Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc143_18, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 80 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008022 protein C-terminus binding 9.300E-10 7.440E-8 3.694E-7 7.440E-8 7 224
2 GO:0000268 peroxisome targeting sequence binding 1.504E-8 6.017E-7 2.988E-6 1.203E-6 3 6
3 GO:0047485 protein N-terminus binding 4.196E-6 1.119E-4 5.556E-4 3.357E-4 4 117
4 GO:0005048 signal sequence binding 8.450E-6 1.690E-4 8.391E-4 6.760E-4 3 42
5 GO:0005324 long-chain fatty acid transporter activity 1.840E-5 2.454E-4 1.218E-3 1.472E-3 2 7
6 GO:0003988 acetyl-CoA C-acyltransferase activity 1.840E-5 2.454E-4 1.218E-3 1.472E-3 2 7
7 GO:0015245 fatty acid transmembrane transporter activity 9.159E-5 1.047E-3 5.197E-3 7.327E-3 2 15
8 GO:0005319 lipid transporter activity 1.877E-4 1.877E-3 9.318E-3 1.501E-2 3 118
9 GO:0042623 ATPase activity, coupled 2.472E-4 2.197E-3 1.091E-2 1.977E-2 4 332
10 GO:0000062 fatty-acyl-CoA binding 4.558E-4 3.647E-3 1.811E-2 3.647E-2 2 33
11 GO:0016887 ATPase activity 7.548E-4 4.061E-3 2.017E-2
6.039E-2
 4 446
12 GO:0016408 C-acyltransferase activity 8.116E-4 4.061E-3 2.017E-2
6.493E-2
 2 44
13 GO:0005504 fatty acid binding 9.258E-4 4.061E-3 2.017E-2
7.407E-2
 2 47
14 GO:0004760 serine-pyruvate transaminase activity 9.646E-4 4.061E-3 2.017E-2
7.717E-2
 1 1
15 GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity 9.646E-4 4.061E-3 2.017E-2
7.717E-2
 1 1
16 GO:0033328 peroxisome membrane targeting sequence binding 9.646E-4 4.061E-3 2.017E-2
7.717E-2
 1 1
17 GO:0036105 peroxisome membrane class-1 targeting sequence binding 9.646E-4 4.061E-3 2.017E-2
7.717E-2
 1 1
18 GO:1904121 phosphatidylethanolamine transporter activity 9.646E-4 4.061E-3 2.017E-2
7.717E-2
 1 1
19 GO:0033814 propanoyl-CoA C-acyltransferase activity 9.646E-4 4.061E-3 2.017E-2
7.717E-2
 1 1
20 GO:0043621 protein self-association 1.312E-3 5.249E-3 2.606E-2
1.050E-1
 2 56
21 GO:0031406 carboxylic acid binding 1.486E-3 5.600E-3 2.781E-2
1.189E-1
 3 240
22 GO:0043177 organic acid binding 1.540E-3 5.600E-3 2.781E-2
1.232E-1
 3 243
23 GO:0005052 peroxisome matrix targeting signal-1 binding 1.928E-3 6.428E-3 3.192E-2
1.543E-1
 1 2
24 GO:0008453 alanine-glyoxylate transaminase activity 1.928E-3 6.428E-3 3.192E-2
1.543E-1
 1 2
25 GO:0048037 cofactor binding 2.238E-3 6.958E-3 3.455E-2
1.791E-1
 3 277
26 GO:0042277 peptide binding 2.261E-3 6.958E-3 3.455E-2
1.809E-1
 3 278
27 GO:0033293 monocarboxylic acid binding 2.591E-3 7.677E-3 3.812E-2
2.073E-1
 2 79
28 GO:0036042 long-chain fatty acyl-CoA binding 2.891E-3 7.975E-3 3.960E-2
2.313E-1
 1 3
29 GO:0070538 oleic acid binding 2.891E-3 7.975E-3 3.960E-2
2.313E-1
 1 3
30 GO:0033218 amide binding 3.051E-3 8.082E-3 4.013E-2
2.441E-1
 3 309
31 GO:0051117 ATPase binding 3.132E-3 8.082E-3 4.013E-2
2.505E-1
 2 87
32 GO:0008525 phosphatidylcholine transporter activity 3.853E-3 9.066E-3 4.502E-2
3.082E-1
 1 4
33 GO:0003985 acetyl-CoA C-acetyltransferase activity 3.853E-3 9.066E-3 4.502E-2
3.082E-1
 1 4
34 GO:0016401 palmitoyl-CoA oxidase activity 3.853E-3 9.066E-3 4.502E-2
3.082E-1
 1 4
35 GO:0016453 C-acetyltransferase activity 4.814E-3 1.100E-2
5.464E-2
3.851E-1
 1 5
36 GO:0042626 ATPase activity, coupled to transmembrane movement of substances 4.953E-3 1.101E-2
5.466E-2
3.963E-1
 2 110
37 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity 5.771E-3 1.184E-2
5.881E-2
4.617E-1
 2 119
38 GO:0015399 primary active transmembrane transporter activity 5.771E-3 1.184E-2
5.881E-2
4.617E-1
 2 119
39 GO:0003997 acyl-CoA oxidase activity 5.774E-3 1.184E-2
5.881E-2
4.619E-1
 1 6
40 GO:0043492 ATPase activity, coupled to movement of substances 6.349E-3 1.270E-2
6.305E-2
5.079E-1
 2 125
41 GO:0008526 phosphatidylinositol transporter activity 6.734E-3 1.314E-2
6.524E-2
5.387E-1
 1 7
42 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 8.650E-3 1.648E-2
8.181E-2
6.920E-1
 1 9
43 GO:0017127 cholesterol transporter activity 1.342E-2 2.498E-2
1.240E-1
1.000E0
 1 14
44 GO:0071949 FAD binding 1.438E-2 2.570E-2
1.276E-1
1.000E0
 1 15
45 GO:0050662 coenzyme binding 1.446E-2 2.570E-2
1.276E-1
1.000E0
 2 192
46 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1.533E-2 2.666E-2
1.324E-1
1.000E0
 1 16
47 GO:0015248 sterol transporter activity 1.723E-2 2.813E-2
1.397E-1
1.000E0
 1 18
48 GO:0036041 long-chain fatty acid binding 1.723E-2 2.813E-2
1.397E-1
1.000E0
 1 18
49 GO:0003995 acyl-CoA dehydrogenase activity 1.723E-2 2.813E-2
1.397E-1
1.000E0
 1 18
50 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups 1.854E-2 2.966E-2
1.473E-1
1.000E0
 2 219
Show 45 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 299 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007031 peroxisome organization 1.026E-36 3.068E-34 1.927E-33 3.068E-34 14 35
2 GO:0072662 protein localization to peroxisome 1.684E-31 1.259E-29 7.904E-29 5.035E-29 11 17
3 GO:0072663 establishment of protein localization to peroxisome 1.684E-31 1.259E-29 7.904E-29 5.035E-29 11 17
4 GO:0006625 protein targeting to peroxisome 1.684E-31 1.259E-29 7.904E-29 5.035E-29 11 17
5 GO:0043574 peroxisomal transport 4.329E-31 2.589E-29 1.625E-28 1.294E-28 11 18
6 GO:0044743 protein transmembrane import into intracellular organelle 4.263E-26 2.000E-24 1.256E-23 1.275E-23 11 41
7 GO:0016558 protein import into peroxisome matrix 4.683E-26 2.000E-24 1.256E-23 1.400E-23 9 13
8 GO:0065002 intracellular protein transmembrane transport 3.042E-25 1.137E-23 7.139E-23 9.095E-23 11 48
9 GO:0071806 protein transmembrane transport 1.286E-24 4.272E-23 2.683E-22 3.845E-22 11 54
10 GO:0017038 protein import 2.581E-15 7.486E-14 4.700E-13 7.717E-13 11 351
11 GO:0045046 protein import into peroxisome membrane 2.754E-15 7.486E-14 4.700E-13 8.234E-13 5 6
12 GO:0015919 peroxisomal membrane transport 9.633E-15 2.400E-13 1.507E-12 2.880E-12 5 7
13 GO:0072329 monocarboxylic acid catabolic process 1.093E-11 2.513E-10 1.578E-9 3.267E-9 7 119
14 GO:0022615 protein to membrane docking 4.265E-11 9.109E-10 5.720E-9 1.275E-8 4 8
15 GO:0009062 fatty acid catabolic process 2.828E-10 5.638E-9 3.540E-8 8.457E-8 6 96
16 GO:0019395 fatty acid oxidation 3.413E-10 6.378E-9 4.005E-8 1.020E-7 6 99
17 GO:0034440 lipid oxidation 3.856E-10 6.782E-9 4.258E-8 1.153E-7 6 101
18 GO:0016561 protein import into peroxisome matrix, translocation 7.582E-10 1.259E-8 7.908E-8 2.267E-7 3 3
19 GO:0016054 organic acid catabolic process 1.205E-9 1.801E-8 1.131E-7 3.602E-7 7 232
20 GO:0046395 carboxylic acid catabolic process 1.205E-9 1.801E-8 1.131E-7 3.602E-7 7 232
21 GO:0016557 peroxisome membrane biogenesis 3.031E-9 4.119E-8 2.587E-7 9.062E-7 3 4
22 GO:0016560 protein import into peroxisome matrix, docking 3.031E-9 4.119E-8 2.587E-7 9.062E-7 3 4
23 GO:0006635 fatty acid beta-oxidation 5.754E-9 7.480E-8 4.697E-7 1.720E-6 5 71
