Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc133_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 81 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0015111 iodide transmembrane transporter activity 7.752E-7 3.139E-5 1.563E-4 6.279E-5 2 3
2 GO:0004939 beta-adrenergic receptor activity 7.752E-7 3.139E-5 1.563E-4 6.279E-5 2 3
3 GO:0051380 norepinephrine binding 1.550E-6 4.185E-5 2.083E-4 1.255E-4 2 4
4 GO:0051379 epinephrine binding 3.872E-6 7.842E-5 3.904E-4 3.137E-4 2 6
5 GO:0016500 protein-hormone receptor activity 3.089E-5 3.575E-4 1.779E-3 2.502E-3 2 16
6 GO:0004935 adrenergic receptor activity 3.089E-5 3.575E-4 1.779E-3 2.502E-3 2 16
7 GO:1901338 catecholamine binding 3.089E-5 3.575E-4 1.779E-3 2.502E-3 2 16
8 GO:0031690 adrenergic receptor binding 4.886E-5 4.947E-4 2.462E-3 3.957E-3 2 20
9 GO:0008227 G protein-coupled amine receptor activity 3.250E-4 2.713E-3 1.350E-2 2.632E-2 2 51
10 GO:0008507 sodium:iodide symporter activity 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
11 GO:0004940 beta1-adrenergic receptor activity 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
12 GO:0015373 anion:sodium symporter activity 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
13 GO:0038106 choriogonadotropin hormone binding 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
14 GO:0004964 luteinizing hormone receptor activity 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
15 GO:0035472 choriogonadotropin hormone receptor activity 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
16 GO:0015052 beta3-adrenergic receptor activity 5.359E-4 2.713E-3 1.350E-2 4.341E-2 1 1
17 GO:0004996 thyroid-stimulating hormone receptor activity 1.071E-3 4.822E-3 2.400E-2
8.679E-2
 1 2
18 GO:0031699 beta-3 adrenergic receptor binding 1.071E-3 4.822E-3 2.400E-2
8.679E-2
 1 2
19 GO:0008528 G protein-coupled peptide receptor activity 2.153E-3 8.681E-3 4.321E-2
1.744E-1
 2 132
20 GO:0015103 inorganic anion transmembrane transporter activity 2.153E-3 8.681E-3 4.321E-2
1.744E-1
 2 132
21 GO:0001653 peptide receptor activity 2.251E-3 8.681E-3 4.321E-2
1.823E-1
 2 135
22 GO:0031694 alpha-2A adrenergic receptor binding 2.677E-3 9.855E-3 4.906E-2
2.168E-1
 1 5
23 GO:0022853 active ion transmembrane transporter activity 3.745E-3 1.214E-2
6.041E-2
3.034E-1
 2 175
24 GO:0016174 NAD(P)H oxidase activity 3.746E-3 1.214E-2
6.041E-2
3.034E-1
 1 7
25 GO:0034711 inhibin binding 3.746E-3 1.214E-2
6.041E-2
3.034E-1
 1 7
26 GO:0019531 oxalate transmembrane transporter activity 5.880E-3 1.832E-2
9.119E-2
4.763E-1
 1 11
27 GO:0035240 dopamine binding 6.413E-3 1.875E-2
9.336E-2
5.195E-1
 1 12
28 GO:0015291 secondary active transmembrane transporter activity 6.703E-3 1.875E-2
9.336E-2
5.430E-1
 2 236
29 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 6.946E-3 1.875E-2
9.336E-2
5.626E-1
 1 13
30 GO:0008271 secondary active sulfate transmembrane transporter activity 6.946E-3 1.875E-2
9.336E-2
5.626E-1
 1 13
31 GO:0015116 sulfate transmembrane transporter activity 7.479E-3 1.893E-2
9.423E-2
6.058E-1
 1 14
32 GO:0044213 intronic transcription regulatory region DNA binding 7.479E-3 1.893E-2
9.423E-2
6.058E-1
 1 14
33 GO:0001664 G protein-coupled receptor binding 9.069E-3 2.162E-2
1.076E-1
7.346E-1
 2 276
34 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 9.075E-3 2.162E-2
1.076E-1
7.351E-1
 1 17
35 GO:0015106 bicarbonate transmembrane transporter activity 1.014E-2 2.346E-2
1.168E-1
8.211E-1
 1 19
36 GO:0008509 anion transmembrane transporter activity 1.044E-2 2.349E-2
1.169E-1
8.458E-1
 2 297
37 GO:0022804 active transmembrane transporter activity 1.532E-2 3.206E-2
1.596E-1
1.000E0
 2 363
38 GO:1901682 sulfur compound transmembrane transporter activity 1.544E-2 3.206E-2
1.596E-1
1.000E0
 1 29
39 GO:0015301 anion:anion antiporter activity 1.544E-2 3.206E-2
1.596E-1
1.000E0
 1 29
40 GO:0005310 dicarboxylic acid transmembrane transporter activity 1.649E-2 3.340E-2
1.662E-1
1.000E0
 1 31
41 GO:0015026 coreceptor activity 2.229E-2 4.403E-2
2.192E-1
1.000E0
 1 42
42 GO:0017046 peptide hormone binding 2.386E-2 4.495E-2
2.237E-1
1.000E0
 1 45
43 GO:0004601 peroxidase activity 2.386E-2 4.495E-2
2.237E-1
1.000E0
 1 45
44 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2.491E-2 4.571E-2
2.275E-1
1.000E0
 1 47
45 GO:0015296 anion:cation symporter activity 2.543E-2 4.571E-2
2.275E-1
1.000E0
 1 48
46 GO:0015370 solute:sodium symporter activity 2.596E-2 4.571E-2
2.275E-1
1.000E0
 1 49
Show 41 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 545 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0015705 iodide transport 2.228E-9 1.034E-6 7.114E-6 1.214E-6 3 6
2 GO:0007190 activation of adenylate cyclase activity 3.795E-9 1.034E-6 7.114E-6 2.068E-6 4 40
3 GO:0045762 positive regulation of adenylate cyclase activity 8.778E-9 1.595E-6 1.097E-5 4.784E-6 4 49
4 GO:0031281 positive regulation of cyclase activity 2.303E-8 2.511E-6 1.727E-5 1.255E-5 4 62
5 GO:0051349 positive regulation of lyase activity 2.303E-8 2.511E-6 1.727E-5 1.255E-5 4 62
6 GO:0045761 regulation of adenylate cyclase activity 4.737E-8 4.302E-6 2.960E-5 2.581E-5 4 74
7 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 6.836E-8 5.323E-6 3.661E-5 3.726E-5 4 81
8 GO:0006590 thyroid hormone generation 9.060E-8 5.709E-6 3.927E-5 4.937E-5 3 18
9 GO:0031279 regulation of cyclase activity 9.564E-8 5.709E-6 3.927E-5 5.213E-5 4 88
10 GO:0051339 regulation of lyase activity 1.047E-7 5.709E-6 3.927E-5 5.709E-5 4 90
11 GO:1900373 positive regulation of purine nucleotide biosynthetic process 2.354E-7 1.068E-5 7.350E-5 1.283E-4 4 110
12 GO:0030810 positive regulation of nucleotide biosynthetic process 2.354E-7 1.068E-5 7.350E-5 1.283E-4 4 110
13 GO:0042403 thyroid hormone metabolic process 2.549E-7 1.068E-5 7.350E-5 1.389E-4 3 25
14 GO:0030878 thyroid gland development 3.239E-7 1.261E-5 8.674E-5 1.765E-4 3 27
15 GO:0006171 cAMP biosynthetic process 4.196E-7 1.525E-5 1.049E-4 2.287E-4 4 127
16 GO:0045981 positive regulation of nucleotide metabolic process 6.383E-7 2.046E-5 1.408E-4 3.479E-4 4 141
17 GO:1900544 positive regulation of purine nucleotide metabolic process 6.383E-7 2.046E-5 1.408E-4 3.479E-4 4 141
18 GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure 7.783E-7 2.288E-5 1.574E-4 4.242E-4 2 3
