Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc155_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 28 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004252 serine-type endopeptidase activity 9.605E-10 1.966E-8 7.722E-8 2.689E-8 6 215
2 GO:0008236 serine-type peptidase activity 1.957E-9 1.966E-8 7.722E-8 5.478E-8 6 242
3 GO:0017171 serine hydrolase activity 2.107E-9 1.966E-8 7.722E-8 5.899E-8 6 245
4 GO:0004175 endopeptidase activity 8.692E-8 6.085E-7 2.390E-6 2.434E-6 6 457
5 GO:0043008 ATP-dependent protein binding 1.418E-5 7.940E-5 3.118E-4 3.970E-4 2 10
6 GO:0031708 endothelin B receptor binding 1.767E-3 8.248E-3 3.239E-2 4.949E-2 1 3
7 GO:0031705 bombesin receptor binding 2.356E-3 9.424E-3 3.701E-2
6.597E-2
 1 4
8 GO:0005521 lamin binding 9.978E-3 3.492E-2
1.371E-1
2.794E-1
 1 17
Show 3 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 373 annotations before applied cutoff / 18623 genes in category

No results to display

3: GO: Cellular Component [Display Chart] 11 input genes in category / 33 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 5 input genes in category / 576 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000143 Rectovaginal fistula 4.997E-4 4.530E-2
3.141E-1
2.878E-1
 2 34
2 HP:0002025 Anal stenosis 8.012E-4 4.530E-2
3.141E-1
4.615E-1
 2 43
3 HP:0100590 Rectal fistula 8.776E-4 4.530E-2
3.141E-1
5.055E-1
 2 45
4 HP:0004320 Vaginal fistula 9.575E-4 4.530E-2
3.141E-1
5.515E-1
 2 47
5 HP:0100819 Intestinal fistula 9.575E-4 4.530E-2
3.141E-1
5.515E-1
 2 47
6 HP:0030241 Hypoplasia of deltoid muscle 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
7 HP:0008953 Pectoralis major hypoplasia 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
8 HP:0040289 Cyclic neutropenia 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
9 HP:0008998 Pectoralis hypoplasia 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
10 HP:0006790 Cerebral cortex with spongiform changes 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
11 HP:0002549 Deficit in phonologic short-term memory 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
12 HP:0009016 Upper limb muscle hypoplasia 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
13 HP:0008588 Slit-like opening of the exterior auditory meatus 1.062E-3 4.530E-2
3.141E-1
6.119E-1
 1 1
14 HP:0009131 Abnormality of the musculature of the thorax 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
15 HP:0040264 Jaw pain 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
16 HP:0007158 Progressive extrapyramidal muscular rigidity 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
17 HP:0010846 EEG with persistent abnormal rhythmic activity 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
18 HP:0003657 Granular osmiophilic deposits (GROD) in cells 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
19 HP:0011099 Spastic hemiparesis 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
20 HP:0006064 Limited interphalangeal movement 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
21 HP:0025152 Poor visual behavior for age 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
22 HP:0100292 Amyloidosis of peripheral nerves 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
23 HP:0011957 Abnormality of the pectoral muscle 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
24 HP:0005327 Loss of facial expression 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
25 HP:0000542 Impaired ocular adduction 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
26 HP:0000619 Impaired convergence 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
27 HP:0002528 Granulovacuolar degeneration 2.124E-3 4.530E-2
3.141E-1
1.000E0
 1 2
28 HP:0001464 Aplasia/Hypoplasia involving the shoulder musculature 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
29 HP:0007017 Progressive forgetfulness 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
30 HP:0012672 Akinetic mutism 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
31 HP:0010048 Aplasia of metacarpal bones 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
32 HP:0000747 Forgetfulness 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
33 HP:0007076 Extrapyramidal muscular rigidity 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
34 HP:0006999 Basal ganglia gliosis 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
35 HP:0008952 Shoulder muscle hypoplasia 3.184E-3 4.846E-2
3.360E-1
1.000E0
 1 3
36 HP:0100589 Urogenital fistula 3.483E-3 4.846E-2
3.360E-1
1.000E0
 2 90
37 HP:0008713 Genitourinary tract malformation 3.483E-3 4.846E-2
3.360E-1
1.000E0
 2 90
38 HP:0010542 Vestibular nystagmus 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