24 GO:0000038 very long-chain fatty acid metabolic process 1.648E-8 2.053E-7 1.289E-6 4.927E-6 4 30
25 GO:0044242 cellular lipid catabolic process 2.235E-8 2.673E-7 1.678E-6 6.682E-6 6 198
26 GO:0044282 small molecule catabolic process 3.044E-8 3.500E-7 2.198E-6 9.101E-6 7 370
27 GO:0030258 lipid modification 1.005E-7 1.113E-6 6.989E-6 3.005E-5 6 255
28 GO:0016042 lipid catabolic process 2.780E-7 2.969E-6 1.864E-5 8.313E-5 6 303
29 GO:0022406 membrane docking 6.377E-7 6.575E-6 4.129E-5 1.907E-4 4 73
30 GO:1901091 negative regulation of protein tetramerization 8.824E-7 7.426E-6 4.663E-5 2.638E-4 2 2
31 GO:0060151 peroxisome localization 8.824E-7 7.426E-6 4.663E-5 2.638E-4 2 2
32 GO:1901090 regulation of protein tetramerization 8.824E-7 7.426E-6 4.663E-5 2.638E-4 2 2
33 GO:1901094 negative regulation of protein homotetramerization 8.824E-7 7.426E-6 4.663E-5 2.638E-4 2 2
34 GO:0060152 microtubule-based peroxisome localization 8.824E-7 7.426E-6 4.663E-5 2.638E-4 2 2
35 GO:1901093 regulation of protein homotetramerization 8.824E-7 7.426E-6 4.663E-5 2.638E-4 2 2
36 GO:0006612 protein targeting to membrane 8.941E-7 7.426E-6 4.663E-5 2.673E-4 5 194
37 GO:0006631 fatty acid metabolic process 1.031E-6 8.330E-6 5.231E-5 3.082E-4 6 379
38 GO:0044091 membrane biogenesis 3.695E-6 2.907E-5 1.826E-4 1.105E-3 3 32
39 GO:0032463 negative regulation of protein homooligomerization 1.848E-5 1.381E-4 8.673E-4 5.524E-3 2 7
40 GO:0042760 very long-chain fatty acid catabolic process 1.848E-5 1.381E-4 8.673E-4 5.524E-3 2 7
41 GO:0090150 establishment of protein localization to membrane 2.283E-5 1.665E-4 1.045E-3 6.825E-3 5 377
42 GO:0016559 peroxisome fission 3.952E-5 2.814E-4 1.767E-3 1.182E-2 2 10
43 GO:0032460 negative regulation of protein oligomerization 5.790E-5 4.026E-4 2.528E-3 1.731E-2 2 12
44 GO:0015711 organic anion transport 6.031E-5 4.098E-4 2.573E-3 1.803E-2 5 462
45 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase 6.839E-5 4.445E-4 2.791E-3 2.045E-2 2 13
46 GO:0036109 alpha-linolenic acid metabolic process 6.839E-5 4.445E-4 2.791E-3 2.045E-2 2 13
47 GO:0032462 regulation of protein homooligomerization 1.050E-4 6.682E-4 4.196E-3 3.141E-2 2 16
48 GO:0032373 positive regulation of sterol transport 1.338E-4 8.163E-4 5.126E-3 4.000E-2 2 18
49 GO:0032376 positive regulation of cholesterol transport 1.338E-4 8.163E-4 5.126E-3 4.000E-2 2 18
50 GO:0006869 lipid transport 2.269E-4 1.357E-3 8.521E-3
6.785E-2
 4 324
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044438 microbody part 6.971E-36 9.759E-35 3.833E-34 1.952E-34 16 96
2 GO:0044439 peroxisomal part 6.971E-36 9.759E-35 3.833E-34 1.952E-34 16 96
3 GO:0005778 peroxisomal membrane 3.225E-33 2.258E-32 8.867E-32 9.031E-32 14 58
4 GO:0031903 microbody membrane 3.225E-33 2.258E-32 8.867E-32 9.031E-32 14 58
5 GO:0005777 peroxisome 5.690E-33 2.656E-32 1.043E-31 1.593E-31 16 142
6 GO:0042579 microbody 5.690E-33 2.656E-32 1.043E-31 1.593E-31 16 142
7 GO:0031231 intrinsic component of peroxisomal membrane 8.340E-16 2.919E-15 1.146E-14 2.335E-14 6 14
8 GO:0005779 integral component of peroxisomal membrane 8.340E-16 2.919E-15 1.146E-14 2.335E-14 6 14
9 GO:0031907 microbody lumen 6.831E-10 1.913E-9 7.512E-9 1.913E-8 5 48
10 GO:0005782 peroxisomal matrix 6.831E-10 1.913E-9 7.512E-9 1.913E-8 5 48
11 GO:0031301 integral component of organelle membrane 1.623E-7 4.132E-7 1.623E-6 4.545E-6 6 283
12 GO:0031300 intrinsic component of organelle membrane 2.115E-7 4.936E-7 1.938E-6 5.923E-6 6 296
13 GO:1990415 Pex17p-Pex14p docking complex 9.443E-4 1.889E-3 7.417E-3 2.644E-2 1 1
14 GO:1990429 peroxisomal importomer complex 9.443E-4 1.889E-3 7.417E-3 2.644E-2 1 1
15 GO:0031315 extrinsic component of mitochondrial outer membrane 4.713E-3 8.798E-3 3.455E-2
1.320E-1
 1 5
Show 10 more annotations

4: Human Phenotype [Display Chart] 16 input genes in category / 559 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008167 Very long chain fatty acid accumulation 5.465E-28 3.055E-25 2.109E-24 3.055E-25 11 13
2 HP:0010571 Elevated levels of phytanic acid 9.545E-27 1.779E-24 1.228E-23 5.336E-24 11 15
3 HP:0010965 Abnormality of phytanic acid metabolism 9.545E-27 1.779E-24 1.228E-23 5.336E-24 11 15
4 HP:0001088 Brushfield spots 3.051E-26 3.411E-24 2.355E-23 1.706E-23 11 16
5 HP:0003455 Elevated long chain fatty acids 3.051E-26 3.411E-24 2.355E-23 1.706E-23 11 16
6 HP:0008846 Severe intrauterine growth retardation 8.637E-26 8.047E-24 5.556E-23 4.828E-23 11 17
7 HP:0009716 Subependymal nodules 5.264E-25 4.204E-23 2.903E-22 2.943E-22 11 19
8 HP:0010964 Abnormality of long-chain fatty-acid metabolism 2.452E-24 1.713E-22 1.183E-21 1.371E-21 11 21
9 HP:0003150 Glutaric aciduria 4.899E-24 2.739E-22 1.891E-21 2.739E-21 11 22
10 HP:0007313 Cerebral degeneration 4.899E-24 2.739E-22 1.891E-21 2.739E-21 11 22
11 HP:0012736 Profound global developmental delay 1.730E-23 8.792E-22 6.070E-21 9.671E-21 11 24
12 HP:0003159 Hyperoxaluria 5.770E-23 2.688E-21 1.856E-20 3.226E-20 12 41
13 HP:0009731 Cerebral hamartoma 3.764E-22 1.619E-20 1.118E-19 2.104E-19 11 30
14 HP:0002436 Occipital meningocele 1.330E-21 4.955E-20 3.421E-19 7.433E-19 11 33
15 HP:0010655 Epiphyseal stippling 1.330E-21 4.955E-20 3.421E-19 7.433E-19 11 33
16 HP:0002832 Calcific stippling 4.116E-21 1.438E-19 9.928E-19 2.301E-18 11 36
17 HP:0000803 Renal cortical cysts 3.913E-20 1.215E-18 8.391E-18 2.188E-17 11 43
18 HP:0000627 Posterior embryotoxon 3.913E-20 1.215E-18 8.391E-18 2.188E-17 11 43
19 HP:0008048 Abnormality of the line of Schwalbe 5.213E-20 1.534E-18 1.059E-17 2.914E-17 11 44
20 HP:0011344 Severe global developmental delay 1.095E-19 3.061E-18 2.113E-17 6.121E-17 12 72
21 HP:0004359 Abnormality of fatty-acid metabolism 1.180E-19 3.142E-18 2.169E-17 6.598E-17 11 47
22 HP:0005469 Flat occiput 1.530E-19 3.887E-18 2.684E-17 8.551E-17 11 48
23 HP:0000474 Thickened nuchal skin fold 1.971E-19 4.789E-18 3.307E-17 1.102E-16 11 49
24 HP:0000297 Facial hypotonia 2.524E-19 5.643E-18 3.896E-17 1.411E-16 11 50
25 HP:0003215 Dicarboxylic aciduria 2.524E-19 5.643E-18 3.896E-17 1.411E-16 11 50
26 HP:0010995 Abnormality of dicarboxylic acid metabolism 8.045E-19 1.730E-17 1.194E-16 4.497E-16 11 55
27 HP:0009891 Underdeveloped supraorbital ridges 1.238E-18 2.563E-17 1.770E-16 6.921E-16 11 57
28 HP:0040253 Increased size of the clitoris 2.293E-18 4.134E-17 2.855E-16 1.282E-15 11 60
29 HP:0040252 Abnormal size of the clitoris 2.293E-18 4.134E-17 2.855E-16 1.282E-15 11 60
30 HP:0100740 Embryotoxon 2.293E-18 4.134E-17 2.855E-16 1.282E-15 11 60
31 HP:0008665 Clitoral hypertrophy 2.293E-18 4.134E-17 2.855E-16 1.282E-15 11 60
32 HP:0010656 Abnormal epiphyseal ossification 4.108E-18 7.176E-17 4.954E-16 2.296E-15 11 63
33 HP:0003429 CNS hypomyelination 7.144E-18 1.210E-16 8.355E-16 3.993E-15 11 66
