 2 20
21 HP:0009161 Aplasia/Hypoplasia of the middle phalanx of the 5th finger 6.239E-5 1.607E-3 1.104E-2 3.375E-2 2 22
22 HP:0100541 Femoral hernia 6.833E-5 1.607E-3 1.104E-2 3.696E-2 2 23
23 HP:0004219 Abnormality of the middle phalanx of the 5th finger 6.833E-5 1.607E-3 1.104E-2 3.696E-2 2 23
24 HP:0000207 Triangular mouth 7.453E-5 1.623E-3 1.115E-2 4.032E-2 2 24
25 HP:0000161 Median cleft lip 8.100E-5 1.623E-3 1.115E-2 4.382E-2 2 25
26 HP:0009099 Median cleft palate 8.100E-5 1.623E-3 1.115E-2 4.382E-2 2 25
27 HP:0008501 Median cleft lip and palate 8.100E-5 1.623E-3 1.115E-2 4.382E-2 2 25
28 HP:0010297 Bifid tongue 8.773E-5 1.637E-3 1.125E-2 4.746E-2 2 26
29 HP:0012880 Abnormality of the labia minora 8.773E-5 1.637E-3 1.125E-2 4.746E-2 2 26
30 HP:0000059 Hypoplastic labia majora 1.020E-4 1.780E-3 1.223E-2
5.519E-2
 2 28
31 HP:0000637 Long palpebral fissure 1.020E-4 1.780E-3 1.223E-2
5.519E-2
 2 28
32 HP:0100323 Juvenile aseptic necrosis 1.096E-4 1.852E-3 1.273E-2
5.927E-2
 2 29
33 HP:0009376 Aplasia/Hypoplasia of the phalanges of the 5th finger 1.174E-4 1.924E-3 1.322E-2
6.349E-2
 2 30
34 HP:0004213 Abnormal 5th finger phalanx morphology 1.338E-4 2.129E-3 1.463E-2
7.237E-2
 2 32
35 HP:0040255 Aplasia/Hypoplasia of the clitoris 1.424E-4 2.140E-3 1.470E-2
7.703E-2
 2 33
36 HP:0000060 Clitoral hypoplasia 1.424E-4 2.140E-3 1.470E-2
7.703E-2
 2 33
37 HP:0012881 Abnormality of the labia majora 1.513E-4 2.154E-3 1.480E-2
8.184E-2
 2 34
38 HP:0000674 Anodontia 1.513E-4 2.154E-3 1.480E-2
8.184E-2
 2 34
39 HP:0001052 Nevus flammeus 1.604E-4 2.225E-3 1.529E-2
8.678E-2
 2 35
40 HP:0000075 Renal duplication 1.698E-4 2.241E-3 1.540E-2
9.187E-2
 2 36
41 HP:0000039 Epispadias 1.698E-4 2.241E-3 1.540E-2
9.187E-2
 2 36
42 HP:0025104 Capillary malformation 1.795E-4 2.258E-3 1.552E-2
9.711E-2
 2 37
43 HP:0005306 Capillary hemangioma 1.795E-4 2.258E-3 1.552E-2
9.711E-2
 2 37
44 HP:0009237 Short 5th finger 1.894E-4 2.329E-3 1.601E-2
1.025E-1
 2 38
45 HP:0006262 Aplasia/Hypoplasia of the 5th finger 1.997E-4 2.400E-3 1.649E-2
1.080E-1
 2 39
46 HP:0000066 Labial hypoplasia 2.101E-4 2.419E-3 1.662E-2
1.137E-1
 2 40
47 HP:0000677 Oligodontia 2.101E-4 2.419E-3 1.662E-2
1.137E-1
 2 40
48 HP:0002937 Hemivertebrae 2.319E-4 2.614E-3 1.796E-2
1.255E-1
 2 42
49 HP:0010240 Hypoplasia of the middle phalanges of the hand 2.665E-4 2.884E-3 1.982E-2
1.442E-1
 2 45
50 HP:0005819 Short middle phalanx of finger 2.665E-4 2.884E-3 1.982E-2
1.442E-1
 2 45
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 7 input genes in category / 297 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008784 craniorachischisis 9.202E-10 2.733E-7 1.714E-6 2.733E-7 4 25
2 MP:0004407 increased cochlear hair cell number 6.861E-7 1.019E-4 6.391E-4 2.038E-4 3 29
3 MP:0003720 abnormal neural tube closure 1.533E-6 1.075E-4 6.741E-4 4.554E-4 5 394
4 MP:0005221 abnormal rostral-caudal axis patterning 1.550E-6 1.075E-4 6.741E-4 4.603E-4 4 153
5 MP:0004624 abnormal thoracic cage morphology 2.311E-6 1.075E-4 6.741E-4 6.864E-4 5 428
6 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles 2.476E-6 1.075E-4 6.741E-4 7.354E-4 3 44
7 MP:0000284 double outlet right ventricle 2.533E-6 1.075E-4 6.741E-4 7.523E-4 4 173
8 MP:0006006 increased sensory neuron number 6.368E-6 2.101E-4 1.318E-3 1.891E-3 3 60
9 MP:0004110 transposition of great arteries 6.368E-6 2.101E-4 1.318E-3 1.891E-3 3 60
10 MP:0004406 abnormal cochlear hair cell number 9.724E-6 2.757E-4 1.729E-3 2.888E-3 3 69
11 MP:0010426 abnormal heart and great artery attachment 1.079E-5 2.757E-4 1.729E-3 3.205E-3 4 249
12 MP:0010425 abnormal heart and great vessel attachment 1.114E-5 2.757E-4 1.729E-3 3.309E-3 4 251
13 MP:0002825 abnormal notochord morphology 1.463E-5 3.155E-4 1.979E-3 4.346E-3 3 79
14 MP:0000288 abnormal pericardium morphology 1.487E-5 3.155E-4 1.979E-3 4.418E-3 4 270
15 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology 2.240E-5 4.436E-4 2.782E-3 6.654E-3 3 91
16 MP:0000154 rib fusion 2.631E-5 4.838E-4 3.034E-3 7.814E-3 3 96
17 MP:0012675 enlarged floor plate 3.045E-5 4.838E-4 3.034E-3 9.043E-3 2 13
18 MP:0011099 lethality throughout fetal growth and development, complete penetrance 3.325E-5 4.838E-4 3.034E-3 9.876E-3 4 331
19 MP:0002633 persistent truncus arteriosis 3.542E-5 4.838E-4 3.034E-3 1.052E-2 3 106
20 MP:0008947 increased neuron number 3.643E-5 4.838E-4 3.034E-3 1.082E-2 3 107
21 MP:0010650 abnormal aorticopulmonary septum morphology 3.643E-5 4.838E-4 3.034E-3 1.082E-2 3 107
22 MP:0010651 aorticopulmonary septal defect 3.643E-5 4.838E-4 3.034E-3 1.082E-2 3 107
23 MP:0000592 short tail 3.746E-5 4.838E-4 3.034E-3 1.113E-2 3 108
24 MP:0011999 abnormal tail length 4.521E-5 5.595E-4 3.510E-3 1.343E-2 3 115
25 MP:0003047 abnormal thoracic vertebrae morphology 4.884E-5 5.802E-4 3.639E-3 1.450E-2 3 118
26 MP:0010454 abnormal truncus arteriosus septation 5.135E-5 5.866E-4 3.680E-3 1.525E-2 3 120
27 MP:0003456 absent tail 5.963E-5 6.453E-4 4.048E-3 1.771E-2 2 18
28 MP:0000585 kinked tail 6.084E-5 6.453E-4 4.048E-3 1.807E-2 3 127
29 MP:0000267 abnormal heart development 7.067E-5 7.237E-4 4.540E-3 2.099E-2 4 401
30 MP:0000757 herniated abdominal wall 7.400E-5 7.326E-4 4.595E-3 2.198E-2 2 20
31 MP:0005312 pericardial effusion 7.965E-5 7.631E-4 4.786E-3 2.366E-2 3 139
32 MP:0006113 abnormal heart septum morphology 1.007E-4 9.348E-4 5.864E-3 2.991E-2 4 439
33 MP:0004399 abnormal cochlear outer hair cell morphology 1.102E-4 9.776E-4 6.132E-3 3.272E-2 3 155
34 MP:0011092 embryonic lethality, complete penetrance 1.119E-4 9.776E-4 6.132E-3 3.324E-2 4 451
35 MP:0012173 short rostral-caudal axis 1.263E-4 1.072E-3 6.724E-3 3.752E-2 2 26
36 MP:0006126 abnormal cardiac outflow tract development 1.424E-4 1.175E-3 7.372E-3 4.231E-2 3 169
37 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles 1.805E-4 1.449E-3 9.086E-3
