Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc135_32, positive side

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1: GO: Molecular Function [Display Chart] 32 input genes in category / 135 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035591 signaling adaptor activity 3.923E-19 5.296E-17 2.906E-16 5.296E-17 11 78
2 GO:0005070 SH3/SH2 adaptor activity 1.046E-18 7.061E-17 3.874E-16 1.412E-16 10 54
3 GO:0030674 protein binding, bridging 1.768E-15 7.957E-14 4.365E-13 2.387E-13 11 163
4 GO:0060090 molecular adaptor activity 5.689E-15 1.920E-13 1.053E-12 7.680E-13 11 181
5 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1.102E-12 2.975E-11 1.632E-10 1.488E-10 7 46
6 GO:0004713 protein tyrosine kinase activity 6.042E-10 1.360E-8 7.459E-8 8.157E-8 8 182
7 GO:0015057 thrombin-activated receptor activity 4.570E-8 8.813E-7 4.835E-6 6.169E-6 3 5
8 GO:0005085 guanyl-nucleotide exchange factor activity 7.048E-7 1.189E-5 6.525E-5 9.515E-5 7 306
9 GO:0030971 receptor tyrosine kinase binding 3.246E-6 4.869E-5 2.671E-4 4.382E-4 4 60
10 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 3.704E-6 5.001E-5 2.743E-4 5.001E-4 4 62
11 GO:1990782 protein tyrosine kinase binding 4.763E-6 5.845E-5 3.207E-4 6.430E-4 4 66
12 GO:0052813 phosphatidylinositol bisphosphate kinase activity 6.750E-6 7.593E-5 4.166E-4 9.112E-4 4 72
13 GO:0035004 phosphatidylinositol 3-kinase activity 8.825E-6 8.723E-5 4.786E-4 1.191E-3 4 77
14 GO:0005086 ARF guanyl-nucleotide exchange factor activity 9.046E-6 8.723E-5 4.786E-4 1.221E-3 3 24
15 GO:0046875 ephrin receptor binding 1.624E-5 1.461E-4 8.017E-4 2.192E-3 3 29
16 GO:0032795 heterotrimeric G-protein binding 4.255E-5 3.590E-4 1.970E-3 5.744E-3 2 6
17 GO:0005168 neurotrophin TRKA receptor binding 5.951E-5 4.665E-4 2.559E-3 8.033E-3 2 7
18 GO:0003779 actin binding 6.220E-5 4.665E-4 2.559E-3 8.397E-3 6 412
19 GO:0005167 neurotrophin TRK receptor binding 7.926E-5 5.631E-4 3.089E-3 1.070E-2 2 8
20 GO:0070851 growth factor receptor binding 1.006E-4 6.792E-4 3.726E-3 1.358E-2 4 143
21 GO:0031681 G-protein beta-subunit binding 1.860E-4 1.046E-3 5.740E-3 2.511E-2 2 12
22 GO:0043560 insulin receptor substrate binding 1.860E-4 1.046E-3 5.740E-3 2.511E-2 2 12
23 GO:0005522 profilin binding 1.860E-4 1.046E-3 5.740E-3 2.511E-2 2 12
24 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1.860E-4 1.046E-3 5.740E-3 2.511E-2 2 12
25 GO:0005165 neurotrophin receptor binding 2.559E-4 1.382E-3 7.582E-3 3.455E-2 2 14
26 GO:0051219 phosphoprotein binding 3.193E-4 1.658E-3 9.096E-3 4.311E-2 3 78
27 GO:0008093 cytoskeletal adaptor activity 3.368E-4 1.684E-3 9.238E-3 4.546E-2 2 16
28 GO:0005161 platelet-derived growth factor receptor binding 3.813E-4 1.838E-3 1.008E-2
5.147E-2
 2 17
29 GO:0001784 phosphotyrosine residue binding 4.285E-4 1.995E-3 1.094E-2
5.784E-2
 2 18
30 GO:0070064 proline-rich region binding 5.309E-4 2.389E-3 1.311E-2
7.168E-2
 2 20
31 GO:0030159 receptor signaling complex scaffold activity 9.024E-4 3.807E-3 2.089E-2
1.218E-1
 2 26
32 GO:0003785 actin monomer binding 9.024E-4 3.807E-3 2.089E-2
1.218E-1
 2 26
33 GO:0045309 protein phosphorylated amino acid binding 1.047E-3 4.284E-3 2.350E-2
1.414E-1
 2 28
34 GO:0001965 G-protein alpha-subunit binding 1.455E-3 5.538E-3 3.038E-2
1.964E-1
 2 33
35 GO:0051015 actin filament binding 1.477E-3 5.538E-3 3.038E-2
1.994E-1
 3 132
36 GO:0008528 G protein-coupled peptide receptor activity 1.477E-3 5.538E-3 3.038E-2
1.994E-1
 3 132
37 GO:0005158 insulin receptor binding 1.544E-3 5.596E-3 3.070E-2
2.085E-1
 2 34
38 GO:0001653 peptide receptor activity 1.575E-3 5.596E-3 3.070E-2
2.126E-1
 3 135
39 GO:0019903 protein phosphatase binding 1.820E-3 6.301E-3 3.457E-2
2.457E-1
 3 142
40 GO:0043548 phosphatidylinositol 3-kinase binding 1.927E-3 6.504E-3 3.568E-2
2.601E-1
 2 38
41 GO:0016303 1-phosphatidylinositol-3-kinase activity 2.462E-3 8.107E-3 4.447E-2
3.324E-1
 2 43
42 GO:0042610 CD8 receptor binding 3.427E-3 1.082E-2
5.937E-2
4.626E-1
 1 2
43 GO:0030145 manganese ion binding 3.447E-3 1.082E-2
5.937E-2
4.653E-1
 2 51
44 GO:0019902 phosphatase binding 3.966E-3 1.217E-2
6.676E-2
5.354E-1
 3 187
45 GO:0052742 phosphatidylinositol kinase activity 4.435E-3 1.331E-2
7.300E-2
5.988E-1
 2 58
46 GO:0043423 3-phosphoinositide-dependent protein kinase binding 5.136E-3 1.492E-2
8.186E-2
6.933E-1
 1 3
47 GO:0000287 magnesium ion binding 5.195E-3 1.492E-2
8.186E-2
7.013E-1
 3 206
48 GO:0019207 kinase regulator activity 5.924E-3 1.666E-2
9.140E-2
7.997E-1
 3 216
49 GO:0004515 nicotinate-nucleotide adenylyltransferase activity 6.842E-3 1.847E-2
1.014E-1
9.237E-1
 1 4
50 GO:0071074 eukaryotic initiation factor eIF2 binding 6.842E-3 1.847E-2
1.014E-1
9.237E-1
 1 4
Show 45 more annotations

2: GO: Biological Process [Display Chart] 32 input genes in category / 1479 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007015 actin filament organization 1.505E-16 1.320E-13 1.040E-12 2.225E-13 14 345
2 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 2.755E-16 1.320E-13 1.040E-12 4.074E-13 10 91
3 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 2.755E-16 1.320E-13 1.040E-12 4.074E-13 10 91
4 GO:0038094 Fc-gamma receptor signaling pathway 4.313E-16 1.320E-13 1.040E-12 6.378E-13 10 95
5 GO:0038093 Fc receptor signaling pathway 4.521E-16 1.320E-13 1.040E-12 6.687E-13 12 206
6 GO:0002431 Fc receptor mediated stimulatory signaling pathway 5.356E-16 1.320E-13 1.040E-12 7.921E-13 10 97
7 GO:0032956 regulation of actin cytoskeleton organization 1.093E-15 2.309E-13 1.818E-12 1.616E-12 13 302
8 GO:0002429 immune response-activating cell surface receptor signaling pathway 3.725E-15 6.886E-13 5.424E-12 5.509E-12 13 332
9 GO:0032970 regulation of actin filament-based process 5.464E-15 8.784E-13 6.919E-12 8.081E-12 13 342
10 GO:0006909 phagocytosis 5.939E-15 8.784E-13 6.919E-12 8.784E-12 12 255
11 GO:0002757 immune response-activating signal transduction 1.001E-14 1.345E-12 1.060E-11 1.480E-11 14 467
12 GO:0008154 actin polymerization or depolymerization 1.120E-14 1.381E-12 1.088E-11 1.657E-11 11 192
13 GO:0002768 immune response-regulating cell surface receptor signaling pathway 1.309E-14 1.490E-12 1.173E-11 1.936E-11 13 366
14 GO:0048010 vascular endothelial growth factor receptor signaling pathway 5.394E-14 5.698E-12 4.488E-11 7.978E-11 9 98
15 GO:0008064 regulation of actin polymerization or depolymerization 1.481E-13 1.454E-11 1.145E-10 2.191E-10 10 168
16 GO:0030832 regulation of actin filament length 1.573E-13 1.454E-11 1.145E-10 2.326E-10 10 169
17 GO:0051493 regulation of cytoskeleton organization 1.952E-13 1.698E-11 1.338E-10 2.887E-10 13 452
18 GO:0032271 regulation of protein polymerization 3.507E-13 2.882E-11 2.270E-10 5.187E-10 10 183
19 GO:0032535 regulation of cellular component size 6.242E-13 4.859E-11 3.827E-10 9.232E-10 12 377
20 GO:0018108 peptidyl-tyrosine phosphorylation 7.996E-13 5.913E-11 4.658E-10 1.183E-9 12 385
21 GO:0018212 peptidyl-tyrosine modification 8.500E-13 5.986E-11 4.715E-10 1.257E-9 12 387
22 GO:0038083 peptidyl-tyrosine autophosphorylation 1.312E-12 8.818E-11 6.946E-10 1.940E-9 7 47
23 GO:0030833 regulation of actin filament polymerization 2.375E-12 1.527E-10 1.203E-9 3.512E-9 9 148
24 GO:0051258 protein polymerization 5.963E-12 3.563E-10 2.806E-9 8.819E-9 10 243
25 GO:0030041 actin filament polymerization 6.022E-12 3.563E-10 2.806E-9 8.907E-9 9 164
26 GO:0022407 regulation of cell-cell adhesion 7.304E-11 4.155E-9 3.273E-8 1.080E-7 11 430
27 GO:0050870 positive regulation of T cell activation 1.302E-10 7.021E-9 5.530E-8 1.925E-7 9 231
28 GO:0007265 Ras protein signal transduction 1.329E-10 7.021E-9 5.530E-8 1.966E-7 10 333
29 GO:0034112 positive regulation of homotypic cell-cell adhesion 1.575E-10 8.033E-9 6.327E-8 2.330E-7 9 236
30 GO:0002696 positive regulation of leukocyte activation 1.676E-10 8.263E-9 6.509E-8 2.479E-7 10 341
31 GO:1903039 positive regulation of leukocyte cell-cell adhesion 1.829E-10 8.725E-9 6.873E-8 2.705E-7 9 240
32 GO:0030838 positive regulation of actin filament polymerization 2.020E-10 9.335E-9 7.353E-8 2.987E-7 7 94
33 GO:0050867 positive regulation of cell activation 2.414E-10 1.082E-8 8.523E-8 3.571E-7 10 354
34 GO:0022409 positive regulation of cell-cell adhesion 6.304E-10 2.742E-8 2.160E-7 9.323E-7 9 276
35 GO:0043254 regulation of protein complex assembly 7.907E-10 3.341E-8 2.632E-7 1.169E-6 10 400
36 GO:0032273 positive regulation of protein polymerization 8.434E-10 3.465E-8 2.729E-7 1.247E-6 7 115
37 GO:0051495 positive regulation of cytoskeleton organization 1.061E-9 4.243E-8 3.342E-7 1.570E-6 8 195
38 GO:0045785 positive regulation of cell adhesion 1.420E-9 5.528E-8 4.354E-7 2.101E-6 10 425
39 GO:0051251 positive regulation of lymphocyte activation 1.802E-9 6.832E-8 5.381E-7 2.665E-6 9 311
40 GO:0007173 epidermal growth factor receptor signaling pathway 2.224E-9 8.222E-8 6.476E-7 3.289E-6 7 132
