Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc144_28, positive side

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1: GO: Molecular Function [Display Chart] 28 input genes in category / 78 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 8.474E-25 6.610E-23 3.265E-22 6.610E-23 18 357
2 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 1.094E-22 4.265E-21 2.107E-20 8.531E-21 17 365
3 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 2.087E-22 5.426E-21 2.681E-20 1.628E-20 17 379
4 GO:0000987 proximal promoter sequence-specific DNA binding 4.826E-22 9.411E-21 4.649E-20 3.764E-20 17 398
5 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 2.898E-21 4.521E-20 2.234E-19 2.261E-19 15 259
6 GO:0035497 cAMP response element binding 1.095E-14 1.424E-13 7.035E-13 8.544E-13 6 13
7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 8.833E-9 9.843E-8 4.863E-7 6.890E-7 6 104
8 GO:0008140 cAMP response element binding protein binding 3.605E-7 3.515E-6 1.736E-5 2.812E-5 3 10
9 GO:0001085 RNA polymerase II transcription factor binding 8.122E-7 7.039E-6 3.478E-5 6.335E-5 5 118
10 GO:0001047 core promoter binding 4.116E-6 3.210E-5 1.586E-4 3.210E-4 5 164
11 GO:0003713 transcription coactivator activity 5.543E-6 3.931E-5 1.942E-4 4.324E-4 6 310
12 GO:0001158 enhancer sequence-specific DNA binding 1.080E-5 7.019E-5 3.468E-4 8.423E-4 4 93
13 GO:0035035 histone acetyltransferase binding 1.195E-5 7.172E-5 3.543E-4 9.324E-4 3 30
14 GO:0035326 enhancer binding 1.813E-5 1.010E-4 4.990E-4 1.414E-3 4 106
15 GO:0042826 histone deacetylase binding 2.415E-5 1.147E-4 5.666E-4 1.884E-3 4 114
16 GO:0001102 RNA polymerase II activating transcription factor binding 2.464E-5 1.147E-4 5.666E-4 1.922E-3 3 38
17 GO:0001046 core promoter sequence-specific DNA binding 2.500E-5 1.147E-4 5.666E-4 1.950E-3 4 115
18 GO:0033613 activating transcription factor binding 1.027E-4 4.451E-4 2.199E-3 8.012E-3 3 61
19 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 1.615E-4 6.630E-4 3.275E-3 1.260E-2 3 71
20 GO:0071837 HMG box domain binding 5.387E-4 2.101E-3 1.038E-2 4.202E-2 2 23
21 GO:0070412 R-SMAD binding 5.871E-4 2.181E-3 1.077E-2 4.579E-2 2 24
22 GO:0044374 sequence-specific DNA binding, bending 1.500E-3 4.876E-3 2.409E-2
1.170E-1
 1 1
23 GO:1990763 arrestin family protein binding 1.500E-3 4.876E-3 2.409E-2
1.170E-1
 1 1
24 GO:0044377 RNA polymerase II proximal promoter sequence-specific DNA binding, bending 1.500E-3 4.876E-3 2.409E-2
1.170E-1
 1 1
25 GO:0004402 histone acetyltransferase activity 3.642E-3 1.128E-2
5.575E-2
2.840E-1
 2 60
26 GO:0061733 peptide-lysine-N-acetyltransferase activity 3.762E-3 1.128E-2
5.575E-2
2.934E-1
 2 61
27 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4.389E-3 1.268E-2
6.264E-2
3.423E-1
 2 66
28 GO:0034212 peptide N-acetyltransferase activity 4.787E-3 1.333E-2
6.588E-2
3.734E-1
 2 69
29 GO:0046332 SMAD binding 5.926E-3 1.594E-2
7.874E-2
4.622E-1
 2 77
30 GO:0035258 steroid hormone receptor binding 7.844E-3 2.027E-2
1.001E-1
6.118E-1
 2 89
31 GO:0044389 ubiquitin-like protein ligase binding 8.056E-3 2.027E-2
1.001E-1
6.284E-1
 3 277
32 GO:0031726 CCR1 chemokine receptor binding 8.970E-3 2.120E-2
1.047E-1
6.997E-1
 1 6
33 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor 8.970E-3 2.120E-2
1.047E-1
6.997E-1
 1 6
34 GO:0008080 N-acetyltransferase activity 1.097E-2 2.445E-2
1.208E-1
8.559E-1
 2 106
35 GO:0031072 heat shock protein binding 1.097E-2 2.445E-2
1.208E-1
8.559E-1
 2 106
36 GO:0001078 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific 1.261E-2 2.732E-2
1.349E-1
9.834E-1
 2 114
37 GO:0001013 RNA polymerase I regulatory region DNA binding 1.343E-2 2.830E-2
1.398E-1
1.000E0
 1 9
38 GO:0016410 N-acyltransferase activity 1.434E-2 2.913E-2
1.439E-1
1.000E0
 2 122
39 GO:0016407 acetyltransferase activity 1.456E-2 2.913E-2
1.439E-1
1.000E0
 2 123
40 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1.786E-2 3.398E-2
1.679E-1
1.000E0
 1 12
41 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1.786E-2 3.398E-2
1.679E-1
1.000E0
 1 12
42 GO:0043522 leucine zipper domain binding 1.934E-2 3.591E-2
1.774E-1
1.000E0
 1 13
43 GO:0035257 nuclear hormone receptor binding 2.414E-2 4.380E-2
2.164E-1
1.000E0
 2 161
44 GO:0035259 glucocorticoid receptor binding 2.814E-2 4.971E-2
2.456E-1
1.000E0
 1 19
45 GO:0030275 LRR domain binding 2.960E-2 4.971E-2
2.456E-1
1.000E0
 1 20
46 GO:0008301 DNA binding, bending 2.960E-2 4.971E-2
2.456E-1
1.000E0
 1 20
47 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3.029E-2 4.971E-2
2.456E-1
1.000E0
 2 182
48 GO:0051427 hormone receptor binding 3.059E-2 4.971E-2
2.456E-1
1.000E0
 2 183
Show 43 more annotations

2: GO: Biological Process [Display Chart] 28 input genes in category / 1111 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1.109E-14 1.232E-11 9.351E-11 1.232E-11 6 13
2 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 8.601E-13 4.778E-10 3.627E-9 9.555E-10 6 24
3 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 4.516E-12 1.672E-9 1.269E-8 5.017E-9 7 64
4 GO:0043620 regulation of DNA-templated transcription in response to stress 8.662E-12 2.406E-9 1.826E-8 9.624E-9 7 70
5 GO:0002573 myeloid leukocyte differentiation 7.060E-10 1.569E-7 1.191E-6 7.844E-7 8 215
6 GO:0030099 myeloid cell differentiation 3.282E-9 5.833E-7 4.427E-6 3.646E-6 9 388
7 GO:0034976 response to endoplasmic reticulum stress 3.675E-9 5.833E-7 4.427E-6 4.083E-6 8 265
8 GO:0006984 ER-nucleus signaling pathway 4.876E-9 6.772E-7 5.140E-6 5.417E-6 5 43
9 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response 1.216E-8 1.501E-6 1.140E-5 1.351E-5 3 4
10 GO:0045444 fat cell differentiation 3.266E-8 3.456E-6 2.623E-5 3.629E-5 7 225
11 GO:0030968 endoplasmic reticulum unfolded protein response 3.422E-8 3.456E-6 2.623E-5 3.802E-5 6 130
12 GO:0034620 cellular response to unfolded protein 3.922E-8 3.631E-6 2.757E-5 4.358E-5 6 133
13 GO:0048511 rhythmic process 4.546E-8 3.885E-6 2.949E-5 5.051E-5 8 366
14 GO:0035967 cellular response to topologically incorrect protein 5.560E-8 4.412E-6 3.349E-5 6.177E-5 6 141
15 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 8.163E-8 5.807E-6 4.408E-5 9.069E-5 4 28
16 GO:0071248 cellular response to metal ion 8.363E-8 5.807E-6 4.408E-5 9.291E-5 6 151
17 GO:0007611 learning or memory 1.166E-7 7.620E-6 5.784E-5 1.295E-4 7 271
18 GO:0006986 response to unfolded protein 1.938E-7 1.196E-5 9.082E-5 2.154E-4 6 174
19 GO:0071241 cellular response to inorganic substance 2.074E-7 1.213E-5 9.205E-5 2.304E-4 6 176
20 GO:0050890 cognition 2.487E-7 1.382E-5 1.049E-4 2.763E-4 7 303
21 GO:0035966 response to topologically incorrect protein 2.696E-7 1.426E-5 1.083E-4 2.995E-4 6 184
22 GO:0036500 ATF6-mediated unfolded protein response 3.627E-7 1.832E-5 1.390E-4 4.029E-4 3 10
23 GO:0051591 response to cAMP 5.529E-7 2.671E-5 2.027E-4 6.142E-4 5 109
24 GO:0031668 cellular response to extracellular stimulus 6.197E-7 2.869E-5 2.178E-4 6.885E-4 6 212
25 GO:0007623 circadian rhythm 6.548E-7 2.910E-5 2.209E-4 7.274E-4 6 214
26 GO:0010038 response to metal ion 8.551E-7 3.654E-5 2.774E-4 9.501E-4 7 364
27 GO:0002761 regulation of myeloid leukocyte differentiation 1.049E-6 4.317E-5 3.277E-4 1.166E-3 5 124
28 GO:0045600 positive regulation of fat cell differentiation 1.423E-6 5.645E-5 4.285E-4 1.581E-3 4 56
29 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance 2.180E-6 8.351E-5 6.339E-4 2.422E-3 2 2
30 GO:0046683 response to organophosphorus 2.350E-6 8.702E-5 6.605E-4 2.611E-3 5 146
31 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 2.441E-6 8.747E-5 6.640E-4 2.712E-3 4 64
32 GO:1902105 regulation of leukocyte differentiation 2.815E-6 9.773E-5 7.418E-4 3.127E-3 6 275
33 GO:0045669 positive regulation of osteoblast differentiation 3.116E-6 1.049E-4 7.962E-4 3.461E-3 4 68
34 GO:0071496 cellular response to external stimulus 3.823E-6 1.242E-4 9.431E-4 4.248E-3 6 290
35 GO:0007612 learning 3.914E-6 1.242E-4 9.431E-4 4.349E-3 5 162
36 GO:0045670 regulation of osteoclast differentiation 4.142E-6 1.278E-4 9.704E-4 4.602E-3 4 73
37 GO:0001889 liver development 4.814E-6 1.445E-4 1.097E-3 5.348E-3 5 169
38 GO:0014074 response to purine-containing compound 5.099E-6 1.491E-4 1.132E-3 5.665E-3 5 171
39 GO:0061008 hepaticobiliary system development 5.246E-6 1.494E-4 1.134E-3 5.828E-3 5 172
40 GO:0061614 pri-miRNA transcription by RNA polymerase II 6.847E-6 1.902E-4 1.444E-3 7.607E-3 3 25
41 GO:2000144 positive regulation of DNA-templated transcription, initiation 7.733E-6 2.095E-4 1.591E-3 8.591E-3 3 26
42 GO:0032496 response to lipopolysaccharide 9.831E-6 2.600E-4 1.974E-3 1.092E-2 6 342
43 GO:0045637 regulation of myeloid cell differentiation 1.231E-5 3.181E-4 2.414E-3 1.368E-2 5 205
44 GO:0002237 response to molecule of bacterial origin 1.275E-5 3.219E-4 2.444E-3 1.416E-2 6 358
45 GO:0045778 positive regulation of ossification 1.395E-5 3.444E-4 2.614E-3 1.550E-2 4 99
46 GO:0030316 osteoclast differentiation 1.510E-5 3.633E-4 2.758E-3 1.677E-2 4 101
47 GO:1903706 regulation of hemopoiesis 1.537E-5 3.633E-4 2.758E-3 1.708E-2 6 370
48 GO:2000142 regulation of DNA-templated transcription, initiation 1.611E-5 3.729E-4 2.831E-3 1.790E-2 3 33
49 GO:0042089 cytokine biosynthetic process 2.978E-5 6.753E-4 5.126E-3 3.309E-2 4 120
50 GO:0001819 positive regulation of cytokine production 3.057E-5 6.790E-4 5.154E-3 3.396E-2 6 418
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 28 input genes in category / 67 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005667 transcription factor complex 1.916E-12 1.284E-10 6.150E-10 1.284E-10 11 368
2 GO:0090575 RNA polymerase II transcription factor complex 4.095E-7 1.372E-5 6.569E-5 2.743E-5 5 105
3 GO:0044798 nuclear transcription factor complex 1.375E-6 2.788E-5 1.335E-4 9.212E-5 5 134
4 GO:1990589 ATF4-CREB1 transcription factor complex 2.081E-6 2.788E-5 1.335E-4 1.394E-4 2 2
5 GO:1990590 ATF1-ATF4 transcription factor complex 2.081E-6 2.788E-5 1.335E-4 1.394E-4 2 2
6 GO:0036488 CHOP-C/EBP complex 6.237E-6 6.965E-5 3.336E-4 4.179E-4 2 3
7 GO:0034399 nuclear periphery 4.318E-5 3.830E-4 1.834E-3 2.893E-3 4 135
8 GO:0030176 integral component of endoplasmic reticulum membrane 4.573E-5 3.830E-4 1.834E-3 3.064E-3 4 137
9 GO:0031227 intrinsic component of endoplasmic reticulum membrane 5.260E-5 3.916E-4 1.876E-3 3.524E-3 4 142
10 GO:0000790 nuclear chromatin 9.805E-5 6.570E-4 3.146E-3 6.570E-3 5 324
11 GO:0000785 chromatin 6.446E-4 3.926E-3 1.880E-2 4.319E-2 5 487
12 GO:0031301 integral component of organelle membrane 7.354E-4 4.106E-3 1.967E-2 4.927E-2 4 283
13 GO:0031300 intrinsic component of organelle membrane 8.695E-4 4.223E-3 2.023E-2
5.826E-2
 4 296
14 GO:0005719 nuclear euchromatin 8.824E-4 4.223E-3 2.023E-2
5.912E-2
 2 30
15 GO:0000791 euchromatin 1.568E-3 7.004E-3 3.354E-2
1.051E-1
 2 40
16 GO:1990037 Lewy body core 2.936E-3 1.093E-2
5.234E-2
1.967E-1
 1 2
17 GO:1990617 CHOP-ATF4 complex 2.936E-3 1.093E-2
5.234E-2
1.967E-1
 1 2
18 GO:1990622 CHOP-ATF3 complex 2.936E-3 1.093E-2
5.234E-2
1.967E-1
 1 2
19 GO:0035189 Rb-E2F complex 5.863E-3 2.068E-2
9.903E-2
3.928E-1
 1 4
20 GO:0097413 Lewy body 7.324E-3 2.454E-2
1.175E-1
4.907E-1
 1 5
21 GO:0000125 PCAF complex 8.783E-3 2.802E-2
1.342E-1
5.884E-1
 1 6
22 GO:0016363 nuclear matrix 1.035E-2 3.152E-2
1.509E-1
6.934E-1
 2 105
23 GO:0042788 polysomal ribosome 1.169E-2 3.406E-2
1.631E-1
7.835E-1
 1 8
Show 18 more annotations