34 HP:0007598 Bilateral single transverse palmar creases 8.539E-18 1.404E-16 9.692E-16 4.773E-15 11 67
35 HP:0004431 Complement deficiency 1.209E-17 1.932E-16 1.334E-15 6.761E-15 11 69
36 HP:0001339 Lissencephaly 1.433E-17 2.226E-16 1.537E-15 8.013E-15 11 70
37 HP:0001992 Organic aciduria 1.931E-17 2.918E-16 2.015E-15 1.080E-14 12 108
38 HP:0011866 Abnormal urine anion concentration 3.409E-17 5.015E-16 3.462E-15 1.906E-14 12 113
39 HP:0008572 External ear malformation 4.396E-17 6.301E-16 4.350E-15 2.457E-14 11 77
40 HP:0011425 Fetal ultrasound soft marker 5.934E-17 8.292E-16 5.725E-15 3.317E-14 11 79
41 HP:0002021 Pyloric stenosis 6.873E-17 9.371E-16 6.470E-15 3.842E-14 11 80
42 HP:0004335 Abnormal formation of myelin sheaths 7.945E-17 1.019E-15 7.036E-15 4.441E-14 11 81
43 HP:0012368 Flat face 7.945E-17 1.019E-15 7.036E-15 4.441E-14 11 81
44 HP:0002415 Leukodystrophy 8.021E-17 1.019E-15 7.036E-15 4.484E-14 12 121
45 HP:0004400 Abnormality of the pylorus 9.167E-17 1.139E-15 7.862E-15 5.124E-14 11 82
46 HP:0002282 Heterotopia 1.056E-16 1.256E-15 8.669E-15 5.901E-14 11 83
47 HP:0000260 Wide anterior fontanel 1.056E-16 1.256E-15 8.669E-15 5.901E-14 11 83
48 HP:0002435 Meningocele 3.071E-16 3.503E-15 2.419E-14 1.717E-13 11 91
49 HP:0008207 Primary adrenal insufficiency 3.071E-16 3.503E-15 2.419E-14 1.717E-13 11 91
50 HP:0100538 Abnormality of the supraorbital ridges 3.948E-16 4.414E-15 3.047E-14 2.207E-13 11 93
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 13 input genes in category / 281 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005365 abnormal bile salt homeostasis 3.066E-7 8.617E-5 5.357E-4 8.617E-5 4 49
2 MP:0012216 decreased plasmalogen level 4.362E-6 3.064E-4 1.905E-3 1.226E-3 2 3
3 MP:0012215 abnormal plasmalogen level 4.362E-6 3.064E-4 1.905E-3 1.226E-3 2 3
4 MP:0012220 abnormal ether lipid level 4.362E-6 3.064E-4 1.905E-3 1.226E-3 2 3
5 MP:0004777 abnormal phospholipid level 7.391E-5 4.154E-3 2.582E-2 2.077E-2 3 68
6 MP:0000599 enlarged liver 2.879E-4 1.307E-2
8.129E-2
8.091E-2
 4 275
7 MP:0005280 abnormal fatty acid level 3.257E-4 1.307E-2
8.129E-2
9.152E-2
 4 284
8 MP:0005281 increased fatty acid level 6.801E-4 2.389E-2
1.485E-1
1.911E-1
 3 144
9 MP:0005085 abnormal gallbladder physiology 9.453E-4 2.940E-2
1.828E-1
2.656E-1
 2 37
10 MP:0003252 abnormal bile duct physiology 1.161E-3 2.940E-2
1.828E-1
3.261E-1
 2 41
11 MP:0012217 increased plasmalogen level 1.255E-3 2.940E-2
1.828E-1
3.528E-1
 1 1
12 MP:0012218 decreased brain plasmalogen level 1.255E-3 2.940E-2
1.828E-1
3.528E-1
 1 1
13 MP:0003634 abnormal glial cell morphology 1.582E-3 3.205E-2
1.993E-1
4.444E-1
 4 432
14 MP:0008288 abnormal adrenal cortex morphology 1.723E-3 3.205E-2
1.993E-1
4.841E-1
 2 50
15 MP:0002139 abnormal hepatobiliary system physiology 1.947E-3 3.205E-2
1.993E-1
5.472E-1
 4 457
16 MP:0008415 abnormal neurite morphology 2.076E-3 3.205E-2
1.993E-1
5.833E-1
 4 465
17 MP:0011635 abnormal mitochondrial crista morphology 2.081E-3 3.205E-2
1.993E-1
5.848E-1
 2 55
18 MP:0011634 abnormal mitochondrial inner membrane morphology 2.233E-3 3.205E-2
1.993E-1
6.276E-1
 2 57
19 MP:0004848 abnormal liver size 2.369E-3 3.205E-2
1.993E-1
6.656E-1
 4 482
20 MP:0002183 gliosis 2.372E-3 3.205E-2
1.993E-1
6.665E-1
 3 222
21 MP:0005404 abnormal axon morphology 2.496E-3 3.205E-2
1.993E-1
7.013E-1
 3 226
22 MP:0011517 hyperoxaluria 2.509E-3 3.205E-2
1.993E-1
7.051E-1
 1 2
23 MP:0002628 hepatic steatosis 3.031E-3 3.703E-2
2.302E-1
8.518E-1
 3 242
24 MP:0001954 respiratory distress 3.594E-3 4.207E-2
2.616E-1
1.000E0
 3 257
Show 19 more annotations

6: Domain [Display Chart] 18 input genes in category / 107 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR006845 Pex N InterPro 2.614E-6 9.972E-5 5.240E-4 2.797E-4 2 3
2 PF04757 Pex2 Pex12 Pfam 2.614E-6 9.972E-5 5.240E-4 2.797E-4 2 3
3 PF06472 ABC membrane 2 Pfam 5.225E-6 9.972E-5 5.240E-4 5.591E-4 2 4
4 SM00382 AAA SMART 9.420E-6 9.972E-5 5.240E-4 1.008E-3 4 144
5 IPR003593 AAA+ ATPase InterPro 9.420E-6 9.972E-5 5.240E-4 1.008E-3 4 144
6 IPR020613 Thiolase CS InterPro 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
7 PF00108 Thiolase N Pfam 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
8 PS00099 THIOLASE 3 PROSITE 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
9 PF02803 Thiolase C Pfam 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
10 IPR020617 Thiolase C InterPro 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
11 PS00098 THIOLASE 1 PROSITE 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
12 PS00737 THIOLASE 2 PROSITE 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
13 IPR020616 Thiolase N InterPro 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
14 IPR002155 Thiolase InterPro 1.305E-5 9.972E-5 5.240E-4 1.396E-3 2 6
15 IPR016039 Thiolase-like InterPro 3.905E-5 2.612E-4 1.372E-3 4.179E-3 2 10
16 3.40.47.10 - Gene3D 3.905E-5 2.612E-4 1.372E-3 4.179E-3 2 10
17 IPR011527 ABC1 TM dom InterPro 3.247E-4 1.930E-3 1.014E-2 3.474E-2 2 28
18 PS50929 ABC TM1F PROSITE 3.247E-4 1.930E-3 1.014E-2 3.474E-2 2 28
19 IPR003960 ATPase AAA CS InterPro 3.486E-4 1.963E-3 1.031E-2 3.730E-2 2 29
20 PS00674 AAA PROSITE 4.803E-4 2.142E-3 1.125E-2
5.139E-2
 2 34
21 IPR017871 ABC transporter CS InterPro 7.338E-4 2.142E-3 1.125E-2
7.851E-2
 2 42
22 PF00005 ABC tran Pfam 9.580E-4 2.142E-3 1.125E-2
1.025E-1
 2 48
23 PS50893 ABC TRANSPORTER 2 PROSITE 9.580E-4 2.142E-3 1.125E-2
1.025E-1
 2 48
24 IPR031239 ABCD2 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
25 PF04695 Pex14 N Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
26 PF08610 Pex16 Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
27 IPR013919 Pex16 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
28 PF04088 Peroxin-13 N Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
29 IPR025654 PEX10 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
30 PF09263 PEX-2N Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
31 PF07163 Pex26 Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
32 PF04882 Peroxin-3 Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
33 IPR006966 Peroxin-3 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
34 IPR025653 Pex1 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
35 PF04614 Pex19 Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
36 IPR024169 SP NH2Trfase/AEP transaminase InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
37 IPR025655 PEX14 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
38 IPR006785 Pex14 N InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
39 IPR015342 PEX-N psi beta-barrel InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
40 IPR006708 Pex19 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