41 GO:0050863 regulation of T cell activation 2.795E-9 1.008E-7 7.942E-7 4.134E-6 9 327
42 GO:1903037 regulation of leukocyte cell-cell adhesion 4.031E-9 1.420E-7 1.118E-6 5.962E-6 9 341
43 GO:0050851 antigen receptor-mediated signaling pathway 4.323E-9 1.487E-7 1.171E-6 6.394E-6 8 233
44 GO:0034110 regulation of homotypic cell-cell adhesion 4.812E-9 1.618E-7 1.274E-6 7.118E-6 9 348
45 GO:0038127 ERBB signaling pathway 5.690E-9 1.870E-7 1.473E-6 8.415E-6 7 151
46 GO:0030098 lymphocyte differentiation 5.866E-9 1.886E-7 1.485E-6 8.675E-6 9 356
47 GO:0014065 phosphatidylinositol 3-kinase signaling 1.146E-8 3.605E-7 2.840E-6 1.694E-5 7 167
48 GO:0050900 leukocyte migration 1.184E-8 3.648E-7 2.873E-6 1.751E-5 9 386
49 GO:0046632 alpha-beta T cell differentiation 1.303E-8 3.932E-7 3.097E-6 1.927E-5 6 96
50 GO:0034109 homotypic cell-cell adhesion 1.682E-8 4.976E-7 3.919E-6 2.488E-5 9 402
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 32 input genes in category / 110 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031252 cell leading edge 1.952E-11 2.147E-9 1.134E-8 2.147E-9 11 389
2 GO:0009898 cytoplasmic side of plasma membrane 2.837E-10 1.536E-8 8.114E-8 3.121E-8 8 169
3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 4.318E-10 1.536E-8 8.114E-8 4.750E-8 7 107
4 GO:0098562 cytoplasmic side of membrane 5.586E-10 1.536E-8 8.114E-8 6.144E-8 8 184
5 GO:0019897 extrinsic component of plasma membrane 5.083E-9 1.118E-7 5.907E-7 5.591E-7 7 152
6 GO:0019898 extrinsic component of membrane 1.438E-8 2.636E-7 1.392E-6 1.582E-6 8 278
7 GO:0005938 cell cortex 2.379E-7 3.739E-6 1.975E-5 2.617E-5 7 266
8 GO:0001726 ruffle 3.327E-7 4.575E-6 2.416E-5 3.660E-5 6 169
9 GO:0098794 postsynapse 5.702E-7 6.429E-6 3.396E-5 6.272E-5 8 449
10 GO:0030027 lamellipodium 5.844E-7 6.429E-6 3.396E-5 6.429E-5 6 186
11 GO:0099568 cytoplasmic region 9.165E-7 9.165E-6 4.841E-5 1.008E-4 7 325
12 GO:0015629 actin cytoskeleton 1.135E-5 1.038E-4 5.485E-4 1.249E-3 7 476
13 GO:0030426 growth cone 1.227E-5 1.038E-4 5.485E-4 1.350E-3 5 182
14 GO:0030427 site of polarized growth 1.399E-5 1.099E-4 5.806E-4 1.539E-3 5 187
15 GO:0030863 cortical cytoskeleton 2.031E-5 1.490E-4 7.869E-4 2.234E-3 4 97
16 GO:0014069 postsynaptic density 3.940E-5 2.549E-4 1.347E-3 4.334E-3 5 232
17 GO:0099572 postsynaptic specialization 3.940E-5 2.549E-4 1.347E-3 4.334E-3 5 232
18 GO:0060076 excitatory synapse 5.838E-5 3.568E-4 1.885E-3 6.422E-3 5 252
19 GO:0044448 cell cortex part 8.080E-5 4.678E-4 2.471E-3 8.888E-3 4 138
20 GO:0017146 NMDA selective glutamate receptor complex 1.783E-4 9.808E-4 5.181E-3 1.962E-2 2 12
21 GO:0030864 cortical actin cytoskeleton 2.000E-4 1.048E-3 5.534E-3 2.200E-2 3 68
22 GO:0001891 phagocytic cup 4.587E-4 2.293E-3 1.211E-2
5.045E-2
 2 19
23 GO:0005884 actin filament 5.193E-4 2.484E-3 1.312E-2
5.713E-2
 3 94
24 GO:0005911 cell-cell junction 6.118E-4 2.804E-3 1.481E-2
6.730E-2
 5 418
25 GO:1990578 perinuclear endoplasmic reticulum membrane 1.679E-3 7.387E-3 3.902E-2
1.847E-1
 1 1
26 GO:0008328 ionotropic glutamate receptor complex 3.181E-3 1.274E-2
6.729E-2
3.499E-1
 2 50
27 GO:0070436 Grb2-EGFR complex 3.355E-3 1.274E-2
6.729E-2
3.690E-1
 1 2
28 GO:0005943 phosphatidylinositol 3-kinase complex, class IA 3.355E-3 1.274E-2
6.729E-2
3.690E-1
 1 2
29 GO:0098802 plasma membrane receptor complex 3.359E-3 1.274E-2
6.729E-2
3.694E-1
 3 180
30 GO:0061645 endocytic patch 5.028E-3 1.784E-2
9.425E-2
5.531E-1
 1 3
31 GO:0030479 actin cortical patch 5.028E-3 1.784E-2
9.425E-2
5.531E-1
 1 3
32 GO:0005802 trans-Golgi network 5.587E-3 1.921E-2
1.015E-1
6.146E-1
 3 216
33 GO:0005853 eukaryotic translation elongation factor 1 complex 6.699E-3 2.105E-2
1.112E-1
7.369E-1
 1 4
34 GO:0019815 B cell receptor complex 6.699E-3 2.105E-2
1.112E-1
7.369E-1
 1 4
35 GO:0030478 actin cap 6.699E-3 2.105E-2
1.112E-1
7.369E-1
 1 4
36 GO:0097651 phosphatidylinositol 3-kinase complex, class I 8.367E-3 2.557E-2
1.350E-1
9.204E-1
 1 5
37 GO:0032587 ruffle membrane 8.736E-3 2.597E-2
1.372E-1
9.610E-1
 2 84
38 GO:0032009 early phagosome 1.003E-2 2.830E-2
1.495E-1
1.000E0
 1 6
39 GO:0005826 actomyosin contractile ring 1.003E-2 2.830E-2
1.495E-1
1.000E0
 1 6
40 GO:0034702 ion channel complex 1.260E-2 3.464E-2
1.830E-1
1.000E0
 3 291
41 GO:0031209 SCAR complex 1.335E-2 3.583E-2
1.893E-1
1.000E0
 1 8
42 GO:0098791 Golgi subcompartment 1.704E-2 4.144E-2
2.189E-1
1.000E0
 3 326
43 GO:1902495 transmembrane transporter complex 1.718E-2 4.144E-2
2.189E-1
1.000E0
 3 327
44 GO:1990351 transporter complex 1.803E-2 4.144E-2
2.189E-1
1.000E0
 3 333
45 GO:0031094 platelet dense tubular network 1.832E-2 4.144E-2
2.189E-1
1.000E0
 1 11
46 GO:1990023 mitotic spindle midzone 1.832E-2 4.144E-2
2.189E-1
1.000E0
 1 11
47 GO:0043235 receptor complex 1.889E-2 4.144E-2
2.189E-1
1.000E0
 3 339
48 GO:0031984 organelle subcompartment 1.919E-2 4.144E-2
2.189E-1
1.000E0
 3 341
49 GO:0045121 membrane raft 1.948E-2 4.144E-2
2.189E-1
1.000E0
 3 343
50 GO:0098857 membrane microdomain 1.948E-2 4.144E-2
2.189E-1
1.000E0
 3 343
Show 45 more annotations

4: Human Phenotype [Display Chart] 9 input genes in category / 793 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 30 input genes in category / 1132 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000715 decreased thymocyte number 3.891E-8 4.405E-5 3.352E-4 4.405E-5 8 186
2 MP:0008215 decreased immature B cell number 2.293E-6 1.107E-3 8.423E-3 2.596E-3 6 138
3 MP:0004179 transmission ratio distortion 4.388E-6 1.107E-3 8.423E-3 4.967E-3 4 39
4 MP:0008073 abnormal CD4-positive, alpha beta T cell number 4.615E-6 1.107E-3 8.423E-3 5.224E-3 9 470
5 MP:0002357 abnormal spleen white pulp morphology 5.327E-6 1.107E-3 8.423E-3 6.030E-3 8 355
6 MP:0005017 decreased B cell number 5.867E-6 1.107E-3 8.423E-3 6.641E-3 9 484
7 MP:0013701 abnormal mature B cell number 7.229E-6 1.123E-3 8.548E-3 8.183E-3 8 370
8 MP:0013664 abnormal immature B cell number 7.939E-6 1.123E-3 8.548E-3 8.986E-3 6 171
9 MP:0005022 abnormal immature B cell morphology 9.994E-6 1.257E-3 9.565E-3 1.131E-2 6 178
10 MP:0003720 abnormal neural tube closure 1.146E-5 1.262E-3 9.601E-3 1.298E-2 8 394
11 MP:0008211 decreased mature B cell number 1.226E-5 1.262E-3 9.601E-3 1.388E-2 7 282
12 MP:0000523 cortical renal glomerulopathies 1.408E-5 1.328E-3 1.011E-2 1.594E-2 6 189
13 MP:0008049 increased memory T cell number 2.003E-5 1.744E-3 1.327E-2 2.267E-2 5 118
14 MP:0009657 failure of chorioallantoic fusion 3.642E-5 2.748E-3 2.091E-2 4.122E-2 4 66
15 MP:0010838 increased CD8-positive, alpha-beta memory T cell number 3.642E-5 2.748E-3 2.091E-2 4.122E-2 4 66
16 MP:0000292 distended pericardium 4.098E-5 2.835E-3 2.157E-2 4.639E-2 4 68
17 MP:0002460 decreased immunoglobulin level 4.257E-5 2.835E-3 2.157E-2 4.819E-2 7 342
18 MP:0002762 ectopic cerebellar granule cells 4.835E-5 3.016E-3 2.295E-2
5.473E-2
 3 25
19 MP:0001802 arrested B cell differentiation 5.136E-5 3.016E-3 2.295E-2
5.814E-2
 4 72
20 MP:0002494 increased IgM level 5.765E-5 3.016E-3 2.295E-2
6.526E-2
 5 147
21 MP:0020180 abnormal IgM level 5.810E-5 3.016E-3 2.295E-2
6.577E-2
 6 243
22 MP:0009919 abnormal transitional stage T1 B cell morphology 6.125E-5 3.016E-3 2.295E-2
6.933E-2
 3 27
23 MP:0009926 decreased transitional stage T2 B cell number 6.846E-5 3.016E-3 2.295E-2
7.750E-2
 3 28
24 MP:0001712 abnormal placenta development 6.975E-5 3.016E-3 2.295E-2
7.896E-2
 5 153
25 MP:0011723 ectopic neuron 7.036E-5 3.016E-3 2.295E-2
7.964E-2
 4 78
26 MP:0008688 decreased interleukin-2 secretion 7.036E-5 3.016E-3 2.295E-2
7.964E-2
 4 78
27 MP:0020173 abnormal IgE level 7.195E-5 3.016E-3 2.295E-2
8.144E-2
 5 154
28 MP:0009268 absent cerebellum fissure 8.071E-5 3.184E-3 2.423E-2
9.136E-2
 2 5
29 MP:0005264 glomerulosclerosis 8.157E-5 3.184E-3 2.423E-2
9.234E-2
 4 81
30 MP:0009920 abnormal transitional stage T2 B cell morphology 8.452E-5 3.189E-3 2.427E-2
9.567E-2
 3 30
31 MP:0008048 abnormal memory T cell number 1.056E-4 3.704E-3 2.819E-2
1.196E-1
 5 167
32 MP:0010833 abnormal memory T cell morphology 1.087E-4 3.704E-3 2.819E-2
1.230E-1
 5 168
33 MP:0010837 abnormal CD8-positive, alpha-beta memory T cell morphology 1.127E-4 3.704E-3 2.819E-2
1.276E-1
 4 88
34 MP:0012774 abnormal CD8-positive, alpha-beta memory T cell number 1.127E-4 3.704E-3 2.819E-2
1.276E-1
 4 88
35 MP:0008077 abnormal CD8-positive, alpha-beta T cell number 1.146E-4 3.704E-3 2.819E-2
1.298E-1
 7 400
36 MP:0008083 decreased single-positive T cell number 1.178E-4 3.704E-3 2.819E-2
1.333E-1
 4 89
37 MP:0010038 abnormal placenta physiology 1.248E-4 3.817E-3 2.905E-2
1.412E-1
 5 173
38 MP:0002824 abnormal chorioallantoic fusion 1.284E-4 3.826E-3 2.911E-2
1.454E-1
 4 91
39 MP:0008036 abnormal NK T cell morphology 1.397E-4 3.954E-3 3.009E-2
1.582E-1
 4 93
40 MP:0008038 abnormal NK T cell number 1.397E-4 3.954E-3 3.009E-2
1.582E-1
 4 93