5.360E-2
 2 31
38 MP:0002622 abnormal cochlear hair cell morphology 2.244E-4 1.754E-3 1.100E-2
6.663E-2
 3 197
39 MP:0003308 abnormal cochlear sensory epithelium morphology 2.452E-4 1.824E-3 1.144E-2
7.282E-2
 3 203
40 MP:0000045 abnormal hair cell morphology 2.524E-4 1.824E-3 1.144E-2
7.496E-2
 3 205
41 MP:0000042 abnormal organ of Corti morphology 2.524E-4 1.824E-3 1.144E-2
7.496E-2
 3 205
42 MP:0000277 abnormal heart shape 2.580E-4 1.824E-3 1.144E-2
7.662E-2
 2 37
43 MP:0000459 abnormal presacral vertebrae morphology 3.365E-4 2.324E-3 1.458E-2
9.995E-2
 3 226
44 MP:0000972 abnormal mechanoreceptor morphology 3.499E-4 2.347E-3 1.472E-2
1.039E-1
 3 229
45 MP:0003169 abnormal scala media morphology 3.635E-4 2.347E-3 1.472E-2
1.080E-1
 3 232
46 MP:0004426 abnormal cochlear labyrinth morphology 3.635E-4 2.347E-3 1.472E-2
1.080E-1
 3 232
47 MP:0001688 abnormal somite development 4.166E-4 2.633E-3 1.651E-2
1.237E-1
 3 243
48 MP:0000031 abnormal cochlea morphology 4.268E-4 2.641E-3 1.657E-2
1.268E-1
 3 245
49 MP:0000925 abnormal floor plate morphology 4.916E-4 2.980E-3 1.869E-2
1.460E-1
 2 51
50 MP:0000929 open neural tube 5.140E-4 3.027E-3 1.899E-2
1.526E-1
 3 261
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 91 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00021 DAX SMART 2.386E-13 5.429E-12 2.765E-11 2.171E-11 4 7
2 PS50841 DIX PROSITE 2.386E-13 5.429E-12 2.765E-11 2.171E-11 4 7
3 IPR001158 DIX InterPro 2.386E-13 5.429E-12 2.765E-11 2.171E-11 4 7
4 PF00778 DIX Pfam 2.386E-13 5.429E-12 2.765E-11 2.171E-11 4 7
5 IPR024580 Dishevelled C-dom InterPro 3.194E-11 4.844E-10 2.467E-9 2.906E-9 3 3
6 PF12316 Dsh C Pfam 3.194E-11 4.844E-10 2.467E-9 2.906E-9 3 3
7 PS50186 DEP PROSITE 4.978E-11 5.033E-10 2.564E-9 4.530E-9 4 22
8 SM00049 DEP SMART 4.978E-11 5.033E-10 2.564E-9 4.530E-9 4 22
9 PF00610 DEP Pfam 4.978E-11 5.033E-10 2.564E-9 4.530E-9 4 22
10 IPR000591 DEP dom InterPro 6.025E-11 5.482E-10 2.793E-9 5.482E-9 4 23
11 IPR015506 Dsh/Dvl-rel InterPro 1.277E-10 8.303E-10 4.229E-9 1.162E-8 3 4
12 IPR003351 Dishevelled protein dom InterPro 1.277E-10 8.303E-10 4.229E-9 1.162E-8 3 4
13 IPR008339 Dishevelled fam InterPro 1.277E-10 8.303E-10 4.229E-9 1.162E-8 3 4
14 PF02377 Dishevelled Pfam 1.277E-10 8.303E-10 4.229E-9 1.162E-8 3 4
15 IPR029071 Ubiquitin-rel dom InterPro 1.789E-9 1.085E-8 5.527E-8 1.628E-7 5 184
16 1.10.10.10 - Gene3D 6.074E-7 3.454E-6 1.759E-5 5.527E-5 4 218
17 IPR011991 WHTH DNA-bd dom InterPro 9.373E-7 5.017E-6 2.556E-5 8.529E-5 4 243
18 PF00595 PDZ Pfam 1.429E-5 7.222E-5 3.679E-4 1.300E-3 3 141
19 SM00228 PDZ SMART 1.652E-5 7.401E-5 3.770E-4 1.503E-3 3 148
20 2.30.42.10 - Gene3D 1.720E-5 7.401E-5 3.770E-4 1.565E-3 3 150
21 PS50106 PDZ PROSITE 1.754E-5 7.401E-5 3.770E-4 1.596E-3 3 151
22 IPR001478 PDZ InterPro 1.789E-5 7.401E-5 3.770E-4 1.628E-3 3 152
23 IPR027650 DAAM1 InterPro 3.736E-4 1.214E-3 6.185E-3 3.400E-2 1 1
24 IPR008341 DVL2 InterPro 3.736E-4 1.214E-3 6.185E-3 3.400E-2 1 1
25 IPR026559 SFRP1 InterPro 3.736E-4 1.214E-3 6.185E-3 3.400E-2 1 1
26 IPR031189 RAPGEF4 InterPro 3.736E-4 1.214E-3 6.185E-3 3.400E-2 1 1
27 IPR029797 AXIN1 InterPro 3.736E-4 1.214E-3 6.185E-3 3.400E-2 1 1
28 IPR008342 DVL3 InterPro 3.736E-4 1.214E-3 6.185E-3 3.400E-2 1 1
29 IPR014936 Axin b-cat-bd InterPro 7.471E-4 2.060E-3 1.049E-2
6.799E-2
 1 2
30 IPR008340 DVL-1 InterPro 7.471E-4 2.060E-3 1.049E-2
6.799E-2
 1 2
31 PF16646 AXIN1 TNKS BD Pfam 7.471E-4 2.060E-3 1.049E-2
6.799E-2
 1 2
32 IPR032101 Axin TNKS-bd InterPro 7.471E-4 2.060E-3 1.049E-2
6.799E-2
 1 2
33 PF08833 Axin b-cat bind Pfam 7.471E-4 2.060E-3 1.049E-2
6.799E-2
 1 2
34 PS51231 DAD PROSITE 2.986E-3 7.454E-3 3.797E-2
2.717E-1
 1 8
35 IPR014767 DAD dom InterPro 2.986E-3 7.454E-3 3.797E-2
2.717E-1
 1 8
36 SM01140 Drf GBD SMART 3.358E-3 7.454E-3 3.797E-2
3.056E-1
 1 9
37 SM01139 Drf FH3 SMART 3.358E-3 7.454E-3 3.797E-2
3.056E-1
 1 9
38 IPR010472 FH3 dom InterPro 3.358E-3 7.454E-3 3.797E-2
3.056E-1
 1 9
39 IPR010473 GTPase-bd InterPro 3.358E-3 7.454E-3 3.797E-2
3.056E-1
 1 9
40 PF06367 Drf FH3 Pfam 3.358E-3 7.454E-3 3.797E-2
3.056E-1
 1 9
41 PF06371 Drf GBD Pfam 3.358E-3 7.454E-3 3.797E-2
3.056E-1
 1 9
42 IPR014768 GBD/FH3 dom InterPro 4.103E-3 8.684E-3 4.423E-2
3.734E-1
 1 11
43 PS51232 GBD FH3 PROSITE 4.103E-3 8.684E-3 4.423E-2
3.734E-1
 1 11
44 IPR019804 Ras G-nucl-exch fac CS InterPro 5.220E-3 1.060E-2
5.400E-2
4.750E-1
 1 14
45 IPR015425 FH2 Formin InterPro 5.592E-3 1.060E-2
5.400E-2
5.089E-1
 1 15
46 PF02181 FH2 Pfam 5.592E-3 1.060E-2
5.400E-2
5.089E-1
 1 15
47 SM00498 FH2 SMART 5.592E-3 1.060E-2
5.400E-2
5.089E-1
 1 15
48 PS51444 FH2 PROSITE 5.592E-3 1.060E-2
5.400E-2
5.089E-1
 1 15
49 IPR015526 Frizzled/SFRP InterPro 5.964E-3 1.108E-2
5.641E-2
5.427E-1
 1 16
50 SM00643 C345C SMART 6.335E-3 1.153E-2
5.873E-2
5.765E-1
 1 17
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 86 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83061 Wnt signaling pathway BioSystems: KEGG 1.433E-11 1.233E-9 6.209E-9 1.233E-9 6 143
2 M5493 Genes related to Wnt-mediated signal transduction MSigDB C2 BIOCARTA (v6.0) 3.460E-10 1.488E-8 7.496E-8 2.976E-8 5 89
3 169354 Noncanonical Wnt signaling pathway BioSystems: Pathway Interaction Database 9.538E-10 2.152E-8 1.084E-7 8.203E-8 4 30
4 138032 Canonical Wnt signaling pathway BioSystems: Pathway Interaction Database 1.095E-9 2.152E-8 1.084E-7 9.416E-8 4 31
5 1269601 Disassembly of the destruction complex and recruitment of AXIN to the membrane BioSystems: REACTOME 1.251E-9 2.152E-8 1.084E-7 1.076E-7 4 32
6 1269609 Negative regulation of TCF-dependent signaling by DVL-interacting proteins BioSystems: REACTOME 2.175E-9 3.118E-8 1.571E-7 1.871E-7 3 6
7 1269594 Signaling by Wnt BioSystems: REACTOME 2.717E-9 3.338E-8 1.682E-7 2.337E-7 6 340
8 P00005 Angiogenesis PantherDB 4.892E-9 5.259E-8 2.649E-7 4.207E-7 5 150