41 IPR031241 ABCD3 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
42 PF10343 Q salvage Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
43 IPR019438 Q salvage InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
44 IPR017375 PEX12 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
45 IPR007223 Peroxin-13 N InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
46 IPR010797 Pex26 InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
47 IPR015343 PEX-N a/b InterPro 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
48 PF09262 PEX-1N Pfam 9.608E-4 2.142E-3 1.125E-2
1.028E-1
 1 1
49 PS00211 ABC TRANSPORTER 1 PROSITE 9.982E-4 2.180E-3 1.145E-2
1.068E-1
 2 49
50 IPR003439 ABC transporter-like InterPro 1.039E-3 2.224E-3 1.169E-2
1.112E-1
 2 50
Show 45 more annotations

7: Pathway [Display Chart] 17 input genes in category / 77 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 131226 Peroxisome BioSystems: KEGG 5.545E-35 4.269E-33 2.104E-32 4.269E-33 16 83
2 1269905 ABC transporters in lipid homeostasis BioSystems: REACTOME 7.194E-9 2.770E-7 1.365E-6 5.539E-7 4 18
3 1269904 ABC-family proteins mediated transport BioSystems: REACTOME 1.257E-5 3.225E-4 1.589E-3 9.676E-4 4 110
4 782404 fatty acid beta-oxidation (peroxisome) BioSystems: BIOCYC 1.357E-4 2.340E-3 1.153E-2 1.045E-2 2 13
5 1270084 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism BioSystems: REACTOME 1.824E-4 2.340E-3 1.153E-2 1.404E-2 2 15
6 1270085 alpha-linolenic acid (ALA) metabolism BioSystems: REACTOME 1.824E-4 2.340E-3 1.153E-2 1.404E-2 2 15
7 83002 Glyoxylate and dicarboxylate metabolism BioSystems: KEGG 6.497E-4 6.711E-3 3.307E-2
5.002E-2
 2 28
8 1270031 Peroxisomal lipid metabolism BioSystems: REACTOME 6.972E-4 6.711E-3 3.307E-2
5.369E-2
 2 29
9 SMP00352 Primary Hyperoxaluria Type I SMPDB 1.365E-3 1.168E-2
5.756E-2
1.051E-1
 1 1
10 82935 Fatty acid degradation BioSystems: KEGG 1.605E-3 1.175E-2
5.789E-2
1.236E-1
 2 44
11 83035 ABC transporters BioSystems: KEGG 1.678E-3 1.175E-2
5.789E-2
1.292E-1
 2 45
12 868084 Fatty acid metabolism BioSystems: KEGG 1.908E-3 1.224E-2
6.032E-2
1.469E-1
 2 48
13 SMP00316 Zellweger Syndrome SMPDB 2.729E-3 1.501E-2
7.396E-2
2.101E-1
 1 2
14 142151 glycine biosynthesis BioSystems: BIOCYC 2.729E-3 1.501E-2
7.396E-2
2.101E-1
 1 2
15 83042 PPAR signaling pathway BioSystems: KEGG 4.241E-3 2.177E-2
1.073E-1
3.265E-1
 2 72
16 142409 glutaryl-CoA degradation BioSystems: BIOCYC 5.451E-3 2.623E-2
1.293E-1
4.198E-1
 1 4
17 SMP00055 Alanine Metabolism SMPDB 6.810E-3 2.983E-2
1.470E-1
5.244E-1
 1 5
18 1270034 Beta-oxidation of very long chain fatty acids BioSystems: REACTOME 8.166E-3 2.983E-2
1.470E-1
6.288E-1
 1 6
19 814926 Carbon metabolism BioSystems: KEGG 1.033E-2 2.983E-2
1.470E-1
7.956E-1
 2 114
20 SMP00052 Beta Oxidation of Very Long Chain Fatty Acids SMPDB 1.087E-2 2.983E-2
1.470E-1
8.373E-1
 1 8
21 SMP00030 Oxidation of Branched Chain Fatty Acids SMPDB 1.358E-2 2.983E-2
1.470E-1
1.000E0
 1 10
22 142207 mevalonate pathway BioSystems: BIOCYC 1.358E-2 2.983E-2
1.470E-1
1.000E0
 1 10
23 1270033 Beta-oxidation of pristanoyl-CoA BioSystems: REACTOME 1.358E-2 2.983E-2
1.470E-1
1.000E0
 1 10
24 82936 Synthesis and degradation of ketone bodies BioSystems: KEGG 1.358E-2 2.983E-2
1.470E-1
1.000E0
 1 10
25 413387 C5 isoprenoid biosynthesis, mevalonate pathway BioSystems: KEGG 1.358E-2 2.983E-2
1.470E-1
1.000E0
 1 10
26 PW:0000028 alanine and aspartate metabolic Pathway Ontology 1.358E-2 2.983E-2
1.470E-1
1.000E0
 1 10
27 SMP00095 Alendronate pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
28 SMP00107 Zoledronate Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
29 SMP00112 Risedronate Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
30 545288 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) BioSystems: BIOCYC 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
31 SMP00119 Fluvastatin Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
32 413432 Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate BioSystems: KEGG 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
33 SMP00079 Ibandronate Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
34 SMP00099 Lovastatin Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
35 SMP00117 Pamidronate Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
36 SMP00131 Atorvastatin Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
37 413381 beta-Oxidation BioSystems: KEGG 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
38 545316 bile acid biosynthesis, neutral pathway BioSystems: BIOCYC 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
39 SMP00089 Pravastatin Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
40 SMP00092 Rosuvastatin Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
41 142358 isoleucine degradation BioSystems: BIOCYC 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
42 SMP00111 Cerivastatin Pathway SMPDB 1.627E-2 2.983E-2
1.470E-1
1.000E0
 1 12
43 142421 fatty acid beta-oxidation BioSystems: BIOCYC 1.896E-2 3.318E-2
1.635E-1
1.000E0
 1 14
44 PW:0000047 glycine, serine and threonine metabolic Pathway Ontology 1.896E-2 3.318E-2
1.635E-1
1.000E0
 1 14
45 SMP00035 Bile Acid Biosynthesis SMPDB 2.298E-2 3.846E-2
1.895E-1
1.000E0
 1 17
46 82938 Primary bile acid biosynthesis BioSystems: KEGG 2.298E-2 3.846E-2
1.895E-1
1.000E0
 1 17
47 SMP00192 Hypoacetylaspartia SMPDB 2.431E-2 3.900E-2
1.922E-1
1.000E0
 1 18
48 PW:0000454 cholesterol biosynthetic Pathway Ontology 2.431E-2 3.900E-2
1.922E-1
1.000E0
 1 18
49 MAP00252 Alanine and aspartate metabolism MAP00252 Alanine and aspartate metabolism GenMAPP 2.831E-2 4.360E-2
2.148E-1
1.000E0
 1 21
50 SMP00023 Steroid Biosynthesis SMPDB 2.831E-2 4.360E-2
2.148E-1
1.000E0
 1 21
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 716 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20301621 Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum Pubmed 3.932E-37 2.816E-34 2.014E-33 2.816E-34 11 13
2 24501781 Leukodystrophy Overview Pubmed 2.098E-34 7.510E-32 5.371E-31 1.502E-31 13 55
3 10704444 PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. Pubmed 1.167E-27 2.784E-25 1.991E-24 8.353E-25 9 16
4 12096124 Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. Pubmed 3.509E-27 6.281E-25 4.492E-24 2.512E-24 8 9
5 21525035 PEX14 is required for microtubule-based peroxisome motility in human cells. Pubmed 5.712E-25 8.180E-23 5.850E-22 4.090E-22 10 54
6 11390669 Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. Pubmed 3.015E-20 3.598E-18 2.573E-17 2.159E-17 6 7
7 19105186 Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. Pubmed 1.265E-17 1.294E-15 9.257E-15 9.061E-15 5 5
8 9922452 Peroxisome synthesis in the absence of preexisting peroxisomes. Pubmed 2.656E-16 2.377E-14 1.700E-13 1.902E-13 5 7
