Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc15_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 28 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005200 structural constituent of cytoskeleton 7.264E-15 2.034E-13 7.988E-13 2.034E-13 7 110
2 GO:0003779 actin binding 4.661E-13 6.525E-12 2.562E-11 1.305E-11 8 412
3 GO:0030507 spectrin binding 1.340E-12 1.250E-11 4.911E-11 3.751E-11 5 32
4 GO:0005088 Ras guanyl-nucleotide exchange factor activity 2.819E-10 1.973E-9 7.749E-9 7.892E-9 6 232
5 GO:0005085 guanyl-nucleotide exchange factor activity 1.492E-9 8.357E-9 3.282E-8 4.178E-8 6 306
6 GO:0005516 calmodulin binding 1.261E-6 5.883E-6 2.310E-5 3.530E-5 4 190
7 GO:0005543 phospholipid binding 2.071E-5 8.283E-5 3.253E-4 5.798E-4 4 385
8 GO:0051015 actin filament binding 2.817E-5 9.860E-5 3.872E-4 7.888E-4 3 132
9 GO:0030506 ankyrin binding 4.322E-5 1.344E-4 5.280E-4 1.210E-3 2 21
10 GO:0032029 myosin tail binding 9.644E-4 2.700E-3 1.060E-2 2.700E-2 1 2
11 GO:0002046 opsin binding 1.928E-3 4.907E-3 1.927E-2
5.398E-2
 1 4
12 GO:0045505 dynein intermediate chain binding 2.891E-3 6.745E-3 2.649E-2
8.094E-2
 1 6
13 GO:0034452 dynactin binding 3.853E-3 8.298E-3 3.259E-2
1.079E-1
 1 8
14 GO:0003810 protein-glutamine gamma-glutamyltransferase activity 4.333E-3 8.666E-3 3.403E-2
1.213E-1
 1 9
15 GO:0032036 myosin heavy chain binding 6.733E-3 1.257E-2 4.936E-2
1.885E-1
 1 14
16 GO:0005545 1-phosphatidylinositol binding 1.056E-2 1.848E-2
7.259E-2
2.958E-1
 1 22
17 GO:0016755 transferase activity, transferring amino-acyl groups 1.247E-2 2.054E-2
8.068E-2
3.492E-1
 1 26
18 GO:0019894 kinesin binding 2.008E-2 3.123E-2
1.227E-1
5.622E-1
 1 42
19 GO:0043621 protein self-association 2.669E-2 3.934E-2
1.545E-1
7.474E-1
 1 56
20 GO:0017022 myosin binding 3.233E-2 4.526E-2
1.777E-1
9.052E-1
 1 68
Show 15 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 220 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051693 actin filament capping 3.586E-18 7.888E-16 4.712E-15 7.888E-16 7 39
2 GO:0030835 negative regulation of actin filament depolymerization 8.929E-18 9.822E-16 5.867E-15 1.964E-15 7 44
3 GO:0030837 negative regulation of actin filament polymerization 3.115E-17 2.267E-15 1.354E-14 6.853E-15 7 52
4 GO:0030834 regulation of actin filament depolymerization 4.123E-17 2.267E-15 1.354E-14 9.070E-15 7 54
5 GO:0030042 actin filament depolymerization 6.997E-17 3.079E-15 1.839E-14 1.539E-14 7 58
6 GO:0032272 negative regulation of protein polymerization 1.287E-16 4.718E-15 2.818E-14 2.831E-14 7 63
7 GO:1901880 negative regulation of protein depolymerization 2.022E-16 6.355E-15 3.796E-14 4.448E-14 7 67
8 GO:0043242 negative regulation of protein complex disassembly 2.786E-16 7.662E-15 4.577E-14 6.130E-14 7 70
9 GO:1901879 regulation of protein depolymerization 9.639E-16 2.356E-14 1.407E-13 2.121E-13 7 83
10 GO:0043244 regulation of protein complex disassembly 2.978E-15 6.552E-14 3.914E-13 6.552E-13 7 97
11 GO:0051261 protein depolymerization 6.900E-15 1.380E-13 8.243E-13 1.518E-12 7 109
12 GO:0031333 negative regulation of protein complex assembly 1.376E-14 2.523E-13 1.507E-12 3.028E-12 7 120
13 GO:0051494 negative regulation of cytoskeleton organization 2.442E-14 4.132E-13 2.468E-12 5.371E-12 7 130
14 GO:0030833 regulation of actin filament polymerization 6.165E-14 9.688E-13 5.787E-12 1.356E-11 7 148
15 GO:0030041 actin filament polymerization 1.281E-13 1.879E-12 1.122E-11 2.818E-11 7 164
16 GO:0008064 regulation of actin polymerization or depolymerization 1.521E-13 2.053E-12 1.226E-11 3.345E-11 7 168
17 GO:0030832 regulation of actin filament length 1.586E-13 2.053E-12 1.226E-11 3.490E-11 7 169
18 GO:0032271 regulation of protein polymerization 2.792E-13 3.413E-12 2.038E-11 6.143E-11 7 183
19 GO:0008154 actin polymerization or depolymerization 3.926E-13 4.546E-12 2.715E-11 8.637E-11 7 192
20 GO:0043624 cellular protein complex disassembly 8.192E-13 9.011E-12 5.383E-11 1.802E-10 7 213
21 GO:0051258 protein polymerization 2.080E-12 2.179E-11 1.302E-10 4.577E-10 7 243
22 GO:0032984 protein-containing complex disassembly 5.377E-12 5.377E-11 3.212E-10 1.183E-9 7 278
23 GO:0032956 regulation of actin cytoskeleton organization 9.637E-12 9.218E-11 5.506E-10 2.120E-9 7 302
24 GO:0010639 negative regulation of organelle organization 2.085E-11 1.911E-10 1.141E-9 4.586E-9 7 337
25 GO:0032970 regulation of actin filament-based process 2.312E-11 2.035E-10 1.215E-9 5.087E-9 7 342
26 GO:0007015 actin filament organization 2.458E-11 2.080E-10 1.243E-9 5.409E-9 7 345
27 GO:0032535 regulation of cellular component size 4.584E-11 3.735E-10 2.231E-9 1.009E-8 7 377
28 GO:0006888 ER to Golgi vesicle-mediated transport 5.748E-11 4.516E-10 2.698E-9 1.265E-8 6 178
29 GO:0043254 regulation of protein complex assembly 6.946E-11 5.270E-10 3.148E-9 1.528E-8 7 400
30 GO:0051493 regulation of cytoskeleton organization 1.636E-10 1.200E-9 7.166E-9 3.599E-8 7 452
31 GO:0007411 axon guidance 3.501E-10 2.468E-9 1.474E-8 7.701E-8 6 240
32 GO:0097485 neuron projection guidance 3.589E-10 2.468E-9 1.474E-8 7.897E-8 6 241
33 GO:0048193 Golgi vesicle transport 2.843E-9 1.895E-8 1.132E-7 6.254E-7 6 340
34 GO:0007409 axonogenesis 2.100E-8 1.359E-7 8.118E-7 4.621E-6 6 475
35 GO:0032092 positive regulation of protein binding 7.033E-6 4.421E-5 2.641E-4 1.547E-3 3 83
36 GO:0008360 regulation of cell shape 3.989E-5 2.438E-4 1.456E-3 8.776E-3 3 148
37 GO:0051099 positive regulation of binding 4.320E-5 2.568E-4 1.534E-3 9.503E-3 3 152
38 GO:0043393 regulation of protein binding 8.928E-5 5.169E-4 3.087E-3 1.964E-2 3 194
39 GO:0007009 plasma membrane organization 2.958E-4 1.669E-3 9.968E-3
6.508E-2
 3 291
40 GO:0051098 regulation of binding 4.355E-4 2.395E-3 1.431E-2
9.581E-2
 3 332
41 GO:0030534 adult behavior 2.859E-3 1.517E-2
9.063E-2
6.290E-1
 2 170
42 GO:0007182 common-partner SMAD protein phosphorylation 2.897E-3 1.517E-2
9.063E-2
6.372E-1
 1 6
43 GO:0048469 cell maturation 3.061E-3 1.566E-2
9.354E-2
6.734E-1
 2 176
44 GO:0035264 multicellular organism growth 3.199E-3 1.599E-2
9.553E-2
7.037E-1
 2 180
45 GO:1900042 positive regulation of interleukin-2 secretion 3.379E-3 1.616E-2
9.652E-2
7.433E-1
 1 7
46 GO:0045162 clustering of voltage-gated sodium channels 3.379E-3 1.616E-2
9.652E-2
7.433E-1
 1 7
47 GO:0072659 protein localization to plasma membrane 4.947E-3 2.288E-2
1.367E-1
1.000E0
 2 225
48 GO:1990778 protein localization to cell periphery 5.033E-3 2.288E-2
1.367E-1
1.000E0
 2 227
49 GO:0007016 cytoskeletal anchoring at plasma membrane 5.305E-3 2.288E-2
1.367E-1
1.000E0
 1 11
50 GO:0010459 negative regulation of heart rate 5.305E-3 2.288E-2
1.367E-1
1.000E0
 1 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 67 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008091 spectrin 7.152E-24 4.792E-22 2.295E-21 4.792E-22 7 9
2 GO:0030863 cortical cytoskeleton 3.002E-18 1.006E-16 4.816E-16 2.011E-16 8 97
3 GO:0044448 cell cortex part 5.500E-17 1.228E-15 5.883E-15 3.685E-15 8 138
4 GO:0030864 cortical actin cytoskeleton 1.915E-16 3.208E-15 1.537E-14 1.283E-14 7 68
5 GO:0005938 cell cortex 1.152E-14 1.543E-13 7.392E-13 7.717E-13 8 266
6 GO:0099568 cytoplasmic region 5.816E-14 6.494E-13 3.110E-12 3.897E-12 8 325
7 GO:0015629 actin cytoskeleton 1.257E-12 1.203E-11 5.762E-11 8.421E-11 8 476
8 GO:0032437 cuticular plate 2.911E-10 2.438E-9 1.168E-8 1.950E-8 3 4
9 GO:0014731 spectrin-associated cytoskeleton 4.071E-9 3.031E-8 1.452E-7 2.728E-7 3 8
10 GO:0044304 main axon 4.640E-6 3.109E-5 1.489E-4 3.109E-4 3 74
11 GO:0033270 paranode region of axon 2.074E-5 1.263E-4 6.051E-4 1.390E-3 2 15
12 GO:0033267 axon part 3.296E-4 1.841E-3 8.815E-3 2.209E-2 3 309
13 GO:0030017 sarcomere 3.684E-3 1.628E-2
7.799E-2
2.468E-1
 2 198
14 GO:0043203 axon hillock 3.772E-3 1.628E-2
7.799E-2
2.527E-1
 1 8
15 GO:0008290 F-actin capping protein complex 4.242E-3 1.628E-2
7.799E-2
2.842E-1
 1 9
16 GO:0044449 contractile fiber part 4.327E-3 1.628E-2
7.799E-2
2.899E-1
 2 215
17 GO:0030016 myofibril 4.526E-3 1.628E-2
7.799E-2
3.032E-1
 2 220
18 GO:0045179 apical cortex 4.713E-3 1.628E-2
7.799E-2
3.158E-1
 1 10
19 GO:0014069 postsynaptic density 5.019E-3 1.628E-2
7.799E-2
3.363E-1
 2 232
20 GO:0099572 postsynaptic specialization 5.019E-3 1.628E-2
7.799E-2
3.363E-1
 2 232
21 GO:0043292 contractile fiber 5.104E-3 1.628E-2