41 MP:0005153 abnormal B cell proliferation 1.625E-4 4.147E-3 3.156E-2
1.839E-1
 5 183
42 MP:0004712 notochord degeneration 1.689E-4 4.147E-3 3.156E-2
1.912E-1
 2 7
43 MP:0006098 absent cerebellar lobules 1.689E-4 4.147E-3 3.156E-2
1.912E-1
 2 7
44 MP:0011856 abnormal glomerular filtration barrier function 1.689E-4 4.147E-3 3.156E-2
1.912E-1
 2 7
45 MP:0012543 abnormal rostral neuropore morphology 1.712E-4 4.147E-3 3.156E-2
1.937E-1
 4 98
46 MP:0000928 incomplete rostral neuropore closure 1.712E-4 4.147E-3 3.156E-2
1.937E-1
 4 98
47 MP:0005010 abnormal CD8-positive, alpha beta T cell morphology 1.722E-4 4.147E-3 3.156E-2
1.949E-1
 7 427
48 MP:0008182 decreased marginal zone B cell number 1.850E-4 4.353E-3 3.313E-2
2.095E-1
 4 100
49 MP:0006315 abnormal urine protein level 1.889E-4 4.353E-3 3.313E-2
2.139E-1
 5 189
50 MP:0012542 abnormal neuropore morphology 1.923E-4 4.353E-3 3.313E-2
2.177E-1
 4 101
Show 45 more annotations

6: Domain [Display Chart] 32 input genes in category / 183 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00017 SH2 Pfam 1.324E-33 2.423E-31 1.403E-30 2.423E-31 18 101
2 SM00252 SH2 SMART 7.030E-33 3.654E-31 2.115E-30 1.287E-30 18 110
3 PS50001 SH2 PROSITE 8.385E-33 3.654E-31 2.115E-30 1.534E-30 18 111
4 3.30.505.10 - Gene3D 9.983E-33 3.654E-31 2.115E-30 1.827E-30 18 112
5 IPR000980 SH2 InterPro 9.983E-33 3.654E-31 2.115E-30 1.827E-30 18 112
6 PF00018 SH3 1 Pfam 1.482E-29 4.521E-28 2.617E-27 2.712E-27 18 164
7 SM00326 SH3 SMART 2.813E-27 6.434E-26 3.725E-25 5.147E-25 18 217
8 PS50002 SH3 PROSITE 2.813E-27 6.434E-26 3.725E-25 5.147E-25 18 217
9 IPR001452 SH3 domain InterPro 3.949E-27 8.030E-26 4.649E-25 7.227E-25 18 221
10 PF07714 Pkinase Tyr Pfam 6.434E-13 1.177E-11 6.816E-11 1.177E-10 9 129
11 IPR001245 Ser-Thr/Tyr kinase cat dom InterPro 1.191E-12 1.982E-11 1.147E-10 2.180E-10 9 138
12 SM00219 TyrKc SMART 1.642E-12 2.311E-11 1.338E-10 3.004E-10 8 88
13 IPR020635 Tyr kinase cat dom InterPro 1.642E-12 2.311E-11 1.338E-10 3.004E-10 8 88
14 IPR008266 Tyr kinase AS InterPro 3.653E-12 4.457E-11 2.580E-10 6.686E-10 8 97
15 PS00109 PROTEIN KINASE TYR PROSITE 3.653E-12 4.457E-11 2.580E-10 6.686E-10 8 97
16 IPR003912 Protea act rcpt InterPro 1.808E-8 2.068E-7 1.197E-6 3.309E-6 3 4
17 PS00107 PROTEIN KINASE ATP PROSITE 5.000E-8 5.382E-7 3.116E-6 9.149E-6 9 459
18 IPR000719 Prot kinase dom InterPro 8.587E-8 8.730E-7 5.054E-6 1.571E-5 9 489
19 PS50011 PROTEIN KINASE DOM PROSITE 9.205E-8 8.866E-7 5.133E-6 1.684E-5 9 493
20 IPR017441 Protein kinase ATP BS InterPro 1.792E-7 1.640E-6 9.494E-6 3.280E-5 8 379
21 IPR011993 PH dom-like InterPro 4.439E-7 3.868E-6 2.239E-5 8.123E-5 8 427
22 SM00808 FABD SMART 2.826E-6 2.069E-5 1.198E-4 5.172E-4 2 2
23 IPR015015 F-actin binding InterPro 2.826E-6 2.069E-5 1.198E-4 5.172E-4 2 2
24 PF08919 F actin bind Pfam 2.826E-6 2.069E-5 1.198E-4 5.172E-4 2 2
25 IPR017304 NCK InterPro 2.826E-6 2.069E-5 1.198E-4 5.172E-4 2 2
26 2.30.29.30 - Gene3D 3.506E-6 2.468E-5 1.429E-4 6.416E-4 7 391
27 PS50003 PH DOMAIN PROSITE 6.904E-6 4.605E-5 2.666E-4 1.263E-3 6 280
28 IPR001849 PH domain InterPro 7.046E-6 4.605E-5 2.666E-4 1.289E-3 6 281
29 PF14604 SH3 9 Pfam 9.149E-6 5.773E-5 3.342E-4 1.674E-3 4 78
30 IPR001720 PI3kinase P85 InterPro 2.817E-5 1.719E-4 9.950E-4 5.156E-3 2 5
31 PF00169 PH Pfam 4.102E-5 2.422E-4 1.402E-3 7.507E-3 5 230
32 PS51113 ZF BTK PROSITE 1.010E-4 5.203E-4 3.012E-3 1.848E-2 2 9
33 PF00779 BTK Pfam 1.010E-4 5.203E-4 3.012E-3 1.848E-2 2 9
34 IPR001562 Znf Btk motif InterPro 1.010E-4 5.203E-4 3.012E-3 1.848E-2 2 9
35 SM00107 BTK SMART 1.010E-4 5.203E-4 3.012E-3 1.848E-2 2 9
36 SM00233 PH SMART 1.024E-4 5.203E-4 3.012E-3 1.873E-2 5 279
37 SM00246 WH2 SMART 2.539E-4 1.256E-3 7.271E-3 4.647E-2 2 14
38 IPR013315 Spectrin alpha SH3 InterPro 2.927E-4 1.409E-3 8.160E-3
5.356E-2
 2 15
39 PF02205 WH2 Pfam 3.341E-4 1.568E-3 9.077E-3
6.115E-2
 2 16
40 PF07653 SH3 2 Pfam 4.352E-4 1.943E-3 1.125E-2
7.964E-2
 3 87
41 IPR011511 SH3 2 InterPro 4.352E-4 1.943E-3 1.125E-2
7.964E-2
 3 87
42 IPR003124 WH2 dom InterPro 5.816E-4 2.534E-3 1.467E-2
1.064E-1
 2 21
43 PF00611 FCH Pfam 6.391E-4 2.658E-3 1.539E-2
1.170E-1
 2 22
44 SM00055 FCH SMART 6.391E-4 2.658E-3 1.539E-2
1.170E-1
 2 22
45 IPR001060 FCH dom InterPro 6.992E-4 2.844E-3 1.646E-2
1.280E-1
 2 23
46 PS51082 WH2 PROSITE 7.620E-4 3.031E-3 1.755E-2
1.394E-1
 2 24
47 PS51741 F BAR PROSITE 8.274E-4 3.154E-3 1.826E-2
1.514E-1
 2 25
48 IPR031160 F BAR InterPro 8.274E-4 3.154E-3 1.826E-2
1.514E-1
 2 25
49 IPR030777 PSTPIP1 InterPro 1.708E-3 4.961E-3 2.872E-2
3.126E-1
 1 1
50 IPR003944 Prot act rcpt 4 InterPro 1.708E-3 4.961E-3 2.872E-2
3.126E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 30 input genes in category / 562 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138071 PDGFR-beta signaling pathway BioSystems: Pathway Interaction Database 3.598E-15 2.022E-12 1.397E-11 2.022E-12 9 54
2 1269279 Fcgamma receptor (FCGR) dependent phagocytosis BioSystems: REACTOME 1.091E-14 3.066E-12 2.118E-11 6.131E-12 10 95
3 138050 Fc-epsilon receptor I signaling in mast cells BioSystems: Pathway Interaction Database 8.385E-13 1.571E-10 1.085E-9 4.712E-10 8 59
4 1269324 Regulation of signaling by CBL BioSystems: REACTOME 2.092E-12 2.939E-10 2.031E-9 1.176E-9 6 18
5 1269281 Regulation of actin dynamics for phagocytic cup formation BioSystems: REACTOME 3.508E-12 3.943E-10 2.725E-9 1.972E-9 8 70
6 138026 Insulin Pathway BioSystems: Pathway Interaction Database 6.739E-12 6.312E-10 4.361E-9 3.787E-9 7 43
7 138072 Nephrin/Neph1 signaling in the kidney podocyte BioSystems: Pathway Interaction Database 2.560E-11 2.055E-9 1.420E-8 1.439E-8 6 26
8 83080 T cell receptor signaling pathway BioSystems: KEGG 8.387E-11 5.892E-9 4.071E-8 4.713E-8 8 103
9 137940 Signaling events mediated by VEGFR1 and VEGFR2 BioSystems: Pathway Interaction Database 1.120E-10 6.994E-9 4.833E-8 6.295E-8 7 63
10 1269518 RHO GTPases Activate WASPs and WAVEs BioSystems: REACTOME 2.130E-10 1.197E-8 8.272E-8 1.197E-7 6 36
11 P00047 PDGF signaling pathway PantherDB 4.552E-10 2.326E-8 1.607E-7 2.558E-7 8 127
12 1269184 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers BioSystems: REACTOME 7.619E-10 3.568E-8 2.465E-7 4.282E-7 6 44
13 83049 ErbB signaling pathway BioSystems: KEGG 1.048E-9 4.530E-8 3.130E-7 5.889E-7 7 86
14 137917 Angiopoietin receptor Tie2-mediated signaling BioSystems: Pathway Interaction Database 1.316E-9 5.282E-8 3.649E-7 7.394E-7 6 48
15 1270243 Nephrin interactions BioSystems: REACTOME 1.464E-9 5.487E-8 3.791E-7 8.230E-7 5 22
16 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 2.168E-9 7.168E-8 4.953E-7 1.219E-6 6 52
17 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 2.168E-9 7.168E-8 4.953E-7 1.219E-6 6 52
18 169348 Signaling events mediated by focal adhesion kinase BioSystems: Pathway Interaction Database 2.742E-9 8.560E-8 5.915E-7 1.541E-6 6 54
19 1269483 VEGFA-VEGFR2 Pathway BioSystems: REACTOME 3.059E-9 8.633E-8 5.965E-7 1.719E-6 10 333
20 83103 Pathogenic Escherichia coli infection BioSystems: KEGG 3.072E-9 8.633E-8 5.965E-7 1.727E-6 6 55
21 1269480 Signaling by VEGF BioSystems: REACTOME 3.845E-9 1.029E-7 7.111E-7 2.161E-6 10 341
22 137998 TCR signaling in naive CD4+ T cells BioSystems: Pathway Interaction Database 5.262E-9 1.322E-7 9.135E-7 2.957E-6 6 60
23 137992 IGF1 pathway BioSystems: Pathway Interaction Database 5.411E-9 1.322E-7 9.135E-7 3.041E-6 5 28
24 1269178 CD28 co-stimulation BioSystems: REACTOME 1.296E-8 2.913E-7 2.013E-6 7.282E-6 5 33
25 138047 EPHB forward signaling BioSystems: Pathway Interaction Database 1.296E-8 2.913E-7 2.013E-6 7.282E-6 5 33
26 137930 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) BioSystems: Pathway Interaction Database 1.610E-8 3.480E-7 2.404E-6 9.047E-6 6 72
27 1269300 FCERI mediated Ca+2 mobilization BioSystems: REACTOME 2.048E-8 4.262E-7 2.945E-6 1.151E-5 5 36
28 M19358 Signaling of Hepatocyte Growth Factor Receptor MSigDB C2 BIOCARTA (v6.0) 2.364E-8 4.588E-7 3.170E-6 1.328E-5 5 37
29 1270231 Cell-Cell communication BioSystems: REACTOME 2.368E-8 4.588E-7 3.170E-6 1.331E-5 7 134
30 137915 Signaling events regulated by Ret tyrosine kinase BioSystems: Pathway Interaction Database 2.717E-8 5.091E-7 3.517E-6 1.527E-5 5 38
31 M9526 T Cell Signal Transduction MSigDB C2 BIOCARTA (v6.0) 6.537E-8 1.185E-6 8.189E-6 3.674E-5 5 45
32 M19784 T Cell Receptor Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 8.180E-8 1.437E-6 9.926E-6 4.597E-5 5 47
33 M16355 Ras-Independent pathway in NK cell-mediated cytotoxicity MSigDB C2 BIOCARTA (v6.0) 1.292E-7 2.200E-6 1.520E-5 7.261E-5 4 20
34 1269357 GPVI-mediated activation cascade BioSystems: REACTOME 1.667E-7 2.755E-6 1.904E-5 9.367E-5 5 54
35 138049 PDGFR-alpha signaling pathway BioSystems: Pathway Interaction Database 1.944E-7 3.041E-6 2.101E-5 1.093E-4 4 22
36 99051 Chemokine signaling pathway BioSystems: KEGG 1.948E-7 3.041E-6 2.101E-5 1.095E-4 7 182