19 GO:1900371 regulation of purine nucleotide biosynthetic process 8.178E-7 2.288E-5 1.574E-4 4.457E-4 4 150
20 GO:0030808 regulation of nucleotide biosynthetic process 8.398E-7 2.288E-5 1.574E-4 4.577E-4 4 151
21 GO:0052652 cyclic purine nucleotide metabolic process 9.567E-7 2.326E-5 1.600E-4 5.214E-4 4 156
22 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 9.814E-7 2.326E-5 1.600E-4 5.349E-4 4 157
23 GO:0009190 cyclic nucleotide biosynthetic process 9.814E-7 2.326E-5 1.600E-4 5.349E-4 4 157
24 GO:0046058 cAMP metabolic process 1.085E-6 2.464E-5 1.695E-4 5.915E-4 4 161
25 GO:0035264 multicellular organism growth 1.694E-6 3.693E-5 2.540E-4 9.232E-4 4 180
26 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1.849E-6 3.876E-5 2.666E-4 1.008E-3 4 184
27 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 2.882E-6 5.642E-5 3.881E-4 1.571E-3 3 55
28 GO:0009187 cyclic nucleotide metabolic process 2.899E-6 5.642E-5 3.881E-4 1.580E-3 4 206
29 GO:0042445 hormone metabolic process 3.012E-6 5.661E-5 3.894E-4 1.642E-3 4 208
30 GO:1900542 regulation of purine nucleotide metabolic process 4.262E-6 7.743E-5 5.327E-4 2.323E-3 4 227
31 GO:0006140 regulation of nucleotide metabolic process 4.890E-6 8.597E-5 5.914E-4 2.665E-3 4 235
32 GO:0009152 purine ribonucleotide biosynthetic process 6.758E-6 1.151E-4 7.918E-4 3.683E-3 4 255
33 GO:0042446 hormone biosynthetic process 7.377E-6 1.188E-4 8.170E-4 4.021E-3 3 75
34 GO:0006164 purine nucleotide biosynthetic process 7.410E-6 1.188E-4 8.170E-4 4.038E-3 4 261
35 GO:0009260 ribonucleotide biosynthetic process 8.227E-6 1.281E-4 8.812E-4 4.484E-3 4 268
36 GO:0046390 ribose phosphate biosynthetic process 8.723E-6 1.304E-4 8.968E-4 4.754E-3 4 272
37 GO:0072522 purine-containing compound biosynthetic process 8.850E-6 1.304E-4 8.968E-4 4.824E-3 4 273
38 GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine 9.324E-6 1.337E-4 9.199E-4 5.082E-3 2 9
39 GO:0040014 regulation of multicellular organism growth 1.076E-5 1.504E-4 1.034E-3 5.864E-3 3 85
40 GO:0002024 diet induced thermogenesis 1.424E-5 1.940E-4 1.334E-3 7.759E-3 2 11
41 GO:0009165 nucleotide biosynthetic process 1.676E-5 2.204E-4 1.516E-3 9.136E-3 4 321
42 GO:1990845 adaptive thermogenesis 1.708E-5 2.204E-4 1.516E-3 9.308E-3 2 12
43 GO:1901293 nucleoside phosphate biosynthetic process 1.739E-5 2.204E-4 1.516E-3 9.476E-3 4 324
44 GO:0003073 regulation of systemic arterial blood pressure 1.917E-5 2.374E-4 1.633E-3 1.045E-2 3 103
45 GO:0018958 phenol-containing compound metabolic process 2.089E-5 2.530E-4 1.741E-3 1.139E-2 3 106
46 GO:0043950 positive regulation of cAMP-mediated signaling 2.354E-5 2.788E-4 1.918E-3 1.283E-2 2 14
47 GO:0040015 negative regulation of multicellular organism growth 2.715E-5 3.148E-4 2.165E-3 1.480E-2 2 15
48 GO:0071371 cellular response to gonadotropin stimulus 4.905E-5 5.570E-4 3.831E-3 2.673E-2 2 20
49 GO:0035270 endocrine system development 5.114E-5 5.688E-4 3.913E-3 2.787E-2 3 143
50 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 5.420E-5 5.908E-4 4.064E-3 2.954E-2 2 21
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 10 input genes in category / 14 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043235 receptor complex 6.098E-4 8.537E-3 2.776E-2 8.537E-3 3 339

4: Human Phenotype [Display Chart] 9 input genes in category / 164 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0100786 Hypersomnia 3.435E-10 5.633E-8 3.200E-7 5.633E-8 5 25
2 HP:0000853 Goiter 1.067E-8 8.751E-7 4.971E-6 1.750E-6 6 109
3 HP:0000821 Hypothyroidism 3.319E-8 1.814E-6 1.030E-5 5.443E-6 7 247
4 HP:0002926 Abnormality of thyroid physiology 4.749E-8 1.947E-6 1.106E-5 7.788E-6 7 260
5 HP:0008223 Compensated hypothyroidism 2.695E-7 8.840E-6 5.021E-5 4.420E-5 3 8
6 HP:0000820 Abnormality of the thyroid gland 2.735E-6 5.364E-5 3.047E-4 4.485E-4 7 467
7 HP:0000158 Macroglossia 2.855E-6 5.364E-5 3.047E-4 4.682E-4 5 144
8 HP:0031097 Abnormal thyroid-stimulating hormone level 3.245E-6 5.364E-5 3.047E-4 5.321E-4 3 17
9 HP:0002925 Increased thyroid-stimulating hormone level 3.245E-6 5.364E-5 3.047E-4 5.321E-4 3 17
10 HP:0000239 Large fontanelles 3.271E-6 5.364E-5 3.047E-4 5.364E-4 5 148
11 HP:0011328 Abnormality of fontanelles 6.126E-6 9.133E-5 5.188E-4 1.005E-3 5 168
12 HP:0002360 Sleep disturbance 8.698E-6 1.029E-4 5.843E-4 1.426E-3 6 335
13 HP:0011772 Abnormality of thyroid morphology 8.851E-6 1.029E-4 5.843E-4 1.452E-3 6 336
14 HP:0000280 Coarse facial features 9.339E-6 1.029E-4 5.843E-4 1.532E-3 5 183
15 HP:0012558 Abnormal T3/T4 ratio 9.742E-6 1.029E-4 5.843E-4 1.598E-3 2 3
16 HP:0003712 Skeletal muscle hypertrophy 1.039E-5 1.029E-4 5.843E-4 1.703E-3 5 187
17 HP:0003270 Abdominal distention 1.066E-5 1.029E-4 5.843E-4 1.749E-3 5 188
18 HP:0010514 Hyperpituitarism 1.669E-5 1.520E-4 8.636E-4 2.737E-3 4 93
19 HP:0031508 Abnormal thyroid hormone level 1.946E-5 1.680E-4 9.543E-4 3.192E-3 2 4
20 HP:0000851 Congenital hypothyroidism 5.743E-5 4.710E-4 2.675E-3 9.419E-3 3 43
21 HP:0030809 Abnormal tongue morphology 8.095E-5 6.242E-4 3.545E-3 1.328E-2 5 285
22 HP:0002019 Constipation 8.373E-5 6.242E-4 3.545E-3 1.373E-2 5 287
23 HP:0008191 Thyroid agenesis 9.047E-5 6.451E-4 3.664E-3 1.484E-2 2 8
24 HP:0000958 Dry skin 1.046E-4 7.147E-4 4.060E-3 1.715E-2 4 148
25 HP:0012378 Fatigue 1.351E-4 8.860E-4 5.032E-3 2.215E-2 5 317
26 HP:0000952 Jaundice 1.637E-4 1.033E-3 5.866E-3 2.685E-2 5 330
27 HP:0000235 Abnormality of the fontanelles or cranial sutures 1.888E-4 1.147E-3 6.515E-3 3.097E-2 5 340
28 HP:0000157 Abnormality of the tongue 2.168E-4 1.270E-3 7.214E-3 3.556E-2 5 350
29 HP:0001396 Cholestasis 2.861E-4 1.618E-3 9.190E-3 4.692E-2 5 371
30 HP:0001537 Umbilical hernia 4.450E-4 2.433E-3 1.382E-2
7.298E-2
 4 215
31 HP:0001551 Abnormality of the umbilicus 4.776E-4 2.527E-3 1.435E-2
7.833E-2
 4 219
32 HP:0001462 Abnormality of external features of the abdomen 5.032E-4 2.579E-3 1.465E-2
8.253E-2
 4 222
33 HP:0005990 Thyroid hypoplasia 5.465E-4 2.689E-3 1.527E-2
8.963E-2
 2 19
34 HP:0002890 Thyroid carcinoma 5.575E-4 2.689E-3 1.527E-2
9.143E-2
 3 92
35 HP:0001005 Dermatological manifestations of systemic disorders 6.196E-4 2.903E-3 1.649E-2
1.016E-1
 5 437
36 HP:0000844 Growth hormone and pituitary abnormality 6.672E-4 2.957E-3 1.680E-2
1.094E-1
 4 239