39 HP:0001467 Aplasia/Hypoplasia involving the musculature of the upper limbs 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
40 HP:0009128 Aplasia/Hypoplasia involving the musculature of the extremities 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
41 HP:0005541 Congenital agranulocytosis 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
42 HP:0004059 Radial club hand 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
43 HP:0006943 Diffuse spongiform leukoencephalopathy 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
44 HP:0011176 EEG with constitutional variants 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
45 HP:0003226 Rectilinear intracellular accumulation of autofluorescent lipopigment storage material 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
46 HP:0000661 Palpebral fissure narrowing on adduction 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
47 HP:0007183 Focal T2 hyperintense basal ganglia lesion 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
48 HP:0008765 Auditory hallucinations 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
49 HP:0010663 Abnormality of thalamus morphology 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
50 HP:0012751 Abnormal basal ganglia MRI signal intensity 4.244E-3 4.846E-2
3.360E-1
1.000E0
 1 4
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 353 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001048 absent enteric neurons 8.381E-6 2.959E-3 1.907E-2 2.959E-3 2 10
2 MP:0006326 conductive hearing impairment 2.845E-5 5.022E-3 3.237E-2 1.004E-2 2 18
3 MP:0002731 megacolon 7.016E-5 8.255E-3
5.321E-2
 2.477E-2 2 28
4 MP:0001046 abnormal enteric neuron morphology 9.790E-5 8.640E-3
5.569E-2
 3.456E-2 2 33
5 MP:0001044 abnormal enteric nervous system morphology 1.671E-4 1.180E-2
7.604E-2
5.899E-2
 2 43
6 MP:0009098 anovaginal fistula 4.829E-4 2.841E-2
1.831E-1
1.704E-1
 1 1
7 MP:0004638 elongated metacarpal bones 9.655E-4 3.407E-2
2.196E-1
3.408E-1
 1 2
8 MP:0005364 increased susceptibility to prion infection 9.655E-4 3.407E-2
2.196E-1
3.408E-1
 1 2
9 MP:0011214 increased brain copper level 9.655E-4 3.407E-2
2.196E-1
3.408E-1
 1 2
10 MP:0011149 abnormal hippocampus stratum lacunosum morphology 9.655E-4 3.407E-2
2.196E-1
3.408E-1
 1 2
11 MP:0002751 abnormal autonomic nervous system morphology 1.238E-3 3.407E-2
2.196E-1
4.370E-1
 2 117
12 MP:0005202 lethargy 1.573E-3 3.407E-2
2.196E-1
5.552E-1
 2 132
13 MP:0001523 impaired righting response 1.693E-3 3.407E-2
2.196E-1
5.976E-1
 2 137
14 MP:0000495 abnormal colon morphology 1.717E-3 3.407E-2
2.196E-1
6.063E-1
 2 138
15 MP:0030862 absent triquetrum 1.930E-3 3.407E-2
2.196E-1
6.814E-1
 1 4
16 MP:0003129 persistent cloaca 1.930E-3 3.407E-2
2.196E-1
6.814E-1
 1 4
17 MP:0011215 decreased brain copper level 1.930E-3 3.407E-2
2.196E-1
6.814E-1
 1 4
18 MP:0008232 abnormal cingulum morphology 1.930E-3 3.407E-2
2.196E-1
6.814E-1
 1 4
19 MP:0003314 dysmetria 1.930E-3 3.407E-2
2.196E-1
6.814E-1
 1 4
20 MP:0005363 decreased susceptibility to prion infection 1.930E-3 3.407E-2
2.196E-1
6.814E-1
 1 4
21 MP:0002862 altered righting response 2.161E-3 3.412E-2
2.199E-1
7.629E-1
 2 155
22 MP:0020187 altered susceptibility to prion infection 2.412E-3 3.412E-2
2.199E-1
8.516E-1
 1 5
23 MP:0030861 abnormal triquetrum morphology 2.412E-3 3.412E-2
2.199E-1
8.516E-1
 1 5
24 MP:0011213 abnormal brain copper level 2.412E-3 3.412E-2
2.199E-1
8.516E-1
 1 5
25 MP:0002980 abnormal postural reflex 2.416E-3 3.412E-2
2.199E-1
8.529E-1
 2 164
26 MP:0009052 anal stenosis 2.894E-3 3.649E-2
2.352E-1
1.000E0
 1 6
27 MP:0003695 delayed blastocyst hatching from the zona pellucida 2.894E-3 3.649E-2
2.352E-1
1.000E0
 1 6
28 MP:0030410 middle ear effusion 2.894E-3 3.649E-2
2.352E-1
1.000E0
 1 6
29 MP:0002409 decreased susceptibility to infection 3.468E-3 4.221E-2
2.720E-1
1.000E0
 2 197
30 MP:0012739 abnormal anterior primitive streak morphology 3.858E-3 4.297E-2
2.769E-1
1.000E0
 1 8
31 MP:0002911 abnormal inhibitory postsynaptic potential 3.858E-3 4.297E-2
2.769E-1
1.000E0
 1 8
32 MP:0006325 impaired hearing 3.895E-3 4.297E-2
2.769E-1
1.000E0
 2 209
33 MP:0000489 abnormal large intestine morphology 4.080E-3 4.364E-2
2.813E-1
1.000E0
 2 214
34 MP:0004032 abnormal interventricular groove morphology 4.339E-3 4.505E-2
2.903E-1
1.000E0
 1 9
35 MP:0001714 absent trophoblast giant cells 4.820E-3 4.726E-2
3.046E-1
1.000E0
 1 10
36 MP:0002926 aganglionic megacolon 4.820E-3 4.726E-2
3.046E-1
1.000E0
 1 10
37 MP:0011189 small embryonic epiblast 5.301E-3 4.760E-2
3.068E-1
1.000E0
 1 11
38 MP:0000555 absent carpal bone 5.301E-3 4.760E-2
3.068E-1
1.000E0
 1 11