4: Human Phenotype [Display Chart] 9 input genes in category / 468 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 26 input genes in category / 1241 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001783 decreased white adipose tissue amount 2.389E-6 2.965E-3 2.283E-2 2.965E-3 5 89
2 MP:0000609 abnormal liver physiology 6.136E-6 3.807E-3 2.932E-2 7.614E-3 8 425
3 MP:0002139 abnormal hepatobiliary system physiology 1.047E-5 4.331E-3 3.336E-2 1.299E-2 8 457
4 MP:0013376 abnormal sebocyte differentiation 1.816E-5 5.463E-3 4.207E-2 2.254E-2 2 3
5 MP:0006410 abnormal common myeloid progenitor cell morphology 2.201E-5 5.463E-3 4.207E-2 2.731E-2 5 140
6 MP:0003887 increased hepatocyte apoptosis 2.861E-5 5.918E-3 4.558E-2 3.551E-2 4 72
7 MP:0010080 abnormal hepatocyte physiology 3.484E-5 6.177E-3 4.757E-2 4.324E-2 5 154
8 MP:0003204 decreased neuron apoptosis 4.782E-5 7.419E-3
5.713E-2
5.935E-2
 4 82
9 MP:0004001 decreased hepatocyte proliferation 7.294E-5 8.833E-3
6.802E-2
9.052E-2
 3 33
10 MP:0005334 abnormal fat pad morphology 8.233E-5 8.833E-3
6.802E-2
1.022E-1
 6 302
11 MP:0003427 parakeratosis 8.721E-5 8.833E-3
6.802E-2
1.082E-1
 3 35
12 MP:0003695 delayed blastocyst hatching from the zona pellucida 9.038E-5 8.833E-3
6.802E-2
1.122E-1
 2 6
13 MP:0002891 increased insulin sensitivity 9.253E-5 8.833E-3
6.802E-2
1.148E-1
 5 189
14 MP:0002658 abnormal liver regeneration 1.032E-4 9.146E-3
7.044E-2
1.281E-1
 3 37
15 MP:0001345 Meibomian gland atrophy 1.263E-4 9.530E-3
7.339E-2
1.568E-1
 2 7
16 MP:0010688 hair follicle outer root sheath hyperplasia 1.263E-4 9.530E-3
7.339E-2
1.568E-1
 2 7
17 MP:0002051 increased skin papilloma incidence 1.305E-4 9.530E-3
7.339E-2
1.620E-1
 3 40
18 MP:0011090 perinatal lethality, incomplete penetrance 1.388E-4 9.570E-3
7.370E-2
1.723E-1
 6 332
19 MP:0001219 thick epidermis 1.910E-4 1.197E-2
9.218E-2
2.370E-1
 4 117
20 MP:0000601 small liver 1.971E-4 1.197E-2
9.218E-2
2.447E-1
 5 222
21 MP:0009560 absent epidermis stratum granulosum 2.159E-4 1.197E-2
9.218E-2
2.679E-1
 2 9
22 MP:0009115 abnormal fat cell morphology 2.187E-4 1.197E-2
9.218E-2
2.714E-1
 5 227
23 MP:0020040 decreased bone ossification 2.255E-4 1.197E-2
9.218E-2
2.799E-1
 3 48
24 MP:0005666 abnormal adipose tissue physiology 2.315E-4 1.197E-2
9.218E-2
2.873E-1
 4 123
25 MP:0001781 abnormal white adipose tissue amount 3.117E-4 1.531E-2
1.179E-1
3.868E-1
 5 245
26 MP:0001241 absent epidermis stratum corneum 3.288E-4 1.531E-2
1.179E-1
4.081E-1
 2 11
27 MP:0011088 neonatal lethality, incomplete penetrance 3.330E-4 1.531E-2
1.179E-1
4.133E-1
 6 390
28 MP:0008942 abnormal induced cell death 3.748E-4 1.630E-2
1.255E-1
4.652E-1
 5 255
29 MP:0010682 abnormal hair follicle infundibulum morphology 3.940E-4 1.630E-2
1.255E-1
4.889E-1
 2 12
30 MP:0002992 abnormal sebaceous lipid secretion 3.940E-4 1.630E-2
1.255E-1
4.889E-1
 2 12
31 MP:0002014 increased papilloma incidence 4.162E-4 1.646E-2
1.268E-1
5.165E-1
 3 59
32 MP:0002412 increased susceptibility to bacterial infection 4.246E-4 1.646E-2
1.268E-1
5.269E-1
 5 262
33 MP:0011699 abnormal brown adipose tissue thermogenesis 4.649E-4 1.648E-2
1.270E-1
5.769E-1
 2 13
34 MP:0013375 abnormal sebocyte morphology 4.649E-4 1.648E-2
1.270E-1
5.769E-1
 2 13
35 MP:0000239 absent common myeloid progenitor cells 4.649E-4 1.648E-2
1.270E-1
5.769E-1
 2 13
36 MP:0003202 abnormal neuron apoptosis 4.956E-4 1.694E-2
1.304E-1
6.151E-1
 5 271
37 MP:0003383 abnormal gluconeogenesis 5.050E-4 1.694E-2
1.304E-1
6.267E-1
 3 63
38 MP:0009289 decreased epididymal fat pad weight 5.290E-4 1.727E-2
1.330E-1
6.564E-1
 3 64
39 MP:0009134 abnormal brown fat lipid droplet number 6.239E-4 1.909E-2
1.470E-1
7.743E-1
 2 15
40 MP:0000606 decreased hepatocyte number 6.239E-4 1.909E-2
1.470E-1
7.743E-1
 2 15
41 MP:0005466 abnormal T-helper 2 physiology 6.320E-4 1.909E-2
1.470E-1
7.844E-1
 3 68
42 MP:0001337 dry eyes 7.119E-4 1.909E-2
1.470E-1
8.835E-1
 2 16
43 MP:0002717 abnormal male preputial gland morphology 7.119E-4 1.909E-2
1.470E-1
8.835E-1
 2 16
44 MP:0008735 increased susceptibility to endotoxin shock 7.172E-4 1.909E-2
1.470E-1
8.901E-1
 3 71
45 MP:0009582 abnormal keratinocyte proliferation 7.172E-4 1.909E-2
1.470E-1
8.901E-1
 3 71
46 MP:0000600 liver hypoplasia 7.172E-4 1.909E-2
1.470E-1
8.901E-1
 3 71
47 MP:0001469 abnormal contextual conditioning behavior 7.230E-4 1.909E-2
1.470E-1
8.972E-1
 4 166
48 MP:0010639 altered tumor pathology 7.752E-4 2.000E-2
1.540E-1
9.621E-1
 5 299
49 MP:0000175 absent bone marrow cell 8.056E-4 2.000E-2
1.540E-1
9.998E-1
 2 17
50 MP:0009102 abnormal glans penis morphology 8.056E-4 2.000E-2
1.540E-1
9.998E-1
 2 17
Show 45 more annotations