9 83113 Basal cell carcinoma BioSystems: KEGG 1.181E-8 1.121E-7 5.649E-7 1.016E-6 4 55
10 1269600 WNT mediated activation of DVL BioSystems: REACTOME 1.304E-8 1.121E-7 5.649E-7 1.121E-6 3 10
11 PW:0000200 the planar cell polarity Wnt signaling Pathway Ontology 4.938E-8 3.861E-7 1.945E-6 4.247E-6 3 15
12 1269599 TCF dependent signaling in response to WNT BioSystems: REACTOME 5.418E-8 3.883E-7 1.956E-6 4.660E-6 5 242
13 1269611 PCP/CE pathway BioSystems: REACTOME 1.241E-7 8.208E-7 4.135E-6 1.067E-5 4 98
14 P00057 Wnt signaling pathway PantherDB 1.723E-7 1.058E-6 5.332E-6 1.482E-5 5 305
15 1269519 RHO GTPases Activate Formins BioSystems: REACTOME 2.537E-7 1.455E-6 7.328E-6 2.182E-5 4 117
16 1026136 Signaling pathways regulating pluripotency of stem cells BioSystems: KEGG 5.075E-7 2.728E-6 1.374E-5 4.364E-5 4 139
17 1435207 Breast cancer BioSystems: KEGG 5.848E-7 2.817E-6 1.419E-5 5.030E-5 4 144
18 PW:0000008 Wnt signaling Pathway Ontology 5.896E-7 2.817E-6 1.419E-5 5.070E-5 3 33
19 M17761 Wnt/beta-catenin Pathway MSigDB C2 BIOCARTA (v6.0) 6.465E-7 2.926E-6 1.474E-5 5.560E-5 3 34
20 1269610 Beta-catenin independent WNT signaling BioSystems: REACTOME 7.075E-7 3.042E-6 1.533E-5 6.085E-5 4 151
21 749777 Hippo signaling pathway BioSystems: KEGG 7.656E-7 3.135E-6 1.579E-5 6.584E-5 4 154
22 83062 Notch signaling pathway BioSystems: KEGG 1.862E-6 7.280E-6 3.667E-5 1.602E-4 3 48
23 1269605 Degradation of DVL BioSystems: REACTOME 3.863E-6 1.444E-5 7.276E-5 3.322E-4 3 61
24 1269509 RHO GTPase Effectors BioSystems: REACTOME 1.022E-5 3.662E-5 1.845E-4 8.789E-4 4 295
25 83092 Melanogenesis BioSystems: KEGG 1.771E-5 6.094E-5 3.070E-4 1.523E-3 3 101
26 M16173 Presenilin action in Notch and Wnt signaling MSigDB C2 BIOCARTA (v6.0) 2.458E-5 7.904E-5 3.982E-4 2.114E-3 2 14
27 P00004 Alzheimer disease-presenilin pathway PantherDB 2.482E-5 7.904E-5 3.982E-4 2.134E-3 3 113
28 M8516 Multi-step Regulation of Transcription by Pitx2 MSigDB C2 BIOCARTA (v6.0) 2.835E-5 8.709E-5 4.387E-4 2.438E-3 2 15
29 83105 Pathways in cancer BioSystems: KEGG 3.238E-5 9.602E-5 4.837E-4 2.784E-3 4 395
30 1269507 Signaling by Rho GTPases BioSystems: REACTOME 4.521E-5 1.296E-4 6.529E-4 3.888E-3 4 430
31 83059 mTOR signaling pathway BioSystems: KEGG 5.907E-5 1.639E-4 8.255E-4 5.080E-3 3 151
32 M16517 WNT Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 8.751E-5 2.352E-4 1.185E-3 7.525E-3 2 26
33 M11106 Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages MSigDB C2 BIOCARTA (v6.0) 9.448E-5 2.462E-4 1.240E-3 8.125E-3 2 27
34 M17400 ALK in cardiac myocytes MSigDB C2 BIOCARTA (v6.0) 1.788E-4 4.522E-4 2.278E-3 1.538E-2 2 37
35 PW:0000201 canonical Wnt signaling Pathway Ontology 2.772E-4 6.575E-4 3.312E-3 2.384E-2 2 46
36 137914 Presenilin action in Notch and Wnt signaling BioSystems: Pathway Interaction Database 2.772E-4 6.575E-4 3.312E-3 2.384E-2 2 46
37 373901 HTLV-I infection BioSystems: KEGG 2.829E-4 6.575E-4 3.312E-3 2.433E-2 3 256
38 PW:0000599 altered canonical Wnt signaling Pathway Ontology 2.809E-3 6.356E-3 3.202E-2
2.415E-1
 1 5
39 1268915 Truncations of AMER1 destabilize the destruction complex BioSystems: REACTOME 7.847E-3 1.390E-2
7.003E-2
6.748E-1
 1 14
40 1268913 AMER1 mutants destabilize the destruction complex BioSystems: REACTOME 7.847E-3 1.390E-2
7.003E-2
6.748E-1
 1 14
41 1268907 truncated APC mutants destabilize the destruction complex BioSystems: REACTOME 7.847E-3 1.390E-2
7.003E-2
6.748E-1
 1 14
42 1268912 AXIN missense mutants destabilize the destruction complex BioSystems: REACTOME 7.847E-3 1.390E-2
7.003E-2
6.748E-1
 1 14
43 1268910 AXIN mutants destabilize the destruction complex, activating WNT signaling BioSystems: REACTOME 7.847E-3 1.390E-2
7.003E-2
6.748E-1
 1 14
44 1268909 APC truncation mutants have impaired AXIN binding BioSystems: REACTOME 7.847E-3 1.390E-2
7.003E-2
6.748E-1
 1 14
45 1269613 WNT5A-dependent internalization of FZD4 BioSystems: REACTOME 8.405E-3 1.390E-2
7.003E-2
7.229E-1
 1 15
46 1268917 S45 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 8.405E-3 1.390E-2
7.003E-2
7.229E-1
 1 15
47 1268919 S37 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 8.405E-3 1.390E-2
7.003E-2
7.229E-1
 1 15
48 1269608 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BioSystems: REACTOME 8.405E-3 1.390E-2
7.003E-2
7.229E-1
 1 15
49 1268920 S33 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 8.405E-3 1.390E-2
7.003E-2
7.229E-1
 1 15
50 1268916 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex BioSystems: REACTOME 8.405E-3 1.390E-2
7.003E-2
7.229E-1
 1 15
Show 45 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1093 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12805222 Regulation of the Wnt signaling pathway by disabled-2 (Dab2). Pubmed 4.973E-14 5.436E-11 4.117E-10 5.436E-11 4 9
2 10644691 Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. Pubmed 1.302E-13 7.117E-11 5.391E-10 1.423E-10 4 11
3 24431302 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. Pubmed 2.359E-13 8.594E-11 6.509E-10 2.578E-10 5 64
4 19515997 Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Pubmed 1.142E-12 3.120E-10 2.364E-9 1.248E-9 5 87
5 18093802 Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
6 27744318 Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
7 18162551 Mechanism of activation of the Formin protein Daam1. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
8 25043421 Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
9 27086035 Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
10 8973355 Genomic organization of mouse Dishevelled genes. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
11 18692936 Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
12 21092292 Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