37 137977 Neurotrophic factor-mediated Trk receptor signaling BioSystems: Pathway Interaction Database 2.006E-7 3.048E-6 2.106E-5 1.128E-4 5 56
38 137970 EGF receptor (ErbB1) signaling pathway BioSystems: Pathway Interaction Database 3.345E-7 4.947E-6 3.418E-5 1.880E-4 4 25
39 1269507 Signaling by Rho GTPases BioSystems: REACTOME 4.826E-7 6.954E-6 4.805E-5 2.712E-4 9 430
40 83082 Fc epsilon RI signaling pathway BioSystems: KEGG 5.366E-7 7.540E-6 5.210E-5 3.016E-4 5 68
41 137980 Reelin signaling pathway BioSystems: Pathway Interaction Database 6.239E-7 8.543E-6 5.903E-5 3.506E-4 4 29
42 83079 Natural killer cell mediated cytotoxicity BioSystems: KEGG 6.384E-7 8.543E-6 5.903E-5 3.588E-4 6 133
43 1269177 Costimulation by the CD28 family BioSystems: REACTOME 7.668E-7 1.002E-5 6.925E-5 4.309E-4 5 73
44 P00053 T cell activation PantherDB 9.384E-7 1.199E-5 8.282E-5 5.274E-4 5 76
45 1269487 Signaling by SCF-KIT BioSystems: REACTOME 9.863E-7 1.232E-5 8.511E-5 5.543E-4 8 340
46 1270318 Signaling by Robo receptor BioSystems: REACTOME 1.068E-6 1.304E-5 9.013E-5 6.000E-4 4 33
47 1311074 Phospholipase D signaling pathway BioSystems: KEGG 1.105E-6 1.321E-5 9.127E-5 6.208E-4 6 146
48 P00005 Angiogenesis PantherDB 1.294E-6 1.515E-5 1.047E-4 7.273E-4 6 150
49 1269479 Downstream signal transduction BioSystems: REACTOME 1.365E-6 1.566E-5 1.082E-4 7.671E-4 8 355
50 M3494 Thrombin signaling and protease-activated receptors MSigDB C2 BIOCARTA (v6.0) 1.712E-6 1.924E-5 1.329E-4 9.620E-4 4 37
Show 45 more annotations

8: Pubmed [Display Chart] 32 input genes in category / 7907 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 24728074 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. Pubmed 6.026E-29 4.765E-25 4.552E-24 4.765E-25 13 63
2 24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Pubmed 8.513E-27 2.334E-23 2.230E-22 6.731E-23 14 133
3 16273093 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Pubmed 9.342E-27 2.334E-23 2.230E-22 7.387E-23 13 90
4 25402006 In silico prediction of physical protein interactions and characterization of interactome orphans. Pubmed 1.181E-26 2.334E-23 2.230E-22 9.336E-23 14 136
5 20624904 Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. Pubmed 6.909E-26 1.093E-22 1.044E-21 5.463E-22 10 24
6 22974441 SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Pubmed 2.263E-24 2.982E-21 2.849E-20 1.789E-20 10 32
7 18067320 Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications. Pubmed 2.881E-19 3.254E-16 3.109E-15 2.278E-15 8 28
8 25814554 Phospho-tyrosine dependent protein-protein interaction network. Pubmed 6.006E-18 5.936E-15 5.670E-14 4.749E-14 13 410
9 28086240 ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. Pubmed 1.763E-17 1.549E-14 1.480E-13 1.394E-13 6 9
10 20598684 Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. Pubmed 4.406E-17 3.484E-14 3.328E-13 3.484E-13 6 10
11 22745667 Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. Pubmed 1.296E-16 9.318E-14 8.901E-13 1.025E-12 8 56
12 12522270 Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Pubmed 2.877E-16 1.895E-13 1.811E-12 2.275E-12 7 30
13 11741599 Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. Pubmed 1.047E-15 6.368E-13 6.083E-12 8.279E-12 6 15
14 10022833 Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. Pubmed 1.674E-15 9.402E-13 8.981E-12 1.324E-11 6 16
15 15556646 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. Pubmed 1.784E-15 9.402E-13 8.981E-12 1.410E-11 5 6
16 20697350 The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Pubmed 2.113E-15 1.044E-12 9.978E-12 1.671E-11 8 78
17 11133830 The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation. Pubmed 1.663E-14 7.733E-12 7.387E-11 1.315E-10 5 8
18 15696170 Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Pubmed 3.739E-14 1.642E-11 1.569E-10 2.956E-10 5 9
19 8662998 Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. Pubmed 7.473E-14 3.110E-11 2.971E-10 5.909E-10 5 10
20 17474147 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Pubmed 1.103E-13 4.361E-11 4.166E-10 8.722E-10 10 330
21 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 3.536E-13 1.331E-10 1.272E-9 2.796E-9 10 371
22 19414610 Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion. Pubmed 4.057E-13 1.458E-10 1.393E-9 3.208E-9 4 4
23 11114734 The protein tyrosine kinase family of the human genome. Pubmed 5.691E-13 1.957E-10 1.869E-9 4.500E-9 7 83
24 10790433 Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. Pubmed 8.879E-13 2.925E-10 2.795E-9 7.021E-9 5 15
25 11431473 Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. Pubmed 1.291E-12 4.082E-10 3.900E-9 1.021E-8 5 16
26 12147689 Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. Pubmed 2.027E-12 5.527E-10 5.280E-9 1.603E-8 4 5
27 7926767 Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Pubmed 2.027E-12 5.527E-10 5.280E-9 1.603E-8 4 5
28 15388330 Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. Pubmed 2.027E-12 5.527E-10 5.280E-9 1.603E-8 4 5
29 10022120 Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Pubmed 2.027E-12 5.527E-10 5.280E-9 1.603E-8 4 5
30 19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. Pubmed 3.257E-12 8.584E-10 8.200E-9 2.575E-8 6 50
31 11418612 T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein. Pubmed 6.078E-12 1.550E-9 1.481E-8 4.806E-8 4 6
32 12186560 Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Pubmed 1.417E-11 3.296E-9 3.149E-8 1.121E-7 4 7
33 1383690 A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. Pubmed 1.417E-11 3.296E-9 3.149E-8 1.121E-7 4 7
34 10829062 The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. Pubmed 1.417E-11 3.296E-9 3.149E-8 1.121E-7 4 7
35 8635998 c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
36 9489702 LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
37 16289966 Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
38 12359715 Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
39 11368773 Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
40 22267732 Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
41 7537265 Functional interaction between c-Src and its mitotic target, Sam 68. Pubmed 2.833E-11 5.463E-9 5.219E-8 2.240E-7 4 8
42 10571082 The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains. Pubmed 5.096E-11 9.523E-9 9.097E-8 4.030E-7 4 9
43 17192257 Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Pubmed 5.179E-11 9.523E-9 9.097E-8 4.095E-7 6 78
44 8621719 p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. Pubmed 1.999E-10 3.592E-8 3.431E-7 1.580E-6 4 12
45 23793062 The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Pubmed 3.549E-10 6.236E-8 5.957E-7 2.806E-6 5 45
46 12620186 Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Pubmed 5.342E-10 7.680E-8 7.337E-7 4.224E-6 3 3
47 11850418 Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. Pubmed 5.342E-10 7.680E-8 7.337E-7 4.224E-6 3 3
48 18268094 Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors. Pubmed 5.342E-10 7.680E-8 7.337E-7 4.224E-6 3 3
49 17373694 Overexpression of protease-activated receptors-1,-2, and-4 (PAR-1, -2, and -4) in prostate cancer. Pubmed 5.342E-10 7.680E-8 7.337E-7 4.224E-6 3 3
50 10087612 Waltzing with WASP. Pubmed 5.342E-10 7.680E-8 7.337E-7 4.224E-6 3 3
Show 45 more annotations

9: Interaction [Display Chart] 32 input genes in category / 1702 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DOK1 DOK1 interactions 3.223E-28 5.485E-25 4.397E-24 5.485E-25 14 53
2 int:CBL CBL interactions 3.874E-23 3.297E-20 2.643E-19 6.593E-20 17 271
3 int:CBLB CBLB interactions 3.824E-20 2.169E-17 1.739E-16 6.508E-17 12 92
4 int:PIK3R1 PIK3R1 interactions 5.641E-20 2.400E-17 1.924E-16 9.601E-17 15 251
5 int:LCP2 LCP2 interactions 2.380E-19 8.103E-17 6.496E-16 4.051E-16 10 45
6 int:NCK1 NCK1 interactions 1.196E-18 3.394E-16 2.721E-15 2.036E-15 12 121
7 int:SRC SRC interactions 1.806E-18 4.391E-16 3.521E-15 3.074E-15 16 405
8 int:SOS1 SOS1 interactions 4.491E-17 8.636E-15 6.923E-14 7.644E-14 10 73
9 int:ABL1 ABL1 interactions 4.742E-17 8.636E-15 6.923E-14 8.072E-14 13 226
10 int:LAT LAT interactions 5.074E-17 8.636E-15 6.923E-14 8.636E-14 9 45
11 int:ZAP70 ZAP70 interactions 5.978E-17 9.003E-15 7.218E-14 1.018E-13 10 75
12 int:KIT KIT interactions 6.876E-17 9.003E-15 7.218E-14 1.170E-13 10 76
13 int:WASF1 WASF1 interactions 6.876E-17 9.003E-15 7.218E-14 1.170E-13 10 76
14 int:WAS WAS interactions 9.044E-17 1.100E-14 8.815E-14 1.539E-13 10 78
15 int:SOCS1 SOCS1 interactions 1.531E-16 1.737E-14 1.392E-13 2.605E-13 10 82
16 int:ERBB2 ERBB2 interactions 1.688E-16 1.796E-14 1.440E-13 2.874E-13 13 249
17 int:SHB SHB interactions 1.843E-16 1.845E-14 1.479E-13 3.136E-13 8 29
18 int:KHDRBS1 KHDRBS1 interactions 3.970E-16 3.754E-14 3.009E-13 6.756E-13 12 194
19 int:ERBB3 ERBB3 interactions 4.226E-16 3.785E-14 3.035E-13 7.192E-13 12 195