39 MP:0030154 abnormal tympanic cavity morphology 5.782E-3 4.760E-2
3.068E-1
1.000E0
 1 12
40 MP:0010132 decreased DN2 thymocyte number 5.782E-3 4.760E-2
3.068E-1
1.000E0
 1 12
41 MP:0003952 abnormal copper level 5.782E-3 4.760E-2
3.068E-1
1.000E0
 1 12
42 MP:0003951 abnormal copper homeostasis 6.263E-3 4.760E-2
3.068E-1
1.000E0
 1 13
43 MP:0011183 abnormal primitive endoderm morphology 6.263E-3 4.760E-2
3.068E-1
1.000E0
 1 13
44 MP:0003130 anal atresia 6.263E-3 4.760E-2
3.068E-1
1.000E0
 1 13
45 MP:0010072 increased pruritus 6.263E-3 4.760E-2
3.068E-1
1.000E0
 1 13
46 MP:0010133 increased DN3 thymocyte number 6.263E-3 4.760E-2
3.068E-1
1.000E0
 1 13
47 MP:0001513 limb grasping 6.338E-3 4.760E-2
3.068E-1
1.000E0
 2 268
48 MP:0004838 abnormal neural fold elevation formation 6.743E-3 4.959E-2
3.196E-1
1.000E0
 1 14
Show 43 more annotations

6: Domain [Display Chart] 11 input genes in category / 41 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR033116 TRYPSIN SER InterPro 4.702E-12 1.306E-10 5.618E-10 1.928E-10 6 90
2 IPR018114 TRYPSIN HIS InterPro 1.077E-11 1.306E-10 5.618E-10 4.414E-10 6 103
3 PS00135 TRYPSIN SER PROSITE 1.283E-11 1.306E-10 5.618E-10 5.262E-10 6 106
4 PS00134 TRYPSIN HIS PROSITE 1.359E-11 1.306E-10 5.618E-10 5.574E-10 6 107
5 IPR001314 Peptidase S1A InterPro 1.898E-11 1.306E-10 5.618E-10 7.781E-10 6 113
6 PS50240 TRYPSIN DOM PROSITE 2.113E-11 1.306E-10 5.618E-10 8.662E-10 6 115
7 SM00020 Tryp SPc SMART 2.347E-11 1.306E-10 5.618E-10 9.624E-10 6 117
8 PF00089 Trypsin Pfam 2.882E-11 1.306E-10 5.618E-10 1.181E-9 6 121
9 IPR001254 Trypsin dom InterPro 2.882E-11 1.306E-10 5.618E-10 1.181E-9 6 121
10 IPR009003 Peptidase S1 PA InterPro 3.185E-11 1.306E-10 5.618E-10 1.306E-9 6 123
11 IPR002098 SVP I InterPro 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
12 PF11587 Prion bPrPp Pfam 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
13 SM00157 PRP SMART 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
14 PS00291 PRION 1 PROSITE 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
15 PF10511 Cementoin Pfam 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
16 PS00706 PRION 2 PROSITE 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
17 IPR019541 Trappin transglut-bd rpt InterPro 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
18 IPR025860 Prion N dom InterPro 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
19 PS00313 SVP I PROSITE 5.871E-4 1.267E-3 5.452E-3 2.407E-2 1 1
20 PF00377 Prion Pfam 1.174E-3 2.093E-3 9.005E-3 4.813E-2 1 2
21 IPR000817 Prion InterPro 1.174E-3 2.093E-3 9.005E-3 4.813E-2 1 2
22 IPR022416 Prion/Doppel prot b-ribbon dom InterPro 1.174E-3 2.093E-3 9.005E-3 4.813E-2 1 2
23 1.10.790.10 - Gene3D 1.174E-3 2.093E-3 9.005E-3 4.813E-2 1 2
24 PF00322 Endothelin Pfam 1.760E-3 2.489E-3 1.071E-2
7.218E-2
 1 3
25 SM00272 END SMART 1.760E-3 2.489E-3 1.071E-2
7.218E-2
 1 3
26 IPR020475 Bibrotoxin/Sarafotoxin-D InterPro 1.760E-3 2.489E-3 1.071E-2
7.218E-2
 1 3
27 IPR001928 Endothln-like toxin InterPro 1.760E-3 2.489E-3 1.071E-2
7.218E-2
 1 3
28 PS00270 ENDOTHELIN PROSITE 1.760E-3 2.489E-3 1.071E-2
7.218E-2
 1 3
29 IPR019764 Endothelin toxin CS InterPro 1.760E-3 2.489E-3 1.071E-2
7.218E-2
 1 3
30 PF00095 WAP Pfam 9.357E-3 1.235E-2
5.313E-2
3.836E-1
 1 16
31 SM00217 WAP SMART 9.357E-3 1.235E-2
5.313E-2
3.836E-1
 1 16
32 4.10.75.10 - Gene3D 9.939E-3 1.235E-2
5.313E-2
4.075E-1
 1 17
33 PS51390 WAP PROSITE 9.939E-3 1.235E-2
5.313E-2
4.075E-1
 1 17
34 IPR008197 WAP dom InterPro 1.284E-2 1.549E-2
6.665E-2
5.266E-1
 1 22
35 IPR018253 DnaJ domain CS InterPro 1.574E-2 1.844E-2
7.935E-2
6.455E-1
 1 27
36 PF00226 DnaJ Pfam 2.783E-2 2.911E-2
1.253E-1
1.000E0
 1 48
37 PS50076 DNAJ 2 PROSITE 2.840E-2 2.911E-2
1.253E-1
1.000E0
 1 49
38 SM00271 DnaJ SMART 2.840E-2 2.911E-2
1.253E-1
1.000E0
 1 49
39 PS00636 DNAJ 1 PROSITE 2.840E-2 2.911E-2
1.253E-1
1.000E0
 1 49
40 1.10.287.110 - Gene3D 2.840E-2 2.911E-2
1.253E-1
1.000E0
 1 49
41 IPR001623 DnaJ domain InterPro 2.955E-2 2.955E-2
1.271E-1
1.000E0
 1 51
Show 36 more annotations

7: Pathway [Display Chart] 11 input genes in category / 39 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 2.642E-10 1.031E-8 4.383E-8 1.031E-8 7 238
2 172847 Protein digestion and absorption BioSystems: KEGG 8.107E-7 1.366E-5 5.812E-5 3.162E-5 4 90
3 169306 Pancreatic secretion BioSystems: KEGG 1.051E-6 1.366E-5 5.812E-5 4.099E-5 4 96
4 1457791 Formation of the cornified envelope BioSystems: REACTOME 1.706E-3 1.663E-2
7.075E-2
6.653E-2
 2 71
5 1457777 Antimicrobial peptides BioSystems: REACTOME 3.687E-3 2.876E-2
1.223E-1
1.438E-1
 2 105

8: Pubmed [Display Chart] 11 input genes in category / 2481 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3427074 Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Pubmed 1.777E-11 4.409E-8 3.701E-7 4.409E-8 3 3