13 23437169 Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals. Pubmed 3.770E-12 3.169E-10 2.401E-9 4.120E-9 3 3
14 24852369 Atmin mediates kidney morphogenesis by modulating Wnt signaling. Pubmed 4.190E-12 3.271E-10 2.478E-9 4.580E-9 4 24
15 24643799 Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
16 27599467 The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
17 9192851 Human dishevelled genes constitute a DHR-containing multigene family. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
18 23371553 Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
19 11113207 Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
20 19465938 Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
21 8817329 cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
22 25557784 DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
23 17593335 Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
24 19625296 Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
25 18772438 Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Pubmed 1.508E-11 6.592E-10 4.993E-9 1.648E-8 3 4
26 11779461 Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Pubmed 3.769E-11 1.373E-9 1.040E-8 4.120E-8 3 5
27 15456783 Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. Pubmed 3.769E-11 1.373E-9 1.040E-8 4.120E-8 3 5
28 25424568 A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Pubmed 3.769E-11 1.373E-9 1.040E-8 4.120E-8 3 5
29 24469800 CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Pubmed 3.769E-11 1.373E-9 1.040E-8 4.120E-8 3 5
30 22826439 The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein. Pubmed 3.769E-11 1.373E-9 1.040E-8 4.120E-8 3 5
31 18351675 Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos. Pubmed 7.023E-11 2.423E-9 1.835E-8 7.677E-8 4 47
32 19008950 Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. Pubmed 7.538E-11 2.423E-9 1.835E-8 8.239E-8 3 6
33 20439735 SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Pubmed 7.538E-11 2.423E-9 1.835E-8 8.239E-8 3 6
34 21880741 Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. Pubmed 7.538E-11 2.423E-9 1.835E-8 8.239E-8 3 6
35 17005174 Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling. Pubmed 1.319E-10 3.604E-9 2.730E-8 1.442E-7 3 7
36 10330403 Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. Pubmed 1.319E-10 3.604E-9 2.730E-8 1.442E-7 3 7
37 10806215 Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. Pubmed 1.319E-10 3.604E-9 2.730E-8 1.442E-7 3 7
38 15262978 The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. Pubmed 1.319E-10 3.604E-9 2.730E-8 1.442E-7 3 7
39 12165471 Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Pubmed 1.319E-10 3.604E-9 2.730E-8 1.442E-7 3 7
40 22773187 Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. Pubmed 1.319E-10 3.604E-9 2.730E-8 1.442E-7 3 7
41 19388021 Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Pubmed 2.110E-10 5.625E-9 4.261E-8 2.306E-7 3 8
42 22899650 LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Pubmed 3.165E-10 8.045E-9 6.094E-8 3.459E-7 3 9
43 16487141 Expression of planar cell polarity genes during development of the mouse CNS. Pubmed 3.165E-10 8.045E-9 6.094E-8 3.459E-7 3 9
44 15637299 Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Pubmed 4.521E-10 1.123E-8 8.507E-8 4.942E-7 3 10
45 12433684 Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region. Pubmed 8.287E-10 1.927E-8 1.460E-7 9.058E-7 3 12
46 23122850 Microtubules enable the planar cell polarity of airway cilia. Pubmed 8.287E-10 1.927E-8 1.460E-7 9.058E-7 3 12
47 12421720 Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Pubmed 8.287E-10 1.927E-8 1.460E-7 9.058E-7 3 12
48 20412773 The Hippo pathway regulates Wnt/beta-catenin signaling. Pubmed 1.077E-9 2.453E-8 1.858E-7 1.177E-6 3 13
49 22771245 The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Pubmed 1.714E-9 3.822E-8 2.895E-7 1.873E-6 3 15
50 20970343 Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein. Pubmed 2.561E-9 5.597E-8 4.240E-7 2.799E-6 3 17
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 419 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DVL1 DVL1 interactions 2.321E-11 9.724E-9 6.434E-8 9.724E-9 5 74
2 int:DVL2 DVL2 interactions 2.308E-9 4.835E-7 3.199E-6 9.671E-7 5 183
3 int:LRRK2 LRRK2 interactions 1.323E-8 1.847E-6 1.222E-5 5.542E-6 5 259
4 int:DAB2 DAB2 interactions 2.065E-8 2.163E-6 1.431E-5 8.652E-6 4 89
5 int:DVL3 DVL3 interactions 3.881E-8 3.252E-6 2.152E-5 1.626E-5 4 104
6 int:AGRN AGRN interactions 8.675E-8 6.058E-6 4.008E-5 3.635E-5 3 25
7 int:AXIN1 AXIN1 interactions 1.016E-7 6.081E-6 4.023E-5 4.257E-5 4 132
8 int:DAAM1 DAAM1 interactions 1.377E-7 7.213E-6 4.772E-5 5.771E-5 3 29
9 int:RASSF9 RASSF9 interactions 3.175E-7 1.298E-5 8.587E-5 1.330E-4 3 38
10 int:CSNK1E CSNK1E interactions 3.303E-7 1.298E-5 8.587E-5 1.384E-4 4 177
11 int:RASSF10 RASSF10 interactions 3.439E-7 1.298E-5 8.587E-5 1.441E-4 3 39
12 int:VANGL2 VANGL2 interactions 3.717E-7 1.298E-5 8.587E-5 1.557E-4 3 40
13 int:WWTR1 WWTR1 interactions 5.334E-7 1.719E-5 1.137E-4 2.235E-4 3 45
14 int:VANGL1 VANGL1 interactions 6.498E-7 1.945E-5 1.287E-4 2.723E-4 3 48
15 int:PRICKLE1 PRICKLE1 interactions 4.818E-6 1.346E-4 8.905E-4 2.019E-3 2 9
16 int:CSNK1D CSNK1D interactions 5.842E-6 1.530E-4 1.012E-3 2.448E-3 3 99
17 int:CEP19 CEP19 interactions 6.975E-6 1.719E-4 1.137E-3 2.922E-3 3 105
18 int:PPM1A PPM1A interactions 7.592E-6 1.767E-4 1.169E-3 3.181E-3 3 108
19 int:NUMA1 NUMA1 interactions 9.659E-6 2.130E-4 1.409E-3 4.047E-3 3 117
20 int:CEP44 CEP44 interactions 1.655E-5 3.374E-4 2.232E-3 6.936E-3 3 140
21 int:SMURF2 SMURF2 interactions 1.691E-5 3.374E-4 2.232E-3 7.086E-3 3 141
22 int:DPPA2 DPPA2 interactions 2.538E-5 4.833E-4 3.198E-3 1.063E-2 2 20
23 int:CEP135 CEP135 interactions 2.857E-5 5.205E-4 3.444E-3 1.197E-2 3 168