20 int:SYK SYK interactions 4.834E-16 4.114E-14 3.298E-13 8.228E-13 11 138
21 int:SHC1 SHC1 interactions 7.102E-16 5.756E-14 4.615E-13 1.209E-12 13 278
22 int:WIPF1 WIPF1 interactions 7.748E-16 5.994E-14 4.805E-13 1.319E-12 8 34
23 int:WASL WASL interactions 3.155E-15 2.310E-13 1.852E-12 5.369E-12 9 69
24 int:BLNK BLNK interactions 3.258E-15 2.310E-13 1.852E-12 5.545E-12 8 40
25 int:PLCG1 PLCG1 interactions 4.387E-15 2.987E-13 2.395E-12 7.467E-12 11 168
26 int:PXN PXN interactions 1.209E-14 7.912E-13 6.343E-12 2.057E-11 10 125
27 int:BCAR1 BCAR1 interactions 2.014E-14 1.269E-12 1.018E-11 3.427E-11 9 84
28 int:ABI1 ABI1 interactions 2.249E-14 1.367E-12 1.096E-11 3.828E-11 9 85
29 int:DNM2 DNM2 interactions 3.573E-14 2.097E-12 1.681E-11 6.080E-11 10 139
30 int:FASLG FASLG interactions 6.344E-14 3.599E-12 2.886E-11 1.080E-10 9 95
31 int:PDGFRB PDGFRB interactions 2.678E-13 1.470E-11 1.179E-10 4.557E-10 9 111
32 int:VAV1 VAV1 interactions 2.908E-13 1.547E-11 1.240E-10 4.950E-10 9 112
33 int:INPP5D INPP5D interactions 4.342E-13 2.239E-11 1.795E-10 7.389E-10 8 71
34 int:ABL2 ABL2 interactions 1.141E-12 5.711E-11 4.579E-10 1.942E-9 7 44
35 int:NEDD9 NEDD9 interactions 3.417E-12 1.646E-10 1.320E-9 5.816E-9 7 51
36 int:GAB3 GAB3 interactions 3.482E-12 1.646E-10 1.320E-9 5.926E-9 5 10
37 int:WASF2 WASF2 interactions 4.538E-12 2.088E-10 1.674E-9 7.724E-9 7 53
38 int:PTK2B PTK2B interactions 5.250E-12 2.351E-10 1.885E-9 8.935E-9 8 96
39 int:CD19 CD19 interactions 6.116E-12 2.669E-10 2.140E-9 1.041E-8 6 27
40 int:BCR BCR interactions 7.332E-12 3.120E-10 2.501E-9 1.248E-8 8 100
41 int:ARHGAP32 ARHGAP32 interactions 8.798E-12 3.652E-10 2.928E-9 1.497E-8 7 58
42 int:PTK2 PTK2 interactions 9.417E-12 3.816E-10 3.059E-9 1.603E-8 9 164
43 int:FYN FYN interactions 1.514E-11 5.994E-10 4.805E-9 2.577E-8 10 254
44 int:FGFR1 FGFR1 interactions 1.971E-11 7.624E-10 6.112E-9 3.355E-8 9 178
45 int:CRK CRK interactions 5.595E-11 2.081E-9 1.669E-8 9.522E-8 10 290
46 int:MAP4K1 MAP4K1 interactions 5.625E-11 2.081E-9 1.669E-8 9.574E-8 6 38
47 int:KDR KDR interactions 7.541E-11 2.731E-9 2.189E-8 1.284E-7 7 78
48 int:LCK LCK interactions 1.329E-10 4.712E-9 3.778E-8 2.262E-7 8 143
49 int:GAB2 GAB2 interactions 1.397E-10 4.755E-9 3.812E-8 2.377E-7 7 85
50 int:RASA1 RASA1 interactions 1.397E-10 4.755E-9 3.812E-8 2.377E-7 7 85
Show 45 more annotations

10: Cytoband [Display Chart] 32 input genes in category / 31 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q13 5q13 1.886E-4 5.845E-3 2.354E-2 5.845E-3 2 22
2 15q24-q25.1 15q24-q25.1 9.232E-4 1.431E-2
5.763E-2
 2.862E-2 1 1
3 15q15.1-q21.1 15q15.1-q21.1 1.846E-3 1.907E-2
7.681E-2
5.721E-2
 1 2
4 17q24-q25 17q24-q25 3.688E-3 2.287E-2
9.208E-2
1.143E-1
 1 4
5 5q31-q32 5q31-q32 3.688E-3 2.287E-2
9.208E-2
1.143E-1
 1 4
6 5q13.1 5q13.1 5.527E-3 2.853E-2
1.149E-1
1.713E-1
 1 6
7 7p12.2 7p12.2 6.445E-3 2.853E-2
1.149E-1
1.998E-1
 1 7
8 10p11.2 10p11.2 7.363E-3 2.853E-2
1.149E-1
2.282E-1
 1 8
9 2q12 2q12 1.102E-2 3.797E-2
1.529E-1
3.418E-1
 1 12
10 7q31.3 7q31.3 1.376E-2 4.054E-2
1.633E-1
4.266E-1
 1 15
11 9q34.1 9q34.1 1.740E-2 4.054E-2
1.633E-1
5.394E-1
 1 19
12 9q22 9q22 1.740E-2 4.054E-2
1.633E-1
5.394E-1
 1 19
13 9p13.2 9p13.2 1.740E-2 4.054E-2
1.633E-1
5.394E-1
 1 19
14 8p21.1 8p21.1 1.831E-2 4.054E-2
1.633E-1
5.676E-1
 1 20
15 2q24.2 2q24.2 2.103E-2 4.249E-2
1.711E-1
6.518E-1
 1 23
16 3q21 3q21 2.193E-2 4.249E-2
1.711E-1
6.799E-1
 1 24
17 2q33.3 2q33.3 2.824E-2 4.900E-2
1.973E-1
8.754E-1
 1 31
18 12p12.3 12p12.3 2.914E-2 4.900E-2
1.973E-1
9.033E-1
 1 32
19 1q25.2 1q25.2 3.003E-2 4.900E-2
1.973E-1
9.311E-1
 1 33
20 5q13.3 5q13.3 3.183E-2 4.933E-2
1.987E-1
9.866E-1
 1 35
Show 15 more annotations

11: Transcription Factor Binding Site [Display Chart] 27 input genes in category / 192 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 27 input genes in category / 11 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 741 SH2 domain containing genenames.org 2.276E-35 2.503E-34 7.559E-34 2.503E-34 18 101
2 219 F2R receptors genenames.org 1.165E-8 6.406E-8 1.934E-7 1.281E-7 3 4
3 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 1.168E-5 4.284E-5 1.294E-4 1.285E-4 5 206
4 1288 F-BAR domain containing genenames.org 5.263E-4 1.447E-3 4.371E-3 5.790E-3 2 23
5 870 Minor histocompatibility antigens|FERM domain containing genenames.org 2.585E-3 5.688E-3 1.718E-2 2.844E-2 2 51
6 830 Pleckstrin homology domain containing|C2 and RasGAP domain containing genenames.org 1.474E-2 2.703E-2
8.163E-2
1.622E-1
 1 10
7 14 Wiskott-Aldrich Syndrome protein family genenames.org 2.349E-2 3.691E-2
1.115E-1
2.584E-1
 1 16
8 654 Mitogen-activated protein kinase kinase kinases genenames.org 3.504E-2 4.818E-2
1.455E-1
3.854E-1
 1 24
Show 3 more annotations

13: Coexpression [Display Chart] 32 input genes in category / 3467 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5893 Genes important for mitotic spindle assembly. MSigDB H: Hallmark Gene Sets (v6.0) 9.098E-9 3.154E-5 2.753E-4 3.154E-5 7 200
2 20460173-ImmPortNaturalKillerCellCytotoxicity Human Immune Kong10 135genes ImmPort NaturalKillerCellCytotoxicity GeneSigDB 1.867E-8 3.236E-5 2.825E-4 6.473E-5 6 126
3 19129520-TableS27 Human StemCell Mullighan09 39genes GeneSigDB 2.152E-7 2.487E-4 2.170E-3 7.460E-4 4 38
4 20564080-Table3 Human Leukemia Messina10 53genes GeneSigDB 5.617E-7 4.031E-4 3.518E-3 1.947E-3 4 48
5 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 5.813E-7 4.031E-4 3.518E-3 2.015E-3 7 368
6 M2511 Genes up-regulated in C3H10T1/2 cells (mesenchyme multipotent cells) upon their differentiation to brown adipocytes in response to BMP7 [GeneID=655]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.657E-7 5.002E-4 4.366E-3 3.001E-3 3 14
7 17312329-SuppTable4 Human Leukemia Juric07 106genes GeneSigDB 2.045E-6 1.013E-3 8.839E-3 7.088E-3 4 66
8 M5434 Genes up-regulated in comparison of mast cells versus B cells. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 3.314E-3 2.892E-2 2.651E-2 5 200
9 M1489 Genes required for CTNNB1 [GeneID=1499] activity in DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.275E-5 4.842E-3 4.227E-2 4.419E-2 3 33
10 18794102-TableS2 Human Breast Yang08 47genes GeneSigDB 1.397E-5 4.842E-3 4.227E-2 4.842E-2 3 34
11 15705876-TableS2 Human Leukemia Passioura05 37genes GeneSigDB 1.663E-5 5.243E-3 4.576E-2
5.767E-2
 3 36
12 M3782 Genes down-regulated in ST1 cells (adult T-cell leukemia, ATL) after knockdown of FRA2 [GeneID=2355] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.856E-5 8.252E-3
7.203E-2
9.902E-2
 3 43
13 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.585E-5 1.223E-2
1.067E-1
1.590E-1
 6 483
14 M1741 Genes whose promoters are bound by FOXP3 [GeneID=50943] based an a ChIP-chip analysis. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.023E-5 1.244E-2
1.086E-1
1.741E-1
 6 491
15 M2351 Genes down-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130, 2313] compared to normal hematopoetic progenitors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.377E-5 1.433E-2
1.251E-1
2.558E-1
 5 321
16 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.596E-5 1.433E-2
1.251E-1
2.634E-1
 5 323
17 18794102-TableS1 Human Breast Yang08 840genes GeneSigDB 9.538E-5 1.433E-2
1.251E-1
3.307E-1
 5 339
18 M5354 Genes required for proliferation of DLD-1 cell (colon cancer with APC [GeneID=324] deletions), based on shRNA screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.637E-5 1.433E-2
1.251E-1
3.341E-1
 4 175
19 M2024 Genes up-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.903E-5 1.433E-2
1.251E-1
3.433E-1
 3 65
20 M16718 The lung adenocarcinoma TSP (tumor sequencing project) genes with significantly higher frequencies of nonsense, splice site, and frame-shift mutations. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.213E-4 1.433E-2
1.251E-1
4.204E-1
 2 12
21 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 1.331E-4 1.433E-2
1.251E-1
4.615E-1
 5 364
22 M7463 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus TGF beta. MSigDB C7: Immunologic Signatures (v6.0) 1.521E-4 1.433E-2
1.251E-1
5.273E-1
 4 197
23 M2155 Genes up-regulated during pubertal mammary gland development between week 6 and 7. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.521E-4 1.433E-2
1.251E-1
5.273E-1
 4 197
24 M4676 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] effector memory T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.551E-4 1.433E-2
1.251E-1
5.376E-1
 4 198
25 M5205 Genes up-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 1.581E-4 1.433E-2
1.251E-1
5.481E-1
 4 199
26 M3460 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 1.581E-4 1.433E-2
1.251E-1
5.481E-1
 4 199
27 M5176 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus macrophages exposed to L. donovani. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