37 HP:0000838 Abnormality of the pituitary gland 6.672E-4 2.957E-3 1.680E-2
1.094E-1
 4 239
38 HP:0008188 Thyroid dysgenesis 7.361E-4 3.177E-3 1.804E-2
1.207E-1
 2 22
39 HP:0100031 Neoplasm of the thyroid gland 7.768E-4 3.266E-3 1.855E-2
1.274E-1
 3 103
40 HP:0004297 Abnormality of the biliary system 9.606E-4 3.938E-3 2.237E-2
1.575E-1
 5 480
41 HP:0011747 Abnormality of the anterior pituitary 1.481E-3 5.924E-3 3.365E-2
2.429E-1
 4 295
42 HP:0012503 Abnormality of the pituitary gland 1.658E-3 6.474E-3 3.677E-2
2.719E-1
 4 304
43 HP:0008251 Congenital goiter 1.912E-3 6.672E-3 3.790E-2
3.136E-1
 1 1
44 HP:0012188 Hyperemesis gravidarum 1.912E-3 6.672E-3 3.790E-2
3.136E-1
 1 1
45 HP:0011790 Activating thyroid-stimulating hormone receptor defect 1.912E-3 6.672E-3 3.790E-2
3.136E-1
 1 1
46 HP:0011789 Thyroid-stimulating hormone receptor defect 1.912E-3 6.672E-3 3.790E-2
3.136E-1
 1 1
47 HP:0012560 Decreased T3/T4 ratio 1.912E-3 6.672E-3 3.790E-2
3.136E-1
 1 1
48 HP:0000864 Abnormality of the hypothalamus-pituitary axis 2.545E-3 8.696E-3 4.940E-2
4.174E-1
 4 341
49 HP:0004299 Hernia of the abdominal wall 3.341E-3 1.118E-2
6.351E-2
5.479E-1
 4 367
50 HP:0001254 Lethargy 3.655E-3 1.182E-2
6.716E-2
5.994E-1
 3 176
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 10 input genes in category / 586 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003971 abnormal thyroid-stimulating hormone level 7.396E-13 4.334E-10 3.013E-9 4.334E-10 6 43
2 MP:0005122 increased circulating thyroid-stimulating hormone level 5.140E-12 1.506E-9 1.047E-8 3.012E-9 5 21
3 MP:0005135 increased thyroid-stimulating hormone level 1.658E-11 3.239E-9 2.252E-8 9.718E-9 5 26
4 MP:0004696 abnormal thyroid follicle morphology 2.476E-11 3.627E-9 2.521E-8 1.451E-8 5 28
5 MP:0005116 abnormal circulating pituitary hormone level 6.922E-11 8.112E-9 5.639E-8 4.056E-8 7 189
6 MP:0000681 abnormal thyroid gland morphology 8.511E-11 8.313E-9 5.778E-8 4.988E-8 6 92
7 MP:0003965 abnormal pituitary hormone level 2.222E-10 1.861E-8 1.293E-7 1.302E-7 7 223
8 MP:0005117 increased circulating pituitary hormone level 3.702E-10 2.712E-8 1.885E-7 2.169E-7 6 117
9 MP:0003351 decreased circulating levels of thyroid hormone 5.863E-10 3.817E-8 2.653E-7 3.435E-7 5 51
10 MP:0003973 increased pituitary hormone level 8.838E-10 5.179E-8 3.600E-7 5.179E-7 6 135
11 MP:0005479 decreased circulating triiodothyronine level 1.688E-9 8.994E-8 6.252E-7 9.893E-7 4 19
12 MP:0005473 decreased triiodothyronine level 3.850E-9 1.880E-7 1.307E-6 2.256E-6 4 23
13 MP:0005468 abnormal thyroid hormone level 6.317E-9 2.848E-7 1.980E-6 3.702E-6 5 81
14 MP:0005476 abnormal circulating triiodothyronine level 1.030E-8 4.310E-7 2.996E-6 6.034E-6 4 29
15 MP:0005472 abnormal triiodothyronine level 1.771E-8 6.918E-7 4.809E-6 1.038E-5 4 33
16 MP:0005478 decreased circulating thyroxine level 7.019E-8 2.571E-6 1.787E-5 4.113E-5 4 46
17 MP:0005471 decreased thyroxine level 1.255E-7 4.328E-6 3.008E-5 7.357E-5 4 53
18 MP:0005475 abnormal circulating thyroxine level 2.710E-7 8.823E-6 6.133E-5 1.588E-4 4 64
19 MP:0005355 enlarged thyroid gland 3.609E-7 1.113E-5 7.737E-5 2.115E-4 3 16
20 MP:0005469 abnormal thyroxine level 4.372E-7 1.281E-5 8.905E-5 2.562E-4 4 72
21 MP:0003503 decreased activity of thyroid 9.893E-7 2.761E-5 1.919E-4 5.797E-4 3 22
22 MP:0002876 abnormal thyroid physiology 3.821E-6 9.735E-5 6.767E-4 2.239E-3 3 34
23 MP:0003149 abnormal tectorial membrane morphology 3.821E-6 9.735E-5 6.767E-4 2.239E-3 3 34
24 MP:0000633 abnormal pituitary gland morphology 6.677E-6 1.630E-4 1.133E-3 3.913E-3 4 142
25 MP:0000631 abnormal neuroendocrine gland morphology 1.363E-5 3.196E-4 2.222E-3 7.990E-3 4 170
26 MP:0009119 increased brown fat cell size 1.758E-5 3.963E-4 2.755E-3 1.030E-2 2 7
27 MP:0011049 impaired adaptive thermogenesis 3.581E-5 7.773E-4 5.403E-3 2.099E-2 3 71
28 MP:0002782 abnormal testes secretion 7.592E-5 1.589E-3 1.104E-2 4.449E-2 2 14
29 MP:0009344 abnormal ovulation cycle 8.302E-5 1.622E-3 1.127E-2 4.865E-2 3 94
30 MP:0001927 abnormal estrous cycle 8.302E-5 1.622E-3 1.127E-2 4.865E-2 3 94
31 MP:0009294 increased interscapular fat pad weight 8.755E-5 1.655E-3 1.150E-2
5.131E-2
 2 15
32 MP:0004163 abnormal adenohypophysis morphology 1.059E-4 1.936E-3 1.346E-2
6.206E-2
 3 102
33 MP:0011019 abnormal adaptive thermogenesis 1.090E-4 1.936E-3 1.346E-2
6.389E-2
 3 103
34 MP:0009135 abnormal brown fat cell size 1.580E-4 2.650E-3 1.842E-2
9.260E-2
 2 20
35 MP:0000830 abnormal diencephalon morphology 1.583E-4 2.650E-3 1.842E-2
9.277E-2
 4 318
36 MP:0002779 abnormal sex gland secretion 1.919E-4 3.124E-3 2.172E-2
1.125E-1
 2 22
37 MP:0001260 increased body weight 2.292E-4 3.535E-3 2.457E-2
1.343E-1
 4 350
38 MP:0012323 increased total tissue mass 2.292E-4 3.535E-3 2.457E-2
1.343E-1
 4 350
39 MP:0004884 abnormal testis physiology 2.909E-4 4.370E-3 3.038E-2
1.704E-1
 2 27
40 MP:0001264 increased body size 3.577E-4 5.240E-3 3.643E-2
2.096E-1
 4 393
41 MP:0002951 small thyroid gland 4.362E-4 6.086E-3 4.231E-2
2.556E-1
 2 33
42 MP:0009009 absent estrous cycle 4.362E-4 6.086E-3 4.231E-2
2.556E-1
 2 33
43 MP:0005185 decreased circulating progesterone level 4.910E-4 6.692E-3 4.652E-2
2.877E-1
 2 35
44 MP:0006320 abnormal interscapular fat pad morphology 5.197E-4 6.921E-3 4.811E-2
3.045E-1
 2 36
45 MP:0005184 abnormal circulating progesterone level 8.493E-4 1.106E-2
7.688E-2
4.977E-1
 2 46
46 MP:0011384 abnormal progesterone level 9.635E-4 1.110E-2
7.713E-2
5.646E-1
 2 49
47 MP:0013327 abnormal male reproductive gland physiology 9.635E-4 1.110E-2
7.713E-2
5.646E-1
 2 49
48 MP:0003501 iodide oxidation defect 9.657E-4 1.110E-2
7.713E-2
5.659E-1
 1 1
49 MP:0013489 abnormal infundibular recess of third ventricle morphology 9.657E-4 1.110E-2
7.713E-2
5.659E-1
 1 1
50 MP:0013490 absent infundibular recess of third ventricle 9.657E-4 1.110E-2
7.713E-2
5.659E-1
 1 1
Show 45 more annotations

6: Domain [Display Chart] 10 input genes in category / 87 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR002131 Gphrmn rcpt fam InterPro 3.842E-6 2.504E-4 1.264E-3 3.343E-4 2 6
2 IPR026906 LRR 5 InterPro 1.151E-5 2.504E-4 1.264E-3 1.002E-3 2 10
3 IPR002233 ADR fam InterPro 1.151E-5 2.504E-4 1.264E-3 1.002E-3 2 10
4 PF13306 LRR 5 Pfam 1.151E-5 2.504E-4 1.264E-3 1.002E-3 2 10