7.799E-2
3.420E-1
 2 234
22 GO:0070852 cell body fiber 5.653E-3 1.641E-2
7.859E-2
3.787E-1
 1 12
23 GO:0060076 excitatory synapse 5.895E-3 1.641E-2
7.859E-2
3.950E-1
 2 252
24 GO:0005916 fascia adherens 6.123E-3 1.641E-2
7.859E-2
4.102E-1
 1 13
25 GO:0043194 axon initial segment 6.123E-3 1.641E-2
7.859E-2
4.102E-1
 1 13
26 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane 7.062E-3 1.820E-2
8.715E-2
4.731E-1
 1 15
27 GO:0033268 node of Ranvier 7.531E-3 1.869E-2
8.950E-2
5.046E-1
 1 16
28 GO:0030673 axolemma 8.937E-3 1.996E-2
9.560E-2
5.988E-1
 1 19
29 GO:0097381 photoreceptor disc membrane 8.937E-3 1.996E-2
9.560E-2
5.988E-1
 1 19
30 GO:0099738 cell cortex region 8.937E-3 1.996E-2
9.560E-2
5.988E-1
 1 19
31 GO:0031253 cell projection membrane 1.004E-2 2.171E-2
1.040E-1
6.729E-1
 2 332
32 GO:0031430 M band 1.081E-2 2.263E-2
1.084E-1
7.243E-1
 1 23
33 GO:0045177 apical part of cell 1.631E-2 3.312E-2
1.586E-1
1.000E0
 2 428
34 GO:0098794 postsynapse 1.786E-2 3.520E-2
1.686E-1
1.000E0
 2 449
35 GO:0032391 photoreceptor connecting cilium 1.873E-2 3.586E-2
1.717E-1
1.000E0
 1 40
36 GO:0031672 A band 2.013E-2 3.727E-2
1.785E-1
1.000E0
 1 43
37 GO:0005912 adherens junction 2.058E-2 3.727E-2
1.785E-1
1.000E0
 2 484
38 GO:0001917 photoreceptor inner segment 2.152E-2 3.794E-2
1.817E-1
1.000E0
 1 46
39 GO:0032589 neuron projection membrane 2.290E-2 3.935E-2
1.885E-1
1.000E0
 1 49
40 GO:0016328 lateral plasma membrane 2.475E-2 4.146E-2
1.986E-1
1.000E0
 1 53
41 GO:0014704 intercalated disc 2.706E-2 4.422E-2
2.118E-1
1.000E0
 1 58
Show 36 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 102 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004835 Microspherocytosis 2.012E-8 1.642E-6 8.548E-6 2.053E-6 3 7
2 HP:0004839 Pyropoikilocytosis 3.219E-8 1.642E-6 8.548E-6 3.283E-6 3 8
3 HP:0004445 Elliptocytosis 1.641E-7 5.325E-6 2.773E-5 1.674E-5 3 13
4 HP:0004446 Stomatocytosis 2.088E-7 5.325E-6 2.773E-5 2.130E-5 3 14
5 HP:0008341 Distal renal tubular acidosis 3.897E-7 7.950E-6 4.140E-5 3.975E-5 3 17
6 HP:0004822 Atypical elliptocytosis 5.413E-6 9.202E-5 4.791E-4 5.521E-4 2 4
7 HP:0004444 Spherocytosis 1.045E-5 1.523E-4 7.930E-4 1.066E-3 3 49
8 HP:0001923 Reticulocytosis 3.954E-5 5.041E-4 2.625E-3 4.033E-3 3 76
9 HP:0004312 Abnormality of reticulocytes 9.297E-5 1.054E-3 5.486E-3 9.483E-3 3 101
10 HP:0005560 Imbalanced hemoglobin synthesis 1.407E-4 1.408E-3 7.333E-3 1.435E-2 3 116
11 HP:0001947 Renal tubular acidosis 1.519E-4 1.408E-3 7.333E-3 1.549E-2 3 119
12 HP:0011902 Abnormal hemoglobin 1.977E-4 1.681E-3 8.751E-3 2.017E-2 3 130
13 HP:0001889 Megaloblastic anemia 2.264E-4 1.776E-3 9.250E-3 2.309E-2 2 23
14 HP:0000124 Renal tubular dysfunction 2.572E-4 1.824E-3 9.497E-3 2.623E-2 3 142
15 HP:0001748 Polysplenia 2.682E-4 1.824E-3 9.497E-3 2.736E-2 2 25
16 HP:0004447 Poikilocytosis 5.283E-4 3.368E-3 1.754E-2
5.388E-2
 3 181
17 HP:0009799 Supernumerary spleens 7.282E-4 4.369E-3 2.275E-2
7.427E-2
 2 41
18 HP:0004804 Congenital hemolytic anemia 8.390E-4 4.711E-3 2.453E-2
8.558E-2
 2 44
19 HP:0004810 Congenital hypoplastic anemia 8.776E-4 4.711E-3 2.453E-2
8.952E-2
 2 45
20 HP:0004870 Chronic hemolytic anemia 9.987E-4 5.091E-3 2.651E-2
1.019E-1
 2 48
21 HP:0011895 Anemia due to reduced life span of red cells 1.098E-3 5.091E-3 2.651E-2
1.120E-1
 3 232
22 HP:0001878 Hemolytic anemia 1.098E-3 5.091E-3 2.651E-2
1.120E-1
 3 232
23 HP:0001978 Extramedullary hematopoiesis 1.773E-3 7.862E-3 4.094E-2
1.808E-1
 2 64
24 HP:0001972 Macrocytic anemia 2.559E-3 1.087E-2
5.662E-2
2.610E-1
 2 77
25 HP:0001908 Hypoplastic anemia 2.968E-3 1.211E-2
6.306E-2
3.027E-1
 2 83
26 HP:0008003 Jerky ocular pursuit movements 4.244E-3 1.561E-2
8.130E-2
4.328E-1
 1 4
27 HP:0025409 Abnormal spleen physiology 4.286E-3 1.561E-2
8.130E-2
4.372E-1
 2 100
28 HP:0001971 Hypersplenism 4.286E-3 1.561E-2
8.130E-2
4.372E-1
 2 100
29 HP:0001900 Increased hemoglobin 4.806E-3 1.690E-2
8.802E-2
4.902E-1
 2 106
30 HP:0001081 Cholelithiasis 5.449E-3 1.853E-2
9.646E-2
5.558E-1
 2 113
31 HP:0012437 Abnormal gallbladder morphology 6.535E-3 2.149E-2
1.119E-1
6.666E-1
 2 124
32 HP:0001890 Autoimmune hemolytic anemia 6.743E-3 2.149E-2
1.119E-1
6.878E-1
 2 126
33 HP:0001973 Autoimmune thrombocytopenia 8.166E-3 2.524E-2
1.314E-1
8.329E-1
 2 139
34 HP:0001941 Acidosis 8.742E-3 2.619E-2
1.364E-1
8.917E-1
 3 475
35 HP:0002904 Hyperbilirubinemia 8.985E-3 2.619E-2
1.364E-1
9.165E-1
 2 146
36 HP:0005264 Abnormality of the gallbladder 9.470E-3 2.683E-2
1.397E-1
9.659E-1
 2 150
37 HP:0000979 Purpura 1.099E-2 3.031E-2
1.578E-1
1.000E0
 2 162
38 HP:0000571 Hypometric saccades 1.164E-2 3.123E-2
1.626E-1
1.000E0
 1 11
39 HP:0007366 Atrophy/Degeneration affecting the brainstem 1.269E-2 3.318E-2
1.728E-1
1.000E0
 1 12
40 HP:0001901 Polycythemia 1.435E-2 3.660E-2
1.906E-1
1.000E0
 2 186
41 HP:0010972 Anemia of inadequate production 1.511E-2 3.758E-2
1.957E-1
1.000E0
 2 191
Show 36 more annotations

5: Mouse Phenotype [Display Chart] 8 input genes in category / 404 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002812 spherocytosis 2.651E-10 1.071E-7 7.047E-7 1.071E-7 4 16
2 MP:0008739 abnormal spleen iron level 4.562E-9 9.215E-7 6.064E-6 1.843E-6 4 31
3 MP:0010375 increased kidney iron level 1.371E-7 1.704E-5 1.121E-4 5.540E-5 3 15
4 MP:0008742 abnormal kidney iron level 1.687E-7 1.704E-5 1.121E-4 6.816E-5 3 16
5 MP:0002641 anisopoikilocytosis 3.430E-7 2.771E-5 1.823E-4 1.386E-4 3 20
6 MP:0002640 reticulocytosis 4.525E-7 3.047E-5 2.005E-4 1.828E-4 4 95
7 MP:0011913 abnormal reticulocyte cell number 8.168E-7 4.714E-5 3.102E-4 3.300E-4 4 110
8 MP:0002424 abnormal reticulocyte morphology 1.011E-6 5.106E-5 3.360E-4 4.085E-4 4 116
9 MP:0002591 decreased mean corpuscular volume 1.501E-6 6.737E-5 4.433E-4 6.063E-4 4 128
10 MP:0008807 increased liver iron level 1.791E-6 7.236E-5 4.761E-4 7.236E-4 3 34
11 MP:0001770 abnormal iron level 2.405E-6 8.832E-5 5.811E-4 9.715E-4 4 144
12 MP:0005637 abnormal iron homeostasis 2.831E-6 9.530E-5 6.271E-4 1.144E-3 4 150
13 MP:0008738 abnormal liver iron level 3.950E-6 1.227E-4 8.077E-4 1.596E-3 3 44
14 MP:0010733 abnormal axon initial segment morphology 7.823E-6 2.257E-4 1.485E-3 3.160E-3 2 6
15 MP:0000208 decreased hematocrit 9.075E-6 2.444E-4 1.608E-3 3.666E-3 4 201
16 MP:0008956 decreased cellular hemoglobin content 1.459E-5 3.684E-4 2.424E-3 5.895E-3 2 8
17 MP:0008954 abnormal cellular hemoglobin content 2.343E-5 5.568E-4 3.664E-3 9.466E-3 2 10
18 MP:0000226 abnormal mean corpuscular volume 2.707E-5 6.076E-4 3.998E-3 1.094E-2 4 265
19 MP:0002596 abnormal hematocrit 3.177E-5 6.756E-4 4.445E-3 1.284E-2 4 276
20 MP:0005563 abnormal hemoglobin content 3.756E-5 7.587E-4 4.992E-3 1.517E-2 4 288
21 MP:0005640 abnormal mean corpuscular hemoglobin concentration 4.313E-5 8.298E-4 5.460E-3 1.743E-2 3 97
22 MP:0013663 increased myeloid cell number 4.705E-5 8.640E-4 5.685E-3 1.901E-2 4 305
23 MP:0008808 decreased spleen iron level 7.062E-5 1.241E-3 8.162E-3 2.853E-2 2 17
24 MP:0008809 increased spleen iron level 7.942E-5 1.337E-3 8.797E-3 3.209E-2 2 18
25 MP:0001577 anemia 1.066E-4 1.723E-3 1.134E-2 4.309E-2 4 376
26 MP:0002813 microcytosis 1.429E-4 2.221E-3 1.461E-2
5.775E-2
 2 24
27 MP:0004952 increased spleen weight 2.060E-4 3.083E-3 2.029E-2
8.324E-2
 3 164
28 MP:0008415 abnormal neurite morphology 2.433E-4 3.510E-3 2.309E-2
9.827E-2
 4 465
29 MP:0003657 abnormal erythrocyte osmotic lysis 2.725E-4 3.796E-3 2.498E-2
1.101E-1
 2 33
30 MP:0001588 abnormal hemoglobin 2.862E-4 3.854E-3 2.536E-2
1.156E-1
 4 485
31 MP:0001585 hemolytic anemia 3.248E-4 4.100E-3 2.698E-2
1.312E-1
 2 36
32 MP:0010163 hemolysis 3.248E-4 4.100E-3 2.698E-2
1.312E-1
 2 36
33 MP:0005641 increased mean corpuscular hemoglobin concentration 3.621E-4 4.433E-3 2.917E-2
1.463E-1
 2 38
34 MP:0002874 decreased hemoglobin content 3.979E-4 4.634E-3 3.049E-2
1.608E-1
 3 205
35 MP:0002643 poikilocytosis 4.015E-4 4.634E-3 3.049E-2
1.622E-1
 2 40
36 MP:0005404 abnormal axon morphology 5.298E-4 5.945E-3 3.912E-2
2.140E-1
 3 226
37 MP:0004057 thin myocardium compact layer 6.281E-4 6.858E-3 4.512E-2
2.537E-1
 2 50
38 MP:0004951 abnormal spleen weight 7.370E-4 7.835E-3
5.156E-2
2.977E-1
 3 253
39 MP:0009547 elliptocytosis 7.726E-4 7.956E-3
5.235E-2
3.121E-1
 1 1
40 MP:0003656 abnormal erythrocyte physiology 7.877E-4 7.956E-3