6: Domain [Display Chart] 28 input genes in category / 69 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00338 BRLZ SMART 4.833E-57 1.963E-55 9.459E-55 3.334E-55 23 52
2 PS00036 BZIP BASIC PROSITE 8.535E-57 1.963E-55 9.459E-55 5.889E-55 23 53
3 PS50217 BZIP PROSITE 8.535E-57 1.963E-55 9.459E-55 5.889E-55 23 53
4 IPR004827 bZIP InterPro 1.486E-56 2.564E-55 1.236E-54 1.026E-54 23 54
5 IPR008917 TF DNA-bd InterPro 2.804E-41 3.869E-40 1.864E-39 1.935E-39 17 37
6 PF00170 bZIP 1 Pfam 6.062E-39 6.971E-38 3.359E-37 4.183E-37 16 34
7 PF07716 bZIP 2 Pfam 1.993E-19 1.965E-18 9.466E-18 1.375E-17 8 17
8 IPR031106 C/EBP InterPro 5.112E-15 4.409E-14 2.125E-13 3.527E-13 5 5
9 IPR016468 C/EBP chordates InterPro 3.990E-12 3.059E-11 1.474E-10 2.753E-10 4 4
10 IPR000837 AP-1 InterPro 5.002E-10 3.451E-9 1.663E-8 3.451E-8 4 9
11 PF02173 pKID Pfam 2.990E-9 1.587E-8 7.646E-8 2.063E-7 3 3
12 IPR003102 Coactivator CBP pKID InterPro 2.990E-9 1.587E-8 7.646E-8 2.063E-7 3 3
13 PS50953 KID PROSITE 2.990E-9 1.587E-8 7.646E-8 2.063E-7 3 3
14 IPR001630 Leuzip CREB InterPro 1.195E-8 5.888E-8 2.837E-7 8.243E-7 3 4
15 1.10.880.10 - Gene3D 1.652E-6 7.601E-6 3.663E-5 1.140E-4 3 16
16 IPR002112 Leuzip Jun InterPro 6.456E-6 2.345E-5 1.130E-4 4.455E-4 2 3
17 IPR005643 JNK InterPro 6.456E-6 2.345E-5 1.130E-4 4.455E-4 2 3
18 IPR016378 TF CRE-BP1-typ InterPro 6.456E-6 2.345E-5 1.130E-4 4.455E-4 2 3
19 PF03957 Jun Pfam 6.456E-6 2.345E-5 1.130E-4 4.455E-4 2 3
20 IPR033527 NMI InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
21 IPR029801 ATF6A InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
22 IPR029836 ATF-2 InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
23 IPR029816 c-Fos/v-Fos InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
24 IPR029811 ATF4 InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
25 IPR015558 C Jun/v-Jun InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
26 IPR029855 ATF-5 InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
27 IPR029808 Luman InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
28 IPR029812 ATF3 InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
29 IPR029823 JunD InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
30 IPR029820 BATF InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
31 IPR029809 ATF6B InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
32 IPR029825 ATF1 InterPro 1.495E-3 3.223E-3 1.553E-2
1.031E-1
 1 1
33 IPR009938 Nmi/IFP35 N InterPro 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
34 IPR009909 Nmi/IFP35 dom InterPro 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
35 PF17045 CEP63 Pfam 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
36 PF07292 NID Pfam 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
37 IPR009464 PCAF N InterPro 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
38 IPR031470 Cep63/Deup1 N InterPro 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
39 PF06466 PCAF N Pfam 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
40 IPR016376 Hist acetylase PCAF InterPro 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
41 PF07334 IFP 35 N Pfam 2.987E-3 5.027E-3 2.422E-2
2.061E-1
 1 2
42 IPR005612 CCAAT-binding factor InterPro 4.477E-3 7.184E-3 3.462E-2
3.089E-1
 1 3
43 PF03914 CBF Pfam 4.477E-3 7.184E-3 3.462E-2
3.089E-1
 1 3
44 PF08383 Maf N Pfam 5.965E-3 8.948E-3 4.312E-2
4.116E-1
 1 4
45 IPR013592 Maf TF N InterPro 5.965E-3 8.948E-3 4.312E-2
4.116E-1
 1 4
46 IPR006548 ELAD HUD SF InterPro 5.965E-3 8.948E-3 4.312E-2
4.116E-1
 1 4
47 IPR024874 Transciption factor Maf fam InterPro 1.042E-2 1.529E-2
7.369E-2
7.187E-1
 1 7
48 IPR002343 Hud Sxl RNA InterPro 1.485E-2 2.135E-2
1.029E-1
1.000E0
 1 10
49 IPR004826 bZIP Maf InterPro 1.926E-2 2.658E-2
1.281E-1
1.000E0
 1 13
50 PF03131 bZIP Maf Pfam 1.926E-2 2.658E-2
1.281E-1
1.000E0
 1 13
Show 45 more annotations

7: Pathway [Display Chart] 27 input genes in category / 356 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00006 Apoptosis signaling pathway PantherDB 4.814E-13 1.714E-10 1.106E-9 1.714E-10 9 102
2 373901 HTLV-I infection BioSystems: KEGG 2.186E-12 3.892E-10 2.512E-9 7.784E-10 11 256
3 812256 TNF signaling pathway BioSystems: KEGG 4.775E-11 5.666E-9 3.656E-8 1.700E-8 8 108
4 547607 Amphetamine addiction BioSystems: KEGG 8.602E-11 6.350E-9 4.098E-8 3.062E-8 7 68
5 138012 Signaling mediated by p38-alpha and p38-beta BioSystems: Pathway Interaction Database 8.918E-11 6.350E-9 4.098E-8 3.175E-8 6 35
6 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 2.107E-10 1.250E-8 8.067E-8 7.500E-8 7 77
7 546258 Cocaine addiction BioSystems: KEGG 7.529E-10 3.829E-8 2.471E-7 2.680E-7 6 49
8 799177 Estrogen signaling pathway BioSystems: KEGG 1.177E-9 5.236E-8 3.379E-7 4.189E-7 7 98
9 138006 ATF-2 transcription factor network BioSystems: Pathway Interaction Database 1.547E-9 6.120E-8 3.950E-7 5.508E-7 6 55
10 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 1.730E-9 6.160E-8 3.976E-7 6.160E-7 6 56
11 1269214 MAPK targets/ Nuclear events mediated by MAP kinases BioSystems: REACTOME 5.300E-9 1.715E-7 1.107E-6 1.887E-6 5 31
12 M18899 Repression of Pain Sensation by the Transcriptional Regulator DREAM MSigDB C2 BIOCARTA (v6.0) 1.730E-8 4.570E-7 2.949E-6 6.159E-6 4 14
13 694606 Hepatitis B BioSystems: KEGG 1.751E-8 4.570E-7 2.949E-6 6.232E-6 7 144
14 1272485 Aldosterone synthesis and secretion BioSystems: KEGG 1.797E-8 4.570E-7 2.949E-6 6.398E-6 6 82
15 658418 Viral carcinogenesis BioSystems: KEGG 1.739E-7 4.128E-6 2.664E-5 6.191E-5 7 201
16 1269211 MAP kinase activation in TLR cascade BioSystems: REACTOME 2.265E-7 5.040E-6 3.253E-5 8.064E-5 5 64
17 469199 Dopaminergic synapse BioSystems: KEGG 2.854E-7 5.884E-6 3.797E-5 1.016E-4 6 130
18 M7871 Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v6.0) 2.975E-7 5.884E-6 3.797E-5 1.059E-4 4 27
19 835410 Thyroid hormone synthesis BioSystems: KEGG 4.716E-7 8.836E-6 5.702E-5 1.679E-4 5 74
20 908257 Adrenergic signaling in cardiomyocytes BioSystems: KEGG 5.226E-7 9.302E-6 6.003E-5 1.860E-4 6 144
21 1269206 Toll Like Receptor 10 (TLR10) Cascade BioSystems: REACTOME 8.905E-7 1.378E-5 8.896E-5 3.170E-4 5 84
22 1269226 Toll Like Receptor 5 (TLR5) Cascade BioSystems: REACTOME 8.905E-7 1.378E-5 8.896E-5 3.170E-4 5 84
23 1269207 MyD88 cascade initiated on plasma membrane BioSystems: REACTOME 8.905E-7 1.378E-5 8.896E-5 3.170E-4 5 84
24 777534 Insulin secretion BioSystems: KEGG 9.448E-7 1.401E-5 9.044E-5 3.363E-4 5 85
25 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.061E-6 1.480E-5 9.548E-5 3.778E-4 5 87
26 1269218 Activation of the AP-1 family of transcription factors BioSystems: REACTOME 1.081E-6 1.480E-5 9.548E-5 3.847E-4 3 10
27 1319989 Longevity regulating pathway BioSystems: KEGG 1.189E-6 1.567E-5 1.011E-4 4.231E-4 5 89
28 1269229 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation BioSystems: REACTOME 1.328E-6 1.626E-5 1.049E-4 4.727E-4 5 91
29 1269228 MyD88 dependent cascade initiated on endosome BioSystems: REACTOME 1.479E-6 1.626E-5 1.049E-4 5.267E-4 5 93
30 1474301 IL-17 signaling pathway BioSystems: KEGG 1.479E-6 1.626E-5 1.049E-4 5.267E-4 5 93
31 1269227 Toll Like Receptor 7/8 (TLR7/8) Cascade BioSystems: REACTOME 1.479E-6 1.626E-5 1.049E-4 5.267E-4 5 93
32 1268758 ATF6 (ATF6-alpha) activates chaperone genes BioSystems: REACTOME 1.484E-6 1.626E-5 1.049E-4 5.282E-4 3 11
33 1269240 Toll Like Receptor TLR6:TLR2 Cascade BioSystems: REACTOME 1.644E-6 1.626E-5 1.049E-4 5.854E-4 5 95
34 1269237 MyD88:Mal cascade initiated on plasma membrane BioSystems: REACTOME 1.644E-6 1.626E-5 1.049E-4 5.854E-4 5 95
35 1269238 Toll Like Receptor 2 (TLR2) Cascade BioSystems: REACTOME 1.644E-6 1.626E-5 1.049E-4 5.854E-4 5 95
36 1269239 Toll Like Receptor TLR1:TLR2 Cascade BioSystems: REACTOME 1.644E-6 1.626E-5 1.049E-4 5.854E-4 5 95
37 1269233 Toll Like Receptor 9 (TLR9) Cascade BioSystems: REACTOME 1.824E-6 1.732E-5 1.118E-4 6.492E-4 5 97
38 1269220 MyD88-independent TLR3/TLR4 cascade BioSystems: REACTOME 2.018E-6 1.732E-5 1.118E-4 7.184E-4 5 99
39 1269221 TRIF-mediated TLR3/TLR4 signaling BioSystems: REACTOME 2.018E-6 1.732E-5 1.118E-4 7.184E-4 5 99
40 1269219 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 2.018E-6 1.732E-5 1.118E-4 7.184E-4 5 99
41 137979 FOXA1 transcription factor network BioSystems: Pathway Interaction Database 2.043E-6 1.732E-5 1.118E-4 7.274E-4 4 43
42 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 2.043E-6 1.732E-5 1.118E-4 7.274E-4 4 43
43 137911 FOXA2 and FOXA3 transcription factor networks BioSystems: Pathway Interaction Database 2.244E-6 1.858E-5 1.199E-4 7.989E-4 4 44
44 138057 ErbB1 downstream signaling BioSystems: Pathway Interaction Database 2.340E-6 1.893E-5 1.222E-4 8.329E-4 5 102
45 M2579 Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v6.0) 2.459E-6 1.942E-5 1.253E-4 8.756E-4 4 45
46 1268757 ATF6 (ATF6-alpha) activates chaperones BioSystems: REACTOME 2.564E-6 1.942E-5 1.253E-4 9.129E-4 3 13
47 M14339 Oxidative Stress Induced Gene Expression Via Nrf2 MSigDB C2 BIOCARTA (v6.0) 2.564E-6 1.942E-5 1.253E-4 9.129E-4 3 13
48 1269236 Activated TLR4 signalling BioSystems: REACTOME 4.229E-6 3.136E-5 2.024E-4 1.506E-3 5 115
49 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 6.621E-6 4.810E-5 3.104E-4 2.357E-3 5 126
50 193147 Osteoclast differentiation BioSystems: KEGG 7.714E-6 5.493E-5 3.545E-4 2.746E-3 5 130
Show 45 more annotations