2 27358403 Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. Pubmed 1.777E-10 2.204E-7 1.850E-6 4.408E-7 3 5
3 24793170 Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Pubmed 2.929E-9 2.422E-6 2.033E-5 7.266E-6 3 11
4 25195861 The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
5 27999401 Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
6 2826474 Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
7 18799464 Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
8 16327289 Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
9 8794736 Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
10 19197381 Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
11 2460440 Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
12 28187039 Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
13 3646943 Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. Pubmed 7.541E-8 1.439E-5 1.208E-4 1.871E-4 2 2
14 8864963 Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a]. Pubmed 2.262E-7 3.507E-5 2.944E-4 5.612E-4 2 3
15 1079736 The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin and elastase. Pubmed 2.262E-7 3.507E-5 2.944E-4 5.612E-4 2 3
16 9111002 Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments. Pubmed 2.262E-7 3.507E-5 2.944E-4 5.612E-4 2 3
17 6153632 Interaction between human pancreatic elastase and plasma protease inhibitors. Pubmed 4.523E-7 5.906E-5 4.958E-4 1.122E-3 2 4
18 20179351 Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. Pubmed 4.523E-7 5.906E-5 4.958E-4 1.122E-3 2 4
19 6191979 Radioimmunoassay of human pancreatic elastase 1. In vitro interaction of human pancreatic elastase 1 with serum protease inhibitors. Pubmed 4.523E-7 5.906E-5 4.958E-4 1.122E-3 2 4
20 12189154 Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). Pubmed 7.538E-7 9.350E-5 7.849E-4 1.870E-3 2 5
21 11961105 Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. Pubmed 1.130E-6 1.336E-4 1.121E-3 2.805E-3 2 6
22 20346360 Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. Pubmed 2.348E-6 2.648E-4 2.223E-3 5.826E-3 3 94
23 9851981 The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Pubmed 4.142E-6 4.468E-4 3.750E-3 1.028E-2 2 11
24 16518820 Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice. Pubmed 9.029E-6 4.664E-4 3.915E-3 2.240E-2 2 16
25 28071719 Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Pubmed 1.098E-5 4.664E-4 3.915E-3 2.723E-2 3 157
26 25063451 The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Pubmed 3.266E-5 4.664E-4 3.915E-3
8.103E-2
 2 30
27 15694261 Normal brain mitochondrial respiration in adult mice lacking cellular prion protein. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
28 28827331 Prion protein Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
29 15266305 Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
30 19820689 Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
31 12386336 Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
32 10679935 Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
33 1687385 The scrapie fibril protein and its cellular isoform. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
34 21478678 Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
35 8575772 Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
36 14610121 Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
37 22669942 Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
38 11704923 Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
39 10790216 Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
40 21350487 Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
41 16921242 Autopsy-proven Creutzfeldt-Jakob disease with a codon 180 mutation showing dissociation between diffusion-weighted magnetic resonance imaging and single-photon emission computed tomography findings: Is this a suggestive finding in long survival? Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
42 14657385 NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
43 15941909 Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
44 22032174 Long-time scale fluctuations of human prion protein determined by restrained MD simulations. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
45 20932979 Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
46 20921524 Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
47 17923484 High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
48 20453918 CSPalpha: the neuroprotective J protein. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