9 22002062 Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix. Pubmed 1.613E-15 1.284E-13 9.179E-13 1.155E-12 6 28
10 10562279 PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. Pubmed 3.452E-14 2.472E-12 1.768E-11 2.472E-11 4 4
11 10837480 Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. Pubmed 1.725E-13 1.030E-11 7.363E-11 1.235E-10 4 5
12 11883941 Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. Pubmed 1.725E-13 1.030E-11 7.363E-11 1.235E-10 4 5
13 20531392 The peroxisomal receptor Pex19p forms a helical mPTS recognition domain. Pubmed 2.414E-12 1.329E-10 9.507E-10 1.728E-9 4 8
14 14709540 PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. Pubmed 7.236E-12 3.701E-10 2.647E-9 5.181E-9 4 10
15 14561759 Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Pubmed 6.260E-11 2.247E-9 1.607E-8 4.483E-8 4 16
16 9653144 Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
17 16257970 Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
18 19584060 Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
19 27311714 Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
20 19197237 Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
21 25016021 AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
22 15713480 Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
23 28765278 The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
24 12717447 The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
25 16449325 Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
26 14715663 Potential role for Pex19p in assembly of PTS-receptor docking complexes. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
27 16854980 Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
28 21375735 The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition. Pubmed 8.789E-11 2.247E-9 1.607E-8 6.293E-8 3 3
29 10777694 Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p. Pubmed 3.514E-10 8.117E-9 5.805E-8 2.516E-7 3 4
30 11865044 Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import. Pubmed 3.514E-10 8.117E-9 5.805E-8 2.516E-7 3 4
31 21102411 Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p. Pubmed 3.514E-10 8.117E-9 5.805E-8 2.516E-7 3 4
32 19479899 Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts. Pubmed 8.784E-10 1.965E-8 1.406E-7 6.289E-7 3 5
33 17881773 Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Pubmed 1.756E-9 3.810E-8 2.725E-7 1.257E-6 3 6
34 10504404 The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression. Pubmed 3.072E-9 6.470E-8 4.627E-7 2.200E-6 3 7
35 20178365 A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Pubmed 4.631E-9 9.475E-8 6.776E-7 3.316E-6 4 44
36 17208939 Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. Pubmed 6.631E-9 1.319E-7 9.431E-7 4.748E-6 4 48
37 11171065 Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Pubmed 1.052E-8 2.037E-7 1.457E-6 7.536E-6 3 10
38 24235149 A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
39 16280322 In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
40 27302843 Spectrum of PEX1 and PEX6 variants in Heimler syndrome. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
41 22529745 Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
42 9288097 A mouse model for Zellweger syndrome. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
43 22624858 The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
44 8858165 Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
45 19715730 The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
46 25062251 Association between the intrinsically disordered protein PEX19 and PEX3. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
47 11453642 Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
48 16895967 Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
49 9398847 Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
50 27633571 Severe early onset retinitis pigmentosa in a Moroccan patient with Heimler syndrome due to novel homozygous mutation of PEX1 gene. Pubmed 2.098E-7 2.242E-6 1.603E-5 1.502E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 18 input genes in category / 493 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PEX19 PEX19 interactions 8.198E-18 4.042E-15 2.740E-14 4.042E-15 10 124
2 int:PEX14 PEX14 interactions 2.613E-17 6.441E-15 4.366E-14 1.288E-14 9 81
3 int:PEX12 PEX12 interactions 3.548E-15 5.830E-13 3.952E-12 1.749E-12 5 6
4 int:PEX5 PEX5 interactions 2.531E-14 3.120E-12 2.115E-11 1.248E-11 8 97
5 int:PEX10 PEX10 interactions 5.029E-12 4.959E-10 3.361E-9 2.479E-9 5 18
6 int:PEX26 PEX26 interactions 2.613E-11 2.147E-9 1.455E-8 1.288E-8 4 7
7 int:PEX3 PEX3 interactions 9.395E-11 6.617E-9 4.485E-8 4.632E-8 4 9
8 int:PEX13 PEX13 interactions 3.684E-10 2.270E-8 1.539E-7 1.816E-7 4 12
9 int:ABCD2 ABCD2 interactions 8.815E-9 4.829E-7 3.273E-6 4.346E-6 3 5
10 int:AGPS AGPS interactions 1.749E-8 8.541E-7 5.790E-6 8.621E-6 4 29
11 int:ABCD1 ABCD1 interactions 2.016E-8 8.541E-7 5.790E-6 9.941E-6 4 30
12 int:ABCD3 ABCD3 interactions 2.079E-8 8.541E-7 5.790E-6 1.025E-5 5 87
13 int:PEX2 PEX2 interactions 3.081E-8 1.169E-6 7.921E-6 1.519E-5 3 7
14 int:PEX16 PEX16 interactions 2.508E-7 8.833E-6 5.988E-5 1.237E-4 3 13
15 int:PEX1 PEX1 interactions 7.134E-7 2.345E-5 1.589E-4 3.517E-4 3 18
16 int:PEX6 PEX6 interactions 1.543E-6 4.756E-5 3.224E-4 7.609E-4 3 23
17 int:PEX7 PEX7 interactions 2.846E-6 8.253E-5 5.595E-4 1.403E-3 3 28
18 int:ACOX1 ACOX1 interactions 7.884E-6 2.159E-4 1.464E-3 3.887E-3 3 39
19 int:SCP2 SCP2 interactions 1.139E-5 2.955E-4 2.003E-3 5.615E-3 3 44
20 int:AGXT AGXT interactions 2.044E-5 5.039E-4 3.416E-3 1.008E-2 2 7
21 int:HSD17B4 HSD17B4 interactions 2.366E-5 5.553E-4 3.765E-3 1.166E-2 3 56
22 int:TYSND1 TYSND1 interactions 5.341E-5 1.197E-3 8.114E-3 2.633E-2 2 11
23 int:NEU2 NEU2 interactions 2.229E-4 4.777E-3 3.238E-2
1.099E-1
 2 22
24 int:ACAA1 ACAA1 interactions 5.060E-4 1.039E-2
7.046E-2
2.495E-1
 2 33
25 int:EHHADH EHHADH interactions 5.696E-4 1.123E-2
7.614E-2
2.808E-1
 2 35
26 int:GNPAT GNPAT interactions 6.717E-4 1.274E-2
8.634E-2
3.312E-1
 2 38
27 int:ECI2 ECI2 interactions 7.076E-4 1.292E-2
8.758E-2
3.488E-1
 2 39
28 int:SLC27A2 SLC27A2 interactions 7.821E-4 1.377E-2
9.335E-2
3.856E-1
 2 41
29 int:FAM174A FAM174A interactions 1.116E-3 1.898E-2
1.286E-1
5.503E-1
 2 49
30 int:MPV17 MPV17 interactions 1.209E-3 1.986E-2
1.347E-1
5.959E-1
 2 51
31 int:DHRS4 DHRS4 interactions 1.354E-3 2.154E-2
1.460E-1
6.676E-1
 2 54
32 int:CAT CAT interactions 1.456E-3 2.243E-2
1.520E-1
7.176E-1
 2 56
33 int:CD79A CD79A interactions 1.781E-3 2.661E-2
1.804E-1
8.780E-1
 2 62
34 int:MKRN3 MKRN3 interactions 1.838E-3 2.665E-2
1.807E-1
9.063E-1
 2 63
35 int:PAOX PAOX interactions 2.033E-3 2.708E-2
1.836E-1
1.000E0
 1 2
36 int:ACOT4 ACOT4 interactions 2.033E-3 2.708E-2
1.836E-1
1.000E0
 1 2
