Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc132_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 35 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 4.016E-4 8.250E-3 3.421E-2 1.405E-2 3 259
2 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.022E-3 8.250E-3 3.421E-2 3.577E-2 3 357
3 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 1.090E-3 8.250E-3 3.421E-2 3.814E-2 3 365
4 GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity 1.179E-3 8.250E-3 3.421E-2 4.125E-2 1 2
5 GO:0004692 cGMP-dependent protein kinase activity 1.179E-3 8.250E-3 3.421E-2 4.125E-2 1 2
6 GO:0001134 transcription regulator recruiting activity 2.944E-3 1.717E-2
7.122E-2
1.030E-1
 1 5
7 GO:0048273 mitogen-activated protein kinase p38 binding 3.532E-3 1.766E-2
7.323E-2
1.236E-1
 1 6
8 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5.294E-3 2.316E-2
9.604E-2
1.853E-1
 1 9
9 GO:0004690 cyclic nucleotide-dependent protein kinase activity 9.394E-3 3.492E-2
1.448E-1
3.288E-1
 1 16
10 GO:0030553 cGMP binding 9.978E-3 3.492E-2
1.448E-1
3.492E-1
 1 17
Show 5 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 462 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071409 cellular response to cycloheximide 9.513E-7 4.395E-4 2.951E-3 4.395E-4 2 3
2 GO:0046898 response to cycloheximide 6.650E-6 1.536E-3 1.031E-2 3.072E-3 2 7
3 GO:0045444 fat cell differentiation 2.673E-4 3.409E-2
2.289E-1
1.235E-1
 3 225
4 GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell 5.907E-4 3.409E-2
2.289E-1
2.729E-1
 1 1
5 GO:0071300 cellular response to retinoic acid 7.926E-4 3.409E-2
2.289E-1
3.662E-1
 2 72
6 GO:0003300 cardiac muscle hypertrophy 7.926E-4 3.409E-2
2.289E-1
3.662E-1
 2 72
7 GO:0014897 striated muscle hypertrophy 8.597E-4 3.409E-2
2.289E-1
3.972E-1
 2 75
8 GO:1901653 cellular response to peptide 8.926E-4 3.409E-2
2.289E-1
4.124E-1
 3 340
9 GO:0014896 muscle hypertrophy 9.059E-4 3.409E-2
2.289E-1
4.185E-1
 2 77
10 GO:0010920 negative regulation of inositol phosphate biosynthetic process 1.181E-3 3.409E-2
2.289E-1
5.456E-1
 1 2
11 GO:0014740 negative regulation of muscle hyperplasia 1.181E-3 3.409E-2
2.289E-1
5.456E-1
 1 2
12 GO:0061757 leukocyte adhesion to arterial endothelial cell 1.181E-3 3.409E-2
2.289E-1
5.456E-1
 1 2
13 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production 1.181E-3 3.409E-2
2.289E-1
5.456E-1
 1 2
14 GO:1904997 regulation of leukocyte adhesion to arterial endothelial cell 1.181E-3 3.409E-2
2.289E-1
5.456E-1
 1 2
15 GO:1901655 cellular response to ketone 1.208E-3 3.409E-2
2.289E-1
5.580E-1
 2 89
16 GO:0070301 cellular response to hydrogen peroxide 1.235E-3 3.409E-2
2.289E-1
5.705E-1
 2 90
17 GO:0043500 muscle adaptation 1.552E-3 3.409E-2
2.289E-1
7.168E-1
 2 101
18 GO:0003012 muscle system process 1.757E-3 3.409E-2
2.289E-1
8.117E-1
 3 430
19 GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity 1.771E-3 3.409E-2
2.289E-1
8.182E-1
 1 3
20 GO:2000224 regulation of testosterone biosynthetic process 1.771E-3 3.409E-2
2.289E-1
8.182E-1
 1 3
21 GO:0046985 positive regulation of hemoglobin biosynthetic process 1.771E-3 3.409E-2
2.289E-1
8.182E-1
 1 3
22 GO:0014738 regulation of muscle hyperplasia 1.771E-3 3.409E-2
2.289E-1
8.182E-1
 1 3
23 GO:1902606 regulation of large conductance calcium-activated potassium channel activity 1.771E-3 3.409E-2
2.289E-1
8.182E-1
 1 3
24 GO:0007500 mesodermal cell fate determination 1.771E-3 3.409E-2
2.289E-1
8.182E-1
 1 3
25 GO:0014900 muscle hyperplasia 2.361E-3 3.900E-2
2.618E-1
1.000E0
 1 4
26 GO:0045415 negative regulation of interleukin-8 biosynthetic process 2.361E-3 3.900E-2
2.618E-1
1.000E0
 1 4
27 GO:0032526 response to retinoic acid 2.363E-3 3.900E-2
2.618E-1
1.000E0
 2 125
28 GO:1901652 response to peptide 2.363E-3 3.900E-2
2.618E-1
1.000E0
 3 477
29 GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell 2.950E-3 4.322E-2
2.902E-1
1.000E0
 1 5
30 GO:0048386 positive regulation of retinoic acid receptor signaling pathway 2.950E-3 4.322E-2
2.902E-1
1.000E0
 1 5
31 GO:0046984 regulation of hemoglobin biosynthetic process 2.950E-3 4.322E-2
2.902E-1
1.000E0
 1 5
32 GO:0097306 cellular response to alcohol 2.994E-3 4.322E-2
2.902E-1
1.000E0
 2 141
33 GO:0042542 response to hydrogen peroxide 3.205E-3 4.419E-2
2.967E-1
1.000E0
 2 146
34 GO:0034614 cellular response to reactive oxygen species 3.336E-3 4.419E-2
2.967E-1
1.000E0
 2 149
35 GO:0051099 positive regulation of binding 3.468E-3 4.419E-2
2.967E-1
1.000E0
 2 152
36 GO:0061370 testosterone biosynthetic process 3.539E-3 4.419E-2
2.967E-1
1.000E0
 1 6
37 GO:0035166 post-embryonic hemopoiesis 3.539E-3 4.419E-2
2.967E-1
1.000E0
 1 6
38 GO:0022408 negative regulation of cell-cell adhesion 3.695E-3 4.492E-2
3.016E-1
1.000E0
 2 157
39 GO:0032534 regulation of microvillus assembly 4.128E-3 4.842E-2
3.251E-1
1.000E0
 1 7
40 GO:0070587 regulation of cell-cell adhesion involved in gastrulation 4.716E-3 4.842E-2
3.251E-1
1.000E0
 1 8
41 GO:0060087 relaxation of vascular smooth muscle 4.716E-3 4.842E-2
3.251E-1
1.000E0
 1 8
42 GO:2000774 positive regulation of cellular senescence 4.716E-3 4.842E-2
3.251E-1
1.000E0
 1 8
43 GO:0014745 negative regulation of muscle adaptation 4.716E-3 4.842E-2
3.251E-1
1.000E0
 1 8
44 GO:0034115 negative regulation of heterotypic cell-cell adhesion 4.716E-3 4.842E-2
3.251E-1
1.000E0
 1 8
45 GO:0071499 cellular response to laminar fluid shear stress 4.716E-3 4.842E-2
3.251E-1
1.000E0
 1 8
46 GO:1903035 negative regulation of response to wounding 5.089E-3 4.901E-2
3.291E-1
1.000E0
 2 185
47 GO:0031077 post-embryonic camera-type eye development 5.305E-3 4.901E-2
3.291E-1
1.000E0
 1 9
48 GO:0014050 negative regulation of glutamate secretion 5.305E-3 4.901E-2
3.291E-1
1.000E0
 1 9
49 GO:0070586 cell-cell adhesion involved in gastrulation 5.305E-3 4.901E-2
3.291E-1
1.000E0
 1 9
50 GO:0035563 positive regulation of chromatin binding 5.305E-3 4.901E-2
3.291E-1
1.000E0
 1 9
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 12 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 3 input genes in category / 98 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 11 input genes in category / 529 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0013527 absent conjunctiva goblet cells 1.026E-6 5.427E-4 3.717E-3 5.427E-4 2 2
2 MP:0013464 decreased conjunctiva goblet cell number 1.024E-5 1.354E-3 9.277E-3 5.418E-3 2 5
3 MP:0013462 abnormal conjunctiva goblet cell number 1.024E-5 1.354E-3 9.277E-3 5.418E-3 2 5