5 IPR002274 TSH rcpt InterPro 5.338E-4 4.644E-3 2.345E-2 4.644E-2 1 1
6 IPR000681 ADRB3 rcpt InterPro 5.338E-4 4.644E-3 2.345E-2 4.644E-2 1 1
7 IPR030285 Pendrin InterPro 5.338E-4 4.644E-3 2.345E-2 4.644E-2 1 1
8 IPR000507 ADRB1 rcpt InterPro 5.338E-4 4.644E-3 2.345E-2 4.644E-2 1 1
9 IPR016324 Thyroglobulin InterPro 5.338E-4 4.644E-3 2.345E-2 4.644E-2 1 1
10 IPR002273 LSH rcpt InterPro 5.338E-4 4.644E-3 2.345E-2 4.644E-2 1 1
11 IPR029595 DUOX1 InterPro 1.067E-3 8.441E-3 4.262E-2
9.285E-2
 1 2
12 SM01381 7TM GPCR Srsx SMART 1.545E-3 1.120E-2
5.655E-2
1.344E-1
 2 112
13 IPR013121 Fe red NAD-bd 6 InterPro 3.731E-3 1.425E-2
7.195E-2
3.246E-1
 1 7
14 IPR018045 S04 transporter CS InterPro 3.731E-3 1.425E-2
7.195E-2
3.246E-1
 1 7
15 PF08022 FAD binding 8 Pfam 3.731E-3 1.425E-2
7.195E-2
3.246E-1
 1 7
16 IPR013112 FAD-bd 8 InterPro 3.731E-3 1.425E-2
7.195E-2
3.246E-1
 1 7
17 PF08030 NAD binding 6 Pfam 3.731E-3 1.425E-2
7.195E-2
3.246E-1
 1 7
18 IPR018212 Na/solute symporter CS InterPro 4.263E-3 1.425E-2
7.195E-2
3.709E-1
 1 8
19 IPR010255 Haem peroxidase InterPro 5.326E-3 1.425E-2
7.195E-2
4.634E-1
 1 10
20 PF03098 An peroxidase Pfam 5.326E-3 1.425E-2
7.195E-2
4.634E-1
 1 10
21 1.10.640.10 - Gene3D 5.326E-3 1.425E-2
7.195E-2
4.634E-1
 1 10
22 PS01130 SLC26A PROSITE 5.326E-3 1.425E-2
7.195E-2
4.634E-1
 1 10
23 PS50292 PEROXIDASE 3 PROSITE 5.326E-3 1.425E-2
7.195E-2
4.634E-1
 1 10
24 IPR019791 Haem peroxidase animal InterPro 5.326E-3 1.425E-2
7.195E-2
4.634E-1
 1 10
25 PS50801 STAS PROSITE 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
26 PF07699 Ephrin rec like Pfam 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
27 IPR001902 SLC26A/SulP fam InterPro 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
28 PF00916 Sulfate transp Pfam 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
29 IPR011547 SLC26A/SulP dom InterPro 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
30 IPR002645 STAS dom InterPro 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
31 3.30.750.24 - Gene3D 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
32 PS00456 NA SOLUT SYMP 1 PROSITE 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
33 PF01740 STAS Pfam 5.857E-3 1.425E-2
7.195E-2
5.096E-1
 1 11
34 IPR013130 Fe3 Rdtase TM dom InterPro 6.388E-3 1.425E-2
7.195E-2
5.558E-1
 1 12
35 PF01794 Ferric reduct Pfam 6.388E-3 1.425E-2
7.195E-2
5.558E-1
 1 12
36 PF00474 SSF Pfam 6.388E-3 1.425E-2
7.195E-2
5.558E-1
 1 12
37 PS00457 NA SOLUT SYMP 2 PROSITE 6.388E-3 1.425E-2
7.195E-2
5.558E-1
 1 12
38 PS50283 NA SOLUT SYMP 3 PROSITE 6.388E-3 1.425E-2
7.195E-2
5.558E-1
 1 12
39 IPR001734 Na/solute symporter InterPro 6.388E-3 1.425E-2
7.195E-2
5.558E-1
 1 12
40 IPR019819 Carboxylesterase B CS InterPro 6.919E-3 1.505E-2
7.598E-2
6.019E-1
 1 13
41 PF00135 COesterase Pfam 7.449E-3 1.507E-2
7.610E-2
6.481E-1
 1 14
42 IPR002018 CarbesteraseB InterPro 7.449E-3 1.507E-2
7.610E-2
6.481E-1
 1 14
43 PS00941 CARBOXYLESTERASE B 2 PROSITE 7.449E-3 1.507E-2
7.610E-2
6.481E-1
 1 14
44 IPR000716 Thyroglobulin 1 InterPro 9.039E-3 1.605E-2
8.103E-2
7.864E-1
 1 17
45 SM00211 TY SMART 9.039E-3 1.605E-2
8.103E-2
7.864E-1
 1 17
46 4.10.800.10 - Gene3D 9.039E-3 1.605E-2
8.103E-2
7.864E-1
 1 17
47 PF00086 Thyroglobulin 1 Pfam 9.039E-3 1.605E-2
8.103E-2
7.864E-1
 1 17
48 PS00484 THYROGLOBULIN 1 1 PROSITE 9.039E-3 1.605E-2
8.103E-2
7.864E-1
 1 17
49 PS51162 THYROGLOBULIN 1 2 PROSITE 9.039E-3 1.605E-2
8.103E-2
7.864E-1
 1 17
50 IPR017927 Fd Rdtase FAD-bd InterPro 1.010E-2 1.689E-2
8.530E-2
8.785E-1
 1 19
Show 45 more annotations

7: Pathway [Display Chart] 9 input genes in category / 56 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 835410 Thyroid hormone synthesis BioSystems: KEGG 8.000E-10 4.480E-8 2.066E-7 4.480E-8 5 74
2 1269575 G alpha (s) signalling events BioSystems: REACTOME 2.185E-6 6.118E-5 2.821E-4 1.224E-4 4 146
3 1222950 Regulation of lipolysis in adipocytes BioSystems: KEGG 6.361E-6 1.187E-4 5.476E-4 3.562E-4 3 54
4 1269555 Adrenoceptors BioSystems: REACTOME 1.668E-5 2.334E-4 1.076E-3 9.341E-4 2 9
5 1270177 Thyroxine biosynthesis BioSystems: REACTOME 2.084E-5 2.334E-4 1.076E-3 1.167E-3 2 10
6 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 2.806E-5 2.619E-4 1.208E-3 1.572E-3 4 278
7 1269559 Hormone ligand-binding receptors BioSystems: REACTOME 3.609E-5 2.887E-4 1.331E-3 2.021E-3 2 13
8 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 4.994E-5 3.496E-4 1.612E-3 2.797E-3 4 322
9 PW:0000227 G protein signaling via Galphas family Pathway Ontology 7.065E-5 3.956E-4 1.824E-3 3.956E-3 2 18
10 1270175 Amine-derived hormones BioSystems: REACTOME 7.065E-5 3.956E-4 1.824E-3 3.956E-3 2 18
11 1269544 GPCR ligand binding BioSystems: REACTOME 1.916E-4 9.756E-4 4.499E-3 1.073E-2 4 455
12 83050 Calcium signaling pathway BioSystems: KEGG 2.419E-4 1.109E-3 5.115E-3 1.355E-2 3 182
13 138034 Arf6 signaling events BioSystems: Pathway Interaction Database 2.575E-4 1.109E-3 5.115E-3 1.442E-2 2 34
14 1269553 Amine ligand-binding receptors BioSystems: REACTOME 4.131E-4 1.652E-3 7.620E-3 2.313E-2 2 43
15 83121 Autoimmune thyroid disease BioSystems: KEGG 6.280E-4 2.345E-3 1.081E-2 3.517E-2 2 53
16 PW:0000467 peptide and protein hormone signaling Pathway Ontology 7.229E-4 2.530E-3 1.167E-2 4.048E-2 1 1
17 1222951 Renin secretion BioSystems: KEGG 9.437E-4 3.109E-3 1.434E-2
5.285E-2
 2 65
18 153376 Salivary secretion BioSystems: KEGG 1.800E-3 5.600E-3 2.583E-2
1.008E-1
 2 90
19 1269908 Transport of inorganic cations/anions and amino acids/oligopeptides BioSystems: REACTOME 2.533E-3 7.465E-3 3.442E-2
1.418E-1
 2 107
20 P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PantherDB 4.911E-3 1.375E-2
6.341E-2
2.750E-1
 2 150
21 SMP00338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin SMPDB 5.770E-3 1.470E-2
6.777E-2
3.231E-1
 1 8
22 983748 cGMP-PKG signaling pathway BioSystems: KEGG 5.774E-3 1.470E-2
6.777E-2
3.233E-1
 2 163
23 1269917 Organic anion transporters BioSystems: REACTOME 7.208E-3 1.682E-2
7.756E-2
4.037E-1
 1 10
24 1269913 Multifunctional anion exchangers BioSystems: REACTOME 7.208E-3 1.682E-2
7.756E-2
4.037E-1
 1 10
25 1017634 cAMP signaling pathway BioSystems: KEGG 8.417E-3 1.802E-2
8.309E-2
4.714E-1
 2 198
26 SMP00306 Pindolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