8: Pubmed [Display Chart] 28 input genes in category / 8098 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20102225 Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Pubmed 2.560E-55 2.073E-51 1.985E-50 2.073E-51 19 32
2 23661758 Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Pubmed 1.549E-46 6.271E-43 6.005E-42 1.254E-42 17 37
3 12805554 Comprehensive identification of human bZIP interactions with coiled-coil arrays. Pubmed 2.040E-33 5.507E-30 5.273E-29 1.652E-29 12 23
4 9858769 Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Pubmed 1.206E-21 2.442E-18 2.339E-17 9.770E-18 8 18
5 2516827 Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Pubmed 8.743E-20 1.416E-16 1.356E-15 7.080E-16 6 6
6 24952347 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1. Pubmed 1.557E-18 2.102E-15 2.013E-14 1.261E-14 9 74
7 20398657 The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor. Pubmed 1.309E-16 1.306E-13 1.251E-12 1.060E-12 7 31
8 1827203 Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Pubmed 1.452E-16 1.306E-13 1.251E-12 1.175E-12 5 5
9 10319019 The C/EBP family of transcription factors in the liver and other organs. Pubmed 1.452E-16 1.306E-13 1.251E-12 1.175E-12 5 5
10 8570175 B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Pubmed 8.705E-16 6.409E-13 6.137E-12 7.049E-12 5 6
11 9001238 Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins. Pubmed 8.705E-16 6.409E-13 6.137E-12 7.049E-12 5 6
12 8628277 Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. Pubmed 8.117E-15 4.695E-12 4.496E-11 6.573E-11 5 8
13 10567391 The role of human MBF1 as a transcriptional coactivator. Pubmed 8.117E-15 4.695E-12 4.496E-11 6.573E-11 5 8
14 26747248 CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Pubmed 8.117E-15 4.695E-12 4.496E-11 6.573E-11 5 8
15 23475960 c-Jun is required for the specification of joint cell fates. Pubmed 4.106E-14 2.217E-11 2.123E-10 3.325E-10 6 29
16 12220541 Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Pubmed 6.686E-14 3.384E-11 3.241E-10 5.414E-10 5 11
17 1638120 Mechanisms of liver-specific gene expression. Pubmed 2.310E-13 9.844E-11 9.428E-10 1.870E-9 4 4
18 1884998 A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Pubmed 2.310E-13 9.844E-11 9.428E-10 1.870E-9 4 4
19 20511396 In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo. Pubmed 2.310E-13 9.844E-11 9.428E-10 1.870E-9 4 4
20 11431474 Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA. Pubmed 1.154E-12 4.249E-10 4.069E-9 9.348E-9 4 5
21 16313514 Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons. Pubmed 1.154E-12 4.249E-10 4.069E-9 9.348E-9 4 5
22 1371974 cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. Pubmed 1.154E-12 4.249E-10 4.069E-9 9.348E-9 4 5
23 18671972 IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. Pubmed 3.461E-12 1.121E-9 1.074E-8 2.803E-8 4 6
24 15806162 Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Pubmed 3.461E-12 1.121E-9 1.074E-8 2.803E-8 4 6
25 24029232 Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Pubmed 3.461E-12 1.121E-9 1.074E-8 2.803E-8 4 6
26 10781615 The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB family. Pubmed 8.072E-12 2.514E-9 2.408E-8 6.537E-8 4 7
27 9685505 Casein kinase II interacts with the bZIP domains of several transcription factors. Pubmed 1.614E-11 4.506E-9 4.315E-8 1.307E-7 4 8
28 21937452 Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. Pubmed 1.614E-11 4.506E-9 4.315E-8 1.307E-7 4 8
29 14685163 Roles of CHOP/GADD153 in endoplasmic reticulum stress. Pubmed 1.614E-11 4.506E-9 4.315E-8 1.307E-7 4 8
30 26147683 The transcription factor XBP1 is selectively required for eosinophil differentiation. Pubmed 2.434E-11 6.571E-9 6.293E-8 1.971E-7 5 31
31 9405372 Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. Pubmed 2.903E-11 7.346E-9 7.035E-8 2.351E-7 4 9
32 24411941 Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers. Pubmed 2.903E-11 7.346E-9 7.035E-8 2.351E-7 4 9
33 24658403 HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors. Pubmed 7.595E-11 1.809E-8 1.732E-7 6.151E-7 4 11
34 8530045 Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Pubmed 7.595E-11 1.809E-8 1.732E-7 6.151E-7 4 11
35 9494081 Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha). Pubmed 1.644E-10 3.804E-8 3.643E-7 1.331E-6 4 13
36 15588942 Protein partners of C/EBPepsilon. Pubmed 2.300E-10 4.843E-8 4.638E-7 1.863E-6 4 14
37 24244375 HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways. Pubmed 2.300E-10 4.843E-8 4.638E-7 1.863E-6 4 14
38 9139739 ATF-2 and C/EBPalpha can form a heterodimeric DNA binding complex in vitro. Functional implications for transcriptional regulation. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
39 2196176 Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
40 18635891 Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
41 17042743 A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
42 26667036 C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
43 9428809 Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
44 20460359 CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
45 12215258 Transcriptional activation of C/EBPbeta gene by c-Jun and ATF2. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
46 16049073 Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
47 19384981 The immediate-early oncoproteins Fra-1, c-Fos, and c-Jun have distinguishable surface behavior and interactions with phospholipids. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
48 12036869 Induction of granulocytic differentiation by 2 pathways. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
49 1371993 Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
50 16632469 CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system. Pubmed 3.528E-10 4.843E-8 4.638E-7 2.857E-6 3 3
Show 45 more annotations

9: Interaction [Display Chart] 28 input genes in category / 1570 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CEBPG CEBPG interactions 2.352E-34 3.693E-31 2.931E-30 3.693E-31 14 27
2 int:ATF4 ATF4 interactions 4.268E-26 3.350E-23 2.659E-22 6.701E-23 14 85
3 int:JUN JUN interactions 7.014E-26 3.671E-23 2.913E-22 1.101E-22 18 296
4 int:ATF3 ATF3 interactions 2.738E-25 1.075E-22 8.529E-22 4.299E-22 13 66
5 int:DDIT3 DDIT3 interactions 3.498E-24 1.098E-21 8.717E-21 5.492E-21 13 79
6 int:BATF BATF interactions 5.514E-24 1.443E-21 1.145E-20 8.656E-21 10 21
7 int:FOSL1 FOSL1 interactions 9.442E-24 2.118E-21 1.681E-20 1.482E-20 11 36
8 int:CEBPE CEBPE interactions 4.527E-22 8.884E-20 7.050E-19 7.107E-19 11 49
9 int:FOS FOS interactions 1.938E-21 3.381E-19 2.683E-18 3.043E-18 14 176
10 int:CEBPA CEBPA interactions 2.801E-20 4.397E-18 3.489E-17 4.397E-17 14 212
11 int:BATF3 BATF3 interactions 3.797E-20 5.419E-18 4.301E-17 5.961E-17 10 44
12 int:ATF2 ATF2 interactions 7.428E-20 9.719E-18 7.713E-17 1.166E-16 14 227
13 int:JUNB JUNB interactions 9.256E-18 1.118E-15 8.871E-15 1.453E-14 10 73
14 int:CEBPB CEBPB interactions 1.832E-16 2.055E-14 1.631E-13 2.877E-13 10 97
15 int:CREB1 CREB1 interactions 1.047E-15 1.096E-13 8.700E-13 1.644E-12 11 173
16 int:DNMT3L DNMT3L interactions 6.277E-15 6.159E-13 4.888E-12 9.855E-12 9 86
17 int:CREBBP CREBBP interactions 8.515E-15 7.864E-13 6.241E-12 1.337E-11 13 398
18 int:SPI1 SPI1 interactions 2.741E-14 2.391E-12 1.897E-11 4.303E-11 8 59
19 int:JDP2 JDP2 interactions 7.162E-14 5.918E-12 4.696E-11 1.124E-10 7 35
20 int:SRA1 SRA1 interactions 3.403E-13 2.672E-11 2.120E-10 5.343E-10 7 43
21 int:MAFB MAFB interactions 8.743E-13 6.537E-11 5.188E-10 1.373E-9 6 23
22 int:NFATC1 NFATC1 interactions 1.130E-12 8.066E-11 6.402E-10 1.775E-9 9 151
23 int:JUND JUND interactions 2.752E-12 1.879E-10 1.491E-9 4.321E-9 7 57
24 int:MAF MAF interactions 4.088E-12 2.674E-10 2.122E-9 6.418E-9 6 29
25 int:ATF1 ATF1 interactions 5.169E-11 3.246E-9 2.576E-8 8.115E-8 6 43
26 int:BATF2 BATF2 interactions 5.733E-11 3.462E-9 2.748E-8 9.002E-8 5 18
27 int:MLLT6 MLLT6 interactions 1.337E-10 7.776E-9 6.171E-8 2.100E-7 6 50
28 int:CREB5 CREB5 interactions 2.164E-10 1.214E-8 9.631E-8 3.398E-7 6 54
29 int:GTF2F2 GTF2F2 interactions 2.427E-10 1.314E-8 1.043E-7 3.810E-7 6 55
30 int:NFYA NFYA interactions 7.517E-10 3.934E-8 3.122E-7 1.180E-6 6 66
31 int:BARX2 BARX2 interactions 1.044E-9 5.288E-8 4.197E-7 1.639E-6 4 10
32 int:UBE2I UBE2I interactions 1.528E-9 7.434E-8 5.900E-7 2.399E-6 10 476
33 int:ARHGAP22 ARHGAP22 interactions 1.563E-9 7.434E-8 5.900E-7 2.453E-6 5 33
34 int:CEBPD CEBPD interactions 1.830E-9 8.450E-8 6.706E-7 2.873E-6 5 34
35 int:EDF1 EDF1 interactions 2.133E-9 9.567E-8 7.592E-7 3.348E-6 5 35
36 int:YY1 YY1 interactions 2.300E-9 1.003E-7 7.961E-7 3.611E-6 7 146
37 int:XBP1 XBP1 interactions 2.474E-9 1.050E-7 8.331E-7 3.884E-6 5 36
38 int:SMAD3 SMAD3 interactions 4.541E-9 1.876E-7 1.489E-6 7.129E-6 9 383
39 int:ATF7 ATF7 interactions 4.891E-9 1.969E-7 1.563E-6 7.679E-6 5 41
40 int:RB1 RB1 interactions 5.772E-9 2.265E-7 1.798E-6 9.061E-6 8 267
41 int:ATF5 ATF5 interactions 6.751E-9 2.585E-7 2.052E-6 1.060E-5 4 15
42 int:SNAPC5 SNAPC5 interactions 1.174E-8 4.390E-7 3.484E-6 1.844E-5 4 17
43 int:NFIL3 NFIL3 interactions 1.508E-8 5.382E-7 4.272E-6 2.368E-5 4 18
44 int:DBP DBP interactions 1.508E-8 5.382E-7 4.272E-6 2.368E-5 4 18
45 int:GSK3B GSK3B interactions 3.227E-8 1.126E-6 8.936E-6 5.067E-5 8 333
46 int:FOSL2 FOSL2 interactions 3.492E-8 1.192E-6 9.459E-6 5.482E-5 5 60
47 int:STAT6 STAT6 interactions 9.469E-8 3.163E-6 2.510E-5 1.487E-4 5 73
48 int:NFE2L2 NFE2L2 interactions 1.014E-7 3.318E-6 2.633E-5 1.593E-4 5 74
49 int:NCOA6 NCOA6 interactions 2.041E-7 6.540E-6 5.190E-5 3.205E-4 5 85
50 int:SRF SRF interactions 2.430E-7 7.630E-6 6.055E-5 3.815E-4 5 88
Show 45 more annotations