37 int:TM6SF1 TM6SF1 interactions 2.033E-3 2.708E-2
1.836E-1
1.000E0
 1 2
38 int:SCN3B SCN3B interactions 2.200E-3 2.854E-2
1.935E-1
1.000E0
 2 69
39 int:THBS3 THBS3 interactions 2.264E-3 2.861E-2
1.940E-1
1.000E0
 2 70
40 int:ACAT1 ACAT1 interactions 2.393E-3 2.949E-2
1.999E-1
1.000E0
 2 72
41 int:DKKL1 DKKL1 interactions 2.662E-3 3.200E-2
2.170E-1
1.000E0
 2 76
42 int:CHST7 CHST7 interactions 3.047E-3 3.312E-2
2.245E-1
1.000E0
 1 3
43 int:NUDT7 NUDT7 interactions 3.047E-3 3.312E-2
2.245E-1
1.000E0
 1 3
44 int:PXMP4 PXMP4 interactions 3.047E-3 3.312E-2
2.245E-1
1.000E0
 1 3
45 int:ZNF772 ZNF772 interactions 3.047E-3 3.312E-2
2.245E-1
1.000E0
 1 3
46 int:MYO5A MYO5A interactions 3.090E-3 3.312E-2
2.245E-1
1.000E0
 2 82
47 int:DDO DDO interactions 4.061E-3 4.148E-2
2.812E-1
1.000E0
 1 4
48 int:MGAT2 MGAT2 interactions 4.061E-3 4.148E-2
2.812E-1
1.000E0
 1 4
49 int:C3AR1 C3AR1 interactions 4.123E-3 4.148E-2
2.812E-1
1.000E0
 2 95
50 int:MYO5C MYO5C interactions 4.557E-3 4.389E-2
2.975E-1
1.000E0
 2 100
Show 45 more annotations

10: Cytoband [Display Chart] 18 input genes in category / 18 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q21.2 7q21.2 8.279E-3 3.612E-2
1.262E-1
1.490E-1
 1 16
2 6q24.2 6q24.2 9.824E-3 3.612E-2
1.262E-1
1.768E-1
 1 19
3 9q21.32 9q21.32 9.824E-3 3.612E-2
1.262E-1
1.768E-1
 1 19
4 1p21.3 1p21.3 1.188E-2 3.612E-2
1.262E-1
2.138E-1
 1 23
5 1p36.32 1p36.32 1.342E-2 3.612E-2
1.262E-1
2.416E-1
 1 26
6 1p32 1p32 1.393E-2 3.612E-2
1.262E-1
2.508E-1
 1 27
7 2p16.1 2p16.1 1.649E-2 3.612E-2
1.262E-1
2.969E-1
 1 32
8 6q25.3 6q25.3 1.803E-2 3.612E-2
1.262E-1
3.245E-1
 1 35
9 1q23.2 1q23.2 1.854E-2 3.612E-2
1.262E-1
3.336E-1
 1 36
10 1p36.22 1p36.22 2.007E-2 3.612E-2
1.262E-1
3.612E-1
 1 39
11 12q12 12q12 2.413E-2 3.949E-2
1.380E-1
4.344E-1
 1 47
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 34 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 13 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 957 Peroxins genenames.org 1.885E-34 1.131E-33 2.772E-33 1.131E-33 11 16
2 808 ATP binding cassette subfamily D genenames.org 2.825E-6 8.476E-6 2.077E-5 1.695E-5 2 4
3 413 AAA ATPases genenames.org 6.362E-4 1.272E-3 3.118E-3 3.817E-3 2 53
4 1062 ATP binding cassette subfamily D|GOLD domain containing genenames.org 2.142E-3 3.213E-3 7.872E-3 1.285E-2 1 3

13: Coexpression [Display Chart] 18 input genes in category / 1377 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5948 Genes involve in metabolism of bile acids and salts. MSigDB H: Hallmark Gene Sets (v6.0) 6.388E-22 8.796E-19 6.865E-18 8.796E-19 11 112
2 M5949 Genes encoding components of peroxisome. MSigDB H: Hallmark Gene Sets (v6.0) 5.339E-15 3.676E-12 2.869E-11 7.352E-12 8 104
3 14562049-Table2 Human StemCell Young03 142genes GeneSigDB 4.070E-10 1.868E-7 1.458E-6 5.605E-7 6 126
4 15375163-SuppTable2 Mouse Liver Anderson04 41genes GeneSigDB 9.094E-9 3.131E-6 2.443E-5 1.252E-5 4 32
5 16498405-TableS4 Mouse Kidney Takemoto06 388genes cat2 GeneSigDB 2.559E-6 7.049E-4 5.502E-3 3.524E-3 5 298
6 M12107 Genes down-regulated in corneal fibroblasts after treatment with IL1A [GeneID=3552]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.682E-5 6.156E-3 4.805E-2 3.694E-2 3 76
7 M2420 Genes with promoters bound by both PPARG and RXRA [GeneID=5468, 6256] at 8 (but not 0) day time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte) and that were newly modified by H4K20me1. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.836E-4 2.423E-2
1.891E-1
2.528E-1
 3 145
8 M8811 Genes down-regulated in splenocytes from Foxp3-ires-GFP B6 mice: T reg (FOXP3+ [GeneID=50943]) versus T conv (FOXP3- [GeneID=50943]). MSigDB C7: Immunologic Signatures (v6.0) 2.029E-4 2.423E-2
1.891E-1
2.794E-1
 3 150
9 15604263-Table2 Human StemCell Gillet04 57genes GeneSigDB 2.623E-4 2.423E-2
1.891E-1
3.612E-1
 2 31
10 18277965-TableS1b Human Liver Skawran08 551genes GeneSigDB 2.800E-4 2.423E-2
1.891E-1
3.856E-1
 4 425
11 15598354-SuppTable7b Human Breast Shen04 45genes DownRegulated GeneSigDB 3.746E-4 2.423E-2
1.891E-1
5.159E-1
 2 37
12 M1678 Strongly up-regulated at 96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.999E-4 2.423E-2
1.891E-1
5.507E-1
 3 189
13 19010862-TableS2 Human Breast Laere08 205genes GeneSigDB 4.514E-4 2.423E-2
1.891E-1
6.216E-1
 3 197
14 M8379 Genes down-regulated in CD4 [GeneID=920] T cells: progesterone [PubChem=5994] versus TGFB1 [GeneID=7040] and progesterone [PubChem=5994]. MSigDB C7: Immunologic Signatures (v6.0) 4.582E-4 2.423E-2
1.891E-1
6.309E-1
 3 198
15 M5414 Genes down-regulated in comparison of eosinophils versus basophils. MSigDB C7: Immunologic Signatures (v6.0) 4.582E-4 2.423E-2
1.891E-1
6.309E-1
 3 198
16 M5337 Genes up-regulated in comparison of control polymorphonuclear leukocytes (PMN) at 24 h versus PMN treated with F. tularensis vaccine at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 4.649E-4 2.423E-2
1.891E-1
6.402E-1
 3 199
17 M4463 Genes down-regulated in comparison of monocytes cultured for 1 day versus those cultured for 7 days. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
18 M3705 Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with poly(I:C) (TLR3 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
19 M7755 Genes down-regulated in macrophages after M. bovis BCG infection: 24h versus 48h. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
20 M6280 Genes down-regulated in thymic macrophages versus medullary thymic epithelial cells (mTEC). MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
21 M6091 Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (2h). MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
22 M5905 Genes up-regulated during adipocyte differentiation (adipogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
23 M7697 Genes up-regulated in CD4 [GeneID=920] T cells: control versus tretinoin [PubChem=444795]. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
24 M6950 Genes up-regulated in plasmacytoid dendritic cells (1h): CpG oligodeoxynucleotide 1826 versus influenza virus infection. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
25 M7686 Genes down-regulated in ankle joints over-expressing TNF [GeneID=7124]: SPHK1 [GeneID=8877] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
26 M7267 Genes down-regulated in double positive thymocytes: wildtype versus TCF3 [GeneID=6929] knockout. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 2.423E-2
1.891E-1
6.497E-1
 3 200
27 18339850-Table1 Human Lung Tessema08 43genes GeneSigDB 4.832E-4 2.423E-2
1.891E-1
6.654E-1
 2 42
28 M10431 Genes down-regulated in pancreatic ductal adenocarcinoma (PDAC) identified in a meta analysis across four independent studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.927E-4 2.423E-2
1.891E-1
6.785E-1
 3 203