24 int:ITCH ITCH interactions 4.324E-5 7.549E-4 4.994E-3 1.812E-2 3 193
25 int:BAHD1 BAHD1 interactions 5.414E-5 9.073E-4 6.003E-3 2.268E-2 2 29
26 int:SSX2IP SSX2IP interactions 8.070E-5 1.301E-3 8.604E-3 3.381E-2 3 238
27 int:WWOX WWOX interactions 1.061E-4 1.576E-3 1.043E-2 4.447E-2 3 261
28 int:ARRB1 ARRB1 interactions 1.086E-4 1.576E-3 1.043E-2 4.549E-2 3 263
29 int:HOMEZ HOMEZ interactions 1.091E-4 1.576E-3 1.043E-2 4.571E-2 2 41
30 int:ENKD1 ENKD1 interactions 1.145E-4 1.600E-3 1.058E-2 4.799E-2 2 42
31 int:CEP128 CEP128 interactions 1.253E-4 1.693E-3 1.120E-2
5.248E-2
 3 276
32 int:PSMF1 PSMF1 interactions 2.043E-4 2.675E-3 1.770E-2
8.560E-2
 2 56
33 int:WT1 WT1 interactions 2.506E-4 3.182E-3 2.105E-2
1.050E-1
 2 62
34 int:NXF2 NXF2 interactions 2.588E-4 3.189E-3 2.110E-2
1.084E-1
 2 63
35 int:RUNX2 RUNX2 interactions 2.755E-4 3.298E-3 2.182E-2
1.154E-1
 2 65
36 int:TRAF2 TRAF2 interactions 2.861E-4 3.330E-3 2.203E-2
1.199E-1
 3 365
37 int:KLHL12 KLHL12 interactions 3.475E-4 3.936E-3 2.604E-2
1.456E-1
 2 73
38 int:HIPK2 HIPK2 interactions 3.668E-4 4.045E-3 2.676E-2
1.537E-1
 2 75
39 int:CARD9 CARD9 interactions 4.070E-4 4.372E-3 2.893E-2
1.705E-1
 2 79
40 int:ZBTB48 ZBTB48 interactions 5.636E-4 5.904E-3 3.906E-2
2.361E-1
 2 93
41 int:NOL12 NOL12 interactions 6.004E-4 5.990E-3 3.963E-2
2.516E-1
 2 96
42 int:INVS INVS interactions 6.004E-4 5.990E-3 3.963E-2
2.516E-1
 2 96
43 int:FOXK1 FOXK1 interactions 6.513E-4 6.346E-3 4.199E-2
2.729E-1
 2 100
44 int:ATN1 ATN1 interactions 7.177E-4 6.834E-3 4.522E-2
3.007E-1
 2 105
45 int:SMAD7 SMAD7 interactions 7.591E-4 7.042E-3 4.659E-2
3.180E-1
 2 108
46 int:KIAA0753 KIAA0753 interactions 7.731E-4 7.042E-3 4.659E-2
3.239E-1
 2 109
47 int:DYNLT1 DYNLT1 interactions 1.047E-3 9.337E-3
6.178E-2
4.388E-1
 2 127
48 int:ODF2 ODF2 interactions 1.131E-3 9.856E-3
6.521E-2
4.738E-1
 2 132
49 int:WNT8A WNT8A interactions 1.186E-3 9.856E-3
6.521E-2
4.969E-1
 1 3
50 int:NKD1 NKD1 interactions 1.186E-3 9.856E-3
6.521E-2
4.969E-1
 1 3
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q31-q32 2q31-q32 8.076E-4 5.653E-3 1.466E-2 5.653E-3 1 4
2 8p11.21 8p11.21 4.636E-3 1.176E-2 3.048E-2 3.245E-2 1 23
3 3q27 3q27 5.038E-3 1.176E-2 3.048E-2 3.527E-2 1 25
4 14q23.1 14q23.1 9.454E-3 1.464E-2 3.795E-2
6.618E-2
 1 47
5 1p36 1p36 1.046E-2 1.464E-2 3.795E-2
7.319E-2
 1 52
6 17p13.1 17p13.1 2.438E-2 2.845E-2
7.376E-2
1.707E-1
 1 122
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 78 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 505 Dishevelled segment polarity proteins genenames.org 3.985E-11 1.594E-10 3.321E-10 1.594E-10 3 4
2 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 5.647E-6 1.129E-5 2.353E-5 2.259E-5 3 152
3 733 Secreted frizzled-related proteins genenames.org 1.373E-3 1.831E-3 3.815E-3 5.494E-3 1 5
4 694 Protein phosphatase 1 regulatory subunits genenames.org 4.877E-2 4.877E-2
1.016E-1
1.951E-1
 1 181

13: Coexpression [Display Chart] 7 input genes in category / 753 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5825 Angiogenic markers down-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.182E-8 3.149E-5 2.268E-4 3.149E-5 4 138
2 17935615-Table2 Mouse Bladder Buckley07 34genes GeneSigDB 2.346E-5 6.888E-3 4.960E-2 1.767E-2 2 25
3 M1391 Cluster 7 of genes distinguishing among different B lymphocyte neoplasms. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.744E-5 6.888E-3 4.960E-2 2.066E-2 2 27
4 16024939-Table2 Human Breast Scibetta05 53genes ad5 down GeneSigDB 6.398E-5 1.012E-2
7.285E-2
 4.817E-2 2 41
5 M5895 Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. MSigDB H: Hallmark Gene Sets (v6.0) 6.717E-5 1.012E-2
7.285E-2
5.058E-2
 2 42
6 16397240-Table1e Human Colon Grade06 58genes GeneSigDB 8.792E-5 1.103E-2
7.947E-2
6.620E-2
 2 48
7 17210682-Table2b Human Colon Grade07 101genes GeneSigDB 1.287E-4 1.384E-2
9.967E-2
9.688E-2
 2 58
8 20013794-Table3 Human CardiacCells Haag09 64genes GeneSigDB 1.471E-4 1.385E-2
9.971E-2
1.108E-1
 2 62
9 20124481-SuppTable1 Human Leukemia Marina10 94genes GeneSigDB 2.212E-4 1.851E-2
1.333E-1
1.666E-1
 2 76
10 M2892 Genes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 7.806E-4 3.686E-2
2.654E-1
5.878E-1
 2 143
11 M343 Genes up-regulated in tracheal epithelial cells infected with UV inactivated versus intact Sendai virus. MSigDB C7: Immunologic Signatures (v6.0) 8.024E-4 3.686E-2
2.654E-1
6.042E-1
 2 145
12 17150101-TableS1f Human Breast Troester06 3genes-up DOX-ME16C GeneSigDB 9.074E-4 3.686E-2
2.654E-1
6.833E-1
 1 3
13 M2654 Genes up-regulated in MCF-7 cells (breast cancer) over-expressing CCND1 [Gene ID=595] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.343E-3 3.686E-2
2.654E-1
1.000E0
 2 188
14 M8012 Genes up-regulated in macrophages (12h): IFNG and TNF [GeneID=3458;7124] versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 1.414E-3 3.686E-2
2.654E-1
1.000E0
 2 193
15 M5235 Genes up-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.686E-2
2.654E-1
1.000E0
 2 199
16 M5215 Genes up-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus DCs exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.686E-2
2.654E-1
1.000E0
 2 199
17 17881637-Table5 Human Lymphoma Young07 06genes GeneSigDB 1.512E-3 3.686E-2
2.654E-1
1.000E0
 1 5
18 M3599 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with IL12. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
19 M3025 Genes down-regulated in comparison of effector CD8 T cells at the peak expansion phase (day8) versus those at contraction (day 15) after LCMV-Armstrong infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
20 M3589 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with IL12 . MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
21 M3488 Genes down-regulated in naive CD4 [GeneID=920] T cells from adult blood versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