4 MP:0001320 small pupils 1.024E-5 1.354E-3 9.277E-3 5.418E-3 2 5
5 MP:0009742 increased corneal stroma thickness 2.863E-5 3.029E-3 2.074E-2 1.514E-2 2 8
6 MP:0012164 abnormal conjunctiva goblet cell morphology 3.679E-5 3.243E-3 2.221E-2 1.946E-2 2 9
7 MP:0004481 abnormal conjunctival epithelium morphology 6.732E-5 5.088E-3 3.485E-2 3.561E-2 2 12
8 MP:0020855 decreased corneal epithelium thickness 9.272E-5 5.450E-3 3.733E-2 4.905E-2 2 14
9 MP:0003092 decreased corneal stroma thickness 9.272E-5 5.450E-3 3.733E-2 4.905E-2 2 14
10 MP:0001310 abnormal conjunctiva morphology 1.383E-4 7.317E-3
5.012E-2
7.317E-2
 2 17
11 MP:0001163 abnormal prostate gland anterior lobe morphology 1.929E-4 9.277E-3
6.354E-2
1.020E-1
 2 20
12 MP:0005176 eyelids fail to open 2.564E-4 1.043E-2
7.147E-2
1.357E-1
 2 23
13 MP:0020853 abnormal corneal epithelium thickness 2.564E-4 1.043E-2
7.147E-2
1.357E-1
 2 23
14 MP:0005543 decreased cornea thickness 4.391E-4 1.659E-2
1.136E-1
2.323E-1
 2 30
15 MP:0011961 abnormal cornea thickness 7.441E-4 2.624E-2
1.797E-1
3.936E-1
 2 39
16 MP:0005300 abnormal corneal stroma morphology 9.047E-4 2.676E-2
1.833E-1
4.786E-1
 2 43
17 MP:0010786 stomach fundus hypertrophy 1.062E-3 2.676E-2
1.833E-1
5.620E-1
 1 1
18 MP:0020862 increased cornea fragility 1.062E-3 2.676E-2
1.833E-1
5.620E-1
 1 1
19 MP:0010203 focal ventral hair loss 1.062E-3 2.676E-2
1.833E-1
5.620E-1
 1 1
20 MP:0030577 increased keratinocyte adhesion 1.062E-3 2.676E-2
1.833E-1
5.620E-1
 1 1
21 MP:0014147 lacrimal gland necrosis 1.062E-3 2.676E-2
1.833E-1
5.620E-1
 1 1
22 MP:0013327 abnormal male reproductive gland physiology 1.174E-3 2.700E-2
1.850E-1
6.211E-1
 2 49
23 MP:0006000 abnormal corneal epithelium morphology 1.174E-3 2.700E-2
1.850E-1
6.211E-1
 2 49
24 MP:0000496 abnormal small intestine morphology 1.358E-3 2.993E-2
2.050E-1
7.184E-1
 3 219
25 MP:0001317 abnormal pupil morphology 1.477E-3 3.126E-2
2.141E-1
7.816E-1
 2 55
26 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology 1.586E-3 3.203E-2
2.194E-1
8.390E-1
 2 57
27 MP:0002840 abnormal lens fiber morphology 1.642E-3 3.203E-2
2.194E-1
8.685E-1
 2 58
28 MP:0009866 abnormal aorta wall morphology 1.756E-3 3.203E-2
2.194E-1
9.289E-1
 2 60
29 MP:0001306 small lens 1.756E-3 3.203E-2
2.194E-1
9.289E-1
 2 60
30 MP:0010778 abnormal stomach fundus morphology 2.124E-3 3.304E-2
2.263E-1
1.000E0
 1 2
31 MP:0008521 abnormal Bowman membrane 2.124E-3 3.304E-2
2.263E-1
1.000E0
 1 2
32 MP:0013394 abnormal palpebral conjunctiva morphology 2.124E-3 3.304E-2
2.263E-1
1.000E0
 1 2
33 MP:0011482 posterior iris synechia 2.124E-3 3.304E-2
2.263E-1
1.000E0
 1 2
34 MP:0013385 abnormal Meibomian gland development 2.124E-3 3.304E-2
2.263E-1
1.000E0
 1 2
35 MP:0004874 abnormal timing of postnatal eyelid opening 2.249E-3 3.400E-2
2.329E-1
1.000E0
 2 68
36 MP:0001158 abnormal prostate gland morphology 2.801E-3 4.010E-2
2.747E-1
1.000E0
 2 76
37 MP:0013754 abnormal ocular surface morphology 3.175E-3 4.010E-2
2.747E-1
1.000E0
 2 81
38 MP:0004216 salt-resistant hypertension 3.184E-3 4.010E-2
2.747E-1
1.000E0
 1 3
39 MP:0003093 abnormal cornea anterior stroma morphology 3.184E-3 4.010E-2
2.747E-1
1.000E0
 1 3
40 MP:0000765 abnormal tongue squamous epithelium morphology 3.184E-3 4.010E-2
2.747E-1
1.000E0
 1 3
41 MP:0013391 abnormal Meibomian gland physiology 3.184E-3 4.010E-2
2.747E-1
1.000E0
 1 3
42 MP:0013765 iris hyperplasia 3.184E-3 4.010E-2
2.747E-1
1.000E0
 1 3
43 MP:0005647 abnormal sex gland physiology 3.410E-3 4.196E-2
2.874E-1
1.000E0
 2 84
44 MP:0004264 abnormal extraembryonic tissue physiology 4.082E-3 4.235E-2
2.901E-1
1.000E0
 3 322
45 MP:0012101 acoria 4.243E-3 4.235E-2
2.901E-1
1.000E0
 1 4
46 MP:0010781 pyloric sphincter hypertrophy 4.243E-3 4.235E-2
2.901E-1
1.000E0
 1 4
47 MP:0011163 increased wet-to-dry lung weight ratio 4.243E-3 4.235E-2
2.901E-1
1.000E0
 1 4
48 MP:0009935 abnormal Meibomian gland acinus morphology 4.243E-3 4.235E-2
2.901E-1
1.000E0
 1 4
49 MP:0012117 decreased trophectoderm cell proliferation 4.243E-3 4.235E-2
2.901E-1
1.000E0
 1 4
50 MP:0009326 absent maternal crouching 4.243E-3 4.235E-2
2.901E-1
1.000E0
 1 4
Show 45 more annotations

6: Domain [Display Chart] 11 input genes in category / 50 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR031831 PKcGMP CC InterPro 5.871E-4 1.067E-2 4.799E-2 2.936E-2 1 1
2 PF16808 PKcGMP CC Pfam 5.871E-4 1.067E-2 4.799E-2 2.936E-2 1 1
3 IPR002374 cGMP dep kinase InterPro 1.174E-3 1.067E-2 4.799E-2
5.870E-2
 1 2
4 IPR033237 BRINP InterPro 1.760E-3 1.067E-2 4.799E-2
8.802E-2
 1 3
5 IPR029753 D-isomer DH CS InterPro 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
6 PS00065 D 2 HYDROXYACID DH 1 PROSITE 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
7 PF02826 2-Hacid dh C Pfam 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
8 PS00671 D 2 HYDROXYACID DH 3 PROSITE 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
9 PS00670 D 2 HYDROXYACID DH 2 PROSITE 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
10 IPR006139 D-isomer 2 OHA DH cat dom InterPro 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
11 PF00389 2-Hacid dh Pfam 2.347E-3 1.067E-2 4.799E-2
1.173E-1
 1 4
12 IPR006140 D-isomer DH NAD-bd InterPro 2.933E-3 1.128E-2
5.075E-2
1.466E-1
 1 5
13 PS51792 YIPPEE PROSITE 2.933E-3 1.128E-2
5.075E-2
1.466E-1
 1 5
14 PF03226 Yippee-Mis18 Pfam 4.688E-3 1.563E-2
7.031E-2
2.344E-1
 1 8
15 IPR004910 Yippee/Mis18/Cereblon InterPro 4.688E-3 1.563E-2
7.031E-2
2.344E-1
 1 8
16 IPR001862 MAC perforin InterPro 5.857E-3 1.830E-2
8.235E-2
2.929E-1
 1 10
17 PF01823 MACPF Pfam 6.441E-3 1.849E-2
8.318E-2
3.221E-1
 1 11
18 IPR020864 MACPF InterPro 7.025E-3 1.849E-2
8.318E-2
3.512E-1
 1 12
19 SM00457 MACPF SMART 7.025E-3 1.849E-2
8.318E-2
3.512E-1
 1 12
20 IPR018488 cNMP-bd CS InterPro 9.357E-3 2.339E-2
1.052E-1
4.678E-1
 1 16
21 IPR027775 C2H2 Znf fam InterPro 1.401E-2 3.183E-2
1.432E-1
7.003E-1
 1 24
22 IPR010978 tRNA-bd arm InterPro 1.401E-2 3.183E-2
1.432E-1
7.003E-1
 1 24
23 PS00888 CNMP BINDING 1 PROSITE 1.863E-2 3.636E-2
1.636E-1
9.317E-1
 1 32
24 PS00889 CNMP BINDING 2 PROSITE 1.863E-2 3.636E-2
1.636E-1
9.317E-1
 1 32
25 PF00027 cNMP binding Pfam 1.979E-2 3.636E-2
1.636E-1
9.894E-1
 1 34
26 SM00100 cNMP SMART 1.979E-2 3.636E-2
1.636E-1
9.894E-1
 1 34
27 IPR000595 cNMP-bd dom InterPro 2.036E-2 3.636E-2
1.636E-1
1.000E0
 1 35
28 PS50042 CNMP BINDING 3 PROSITE 2.036E-2 3.636E-2
1.636E-1
1.000E0
 1 35
29 IPR018490 cNMP-bd-like InterPro 2.209E-2 3.809E-2
1.714E-1
1.000E0
 1 38
30 2.60.120.10 - Gene3D 2.783E-2 4.373E-2