29 19266166-Table1 Human Eye+J425 Hendig09 48genes GeneSigDB 6.053E-4 2.821E-2
2.202E-1
8.334E-1
 2 47
30 16423883-Table1S Mouse Liver Jeong06 270genes GeneSigDB 6.145E-4 2.821E-2
2.202E-1
8.462E-1
 3 219
31 M5547 Age up-regulated genes in the human frontal cortex. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.033E-3 4.588E-2
3.581E-1
1.000E0
 3 262
32 20101236-SuppTable7a Human Breast Turner10 324genes GeneSigDB 1.138E-3 4.899E-2
3.823E-1
1.000E0
 3 271
Show 27 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 549 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 13 input genes in category / 62 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M741 MODULE 327 Genes in the cancer module 327. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.207E-4 1.989E-2
9.371E-2
 1.989E-2 2 21
2 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.586E-3 4.917E-2
2.317E-1
9.833E-2
 3 187

16: MicroRNA [Display Chart] 18 input genes in category / 570 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4703-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.848E-5 1.786E-2
1.236E-1
 3.903E-2 2 49
2 hsa-miR-4774-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.327E-5 1.786E-2
1.236E-1
 4.746E-2 2 54
3 hsa-miR-183-5p.1:TargetScan hsa-miR-183-5p.1 TargetScan 1.011E-4 1.786E-2
1.236E-1
5.761E-2
 3 368
4 hsa-miR-1247:mirSVR highEffct hsa-miR-1247:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.525E-4 1.786E-2
1.236E-1
8.692E-2
 2 73
5 hsa-miR-548s:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.566E-4 1.786E-2
1.236E-1
8.928E-2
 3 427
6 hsa-miR-4733-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.019E-4 1.918E-2
1.328E-1
1.151E-1
 2 84
7 hsa-miR-490-3p:mirSVR highEffct hsa-miR-490-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 2.475E-4 1.958E-2
1.355E-1
1.410E-1
 3 499
8 hsa-miR-6742-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.748E-4 1.958E-2
1.355E-1
1.566E-1
 2 98
9 hsa-miR-5003-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.511E-4 3.323E-2
2.301E-1
3.141E-1
 2 139
10 hsa-miR-483-5p:Functional MTI Functional MTI miRTarbase 5.831E-4 3.323E-2
2.301E-1
3.323E-1
 2 143
11 hsa-miR-126:PITA hsa-miR-126:PITA TOP PITA 9.963E-4 4.446E-2
3.078E-1
5.679E-1
 1 4
12 hsa-miR-376b-3p:TargetScan hsa-miR-376b-3p TargetScan 1.156E-3 4.446E-2
3.078E-1
6.588E-1
 2 202
13 hsa-miR-376a-3p:TargetScan hsa-miR-376a-3p TargetScan 1.156E-3 4.446E-2
3.078E-1
6.588E-1
 2 202
14 hsa-miR-7113-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.190E-3 4.446E-2
3.078E-1
6.782E-1
 2 205
15 hsa-miR-4781-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.236E-3 4.446E-2
3.078E-1
7.046E-1
 2 209
16 hsa-miR-4423-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.248E-3 4.446E-2
3.078E-1
7.113E-1
 2 210
17 hsa-miR-769-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.480E-3 4.712E-2
3.263E-1
8.438E-1
 2 229
18 hsa-miR-1193:TargetScan hsa-miR-1193 TargetScan 1.545E-3 4.712E-2
3.263E-1
8.805E-1
 2 234
19 hsa-miR-744-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.571E-3 4.712E-2
3.263E-1
8.953E-1
 2 236
20 hsa-miR-6787-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.787E-3 4.962E-2
3.436E-1
1.000E0
 2 252
21 hsa-miR-6771-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.829E-3 4.962E-2
3.436E-1
1.000E0
 2 255
22 hsa-miR-4786-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.988E-3 4.962E-2
3.436E-1
1.000E0
 2 266
23 hsa-miR-216a-5p:TargetScan hsa-miR-216a-5p TargetScan 2.002E-3 4.962E-2
3.436E-1
1.000E0
 2 267
Show 18 more annotations

17: Drug [Display Chart] 18 input genes in category / 4492 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000070065 Pb-D Stitch 1.083E-25 4.867E-22 4.374E-21 4.867E-22 13 143
2 CID000072508 pip-pip Stitch 2.176E-24 4.888E-21 4.393E-20 9.775E-21 11 68
3 CID000026840 phytanic acid Stitch 4.518E-20 5.117E-17 4.598E-16 2.029E-16 10 96
4 CID000010469 C26:0 Stitch 4.556E-20 5.117E-17 4.598E-16 2.047E-16 9 53
5 CID000000849 pipecolic acid Stitch 6.008E-17 5.150E-14 4.628E-13 2.699E-13 9 113
6 CID000011197 C24:0 Stitch 6.878E-17 5.150E-14 4.628E-13 3.090E-13 8 61
7 CID000123929 pristanic acid Stitch 1.033E-16 6.626E-14 5.955E-13 4.639E-13 8 64
8 CID006441476 hexacosenoic acid Stitch 6.977E-15 3.918E-12 3.521E-11 3.134E-11 6 22
9 CID000004341 N-acetyl-LTE4 Stitch 3.513E-14 1.754E-11 1.576E-10 1.578E-10 6 28
10 CID000126362 P9OH Stitch 3.298E-13 1.482E-10 1.332E-9 1.482E-9 5 14
11 CID000122312 trihydroxycholestanoic acid Stitch 5.520E-12 2.254E-9 2.026E-8 2.480E-8 5 23
12 CID000031072 carbimazole Stitch 9.145E-12 3.423E-9 3.076E-8 4.108E-8 6 67
13 CID000131223 Skl tripeptide Stitch 1.383E-10 4.779E-8 4.295E-7 6.212E-7 5 42
14 CID000008082 piperidine Stitch 5.311E-10 1.704E-7 1.532E-6 2.386E-6 6 130
15 CID000132608 Distel Stitch 8.202E-10 2.456E-7 2.208E-6 3.684E-6 4 18
16 CID000008617 indole-3-butyric acid Stitch 6.332E-9 1.778E-6 1.598E-5 2.844E-5 4 29
17 CID000000668 dihydroxyacetone phosphate Stitch 1.009E-7 2.665E-5 2.395E-4 4.531E-4 5 153
18 CID000000760 glyoxylate Stitch 2.027E-7 5.059E-5 4.546E-4 9.105E-4 5 176
19 CID000033166 IPMP Stitch 2.286E-7 5.406E-5 4.858E-4 1.027E-3 3 16
20 CID000003144 AC1L1F9Q Stitch 3.919E-7 8.796E-5 7.906E-4 1.761E-3 5 201
21 CID000003909 11-trans-leukotriene E4 Stitch 4.112E-7 8.796E-5 7.906E-4 1.847E-3 4 80
22 CID000000303 sodium cholate Stitch 4.847E-7 9.897E-5 8.895E-4 2.177E-3 6 408
23 CID000000965 mangrove Stitch 1.079E-6 2.108E-4 1.895E-3 4.848E-3 6 468
24 CID000449034 1vcj Stitch 1.188E-6 2.223E-4 1.998E-3 5.336E-3 3 27
25 CID003015677 N-nitro-N-nitrosoguanidine Stitch 3.516E-6 6.318E-4 5.678E-3 1.579E-2 2 4
26 CID000000971 oxalate Stitch 6.254E-6 1.079E-3 9.695E-3 2.809E-2 4 158
27 CID000461545 AGEPC Stitch 6.484E-6 1.079E-3 9.695E-3 2.913E-2 5 356
28 ctd:D005227 Fatty Acids CTD 1.171E-5 1.663E-3 1.494E-2
5.259E-2
 3 57
29 CID005282747 (E)-heptadec-2-enoic acid Stitch 1.229E-5 1.663E-3 1.494E-2
5.520E-2
 2 7
30 ctd:C088563 fomesafen CTD 1.229E-5 1.663E-3 1.494E-2
5.520E-2
 2 7
31 1306 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.243E-5 1.663E-3 1.494E-2
5.583E-2
 4 188
32 1363 DN Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; HL60; HG-U133A Broad Institute CMAP Down 1.378E-5 1.663E-3 1.494E-2
6.191E-2
 4 193
33 1754 DN Tomatidine [77-59-8]; Down 200; 9.6uM; HL60; HG-U133A Broad Institute CMAP Down 1.435E-5 1.663E-3 1.494E-2
6.447E-2
 4 195
34 2390 DN Glutethimide, para-amino [125-84-8]; Down 200; 17.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.464E-5 1.663E-3 1.494E-2
6.578E-2
 4 196
35 2950 DN Roxarsone [121-19-7]; Down 200; 15.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.464E-5 1.663E-3 1.494E-2
6.578E-2
 4 196
36 5868 DN Cefmetazole sodium salt [56796-39-5]; Down 200; 8.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.464E-5 1.663E-3 1.494E-2