27 SMP00304 Oxprenolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
28 SMP00301 Esmolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
29 SMP00303 Nadolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
30 SMP00297 Alprenolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
31 SMP00366 Nebivolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
32 SMP00307 Propranolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
33 SMP00299 Betaxolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
34 SMP00300 Bisoprolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
35 SMP00305 Penbutolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
36 SMP00298 Atenolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
37 SMP00296 Acebutolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
38 SMP00302 Metoprolol Pathway SMPDB 1.223E-2 1.802E-2
8.309E-2
6.847E-1
 1 17
39 102279 Endocytosis BioSystems: KEGG 1.420E-2 2.039E-2
9.401E-2
7.950E-1
 2 260
40 SMP00368 Labetalol Pathway SMPDB 1.508E-2 2.060E-2
9.500E-2
8.447E-1
 1 21
41 SMP00367 Carvedilol Pathway SMPDB 1.508E-2 2.060E-2
9.500E-2
8.447E-1
 1 21
42 1269907 SLC-mediated transmembrane transport BioSystems: REACTOME 1.713E-2 2.243E-2
1.034E-1
9.593E-1
 2 287
43 SMP00006 Tyrosine Metabolism SMPDB 1.722E-2 2.243E-2
1.034E-1
9.644E-1
 1 24
44 P04379 Beta3 adrenergic receptor signaling pathway PantherDB 1.864E-2 2.373E-2
1.094E-1
1.000E0
 1 26
45 M2701 Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. MSigDB C2 BIOCARTA (v6.0) 1.936E-2 2.409E-2
1.111E-1
1.000E0
 1 27
46 1270158 Metabolism of amino acids and derivatives BioSystems: REACTOME 2.720E-2 3.311E-2
1.527E-1
1.000E0
 2 367
47 P04377 Beta1 adrenergic receptor signaling pathway PantherDB 3.067E-2 3.585E-2
1.653E-1
1.000E0
 1 43
48 137911 FOXA2 and FOXA3 transcription factor networks BioSystems: Pathway Interaction Database 3.137E-2 3.585E-2
1.653E-1
1.000E0
 1 44
49 137954 Arf6 trafficking events BioSystems: Pathway Interaction Database 3.137E-2 3.585E-2
1.653E-1
1.000E0
 1 44
50 790011 Ovarian steroidogenesis BioSystems: KEGG 3.558E-2 3.985E-2
1.838E-1
1.000E0
 1 50
Show 45 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 3259 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17332529 Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. Pubmed 2.233E-18 7.277E-15 6.307E-14 7.277E-15 5 6
2 12432093 Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Pubmed 1.657E-13 2.701E-10 2.341E-9 5.402E-10 4 8
3 22132122 The microRNA-processing enzyme Dicer is essential for thyroid function. Pubmed 1.171E-12 1.273E-9 1.103E-8 3.818E-9 4 12
4 25127920 The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Pubmed 1.692E-12 1.378E-9 1.195E-8 5.514E-9 4 13
5 24265449 The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production. Pubmed 9.165E-12 5.764E-9 4.995E-8 2.987E-8 4 19
6 16260629 Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells. Pubmed 1.292E-11 5.764E-9 4.995E-8 4.212E-8 3 3
7 28396984 Iodinated TG in Thyroid Follicles Regulate TSH/TSHR Signaling for NIS Expression. Pubmed 1.292E-11 5.764E-9 4.995E-8 4.212E-8 3 3
8 23707896 Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Pubmed 1.415E-11 5.764E-9 4.995E-8 4.611E-8 4 21
9 15231702 Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases. Pubmed 5.169E-11 1.685E-8 1.460E-7 1.685E-7 3 4
10 28322461 Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway. Pubmed 5.169E-11 1.685E-8 1.460E-7 1.685E-7 3 4
11 20578903 Initial characterization of C16orf89, a novel thyroid-specific gene. Pubmed 1.292E-10 3.828E-8 3.318E-7 4.211E-7 3 5
12 17854396 Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake. Pubmed 2.584E-10 6.477E-8 5.614E-7 8.421E-7 3 6
13 16150900 A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Pubmed 2.584E-10 6.477E-8 5.614E-7 8.421E-7 3 6
14 12815622 Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice. Pubmed 1.085E-9 2.525E-7 2.188E-6 3.535E-6 3 9
15 21364918 Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. Pubmed 1.549E-9 3.156E-7 2.735E-6 5.050E-6 3 10
16 21345181 In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. Pubmed 1.549E-9 3.156E-7 2.735E-6 5.050E-6 3 10
17 12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. Pubmed 2.154E-9 4.130E-7 3.579E-6 7.020E-6 4 70
18 19730683 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Pubmed 8.812E-9 1.595E-6 1.383E-5 2.872E-5 4 99
19 23563309 Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. Pubmed 2.964E-8 4.904E-6 4.250E-5 9.659E-5 3 25
20 2293030 Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
21 29587766 ADRB3 polymorphism rs4994 (Trp64Arg) associates significantly with bodyweight elevation and dyslipidaemias in Saudis but not rs1801253 (Arg389Gly) polymorphism in ARDB1. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
22 21989446 Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
23 14633662 Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
24 23174149 Iodide transporters expression in early human invasive trophoblast. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
25 1651314 Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
26 2249482 Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
27 28743746 De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
28 19196800 Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
29 22781452 [Influences of nevirapine on cell proliferation and expression of sodium/iodide symporter in human anaplastic thyroid carcinoma cell line]. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
30 18162522 An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
31 16631628 Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
32 12907760 Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
33 18379122 Thyrotropin receptor and thyroid transcription factor-1 genes variant in Chinese children with congenital hypothyroidism. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
34 17938324 Methylation status of genes in papillary thyroid carcinoma. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
35 29092890 Association between monoallelic TSHR mutations and congenital hypothyroidism: a statistical approach. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
36 22309849 Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