49 21597335 A Chinese Creutzfeldt-Jakob disease patient with E196K mutation in PRNP. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
50 26932165 Protective effects of elafin against adult asthma. Pubmed 2.880E-4 4.664E-4 3.915E-3
7.146E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 252 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PI3 PI3 interactions 4.303E-6 1.084E-3 6.623E-3 1.084E-3 2 6
2 int:LPA LPA interactions 1.575E-5 1.985E-3 1.212E-2 3.970E-3 2 11
3 int:CELA1 CELA1 interactions 7.874E-5 6.303E-3 3.850E-2 1.984E-2 2 24
4 int:SERPINB1 SERPINB1 interactions 1.000E-4 6.303E-3 3.850E-2 2.521E-2 2 27
5 int:SERPINA3 SERPINA3 interactions 2.562E-4 1.291E-2
7.886E-2
6.455E-2
 2 43
6 int:SERPINA1 SERPINA1 interactions 4.668E-4 1.960E-2
1.198E-1
1.176E-1
 2 58
7 int:HELZ HELZ interactions 6.413E-4 2.309E-2
1.410E-1
1.616E-1
 2 68
8 int:CELA3B CELA3B interactions 1.129E-3 3.557E-2
2.173E-1
2.846E-1
 1 2
9 int:GRN GRN interactions 1.380E-3 3.557E-2
2.173E-1
3.478E-1
 2 100
10 int:VRTN VRTN interactions 1.694E-3 3.557E-2
2.173E-1
4.268E-1
 1 3
11 int:CSF3 CSF3 interactions 1.694E-3 3.557E-2
2.173E-1
4.268E-1
 1 3
12 int:ADAM23 ADAM23 interactions 1.694E-3 3.557E-2
2.173E-1
4.268E-1
 1 3
13 int:MOG MOG interactions 2.258E-3 3.617E-2
2.210E-1
5.690E-1
 1 4
14 int:PTRH1 PTRH1 interactions 2.258E-3 3.617E-2
2.210E-1
5.690E-1
 1 4
15 int:CCDC149 CCDC149 interactions 2.822E-3 3.617E-2
2.210E-1
7.110E-1
 1 5
16 int:CADM3 CADM3 interactions 2.822E-3 3.617E-2
2.210E-1
7.110E-1
 1 5
17 int:ZBED3 ZBED3 interactions 2.822E-3 3.617E-2
2.210E-1
7.110E-1
 1 5
18 int:LSAMP LSAMP interactions 2.822E-3 3.617E-2
2.210E-1
7.110E-1
 1 5
19 int:SPARCL1 SPARCL1 interactions 2.822E-3 3.617E-2
2.210E-1
7.110E-1
 1 5
20 int:SERPIND1 SERPIND1 interactions 3.385E-3 3.617E-2
2.210E-1
8.530E-1
 1 6
21 int:EDN3 EDN3 interactions 3.385E-3 3.617E-2
2.210E-1
8.530E-1
 1 6
22 int:ZFYVE28 ZFYVE28 interactions 3.948E-3 3.617E-2
2.210E-1
9.949E-1
 1 7
23 int:NCAM2 NCAM2 interactions 3.948E-3 3.617E-2
2.210E-1
9.949E-1
 1 7
24 int:DYRK3 DYRK3 interactions 4.511E-3 3.617E-2
2.210E-1
1.000E0
 1 8
25 int:KEL KEL interactions 4.511E-3 3.617E-2
2.210E-1
1.000E0
 1 8
26 int:CAMP CAMP interactions 4.511E-3 3.617E-2
2.210E-1
1.000E0
 1 8
27 int:SALL3 SALL3 interactions 4.511E-3 3.617E-2
2.210E-1
1.000E0
 1 8
28 int:FGF13 FGF13 interactions 4.511E-3 3.617E-2
2.210E-1
1.000E0
 1 8
29 int:DPP6 DPP6 interactions 4.511E-3 3.617E-2
2.210E-1
1.000E0
 1 8
30 int:AIFM3 AIFM3 interactions 5.074E-3 3.617E-2
2.210E-1
1.000E0
 1 9
31 int:TSLP TSLP interactions 5.074E-3 3.617E-2
2.210E-1
1.000E0
 1 9
32 int:TBX5 TBX5 interactions 5.074E-3 3.617E-2
2.210E-1
1.000E0
 1 9
33 int:PDE10A PDE10A interactions 5.074E-3 3.617E-2
2.210E-1
1.000E0
 1 9
34 int:RPL41 RPL41 interactions 5.074E-3 3.617E-2
2.210E-1
1.000E0
 1 9
35 int:ZNF740 ZNF740 interactions 5.636E-3 3.617E-2
2.210E-1
1.000E0
 1 10
36 int:ARHGAP15 ARHGAP15 interactions 5.636E-3 3.617E-2
2.210E-1
1.000E0
 1 10
37 int:WDR5 WDR5 interactions 5.919E-3 3.617E-2
2.210E-1
1.000E0
 2 210
38 int:TYMSOS TYMSOS interactions 6.198E-3 3.617E-2
2.210E-1
1.000E0
 1 11
39 int:ERI3 ERI3 interactions 6.198E-3 3.617E-2
2.210E-1
1.000E0
 1 11
40 int:CSN3 CSN3 interactions 6.198E-3 3.617E-2
2.210E-1
1.000E0
 1 11
41 int:GRHL2 GRHL2 interactions 6.198E-3 3.617E-2
2.210E-1
1.000E0
 1 11
42 int:CMA1 CMA1 interactions 6.198E-3 3.617E-2
2.210E-1
1.000E0
 1 11
43 int:MRM2 MRM2 interactions 6.760E-3 3.617E-2
2.210E-1
1.000E0
 1 12
44 int:ADAP2 ADAP2 interactions 6.760E-3 3.617E-2
2.210E-1
1.000E0
 1 12
45 int:CXCL12 CXCL12 interactions 6.760E-3 3.617E-2
2.210E-1
1.000E0
 1 12
46 int:CXXC5 CXXC5 interactions 6.760E-3 3.617E-2
2.210E-1
1.000E0
 1 12
47 int:FAM27E3 FAM27E3 interactions 7.321E-3 3.617E-2
2.210E-1
1.000E0
 1 13
48 int:BAZ2B BAZ2B interactions 7.321E-3 3.617E-2
2.210E-1
1.000E0
 1 13
49 int:CELA3A CELA3A interactions 7.321E-3 3.617E-2
2.210E-1
1.000E0
 1 13
50 int:CTSE CTSE interactions 7.321E-3 3.617E-2
2.210E-1
1.000E0
 1 13
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p36.12 1p36.12 6.742E-5 6.067E-4 1.716E-3 6.067E-4 2 39
2 1p36.21 1p36.21 2.377E-4 1.070E-3 3.026E-3 2.139E-3 2 73
3 20q13.2-q13.3 20q13.2-q13.3 1.903E-3 5.708E-3 1.615E-2 1.713E-2 1 6
4 20q13.2 20q13.2 9.166E-3 2.062E-2
5.835E-2
8.250E-2
 1 29
5 20q13.12 20q13.12 2.200E-2 3.346E-2
9.466E-2
1.980E-1
 1 70
6 12q13 12q13 2.231E-2 3.346E-2
9.466E-2
2.008E-1
 1 71
7 20q13.33 20q13.33 2.758E-2 3.546E-2
1.003E-1
2.482E-1
 1 88
8 20p13 20p13 3.190E-2 3.589E-2
1.015E-1
2.871E-1
 1 102
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 31 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2A Q2 V$E2A Q2 5.527E-3 3.984E-2
1.604E-1
1.713E-1
 2 193
2 V$MYOD Q6 01 V$MYOD Q6 01 5.639E-3 3.984E-2