1.968E-1
1.000E0
 1 48
31 IPR014710 RmlC-like jellyroll InterPro 2.955E-2 4.373E-2
1.968E-1
1.000E0
 1 51
32 SM00133 S TK X SMART 3.240E-2 4.373E-2
1.968E-1
1.000E0
 1 56
33 PS51285 AGC KINASE CTER PROSITE 3.240E-2 4.373E-2
1.968E-1
1.000E0
 1 56
34 IPR000961 AGC-kinase C InterPro 3.240E-2 4.373E-2
1.968E-1
1.000E0
 1 56
35 SM00431 SCAN SMART 3.240E-2 4.373E-2
1.968E-1
1.000E0
 1 56
36 IPR003309 SCAN dom InterPro 3.354E-2 4.373E-2
1.968E-1
1.000E0
 1 58
37 PS50804 SCAN BOX PROSITE 3.354E-2 4.373E-2
1.968E-1
1.000E0
 1 58
38 PF02023 SCAN Pfam 3.354E-2 4.373E-2
1.968E-1
1.000E0
 1 58
39 IPR008916 Retrov capsid C InterPro 3.411E-2 4.373E-2
1.968E-1
1.000E0
 1 59
Show 34 more annotations

7: Pathway [Display Chart] 7 input genes in category / 39 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270345 Transcriptional regulation of white adipocyte differentiation BioSystems: REACTOME 1.014E-3 3.288E-2
1.398E-1
 3.953E-2 2 88
2 1268922 TCF7L2 mutants don't bind CTBP BioSystems: REACTOME 1.686E-3 3.288E-2
1.398E-1
6.575E-2
 1 3

8: Pubmed [Display Chart] 11 input genes in category / 1778 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15820306 Mammalian SP/KLF transcription factors: bring in the family. Pubmed 1.440E-17 2.561E-14 2.064E-13 2.561E-14 6 24
2 15937668 Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes. Pubmed 5.399E-16 4.800E-13 3.869E-12 9.600E-13 5 12
3 27743478 Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Pubmed 3.721E-12 2.205E-9 1.778E-8 6.616E-9 4 14
4 17688680 Analysis of KLF transcription factor family gene variants in type 2 diabetes. Pubmed 1.777E-10 6.317E-8 5.092E-7 3.159E-7 3 5
5 25652467 Krüppel-like factors in hepatocellular carcinoma. Pubmed 1.777E-10 6.317E-8 5.092E-7 3.159E-7 3 5
6 23134681 Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. Pubmed 3.553E-10 1.053E-7 8.486E-7 6.316E-7 3 6
7 22538816 KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
8 15740636 Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
9 26212907 Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
10 26097551 Krüppel-like factors 4 and 5 expression and their involvement in differentiation of oral carcinomas. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
11 17508399 The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
12 24770696 Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
13 19268913 Spatial and temporal expression of KLF4 and KLF5 during murine tooth development. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
14 10756197 Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
15 10802067 The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
16 10767086 Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
17 21674249 Association of expression of kruppel-like factor 4 and kruppel-like factor 5 with the clinical manifestations of breast cancer. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
18 12901861 Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
19 12087155 Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Pubmed 7.541E-8 7.057E-6 5.688E-5 1.341E-4 2 2
20 20709022 Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
21 29739838 Overlapping functions of Krüppel-like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
22 27199507 Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
23 27629257 miR-4262 Promotes Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting KLF6 and KLF15. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
24 16632465 Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
25 28849090 Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting krüppel-like factor 4/5. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
26 25789974 Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. Pubmed 2.262E-7 1.547E-5 1.247E-4 4.022E-4 2 3
27 18264089 A core Klf circuitry regulates self-renewal of embryonic stem cells. Pubmed 4.523E-7 2.594E-5 2.091E-4 8.042E-4 2 4
28 21470678 Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Pubmed 4.523E-7 2.594E-5 2.091E-4 8.042E-4 2 4
29 12556451 The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2. Pubmed 4.523E-7 2.594E-5 2.091E-4 8.042E-4 2 4
30 16023392 A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element. Pubmed 4.523E-7 2.594E-5 2.091E-4 8.042E-4 2 4
31 24626089 KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Pubmed 4.523E-7 2.594E-5 2.091E-4 8.042E-4 2 4
32 26178595 EphA7 regulates spiral ganglion innervation of cochlear hair cells. Pubmed 7.538E-7 3.942E-5 3.177E-4 1.340E-3 2 5
33 11472850 Embryonic expression of Krüppel-like factor 6 in neural and non-neural tissues. Pubmed 7.538E-7 3.942E-5 3.177E-4 1.340E-3 2 5
34 26771354 BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors. Pubmed 7.538E-7 3.942E-5 3.177E-4 1.340E-3 2 5
35 16615998 Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Pubmed 1.130E-6 5.432E-5 4.379E-4 2.010E-3 2 6
36 21600198 Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Pubmed 1.130E-6 5.432E-5 4.379E-4 2.010E-3 2 6
37 26226504 Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. Pubmed 1.130E-6 5.432E-5 4.379E-4 2.010E-3 2 6
38 22307056 ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Pubmed 1.582E-6 7.404E-5 5.968E-4 2.813E-3 2 7
39 26979619 Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential. Pubmed 2.712E-6 1.236E-4 9.966E-4 4.822E-3 2 9
40 21056461 Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Pubmed 4.969E-6 2.155E-4 1.737E-3 8.835E-3 2 12
41 20378849 MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Pubmed 4.969E-6 2.155E-4 1.737E-3 8.835E-3 2 12
42 20439489 miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Pubmed 5.540E-6 2.345E-4 1.890E-3 9.849E-3 3 125
43 24146773 The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. Pubmed 1.680E-5 6.945E-4 5.598E-3 2.986E-2 3 181
44 16230531 Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Pubmed 2.637E-5 7.747E-4 6.245E-3 4.688E-2 2 27
45 24550112 Sall1 balances self-renewal and differentiation of renal progenitor cells. Pubmed 1.553E-4 7.747E-4 6.245E-3
2.761E-1
 2 65
46 16385451 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Pubmed 1.984E-4 7.747E-4 6.245E-3
3.527E-1
 3 416
47 26995652 KLF8 knockdown triggered growth inhibition and induced cell phase arrest in human pancreatic cancer cells. Pubmed 2.880E-4 7.747E-4 6.245E-3
5.121E-1
 1 1
48 24927920 Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation. Pubmed 2.880E-4 7.747E-4 6.245E-3
5.121E-1
 1 1