37 24353283 Different expression of TSH receptor and NIS genes in thyroid cancer: role of epigenetics. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
38 24972470 Association of β1 and β3 adrenergic receptors gene polymorphisms with insulin resistance and high lipid profiles related to type 2 diabetes and metabolic syndrome. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
39 22306453 Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
40 11312274 A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
41 22517745 Human fibrocytes coexpress thyroglobulin and thyrotropin receptor. Pubmed 6.170E-8 4.904E-6 4.250E-5 2.011E-4 2 2
42 18240029 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Pubmed 1.495E-7 6.777E-6 5.873E-5 4.872E-4 4 200
43 9697704 A mouse model for hereditary thyroid dysgenesis and cleft palate. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
44 12387862 Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
45 15474034 Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
46 24885710 Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
47 18239290 Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
48 12709678 Relationship of clinical features and laboratory parameters to thyroid echogenicity measured by standardized grey scale ultrasonography in patients with Hashimoto's thyroiditis. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
49 18311486 Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
50 19420258 Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. Pubmed 1.851E-7 6.777E-6 5.873E-5 6.032E-4 2 3
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 269 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GNAS GNAS interactions 1.660E-5 2.403E-3 1.484E-2 4.464E-3 3 105
2 int:LHCGR LHCGR interactions 1.787E-5 2.403E-3 1.484E-2 4.807E-3 2 13
3 int:TSHR TSHR interactions 2.052E-4 1.840E-2
1.136E-1
5.521E-2
 2 43
4 int:CANX CANX interactions 2.784E-4 1.872E-2
1.156E-1
7.488E-2
 3 271
5 int:GIPC1 GIPC1 interactions 6.763E-4 3.638E-2
2.246E-1
1.819E-1
 2 78
6 int:DUOX2 DUOX2 interactions 1.017E-3 3.906E-2
2.412E-1
2.735E-1
 1 2
7 int:GSX2 GSX2 interactions 1.017E-3 3.906E-2
2.412E-1
2.735E-1
 1 2
Show 2 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q13 14q13 2.018E-3 1.297E-2 3.799E-2 2.018E-2 1 7
2 14q31 14q31 2.594E-3 1.297E-2 3.799E-2 2.594E-2 1 9
3 15q15.3 15q15.3 7.477E-3 1.389E-2 4.070E-2
7.477E-2
 1 26
4 7q31 7q31 7.763E-3 1.389E-2 4.070E-2
7.763E-2
 1 27
5 10q25.3 10q25.3 8.336E-3 1.389E-2 4.070E-2
8.336E-2
 1 29
6 8q24 8q24 8.336E-3 1.389E-2 4.070E-2
8.336E-2
 1 29
7 Xq25 Xq25 1.177E-2 1.681E-2 4.924E-2
1.177E-1
 1 41
8 8p12 8p12 1.405E-2 1.756E-2
5.144E-2
1.405E-1
 1 49
9 2p21 2p21 1.860E-2 2.066E-2
6.053E-2
1.860E-1
 1 65
10 19p13.11 19p13.11 2.200E-2 2.200E-2
6.443E-2
2.200E-1
 1 77
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 69 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 9 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 199 Glycoprotein hormone receptors genenames.org 6.524E-7 4.567E-6 1.184E-5 4.567E-6 2 3
2 169 Adrenoceptors genenames.org 7.817E-6 2.736E-5 7.094E-5 5.472E-5 2 9
3 752 Solute carriers genenames.org 1.530E-2 3.570E-2
9.257E-2
1.071E-1
 2 395

13: Coexpression [Display Chart] 10 input genes in category / 528 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15548687-table1 Human StemCell Staege04 38genes GeneSigDB 6.317E-5 3.290E-2
2.253E-1
 3.336E-2 2 28
2 M1449 Genes down-regulated in adipose tissue from obese mouse strains compared to the lean ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.877E-4 3.290E-2
2.253E-1
9.908E-2
 2 48
3 M2135 Cluster 1: genes with similar expression profiles across follicular thyrorid carcinoma (FTC) samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.120E-4 3.290E-2
2.253E-1
1.119E-1
 2 51
4 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 2.493E-4 3.290E-2
2.253E-1
1.316E-1
 3 303
5 20161705-Table2 Mouse EmbryonicStemCell Layden10 73genes GeneSigDB 3.884E-4 4.101E-2
2.808E-1
2.051E-1
 2 69

14: Coexpression Atlas [Display Chart] 10 input genes in category / 444 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 thyroid gland thyroid gland Human Protein Atlas 3.359E-10 1.491E-7 9.953E-7 1.491E-7 6 240
2 BM Top 100 - thyroid gland BM Top 100 - thyroid gland Body Map 4.234E-6 9.399E-4 6.273E-3 1.880E-3 3 73
3 Facebase RNAseq e10.5 Medial Nasal Eminence 500 K2 FacebaseRNAseq e10.5 Medial Nasal Eminence top-relative-expression-ranked 500 k-means-cluster#2 FaceBase_RNAseq 2.196E-4 3.250E-2
2.169E-1
9.750E-2
 2 49

15: Computational [Display Chart] 10 input genes in category / 32 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 10 input genes in category / 212 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-let-7f-5p:Functional MTI Functional MTI miRTarbase 1.921E-5 4.072E-3 2.417E-2 4.072E-3 3 397
2 hsa-miR-1294:PITA hsa-miR-1294:PITA TOP PITA 2.592E-4 1.119E-2
6.642E-2
5.496E-2
 2 175
3 hsa-miR-4469:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.971E-4 1.119E-2
6.642E-2
1.690E-1
 2 308
4 hsa-miR-10b-5p:Functional MTI Functional MTI miRTarbase 8.758E-4 1.119E-2
6.642E-2
1.857E-1
 2 323
5 CTACCTC,LET-7A:MSigDB CTACCTC,LET-7A:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
6 CTACCTC,LET-7C:MSigDB CTACCTC,LET-7C:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
7 CTACCTC,LET-7I:MSigDB CTACCTC,LET-7I:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
8 CTACCTC,LET-7D:MSigDB CTACCTC,LET-7D:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
9 CTACCTC,LET-7E:MSigDB CTACCTC,LET-7E:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
10 CTACCTC,LET-7F:MSigDB CTACCTC,LET-7F:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
11 CTACCTC,MIR-98:MSigDB CTACCTC,MIR-98:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
12 CTACCTC,LET-7G:MSigDB CTACCTC,LET-7G:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
13 CTACCTC,LET-7B:MSigDB CTACCTC,LET-7B:MSigDB MSigDB 1.097E-3 1.119E-2
6.642E-2
2.326E-1
 2 362
14 hsa-miR-98:PITA hsa-miR-98:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
15 hsa-let-7g:PITA hsa-let-7g:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
16 hsa-let-7e:PITA hsa-let-7e:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