5.235E-2
3.182E-1
 2 56
41 MP:0013328 visceromegaly 1.545E-3 1.486E-2
9.776E-2
6.240E-1
 1 2
42 MP:0010366 increased adrenal cortical tumor incidence 1.545E-3 1.486E-2
9.776E-2
6.240E-1
 1 2
43 MP:0004056 abnormal myocardium compact layer morphology 1.601E-3 1.505E-2
9.900E-2
6.470E-1
 2 80
44 MP:0005344 increased circulating bilirubin level 1.641E-3 1.507E-2
9.916E-2
6.631E-1
 2 81
45 MP:0009568 abnormal red blood cell deformability 2.316E-3 1.991E-2
1.310E-1
9.357E-1
 1 3
46 MP:0013309 adrenal gland cyst 2.316E-3 1.991E-2
1.310E-1
9.357E-1
 1 3
47 MP:0009906 increased tongue size 2.316E-3 1.991E-2
1.310E-1
9.357E-1
 1 3
48 MP:0005562 decreased mean corpuscular hemoglobin 2.588E-3 2.175E-2
1.431E-1
1.000E0
 2 102
49 MP:0001569 abnormal circulating bilirubin level 2.639E-3 2.175E-2
1.431E-1
1.000E0
 2 103
50 MP:0011391 abnormal fetal cardiomyocyte apoptosis 3.087E-3 2.398E-2
1.578E-1
1.000E0
 1 4
Show 45 more annotations

6: Domain [Display Chart] 9 input genes in category / 78 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00435 Spectrin Pfam 1.410E-16 1.100E-14 5.432E-14 1.100E-14 6 23
2 IPR002017 Spectrin repeat InterPro 6.628E-16 2.465E-14 1.218E-13 5.170E-14 6 29
3 IPR018159 Spectrin/alpha-actinin InterPro 1.264E-15 2.465E-14 1.218E-13 9.858E-14 6 32
4 SM00150 SPEC SMART 1.264E-15 2.465E-14 1.218E-13 9.858E-14 6 32
5 IPR001605 PH dom-spectrin-type InterPro 3.090E-12 4.821E-11 2.382E-10 2.411E-10 4 9
6 PS00020 ACTININ 2 PROSITE 2.165E-10 2.111E-9 1.043E-8 1.689E-8 4 23
7 PS00019 ACTININ 1 PROSITE 2.165E-10 2.111E-9 1.043E-8 1.689E-8 4 23
8 IPR001589 Actinin actin-bd CS InterPro 2.165E-10 2.111E-9 1.043E-8 1.689E-8 4 23
9 IPR016343 Spectrin bsu InterPro 3.065E-10 2.657E-9 1.313E-8 2.391E-8 3 4
10 SM00033 CH SMART 1.641E-8 1.280E-7 6.323E-7 1.280E-6 4 65
11 PF00307 CH Pfam 2.220E-8 1.529E-7 7.552E-7 1.731E-6 4 70
12 1.10.418.10 - Gene3D 2.352E-8 1.529E-7 7.552E-7 1.834E-6 4 71
13 PS50021 CH PROSITE 2.633E-8 1.580E-7 7.806E-7 2.054E-6 4 73
14 IPR001715 CH-domain InterPro 2.939E-8 1.638E-7 8.090E-7 2.293E-6 4 75
15 2.30.29.30 - Gene3D 4.539E-7 2.360E-6 1.166E-5 3.541E-5 5 391
16 IPR011993 PH dom-like InterPro 7.020E-7 3.422E-6 1.691E-5 5.476E-5 5 427
17 PF00169 PH Pfam 2.657E-6 1.219E-5 6.022E-5 2.072E-4 4 230
18 PF08726 EFhand Ca insen Pfam 3.074E-6 1.262E-5 6.235E-5 2.398E-4 2 6
19 IPR014837 EF-hand Ca insen InterPro 3.074E-6 1.262E-5 6.235E-5 2.398E-4 2 6
20 SM00233 PH SMART 5.719E-6 2.086E-5 1.030E-4 4.461E-4 4 279
21 PS50003 PH DOMAIN PROSITE 5.800E-6 2.086E-5 1.030E-4 4.524E-4 4 280
22 IPR001849 PH domain InterPro 5.883E-6 2.086E-5 1.030E-4 4.589E-4 4 281
23 IPR013315 Spectrin alpha SH3 InterPro 2.147E-5 7.281E-5 3.597E-4 1.675E-3 2 15
24 IPR027773 ADD2 InterPro 4.804E-4 1.561E-3 7.713E-3 3.747E-2 1 1
25 3.40.225.10 - Gene3D 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
26 IPR001303 Aldolase II/adducin N InterPro 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
27 IPR007477 SAB dom InterPro 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
28 SM01007 Aldolase II SMART 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
29 PF04382 SAB Pfam 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
30 IPR008379 Band 4.1 C InterPro 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
31 PF05902 4 1 CTD Pfam 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
32 PF00596 Aldolase II Pfam 1.920E-3 4.681E-3 2.312E-2
1.498E-1
 1 4
33 SM00054 EFh SMART 2.447E-3 5.784E-3 2.858E-2
1.909E-1
 2 158
34 PF00018 SH3 1 Pfam 2.633E-3 6.041E-3 2.985E-2
2.054E-1
 2 164
35 PF00868 Transglut N Pfam 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
36 PS00547 TRANSGLUTAMINASES PROSITE 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
37 PF00927 Transglut C Pfam 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
38 3.90.260.10 - Gene3D 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
39 IPR001102 Transglutaminase N InterPro 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
40 IPR013808 Transglutaminase AS InterPro 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
41 IPR023608 Gln gamma-glutamylTfrase euk InterPro 4.316E-3 8.211E-3 4.057E-2
3.367E-1
 1 9
42 SM00326 SH3 SMART 4.557E-3 8.226E-3 4.064E-2
3.554E-1
 2 217
43 PS50002 SH3 PROSITE 4.557E-3 8.226E-3 4.064E-2
3.554E-1
 2 217
44 IPR001452 SH3 domain InterPro 4.722E-3 8.226E-3 4.064E-2
3.683E-1
 2 221
45 IPR008958 Transglutaminase C InterPro 4.795E-3 8.226E-3 4.064E-2
3.740E-1
 1 10
46 PS50222 EF HAND 2 PROSITE 5.147E-3 8.226E-3 4.064E-2
4.015E-1
 2 231
47 IPR002048 EF hand dom InterPro 5.190E-3 8.226E-3 4.064E-2
4.049E-1
 2 232
48 SM00460 TGc SMART 5.273E-3 8.226E-3 4.064E-2
4.113E-1
 1 11
49 IPR002931 Transglutaminase-like InterPro 5.273E-3 8.226E-3 4.064E-2
4.113E-1
 1 11
50 PF01841 Transglut core Pfam 5.273E-3 8.226E-3 4.064E-2
4.113E-1
 1 11
Show 45 more annotations

7: Pathway [Display Chart] 8 input genes in category / 68 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270325 Interaction between L1 and Ankyrins BioSystems: REACTOME 3.208E-15 2.181E-13 1.048E-12 2.181E-13 6 30
2 1339109 COPI-mediated anterograde transport BioSystems: REACTOME 1.491E-12 5.071E-11 2.436E-10 1.014E-10 6 79
3 1270323 L1CAM interactions BioSystems: REACTOME 7.202E-12 1.632E-10 7.842E-10 4.897E-10 6 102
4 1268726 ER to Golgi Anterograde Transport BioSystems: REACTOME 3.822E-11 6.498E-10 3.122E-9 2.599E-9 6 134
5 1268725 Transport to the Golgi and subsequent modification BioSystems: REACTOME 1.355E-10 1.843E-9 8.856E-9 9.217E-9 6 165
6 1269440 SOS-mediated signalling BioSystems: REACTOME 1.593E-9 8.189E-9 3.934E-8 1.083E-7 6 248
7 1269383 SHC1 events in EGFR signaling BioSystems: REACTOME 1.593E-9 8.189E-9 3.934E-8 1.083E-7 6 248
8 1269382 GRB2 events in EGFR signaling BioSystems: REACTOME 1.593E-9 8.189E-9 3.934E-8 1.083E-7 6 248
9 1269285 RAF/MAP kinase cascade BioSystems: REACTOME 1.593E-9 8.189E-9 3.934E-8 1.083E-7 6 248
10 1269471 ARMS-mediated activation BioSystems: REACTOME 1.755E-9 8.189E-9 3.934E-8 1.193E-7 6 252
11 1269468 Signalling to p38 via RIT and RIN BioSystems: REACTOME 1.755E-9 8.189E-9 3.934E-8 1.193E-7 6 252
12 1269470 Frs2-mediated activation BioSystems: REACTOME 1.797E-9 8.189E-9 3.934E-8 1.222E-7 6 253
13 1269502 MAPK1/MAPK3 signaling BioSystems: REACTOME 1.840E-9 8.189E-9 3.934E-8 1.251E-7 6 254
14 1269469 Prolonged ERK activation events BioSystems: REACTOME 1.884E-9 8.189E-9 3.934E-8 1.281E-7 6 255
15 1269632 Signaling by Leptin BioSystems: REACTOME 1.929E-9 8.189E-9 3.934E-8 1.312E-7 6 256
16 1269322 Interleukin receptor SHC signaling BioSystems: REACTOME 2.022E-9 8.189E-9 3.934E-8 1.375E-7 6 258
17 1269465 Signalling to RAS BioSystems: REACTOME 2.069E-9 8.189E-9 3.934E-8 1.407E-7 6 259
18 1269485 VEGFR2 mediated cell proliferation BioSystems: REACTOME 2.168E-9 8.189E-9 3.934E-8 1.474E-7 6 261
19 1269321 Interleukin-2 signaling BioSystems: REACTOME 2.375E-9 8.262E-9 3.969E-8 1.615E-7 6 265
20 1269464 Signalling to ERKs BioSystems: REACTOME 2.430E-9 8.262E-9 3.969E-8 1.652E-7 6 266
21 1427866 RET signaling BioSystems: REACTOME 2.841E-9 8.587E-9 4.125E-8 1.932E-7 6 273
22 1269299 FCERI mediated MAPK activation BioSystems: REACTOME 2.904E-9 8.587E-9 4.125E-8 1.975E-7 6 274
23 1269323 Interleukin-3, 5 and GM-CSF signaling BioSystems: REACTOME 2.904E-9 8.587E-9 4.125E-8 1.975E-7 6 274
24 1270312 NCAM signaling for neurite out-growth BioSystems: REACTOME 3.238E-9 9.175E-9 4.408E-8 2.202E-7 6 279
25 1268714 Asparagine N-linked glycosylation BioSystems: REACTOME 3.680E-9 1.001E-8 4.809E-8 2.503E-7 6 285
26 1269501 MAPK family signaling cascades BioSystems: REACTOME 4.347E-9 1.137E-8 5.461E-8 2.956E-7 6 293
27 1269431 IRS-mediated signalling BioSystems: REACTOME 4.812E-9 1.167E-8 5.604E-8 3.272E-7 6 298
28 1269429 Insulin receptor signalling cascade BioSystems: REACTOME 5.110E-9 1.167E-8 5.604E-8 3.475E-7 6 301
29 1269618 IGF1R signaling cascade BioSystems: REACTOME 5.213E-9 1.167E-8 5.604E-8 3.545E-7 6 302
30 1269620 IRS-related events triggered by IGF1R BioSystems: REACTOME 5.213E-9 1.167E-8 5.604E-8 3.545E-7 6 302
31 1269617 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) BioSystems: REACTOME 5.318E-9 1.167E-8 5.604E-8 3.616E-7 6 303
32 1269428 Signaling by Insulin receptor BioSystems: REACTOME 8.251E-9 1.753E-8 8.423E-8 5.611E-7 6 326