28 M5950 Genes up-regulated during transplant rejection. MSigDB H: Hallmark Gene Sets (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
29 M9447 Genes up-regulated in splenocytes: control versus infected with Baki-1 MuLV virus. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
30 M9540 Genes up-regulated in bone marrow-derived mast cells treated with IL3 [GeneID=3562]: control versus IL33 [GeneID=90865]. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
31 M7480 Genes down-regulated in periperal blood monocytes (PBMC): tolerant kidney transplants versus healthy controls. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
32 M5915 Genes encoding components of apical junction complex. MSigDB H: Hallmark Gene Sets (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
33 M3350 Genes down-regulated in comparison of dendritic cells (DC) before and 16 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
34 M7751 Genes down-regulated in macrophages 12h after M. bovis BCG infection: wildtype versus MYD88 [GeneID=4615] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
35 M8551 Genes up-regulated in CD8 T cells: KLRB1 high [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
36 M3978 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
37 M9653 Genes down-regulated in CD4 [GeneID=920] T helper cells (52h): Th0 versus Th17 treated with TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
38 M5596 Genes up-regulated in comparison of NK cells versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
39 M8542 Genes down-regulated in CD8 T cells: KLRB1 high [GeneID=3820] versus KLRB1- [GeneID=3820]. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 1.433E-2
1.251E-1
5.588E-1
 4 200
40 M4385 Genes up-regulated in NB4 cells (acute promyelocytic leukemia, APL) by tretinoin [PubChem=444795] alone. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.197E-4 1.858E-2
1.622E-1
7.617E-1
 2 16
41 M12692 Genes in the green cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.197E-4 1.858E-2
1.622E-1
7.617E-1
 2 16
42 11973655-Table4 Human Viral Delpuech02 21genes GeneSigDB 2.796E-4 2.203E-2
1.923E-1
9.695E-1
 2 18
43 M5304 Amplification hot spot 8: colocolized fragile sites and cancer genes in the 9q11-34 region. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.796E-4 2.203E-2
1.923E-1
9.695E-1
 2 18
44 M1587 Genes in cluster 4: immediate down-regulation in HFW cells (fibroblast) by sodium arsenite [PubChem=26435]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.796E-4 2.203E-2
1.923E-1
9.695E-1
 2 18
45 19605494-TableS3 Mouse Skin Driskell09 685genes GeneSigDB 3.106E-4 2.393E-2
2.089E-1
1.000E0
 5 437
46 M13095 Genes up-regulated specifically in human thymus. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.467E-4 2.540E-2
2.217E-1
1.000E0
 2 20
47 M15626 Genes up-regulated during prostate cancer progression in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.467E-4 2.540E-2
2.217E-1
1.000E0
 2 20
48 17312329-SuppTable2 Human Leukemia Juric07 617genes GeneSigDB 3.517E-4 2.540E-2
2.217E-1
1.000E0
 5 449
49 M9399 Top up-regulated genes from principal component 1 (PCA1) which captures variation between normal plasma cells and tumors arising from aberrant expression of BCL2L1 and MYC [GeneID=598;4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.653E-4 2.584E-2
2.256E-1
1.000E0
 3 101
50 M8646 Genes down-regulated both in group C and D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.887E-4 2.695E-2
2.353E-1
1.000E0
 4 252
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 32 input genes in category / 2530 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM538395 500 alpha beta T cells, T.8Mem.LN, CD8 TCRb CD44high CD122high, Lymph Node, avg-3 Immgen.org, GSE15907 4.036E-7 1.021E-3 8.591E-3 1.021E-3 7 329
2 GSM538392 500 alpha beta T cells, T.8Eff.Sp.OT1.d8.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.197E-6 1.045E-3 8.793E-3 3.030E-3 7 387
3 GSM605790 500 gamma delta T cells, Tgd.vg2+.Sp.TCRbko, TCRd+ Vg2+ CD44-, Spleen, avg-3 Immgen.org, GSE15907 1.239E-6 1.045E-3 8.793E-3 3.135E-3 7 389
4 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-CCL5, IL32, NKG7 Top 200 Genes 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-CCL5, IL32, NKG7 Top 200 Genes 1.071E-5 4.461E-3 3.753E-2 2.711E-2 6 352
5 GSM538371 500 alpha beta T cells, T.4Mem44h62l.Sp, CD4 TCRb CD44hi CD62Llo, Spleen, avg-3 Immgen.org, GSE15907 1.198E-5 4.461E-3 3.753E-2 3.031E-2 6 359
6 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-LYZ, S100A8, S100A9 Top 200 Genes 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-LYZ, S100A8, S100A9 Top 200 Genes 1.379E-5 4.461E-3 3.753E-2 3.488E-2 6 368
7 10X Human 8K PBMC T cell Subtype T cell-CCL5, NKG7, CST7 Top 200 Genes 10X Human 8K PBMC T cell Subtype T cell-CCL5, NKG7, CST7 Top 200 Genes 1.444E-5 4.461E-3 3.753E-2 3.652E-2 6 371
8 GSM538389 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.511E-5 4.461E-3 3.753E-2 3.822E-2 6 374
9 GSM538403 500 alpha beta T cells, T.8Mem.Sp.OT1.d45.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.728E-5 4.461E-3 3.753E-2 4.372E-2 6 383
10 GSM538291 500 NK cells, NK.b2m-.Sp, NK1.1+ TCRb-, Spleen, avg-3 Immgen.org, GSE15907 1.914E-5 4.461E-3 3.753E-2 4.842E-2 6 390
11 GSM476678 500 gamma delta T cells, Tgd.vg2+.act.Sp, TCRd+ Vg2+ CD44+, Spleen, avg-3 Immgen.org, GSE15907 2.056E-5 4.461E-3 3.753E-2
5.203E-2
 6 395
12 Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Myeloid Overall Top 500 Genes 2.116E-5 4.461E-3 3.753E-2
5.353E-2
 6 397
13 GSM605796 500 gamma delta T cells, Tgd.vg2-.Sp.TCRbko, TCRd+ Vg2- CD44-, Spleen, avg-3 Immgen.org, GSE15907 2.367E-5 4.520E-3 3.803E-2
5.989E-2
 6 405
14 GSM538315 500 NK cells, NK.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 2.501E-5 4.520E-3 3.803E-2
6.329E-2
 6 409
15 Lung Development Lungmap - Mouse FluidigmC1 Pericyte Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Pericyte Overall Top 500 Genes 4.595E-5 7.750E-3
6.520E-2
1.163E-1
 6 456
16 GSM538398 500 alpha beta T cells, T.8Mem.Sp, 4- 8+ 25- 44hi 122hi, Spleen, avg-3 Immgen.org, GSE15907 7.382E-5 1.088E-2
9.158E-2
1.868E-1
 5 303
17 Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D Top 200 Genes 9.269E-5 1.088E-2
9.158E-2
2.345E-1
 5 318
18 Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D E18.5 Top 200 Genes 9.269E-5 1.088E-2
9.158E-2
2.345E-1
 5 318
19 GSM605756 500 alpha beta T cells, T.4.Pa.BDC, 4+ 8- BDC+, Pancreas, avg-2 Immgen.org, GSE15907 1.072E-4 1.088E-2
9.158E-2
2.712E-1
 5 328
20 GSM538329 500 alpha beta T cells, NKT.4-.Sp, TCRbeta+ aGalCer tet+ CD4-, Spleen, avg-3 Immgen.org, GSE15907 1.135E-4 1.088E-2
9.158E-2
2.871E-1
 5 332
21 GSM538406 500 alpha beta T cells, T.8Nve.LN, 4- 8+ 25- 62Lhi 44lo, Lymph Node, avg-3 Immgen.org, GSE15907 1.167E-4 1.088E-2
9.158E-2
2.953E-1
 5 334
22 GSM538374 500 alpha beta T cells, T.4Nve.LN, 4+ 8- 25- 62Lhi 44lo, Lymph Node, avg-3 Immgen.org, GSE15907 1.200E-4 1.088E-2
9.158E-2
3.037E-1
 5 336
23 GSM538413 500 alpha beta T cells, T.8Nve.PP, TCRb+ CD8+ CD44low CD62L high, Peyer's Patch, avg-1 Immgen.org, GSE15907 1.200E-4 1.088E-2
9.158E-2
3.037E-1
 5 336
24 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-CCL5, CMC1, GZMH Top 200 Genes 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-CCL5, CMC1, GZMH Top 200 Genes 1.217E-4 1.088E-2
9.158E-2
3.079E-1
 5 337
25 GSM403987 500 CD positive, CD4 Test DB, 4+8-B220-, Spleen, avg-1 Immgen.org, GSE15907 1.234E-4 1.088E-2
9.158E-2
3.122E-1
 5 338
26 GSM605763 500 alpha beta T cells, T.4.TI.B16, 4+ 8- TCR+ 45+, B16 Melanoma Tumor, avg-3 Immgen.org, GSE15907 1.234E-4 1.088E-2
9.158E-2
3.122E-1
 5 338
27 GSM538382 500 alpha beta T cells, T.4Nve.Sp, 4+ 8- 25- 62Lhi 44lo, Spleen, avg-4 Immgen.org, GSE15907 1.251E-4 1.088E-2
9.158E-2
3.166E-1
 5 339
28 GSM538365 500 alpha beta T cells, T.4Mem.Sp, 4+ 8- 25- 44hi 122lo, Spleen, avg-3 Immgen.org, GSE15907 1.322E-4 1.088E-2
9.158E-2
3.344E-1
 5 343
29 GSM538362 500 alpha beta T cells, T.4Mem.LN, TCRb CD44high CD122lo CD4, Lymph Node, avg-3 Immgen.org, GSE15907 1.414E-4 1.088E-2
9.158E-2
3.578E-1
 5 348
30 10X Human 8K PBMC T cell Subtype T cell-MALAT1, CD3D, TRAC Top 200 Genes 10X Human 8K PBMC T cell Subtype T cell-MALAT1, CD3D, TRAC Top 200 Genes 1.453E-4 1.088E-2
9.158E-2
3.675E-1
 5 350
31 GSM538325 500 alpha beta T cells, NKT.4-.Lv, CD45 TCRb aGalCer-loaded CD1d tet, Liver, avg-4 Immgen.org, GSE15907 1.472E-4 1.088E-2
9.158E-2
3.724E-1
 5 351
32 GSM538318 500 alpha beta T cells, NKT.4+.Lv, CD45 TCRb aGalCer-loaded CD1d tet CD4, Liver, avg-4 Immgen.org, GSE15907 1.472E-4 1.088E-2
9.158E-2
3.724E-1
 5 351
33 10X Human 8K PBMC CD8 T cells Overall Top 200 Genes 10X Human 8K PBMC CD8 T cells Overall Top 200 Genes 1.492E-4 1.088E-2
9.158E-2
3.774E-1
 4 185
34 GSM538415 500 alpha beta T cells, T.8Nve.Sp, 4- 8+ 25- 62Lhi 44lo, Spleen, avg-3 Immgen.org, GSE15907 1.532E-4 1.088E-2