1.604E-1
1.748E-1
 2 195
3 V$MYOD 01 V$MYOD 01 6.217E-3 3.984E-2
1.604E-1
1.927E-1
 2 205
4 V$TAL1BETAE47 01 V$TAL1BETAE47 01 6.395E-3 3.984E-2
1.604E-1
1.982E-1
 2 208
5 V$GATA1 04 V$GATA1 04 6.455E-3 3.984E-2
1.604E-1
2.001E-1
 2 209
6 V$GATA1 05 V$GATA1 05 7.710E-3 3.984E-2
1.604E-1
2.390E-1
 2 229
Show 1 more annotation

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 361 WAP four-disulfide core domain containing genenames.org 4.937E-3 1.975E-2 4.115E-2 1.975E-2 1 18
2 584 DNAJ (HSP40) heat shock proteins genenames.org 1.340E-2 2.679E-2
5.581E-2
5.358E-2
 1 49

13: Coexpression [Display Chart] 11 input genes in category / 826 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18044827-Table2 Human Breast Bergamaschi08 278genes GeneSigDB 9.098E-8 7.515E-5 5.482E-4 7.515E-5 5 270
2 M18973 Genes within amplicon 20q12-q13 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.263E-7 2.174E-4 1.586E-3 4.347E-4 4 149
3 15701848-Table2 Human Stomach Yang05 96genes GeneSigDB 9.810E-6 2.701E-3 1.970E-2 8.103E-3 3 92
4 16421595-Table3 Human Ovarian LePage06 18genes GeneSigDB 2.457E-5 5.074E-3 3.701E-2 2.029E-2 2 16
5 M1478 Granule constituents expressed during mouse promyelocytic cell line differentiation to neutrophils. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.128E-5 9.137E-3
6.665E-2
5.062E-2
 2 25
6 M7581 Genes up-regulated in pancreatic cancer cells grown in orthotopic xenograft tumors compared to those grown in vitro. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.637E-5 9.137E-3
6.665E-2
5.482E-2
 2 26
7 M9295 Genes down-regulated in Lung dendritic cell from Ad5 T424A hexon infection wildtype mice versus Lung dendritic cell from Ad5 T424A hexon inf IL-1R mice. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 9.282E-3
6.771E-2
8.240E-2
 3 200
8 M3571 Genes down-regulated in comparison of wild type CD8 effector T cells at day 6 versus those from mice defficient for TRAF6 [GeneID=7189] at day 6. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 9.282E-3
6.771E-2
8.240E-2
 3 200
9 17210693-Table2 Human pancreas Fidler07 50genes InVivo GeneSigDB 1.011E-4 9.282E-3
6.771E-2
8.354E-2
 2 32
10 16651409-SuppTable4 Mouse StemCell Lawlor06 89genes GeneSigDB 4.205E-4 3.473E-2
2.534E-1
3.473E-1
 2 65
Show 5 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 741 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 pancreas pancreas Human Protein Atlas 1.334E-10 9.888E-8 7.105E-7 9.888E-8 5 70
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas Tabula Muris Consortium 1.540E-6 5.704E-4 4.099E-3 1.141E-3 4 184
3 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic acinar cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic acinar cell Tabula Muris Consortium 1.020E-5 2.520E-3 1.811E-2 7.561E-3 3 88
4 Facebase ST1 Univ 500 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 FaceBase_ST1 4.272E-5 7.915E-3
5.687E-2
 3.166E-2 4 427
5 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic ductal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic ductal cell Tabula Muris Consortium 9.704E-5 1.438E-2
1.033E-1
7.191E-2
 3 187
6 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 1.292E-4 1.596E-2
1.147E-1
9.577E-2
 3 206
7 gudmap developingGonad e12.5 testes k2 500 DevelopingGonad e12.5 testes emap-29069 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.061E-4 2.182E-2
1.568E-1
1.527E-1
 2 43
8 gudmap developingGonad e12.5 epididymis k4 500 DevelopingGonad e12.5 epididymis emap-29139 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.361E-4 2.187E-2
1.571E-1
1.749E-1
 2 46
9 gudmap developingGonad e12.5 testes k3 1000 DevelopingGonad e12.5 testes emap-29069 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.014E-4 4.128E-2
2.966E-1
3.715E-1
 2 67
Show 4 more annotations

15: Computational [Display Chart] 8 input genes in category / 52 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5062 GNF2 SERPINI2 Neighborhood of SERPINI2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.081E-9 1.082E-7 4.911E-7 1.082E-7 4 25
2 M13003 MODULE 109 Serine proteases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.347E-8 3.503E-7 1.590E-6 7.006E-7 4 39
3 M8706 GNF2 SPINK1 Neighborhood of SPINK1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.636E-7 1.670E-5 7.579E-5 5.011E-5 3 27

16: MicroRNA [Display Chart] 11 input genes in category / 149 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-638:mirSVR highEffct hsa-miR-638:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.129E-5 7.404E-3 4.135E-2 9.132E-3 2 77
2 hsa-miR-196b*:mirSVR highEffct hsa-miR-196b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.939E-5 7.404E-3 4.135E-2 1.481E-2 2 98