33 1269483 VEGFA-VEGFR2 Pathway BioSystems: REACTOME 9.373E-9 1.931E-8 9.279E-8 6.374E-7 6 333
34 1269487 Signaling by SCF-KIT BioSystems: REACTOME 1.062E-8 2.100E-8 1.009E-7 7.221E-7 6 340
35 1269480 Signaling by VEGF BioSystems: REACTOME 1.081E-8 2.100E-8 1.009E-7 7.349E-7 6 341
36 1269479 Downstream signal transduction BioSystems: REACTOME 1.375E-8 2.598E-8 1.248E-7 9.353E-7 6 355
37 1269284 DAP12 signaling BioSystems: REACTOME 1.471E-8 2.703E-8 1.299E-7 1.000E-6 6 359
38 1269380 Signaling by EGFR BioSystems: REACTOME 1.679E-8 3.004E-8 1.443E-7 1.141E-6 6 367
39 1269283 DAP12 interactions BioSystems: REACTOME 1.880E-8 3.277E-8 1.575E-7 1.278E-6 6 374
40 1269478 Signaling by PDGF BioSystems: REACTOME 2.035E-8 3.460E-8 1.662E-7 1.384E-6 6 379
41 1269298 Fc epsilon receptor (FCERI) signaling BioSystems: REACTOME 2.100E-8 3.484E-8 1.674E-7 1.428E-6 6 381
42 1269460 NGF signalling via TRKA from the plasma membrane BioSystems: REACTOME 2.415E-8 3.911E-8 1.879E-7 1.642E-6 6 390
43 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 5.386E-8 8.518E-8 4.092E-7 3.663E-6 6 446
44 1269443 Signalling by NGF BioSystems: REACTOME 8.666E-8 1.339E-7 6.434E-7 5.893E-6 6 483
45 1270243 Nephrin interactions BioSystems: REACTOME 8.293E-5 1.253E-4 6.020E-4 5.639E-3 2 22
46 1270231 Cell-Cell communication BioSystems: REACTOME 3.086E-3 4.562E-3 2.191E-2
2.098E-1
 2 134
47 83060 Apoptosis BioSystems: KEGG 3.269E-3 4.730E-3 2.272E-2
2.223E-1
 2 138
48 1270289 Caspase-mediated cleavage of cytoskeletal proteins BioSystems: REACTOME 8.325E-3 1.179E-2
5.666E-2
5.661E-1
 1 13
49 M13143 uCalpain and friends in Cell spread MSigDB C2 BIOCARTA (v6.0) 1.151E-2 1.597E-2
7.674E-2
7.828E-1
 1 18
50 1269955 Miscellaneous transport and binding events BioSystems: REACTOME 1.215E-2 1.652E-2
7.936E-2
8.260E-1
 1 19
Show 45 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 880 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18796539 alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. Pubmed 1.800E-20 1.584E-17 1.166E-16 1.584E-17 6 12
2 12119179 Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. Pubmed 3.616E-19 1.591E-16 1.171E-15 3.182E-16 6 18
3 18723693 Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Pubmed 7.548E-19 2.214E-16 1.629E-15 6.643E-16 6 20
4 12049649 Mapping of a spectrin-binding domain of human erythrocyte membrane protein 4.2. Pubmed 1.421E-15 3.127E-13 2.301E-12 1.251E-12 4 4
5 20696915 Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor. Pubmed 3.782E-15 6.656E-13 4.897E-12 3.328E-12 5 21
6 8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Pubmed 9.870E-15 1.448E-12 1.065E-11 8.686E-12 5 25
7 22159418 Cell organization, growth, and neural and cardiac development require αII-spectrin. Pubmed 1.790E-13 2.250E-11 1.656E-10 1.575E-10 4 9
8 17607528 Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. Pubmed 4.687E-13 5.156E-11 3.794E-10 4.125E-10 4 11
9 23704327 The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Pubmed 6.875E-12 6.722E-10 4.946E-9 6.050E-9 4 20
10 15855279 Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. Pubmed 9.047E-12 7.962E-10 5.858E-9 7.962E-9 3 3
11 21412925 Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs. Pubmed 3.618E-11 2.274E-9 1.673E-8 3.184E-8 3 4
12 21566095 The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Pubmed 3.618E-11 2.274E-9 1.673E-8 3.184E-8 3 4
13 12820899 Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site. Pubmed 3.618E-11 2.274E-9 1.673E-8 3.184E-8 3 4
14 3862089 Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin. Pubmed 3.618E-11 2.274E-9 1.673E-8 3.184E-8 3 4
15 23728480 In vivo assembly of the axon initial segment in motor neurons. Pubmed 9.045E-11 4.975E-9 3.660E-8 7.960E-8 3 5
16 11274145 The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. Pubmed 9.045E-11 4.975E-9 3.660E-8 7.960E-8 3 5
17 16959763 Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Pubmed 2.027E-8 1.015E-6 7.466E-6 1.784E-5 4 138
18 30309841 NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy. Pubmed 2.075E-8 1.015E-6 7.466E-6 1.826E-5 3 25
19 16512683 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Pubmed 3.407E-8 1.578E-6 1.161E-5 2.998E-5 4 157
20 10852813 Spectrin tethers and mesh in the biosynthetic pathway. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
21 17905835 Conformational change of erythroid alpha-spectrin at the tetramerization site upon binding beta-spectrin. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
22 8776664 Spectrin-actin interaction is required for neurite extension in NB 2a/dl neuroblastoma cells. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
23 25830635 αII-spectrin regulates invadosome stability and extracellular matrix degradation. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
24 1742606 Identification of a mouse brain beta-spectrin cDNA and distribution of its mRNA in adult tissues. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
25 8406479 Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
26 16774987 Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
27 9675416 Characterization of a new beta-spectrin gene which is predominantly expressed in brain. Pubmed 4.936E-8 1.609E-6 1.184E-5 4.344E-5 2 2
28 16889989 alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Pubmed 5.394E-8 1.695E-6 1.247E-5 4.747E-5 3 34
29 20007969 Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
30 8479293 The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
31 20056793 Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
32 10874042 Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
33 12901833 Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
34 3693401 Erythrocyte adducin: a calmodulin-regulated actin-bundling protein that stimulates spectrin-actin binding. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
35 1467942 Developmental expression of brain beta-spectrin isoform messenger RNAs. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
36 20585040 The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
37 11069925 alpha -Catenin binds directly to spectrin and facilitates spectrin-membrane assembly in vivo. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
38 2971657 Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
39 11294830 A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
40 22197999 Enterohaemorrhagic Escherichia coli requires the spectrin cytoskeleton for efficient attachment and pedestal formation on host cells. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
41 10576550 Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells. Pubmed 1.481E-7 3.178E-6 2.338E-5 1.303E-4 2 3
42 27507650 Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Pubmed 1.901E-7 3.982E-6 2.930E-5 1.673E-4 4 241
43 25305142 β-Adducin siRNA disruption of the spectrin-based cytoskeleton in differentiating keratinocytes prevented by calcium acting through calmodulin/epidermal growth factor receptor/cadherin pathway. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
44 7642559 Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
45 29720258 T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
46 12044158 Functional characterization of spectrin-actin-binding domains in 4.1 family of proteins. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
47 1638088 Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome 11. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
48 24064296 Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
49 22632975 A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
50 12571280 Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links. Pubmed 2.961E-7 4.737E-6 3.486E-5 2.606E-4 2 4
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 383 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SPTAN1 SPTAN1 interactions 1.564E-12 5.989E-10 3.909E-9 5.989E-10 7 222
2 int:ANK1 ANK1 interactions 9.632E-10 1.845E-7 1.204E-6 3.689E-7 4 31
3 int:EPB41 EPB41 interactions 1.587E-8 2.026E-6 1.322E-5 6.077E-6 4 61
4 int:ADD1 ADD1 interactions 2.624E-8 2.512E-6 1.640E-5 1.005E-5 4 69
5 int:HOMER1 HOMER1 interactions 7.377E-8 4.715E-6 3.077E-5 2.825E-5 4 89
6 int:EPB42 EPB42 interactions 7.386E-8 4.715E-6 3.077E-5 2.829E-5 3 18