22 M9208 Genes up-regulated in CD8 T cells treated by interferon alpha: naïve versus day 8 after LCMV infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
23 M3612 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
24 M297 Genes down-regulated in allogeneic T cells after stimulation with dendritic cells from: peripheral lymph nodes (mLN) versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
25 M9967 Genes up-regulated in CD8A [GeneID=925] dendritic cells: control versus primary acute viral infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
26 M3820 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
27 M8306 Genes down-regulated in activated T cells: CD4 [GeneID=920] versus Va24- NKT. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
28 M7427 Genes up-regulated in the immature neuron cell line: control versus infected with western equine encephalitis viruss. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
29 M3671 Genes down-regulated in comparison of regulatory T cell (Treg) from uninfected mice versus T effector cells from uninfected mice. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
30 M4528 Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
31 M5247 Genes up-regulated in comparison of macrophages exposed to L. major versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.686E-2
2.654E-1
1.000E0
 2 200
32 18281531-Table3 Human Colon Ortega08 12genes GeneSigDB 1.814E-3 4.139E-2
2.981E-1
1.000E0
 1 6
33 M6244 Genes with a high basal transcription state in undifferentiated embryonic carcinoma cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.814E-3 4.139E-2
2.981E-1
1.000E0
 1 6
34 14676830-Table2 Human HeadandNeck Cromer04 8genes GeneSigDB 2.116E-3 4.687E-2
3.375E-1
1.000E0
 1 7
Show 29 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 735 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 30 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 276 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-10a-5p:Functional MTI Functional MTI miRTarbase 8.981E-6 2.479E-3 1.537E-2 2.479E-3 3 463
2 TAATAAT,MIR-126:MSigDB TAATAAT,MIR-126:MSigDB MSigDB 1.667E-4 1.159E-2
7.186E-2
 4.601E-2 2 205
3 hsa-miR-618:PITA hsa-miR-618:PITA TOP PITA 2.865E-4 1.159E-2
7.186E-2
7.909E-2
 2 269
4 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 3.170E-4 1.159E-2
7.186E-2
8.749E-2
 2 283
5 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 3.170E-4 1.159E-2
7.186E-2
8.749E-2
 2 283
6 hsa-miR-1247:mirSVR lowEffct hsa-miR-1247:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.703E-4 1.159E-2
7.186E-2
1.022E-1
 2 306
7 CACTGTG,MIR-128A:MSigDB CACTGTG,MIR-128A:MSigDB MSigDB 3.923E-4 1.159E-2
7.186E-2
1.083E-1
 2 315
8 CACTGTG,MIR-128B:MSigDB CACTGTG,MIR-128B:MSigDB MSigDB 3.923E-4 1.159E-2
7.186E-2
1.083E-1
 2 315
9 hsa-miR-10b-5p:Functional MTI Functional MTI miRTarbase 4.124E-4 1.159E-2
7.186E-2
1.138E-1
 2 323
10 hsa-miR-183-5p.1:TargetScan hsa-miR-183-5p.1 TargetScan 5.344E-4 1.159E-2
7.186E-2
1.475E-1
 2 368
11 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 5.430E-4 1.159E-2
7.186E-2
1.499E-1
 2 371
12 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 5.430E-4 1.159E-2
7.186E-2
1.499E-1
 2 371
13 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 5.460E-4 1.159E-2
7.186E-2
1.507E-1
 2 372
14 hsa-miR-744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.480E-4 1.276E-2
7.910E-2
2.065E-1
 2 436
15 hsa-miR-609:mirSVR highEffct hsa-miR-609:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.686E-4 1.276E-2
7.910E-2
2.121E-1
 2 442
16 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 7.859E-4 1.276E-2
7.910E-2
2.169E-1
 2 447
17 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 7.859E-4 1.276E-2
7.910E-2
2.169E-1
 2 447
18 hsa-miR-1247-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.033E-3 3.118E-2
1.933E-1
5.612E-1
 1 21
19 hsa-miR-127-3p:Functional MTI Functional MTI miRTarbase 2.807E-3 4.077E-2
2.528E-1
7.747E-1
 1 29
20 hsa-miR-5002-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.966E-3 4.230E-2
2.622E-1
1.000E0
 1 41
21 hsa-miR-618:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.352E-3 4.230E-2
2.622E-1
1.000E0
 1 45
22 hsa-miR-27a-5p:Functional MTI Functional MTI miRTarbase 4.352E-3 4.230E-2
2.622E-1
1.000E0
 1 45
23 hsa-miR-296-3p:TargetScan hsa-miR-296-3p TargetScan 4.449E-3 4.230E-2
2.622E-1
1.000E0
 1 46
24 hsa-miR-136-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 4.230E-2
2.622E-1
1.000E0
 1 48
25 hsa-miR-4641:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.028E-3 4.230E-2
2.622E-1
1.000E0
 1 52
26 hsa-miR-4686:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 4.230E-2
2.622E-1
1.000E0
 1 54
27 hsa-miR-582-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 4.230E-2
2.622E-1
1.000E0
 1 55
28 hsa-miR-7155-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 4.230E-2
2.622E-1
1.000E0
 1 56
29 CAAGGAT,MIR-362:MSigDB CAAGGAT,MIR-362:MSigDB MSigDB 5.607E-3 4.230E-2
2.622E-1
1.000E0
 1 58
30 hsa-miR-331-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.089E-3 4.230E-2
2.622E-1
1.000E0
 1 63
31 ATCTTGC,MIR-31:MSigDB ATCTTGC,MIR-31:MSigDB MSigDB 6.282E-3 4.230E-2
2.622E-1
1.000E0
 1 65
32 hsa-miR-8059:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 4.230E-2
2.622E-1
1.000E0
 1 66
33 hsa-miR-4471:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 4.230E-2
2.622E-1
1.000E0
 1 66
34 hsa-miR-3184-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.474E-3 4.230E-2
2.622E-1
1.000E0
 1 67
35 hsa-miR-4678:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.474E-3 4.230E-2
2.622E-1
1.000E0
 1 67
36 hsa-miR-6822-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 4.230E-2
2.622E-1
1.000E0
 1 72
37 hsa-miR-6750-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 4.230E-2