9.158E-2
3.875E-1
 5 354
35 GSM403986 500 CD positive, CD4 Test NA, 4+8-B220-, Spleen, avg-1 Immgen.org, GSE15907 1.593E-4 1.088E-2
9.158E-2
4.030E-1
 5 357
36 10X Human 8K PBMC CD8 T cells (CCL5, NKG7, GZMK) Subtype CD8 T cells (CCL5, NKG7, GZMK)-CD8 T cells subclass-0 (CCR7, LEF1, RP11-291B21.2) Top 200 Genes 10X Human 8K PBMC CD8 T cells (CCL5, NKG7, GZMK) Subtype CD8 T cells (CCL5, NKG7, GZMK)-CD8 T cells subclass-0 (CCR7, LEF1, RP11-291B21.2) Top 200 Genes 1.593E-4 1.088E-2
9.158E-2
4.030E-1
 5 357
37 GSM404000 500 CD positive, CD4 Test JS, 4+8-B220-, Spleen, avg-3 Immgen.org, GSE15907 1.635E-4 1.088E-2
9.158E-2
4.137E-1
 5 359
38 GSM538385 500 alpha beta T cells, T.8Eff.Sp.OT1.d15.VSVOva, CD8+ CD45.1+, Spleen, avg-2 Immgen.org, GSE15907 1.678E-4 1.088E-2
9.158E-2
4.245E-1
 5 361
39 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-KLRB1, TRGC1, TRDC Top 200 Genes 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-KLRB1, TRGC1, TRDC Top 200 Genes 1.678E-4 1.088E-2
9.158E-2
4.245E-1
 5 361
40 GSM605766 500 alpha beta T cells, T.4FP3-.Sp, 4+ 8- GFP- 44lo, Spleen, avg-3 Immgen.org, GSE15907 1.744E-4 1.090E-2
9.169E-2
4.412E-1
 5 364
41 GSM605904 500 alpha beta T cells, T.8Mem.Sp.OT1.d100.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.766E-4 1.090E-2
9.169E-2
4.468E-1
 5 365
42 GSM538401 500 alpha beta T cells, T.8Mem.Sp.OT1.d106.VSVOva, CD8+ CD45.1+, Spleen, avg-2 Immgen.org, GSE15907 1.812E-4 1.091E-2
9.181E-2
4.583E-1
 5 367
43 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-KLRB1, NKG7, CCL5 Top 200 Genes 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-KLRB1, NKG7, CCL5 Top 200 Genes 1.881E-4 1.107E-2
9.314E-2
4.760E-1
 5 370
44 GSM538288 500 NK cells, NK.49CI-.Sp, NK1.1+ CD3- Ly49C/I-, Spleen, avg-3 Immgen.org, GSE15907 1.929E-4 1.109E-2
9.333E-2
4.881E-1
 5 372
45 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-TRDC, CCL5, TRGC1 Top 200 Genes 10X Human 8K PBMC CD8 T cells Subtype CD8 T cells-TRDC, CCL5, TRGC1 Top 200 Genes 1.978E-4 1.112E-2
9.355E-2
5.004E-1
 5 374
46 GSM476681 500 gamma delta T cells, Tgd.vg2-.act.Sp, TCRd+ Vg2- CD44+, Spleen, avg-3 Immgen.org, GSE15907 2.052E-4 1.129E-2
9.497E-2
5.193E-1
 5 377
47 GSM476684 500 gamma delta T cells, Tgd.vg2-.Sp, TCRd+ Vg2- CD44-, Spleen, avg-3 Immgen.org, GSE15907 2.182E-4 1.164E-2
9.792E-2
5.520E-1
 5 382
48 GSM605907 500 alpha beta T cells, T.8Mem.Sp.OT1.d45.LisOva, CD8+ CD45.1+, Spleen, avg-2 Immgen.org, GSE15907 2.208E-4 1.164E-2
9.792E-2
5.587E-1
 5 383
49 GSM538285 500 NK cells, NK.49CI+.Sp, NK1.1+ CD3- Ly49C/I+, Spleen, avg-3 Immgen.org, GSE15907 2.262E-4 1.168E-2
9.827E-2
5.723E-1
 5 385
50 GSM403995 500 CD positive, CD4 Control, 4+ 8- B220-, Spleen, avg-4 Immgen.org, GSE15907 2.467E-4 1.249E-2
1.050E-1
6.243E-1
 4 211
Show 45 more annotations

15: Computational [Display Chart] 27 input genes in category / 175 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M18786 MODULE 248 Genes in the cancer module 248. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.515E-7 1.665E-4 9.566E-4 1.665E-4 6 129

16: MicroRNA [Display Chart] 32 input genes in category / 1170 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 4.248E-7 4.970E-4 3.798E-3 4.970E-4 5 343
2 hsa-miR-4749-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.081E-6 2.059E-3 1.574E-2 8.284E-3 3 83
3 hsa-miR-455-3p.1:TargetScan hsa-miR-455-3p.1 TargetScan 8.036E-6 2.059E-3 1.574E-2 9.402E-3 4 287
4 hsa-miR-4706:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.736E-6 2.059E-3 1.574E-2 1.022E-2 3 89
5 hsa-miR-6742-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.020E-5 2.059E-3 1.574E-2 1.194E-2 4 305
6 hsa-miR-548ah-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.217E-5 2.059E-3 1.574E-2 1.424E-2 4 319
7 hsa-miR-3609:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.232E-5 2.059E-3 1.574E-2 1.441E-2 4 320
8 hsa-miR-31-5p:TargetScan hsa-miR-31-5p TargetScan 1.491E-5 2.181E-3 1.667E-2 1.745E-2 4 336
9 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 2.314E-5 2.303E-3 1.760E-2 2.708E-2 4 376
10 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 2.314E-5 2.303E-3 1.760E-2 2.708E-2 4 376
11 hsa-miR-6787-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.535E-5 2.303E-3 1.760E-2 2.966E-2 3 127
12 hsa-miR-623:PITA hsa-miR-623:PITA TOP PITA 2.656E-5 2.303E-3 1.760E-2 3.108E-2 3 129
13 hsa-miR-1913:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.718E-5 2.303E-3 1.760E-2 3.180E-2 3 130
14 hsa-miR-1908-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.042E-5 2.303E-3 1.760E-2 3.559E-2 3 135
15 hsa-miR-8073:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.248E-5 2.303E-3 1.760E-2 3.800E-2 3 138
16 hsa-miR-1237-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.687E-5 2.303E-3 1.760E-2 4.314E-2 3 144
17 hsa-miR-221-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.687E-5 2.303E-3 1.760E-2 4.314E-2 3 144
18 hsa-miR-663a:Functional MTI Functional MTI miRTarbase 3.687E-5 2.303E-3 1.760E-2 4.314E-2 3 144
19 hsa-miR-525-3p:mirSVR lowEffct hsa-miR-525-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.901E-5 2.303E-3 1.760E-2 4.564E-2 4 430
20 hsa-miR-6838-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.936E-5 2.303E-3 1.760E-2 4.605E-2 4 431
21 hsa-miR-939-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.227E-5 2.308E-3 1.764E-2 4.946E-2 4 439
22 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 4.340E-5 2.308E-3 1.764E-2
5.078E-2
 4 442
23 hsa-miR-497-5p:Functional MTI Functional MTI miRTarbase 5.066E-5 2.523E-3 1.929E-2
5.927E-2
 4 460
24 hsa-miR-1248:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.330E-5 2.523E-3 1.929E-2
6.237E-2
 3 163
25 hsa-miR-424-5p:Functional MTI Functional MTI miRTarbase 5.551E-5 2.523E-3 1.929E-2
6.495E-2
 4 471
26 hsa-miR-1204:PITA hsa-miR-1204:PITA TOP PITA 5.666E-5 2.523E-3 1.929E-2
6.630E-2
 2 25
27 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 5.925E-5 2.523E-3 1.929E-2
6.932E-2
 4 479
28 hsa-miR-5692c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.470E-5 2.523E-3 1.929E-2
7.570E-2
 3 174
29 hsa-miR-3665:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.470E-5 2.523E-3 1.929E-2
7.570E-2
 3 174
30 hsa-miR-5692b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.470E-5 2.523E-3 1.929E-2
7.570E-2
 3 174
31 hsa-miR-3178:mirSVR lowEffct hsa-miR-3178:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.921E-5 2.612E-3 1.996E-2
8.098E-2
 3 178
32 hsa-miR-6868-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.884E-5 2.883E-3 2.203E-2
9.224E-2
 3 186
33 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 1.006E-4 3.568E-3 2.727E-2
1.177E-1
 3 202
34 hsa-miR-335-5p:TargetScan hsa-miR-335-5p TargetScan 1.210E-4 4.163E-3 3.181E-2
1.415E-1
 3 215
35 hsa-miR-1343-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.347E-4 4.379E-3 3.346E-2
1.576E-1
 3 223
36 hsa-miR-6783-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.347E-4 4.379E-3 3.346E-2
1.576E-1
 3 223
37 hsa-miR-6852-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.438E-4 4.486E-3 3.428E-2
1.683E-1
 3 228
38 hsa-miR-31:PITA hsa-miR-31:PITA TOP PITA 1.457E-4 4.486E-3 3.428E-2
1.705E-1
 3 229
39 hsa-miR-5002-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.542E-4 4.619E-3 3.530E-2
1.804E-1
 2 41
40 hsa-miR-34c-3p:PITA hsa-miR-34c-3p:PITA TOP PITA 1.612E-4 4.619E-3 3.530E-2
1.886E-1
 3 237
41 hsa-miR-218-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.619E-4 4.619E-3 3.530E-2
1.894E-1
 2 42
42 hsa-miR-513a-5p:PITA hsa-miR-513a-5p:PITA TOP PITA 2.116E-4 5.709E-3 4.363E-2
2.475E-1
 3 260
43 hsa-miR-4317:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.117E-4 5.709E-3 4.363E-2
2.477E-1
 2 48
44 hsa-miR-29a-3p:Functional MTI Functional MTI miRTarbase 2.237E-4 5.709E-3 4.363E-2
2.618E-1
 3 265
45 hsa-miR-4799-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.298E-4 5.709E-3 4.363E-2
2.688E-1
 2 50
46 hsa-miR-99b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.298E-4 5.709E-3 4.363E-2
2.688E-1
 2 50
47 hsa-miR-671-3p:mirSVR lowEffct hsa-miR-671-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.363E-4 5.709E-3 4.363E-2
2.765E-1
 3 270
48 hsa-miR-5588-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.391E-4 5.709E-3 4.363E-2
2.797E-1
 2 51
49 hsa-miR-4720-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.391E-4 5.709E-3 4.363E-2
2.797E-1
 2 51
50 hsa-miR-142-3p.1:TargetScan hsa-miR-142-3p.1 TargetScan 2.441E-4 5.712E-3 4.365E-2
2.856E-1
 3 273
Show 45 more annotations

17: Drug [Display Chart] 32 input genes in category / 6878 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000439587 polyproline Stitch 1.509E-20 1.038E-16 9.769E-16 1.038E-16 15 295
2 CID000003591 AC1L1G9T Stitch 2.968E-13 1.021E-9 9.607E-9 2.041E-9 12 433
3 CID005287760 AC1NRA8W Stitch 4.510E-10 8.145E-7 7.667E-6 3.102E-6 5 29