7 int:SPTBN4 SPTBN4 interactions 1.392E-7 7.619E-6 4.972E-5 5.333E-5 3 22
8 int:SPTB SPTB interactions 2.958E-7 1.416E-5 9.241E-5 1.133E-4 3 28
9 int:SHANK3 SHANK3 interactions 9.057E-7 3.854E-5 2.516E-4 3.469E-4 4 166
10 int:SPTBN2 SPTBN2 interactions 1.983E-6 7.215E-5 4.709E-4 7.595E-4 3 52
11 int:CNKSR2 CNKSR2 interactions 2.225E-6 7.215E-5 4.709E-4 8.520E-4 3 54
12 int:SPTBN5 SPTBN5 interactions 2.296E-6 7.215E-5 4.709E-4 8.793E-4 2 5
13 int:ACTA1 ACTA1 interactions 2.449E-6 7.215E-5 4.709E-4 9.379E-4 4 213
14 int:SPTA1 SPTA1 interactions 3.385E-6 9.261E-5 6.044E-4 1.296E-3 3 62
15 int:NCAPD3 NCAPD3 interactions 3.727E-6 9.517E-5 6.211E-4 1.428E-3 3 64
16 int:KALRN KALRN interactions 4.889E-6 1.170E-4 7.639E-4 1.873E-3 3 70
17 int:SLC9A2 SLC9A2 interactions 8.256E-6 1.860E-4 1.214E-3 3.162E-3 2 9
18 int:NCKAP1 NCKAP1 interactions 9.427E-6 2.006E-4 1.309E-3 3.610E-3 3 87
19 int:CYFIP2 CYFIP2 interactions 1.190E-5 2.399E-4 1.566E-3 4.558E-3 3 94
20 int:MYH9 MYH9 interactions 1.912E-5 3.662E-4 2.390E-3 7.324E-3 4 358
21 int:UBASH3B UBASH3B interactions 2.180E-5 3.976E-4 2.595E-3 8.350E-3 3 115
22 int:STYXL1 STYXL1 interactions 2.747E-5 4.782E-4 3.121E-3 1.052E-2 2 16
23 int:DISC1 DISC1 interactions 3.681E-5 6.130E-4 4.001E-3 1.410E-2 3 137
24 int:SLC4A1 SLC4A1 interactions 3.911E-5 6.242E-4 4.074E-3 1.498E-2 2 19
25 int:RABL2A RABL2A interactions 4.801E-5 7.355E-4 4.800E-3 1.839E-2 2 21
26 int:FANCF FANCF interactions 5.279E-5 7.777E-4 5.076E-3 2.022E-2 2 22
27 int:SYNPO SYNPO interactions 5.958E-5 8.451E-4 5.516E-3 2.282E-2 3 161
28 int:DLGAP1 DLGAP1 interactions 6.643E-5 9.087E-4 5.931E-3 2.544E-2 3 167
29 int:CELSR3 CELSR3 interactions 7.420E-5 9.439E-4 6.160E-3 2.842E-2 2 26
30 int:MYO18A MYO18A interactions 7.506E-5 9.439E-4 6.160E-3 2.875E-2 3 174
31 int:ANK2 ANK2 interactions 8.011E-5 9.439E-4 6.160E-3 3.068E-2 2 27
32 int:MYO19 MYO19 interactions 8.031E-5 9.439E-4 6.160E-3 3.076E-2 3 178
33 int:CYFIP1 CYFIP1 interactions 8.302E-5 9.439E-4 6.160E-3 3.180E-2 3 180
34 int:SPTBN1 SPTBN1 interactions 8.439E-5 9.439E-4 6.160E-3 3.232E-2 3 181
35 int:PDP1 PDP1 interactions 8.625E-5 9.439E-4 6.160E-3 3.304E-2 2 28
36 int:AGAP2 AGAP2 interactions 1.021E-4 1.086E-3 7.090E-3 3.911E-2 3 193
37 int:MYO1C MYO1C interactions 1.275E-4 1.208E-3 7.883E-3 4.882E-2 3 208
38 int:CALCOCO2 CALCOCO2 interactions 1.275E-4 1.208E-3 7.883E-3 4.882E-2 3 208
39 int:DDX19A DDX19A interactions 1.278E-4 1.208E-3 7.883E-3 4.895E-2 2 34
40 int:GAN GAN interactions 1.293E-4 1.208E-3 7.883E-3 4.952E-2 3 209
41 int:MYCBP2 MYCBP2 interactions 1.293E-4 1.208E-3 7.883E-3 4.952E-2 3 209
42 int:NENF NENF interactions 1.435E-4 1.278E-3 8.339E-3
5.494E-2
 2 36
43 int:PTP4A2 PTP4A2 interactions 1.435E-4 1.278E-3 8.339E-3
5.494E-2
 2 36
44 int:ERCC4 ERCC4 interactions 1.516E-4 1.320E-3 8.613E-3
5.807E-2
 2 37
45 int:CAVIN3 CAVIN3 interactions 1.774E-4 1.510E-3 9.855E-3
6.795E-2
 2 40
46 int:HCN1 HCN1 interactions 1.957E-4 1.630E-3 1.064E-2
7.497E-2
 2 42
47 int:EPOP EPOP interactions 2.052E-4 1.672E-3 1.092E-2
7.861E-2
 2 43
48 int:PEX5L PEX5L interactions 2.249E-4 1.758E-3 1.147E-2
8.613E-2
 2 45
49 int:GRIA2 GRIA2 interactions 2.249E-4 1.758E-3 1.147E-2
8.613E-2
 2 45
50 int:DCTN1 DCTN1 interactions 2.464E-4 1.887E-3 1.232E-2
9.437E-2
 3 260
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q15-q21 15q15-q21 1.038E-3 8.559E-3 2.421E-2 9.344E-3 1 4
2 1p33-p32 1p33-p32 2.594E-3 8.559E-3 2.421E-2 2.334E-2 1 10
3 15q21 15q21 2.853E-3 8.559E-3 2.421E-2 2.568E-2 1 11
4 19q13.13 19q13.13 3.889E-3 8.749E-3 2.475E-2 3.500E-2 1 15
5 2p13.3 2p13.3 9.568E-3 1.722E-2 4.872E-2
8.611E-2
 1 37
6 9q34.11 9q34.11 1.522E-2 2.154E-2
6.094E-2
1.370E-1
 1 59
7 2p21 2p21 1.675E-2 2.154E-2
6.094E-2
1.508E-1
 1 65
8 1q21 1q21 2.389E-2 2.688E-2
7.604E-2
2.150E-1
 1 93
9 11q13 11q13 3.048E-2 3.048E-2
8.623E-2
2.743E-1
 1 119
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 87 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1113 Pleckstrin homology domain containing|Spectrins genenames.org 3.893E-21 2.336E-20 5.723E-20 2.336E-20 6 7
2 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 7.682E-5 2.305E-4 5.647E-4 4.609E-4 3 206
3 951 Erythrocyte membrane protein band 4.1|FERM domain containing genenames.org 1.758E-3 3.516E-3 8.613E-3 1.055E-2 1 4
4 863 EF-hand domain containing genenames.org 3.850E-3 4.742E-3 1.162E-2 2.310E-2 2 219
5 773 Transglutaminases genenames.org 3.951E-3 4.742E-3 1.162E-2 2.371E-2 1 9
6 1293 Minor histocompatibility antigens|FERM domain containing genenames.org 2.178E-2 2.178E-2
5.336E-2
1.307E-1
 1 50
Show 1 more annotation

13: Coexpression [Display Chart] 9 input genes in category / 736 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2442 Major erythrocyte membrane genes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.438E-11 1.058E-8 7.598E-8 1.058E-8 4 15
2 M5945 Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation. MSigDB H: Hallmark Gene Sets (v6.0) 6.599E-7 2.429E-4 1.744E-3 4.857E-4 4 200
3 19658189-TableS8c Human EmbryonicStemCell Xu09 63genes GeneSigDB 1.448E-6 3.553E-4 2.551E-3 1.066E-3 3 61
4 20032505-TableS3 Human Leukemia Stam09 97genes GeneSigDB 3.817E-6 6.033E-4 4.331E-3 2.809E-3 3 84
5 11731795-SuppTable1 Human Lymphoma Armstrong02 100genes UnderExpressed GeneSigDB 4.098E-6 6.033E-4 4.331E-3 3.016E-3 3 86
6 M2544 Genes up-regulated in liver samples containing tumor thrombi in the major branches of the portal vein at surgery (PT) compared to those from metastasis-free HCC patients (PN) at the time of surgery and at follow-up. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.695E-6 9.440E-4 6.777E-3 5.664E-3 3 106
7 17312329-SuppTable2 Human Leukemia Juric07 617genes GeneSigDB 1.632E-5 1.716E-3 1.232E-2 1.201E-2 4 449
8 M5893 Genes important for mitotic spindle assembly. MSigDB H: Hallmark Gene Sets (v6.0) 5.144E-5 4.282E-3 3.074E-2 3.786E-2 3 200
9 15358818-table1 Human Stomach Yuan04 32genes GeneSigDB 5.818E-5 4.282E-3 3.074E-2 4.282E-2 2 30
10 18487511-TableS2 Human StemCell Singleton08 47genes GeneSigDB 5.818E-5 4.282E-3 3.074E-2 4.282E-2 2 30
11 15955831-Table4 Human StemCell Komor05 39genes GeneSigDB 9.893E-5 6.619E-3 4.752E-2
7.281E-2
 2 39
12 M1551 Genes whose splicing in neocortex was most affected by knock out of NOVA2 [GeneID=4858]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.205E-4 7.388E-3
5.304E-2
8.866E-2
 2 43
13 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.096E-4 2.885E-2
2.071E-1
3.751E-1
 3 435
14 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 6.915E-4 3.571E-2
2.564E-1
5.089E-1
 3 483
15 20032505-TableS6 Human Leukemia Stam09 150genes Figure4 GeneSigDB 7.890E-4 3.571E-2
2.564E-1
5.807E-1
 2 110
16 M10381 Genes down-regulated in transformed NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845]) vs normal cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.309E-3 3.571E-2
2.564E-1
9.634E-1
 2 142
17 M2898 Genes down-regulated in epithelial breast cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845 gene]. MSigDB C6: Oncogenic Signatures (v6.0) 1.327E-3 3.571E-2
2.564E-1
9.769E-1
 2 143
18 M2893 Genes down-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.346E-3 3.571E-2
2.564E-1
9.905E-1
 2 144
19 M15047 The 'NPM1 signature 3': genes down-regulated in pediatric AML (acute myeloid leukemia) with mutated NPM1 [GeneID=4869] compared to the AML cases with intact NPM1 and MLL [GeneID=4297]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.698E-3 3.571E-2
2.564E-1
1.000E0
 2 162
20 M1754 Genes with promoters bound by FOXP3 [GeneID=50943] and which are down-regulated both in developing (located in the thymus) and mature (from peripheral blood) regulatory CD4+ [GeneID=920] T lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.944E-3 3.571E-2
2.564E-1
1.000E0
 1 5
21 M2115 Genes correlated with proneural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.022E-3 3.571E-2
2.564E-1
1.000E0
 2 177
22 M2812 Genes down-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 2.253E-3 3.571E-2
2.564E-1
1.000E0
 2 187
23 M6169 Genes down-regulated in D10.G4.1 T cell line (12h): control versus treated with NMU [GeneID=10874]. MSigDB C7: Immunologic Signatures (v6.0) 2.349E-3 3.571E-2
2.564E-1
1.000E0
 2 191
24 M6512 Genes up-regulated in epithelial cells (6h): untreated versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.447E-3 3.571E-2