10: Cytoband [Display Chart] 28 input genes in category / 27 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q13 12q13 1.511E-3 1.090E-2 4.242E-2 4.079E-2 2 71
2 8p11.2-p11.1 8p11.2-p11.1 1.615E-3 1.090E-2 4.242E-2 4.361E-2 1 2
3 2q23 2q23 1.615E-3 1.090E-2 4.242E-2 4.361E-2 1 2
4 20q11.2-q13.1 20q11.2-q13.1 1.615E-3 1.090E-2 4.242E-2 4.361E-2 1 2
5 14q24.3 14q24.3 2.682E-3 1.448E-2
5.637E-2
7.242E-2
 2 95
6 3q22.2 3q22.2 3.228E-3 1.452E-2
5.652E-2
8.714E-2
 1 4
7 3p24 3p24 6.445E-3 2.415E-2
9.398E-2
1.740E-1
 1 8
8 1p32-p31 1p32-p31 8.050E-3 2.415E-2
9.398E-2
2.173E-1
 1 10
9 20q13.1 20q13.1 8.050E-3 2.415E-2
9.398E-2
2.173E-1
 1 10
10 1q22-q23 1q22-q23 1.045E-2 2.669E-2
1.039E-1
2.822E-1
 1 13
11 2q32 2q32 1.125E-2 2.669E-2
1.039E-1
3.038E-1
 1 14
12 22q12 22q12 1.205E-2 2.669E-2
1.039E-1
3.254E-1
 1 15
13 2p22.2 2p22.2 1.285E-2 2.669E-2
1.039E-1
3.469E-1
 1 16
14 10p11.21 10p11.21 1.524E-2 2.939E-2
1.144E-1
4.115E-1
 1 19
15 2q34 2q34 2.317E-2 3.910E-2
1.522E-1
6.257E-1
 1 29
16 1q32.3 1q32.3 2.317E-2 3.910E-2
1.522E-1
6.257E-1
 1 29
17 1p34 1p34 2.554E-2 4.056E-2
1.579E-1
6.896E-1
 1 32
18 22q12.1 22q12.1 2.712E-2 4.067E-2
1.583E-1
7.321E-1
 1 34
Show 13 more annotations

11: Transcription Factor Binding Site [Display Chart] 24 input genes in category / 323 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$MEF2 03 V$MEF2 03 1.009E-4 2.606E-2
1.657E-1
 3.261E-2 5 198
2 V$TAXCREB 01 V$TAXCREB 01 1.614E-4 2.606E-2
1.657E-1
5.213E-2
 4 115

12: Gene Family [Display Chart] 26 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 506 Basic leucine zipper proteins genenames.org 4.163E-59 3.746E-58 1.060E-57 3.746E-58 23 49
2 1165 CCAAT/enhancer binding proteins genenames.org 4.574E-18 2.058E-17 5.823E-17 4.116E-17 6 6
3 1257 Basic leucine zipper proteins|Jun transcription factor family genenames.org 5.886E-6 1.766E-5 4.995E-5 5.297E-5 2 3
4 1256 Basic leucine zipper proteins|Fos transcription factor family genenames.org 1.176E-5 2.646E-5 7.486E-5 1.059E-4 2 4
5 1058 ATAC complex genenames.org 1.843E-2 3.089E-2
8.740E-2
1.658E-1
 1 13
6 486 Basic helix-loop-helix proteins|Lysine acetyltransferases genenames.org 2.403E-2 3.089E-2
8.740E-2
2.163E-1
 1 17
7 1059 SAGA complex genenames.org 2.403E-2 3.089E-2
8.740E-2
2.163E-1
 1 17
8 1134 GCN5 related N-acetyltransferases genenames.org 3.376E-2 3.798E-2
1.074E-1
3.038E-1
 1 24
Show 3 more annotations