49 18443297 Anemia and splenomegaly in cGKI-deficient mice. Pubmed 2.880E-4 7.747E-4 6.245E-3
5.121E-1
 1 1
50 24018236 Epigenetic inactivation of KLF4 is associated with urothelial cancer progression and early recurrence. Pubmed 2.880E-4 7.747E-4 6.245E-3
5.121E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 302 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KLF8 KLF8 interactions 4.192E-5 1.099E-2
6.914E-2
 1.266E-2 2 16
2 int:KLF6 KLF6 interactions 8.818E-5 1.099E-2
6.914E-2
 2.663E-2 2 23
3 int:FHL3 FHL3 interactions 1.092E-4 1.099E-2
6.914E-2
 3.298E-2 3 158
4 int:CTBP1 CTBP1 interactions 2.097E-4 1.170E-2
7.357E-2
6.332E-2
 3 197
5 int:KLF4 KLF4 interactions 2.186E-4 1.170E-2
7.357E-2
6.602E-2
 2 36
6 int:KAT2B KAT2B interactions 2.324E-4 1.170E-2
7.357E-2
7.018E-2
 3 204
7 int:LCOR LCOR interactions 8.521E-4 3.676E-2
2.312E-1
2.573E-1
 2 71
8 int:ZNF750 ZNF750 interactions 1.242E-3 4.169E-2
2.622E-1
3.752E-1
 1 2
9 int:TRIM39-RPP21 TRIM39-RPP21 interactions 1.242E-3 4.169E-2
2.622E-1
3.752E-1
 1 2
10 int:HDAC2 HDAC2 interactions 1.403E-3 4.236E-2
2.664E-1
4.236E-1
 3 378
11 int:CREBBP CREBBP interactions 1.627E-3 4.467E-2
2.809E-1
4.913E-1
 3 398
12 int:SMPDL3A SMPDL3A interactions 1.863E-3 4.689E-2
2.949E-1
5.626E-1
 1 3
Show 7 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9q32-q33 9q32-q33 9.518E-4 1.045E-2 3.155E-2 1.047E-2 1 3
2 10p15 10p15 2.220E-3 1.045E-2 3.155E-2 2.442E-2 1 7
3 13q22.1 13q22.1 4.119E-3 1.045E-2 3.155E-2 4.530E-2 1 13
4 10q11.2 10q11.2 5.383E-3 1.045E-2 3.155E-2
5.921E-2
 1 17
5 9q31 9q31 5.383E-3 1.045E-2 3.155E-2
5.921E-2
 1 17
6 2p25 2p25 5.698E-3 1.045E-2 3.155E-2
6.268E-2
 1 18
7 Xp11.21 Xp11.21 1.105E-2 1.737E-2
5.245E-2
1.216E-1
 1 35
8 10q26.13 10q26.13 1.294E-2 1.779E-2
5.372E-2
1.423E-1
 1 41
9 3q21.3 3q21.3 1.669E-2 2.040E-2
6.162E-2
1.836E-1
 1 53
10 19q13.4 19q13.4 2.510E-2 2.761E-2
8.338E-2
2.761E-1
 1 80
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 122 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 624 Zinc fingers C2H2-type|Kruppel like factors genenames.org 1.031E-17 2.063E-17 3.094E-17 2.063E-17 6 18
2 1130 Yippee like family genenames.org 2.197E-3 2.197E-3 3.295E-3 4.394E-3 1 5

13: Coexpression [Display Chart] 11 input genes in category / 1406 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5888 Cluster 2: late ATM [GeneID=472] dependent genes induced by ionizing radiation treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.581E-5 2.338E-2
1.829E-1
 3.628E-2 3 127
2 M17923 Genes up-regulated in cultured stromal stem cells from adipose tissue, compared to the freshly isolated cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.344E-5 2.338E-2
1.829E-1
 4.702E-2 4 425
3 M9086 Genes down-regulated in CD4 T conv: control versus over-expression of IRF4 [GeneID=3662]. MSigDB C7: Immunologic Signatures (v6.0) 5.141E-5 2.338E-2
1.829E-1
7.229E-2
 3 160
4 M2861 Genes down-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 9.114E-5 2.338E-2
1.829E-1
1.281E-1
 3 194
5 M4460 Genes up-regulated in comparison of monocytes cultured for 0 days versus those cultured for 7 days. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 2.338E-2
1.829E-1
1.403E-1
 3 200
6 M4472 Genes down-regulated in comparison of dendritic cells (DC) versus monocytes. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 2.338E-2
1.829E-1
1.403E-1
 3 200
7 M16637 Genes up-regulated in HET1A cells (esophagus epithelium) engineered to stably express CDX2 [GeneID=1045]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.283E-4 2.577E-2
2.017E-1
1.804E-1
 2 36
8 M15383 Supplementary Table 2. Genelist comparing microarray expression profiles of spermatogonial cells, haGSCs and hES (H1) cells. Examples of expression rates of different hES cell enriched and germ cell specific genes, surface markers for germ cell selection and signal transduction in all three cell types (spermatogonial cells = SC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.508E-4 2.651E-2
2.074E-1
2.120E-1
 2 39
9 M10253 Genes down-regulated in NIH3T3 cells (fibroblasts) after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins; the changes did not depend on expression of constitutively active (Q63L) form of RHOA [GeneID=387]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.290E-4 3.365E-2
2.633E-1
3.220E-1
 2 48
10 18310505-TableS8 Human StemCell Matushansky08 297genes GeneSigDB 2.393E-4 3.365E-2
2.633E-1
3.365E-1
 3 269
11 M19766 Genes silenced by DNA methylation in bladder cancer cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.010E-4 3.405E-2
2.665E-1
4.232E-1
 2 55
12 M1914 Genes up-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.076E-4 3.405E-2
2.665E-1
4.325E-1
 3 293
13 M2700 Genes down-regulated in bone relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.768E-4 3.405E-2
2.665E-1
5.298E-1
 3 314
14 M9775 Genes up-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.077E-4 3.405E-2
2.665E-1
5.732E-1
 2 64
15 M15821 Genes whose expression peaked at 120 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.205E-4 3.405E-2
2.665E-1
5.912E-1
 2 65
16 M12353 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to other thyroid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.335E-4 3.405E-2
2.665E-1
6.095E-1
 2 66
17 M2012 Genes up-regulated in mARMS (molecular ARMS) compared to the mERMS (molecular ERMS) class of rhabdomyosarcoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.396E-4 3.405E-2
2.665E-1
6.181E-1
 3 331
18 M13879 Genes down-regulated in uterine fibroids vs normal myometrium samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.467E-4 3.405E-2
2.665E-1
6.281E-1
 2 67
19 15940248-Table3 Human Uterine Vanharanta05 79genes GeneSigDB 4.602E-4 3.405E-2
2.665E-1
6.470E-1
 2 68
20 20096135-Table2 Human Liver Utispan10 75genes GeneSigDB 5.016E-4 3.421E-2
2.677E-1
7.052E-1
 2 71
21 M6315 Cluster 2: genes down-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.305E-4 3.421E-2
2.677E-1
7.459E-1
 3 353
22 M4605 Genes up-regulated in follicular thyroid adenoma (FTA) compared to other thyroid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.595E-4 3.421E-2
2.677E-1
7.867E-1
 2 75
23 M1600 Genes up-regulated in the nucleus accumbens (a major reward center in the brain) after 4 weeks of cocaine [PubChem=5760] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.595E-4 3.421E-2
2.677E-1
7.867E-1
 2 75
24 15940248-SuppTable1 Human Uterine Vanharanta05 737genes GeneSigDB 6.523E-4 3.759E-2