17 hsa-let-7b:PITA hsa-let-7b:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
18 hsa-let-7c:PITA hsa-let-7c:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
19 hsa-let-7d:PITA hsa-let-7d:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
20 hsa-let-7i:PITA hsa-let-7i:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
21 hsa-let-7a:PITA hsa-let-7a:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
22 hsa-let-7f:PITA hsa-let-7f:PITA TOP PITA 1.164E-3 1.119E-2
6.642E-2
2.468E-1
 2 373
23 hsa-miR-4257:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.214E-3 1.119E-2
6.642E-2
2.574E-1
 2 381
24 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 1.356E-3 1.198E-2
7.111E-2
2.875E-1
 2 403
25 hsa-miR-3612:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.499E-3 1.239E-2
7.357E-2
3.178E-1
 2 424
26 hsa-miR-650:Functional MTI Functional MTI miRTarbase 1.520E-3 1.239E-2
7.357E-2
3.223E-1
 2 427
27 hsa-miR-2467-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.620E-3 1.272E-2
7.550E-2
3.434E-1
 2 441
28 hsa-miR-10a-5p:Functional MTI Functional MTI miRTarbase 1.783E-3 1.350E-2
8.013E-2
3.779E-1
 2 463
29 hsa-miR-3199:mirSVR highEffct hsa-miR-3199:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.969E-3 1.439E-2
8.545E-2
4.174E-1
 2 487
30 hsa-miR-4715-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.593E-3 2.539E-2
1.507E-1
7.618E-1
 1 26
31 hsa-miR-4661-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.386E-3 3.683E-2
2.186E-1
1.000E0
 1 39
32 hsa-miR-4703-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 4.474E-2
2.656E-1
1.000E0
 1 49
33 hsa-miR-7161-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.038E-3 4.474E-2
2.656E-1
1.000E0
 1 51
34 hsa-miR-1273d:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.175E-3 4.474E-2
2.656E-1
1.000E0
 1 52
35 hsa-miR-758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.000E-3 4.663E-2
2.768E-1
1.000E0
 1 58
36 hsa-miR-647:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.000E-3 4.663E-2
2.768E-1
1.000E0
 1 58
37 hsa-miR-1244:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.138E-3 4.663E-2
2.768E-1
1.000E0
 1 59
38 hsa-miR-3156-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.825E-3 4.791E-2
2.844E-1
1.000E0
 1 64
39 hsa-miR-513b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.511E-3 4.791E-2
2.844E-1
1.000E0
 1 69
40 hsa-miR-654-3p:Functional MTI Functional MTI miRTarbase 9.648E-3 4.791E-2
2.844E-1
1.000E0
 1 70
41 hsa-miR-6823-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.785E-3 4.791E-2
2.844E-1
1.000E0
 1 71
42 hsa-miR-1247:mirSVR highEffct hsa-miR-1247:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.006E-2 4.791E-2
2.844E-1
1.000E0
 1 73
43 hsa-miR-92b*:mirSVR highEffct hsa-miR-92b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.033E-2 4.791E-2
2.844E-1
1.000E0
 1 75
44 hsa-miR-2114-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.033E-2 4.791E-2
2.844E-1
1.000E0
 1 75
45 hsa-miR-5702:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.033E-2 4.791E-2
2.844E-1
1.000E0
 1 75
46 hsa-miR-6852-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.047E-2 4.791E-2
2.844E-1
1.000E0
 1 76
47 hsa-miR-3909:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 4.791E-2
2.844E-1
1.000E0
 1 81
48 hsa-miR-937-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.143E-2 4.791E-2
2.844E-1
1.000E0
 1 83
49 hsa-miR-6842-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.170E-2 4.791E-2
2.844E-1
1.000E0
 1 85
50 hsa-miR-6509-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.239E-2 4.791E-2
2.844E-1
1.000E0
 1 90
Show 45 more annotations

17: Drug [Display Chart] 10 input genes in category / 2763 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000853 thryroxine Stitch 1.084E-16 2.995E-13 2.546E-12 2.995E-13 9 302
2 CID000000807 iodine Stitch 1.468E-14 2.028E-11 1.724E-10 4.057E-11 7 125
3 CID000004875 potassium iodide Stitch 7.408E-12 6.822E-9 5.800E-8 2.047E-8 5 47
4 CID000005238 sodium iodide Stitch 2.412E-11 1.666E-8 1.417E-7 6.665E-8 5 59
5 CID000445278 Ts-I Stitch 8.292E-11 4.582E-8 3.896E-7 2.291E-7 5 75
6 CID000024247 perchlorate Stitch 2.106E-10 9.697E-8 8.244E-7 5.818E-7 5 90
7 ctd:C005445 triphenyl phosphate CTD 9.471E-10 3.738E-7 3.178E-6 2.617E-6 5 121
8 CID001349907 methimazole Stitch 1.162E-9 4.015E-7 3.413E-6 3.212E-6 5 126
9 ctd:D005576 Colforsin CTD 1.392E-9 4.274E-7 3.634E-6 3.847E-6 6 318
10 CID000657298 propylthiouracil Stitch 1.648E-9 4.552E-7 3.870E-6 4.552E-6 5 135
11 ctd:C580599 6-OH-BDE-47 CTD 2.113E-9 4.896E-7 4.163E-6 5.838E-6 3 7
12 CID000002443 alpha-bromoergocriptine Stitch 2.126E-9 4.896E-7 4.163E-6 5.875E-6 5 142
13 CID000000861 D-triiodothyronine Stitch 6.282E-9 1.335E-6 1.135E-5 1.736E-5 6 409
14 CID000516900 potassium perchlorate Stitch 1.327E-8 2.618E-6 2.226E-5 3.666E-5 3 12
15 CID000006261 1-methyl-2-nitro-1-nitrosoguanidine Stitch 2.844E-8 5.240E-6 4.454E-5 7.859E-5 5 238
16 ctd:D000242 Cyclic AMP CTD 3.937E-8 6.799E-6 5.780E-5 1.088E-4 5 254
17 CID000449422 bis-amidinium derivative of hoechst 33258 Stitch 5.308E-8 8.626E-6 7.334E-5 1.466E-4 4 93
18 CID000056052 ractopamine Stitch 1.383E-7 2.123E-5 1.805E-4 3.821E-4 3 25
19 ctd:D002046 Bupranolol CTD 1.725E-7 2.509E-5 2.133E-4 4.767E-4 2 2
20 ctd:C098320 efavirenz CTD 2.195E-7 2.697E-5 2.293E-4 6.065E-4 3 29
21 ctd:D013974 Thyroxine CTD 3.356E-7 2.697E-5 2.293E-4 9.272E-4 4 147
22 CID000123143 phen-oxy Stitch 3.590E-7 2.697E-5 2.293E-4 9.920E-4 3 34
23 CID000208898 dronedarone Stitch 4.282E-7 2.697E-5 2.293E-4 1.183E-3 3 36
24 CID000002156 amiodarone Stitch 4.713E-7 2.697E-5 2.293E-4 1.302E-3 4 160
25 CID005287445 AC1NR9P8 Stitch 5.057E-7 2.697E-5 2.293E-4 1.397E-3 3 38
26 ctd:C076559 arbutamine CTD 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
27 CID000133262 p-azidobenzylcarazolol Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
28 CID000134388 U-43,465F Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
29 CID000065484 exaprolol Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
30 CID000125252 BAM-CYP Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
31 ctd:C568515 N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide CTD 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
32 CID003035819 p-azidoclonidine Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