13: Coexpression [Display Chart] 28 input genes in category / 3582 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18689800-TableS6 Human EmbryonicStemCell Thomas08 113genes GeneSigDB 6.232E-13 2.232E-9 1.956E-8 2.232E-9 8 111
2 M11516 Selected genes changed in K562 (immortalized erythroleukemia) cells induced by hemin [PubChem=26945] treatment to express erythroid properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.852E-10 3.432E-7 3.007E-6 1.021E-6 6 73
3 M7300 Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.650E-10 3.432E-7 3.007E-6 1.308E-6 8 245
4 M16336 Up-regulated genes in MM1.S cells (multiple myeloma) treated with adaphostin [PubChem=387042], a tyrosine kinase inhibitor with anticancer properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.832E-10 3.432E-7 3.007E-6 1.373E-6 7 147
5 M6267 An assortment of osteoblast transcriptional regulators. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.703E-9 1.220E-6 1.069E-5 6.099E-6 4 14
6 17952126-Table1 Human Bladder Buytaert08 47genes GeneSigDB 2.358E-9 1.322E-6 1.159E-5 8.445E-6 5 46
7 M14151 Genes up-regulated in HEK293 cells (embryonic kidney) at 6 h, 12 h or 24 h after infection with reovirus strain T3A (known as a strong inducer of apoptosis). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.584E-9 1.322E-6 1.159E-5 9.256E-6 8 314
8 M7132 Genes up-regulated in peripheral blood monocytes (PMBC): Gram positive sepsis versus mixed infection sepsis. MSigDB C7: Immunologic Signatures (v6.0) 3.296E-9 1.334E-6 1.169E-5 1.180E-5 7 200
9 15479729-Table2 Human Lymphoma Guedez05 17genes GeneSigDB 4.038E-9 1.334E-6 1.169E-5 1.447E-5 4 17
10 M4035 Genes from the red module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.038E-9 1.334E-6 1.169E-5 1.447E-5 4 17
11 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v6.0) 4.096E-9 1.334E-6 1.169E-5 1.467E-5 6 113
12 17699800-Table1 Human Lung Joo07 54genes GeneSigDB 5.404E-9 1.613E-6 1.413E-5 1.936E-5 5 54
13 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.843E-8 7.833E-6 6.863E-5 1.018E-4 6 156
14 19286929-SuppTable2i Mouse Lung Rangasamy09 248genes GeneSigDB 4.422E-8 1.131E-5 9.913E-5 1.584E-4 6 168
15 15892885-tableS1b Human Prostate Chandran05 101genes Donor v AdjNormal GeneSigDB 4.843E-8 1.157E-5 1.013E-4 1.735E-4 5 83
16 M8792 Genes up-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v6.0) 7.117E-8 1.593E-5 1.396E-4 2.549E-4 6 182
17 M11218 Examples of transcription factors whose activities are regulated by MAPK7 [GeneID=5598] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.852E-8 1.762E-5 1.543E-4 3.171E-4 3 8
18 M9841 Examples of transcription factors whose activities are regulated by MAPK8 and MAPK9 [GeneID=5599;5601]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.852E-8 1.762E-5 1.543E-4 3.171E-4 3 8
19 M2191 Genes responding to progestin R5020 [PubChem=36709] treatment of T47D-MTVL cells (breast cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.839E-8 1.855E-5 1.625E-4 3.524E-4 4 36
20 M7252 Genes up-regulated in thymocytes: cortical versus medullary sources. MSigDB C7: Immunologic Signatures (v6.0) 1.208E-7 2.122E-5 1.860E-4 4.327E-4 6 199
21 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v6.0) 1.244E-7 2.122E-5 1.860E-4 4.457E-4 6 200
22 M8991 Selected genes up-regulated in DU145 and PC-3 cells (prostate cancer) after treatment with the NSAID (non-steroid anti-inflammatory drug) sulindac [PubChem=5352]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.327E-7 2.160E-5 1.893E-4 4.753E-4 3 9
23 15885264-Table1 Mouse Lung not cancer Lee05 127genes GeneSigDB 1.738E-7 2.707E-5 2.372E-4 6.227E-4 5 107
24 M17621 Genes up-regulated 9 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.365E-7 3.530E-5 3.092E-4 8.471E-4 6 223
25 18769717-TableS2 Mouse Lung Taylor08 46genes GeneSigDB 2.703E-7 3.873E-5 3.393E-4 9.682E-4 4 46
26 15548366-Table2 Mouse Bladder Yao04 53genes GeneSigDB 3.218E-7 4.433E-5 3.884E-4 1.153E-3 4 48
27 M12391 Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [GeneID=6774] off an adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.501E-7 4.540E-5 3.977E-4 1.254E-3 4 49
28 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.554E-7 4.540E-5 3.977E-4 1.273E-3 6 239
29 17571080-SuppTable2b Human Leukemia Sun07 283genes GeneSigDB 3.732E-7 4.540E-5 3.977E-4 1.337E-3 6 241
30 15735721-Table1 Human Lung Dauer05 50genes OverExpressed GeneSigDB 3.802E-7 4.540E-5 3.977E-4 1.362E-3 4 50
31 M19693 Genes up-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.012E-7 4.636E-5 4.062E-4 1.437E-3 6 244
32 M16311 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.958E-7 7.725E-5 6.768E-4 2.492E-3 4 58
33 M8796 Genes up-regulated in splenocytes from Foxp3-Fusion-GFP NOD mice: T reg (FOXP3+ [GeneID=50943]) versus T conv (FOXP3- [GeneID=50943]) cells. MSigDB C7: Immunologic Signatures (v6.0) 7.117E-7 7.725E-5 6.768E-4 2.549E-3 5 142
34 M8789 Genes up-regulated in peritoneal macrophages: poly(IC) versus Pam3Cys-Ser-(Lys)4 [PubChem=130704]. MSigDB C7: Immunologic Signatures (v6.0) 8.166E-7 8.603E-5 7.537E-4 2.925E-3 5 146
35 M7623 Genes down-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.156E-7 9.371E-5 8.210E-4 3.280E-3 6 281
36 M2496 Genes up-regulated in Calu-6 cells (lung cancer) at 1 h time point after TNF [GeneID=7124] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.728E-7 9.680E-5 8.481E-4 3.485E-3 4 63
37 17545589-Table2 Human Prostate Tamura07 70genes GeneSigDB 1.104E-6 1.069E-4 9.363E-4 3.954E-3 4 65
38 M10550 Delayed early genes (DEG) which are coordinately down-regulated in multiple epithelial tumor types. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.279E-6 1.206E-4 1.057E-3 4.583E-3 3 18
39 11906190-Table1a-1 Human Colon Iizaka02 81genes GeneSigDB 1.489E-6 1.367E-4 1.198E-3 5.333E-3 4 70
40 16269079-TableS1 Human StemCell Cui05 71genes GeneSigDB 1.576E-6 1.412E-4 1.237E-3 5.647E-3 4 71
41 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.995E-6 1.743E-4 1.527E-3 7.147E-3 5 175
42 15246160-table4 Human StemCell Shim04 23genes GeneSigDB 2.407E-6 2.005E-4 1.757E-3 8.622E-3 3 22
43 19555670-Table3a Human Lymphoma Cassinelli09 33genes GeneSigDB 2.407E-6 2.005E-4 1.757E-3 8.622E-3 3 22
44 M2504 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.625E-6 2.095E-4 1.836E-3 9.404E-3 6 337
45 M4517 Genes up-regulated in multiple myeloma (MM) compared to normal plasma cells from the patient's identical twin. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.677E-6 2.095E-4 1.836E-3 9.589E-3 4 81
46 M8802 Genes down-regulated in Foxp3-Fusion-GFP T reg (FOXP3+ [GeneID=50943]): B6 versus NOD background. MSigDB C7: Immunologic Signatures (v6.0) 2.691E-6 2.095E-4 1.836E-3 9.639E-3 5 186
47 M1981 Genes up-regulated in CD4+ [GeneID=920] T lymphocytes transduced with FOXP3 [GeneID=50943]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.766E-6 2.108E-4 1.847E-3 9.907E-3 3 23
48 18701491-Table2 Human Leukemia Krige08 29genes GeneSigDB 3.586E-6 2.452E-4 2.149E-3 1.285E-2 3 25
49 M9568 Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 3.745E-6 2.452E-4 2.149E-3 1.342E-2 5 199
50 M3082 Genes down-regulated in comparison of healthy B cells versus healthy myeloid cells. MSigDB C7: Immunologic Signatures (v6.0) 3.838E-6 2.452E-4 2.149E-3 1.375E-2 5 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 28 input genes in category / 2390 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Loop of Henle (LH) Loop of Henle (LH) 2.061E-12 4.925E-9 4.116E-8 4.925E-9 9 198
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK8 Adult, Development, and Cancer types 1.268E-11 1.515E-8 1.266E-7 3.030E-8 8 152
3 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Plasma Cell Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Plasma Cell Top 200 Genes 2.453E-10 1.954E-7 1.633E-6 5.862E-7 9 338
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Adult, Development, and Cancer types 3.832E-9 2.290E-6 1.913E-5 9.159E-6 7 193
5 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-S100A9, LYZ, S100A8 Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-S100A9, LYZ, S100A8 Top 200 Genes 1.523E-8 7.279E-6 6.083E-5 3.640E-5 8 372
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour VHL RCC U U/Kidney Tumour VHL RCC U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour VHL RCC U U/Kidney Tumour VHL RCC U21 Adult, Development, and Cancer types 3.723E-8 1.483E-5 1.239E-4 8.898E-5 4 27
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney N11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney N11 Adult, Development, and Cancer types 1.102E-7 3.028E-5 2.530E-4 2.634E-4 6 185
8 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Bladder Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Bladder Tabula Muris Consortium 1.212E-7 3.028E-5 2.530E-4 2.898E-4 6 188
9 10X Human 8K PBMC CD14+ Monocytes Top 200 10X Human 8K PBMC CD14+ Monocytes Top 200 1.357E-7 3.028E-5 2.530E-4 3.243E-4 8 494
10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IN-U/Ureter Normal RCC IN-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IN-U/Ureter Normal RCC IN-U Adult, Development, and Cancer types 1.460E-7 3.028E-5 2.530E-4 3.489E-4 6 194
11 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Eo/B/Mast Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Eo/B/Mast Top 200 Genes 1.526E-7 3.028E-5 2.530E-4 3.648E-4 7 330
12 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 1.647E-7 3.028E-5 2.530E-4 3.936E-4 6 198
13 Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes 1.647E-7 3.028E-5 2.530E-4 3.936E-4 6 198
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Tumour RCC MNP RCC2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Tumour RCC MNP RCC2 Adult, Development, and Cancer types 2.314E-7 3.950E-5 3.301E-4 5.530E-4 5 107
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Tumour RCC MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Tumour RCC MNP2 Adult, Development, and Cancer types 4.452E-7 7.094E-5 5.928E-4 1.064E-3 5 122
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal VHL RCC NK cell/Kidney Normal VHL RCC NK18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal VHL RCC NK cell/Kidney Normal VHL RCC NK18 Adult, Development, and Cancer types 5.227E-7 7.808E-5 6.525E-4 1.249E-3 5 126
17 GSM854320 500 Myeloid Cells, MF.Lv, CD45+ F4/80+ CD11b+, Liver, avg-2 Immgen.org, GSE15907 5.781E-7 8.062E-5 6.737E-4 1.382E-3 7 402
18 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.072E-7 8.062E-5 6.737E-4 1.451E-3 4 53
19 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Fos BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Fos BrainMap 1.867E-6 2.349E-4 1.963E-3 4.463E-3 5 163
20 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.863E-6 2.620E-4 2.190E-3 6.844E-3 3 22
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla Wilms NK cell/Kidney Normal-Medulla Wilms NK14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla Wilms NK cell/Kidney Normal-Medulla Wilms NK14 Adult, Development, and Cancer types 3.295E-6 2.620E-4 2.190E-3 7.874E-3 5 183
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F11 Adult, Development, and Cancer types 3.295E-6 2.620E-4 2.190E-3 7.874E-3 5 183
23 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 3.384E-6 2.620E-4 2.190E-3 8.087E-3 5 184
24 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hMgl Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.384E-6 2.620E-4 2.190E-3 8.087E-3 5 184
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour RCC PT-U/Kidney Tumour RCC PT7 Adult, Development, and Cancer types 3.475E-6 2.620E-4 2.190E-3 8.305E-3 5 185
26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F7 Adult, Development, and Cancer types 3.475E-6 2.620E-4 2.190E-3 8.305E-3 5 185
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R7 Adult, Development, and Cancer types 3.475E-6 2.620E-4 2.190E-3 8.305E-3 5 185
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour RCC NK cell/Kidney Tumour RCC NK7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour RCC NK cell/Kidney Tumour RCC NK7 Adult, Development, and Cancer types 3.568E-6 2.620E-4 2.190E-3 8.526E-3 5 186
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour RCC IF-U/Kidney Tumour RCC IF7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour RCC IF-U/Kidney Tumour RCC IF7 Adult, Development, and Cancer types 3.568E-6 2.620E-4 2.190E-3 8.526E-3 5 186
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Tumour RCC EN-A/Kidney Tumour RCC EN7 Adult, Development, and Cancer types 3.662E-6 2.620E-4 2.190E-3 8.753E-3 5 187
31 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R18 Adult, Development, and Cancer types 3.662E-6 2.620E-4 2.190E-3 8.753E-3 5 187
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour RCC Endothelium/Kidney Tumour RCC N7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour RCC Endothelium/Kidney Tumour RCC N7 Adult, Development, and Cancer types 3.759E-6 2.620E-4 2.190E-3 8.984E-3 5 188
33 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag Tabula Muris Consortium 3.858E-6 2.620E-4 2.190E-3 9.220E-3 5 189
34 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Gran Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype CD34+ Gran Top 200 Genes 3.986E-6 2.620E-4 2.190E-3 9.527E-3 6 342
35 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Overall Top 200 Genes 4.061E-6 2.620E-4 2.190E-3 9.707E-3 5 191
36 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Top 200 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Top 200 4.166E-6 2.620E-4 2.190E-3 9.958E-3 5 192
37 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Overall Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes (S100A9, S100A8, LYZ) Overall Top 200 Genes 4.166E-6 2.620E-4 2.190E-3 9.958E-3 5 192
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U21 Adult, Development, and Cancer types 4.166E-6 2.620E-4 2.190E-3 9.958E-3 5 192
39 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea Tabula Muris Consortium 4.383E-6 2.686E-4 2.244E-3 1.047E-2 5 194
40 Mesangium (MG)/Mesangium (MG) a Mesangium (MG)/Mesangium (MG) a 4.608E-6 2.753E-4 2.301E-3 1.101E-2 5 196
41 10X Human 8K PBMC Myeloid Subtype Myeloid-S100A9 CST3 S100A8 A Top 200 Genes 10X Human 8K PBMC Myeloid Subtype Myeloid-S100A9 CST3 S100A8 A Top 200 Genes 5.018E-6 2.925E-4 2.444E-3 1.199E-2 6 356
42 GSM854326 100 Myeloid Cells, MF.Microglia.CNS, CD45low CD11b+ F4/80+, Brain, avg-3 Immgen.org, GSE15907 5.359E-6 3.000E-4 2.507E-3 1.281E-2 4 91
43 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Rgs5/Acta2,Rgs5//Fos BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Rgs5/Acta2,Rgs5//Fos BrainMap 5.415E-6 3.000E-4 2.507E-3 1.294E-2 3 27
44 10X Human 8K PBMC Myeloid Subtype Myeloid-MNDA, CSTA, RP11-1143G9.4 Top 200 Genes 10X Human 8K PBMC Myeloid Subtype Myeloid-MNDA, CSTA, RP11-1143G9.4 Top 200 Genes 5.522E-6 3.000E-4 2.507E-3 1.320E-2 6 362
45 GSM854258 500 Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4 Immgen.org, GSE15907 6.067E-6 3.222E-4 2.693E-3 1.450E-2 6 368
46 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-FCN1, LYZ, CTSS Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes-FCN1, LYZ, CTSS Top 200 Genes 6.356E-6 3.302E-4 2.759E-3 1.519E-2 6 371
47 gudmap dev gonad e11.5 F ReproVasc Flk k1 500 dev gonad e11.5 F ReproVasc Flk k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.753E-6 3.434E-4 2.870E-3 1.614E-2 3 29
48 10X Human 68K PBMC CD14+ Monocyte Subtype CD14+ Monocyte-CD14+ Monocyte c4 Top 200 Genes 10X Human 68K PBMC CD14+ Monocyte Subtype CD14+ Monocyte-CD14+ Monocyte c4 Top 200 Genes 7.970E-6 3.866E-4 3.231E-3 1.905E-2 6 386
49 10X Human 8K PBMC Myeloid Subtype Myeloid-LST1 CST3 AIF1 Top 200 Genes 10X Human 8K PBMC Myeloid Subtype Myeloid-LST1 CST3 AIF1 Top 200 Genes 7.970E-6 3.866E-4 3.231E-3 1.905E-2 6 386
50 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes- HLA-DRA, HLA-DPB1, HLA-DPA1 Top 200 Genes 10X Human 8K PBMC CD14+ Monocytes Subtype CD14+ Monocytes- HLA-DRA, HLA-DPB1, HLA-DPA1 Top 200 Genes 8.088E-6 3.866E-4 3.231E-3 1.933E-2 6 387
Show 45 more annotations