4 ctd:C545373 ponatinib CTD 4.737E-10 8.145E-7 7.667E-6 3.258E-6 6 68
5 CID000030956 AC1L1KMJ Stitch 6.017E-10 8.277E-7 7.791E-6 4.138E-6 10 476
6 CID000005291 imatinib Stitch 5.222E-9 5.987E-6 5.635E-5 3.592E-5 9 430
7 CID005288160 etheno-NAD Stitch 6.339E-9 6.229E-6 5.864E-5 4.360E-5 6 104
8 CID000132900 Pp55 Stitch 7.882E-9 6.776E-6 6.379E-5 5.421E-5 5 50
9 CID000004813 AC1L1J0H Stitch 8.947E-9 6.837E-6 6.436E-5 6.154E-5 7 197
10 CID003062316 dasatinib Stitch 4.414E-8 3.036E-5 2.858E-4 3.036E-4 5 70
11 CID000010157 selva Stitch 6.343E-8 3.966E-5 3.733E-4 4.363E-4 4 28
12 CID000005637 U0126 Stitch 1.065E-7 6.106E-5 5.748E-4 7.327E-4 8 431
13 CID006857406 AC1OAGKB Stitch 2.954E-7 1.365E-4 1.285E-3 2.032E-3 6 198
14 CID000091437 terreic acid Stitch 2.977E-7 1.365E-4 1.285E-3 2.048E-3 3 10
15 DB01254 Dasatinib Drug Bank 2.977E-7 1.365E-4 1.285E-3 2.048E-3 3 10
16 CID000005309 IN1076 Stitch 4.694E-7 1.959E-4 1.844E-3 3.229E-3 5 112
17 CID000445266 AC1L9HP6 Stitch 4.967E-7 1.959E-4 1.844E-3 3.416E-3 4 46
18 CID000002712 chlordiazepoxide Stitch 5.127E-7 1.959E-4 1.844E-3 3.526E-3 5 114
19 CID009549299 EGFR inhibitor Stitch 6.616E-7 2.395E-4 2.255E-3 4.551E-3 5 120
20 CID000003800 NSC613009 Stitch 1.022E-6 3.515E-4 3.309E-3 7.030E-3 5 131
21 CID000004778 phenylarsine oxide Stitch 2.052E-6 6.720E-4 6.326E-3 1.411E-2 6 276
22 CID000007041 2,6-dimethoxyphenol Stitch 2.426E-6 7.584E-4 7.139E-3 1.668E-2 4 68
23 CID000004597 o-nitrophenyl beta-D-fucopyranoside Stitch 3.596E-6 1.075E-3 1.012E-2 2.473E-2 4 75
24 CID000061671 vanadyl Stitch 3.791E-6 1.086E-3 1.023E-2 2.607E-2 6 307
25 CID000627503 link Er Stitch 4.955E-6 1.363E-3 1.283E-2 3.408E-2 3 24
26 CID000000082 5-enolpyruvoylshikimate-3-phosphate Stitch 5.658E-6 1.497E-3 1.409E-2 3.891E-2 4 84
27 CID000643960 PtdIns(3,4)P Stitch 6.508E-6 1.658E-3 1.561E-2 4.476E-2 4 87
28 CID006857413 AC1OAGKW Stitch 6.842E-6 1.681E-3 1.582E-2 4.706E-2 5 193
29 CID005328803 AG213 Stitch 7.124E-6 1.690E-3 1.591E-2 4.900E-2 4 89
30 1181 DN 2-propylpentanoic acid; Down 200; 500uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.559E-6 1.733E-3 1.631E-2
5.199E-2
 5 197
31 CID003034747 C070379 Stitch 8.135E-6 1.805E-3 1.699E-2
5.595E-2
 5 200
32 CID000164073 Pkcs Stitch 1.054E-5 2.266E-3 2.133E-2
7.253E-2
 5 211
33 CID000132707 Sfllrnp Stitch 1.324E-5 2.760E-3 2.598E-2
9.109E-2
 3 33
34 CID003081453 Bradykinin (1-5) Stitch 1.879E-5 3.727E-3 3.508E-2
1.292E-1
 3 37
35 ctd:D013917 Thrombin CTD 1.897E-5 3.727E-3 3.508E-2
1.304E-1
 2 5
36 CID000122124 AC1L3U0V Stitch 2.382E-5 4.552E-3 4.285E-2
1.639E-1
 3 40
37 CID000005305 AC1L1K22 Stitch 2.568E-5 4.750E-3 4.472E-2
1.766E-1
 3 41
38 CID000123631 gefitinib Stitch 2.625E-5 4.750E-3 4.472E-2
1.805E-1
 5 255
39 CID000005262 AC1L1JYL Stitch 2.745E-5 4.751E-3 4.472E-2
1.888E-1
 6 435
40 CID000003300 SA-7 Stitch 2.763E-5 4.751E-3 4.472E-2
1.900E-1
 3 42
41 ctd:D000068877 Imatinib Mesylate CTD 4.375E-5 6.838E-3
6.437E-2
3.009E-1
 4 141
42 CID000058035 AC1L1O6Q Stitch 4.375E-5 6.838E-3
6.437E-2
3.009E-1
 4 141
43 CID000002051 0-to Stitch 4.375E-5 6.838E-3
6.437E-2
3.009E-1
 4 141
44 CID000214797 Ro 31 Stitch 4.375E-5 6.838E-3
6.437E-2
3.009E-1
 4 141
45 CID000643963 PI(3,4,5)P3 Stitch 5.285E-5 7.919E-3
7.455E-2
3.635E-1
 4 148
46 CID000004758 phenoxyethylpenicillin Stitch 5.296E-5 7.919E-3
7.455E-2
3.643E-1
 2 8
47 CID000176870 erlotinib Stitch 6.014E-5 8.802E-3
8.285E-2
4.137E-1
 4 153
48 CID000162656 L-Phe-pro Stitch 6.583E-5 9.433E-3
8.880E-2
4.528E-1
 3 56
49 ctd:C074619 bivalirudin CTD 6.804E-5 9.550E-3
8.990E-2
4.680E-1
 2 9
50 CID000644241 nilotinib Stitch 7.314E-5 1.006E-2
9.471E-2
5.030E-1
 3 58
Show 45 more annotations

18: Disease [Display Chart] 31 input genes in category / 853 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0079774 Peripheral T-Cell Lymphoma DisGeNET Curated 3.107E-6 2.650E-3 1.942E-2 2.650E-3 5 121
2 C0345964 Adenoma of lung DisGeNET BeFree 1.094E-5 4.665E-3 3.418E-2 9.331E-3 3 23
3 C0015967 Fever DisGeNET Curated 9.608E-5 1.959E-2
1.435E-1
8.196E-2
 4 127
4 C0278787 relapsing chronic myelogenous leukemia DisGeNET BeFree 9.846E-5 1.959E-2
1.435E-1
8.399E-2
 2 8
5 C1704272 Benign Prostatic Hyperplasia DisGeNET BeFree 1.148E-4 1.959E-2
1.435E-1
9.794E-2
 6 414
6 C0030297 Pancreatic Neoplasm DisGeNET Curated 1.524E-4 2.166E-2
1.587E-1
1.300E-1
 6 436
7 C0043194 Wiskott-Aldrich Syndrome DisGeNET Curated 2.920E-4 3.472E-2
2.544E-1
2.491E-1
 3 68
8 C0206142 Eosinophilic leukemia DisGeNET BeFree 5.316E-4 3.472E-2
2.544E-1
4.535E-1
 2 18
9 C1332078 Anaplastic large cell lymphoma, ALK negative DisGeNET BeFree 6.586E-4 3.472E-2
2.544E-1
5.618E-1
 2 20
10 C0220668 Congenital contractural arachnodactyly DisGeNET Curated 6.912E-4 3.472E-2
2.544E-1
5.896E-1
 4 213
11 C0206180 Ki-1+ Anaplastic Large Cell Lymphoma DisGeNET Curated 7.410E-4 3.472E-2
2.544E-1
6.321E-1
 4 217
12 C0853879 Invasive carcinoma of breast DisGeNET BeFree 7.531E-4 3.472E-2
2.544E-1
6.424E-1
 5 385
13 C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 8.074E-4 3.472E-2
2.544E-1
6.887E-1
 5 391
14 C0265101 Carotid artery occlusion DisGeNET BeFree 8.739E-4 3.472E-2
2.544E-1
7.454E-1
 2 23
15 C0206698 Cholangiocarcinoma DisGeNET Curated 9.455E-4 3.472E-2
2.544E-1
8.065E-1
 5 405
16 C1292778 Chronic myeloproliferative disorder DisGeNET BeFree 9.972E-4 3.472E-2
2.544E-1
8.506E-1
 4 235
17 C0001925 Albuminuria DisGeNET Curated 1.034E-3 3.472E-2
2.544E-1
8.818E-1
 2 25
18 C0392386 Decreased platelet count DisGeNET Curated 1.255E-3 3.472E-2
2.544E-1
1.000E0
 3 112
19 C0010692 Cystitis DisGeNET Curated 1.490E-3 3.472E-2
2.544E-1
1.000E0
 2 30
20 C0027726 Nephrotic Syndrome DisGeNET Curated 1.567E-3 3.472E-2
2.544E-1
1.000E0
 3 121
21 C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 1.796E-3 3.472E-2
2.544E-1
1.000E0
 5 468
22 C0015672 Fatigue DisGeNET Curated 1.852E-3 3.472E-2
2.544E-1
1.000E0
 4 278
23 C4020969 Inflammatory abnormality of the eye DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 2 34
24 C0030469 Paranasal Sinus Diseases DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 2 34
25 OMIN:613011 LYMPHOPROLIFERATIVE SYNDROME, EBV-ASSOCIATED, AUTOSOMAL, 1 OMIM 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
26 C0030781 Peliosis Hepatis DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
27 C4023803 Hypertrophy of the lower limb DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
28 C0575518 Hypertrophy of upper limb DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
29 cv:C0878684 SHORT syndrome Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
30 cv:CN219437 Immunodeficiency 36 Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
31 cv:CN074207 Parkes Weber syndrome Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
32 C0265973 Vascular hamartoma of skin DisGeNET BeFree 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
33 C0280251 stage, chronic myelogenous leukemia DisGeNET BeFree 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
34 OMIN:604416 PYOGENIC STERILE ARTHRITIS, PYODERMA GANGRENOSUM, AND ACNE OMIM 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
35 cv:CN219004 Deafness, autosomal recessive 102 Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
36 OMIN:608355 PARKES WEBER SYNDROME OMIM 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
37 cv:C1842180 Capillary malformation-arteriovenous malformation Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
38 OMIN:608354 CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION OMIM 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
39 C2751686 Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1 DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
40 cv:C1858361 Pyogenic arthritis, pyoderma gangrenosum and acne Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
41 C4225167 SPLIT-FOOT MALFORMATION WITH MESOAXIAL POLYDACTYLY DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
42 C0497243 Cardiovascular Neoplasm DisGeNET BeFree 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
43 C3552634 LYMPHOPROLIFERATIVE SYNDROME 1 DisGeNET Curated 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
44 C0036502 Sebaceous Gland Diseases DisGeNET BeFree 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
45 cv:C2751686 Lymphoproliferative syndrome 1 Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
46 cv:CN169371 Agammaglobulinemia 7, autosomal recessive Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
47 cv:C3281001 Wiskott-Aldrich syndrome 2 Clinical Variations 1.913E-3 3.472E-2
2.544E-1
1.000E0
 1 1
48 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 2.336E-3 4.151E-2
3.041E-1
1.000E0
 5 497
49 C0040034 Thrombocytopenia DisGeNET Curated 2.442E-3 4.252E-2
3.115E-1
1.000E0
 4 300
50 C0079772 T-Cell Lymphoma DisGeNET Curated 2.686E-3 4.583E-2
3.358E-1
1.000E0
 4 308
Show 45 more annotations