3 AGTGCGT,MIR-521:MSigDB AGTGCGT,MIR-521:MSigDB MSigDB 9.133E-4 4.536E-2
2.533E-1
1.361E-1
 1 6

17: Drug [Display Chart] 11 input genes in category / 2161 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000194288 AC1Q4I5I Stitch 2.911E-14 6.290E-11 5.193E-10 6.290E-11 4 4
2 CID000003211 AC1Q6PMM Stitch 5.826E-12 6.295E-9 5.197E-8 1.259E-8 5 40
3 CID005493639 AC1NUUB8 Stitch 1.039E-9 7.488E-7 6.182E-6 2.246E-6 4 32
4 CID000493598 AC1LAR7G Stitch 2.921E-9 1.578E-6 1.303E-5 6.312E-6 4 41
5 CID000002004 ATEE Stitch 5.137E-9 2.220E-6 1.833E-5 1.110E-5 4 47
6 CID000059911 AC1Q3O4D Stitch 6.969E-9 2.510E-6 2.072E-5 1.506E-5 3 9
7 CID010390162 MeOSuc-Ala-Ala-Pro-Ala-CMK Stitch 1.824E-8 5.630E-6 4.648E-5 3.941E-5 3 12
8 CID004252643 N-methoxysuccinyl-Ala-Ala-Pro-Val Stitch 3.016E-8 8.146E-6 6.725E-5 6.517E-5 3 14
9 CID000004373 HLE inhibitor Stitch 8.018E-8 1.519E-5 1.254E-4 1.733E-4 3 19
10 CID000004784 phenylmethylsulfonyl fluoride Stitch 8.507E-8 1.519E-5 1.254E-4 1.838E-4 5 263
11 CID005487661 Glt(ala)(3)nhet Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
12 CID006439875 Uaaapne Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
13 CID000196795 Abe-cic Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
14 CID004172141 N-acetyl-Ala-Ala-Ala Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
15 CID000065729 u-1-6-2 Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
16 CID000126376 AC1Q6JOW Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
17 CID000064552 Ascb-lys-ala-val Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
18 CID000133907 2-Trifluoroacetamidobenzenesulfonyl fluoride Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
19 CID000064783 pseudosaccharin chloride Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
20 CID000073120 bromochlorophenol blue Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
21 CID005478947 AC1NUHMJ Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
22 CID005490177 AAPACK Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
23 CID000171308 oxyphysodic acid Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
24 CID000386212 ilicic acid Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
25 CID003488064 4-oxoazetidine-2-carboxylate Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
26 CID000568818 aa 199 Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
27 CID000195319 DFKi Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
28 CID000136413 dibenzamide Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
29 CID000179640 decarine Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
30 CID005281860 3,4,3'-tri-O-methylellagic acid Stitch 2.109E-7 1.519E-5 1.254E-4 4.557E-4 2 2
31 CID000005936 diisopropylfluorophosphate Stitch 2.291E-7 1.597E-5 1.318E-4 4.950E-4 5 321
32 CID000017559 brilliant blue Stitch 2.415E-7 1.631E-5 1.346E-4 5.219E-4 3 27
33 CID000129938 AC1L2WHQ Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
34 CID000149069 AGN 190383 Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
35 CID000164950 robustine Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
36 CID005489523 Tfa-phe-ala Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
37 CID000216222 florifenine Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
38 CID006443645 Ol-ala-ala-pro-val Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
39 CID005487372 Mdl 27399 Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
40 CID005748391 CAAPV Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
41 CID000127267 Stlpn Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
42 CID005354274 AC1NS5A4 Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
43 CID000155664 Z-Phe-Ala-DMK Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
44 CID000304271 4-thiazolecarboxylic acid Stitch 6.324E-7 3.106E-5 2.564E-4 1.367E-3 2 3
45 CID000107475 Val-Val Stitch 7.522E-7 3.612E-5 2.982E-4 1.626E-3 3 39
46 CID000107706 sivelestat Stitch 8.769E-7 4.120E-5 3.401E-4 1.895E-3 3 41
47 CID000591073 K df Stitch 1.264E-6 4.270E-5 3.525E-4 2.732E-3 2 4
48 CID004608426 AC1NDXCO Stitch 1.264E-6 4.270E-5 3.525E-4 2.732E-3 2 4
49 CID000089682 mPse Stitch 1.264E-6 4.270E-5 3.525E-4 2.732E-3 2 4
50 CID006474904 L-696,475 Stitch 1.264E-6 4.270E-5 3.525E-4 2.732E-3 2 4
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 453 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0026633 Mouth Abnormalities DisGeNET Curated 2.487E-5 6.451E-3 4.318E-2 1.126E-2 2 14
2 C0265962 Ichthyosis linearis circumflexa DisGeNET Curated 1.524E-4 6.451E-3 4.318E-2
6.904E-2
 2 34
3 C3150975 HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 4 DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