15: Computational [Display Chart] 26 input genes in category / 170 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4092 MODULE 197 Genes in the cancer module 197. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.315E-9 1.414E-6 8.080E-6 1.414E-6 8 174
2 M13751 MODULE 123 Genes in the cancer module 123. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.214E-6 1.882E-4 1.076E-3 3.764E-4 7 247
3 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.611E-5 2.613E-3 1.494E-2 7.839E-3 7 393
4 M413 MODULE 273 Phosphate metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.135E-4 1.328E-2
7.590E-2
5.330E-2
 3 52
5 M17265 GNF2 PECAM1 Neighborhood of PECAM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.905E-4 1.328E-2
7.590E-2
6.639E-2
 3 56
6 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.468E-4 2.683E-2
1.533E-1
1.610E-1
 5 303
7 M17322 MODULE 76 Inflammatory response. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.152E-3 2.797E-2
1.599E-1
1.958E-1
 3 81
Show 2 more annotations

16: MicroRNA [Display Chart] 28 input genes in category / 917 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 3.818E-7 2.298E-4 1.700E-3 3.501E-4 5 387
2 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 5.011E-7 2.298E-4 1.700E-3 4.596E-4 5 409
3 hsa-miR-140-5p:TargetScan hsa-miR-140-5p TargetScan 5.445E-6 1.664E-3 1.231E-2 4.993E-3 4 299
4 hsa-miR-1537:mirSVR highEffct hsa-miR-1537:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.669E-6 2.217E-3 1.640E-2 8.867E-3 4 346
5 GAGCTGG,MIR-337:MSigDB GAGCTGG,MIR-337:MSigDB MSigDB 2.767E-5 3.881E-3 2.872E-2 2.537E-2 3 150
6 ACCATTT,MIR-522:MSigDB ACCATTT,MIR-522:MSigDB MSigDB 2.878E-5 3.881E-3 2.872E-2 2.639E-2 3 152
7 hsa-miR-369-3p:TargetScan hsa-miR-369-3p TargetScan 2.968E-5 3.881E-3 2.872E-2 2.722E-2 4 461
8 hsa-miR-190b:TargetScan hsa-miR-190b TargetScan 3.809E-5 3.881E-3 2.872E-2 3.493E-2 3 167
9 hsa-miR-190a-5p:TargetScan hsa-miR-190a-5p TargetScan 3.809E-5 3.881E-3 2.872E-2 3.493E-2 3 167
10 hsa-miR-375:PITA hsa-miR-375:PITA TOP PITA 4.681E-5 4.293E-3 3.176E-2 4.293E-2 2 26
11 hsa-miR-490-5p:Functional MTI Functional MTI miRTarbase 1.177E-4 9.041E-3
6.690E-2
1.079E-1
 2 41
12 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 1.812E-4 9.041E-3
6.690E-2
1.662E-1
 3 283
13 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 1.812E-4 9.041E-3
6.690E-2
1.662E-1
 3 283
14 hsa-miR-802:TargetScan hsa-miR-802 TargetScan 1.869E-4 9.041E-3
6.690E-2
1.714E-1
 3 286
15 GTGCAAT,MIR-367:MSigDB GTGCAAT,MIR-367:MSigDB MSigDB 1.927E-4 9.041E-3
6.690E-2
1.767E-1
 3 289
16 GTGCAAT,MIR-92:MSigDB GTGCAAT,MIR-92:MSigDB MSigDB 1.927E-4 9.041E-3
6.690E-2
1.767E-1
 3 289
17 GTGCAAT,MIR-25:MSigDB GTGCAAT,MIR-25:MSigDB MSigDB 1.927E-4 9.041E-3
6.690E-2
1.767E-1
 3 289
18 GTGCAAT,MIR-363:MSigDB GTGCAAT,MIR-363:MSigDB MSigDB 1.927E-4 9.041E-3
6.690E-2
1.767E-1
 3 289
19 GTGCAAT,MIR-32:MSigDB GTGCAAT,MIR-32:MSigDB MSigDB 1.927E-4 9.041E-3
6.690E-2
1.767E-1
 3 289
20 hsa-miR-8083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.972E-4 9.041E-3
6.690E-2
1.808E-1
 2 53
21 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 2.279E-4 9.511E-3
7.037E-2
2.090E-1
 3 306
22 hsa-miR-193a-5p:Functional MTI Functional MTI miRTarbase 2.282E-4 9.511E-3
7.037E-2
2.092E-1
 2 57
23 TATCTGG,MIR-488:MSigDB TATCTGG,MIR-488:MSigDB MSigDB 2.529E-4 9.973E-3
7.379E-2
2.319E-1
 2 60
24 hsa-miR-580:PITA hsa-miR-580:PITA TOP PITA 2.694E-4 9.973E-3
7.379E-2
2.471E-1
 3 324
25 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 2.719E-4 9.973E-3
7.379E-2
2.493E-1
 3 325
26 hsa-miR-501-5p:PITA hsa-miR-501-5p:PITA TOP PITA 3.102E-4 1.094E-2
8.095E-2
2.845E-1
 3 340
27 hsa-miR-627-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.344E-4 1.106E-2
8.181E-2
3.067E-1
 2 69
28 hsa-miR-563:mirSVR highEffct hsa-miR-563:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.376E-4 1.106E-2
8.181E-2
3.096E-1
 3 350
29 hsa-miR-875-5p:TargetScan hsa-miR-875-5p TargetScan 3.743E-4 1.183E-2
8.756E-2
3.432E-1
 2 73
30 hsa-miR-181b-5p:Functional MTI Functional MTI miRTarbase 4.128E-4 1.262E-2
9.336E-2
3.785E-1
 3 375
31 hsa-miR-191-5p:Functional MTI Functional MTI miRTarbase 4.272E-4 1.264E-2
9.349E-2
3.917E-1
 2 78
32 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 4.423E-4 1.267E-2
9.378E-2
4.056E-1
 3 384
33 hsa-miR-937-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-4 1.344E-2
9.940E-2
4.434E-1
 2 83
34 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 5.388E-4 1.453E-2
1.075E-1
4.941E-1
 3 411
35 hsa-miR-1234:mirSVR lowEffct hsa-miR-1234:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.857E-4 1.534E-2
1.135E-1
5.371E-1
 3 423
36 hsa-miR-8081:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.194E-4 1.569E-2
1.161E-1
5.680E-1
 2 94
37 GTGTTGA,MIR-505:MSigDB GTGTTGA,MIR-505:MSigDB MSigDB 7.144E-4 1.569E-2
1.161E-1
6.551E-1
 2 101
38 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 7.325E-4 1.569E-2
1.161E-1
6.717E-1
 3 457
39 TGAATGT,MIR-181A:MSigDB TGAATGT,MIR-181A:MSigDB MSigDB 7.701E-4 1.569E-2
1.161E-1
7.062E-1
 3 465
40 TGAATGT,MIR-181C:MSigDB TGAATGT,MIR-181C:MSigDB MSigDB 7.701E-4 1.569E-2
1.161E-1
7.062E-1
 3 465
41 TGAATGT,MIR-181B:MSigDB TGAATGT,MIR-181B:MSigDB MSigDB 7.701E-4 1.569E-2
1.161E-1
7.062E-1
 3 465
42 TGAATGT,MIR-181D:MSigDB TGAATGT,MIR-181D:MSigDB MSigDB 7.701E-4 1.569E-2
1.161E-1
7.062E-1
 3 465
43 hsa-miR-139-5p:Functional MTI Functional MTI miRTarbase 7.717E-4 1.569E-2
1.161E-1
7.076E-1
 2 105
44 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 8.440E-4 1.569E-2
1.161E-1
7.739E-1
 3 480
45 hsa-miR-1825:mirSVR highEffct hsa-miR-1825:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.490E-4 1.569E-2
1.161E-1
7.786E-1
 3 481
46 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.592E-4 1.569E-2
1.161E-1
7.879E-1
 3 483
47 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 8.747E-4 1.569E-2
1.161E-1
8.021E-1
 3 486
48 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 8.799E-4 1.569E-2
1.161E-1
8.069E-1
 3 487
49 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 8.799E-4 1.569E-2
1.161E-1
8.069E-1
 3 487
50 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 8.799E-4 1.569E-2
1.161E-1
8.069E-1
 3 487
Show 45 more annotations