2.564E-1
1.000E0
 2 195
25 M4961 Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 2.447E-3 3.571E-2
2.564E-1
1.000E0
 2 195
26 M8611 Genes down-regulated in bone marrow-derived dendritic cells CSF2 [GeneID=1437] versus CSF2 [GeneID=1437] and low dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v6.0) 2.447E-3 3.571E-2
2.564E-1
1.000E0
 2 195
27 M4943 Genes up-regulated in comparison of B cells versus myeloid dendritic cells (mDC). MSigDB C7: Immunologic Signatures (v6.0) 2.447E-3 3.571E-2
2.564E-1
1.000E0
 2 195
28 M4936 Genes up-regulated in comparison of B cells versus monocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 3.571E-2
2.564E-1
1.000E0
 2 196
29 M5141 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from infancts with acute RSV infection versus PBMCs from infants with acute influenza infection. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 3.571E-2
2.564E-1
1.000E0
 2 196
30 M7287 Genes down-regulated in monocytes: control versus HCMV infection. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 3.571E-2
2.564E-1
1.000E0
 2 197
31 M6279 Genes up-regulated in thymic macrophages versus medullary thymic epithelial cells (mTEC). MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.571E-2
2.564E-1
1.000E0
 2 198
32 M7701 Genes down-regulated in CD4 [GeneID=920] T cells: control versus tretinoin [PubChem=444795]. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.571E-2
2.564E-1
1.000E0
 2 198
33 M3136 Genes up-regulated in comparison of macrophages cultured with M-CSF [GeneID=1435] versus macrophages cultured with M-CSF [GeneID=1435] and Pam3Cyc. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.571E-2
2.564E-1
1.000E0
 2 199
34 M5732 Genes down-regulated in comparison of thymus regulatory T cells versus thymus conventional T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
35 M5480 Genes down-regulated in comparison of dendritic cells (DC) versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
36 M7607 Genes down-regulated in CD11b+ cells from BALB/c mice bearing: C26GM colon carcinoma versus 4T1 mammary carcinoma. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
37 M7525 Genes up-regulated in double positive thymocytes stimulated by anti-CD3: ELK4 [GeneID=2005] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
38 M7516 Genes up-regulated in CD4 [GeneID=920] follicular helper T cells (Tfh) with SH2D1A [GeneID=4068] knockout versus non-Tfh cells with SH2D1A [GeneID=4068] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
39 M7496 Genes down-regulated in SELL dim [GeneID=6402] NK cells: NCAM1+ [GeneID=4684] versus NCAM1- [GeneID=4684]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
40 M4996 Genes up-regulated in comparison of monocytes from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
41 M7492 Genes down-regulated in NCAM+ [GeneID=4684] NK cells: SELL bright [GeneID=6402] versus SELL dim [GeneID=6402]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
42 M5675 Genes up-regulated in comparison of TconvThy versus TregThy (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
43 M5185 Genes up-regulated in comparison of dendritic cells (DC) exposed to 50 worm/well B. malayi versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
44 M5486 Genes down-regulated in comparison of dendritic cells (DC) versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
45 M3121 Genes down-regulated in comparison of peripheral mononuclear blood cells (PBMC) versus memory T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
46 M5063 Genes down-regulated in comparison of CD4- [GeneID=920] CD8- thymocytes versus CD4- [GeneID=920] CD8+ thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
47 M3897 Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
48 M9062 Genes down-regulated in monocytes treated by rosiglitazone [PubChem=77999]: Ly6C high versus Ly6C low. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
49 M7489 Genes up-regulated in NCAM+ [GeneID=4684] NK cells: SELL bright [GeneID=6402] versus SELL dim [GeneID=6402]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
50 M7495 Genes down-regulated in NCAM1+ SELL bright [GeneID=4684;6402] versus NCAM1- SELL dim [GeneID=4684;6402]. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.571E-2
2.564E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 595 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Kidney10XCellRanger Six2KI E14 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2KI E14 Eryth Eryth Overall Top 200 Genes 1.880E-7 5.322E-5 3.708E-4 1.119E-4 4 138
2 Kidney10XCellRanger Six2TGC E14 Eryth Eryth Top 200 Kidney10XCellRanger Six2TGC E14 Eryth Eryth Top 200 2.920E-7 5.322E-5 3.708E-4 1.738E-4 4 154
3 Kidney10XCellRanger Six2TGC E14 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2TGC E14 Eryth Eryth Overall Top 200 Genes 2.920E-7 5.322E-5 3.708E-4 1.738E-4 4 154
4 Kidney10XCellRanger Six2KI E14 Eryth Eryth Subtype E14-Six2KI-Eryth-C11-KC7 Top 200 Genes Kidney10XCellRanger Six2KI E14 Eryth Eryth Subtype E14-Six2KI-Eryth-C11-KC7 Top 200 Genes 3.578E-7 5.322E-5 3.708E-4 2.129E-4 4 162
5 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C7-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C7-KC1 Top 200 Genes 4.655E-7 5.539E-5 3.859E-4 2.770E-4 4 173
6 Kidney10XCellRanger Six2KI E14 Eryth Eryth Subtype E14-Six2KI-Eryth-C12-KC7 Top 200 Genes Kidney10XCellRanger Six2KI E14 Eryth Eryth Subtype E14-Six2KI-Eryth-C12-KC7 Top 200 Genes 1.010E-6 8.749E-5 6.095E-4 6.009E-4 4 210
7 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C6-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C6-KC1 Top 200 Genes 1.029E-6 8.749E-5 6.095E-4 6.124E-4 4 211
8 Kidney10XCellRanger Six2KI E14 Eryth Eryth Top 200 Kidney10XCellRanger Six2KI E14 Eryth Eryth Top 200 1.427E-6 1.061E-4 7.392E-4 8.488E-4 4 229
9 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Top 200 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Top 200 4.456E-6 2.946E-4 2.052E-3 2.651E-3 4 305
10 PP RBC 1000 K4 PP RBC top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.652E-5 9.830E-4 6.848E-3 9.830E-3 4 425
11 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Overall Top 200 Genes 2.154E-5 1.037E-3 7.224E-3 1.282E-2 3 141
12 Kidney10XCellRanger Six2TGC P0 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2TGC P0 Eryth Eryth Overall Top 200 Genes 2.294E-5 1.037E-3 7.224E-3 1.365E-2 3 144
13 Kidney10XCellRanger Six2TGC P0 Eryth Eryth Top 200 Kidney10XCellRanger Six2TGC P0 Eryth Eryth Top 200 2.294E-5 1.037E-3 7.224E-3 1.365E-2 3 144
14 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Erythrocyte (ER) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Erythrocyte (ER) Fetal, Development 2.440E-5 1.037E-3 7.224E-3 1.452E-2 3 147
15 Kidney10XCellRanger Six2TGC TSC1 P0 Eryth Eryth Top 200 Kidney10XCellRanger Six2TGC TSC1 P0 Eryth Eryth Top 200 3.027E-5 1.058E-3 7.373E-3 1.801E-2 3 158
16 Kidney10XCellRanger Six2TGC TSC1 P0 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Eryth Eryth Overall Top 200 Genes 3.027E-5 1.058E-3 7.373E-3 1.801E-2 3 158
17 PP MEP 2500 K2 PP MEP top-relative-expression-ranked 2500 k-means-cluster#2 PCBC 3.055E-5 1.058E-3 7.373E-3 1.818E-2 4 497
18 PP MEP 1000 K1 PP MEP top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 3.202E-5 1.058E-3 7.373E-3 1.905E-2 3 161
19 Kidney10XCellRanger Six2KI P0 Eryth Eryth Top 200 Kidney10XCellRanger Six2KI P0 Eryth Eryth Top 200 3.833E-5 1.140E-3 7.943E-3 2.280E-2 3 171
20 Kidney10XCellRanger Six2KI P0 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2KI P0 Eryth Eryth Overall Top 200 Genes 3.833E-5 1.140E-3 7.943E-3 2.280E-2 3 171
21 Erythrocyte (ER) Erythrocyte (ER) 5.412E-5 1.533E-3 1.068E-2 3.220E-2 3 192
22 PP RBC 500 K2 PP RBC top-relative-expression-ranked 500 k-means-cluster#2 PCBC 7.681E-5 2.077E-3 1.447E-2 4.570E-2 3 216
23 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C1-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C1-KC1 Top 200 Genes 8.111E-5 2.098E-3 1.462E-2 4.826E-2 3 220
24 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Erythroblast Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Erythroblast Top 200 Genes 1.656E-4 4.106E-3 2.861E-2
9.855E-2
 3 280