4 C1327918 Oculootoradial syndrome DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
5 C1623209 Okihiro Syndrome DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
6 C1847609 Deficit in phonologic short-term memory DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
7 OMIN:607323 DUANE-RADIAL RAY SYNDROME; DRRS OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
8 cv:C0221023 Cyclical neutropenia Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
9 C0751645 Human Transmissible Spongiform Encephalopathies, Inherited DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
10 C1852470 Extrapyramidal muscular rigidity DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
11 cv:C2750457 Waardenburg syndrome type 4B Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
12 cv:C3150975 Hirschsprung disease 4 Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
13 C2931022 Amyloidosis, Cerebral, with Spongiform Encephalopathy DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
14 C4275003 Familial Creutzfeldt-Jakob DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
15 cv:C0017495 Gerstmann-Straussler-Scheinker syndrome Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
16 OMIN:245300 KURU, SUSCEPTIBILITY TO OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
17 OMIN:606688 SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
18 C0262424 CNS DEGENERATION DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
19 cv:C1864112 Huntington disease-like 1 Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
20 OMIN:603218 HUNTINGTON DISEASE-LIKE 1; HDL1 OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
21 C0022802 Kuru DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
22 OMIN:613265 WAARDENBURG SYNDROME, TYPE 4B; WS4B OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
23 OMIN:137440 GERSTMANN-STRAUSSLER DISEASE; GSD OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
24 OMIN:147750 IVIC SYNDROME OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
25 C1852476 Loss of facial expression DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
26 cv:C1859966 Severe congenital neutropenia autosomal dominant Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
27 C0403483 Renal ocular syndrome DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
28 C0554119 Pancreatic malabsorption DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
29 cv:C1847650 Spongiform encephalopathy with neuropsychiatric features Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
30 C1847650 SPONGIFORM ENCEPHALOPATHY WITH NEUROPSYCHIATRIC FEATURES DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
31 C1864112 HUNTINGTON DISEASE-LIKE 1 DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
32 C0333157 Colloid Cysts DisGeNET BeFree 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
33 cv:C0206042 Fatal familial insomnia Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
34 cv:C1855588 Kuru, susceptibility to Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
35 OMIN:600072 FATAL FAMILIAL INSOMNIA; FFI OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
36 OMIN:162800 CYCLIC HEMATOPOIESIS OMIM 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
37 cv:C1623209 Duane-radial ray syndrome Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
38 C2750457 Waardenburg Syndrome, Type 4b DisGeNET Curated 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
39 cv:C1327918 IVIC syndrome Clinical Variations 5.554E-4 6.451E-3 4.318E-2
2.516E-1
 1 1
40 C0020458 Hyperhidrosis disorder DisGeNET Curated 9.116E-4 9.316E-3
6.236E-2
4.129E-1
 2 83
41 C0700590 Increased sweating DisGeNET Curated 9.116E-4 9.316E-3
6.236E-2
4.129E-1
 2 83
42 C0038990 Sweating DisGeNET Curated 9.116E-4 9.316E-3
6.236E-2
4.129E-1
 2 83
43 C1274789 Ligneous conjunctivitis DisGeNET Curated 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
44 C0009946 Conversion disorder DisGeNET BeFree 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
45 C0236000 Jaw pain DisGeNET Curated 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
46 C1834207 Ceroid Lipofuscinosis, Neuronal, Parry Type DisGeNET Curated 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
47 C0520789 Progressive subcortical gliosis DisGeNET BeFree 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
48 C0393547 Bulbospinal Neuronopathy DisGeNET Curated 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
49 C1135993 Wasting Disease, Chronic DisGeNET BeFree 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
50 cv:C0022336 Jakob-Creutzfeldt disease Clinical Variations 1.110E-3 9.316E-3
6.236E-2
5.031E-1
 1 2
Show 45 more annotations