2.622E-1
1.000E0
 1 72
38 hsa-miR-4677-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.149E-3 4.230E-2
2.622E-1
1.000E0
 1 74
39 hsa-miR-6830-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 4.230E-2
2.622E-1
1.000E0
 1 75
40 hsa-miR-885-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 4.230E-2
2.622E-1
1.000E0
 1 77
41 hsa-miR-3688-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.630E-3 4.230E-2
2.622E-1
1.000E0
 1 79
42 hsa-miR-3975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.726E-3 4.230E-2
2.622E-1
1.000E0
 1 80
43 hsa-miR-7153-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 4.230E-2
2.622E-1
1.000E0
 1 83
44 hsa-miR-3130-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 4.230E-2
2.622E-1
1.000E0
 1 83
45 hsa-miR-6072:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 4.230E-2
2.622E-1
1.000E0
 1 84
46 hsa-miR-6891-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.208E-3 4.230E-2
2.622E-1
1.000E0
 1 85
47 hsa-miR-3188:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.304E-3 4.230E-2
2.622E-1
1.000E0
 1 86
48 hsa-miR-2467-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 4.230E-2
2.622E-1
1.000E0
 1 89
49 hsa-miR-1181:mirSVR lowEffct hsa-miR-1181:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.881E-3 4.230E-2
2.622E-1
1.000E0
 1 92
50 hsa-miR-411-5p.2:TargetScan hsa-miR-411-5p.2 TargetScan 9.842E-3 4.230E-2
2.622E-1
1.000E0
 1 102
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1911 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID004630071 AC1NDQQF Stitch 2.660E-7 5.084E-4 4.135E-3 5.084E-4 3 46
2 CID000192085 deltaMID Stitch 2.895E-6 2.766E-3 2.250E-2 5.533E-3 2 9
3 ctd:D009534 Niclosamide CTD 1.966E-5 6.250E-3
5.083E-2
 3.756E-2 3 191
4 632 DN novobiocin sodium, USP; Down 200; 100uM; SKMEL5; HG-U133A Broad Institute CMAP Down 2.091E-5 6.250E-3
5.083E-2
 3.996E-2 3 195
5 335 DN nifedipine; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 2.156E-5 6.250E-3
5.083E-2
 4.120E-2 3 197
6 3246 DN Lactobionic acid [96-82-2]; Down 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.189E-5 6.250E-3
5.083E-2
 4.183E-2 3 198
7 CID000004101 methenamine silver Stitch 2.289E-5 6.250E-3
5.083E-2
 4.375E-2 3 201
8 CID005288255 Fr180204 Stitch 3.488E-5 8.331E-3
6.776E-2
6.665E-2
 2 30
9 CID006102682 F-dd Stitch 2.579E-4 2.806E-2
2.282E-1
4.928E-1
 2 81
10 CID000001694 CK2 inhibitor Stitch 2.975E-4 2.806E-2
2.282E-1
5.685E-1
 2 87
11 CID000166768 p-hydroxymandelonitrile Stitch 5.372E-4 2.806E-2
2.282E-1
1.000E0
 2 117
12 CID015122338 6-chromanol Stitch 6.129E-4 2.806E-2
2.282E-1
1.000E0
 1 2
13 ctd:C493177 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide CTD 9.192E-4 2.806E-2
2.282E-1
1.000E0
 1 3
14 1010 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 9.517E-4 2.806E-2
2.282E-1
1.000E0
 2 156
15 ctd:C016096 N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine CTD 1.225E-3 2.806E-2
2.282E-1
1.000E0
 1 4
16 CID003028528 A-30 Stitch 1.225E-3 2.806E-2
2.282E-1
1.000E0
 1 4
17 CID005280443 apigenin Stitch 1.320E-3 2.806E-2
2.282E-1
1.000E0
 2 184
18 2450 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.806E-2
2.282E-1
1.000E0
 2 192
19 4330 DN PHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.806E-2
2.282E-1
1.000E0
 2 192
20 7232 DN Acenocoumarol [152-72-7]; Down 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.806E-2
2.282E-1
1.000E0
 2 193
21 893 DN pararosaniline base; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.451E-3 2.806E-2
2.282E-1
1.000E0
 2 193
22 2775 UP Epivincamine [6835-99-0]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.465E-3 2.806E-2
2.282E-1
1.000E0
 2 194
23 3988 DN Cinchonine [118-10-5]; Down 200; 13.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.465E-3 2.806E-2
2.282E-1
1.000E0
 2 194
24 582 DN butein; Down 200; 10uM; PC3; HG-U133A Broad Institute CMAP Down 1.465E-3 2.806E-2
2.282E-1
1.000E0
 2 194
25 1730 DN Ethamivan [304-84-7]; Down 200; 18uM; HL60; HG-U133A Broad Institute CMAP Down 1.465E-3 2.806E-2
2.282E-1
1.000E0
 2 194
26 263 UP clofibrate; Up 200; 150uM; MCF7; HG-U133A Broad Institute CMAP Up 1.465E-3 2.806E-2
2.282E-1
1.000E0
 2 194
27 3989 UP Etofenamate [30544-47-9]; Up 200; 10.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.465E-3 2.806E-2
2.282E-1
1.000E0
 2 194
28 7037 UP Adiphenine hydrochloride [50-42-0]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.480E-3 2.806E-2
2.282E-1
1.000E0
 2 195
29 327 UP arachidonyl trifluoromethyl ketone; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Up 1.480E-3 2.806E-2
2.282E-1
1.000E0
 2 195
30 368 UP WY-14643; Up 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Up 1.480E-3 2.806E-2
2.282E-1
1.000E0
 2 195
31 7288 UP Thalidomide [50-35-1]; Up 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.480E-3 2.806E-2
2.282E-1
1.000E0
 2 195
32 898 DN 5213008; Down 200; 18uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.480E-3 2.806E-2
2.282E-1
1.000E0
 2 195
33 1516 DN Loxapine succinate [27833-64-3]; Down 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
34 2406 DN Pinacidil [85371-64-8]; Down 200; 16.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
35 3333 DN Methylhydantoin-5-(D) [55147-68-7]; Down 200; 35uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
36 5261 DN Probucol [23288-49-5]; Down 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
37 5011 DN Famotidine [76824-35-6]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
38 6288 UP Butoconazole nitrate [32872-77-1]; Up 200; 8.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
39 6038 DN Isosorbide dinitrate [87-33-2]; Down 200; 17uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
40 1512 DN Zimelidine dihydrochloride monohydrate [61129-30-4]; Down 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