25 bone marrow bone marrow Human Protein Atlas 1.894E-4 4.507E-3 3.140E-2
1.127E-1
 3 293
26 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes 2.050E-4 4.692E-3 3.269E-2
1.220E-1
 3 301
27 10X Human 8K PBMC CD4 T cells Subtype CD4 T cells-ITGB1, ANXA1, KLRB1 Top 200 Genes 10X Human 8K PBMC CD4 T cells Subtype CD4 T cells-ITGB1, ANXA1, KLRB1 Top 200 Genes 3.442E-4 7.586E-3
5.285E-2
2.048E-1
 3 359
28 10X Human 8K PBMC T cell Subtype T cell-IL32, B2M, ITGB1 Top 200 Genes 10X Human 8K PBMC T cell Subtype T cell-IL32, B2M, ITGB1 Top 200 Genes 4.193E-4 8.911E-3
6.208E-2
2.495E-1
 3 384
29 BM Top 100 - bone marrow BM Top 100 - bone marrow Body Map 4.351E-4 8.927E-3
6.219E-2
2.589E-1
 2 77
30 PP MEP 500 K1 PP MEP top-relative-expression-ranked 500 k-means-cluster#1 PCBC 5.300E-4 1.051E-2
7.323E-2
3.153E-1
 2 85
31 PP RBC 100 PP RBC top-relative-expression-ranked 100 PCBC 7.325E-4 1.406E-2
9.794E-2
4.358E-1
 2 100
32 PP epoMEP 1000 K2 PP epoMEP top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 8.693E-4 1.585E-2
1.104E-1
5.172E-1
 2 109
33 PP RBC 500 PP RBC top-relative-expression-ranked 500 PCBC 8.792E-4 1.585E-2
1.104E-1
5.232E-1
 3 495
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F7 Adult, Development, and Cancer types 1.509E-3 2.641E-2
1.840E-1
8.980E-1
 2 144
35 PP MEG 2500 K1 PP MEG top-relative-expression-ranked 2500 k-means-cluster#1 PCBC 2.292E-3 3.597E-2
2.506E-1
1.000E0
 2 178
36 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Overall Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Overall Top 200 Genes 2.343E-3 3.597E-2
2.506E-1
1.000E0
 2 180
37 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Overall Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Overall Top 200 Genes 2.395E-3 3.597E-2
2.506E-1
1.000E0
 2 182
38 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Overall Top 200 Genes 2.499E-3 3.597E-2
2.506E-1
1.000E0
 2 186
39 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Overall Top 200 Genes BrainMap 2.499E-3 3.597E-2
2.506E-1
1.000E0
 2 186
40 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron BrainMap 2.499E-3 3.597E-2
2.506E-1
1.000E0
 2 186
41 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Cfh BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Cfh BrainMap 2.606E-3 3.597E-2
2.506E-1
1.000E0
 2 190
42 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/FrontalCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/FrontalCortex BrainMap 2.606E-3 3.597E-2
2.506E-1
1.000E0
 2 190
43 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/Rorb/subGroup2//Gja1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/Rorb/subGroup2//Gja1 BrainMap 2.633E-3 3.597E-2
2.506E-1
1.000E0
 2 191
44 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B Top 200 Genes 2.660E-3 3.597E-2
2.506E-1
1.000E0
 2 192
45 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C Top 200 Genes 2.939E-3 3.691E-2
2.572E-1
1.000E0
 2 202
46 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes 3.054E-3 3.691E-2
2.572E-1
1.000E0
 2 206
47 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND07-28 Top 200 Genes 3.142E-3 3.691E-2
2.572E-1
1.000E0
 2 209
48 Facebase RNAseq e9.5 Olfactory Placode 1000 K2 FacebaseRNAseq e9.5 Olfactory Placode top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 3.172E-3 3.691E-2
2.572E-1
1.000E0
 2 210
49 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B E18.5 Top 200 Genes 3.172E-3 3.691E-2
2.572E-1
1.000E0
 2 210
50 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C PND07-28 Top 200 Genes 3.201E-3 3.691E-2
2.572E-1
1.000E0
 2 211
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19762 GNF2 TAL1 Neighborhood of TAL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.014E-5 5.035E-4 1.921E-3 5.035E-4 3 73
2 M14260 MODULE 524 Actin cytoskeleton binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.391E-4 2.160E-3 8.241E-3 5.979E-3 2 30
3 M2119 MODULE 419 Genes in the cancer module 419. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.079E-4 2.160E-3 8.241E-3 7.698E-3 2 34
4 M14349 GNF2 PCAF Neighborhood of PCAF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.455E-4 2.160E-3 8.241E-3 8.638E-3 2 36
5 M7470 GNF2 CDC27 Neighborhood of CDC27 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.615E-4 3.746E-3 1.429E-2 2.404E-2 2 60
6 M9058 GNF2 BNIP3L Neighborhood of BNIP3L MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.234E-3 3.746E-3 1.429E-2 3.084E-2 2 68
7 M19158 GNF2 RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.270E-3 3.746E-3 1.429E-2 3.175E-2 2 69
8 M11900 GNF2 ANK1 Neighborhood of ANK1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.459E-3 3.746E-3 1.429E-2 3.648E-2 2 74
9 M5633 GNF2 SPTB Neighborhood of SPTB MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.459E-3 3.746E-3 1.429E-2 3.648E-2 2 74
10 M1670 GNF2 MAP2K3 Neighborhood of MAP2K3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.498E-3 3.746E-3 1.429E-2 3.746E-2 2 75
11 M13711 GNF2 SPTA1 Neighborhood of SPTA1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.745E-3 3.967E-3 1.514E-2 4.363E-2 2 81
12 M7663 MODULE 67 Genes in the cancer module 67. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.303E-2 2.715E-2
1.036E-1
3.258E-1
 2 227
13 M7693 MODULE 500 Genes in the cancer module 500. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.367E-2 4.366E-2
1.666E-1
5.918E-1
 1 30
14 M10458 GNF2 PRDX2 Neighborhood of PRDX2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.445E-2 4.366E-2
1.666E-1
6.113E-1
 1 31
Show 9 more annotations

16: MicroRNA [Display Chart] 9 input genes in category / 338 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-361-3p:mirSVR highEffct hsa-miR-361-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.956E-6 3.027E-3 1.938E-2 3.027E-3 3 346
2 hsa-miR-3685:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.061E-5 1.193E-2
7.639E-2
 2.387E-2 2 102
3 hsa-miR-1301-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.684E-4 3.024E-2
1.936E-1
9.071E-2
 2 199
4 hsa-miR-1225-3p:mirSVR highEffct hsa-miR-1225-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.521E-4 3.505E-2
2.244E-1
1.866E-1
 2 286
5 CGGTGTG,MIR-220:MSigDB CGGTGTG,MIR-220:MSigDB MSigDB 7.473E-4 3.505E-2
2.244E-1
2.526E-1
 1 6
6 hsa-miR-125b-1*:mirSVR lowEffct hsa-miR-125b-1*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.544E-4 3.505E-2
2.244E-1
3.226E-1
 2 377
7 hsa-miR-922:PITA hsa-miR-922:PITA TOP PITA 1.000E-3 3.505E-2
2.244E-1
3.380E-1
 2 386
8 hsa-miR-1225-5p:mirSVR highEffct hsa-miR-1225-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.026E-3 3.505E-2
2.244E-1
3.467E-1
 2 391
9 hsa-miR-331-3p:Functional MTI Functional MTI miRTarbase 1.105E-3 3.505E-2
2.244E-1
3.735E-1
 2 406
10 hsa-miR-874:mirSVR highEffct hsa-miR-874:mirSVR conserved highEffect-0.5 MicroRNA.org 1.165E-3 3.505E-2
2.244E-1
3.938E-1
 2 417
11 hsa-miR-760:TargetScan hsa-miR-760 TargetScan 1.204E-3 3.505E-2
2.244E-1
4.069E-1
 2 424
12 hsa-miR-135a:PITA hsa-miR-135a:PITA TOP PITA 1.348E-3 3.505E-2
2.244E-1
4.557E-1
 2 449
13 hsa-miR-135b:PITA hsa-miR-135b:PITA TOP PITA 1.348E-3 3.505E-2
2.244E-1
4.557E-1
 2 449
Show 8 more annotations

17: Drug [Display Chart] 9 input genes in category / 3153 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000197570 ADPribulose Stitch 7.308E-19 2.304E-15 1.989E-14 2.304E-15 6 13
2 CID000028127 PRODAN Stitch 2.131E-18 3.359E-15 2.900E-14 6.719E-15 6 15
3 CID000092266 2-nitro-5-thiocyanobenzoic acid Stitch 4.110E-18 4.319E-15 3.729E-14 1.296E-14 7 48
4 CID000025738 dimethyl adipimidate Stitch 2.524E-16 1.989E-13 1.718E-12 7.958E-13 6 30
5 CID000000979 p-hydroxyphenylpyruvate Stitch 4.503E-16 2.840E-13 2.451E-12 1.420E-12 7 91
6 CID000026259 tetrathionate Stitch 5.931E-15 2.788E-12 2.407E-11 1.870E-11 6 49
7 CID000010935 maleimide Stitch 6.190E-15 2.788E-12 2.407E-11 1.952E-11 7 131
8 CID000000061 2,3-DPG Stitch 8.526E-15 3.360E-12 2.901E-11 2.688E-11 7 137
9 CID000026197 dimyristoylphosphatidylcholine Stitch 3.175E-14 1.112E-11 9.602E-11 1.001E-10 6 64
10 CID000004278 1,1'-azobis(N,N-dimethylformamide Stitch 4.499E-14 1.418E-11 1.225E-10 1.418E-10 7 173
11 CID000018752 plakin Stitch 1.480E-13 3.888E-11 3.356E-10 4.665E-10 6 82
12 CID000007516 phenylhydrazine Stitch 1.480E-13 3.888E-11 3.356E-10 4.665E-10 6 82