17: Drug [Display Chart] 28 input genes in category / 8601 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000448381 2hqu Stitch 6.528E-19 5.615E-15 5.411E-14 5.615E-15 13 247
2 ctd:D003913 Dextroamphetamine CTD 1.475E-16 6.343E-13 6.113E-12 1.269E-12 11 186
3 CID000065351 APDC Stitch 1.075E-15 3.081E-12 2.969E-11 9.243E-12 12 318
4 CID000003154 Cosopt Stitch 2.482E-15 5.338E-12 5.144E-11 2.135E-11 12 341
5 ctd:C432165 pyrazolanthrone CTD 6.394E-14 1.039E-10 1.001E-9 5.499E-10 11 322
6 ctd:D017382 Reactive Oxygen Species CTD 7.320E-14 1.039E-10 1.001E-9 6.296E-10 11 326
7 ctd:D000841 Anisomycin CTD 8.456E-14 1.039E-10 1.001E-9 7.273E-10 8 86
8 CID000069608 iododimethylarsine Stitch 2.383E-13 2.562E-10 2.469E-9 2.050E-9 5 9
9 ctd:C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide CTD 4.060E-13 3.723E-10 3.588E-9 3.492E-9 9 173
10 ctd:C063998 nodularin CTD 4.329E-13 3.723E-10 3.588E-9 3.723E-9 6 26
11 CID000002162 amlodipine Stitch 1.940E-12 1.517E-9 1.462E-8 1.669E-8 8 126
12 CID000092815 methyloxoarsine Stitch 3.771E-12 2.703E-9 2.605E-8 3.243E-8 5 14
13 CID000016043 TBHQ Stitch 4.832E-12 3.197E-9 3.081E-8 4.156E-8 8 141
14 ctd:C093642 SB 203580 CTD 1.782E-11 1.095E-8 1.055E-7 1.532E-7 10 388
15 ctd:D020280 Sertraline CTD 7.396E-11 4.241E-8 4.087E-7 6.361E-7 7 115
16 ctd:C534735 tetraarsenic tetrasulfide CTD 9.152E-11 4.920E-8 4.741E-7 7.871E-7 6 60
17 ctd:C479072 delta-tocopherol CTD 1.227E-10 6.206E-8 5.980E-7 1.055E-6 5 26
18 ctd:C020972 pyrrolidine dithiocarbamic acid CTD 1.327E-10 6.343E-8 6.113E-7 1.142E-6 8 213
19 CID000114753 DIEP Stitch 1.504E-10 6.539E-8 6.302E-7 1.294E-6 5 27
20 ctd:C007262 deoxynivalenol CTD 1.521E-10 6.539E-8 6.302E-7 1.308E-6 10 483
21 ctd:C018584 linalool CTD 2.828E-10 1.158E-7 1.116E-6 2.432E-6 6 72
22 ctd:C008911 pimaric acid CTD 3.773E-10 1.475E-7 1.422E-6 3.245E-6 4 10
23 CID000007965 cyclohexylammonium Stitch 4.188E-10 1.566E-7 1.509E-6 3.602E-6 7 147
24 1068 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.075E-10 2.177E-7 2.098E-6 5.225E-6 7 155
25 ctd:D024504 gamma-Tocopherol CTD 6.971E-10 2.398E-7 2.311E-6 5.996E-6 5 36
26 ctd:C031655 tauroursodeoxycholic acid CTD 7.589E-10 2.511E-7 2.419E-6 6.528E-6 7 160
27 1069 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 8.279E-10 2.637E-7 2.542E-6 7.121E-6 7 162
28 486 UP calmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A Broad Institute CMAP Up 9.414E-10 2.892E-7 2.787E-6 8.097E-6 7 165
29 4454 UP thioridazine hydrochloride; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.068E-9 3.167E-7 3.052E-6 9.185E-6 7 168
30 4471 UP Astemizole [68844-77-9]; Up 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.113E-9 3.191E-7 3.075E-6 9.574E-6 7 169
31 ctd:D008752 Methylene Chloride CTD 1.160E-9 3.218E-7 3.102E-6 9.977E-6 7 170
32 ctd:C570000 niuhuang CTD 1.281E-9 3.444E-7 3.319E-6 1.102E-5 4 13
33 5070 UP Prenylamine lactate [69-43-2]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.729E-9 4.506E-7 4.342E-6 1.487E-5 7 180
34 ctd:C113580 U 0126 CTD 1.820E-9 4.603E-7 4.436E-6 1.565E-5 9 444
35 7045 UP lomustine; Up 200; 100uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.093E-9 5.143E-7 4.956E-6 1.800E-5 7 185
36 ctd:D003633 Dichlorodiphenyl Dichloroethylene CTD 2.159E-9 5.157E-7 4.970E-6 1.857E-5 8 303
37 ctd:C025340 manganese chloride CTD 2.387E-9 5.548E-7 5.347E-6 2.053E-5 9 458
38 ctd:D003994 Bucladesine CTD 2.518E-9 5.699E-7 5.492E-6 2.166E-5 8 309
39 ctd:C018637 phorone CTD 3.968E-9 8.751E-7 8.433E-6 3.413E-5 6 111
40 ctd:D002211 Capsaicin CTD 4.455E-9 9.580E-7 9.232E-6 3.832E-5 9 492
41 CID000000544 arsenite Stitch 6.243E-9 1.298E-6 1.251E-5 5.370E-5 8 347
42 ctd:D016718 Arachidonic Acid CTD 6.337E-9 1.298E-6 1.251E-5 5.451E-5 7 217
43 ctd:C028559 bathocuproine sulfonate CTD 6.680E-9 1.336E-6 1.288E-5 5.745E-5 6 121
44 CID000135808 n-sulfo-2-aminotricarballylate Stitch 8.633E-9 1.687E-6 1.626E-5 7.425E-5 4 20
45 CID004369394 AR E Stitch 9.476E-9 1.811E-6 1.745E-5 8.150E-5 7 230
46 CID000077341 4-nitroquinoline Stitch 1.065E-8 1.971E-6 1.900E-5 9.164E-5 4 21
47 ctd:C032688 boric acid CTD 1.077E-8 1.971E-6 1.900E-5 9.265E-5 5 61
48 ctd:D007811 Lanthanum CTD 1.301E-8 2.332E-6 2.247E-5 1.119E-4 4 22
49 ctd:C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole CTD 1.410E-8 2.474E-6 2.384E-5 1.212E-4 6 137
50 ctd:D008550 Melatonin CTD 1.507E-8 2.592E-6 2.498E-5 1.296E-4 7 246
Show 45 more annotations

18: Disease [Display Chart] 28 input genes in category / 642 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1333064 Classical Hodgkin's Lymphoma DisGeNET BeFree 2.962E-7 1.479E-4 1.041E-3 1.902E-4 6 163
2 C4045991 Perihilar Cholangiocarcinoma DisGeNET BeFree 5.499E-7 1.479E-4 1.041E-3 3.530E-4 3 10
3 C0014335 Enteritis DisGeNET Curated 6.909E-7 1.479E-4 1.041E-3 4.436E-4 4 41
4 C0272138 Erythroblastosis DisGeNET BeFree 1.555E-6 2.495E-4 1.757E-3 9.980E-4 4 50
5 C0085413 Polycystic Kidney, Autosomal Dominant DisGeNET Curated 4.456E-6 5.525E-4 3.891E-3 2.861E-3 5 145
6 C4020848 Aneurysmal disease DisGeNET Curated 5.164E-6 5.525E-4 3.891E-3 3.315E-3 3 20
7 C0036472 Scrub Typhus DisGeNET BeFree 1.036E-5 9.500E-4 6.691E-3 6.650E-3 3 25
8 C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 1.321E-5 9.988E-4 7.034E-3 8.479E-3 7 480
9 C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 1.400E-5 9.988E-4 7.034E-3 8.990E-3 6 317
10 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 1.655E-5 1.062E-3 7.482E-3 1.062E-2 7 497
11 C0271183 Severe myopia DisGeNET Curated 1.954E-5 1.132E-3 7.975E-3 1.254E-2 4 94
12 C0011119 Decompression Sickness DisGeNET BeFree 2.216E-5 1.132E-3 7.975E-3 1.423E-2 3 32
13 C0022680 Polycystic Kidney Diseases DisGeNET Curated 2.398E-5 1.132E-3 7.975E-3 1.539E-2 4 99
14 C0085281 Addictive Behavior DisGeNET BeFree 2.507E-5 1.132E-3 7.975E-3 1.610E-2 5 207
15 C0023492 Leukemia, T-Cell DisGeNET Curated 2.655E-5 1.132E-3 7.975E-3 1.704E-2 6 355
16 C1519689 Tumor Promotion DisGeNET BeFree 3.138E-5 1.132E-3 7.975E-3 2.014E-2 4 106
17 C0278883 Metastatic melanoma DisGeNET BeFree 3.151E-5 1.132E-3 7.975E-3 2.023E-2 6 366
18 C1368019 Paget Disease DisGeNET BeFree 3.175E-5 1.132E-3 7.975E-3 2.038E-2 3 36
19 C0206651 Sarcoma, Clear Cell DisGeNET Curated 3.743E-5 1.265E-3 8.906E-3 2.403E-2 3 38
20 C0040128 Thyroid Diseases DisGeNET Curated 4.779E-5 1.534E-3 1.080E-2 3.068E-2 4 118
21 C0403416 Idiopathic crescentic glomerulonephritis DisGeNET BeFree 7.119E-5 2.176E-3 1.533E-2 4.571E-2 3 47
22 C0010823 Cytomegalovirus Infections DisGeNET Curated 8.279E-5 2.394E-3 1.686E-2
5.315E-2
 5 266
23 C0007114 Malignant neoplasm of skin DisGeNET Curated 8.577E-5 2.394E-3 1.686E-2
5.506E-2
 5 268
24 C1411966 Clostridium; difficile (disorder) DisGeNET BeFree 9.101E-5 2.435E-3 1.715E-2
5.843E-2
 3 51
25 C0020456 Hyperglycemia DisGeNET Curated 9.937E-5 2.552E-3 1.797E-2
6.380E-2
 6 450
26 C1841972 Glucocorticoid Receptor Deficiency DisGeNET Curated 1.080E-4 2.667E-3 1.879E-2
6.935E-2
 3 54
27 C0553694 Oropharyngeal disorders DisGeNET BeFree 1.141E-4 2.714E-3 1.911E-2
7.327E-2
 3 55
28 C0002893 Refractory anemias DisGeNET Curated 1.223E-4 2.805E-3 1.975E-2
7.853E-2
 5 289
29 C0042345 Varicosity DisGeNET Curated 1.270E-4 2.811E-3 1.980E-2
8.153E-2
 3 57
30 C0023470 Myeloid Leukemia DisGeNET Curated 1.481E-4 3.170E-3 2.233E-2
9.510E-2
 6 484
31 C3714636 Pneumonitis DisGeNET BeFree 1.673E-4 3.464E-3 2.440E-2
1.074E-1
 5 309
32 C0751713 Inclusion Body Myopathy, Sporadic DisGeNET BeFree 1.794E-4 3.599E-3 2.534E-2
1.152E-1
 3 64
33 C0016063 Osteitis Fibrosa Disseminata DisGeNET Curated 1.880E-4 3.657E-3 2.576E-2
1.207E-1
 2 12
34 C0080178 Spina Bifida DisGeNET Curated 2.055E-4 3.881E-3 2.733E-2
1.319E-1
 3 67
35 C1266127 Histiocytoma, Angiomatoid Fibrous DisGeNET Curated 2.219E-4 3.958E-3 2.787E-2
1.425E-1
 2 13
36 C0018843 Heat Stroke DisGeNET Curated 2.219E-4 3.958E-3 2.787E-2
1.425E-1
 2 13
37 C0029401 Osteitis Deformans DisGeNET Curated 2.650E-4 4.598E-3 3.238E-2
1.701E-1
 3 73
38 C0278488 Carcinoma breast stage IV DisGeNET BeFree 4.898E-4 8.275E-3
5.828E-2
3.145E-1
 5 390
39 C0034067 Pulmonary Emphysema DisGeNET Curated 5.514E-4 8.946E-3
6.301E-2
3.540E-1
 4 223
40 C0699949 airway disease DisGeNET BeFree 5.574E-4 8.946E-3
6.301E-2
3.579E-1
 3 94
41 C0349636 Pre B-cell acute lymphoblastic leukemia DisGeNET BeFree 5.924E-4 9.277E-3
6.533E-2
3.803E-1
 2 21
42 C0917798 Cerebral Ischemia DisGeNET Curated 6.502E-4 9.938E-3
6.999E-2
4.174E-1
 4 233
43 C0238462 Medullary carcinoma of thyroid DisGeNET Curated 6.821E-4 1.010E-2
7.116E-2
4.379E-1
 4 236
44 C0334299 Carcinoid tumor no ICD-O subtype DisGeNET BeFree 7.074E-4 1.010E-2
7.116E-2
4.542E-1
 3 102
45 C0027765 nervous system disorder DisGeNET Curated 7.083E-4 1.010E-2
7.116E-2
4.547E-1
 5 423
46 C0037286 Skin Neoplasms DisGeNET Curated 7.264E-4 1.014E-2
7.140E-2
4.664E-1
 4 240
47 C0003507 Aortic Valve Stenosis DisGeNET Curated 8.353E-4 1.104E-2
7.776E-2
5.363E-1
 3 108
48 C0236736 Cocaine-Related Disorders DisGeNET Curated 8.353E-4 1.104E-2
7.776E-2
5.363E-1
 3 108
49 C0024517 Single major depressive episode DisGeNET Curated 8.427E-4 1.104E-2
7.776E-2
5.410E-1
 2 25
50 C1868682 Paroxysmal kinesigenic choreoathetosis DisGeNET Curated 9.045E-4 1.161E-2
8.179E-2
5.807E-1
 3 111
Show 45 more annotations