2.942E-1
9.171E-1
 2 81
25 18006806-TableS2 Human Prostate Yu07 87genes GeneSigDB 6.684E-4 3.759E-2
2.942E-1
9.398E-1
 2 82
26 M14650 Genes down-regulated in primary keratinocytes by expression of constantly active NOTCH1 [GeneID=4851]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.349E-4 3.974E-2
3.110E-1
1.000E0
 2 86
27 M11288 Genes bearing H3K27me3 mark or whose promoters are bound by the polycomb proteins SUZ12 or EED [GeneID=23512;8726]; their DNA is methylated de novo in cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.693E-4 4.006E-2
3.135E-1
1.000E0
 2 88
28 19123479-TableS1 Human StemCell Colombo09 111genes GeneSigDB 8.403E-4 4.220E-2
3.302E-1
1.000E0
 2 92
29 M9673 Genes up-regulated in macrophages by P.gingivalis LPS (lipopolysaccharide). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.286E-4 4.357E-2
3.410E-1
1.000E0
 3 428
30 20032505-TableS7 Human Leukemia Stam09 150genes Figure5 GeneSigDB 9.721E-4 4.357E-2
3.410E-1
1.000E0
 2 99
31 20032505-TableS8 Human Leukemia Stam09 150genes Figure6 GeneSigDB 9.721E-4 4.357E-2
3.410E-1
1.000E0
 2 99
32 M14079 Breast cancer compendium: 100 transcription regulators showing most correlated expression with the 9 'embryonic stem cell' transcription factors that are preferentially and coordinately overexpressed in the high-grade, ER-negative breast cancer tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.917E-4 4.357E-2
3.410E-1
1.000E0
 2 100
33 16778185-Table1 Human Leukemia Gebhard06 131genes GeneSigDB 1.092E-3 4.612E-2
3.610E-1
1.000E0
 2 105
34 17683608-TableS5 Mouse StemCell Ulloa-Montoya07 530genes GeneSigDB 1.115E-3 4.612E-2
3.610E-1
1.000E0
 3 456
35 M4785 Genes down-regulated in monocyte-derived dendritic cells (MDDC) after stimulation with galecin-1 (lectin, LGALS1) [GeneID=3956] compared to that with bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.166E-3 4.678E-2
3.661E-1
1.000E0
 3 463
36 17430594-table4 Human Prostate Chandran07 154genes GeneSigDB 1.198E-3 4.678E-2
3.661E-1
1.000E0
 2 110
37 M19068 Genes present but differentially expressed between Hep3B cells (hepatocellular carcinoma, HCC) with RNAi knockdown of SDHB [GeneID=6390] and control cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.286E-3 4.708E-2
3.685E-1
1.000E0
 2 114
38 M18685 Genes up-regulated in macrophage by live P.gingivalis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.324E-3 4.708E-2
3.685E-1
1.000E0
 3 484
39 16024625-SuppTable2a Human Colon Craene05 185genes GeneSigDB 1.567E-3 4.708E-2
3.685E-1
1.000E0
 2 126
40 18006812-TableS2 Human Lymphoma Piccaluga07 214genes GeneSigDB 1.718E-3 4.708E-2
3.685E-1
1.000E0
 2 132
41 M8917 Genes up-regulated in act CD8 T cells: over-expressing MIR17HG [GeneID=407975] versus activated control. MSigDB C7: Immunologic Signatures (v6.0) 1.744E-3 4.708E-2
3.685E-1
1.000E0
 2 133
42 M4781 Down-regulated genes in angioimmunoblastic lymphoma (AILT) compared to normal T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.770E-3 4.708E-2
3.685E-1
1.000E0
 2 134
43 M2435 Genes up-regulated in mucinous ovarian carcinoma tumors of grades 1 and 2 compared to the normal ovarian survace epithelium tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.849E-3 4.708E-2
3.685E-1
1.000E0
 2 137
44 18338247-SuppTable1 Human Breast Harvell08 183genes GeneSigDB 1.929E-3 4.708E-2
3.685E-1
1.000E0
 2 140
45 M1317 Genes up-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of ELK3 [GeneID=2004] and HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.984E-3 4.708E-2
3.685E-1
1.000E0
 2 142
46 M6765 Genes up-regulated in cells from Flt3L Melanom injected mice: splenic DEC205+ dendritic cells versus CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.011E-3 4.708E-2
3.685E-1
1.000E0
 2 143
47 M2781 Genes down-regulated in DAOY cells (medulloblastoma) upon knockdown of BMI1 [Gene ID=648] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 2.039E-3 4.708E-2
3.685E-1
1.000E0
 2 144
48 M19152 Genes down-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.067E-3 4.708E-2
3.685E-1
1.000E0
 2 145
49 M2696 Genes up-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of RELA [Gene ID=5970] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 2.181E-3 4.708E-2
3.685E-1
1.000E0
 2 149
50 M18058 Genes up-regulated in primary cultures of ovarian surface epithlium cells exposed to progesterone [PubChem=5994] for 5 days. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.268E-3 4.708E-2
3.685E-1
1.000E0
 2 152
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 1641 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e11.5 M GonMes Sma k3 500 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.542E-6 5.813E-3 4.639E-2 5.813E-3 3 62
2 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma 500 dev gonad e12.5 F VasAssocMesStromOvary Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.879E-5 1.535E-2
1.225E-1
 4.725E-2 4 386
3 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.156E-5 1.535E-2
1.225E-1
6.821E-2
 4 424
4 gudmap dev gonad e11.5 M GonMes Sma 500 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.512E-5 1.535E-2
1.225E-1
7.403E-2
 4 433
5 gudmap dev gonad e11.5 F GonMes Sma 500 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.676E-5 1.535E-2
1.225E-1
7.674E-2
 4 437
6 gudmap dev gonad e11.5 M GonMes Sma 200 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 8.107E-5 1.635E-2
1.305E-1
1.330E-1
 3 176
7 gudmap dev gonad e11.5 F GonMes Sma 200 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.102E-5 1.635E-2
1.305E-1
1.494E-1
 3 183
8 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Extraglomerular mesangium (EM)/mid-fetal/EM d Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Extraglomerular mesangium (EM)/mid-fetal/EM d Fetal, Development 9.551E-5 1.635E-2
1.305E-1
1.567E-1
 3 186
9 gudmap dev gonad e11.5 M GonMes Sma k4 200 dev gonad e11.5 M GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.965E-5 1.635E-2
1.305E-1
1.635E-1
 2 30
10 gudmap dev gonad e11.5 F GonMes Sma k4 200 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.965E-5 1.635E-2
1.305E-1
1.635E-1
 2 30
11 Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-G Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-G Lungmap CCHMC 1.570E-4 2.028E-2
1.619E-1
2.576E-1
 3 220
12 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hSert Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hSert Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 1.607E-4 2.028E-2
1.619E-1
2.637E-1