33 CID000130141 H 216/44 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
34 CID000068838 butofilolol Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
35 CID003036190 ICYP-azide-2 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
36 CID000126676 pBABC Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
37 CID000133046 LCB 2183 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
38 ctd:C045916 broxaterol CTD 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
39 DB08808 Bupranolol Drug Bank 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
40 CID000193350 AC1L4W2Z Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
41 CID000133837 ICYP-azide-1 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
42 CID000054961 AHR-9377 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
43 CID003047798 Oberadilol Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
44 CID000015072 dicyclopropyl ketoxime Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
45 CID003037493 EXP063 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
46 DB01102 Arbutamine Drug Bank 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
47 CID000100459 CS 476 Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
48 CID000068811 soquinolol Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
49 CID003081105 CGP-12177-NBD Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
50 CID000133861 ADATN Stitch 5.174E-7 2.697E-5 2.293E-4 1.430E-3 2 3
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 547 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0010308 Congenital Hypothyroidism DisGeNET Curated 7.861E-17 4.300E-14 2.959E-13 4.300E-14 7 44
2 C0271829 Pendred's syndrome DisGeNET Curated 4.521E-16 1.236E-13 8.509E-13 2.473E-13 6 21
3 C0018021 Goiter DisGeNET Curated 2.312E-13 4.216E-11 2.902E-10 1.265E-10 5 18
4 C0917799 Hypersomnia DisGeNET Curated 3.137E-13 4.290E-11 2.953E-10 1.716E-10 5 19
5 C0020676 Hypothyroidism DisGeNET Curated 1.384E-12 1.515E-10 1.042E-9 7.573E-10 7 169
6 C0342162 Compensated hypothyroidism DisGeNET Curated 2.557E-12 2.331E-10 1.604E-9 1.399E-9 4 7
7 C0349476 Congenital goiter DisGeNET BeFree 9.199E-12 7.188E-10 4.947E-9 5.032E-9 4 9
8 C0000731 Abdomen distended DisGeNET Curated 2.581E-11 1.765E-9 1.215E-8 1.412E-8 5 43
9 C4072820 Large bregma sutures DisGeNET Curated 4.109E-11 1.873E-9 1.289E-8 2.248E-8 5 47
10 C4072821 Large, late-closing fontanelle DisGeNET Curated 4.109E-11 1.873E-9 1.289E-8 2.248E-8 5 47
11 C0456132 Large fontanelle DisGeNET Curated 4.109E-11 1.873E-9 1.289E-8 2.248E-8 5 47
12 C4072822 Wide bregma sutures DisGeNET Curated 4.109E-11 1.873E-9 1.289E-8 2.248E-8 5 47
13 C0018213 Graves Disease DisGeNET Curated 1.146E-10 4.820E-9 3.318E-8 6.266E-8 7 316
14 C0024421 Macroglossia DisGeNET Curated 2.777E-10 1.085E-8 7.468E-8 1.519E-7 5 68
15 C0342191 Familial dyshormonogenetic goiter DisGeNET BeFree 6.767E-10 2.468E-8 1.698E-7 3.701E-7 3 4
16 C4072825 Thickened facial skin with coarse facial features DisGeNET Curated 3.080E-9 9.909E-8 6.820E-7 1.685E-6 5 109
17 C1845847 Coarse facial features DisGeNET Curated 3.080E-9 9.909E-8 6.820E-7 1.685E-6 5 109
18 C1848805 Thyroid Dyshormonogenesis 1 DisGeNET Curated 3.381E-9 1.028E-7 7.072E-7 1.850E-6 3 6
19 C0040128 Thyroid Diseases DisGeNET Curated 4.601E-9 1.325E-7 9.118E-7 2.517E-6 5 118
20 C0022346 Icterus DisGeNET Curated 8.106E-9 2.217E-7 1.526E-6 4.434E-6 5 132
21 C1337013 Differentiated Thyroid Gland Carcinoma DisGeNET BeFree 8.744E-9 2.278E-7 1.568E-6 4.783E-6 5 134
22 C0586553 Raised TSH level DisGeNET Curated 9.461E-9 2.352E-7 1.619E-6 5.175E-6 3 8
23 C0237326 Dyschezia DisGeNET Curated 1.052E-8 2.501E-7 1.721E-6 5.753E-6 5 139
24 C0205696 Anaplastic carcinoma DisGeNET BeFree 1.404E-8 3.200E-7 2.203E-6 7.681E-6 4 48
25 C0009806 Constipation DisGeNET Curated 2.567E-8 5.618E-7 3.866E-6 1.404E-5 5 166
26 C0271790 Subclinical hypothyroidism DisGeNET BeFree 2.785E-8 5.859E-7 4.033E-6 1.523E-5 3 11
27 C1563716 Thyroid Dysgenesis DisGeNET Curated 3.712E-8 7.520E-7 5.176E-6 2.031E-5 3 12
28 C0007133 Carcinoma, Papillary DisGeNET BeFree 3.853E-8 7.528E-7 5.181E-6 2.108E-5 5 180
29 C1266050 Poorly Differentiated Thyroid Carcinoma DisGeNET BeFree 9.437E-8 1.780E-6 1.225E-5 5.162E-5 3 16
30 C0040156 Thyrotoxicosis DisGeNET Curated 1.146E-7 2.089E-6 1.438E-5 6.266E-5 3 17
31 C0019322 Umbilical hernia DisGeNET Curated 1.189E-7 2.098E-6 1.444E-5 6.503E-5 4 81
32 C0178468 Autoimmune thyroid disease DisGeNET BeFree 2.464E-7 4.212E-6 2.899E-5 1.348E-4 4 97
33 C0015672 Fatigue DisGeNET Curated 3.367E-7 5.581E-6 3.841E-5 1.842E-4 5 278
34 C0040136 Thyroid Neoplasm DisGeNET Curated 8.608E-7 1.385E-5 9.531E-5 4.708E-4 5 336
35 C0342208 Multinodular goiter DisGeNET Curated 1.003E-6 1.562E-5 1.075E-4 5.484E-4 3 34
36 C0271791 Severe hypothyroidism DisGeNET BeFree 1.028E-6 1.562E-5 1.075E-4 5.623E-4 2 3
37 C1869118 HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS DisGeNET Curated 2.055E-6 2.958E-5 2.036E-4 1.124E-3 2 4
38 C0302840 Toxic thyroid adenoma DisGeNET BeFree 2.055E-6 2.958E-5 2.036E-4 1.124E-3 2 4
39 C0677607 Hashimoto Disease DisGeNET Curated 2.230E-6 3.127E-5 2.152E-4 1.220E-3 4 168
40 C0206682 Follicular thyroid carcinoma DisGeNET Curated 2.337E-6 3.196E-5 2.200E-4 1.279E-3 4 170
41 C0151516 Thyroid Hypoplasia DisGeNET Curated 3.424E-6 4.162E-5 2.865E-4 1.873E-3 2 5
42 C0038478 Struma Ovarii DisGeNET BeFree 3.424E-6 4.162E-5 2.865E-4 1.873E-3 2 5
43 C0302859 Euthyroid Goiter DisGeNET Curated 3.424E-6 4.162E-5 2.865E-4 1.873E-3 2 5
44 C4020805 Athyroidal hypothyroidism DisGeNET Curated 3.424E-6 4.162E-5 2.865E-4 1.873E-3 2 5
45 C3493776 HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 1 DisGeNET Curated 3.424E-6 4.162E-5 2.865E-4 1.873E-3 2 5
46 C0040137 Thyroid Nodule DisGeNET BeFree 4.866E-6 5.786E-5 3.982E-4 2.661E-3 3 57
47 C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 4.976E-6 5.792E-5 3.986E-4 2.722E-3 5 480
48 C0749420 Thyroid Agenesis DisGeNET Curated 5.134E-6 5.851E-5 4.027E-4 2.809E-3 2 6
49 C0238462 Medullary carcinoma of thyroid DisGeNET Curated 8.597E-6 9.597E-5 6.605E-4 4.703E-3 4 236
50 C1304508 Spindle cell hemangioma DisGeNET BeFree 9.578E-6 1.048E-4 7.212E-4 5.239E-3 2 8
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