41 2631 UP Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
42 2168 DN Flunisolide [3385-03-3]; Down 200; 9.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
43 4204 DN Epitiostanol [2363-58-8]; Down 200; 13uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
44 3903 UP Citalopram hydrobromide [59729-32-7]; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
45 5533 UP (-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
46 7495 DN ICI182,780; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
47 2736 DN Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
48 6615 UP Miconazole [22916-47-8]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
49 485 DN deferoxamine mesylate salt; Down 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
50 5569 DN 2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.806E-2
2.282E-1
1.000E0
 2 196
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 201 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0265205 Robinow Syndrome DisGeNET Curated 4.473E-6 8.991E-4 5.289E-3 8.991E-4 2 8
2 C3539781 Progressive cGVHD DisGeNET BeFree 3.521E-5 2.359E-3 1.388E-2 7.077E-3 3 165
3 C0677932 Progressive Neoplastic Disease DisGeNET BeFree 3.521E-5 2.359E-3 1.388E-2 7.077E-3 3 165
4 C4049796 Abnormality of cardiovascular system morphology DisGeNET Curated 1.176E-4 5.911E-3 3.477E-2 2.364E-2 2 39
5 C0334611 Transitional Meningioma DisGeNET BeFree 4.320E-4 9.647E-3
5.675E-2
8.683E-2
 1 1
6 cv:C1842884 Caudal duplication anomaly Clinical Variations 4.320E-4 9.647E-3
5.675E-2
8.683E-2
 1 1
7 OMIN:607864 CAUDAL DUPLICATION ANOMALY OMIM 4.320E-4 9.647E-3
5.675E-2
8.683E-2
 1 1
8 C1842884 Caudal Duplication Anomaly DisGeNET Curated 4.320E-4 9.647E-3
5.675E-2
8.683E-2
 1 1
9 cv:CN229715 ROBINOW SYNDROME, AUTOSOMAL DOMINANT 2 Clinical Variations 4.320E-4 9.647E-3
5.675E-2
8.683E-2
 1 1
10 C0266393 Congenital duplication of uterus DisGeNET Curated 1.295E-3 2.003E-2
1.178E-1
2.604E-1
 1 3
11 C1849343 Bifid terminal phalanges DisGeNET Curated 1.295E-3 2.003E-2
1.178E-1
2.604E-1
 1 3
12 C0035619 Ventricular Outflow Obstruction, Right DisGeNET Curated 1.295E-3 2.003E-2
1.178E-1
2.604E-1
 1 3
13 C4021772 Bifid distal phalanx of toe DisGeNET Curated 1.295E-3 2.003E-2
1.178E-1
2.604E-1
 1 3
14 C4020772 Hypoplastic palate DisGeNET Curated 1.727E-3 2.283E-2
1.343E-1
3.471E-1
 1 4
15 C4023918 Short hard palate DisGeNET Curated 1.727E-3 2.283E-2
1.343E-1
3.471E-1
 1 4
16 C0220650 Metastatic malignant neoplasm to brain DisGeNET BeFree 1.921E-3 2.283E-2
1.343E-1
3.861E-1
 2 158
17 C1865038 Broad toes DisGeNET Curated 2.158E-3 2.283E-2
1.343E-1
4.338E-1
 1 5
18 C1398301 Short palate DisGeNET Curated 2.158E-3 2.283E-2
1.343E-1
4.338E-1
 1 5
19 C0266298 Accessory kidney DisGeNET Curated 2.158E-3 2.283E-2
1.343E-1
4.338E-1
 1 5
20 C0152240 Uterus bilocularis DisGeNET Curated 2.589E-3 2.478E-2
1.458E-1
5.205E-1
 1 6
21 C1849341 Triangular mouth DisGeNET Curated 2.589E-3 2.478E-2
1.458E-1
5.205E-1
 1 6
22 C0238304 Chronic interstitial nephritis DisGeNET Curated 3.451E-3 2.787E-2
1.639E-1
6.937E-1
 1 8
23 C0080276 Disorder of the genitourinary system DisGeNET Curated 3.451E-3 2.787E-2
1.639E-1
6.937E-1
 1 8
24 C0235752 Port-Wine Stain DisGeNET Curated 3.882E-3 2.787E-2
1.639E-1
7.803E-1
 1 9
25 cv:C2239176 Hepatocellular carcinoma Clinical Variations 3.882E-3 2.787E-2
1.639E-1
7.803E-1
 1 9
26 OMIN:114550 HEPATOCELLULAR CARCINOMA OMIM 3.882E-3 2.787E-2
1.639E-1
7.803E-1
 1 9
27 C0549306 Mesomelia DisGeNET Curated 3.882E-3 2.787E-2
1.639E-1
7.803E-1
 1 9
28 C1861901 Subacute progressive viral hepatitis DisGeNET Curated 3.882E-3 2.787E-2
1.639E-1
7.803E-1
 1 9
29 C0221365 Double ureter DisGeNET Curated 5.173E-3 3.466E-2
2.039E-1
1.000E0
 1 12
30 C1274103 Oncogenic osteomalacia DisGeNET BeFree 5.173E-3 3.466E-2
2.039E-1
1.000E0
 1 12
31 C1834060 Short middle phalanx of the 5th finger DisGeNET Curated 5.603E-3 3.519E-2
2.070E-1
1.000E0
 1 13
32 C0267812 Micronodular cirrhosis DisGeNET Curated 5.603E-3 3.519E-2
2.070E-1
1.000E0
 1 13
33 C1844527 Clitoral hypoplasia DisGeNET Curated 6.033E-3 3.675E-2
2.162E-1
1.000E0
 1 14
34 C1266005 Basaloid squamous cell carcinoma DisGeNET BeFree 6.463E-3 3.711E-2
2.183E-1
1.000E0
 1 15
35 C3542024 AORTIC VALVE DISEASE 2 DisGeNET Curated 6.463E-3 3.711E-2
2.183E-1
1.000E0
 1 15
36 C0566899 Small labia majora DisGeNET Curated 6.892E-3 3.744E-2
2.203E-1
1.000E0
 1 16
37 C0013261 Duane Retraction Syndrome DisGeNET Curated 6.892E-3 3.744E-2
2.203E-1
1.000E0
 1 16
38 C0013069 Double Outlet Right Ventricle DisGeNET Curated 7.322E-3 3.773E-2
2.220E-1
1.000E0
 1 17
39 C1849340 Long palpebral fissure DisGeNET Curated 7.322E-3 3.773E-2
2.220E-1
1.000E0
 1 17
40 C0751587 CADASIL Syndrome DisGeNET Curated 8.180E-3 4.110E-2
2.418E-1
1.000E0
 1 19
41 C0029182 orbit (eye disorders) DisGeNET BeFree 9.895E-3 4.838E-2
2.846E-1
1.000E0
 1 23
42 C0022575 Keratoconjunctivitis Sicca DisGeNET Curated 1.032E-2 4.838E-2
2.846E-1
1.000E0
 1 24
43 C3536984 Vitamin D-Resistant Rickets, X-Linked DisGeNET BeFree 1.075E-2 4.838E-2
2.846E-1
1.000E0
 1 25
44 C0032580 Adenomatous Polyposis Coli DisGeNET Curated 1.098E-2 4.838E-2
2.846E-1
1.000E0
 2 386
45 C1333977 Hepatitis B Virus-Related Hepatocellular Carcinoma DisGeNET BeFree 1.161E-2 4.838E-2
2.846E-1
1.000E0
 1 27
46 C1867955 Increased incidence of hepatocellular carcinoma DisGeNET Curated 1.161E-2 4.838E-2
2.846E-1
1.000E0
 1 27
47 C1862761 Increased hepatocellular carcinoma risk DisGeNET Curated 1.161E-2 4.838E-2
2.846E-1
1.000E0
 1 27
48 C1332850 Cardiac Lymphoma DisGeNET BeFree 1.203E-2 4.838E-2
2.846E-1
1.000E0
 1 28
49 C0733682 Hypophosphatemic Rickets, X-Linked Dominant DisGeNET Curated 1.203E-2 4.838E-2
2.846E-1
1.000E0
 1 28
50 C0426891 Broad thumbs DisGeNET Curated 1.203E-2 4.838E-2
2.846E-1
1.000E0
 1 28
Show 45 more annotations