6.578E-2
 4 196
37 7513 DN DNA-PK Inhibitor III; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.464E-5 1.663E-3 1.494E-2
6.578E-2
 4 196
38 1335 DN Brompheniramine maleate [980-71-2]; Down 200; 9.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.494E-5 1.663E-3 1.494E-2
6.711E-2
 4 197
39 2541 UP Propidium iodide [25535-16-4]; Up 200; 6uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.494E-5 1.663E-3 1.494E-2
6.711E-2
 4 197
40 3087 DN Nitrendipine [39562-70-4]; Down 200; 11uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.524E-5 1.663E-3 1.494E-2
6.846E-2
 4 198
41 1295 UP Testosterone propionate [57-85-2]; Up 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.555E-5 1.663E-3 1.494E-2
6.983E-2
 4 199
42 5820 UP Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.555E-5 1.663E-3 1.494E-2
6.983E-2
 4 199
43 CID000000757 glycolic acid Stitch 1.823E-5 1.885E-3 1.694E-2
8.188E-2
 3 66
44 ctd:C095105 bexarotene CTD 1.846E-5 1.885E-3 1.694E-2
8.292E-2
 5 442
45 ctd:C500085 muraglitazar CTD 1.949E-5 1.945E-3 1.748E-2
8.753E-2
 5 447
46 ctd:C016027 oxyfluorofen CTD 2.105E-5 2.055E-3 1.847E-2
9.454E-2
 2 9
47 CID000000169 6-trans-leukotriene B4 Stitch 3.625E-5 3.464E-3 3.114E-2
1.628E-1
 4 247
48 CID000442583 5,6,7-trimethoxyflavone Stitch 3.853E-5 3.606E-3 3.241E-2
1.731E-1
 2 12
49 CID010174526 2-[1-(benzyloxycarbonylamino)hexyl-hydroxy-phosphoryl]oxy-2-(3-guanidinophenyl)acetic acid Stitch 4.037E-5 3.701E-3 3.326E-2
1.813E-1
 3 86
50 CID000054221 clomoxir Stitch 5.308E-5 4.769E-3 4.286E-2
2.384E-1
 2 14
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 498 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0043459 Zellweger Syndrome DisGeNET Curated 5.756E-34 2.866E-31 1.946E-30 2.866E-31 13 31
2 C3279397 Very long chain fatty acid accumulation DisGeNET Curated 1.909E-33 3.169E-31 2.152E-30 9.508E-31 11 13
3 C0282525 Adrenoleukodystrophy, Neonatal DisGeNET Curated 1.909E-33 3.169E-31 2.152E-30 9.508E-31 11 13
4 C4023786 Elevated levels of phytanic acid DisGeNET Curated 3.339E-32 4.157E-30 2.822E-29 1.663E-29 11 15
5 C1855773 Psychomotor retardation, profound DisGeNET Curated 3.025E-31 3.013E-29 2.046E-28 1.507E-28 11 17
6 OMIN:214100 ZELLWEGER SYNDROME; ZS OMIM 6.231E-31 4.841E-29 3.286E-28 3.103E-28 10 11
7 C3553450 Profound global developmental delay DisGeNET Curated 7.777E-31 4.841E-29 3.286E-28 3.873E-28 11 18
8 C4021815 Abnormality of the palate DisGeNET Curated 7.777E-31 4.841E-29 3.286E-28 3.873E-28 11 18
9 C0282527 Infantile Refsum Disease (disorder) DisGeNET Curated 4.102E-30 2.270E-28 1.541E-27 2.043E-27 11 20
10 C1832200 Peroxisome biogenesis disorders DisGeNET Curated 8.610E-30 4.288E-28 2.911E-27 4.288E-27 11 21
11 C0240421 Muscle weakness, progressive DisGeNET Curated 1.721E-29 7.144E-28 4.850E-27 8.573E-27 11 22
12 C4021780 Abnormality of the liver DisGeNET Curated 1.721E-29 7.144E-28 4.850E-27 8.573E-27 11 22
13 C4025844 Chorioretinal abnormality DisGeNET Curated 6.087E-29 2.332E-27 1.583E-26 3.031E-26 11 24
14 C1837402 Flat occiput DisGeNET Curated 1.883E-28 6.251E-27 4.244E-26 9.377E-26 11 26
15 C4280482 Flat back of the head DisGeNET Curated 1.883E-28 6.251E-27 4.244E-26 9.377E-26 11 26
16 C1837397 Global developmental delay, severe DisGeNET Curated 4.695E-28 1.371E-26 9.306E-26 2.338E-25 12 47
17 C1854919 Severe psychomotor retardation DisGeNET Curated 4.695E-28 1.371E-26 9.306E-26 2.338E-25 12 47
18 C0344531 Embryotoxon DisGeNET Curated 5.230E-28 1.371E-26 9.306E-26 2.604E-25 11 28
19 C1859126 Stippled epiphyses DisGeNET Curated 5.230E-28 1.371E-26 9.306E-26 2.604E-25 11 28
20 C0546967 Posterior embryotoxon DisGeNET Curated 8.423E-28 2.097E-26 1.424E-25 4.195E-25 11 29
21 C1839630 Hypotonia, severe DisGeNET Curated 4.705E-27 1.116E-25 7.575E-25 2.343E-24 11 33
22 C1862095 Bilateral single transverse palmar creases DisGeNET Curated 6.953E-27 1.574E-25 1.069E-24 3.463E-24 11 34
23 C0235095 Visual field constriction DisGeNET Curated 1.459E-26 3.159E-25 2.145E-24 7.267E-24 11 36
24 C1846460 Malformed pinnae DisGeNET Curated 2.076E-26 4.307E-25 2.924E-24 1.034E-23 11 37
25 C0034194 Pyloric Stenosis DisGeNET Curated 2.921E-26 5.194E-25 3.526E-24 1.454E-23 11 38
26 C1861869 Underdeveloped supraorbital ridges DisGeNET Curated 2.921E-26 5.194E-25 3.526E-24 1.454E-23 11 38
27 C0405580 Adrenal cortical hypofunction DisGeNET Curated 2.921E-26 5.194E-25 3.526E-24 1.454E-23 11 38
28 C4020777 Underdeveloped brows DisGeNET Curated 2.921E-26 5.194E-25 3.526E-24 1.454E-23 11 38
29 C0156394 Hypertrophy of clitoris DisGeNET Curated 1.394E-25 2.393E-24 1.625E-23 6.941E-23 11 43
30 C1866134 Wide anterior fontanel DisGeNET Curated 1.858E-25 2.984E-24 2.026E-23 9.251E-23 11 44
31 C1866934 Decreased to absent deep tendon reflexes DisGeNET Curated 1.858E-25 2.984E-24 2.026E-23 9.251E-23 11 44
32 C1844947 Death in early childhood DisGeNET Curated 7.370E-25 1.112E-23 7.551E-23 3.670E-22 12 82
33 C1858430 Death in infancy DisGeNET Curated 7.370E-25 1.112E-23 7.551E-23 3.670E-22 12 82
34 C0521719 Clouding of corneal stroma DisGeNET Curated 1.151E-24 1.686E-23 1.144E-22 5.731E-22 11 51
35 C1853241 Flat face DisGeNET Curated 1.459E-24 2.076E-23 1.409E-22 7.266E-22 11 52
36 C0010038 Corneal Opacity DisGeNET Curated 1.841E-24 2.546E-23 1.729E-22 9.166E-22 11 53
37 C3714581 Multicystic Dysplastic Kidney DisGeNET Curated 2.887E-24 3.886E-23 2.638E-22 1.438E-21 11 55
38 C4280567 Abnormal skeletal development DisGeNET Curated 8.256E-24 1.082E-22 7.345E-22 4.111E-21 11 60
39 C1857121 Neurodevelopmental regression DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
40 C1855996 Psychomotor regression beginning in infancy DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
41 C1859678 Mental deterioration in childhood DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
42 C1850493 Psychomotor regression, progressive DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
43 C1855019 Psychomotor regression DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
44 C1855009 Psychomotor regression in infants DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
45 C1836550 Loss of developmental milestones DisGeNET Curated 1.195E-23 1.322E-22 8.978E-22 5.951E-21 12 102
46 C0151611 Electroencephalogram abnormal DisGeNET Curated 1.352E-23 1.464E-22 9.938E-22 6.734E-21 12 103
47 C0001403 Addison Disease DisGeNET Curated 2.582E-23 2.736E-22 1.857E-21 1.286E-20 11 66
48 C1836830 Developmental regression DisGeNET Curated 2.766E-23 2.870E-22 1.948E-21 1.378E-20 12 109
49 C0233315 Premature birth of newborn DisGeNET Curated 3.088E-23 3.139E-22 2.131E-21 1.538E-20 11 67
50 C1837249 Malformations of Cortical Development, Group II DisGeNET Curated 6.145E-23 6.121E-22 4.155E-21 3.060E-20 11 71
Show 45 more annotations