 2 38
13 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hSert Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hSert Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.607E-4 2.028E-2
1.619E-1
2.637E-1
 2 38
14 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 500 k5 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.791E-4 3.028E-2
2.417E-1
4.580E-1
 2 50
15 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-A Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-A Lungmap CCHMC 2.932E-4 3.028E-2
2.417E-1
4.811E-1
 3 272
16 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 1000 k3 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.093E-4 3.028E-2
2.417E-1
5.075E-1
 3 277
17 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.137E-4 3.028E-2
2.417E-1
5.148E-1
 2 53
18 gudmap developingLowerUrinaryTract P1 bladder B 200 k4 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.889E-4 3.545E-2
2.829E-1
6.381E-1
 2 59
19 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.676E-4 3.789E-2
3.024E-1
7.673E-1
 3 319
20 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes 4.806E-4 3.789E-2
3.024E-1
7.886E-1
 3 322
21 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 1000 k5 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.849E-4 3.789E-2
3.024E-1
7.958E-1
 3 323
22 gudmap dev gonad e11.5 F GonMes Sma k3 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 5.629E-4 3.905E-2
3.117E-1
9.237E-1
 2 71
23 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ MDP-2 Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ MDP-2 Top 200 Genes 5.778E-4 3.905E-2
3.117E-1
9.482E-1
 3 343
24 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hNbGaba Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hNbGaba Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 5.788E-4 3.905E-2
3.117E-1
9.499E-1
 2 72
25 ratio EB-blastocyst vs EB-fibro 500 K1 ratio EmbryoidBody-blastocyst vs EmbryoidBody-fibro top-relative-expression-ranked 500 k-means-cluster#1 PCBC 5.950E-4 3.905E-2
3.117E-1
9.763E-1
 2 73
26 Lungmap Mouse Lung E16.5 Matrix fibroblast Subtype Mature fibroblast 1 Lungmap Mouse Lung E16.5 Matrix fibroblast Subtype Mature fibroblast 1 Lungmap CCHMC 6.869E-4 4.255E-2
3.396E-1
1.000E0
 3 364
27 10X Human 8K PBMC CD8 T cells (CCL5, NKG7, GZMK) Subtype CD8 T cells (CCL5, NKG7, GZMK)-CD8 T cells subclass-F (LYZ, S100A8, S100A9) Top 200 Genes 10X Human 8K PBMC CD8 T cells (CCL5, NKG7, GZMK) Subtype CD8 T cells (CCL5, NKG7, GZMK)-CD8 T cells subclass-F (LYZ, S100A8, S100A9) Top 200 Genes 7.204E-4 4.255E-2
3.396E-1
1.000E0
 3 370
28 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-FCN1, LYZ, CTSS Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-FCN1, LYZ, CTSS Top 200 Genes 7.260E-4 4.255E-2
3.396E-1
1.000E0
 3 371
29 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 7.683E-4 4.304E-2
3.435E-1
1.000E0
 2 83
30 PCBC ratio EB from-OSK-L-l-p53KD vs EB from-ESC cfr-2X-p05 Embryoid Body Cells-reprogram OSK-L-l-p53KD vs Embryoid Body Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 7.868E-4 4.304E-2
3.435E-1
1.000E0
 2 84
31 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.582E-4 4.543E-2
3.625E-1
1.000E0
 3 393
32 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.163E-4 4.688E-2
3.741E-1
1.000E0
 3 402
33 gudmap dev gonad e11.5 F GonMes Sma 100 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 9.428E-4 4.688E-2
3.741E-1
1.000E0
 2 92
34 gudmap dev gonad e11.5 F GonMes Sma k1 1000 dev gonad e11.5 F GonMes Sma k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.026E-3 4.911E-2
3.919E-1
1.000E0
 2 96
35 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 500 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.047E-3 4.911E-2
3.919E-1
1.000E0
 3 421
36 gudmap dev gonad e11.5 F PrimGermCell Oct k1 500 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.135E-3 4.996E-2
3.987E-1
1.000E0
 2 101
37 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 1000 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.135E-3 4.996E-2
3.987E-1
1.000E0
 2 101
38 Arv SC-LF 1000 K5 AravindRamakr StemCell-LF top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.157E-3 4.996E-2
3.987E-1
1.000E0
 2 102
Show 33 more annotations

15: Computational [Display Chart] 9 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 11 input genes in category / 425 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-375:TargetScan hsa-miR-375 TargetScan 2.667E-8 1.133E-5 7.515E-5 1.133E-5 4 219
2 hsa-miR-141-3p:Functional MTI Functional MTI miRTarbase 1.291E-6 2.744E-4 1.820E-3 5.489E-4 3 145
3 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 1.854E-5 2.025E-3 1.343E-2 7.880E-3 3 353
4 hsa-miR-873-5p.2:TargetScan hsa-miR-873-5p.2 TargetScan 2.032E-5 2.025E-3 1.343E-2 8.634E-3 3 364
5 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 2.382E-5 2.025E-3 1.343E-2 1.012E-2 3 384
6 hsa-miR-555:mirSVR highEffct hsa-miR-555:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.842E-5 2.224E-3 1.474E-2 1.633E-2 3 451
7 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 4.709E-5 2.224E-3 1.474E-2 2.001E-2 3 483
8 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 4.709E-5 2.224E-3 1.474E-2 2.001E-2 3 483
9 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 4.709E-5 2.224E-3 1.474E-2 2.001E-2 3 483
10 hsa-miR-135a-5p:Functional MTI Functional MTI miRTarbase 9.143E-5 3.886E-3 2.576E-2 3.886E-2 2 94
11 hsa-miR-152-3p:Functional MTI Functional MTI miRTarbase 2.581E-4 9.552E-3
6.334E-2
1.097E-1
 2 158
12 hsa-miR-647:PITA hsa-miR-647:PITA TOP PITA 3.163E-4 9.552E-3
6.334E-2
1.344E-1
 2 175
13 hsa-miR-556-3p:PITA hsa-miR-556-3p:PITA TOP PITA 3.726E-4 9.552E-3
6.334E-2
1.584E-1
 2 190
14 hsa-miR-1183:PITA hsa-miR-1183:PITA TOP PITA 4.044E-4 9.552E-3
6.334E-2
1.719E-1
 2 198
15 hsa-miR-376a-3p:TargetScan hsa-miR-376a-3p TargetScan 4.209E-4 9.552E-3
6.334E-2
1.789E-1
 2 202
16 hsa-miR-376b-3p:TargetScan hsa-miR-376b-3p TargetScan 4.209E-4 9.552E-3
6.334E-2
1.789E-1
 2 202
17 ATATGCA,MIR-448:MSigDB ATATGCA,MIR-448:MSigDB MSigDB 4.250E-4 9.552E-3
6.334E-2
1.806E-1
 2 203
18 hsa-miR-376a:PITA hsa-miR-376a:PITA TOP PITA 4.334E-4 9.552E-3
6.334E-2
1.842E-1
 2 205
19 hsa-miR-376b:PITA hsa-miR-376b:PITA TOP PITA 4.334E-4 9.552E-3
6.334E-2
1.842E-1
 2 205
20 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 4.633E-4 9.552E-3
6.334E-2
1.969E-1
 2 212
21 hsa-miR-573:PITA hsa-miR-573:PITA TOP PITA 4.720E-4 9.552E-3
6.334E-2
2.006E-1
 2 214
22 hsa-miR-145-5p:Functional MTI Functional MTI miRTarbase 5.829E-4 1.025E-2
6.794E-2
2.477E-1
 2 238
23 hsa-miR-1179:PITA hsa-miR-1179:PITA TOP PITA 6.581E-4 1.025E-2
6.794E-2
2.797E-1
 2 253
24 hsa-let-7e*:mirSVR lowEffct hsa-let-7e*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.736E-4 1.025E-2
6.794E-2
2.863E-1
 2 256
25 CACTGCC,MIR-34A:MSigDB CACTGCC,MIR-34A:MSigDB MSigDB 7.322E-4 1.025E-2
6.794E-2
3.112E-1
 2 267
26 CACTGCC,MIR-449:MSigDB CACTGCC,MIR-449:MSigDB MSigDB 7.322E-4 1.025E-2
6.794E-2
3.112E-1
 2 267
27 CACTGCC,MIR-34C:MSigDB CACTGCC,MIR-34C:MSigDB MSigDB 7.322E-4 1.025E-2
6.794E-2
3.112E-1
 2 267
28 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 8.217E-4 1.025E-2
6.794E-2
3.492E-1
 2 283
29 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 8.274E-4 1.025E-2
6.794E-2
3.517E-1
 2 284
30 TGCACTG,MIR-152:MSigDB TGCACTG,MIR-152:MSigDB MSigDB 8.565E-4 1.025E-2
6.794E-2
3.640E-1
 2 289
31 TGCACTG,MIR-148B:MSigDB TGCACTG,MIR-148B:MSigDB MSigDB 8.565E-4 1.025E-2
6.794E-2
3.640E-1
 2 289
32 TGCACTG,MIR-148A:MSigDB TGCACTG,MIR-148A:MSigDB MSigDB 8.565E-4 1.025E-2
6.794E-2
3.640E-1
 2 289
33 hsa-miR-409-3p:PITA hsa-miR-409-3p:PITA TOP PITA 8.861E-4 1.025E-2
6.794E-2
3.766E-1
 2 294
34 hsa-miR-449a:PITA hsa-miR-449a:PITA TOP PITA 8.921E-4 1.025E-2
6.794E-2
3.791E-1
 2 295
35 hsa-miR-34c-5p:PITA hsa-miR-34c-5p:PITA TOP PITA 8.921E-4 1.025E-2
6.794E-2
3.791E-1
 2 295
36 hsa-miR-34a:PITA hsa-miR-34a:PITA TOP PITA 8.921E-4 1.025E-2
6.794E-2
3.791E-1
 2 295
37 hsa-miR-449b:PITA hsa-miR-449b:PITA TOP PITA 8.921E-4 1.025E-2
6.794E-2
3.791E-1
 2 295
38 hsa-miR-342-3p:Functional MTI Functional MTI miRTarbase 9.467E-4 1.059E-2
7.021E-2
4.024E-1
 2 304
39 CACTGTG,MIR-128A:MSigDB CACTGTG,MIR-128A:MSigDB MSigDB 1.016E-3 1.079E-2
7.155E-2
4.317E-1
 2 315
40 CACTGTG,MIR-128B:MSigDB CACTGTG,MIR-128B:MSigDB MSigDB 1.016E-3 1.079E-2
7.155E-2
4.317E-1
 2 315
41 hsa-miR-143-3p:TargetScan hsa-miR-143-3p TargetScan 1.216E-3 1.236E-2
8.196E-2
5.166E-1
 2 345
42 hsa-miR-1537:mirSVR highEffct hsa-miR-1537:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.223E-3 1.236E-2
8.196E-2
5.196E-1
 2 346
43 hsa-miR-9-5p:Functional MTI Functional MTI miRTarbase 1.251E-3 1.236E-2
8.196E-2
5.315E-1
 2 350
44 hsa-miR-323a-3p:TargetScan hsa-miR-323a-3p TargetScan 1.337E-3 1.291E-2
8.561E-2
5.681E-1
 2 362
45 hsa-miR-431*:mirSVR lowEffct hsa-miR-431*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.418E-3 1.339E-2
8.880E-2
6.026E-1
 2 373
46 hsa-let-7d*:mirSVR lowEffct hsa-let-7d*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.595E-3 1.457E-2
9.661E-2
6.781E-1
 2 396
47 hsa-miR-130a-3p:Functional MTI Functional MTI miRTarbase 1.611E-3 1.457E-2
9.661E-2
6.848E-1
 2 398
48 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 1.851E-3 1.639E-2
1.086E-1
7.865E-1
 2 427
49 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.945E-3 1.684E-2
1.117E-1
8.268E-1
 2 438
50 hsa-miR-653-5p:TargetScan hsa-miR-653-5p TargetScan 1.998E-3 1.684E-2
1.117E-1
8.492E-1
 2 444
Show 45 more annotations

17: Drug [Display Chart] 11 input genes in category / 3224 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000006326 vinylene Stitch 5.975E-8 1.926E-4 1.667E-3 1.926E-4 5 245
2 ctd:C553817 7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one CTD 1.605E-5 1.336E-2
1.157E-1
5.174E-2
 3 107
3 3808 UP Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 4.675E-5 1.336E-2
1.157E-1
1.507E-1
 3 153
4 5743 UP Cycloheximide [66-81-9]; Up 200; 14.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.145E-5 1.336E-2
1.157E-1
1.659E-1
 3 158
5 4325 UP Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.242E-5 1.336E-2
1.157E-1
1.690E-1
 3 159
6 5777 UP Spiperone [749-02-0]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.542E-5 1.336E-2
1.157E-1
1.787E-1
 3 162
7 1498 UP Niclosamide [50-65-7]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.645E-5 1.336E-2
1.157E-1
1.820E-1
 3 163
8 2423 UP Digoxin [20830-75-5]; Up 200; 5.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 6.397E-5 1.336E-2
1.157E-1
2.062E-1
 3 170
9 ctd:D010938 Plant Oils CTD 6.422E-5 1.336E-2
1.157E-1
2.071E-1
 4 496
10 4617 UP Thonzonium bromide [553-08-2]; Up 200; 6.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.738E-5 1.336E-2
1.157E-1
2.172E-1
 3 173
11 1230 UP thioridazine hydrochloride; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.333E-5 1.336E-2
1.157E-1
2.364E-1
 3 178
12 1937 UP Azacyclonol [115-46-8]; Up 200; 15uM; PC3; HG-U133A Broad Institute CMAP Up 7.581E-5 1.336E-2
1.157E-1
2.444E-1
 3 180
13 2671 DN retinoic acid; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Down 8.490E-5 1.336E-2
1.157E-1
2.737E-1
 3 187
14 1005 DN 17-AAG; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 8.762E-5 1.336E-2
1.157E-1
2.825E-1
 3 189
15 7088 UP pioglitazone HCl; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.040E-5 1.336E-2
1.157E-1
2.914E-1
 3 191
16 991 DN retinoic acid; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 9.040E-5 1.336E-2
1.157E-1
2.914E-1
 3 191
17 3183 UP Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.323E-5 1.336E-2
1.157E-1
3.006E-1
 3 193
18 5297 UP Tacrine hydrochloride hydrate [1684-40-8]; Up 200; 15.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.613E-5 1.336E-2
1.157E-1
3.099E-1
 3 195
19 999 DN radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 9.613E-5 1.336E-2
1.157E-1
3.099E-1
 3 195
20 5758 UP Phenazopyridine hydrochloride [136-40-3]; Up 200; 16uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.759E-5 1.336E-2
1.157E-1
3.146E-1
 3 196
21 7076 UP PHA-00816795 [212631-79-3]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.006E-4 1.336E-2
1.157E-1
3.243E-1
 3 198
22 3027 UP Dichlorphenamide [120-97-8]; Up 200; 13.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.006E-4 1.336E-2
1.157E-1
3.243E-1
 3 198
23 2993 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.021E-4 1.336E-2
1.157E-1
3.291E-1
 3 199
24 5928 UP PF-00875133-00 [351322-64-0]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.021E-4 1.336E-2
1.157E-1
3.291E-1
 3 199
25 4170 UP Myricetin [529-44-2]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.036E-4 1.336E-2
1.157E-1
3.341E-1
 3 200
26 CID000004683 AC1L1IPV Stitch 1.884E-4 2.336E-2
2.022E-1
6.073E-1
 2 43
27 ctd:C570897 NSC668394 CTD 2.352E-4 2.808E-2
2.431E-1
7.582E-1
 3 264
28 ctd:D012293 Rifampin CTD 5.785E-4 3.557E-2
3.079E-1
1.000E0
 3 359
29 CID000444764 2-(oxalylamino)benzoic acid Stitch 8.070E-4 3.557E-2
3.079E-1
1.000E0
 2 89
30 ctd:C440975 silybin CTD 8.996E-4 3.557E-2
3.079E-1
1.000E0
 2 94
31 CID000069403 propyl isothiocyanate Stitch 9.630E-4 3.557E-2
3.079E-1
1.000E0
 1 2
32 CID006332158 AC1O3MDH Stitch 1.058E-3 3.557E-2
3.079E-1
1.000E0
 2 102
33 CID000449471 AC1L9N61 Stitch 1.058E-3 3.557E-2
3.079E-1
1.000E0
 2 102
34 CID000007104 B on A Stitch 1.217E-3 3.557E-2
3.079E-1
1.000E0
 3 464
35 CID000012388 tridecane Stitch 1.436E-3 3.557E-2
3.079E-1
1.000E0
 2 119
36 CID000212754 A 55 Stitch 1.444E-3 3.557E-2
3.079E-1
1.000E0
 1 3
37 CID009823454 2 VES Stitch 1.444E-3 3.557E-2
3.079E-1
1.000E0
 1 3
38 CID000174626 lactosucrose Stitch 1.444E-3 3.557E-2
3.079E-1
1.000E0
 1 3
39 CID005321393 sophoradin Stitch 1.444E-3 3.557E-2
3.079E-1
1.000E0
 1 3
40 ctd:D002793 Cholic Acids CTD 1.633E-3 3.557E-2
3.079E-1
1.000E0
 2 127
41 CID004369452 T2 D Stitch 1.633E-3 3.557E-2
3.079E-1
1.000E0
 2 127
42 ctd:D011899 Ranitidine CTD 1.710E-3 3.557E-2
3.079E-1
1.000E0
 2 130
43 CID000004961 AC1L1JB6 Stitch 1.736E-3 3.557E-2
3.079E-1
1.000E0
 2 131
44 ctd:C010063 carbonyl sulfide CTD 1.815E-3 3.557E-2
3.079E-1
1.000E0
 2 134
45 ctd:C083763 8-bromoguanosino-3',5'-cyclic monophosphorothioate CTD 1.925E-3 3.557E-2
3.079E-1
1.000E0
 1 4
46 CID000017804 Trimm Stitch 1.925E-3 3.557E-2
3.079E-1
1.000E0
 1 4
47 CID000012227 N'-hydroxyformamidine Stitch 1.925E-3 3.557E-2
3.079E-1
1.000E0
 1 4
48 ctd:C541923 sandostatinLAR CTD 2.178E-3 3.557E-2
3.079E-1
1.000E0
 2 147
49 CID000003547 fasudil Stitch 2.296E-3 3.557E-2
3.079E-1
1.000E0
 2 151
50 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.387E-3 3.557E-2
3.079E-1
1.000E0
 2 154
Show 45 more annotations

18: Disease [Display Chart] 11 input genes in category / 241 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0078911 AIDS-Associated Nephropathy DisGeNET BeFree 1.568E-4 2.337E-2
1.417E-1
 3.780E-2 2 28
2 C0340629 Aortic aneurysm without mention of rupture NOS DisGeNET BeFree 2.187E-4 2.337E-2
1.417E-1
5.270E-2
 2 33
3 cv:C1864839 Maturity-onset diabetes of the young, type 7 Clinical Variations 6.788E-4 2.337E-2
1.417E-1
1.636E-1
 1 1
4 C3809513 AORTIC ANEURYSM, FAMILIAL THORACIC 8 DisGeNET Curated 6.788E-4 2.337E-2
1.417E-1
1.636E-1
 1 1
5 cv:CN180164 Aortic aneurysm, familial thoracic 8 Clinical Variations 6.788E-4 2.337E-2
1.417E-1
1.636E-1
 1 1
6 C1864839 MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 7 (disorder) DisGeNET Curated 6.788E-4 2.337E-2
1.417E-1
1.636E-1
 1 1
7 OMIN:610508 MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 7; MODY7 OMIM 6.788E-4 2.337E-2
1.417E-1
1.636E-1
 1 1
8 C0003486 Aortic Aneurysm DisGeNET Curated 1.102E-3 3.319E-2
2.013E-1
2.655E-1
 2 74
9 C0206713 Papilloma, Intraductal DisGeNET BeFree 1.357E-3 3.634E-2
2.204E-1
3.271E-1
 1 2
10 C0015695 Fatty Liver DisGeNET Curated 1.835E-3 4.086E-2
2.478E-1
4.422E-1
 3 380
11 C1266010 Papillary transitional cell neoplasm of low malignant potential DisGeNET BeFree 2.035E-3 4.086E-2
2.478E-1
4.905E-1
 1 3
12 C1384406 Secretory meningioma DisGeNET BeFree 2.035E-3 4.086E-2
2.478E-1
4.905E-1
 1 3
13 C1519689 Tumor Promotion DisGeNET BeFree 2.243E-3 4.086E-2
2.478E-1
5.406E-1
 2 106
14 20081125:Thomas Prostate cancer GWAS 2.713E-3 4.086E-2
2.478E-1
6.538E-1
 1 4
15 C0684324 Deficiency of phosphoglycerate kinase DisGeNET Curated 2.713E-3 4.086E-2
2.478E-1
6.538E-1
 1 4
16 C1970848 Phosphoglycerate Kinase 1 Deficiency DisGeNET Curated 2.713E-3 4.086E-2
2.478E-1
6.538E-1
 1 4
17 C2711227 Steatohepatitis DisGeNET Curated 3.717E-3 4.804E-2
2.913E-1
8.958E-1
 3 487
18 C0947751 Vascular inflammations DisGeNET BeFree 4.037E-3 4.804E-2
2.913E-1
9.729E-1
 2 143
19 C1266157 Intratubular malignant germ cells DisGeNET BeFree 4.067E-3 4.804E-2
2.913E-1
9.800E-1
 1 6
20 20081125:Hafler Multiple sclerosis GWAS 4.067E-3 4.804E-2
2.913E-1
9.800E-1
 1 6
21 C0268398 Familial lichen amyloidosis DisGeNET Curated 4.260E-3 4.804E-2
2.913E-1
1.000E0
 2 147
22 C0241868 acute aortic dissection DisGeNET BeFree 4.743E-3 4.804E-2
2.913E-1
1.000E0
 1 7
23 C2936380 Neointima DisGeNET Curated 4.743E-3 4.804E-2
2.913E-1
1.000E0
 1 7
24 C0021841 Intestinal Neoplasms DisGeNET Curated 4.784E-3 4.804E-2
2.913E-1
1.000E0
 2 156
25 C0233532 Maladaptive behavior associated with physical illness DisGeNET BeFree 5.419E-3 4.853E-2
2.943E-1
1.000E0
 1 8
26 cv:C0038356 Neoplasm of stomach Clinical Variations 5.419E-3 4.853E-2
2.943E-1
1.000E0
 1 8
27 C0240225 Liver mass DisGeNET BeFree 6.094E-3 4.853E-2
2.943E-1
1.000E0
 1 9
28 C0023897 Liver Diseases, Parasitic DisGeNET Curated 6.094E-3 4.853E-2
2.943E-1
1.000E0
 1 9
29 C0032463 Polycythemia Vera DisGeNET Curated 7.524E-3 4.853E-2
2.943E-1
1.000E0
 2 197
30 C0030354 Papilloma DisGeNET Curated 7.598E-3 4.853E-2
2.943E-1
1.000E0
 2 198
31 OMIN:137215 GASTRIC CANCER OMIM 8.118E-3 4.853E-2
2.943E-1
1.000E0
 1 12
32 C0854148 Cells in urine DisGeNET BeFree 8.118E-3 4.853E-2
2.943E-1
1.000E0
 1 12
33 cv:C0376358 Malignant tumor of prostate Clinical Variations 8.118E-3 4.853E-2
2.943E-1
1.000E0
 1 12
34 C0699889 Malignant Female Reproductive System Neoplasm DisGeNET BeFree 8.118E-3 4.853E-2
2.943E-1
1.000E0
 1 12
35 C1836635 Loeys-Dietz Aortic Aneurysm Syndrome DisGeNET Curated 8.792E-3 4.853E-2
2.943E-1
1.000E0
 1 13
36 C4022878 Descending aortic dissection DisGeNET Curated 8.792E-3 4.853E-2
2.943E-1
1.000E0
 1 13
37 C1836653 Ascending aortic dissection DisGeNET Curated 8.792E-3 4.853E-2
2.943E-1
1.000E0
 1 13
38 C0392775 Cystic medial necrosis of aorta DisGeNET Curated 8.792E-3 4.853E-2
2.943E-1
1.000E0
 1 13
39 C2674574 Aortic aneurysm, familial thoracic 3 DisGeNET Curated 8.792E-3 4.853E-2
2.943E-1
1.000E0
 1 13
40 C1709661 Primary Focal Segmental Glomerulosclerosis DisGeNET BeFree 8.792E-3 4.853E-2
2.943E-1
1.000E0
 1 13
41 C0085110 Severe Combined Immunodeficiency DisGeNET Curated 8.906E-3 4.853E-2
2.943E-1
1.000E0
 2 215
42 C0795841 Jacobsen Distal 11q Deletion Syndrome DisGeNET Curated 9.465E-3 4.853E-2
2.943E-1
1.000E0
 1 14
43 C2987516 Cervix Intraepithelial Neoplasia Grade 3 AJCC v7 DisGeNET BeFree 9.465E-3 4.853E-2
2.943E-1
1.000E0
 1 14
44 C4025845 Abnormality of the iris DisGeNET Curated 9.465E-3 4.853E-2
2.943E-1
1.000E0
 1 14
45 C0023522 Leukodystrophy, Metachromatic DisGeNET Curated 9.465E-3 4.853E-2
2.943E-1
1.000E0
 1 14
46 C0020256 Congenital Hydrocephalus DisGeNET BeFree 9.465E-3 4.853E-2
2.943E-1
1.000E0
 1 14
47 C0013405 Dyspnea, Paroxysmal DisGeNET Curated 9.465E-3 4.853E-2
2.943E-1
1.000E0
 1 14
Show 42 more annotations