13 CID000001951 AC1L1CLB Stitch 3.010E-13 7.300E-11 6.302E-10 9.490E-10 6 92
14 CID000003910 Leupeptin hydrochloride Stitch 1.230E-12 2.769E-10 2.391E-9 3.877E-9 7 276
15 CID000446872 AC1L9K72 Stitch 1.830E-12 3.846E-10 3.320E-9 5.769E-9 7 292
16 CID000004752 NSC 523214 Stitch 5.301E-12 1.045E-9 9.019E-9 1.672E-8 6 147
17 CID000445141 AC1L9HHR Stitch 7.099E-12 1.317E-9 1.137E-8 2.238E-8 7 354
18 CID000072430 MDL 28170 Stitch 7.640E-12 1.338E-9 1.155E-8 2.409E-8 5 54
19 CID000448772 32 P Stitch 1.828E-11 3.033E-9 2.618E-8 5.763E-8 7 405
20 CID000107729 6-propionyl-2-(dimethylamino)naphthalene Stitch 2.018E-11 3.182E-9 2.747E-8 6.364E-8 4 16
21 CID000004072 AC1L1HCM Stitch 8.104E-11 1.217E-8 1.050E-7 2.555E-7 4 22
22 CID000065167 POPC Stitch 4.471E-10 6.408E-8 5.532E-7 1.410E-6 6 306
23 CID000005566 trifluoperazine Stitch 6.423E-10 8.805E-8 7.602E-7 2.025E-6 6 325
24 CID000019731 Coomassie blue Stitch 8.277E-10 1.087E-7 9.388E-7 2.610E-6 5 135
25 CID000024584 MgCl2 Stitch 1.073E-9 1.353E-7 1.169E-6 3.384E-6 6 354
26 CID000001103 spermine Stitch 2.040E-9 2.473E-7 2.135E-6 6.431E-6 6 394
27 CID000019001 dithiotreitol Stitch 3.443E-9 4.021E-7 3.472E-6 1.086E-5 6 430
28 CID000002532 AC1L1DW2 Stitch 4.164E-9 4.689E-7 4.048E-6 1.313E-5 5 186
29 CID000066161 MAPS Stitch 4.758E-9 5.173E-7 4.466E-6 1.500E-5 5 191
30 CID000030956 AC1L1KMJ Stitch 6.324E-9 6.647E-7 5.738E-6 1.994E-5 6 476
31 CID005310949 HT-AMP Stitch 8.277E-7 8.419E-5 7.268E-4 2.610E-3 2 4
32 CID005311291 MeTRH Stitch 1.651E-5 1.627E-3 1.405E-2
5.207E-2
 2 16
33 CID000444690 Ge 3 Stitch 2.887E-5 2.758E-3 2.381E-2
9.103E-2
 2 21
34 CID000067050 rhodizonic acid Stitch 3.292E-5 3.053E-3 2.636E-2
1.038E-1
 3 170
35 5733 UP Syrosingopine [84-36-6]; Up 200; 6uM; PC3; HT HG-U133A Broad Institute CMAP Up 4.445E-5 3.240E-3 2.797E-2
1.401E-1
 3 188
36 6949 UP troglitazone; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.806E-5 3.240E-3 2.797E-2
1.515E-1
 3 193
37 2517 UP Cephalothin sodium salt [58-71-9]; Up 200; 9.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.956E-5 3.240E-3 2.797E-2
1.563E-1
 3 195
38 6303 UP Amphotericin B [1397-89-3]; Up 200; 4.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.032E-5 3.240E-3 2.797E-2
1.587E-1
 3 196
39 2295 UP Riluzole hydrochloride; Up 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.032E-5 3.240E-3 2.797E-2
1.587E-1
 3 196
40 6026 DN Deltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.109E-5 3.240E-3 2.797E-2
1.611E-1
 3 197
41 314 UP sulindac sulfone; Up 200; 50uM; MCF7; HG-U133A Broad Institute CMAP Up 5.109E-5 3.240E-3 2.797E-2
1.611E-1
 3 197
42 3385 UP Nizatidine [76963-41-2]; Up 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.109E-5 3.240E-3 2.797E-2
1.611E-1
 3 197
43 3024 UP Doxazosin mesylate [77883-43-3]; Up 200; 7.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.186E-5 3.240E-3 2.797E-2
1.635E-1
 3 198
44 3548 UP Natamycin [7681-93-8]; Up 200; 6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.186E-5 3.240E-3 2.797E-2
1.635E-1
 3 198
45 3381 UP Niacin [59-67-6]; Up 200; 32.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.186E-5 3.240E-3 2.797E-2
1.635E-1
 3 198
46 6865 DN SC-560; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.186E-5 3.240E-3 2.797E-2
1.635E-1
 3 198
47 CID016019984 L-E-D Stitch 5.189E-5 3.240E-3 2.797E-2
1.636E-1
 2 28
48 5766 UP Skimmianine [83-95-4]; Up 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.265E-5 3.240E-3 2.797E-2
1.660E-1
 3 199
49 3361 DN Iocetamic acid [16034-77-8]; Down 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.265E-5 3.240E-3 2.797E-2
1.660E-1
 3 199
50 3932 UP Furaltadone hydrochloride [3759-92-0]; Up 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.265E-5 3.240E-3 2.797E-2
1.660E-1
 3 199
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 128 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0013902 Elliptocytosis, Hereditary DisGeNET Curated 6.422E-8 8.220E-6 4.466E-5 8.220E-6 3 18
2 C0002878 Anemia, Hemolytic DisGeNET Curated 1.591E-7 1.018E-5 5.533E-5 2.037E-5 4 114
3 C0553720 Spherocytosis DisGeNET Curated 2.131E-6 6.819E-5 3.705E-4 2.728E-4 2 5
4 C0221409 Anemia, hereditary spherocytic hemolytic DisGeNET Curated 2.131E-6 6.819E-5 3.705E-4 2.728E-4 2 5
5 C0427480 Elliptocytosis found DisGeNET Curated 4.473E-6 1.145E-4 6.221E-4 5.725E-4 2 7
6 C0037889 Hereditary spherocytosis DisGeNET Curated 9.846E-5 2.100E-3 1.141E-2 1.260E-2 2 31
7 C0037769 West Syndrome DisGeNET Curated 3.358E-4 2.257E-3 1.226E-2 4.298E-2 2 57
8 cv:C2678497 Elliptocytosis 1 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
9 cv:C2675192 Spherocytosis type 5 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
10 OMIN:130600 ELLIPTOCYTOSIS 2; EL2 OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
11 OMIN:611804 ELLIPTOCYTOSIS 1; EL1 OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
12 C1851741 ELLIPTOCYTOSIS 2 (disorder) DisGeNET Curated 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
13 C2675192 Spherocytosis, Type 5 DisGeNET Curated 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
14 cv:C3150731 Early infantile epileptic encephalopathy 5 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
15 cv:C2678338 Spherocytosis type 3 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
16 OMIN:600224 SPINOCEREBELLAR ATAXIA 5; SCA5 OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
17 OMIN:266140 PYROPOIKILOCYTOSIS, HEREDITARY; HPP OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
18 OMIN:270970 SPHEROCYTOSIS, TYPE 3; SPH3 OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
19 OMIN:613477 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 5 OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
20 C3150731 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 5 DisGeNET Curated 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
21 cv:CN179771 Spinocerebellar ataxia, autosomal recessive 14 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
22 C2678338 SPHEROCYTOSIS, TYPE 3 (disorder) DisGeNET Curated 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
23 cv:C0520739 Hereditary pyropoikilocytosis Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
24 OMIN:612690 SPHEROCYTOSIS, TYPE 5; SPH5 OMIM 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
25 C2678497 Elliptocytosis 1 DisGeNET Curated 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
26 cv:C0752123 Spinocerebellar ataxia 5 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
27 cv:C1851741 Elliptocytosis 2 Clinical Variations 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
28 C3809327 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 14 DisGeNET Curated 4.937E-4 2.257E-3 1.226E-2
6.319E-2
 1 1
29 C0035435 Rheumatism DisGeNET BeFree 8.174E-4 3.608E-3 1.960E-2
1.046E-1
 2 89
30 C4020873 Infratentorial atrophy DisGeNET Curated 1.093E-3 4.662E-3 2.533E-2
1.399E-1
 2 103
31 C0472762 Alpha trait thalassemia DisGeNET BeFree 1.480E-3 6.113E-3 3.321E-2
1.895E-1
 1 3
32 C0740279 Atrophy of cerebellum DisGeNET Curated 1.733E-3 6.930E-3 3.765E-2
2.218E-1
 2 130
33 C0262404 Cerebellar degeneration DisGeNET Curated 1.894E-3 7.217E-3 3.921E-2
2.424E-1
 2 136
34 C0270871 Facial Myokymia DisGeNET Curated 1.973E-3 7.217E-3 3.921E-2
2.526E-1
 1 4
35 C4025285 Microspherocytosis DisGeNET Curated 1.973E-3 7.217E-3 3.921E-2
2.526E-1
 1 4
36 C1295585 Decreased vibratory sense DisGeNET Curated 3.451E-3 1.227E-2
6.667E-2
4.418E-1
 1 7
37 C0004134 Ataxia DisGeNET Curated 4.081E-3 1.385E-2
7.523E-2
5.223E-1
 2 201
38 C0151889 Hyperreflexia DisGeNET Curated 4.404E-3 1.385E-2
7.523E-2
5.637E-1
 2 209
39 20090116:Styrkarsdottir Bone mineral density (hip) GWAS 4.435E-3 1.385E-2
7.523E-2
5.677E-1
 1 9
40 20081125:Styrkarsdottir Bone mineral density (hip) GWAS 4.435E-3 1.385E-2
7.523E-2
5.677E-1
 1 9
41 C0272051 Xerocytosis DisGeNET Curated 4.435E-3 1.385E-2
7.523E-2
5.677E-1
 1 9
42 C0151450 Secondary Sj�gren's syndrome DisGeNET BeFree 4.927E-3 1.467E-2
7.969E-2
6.307E-1
 1 10
43 C0037952 Spinocerebellar Degeneration DisGeNET Curated 4.927E-3 1.467E-2
7.969E-2
6.307E-1
 1 10
44 C1527336 Sjogren's Syndrome DisGeNET Curated 5.042E-3 1.467E-2
7.969E-2
6.454E-1
 2 224
45 C1848924 Infantile onset DisGeNET Curated 5.674E-3 1.610E-2
8.745E-2
7.262E-1
 2 238
46 C1850808 Miyoshi myopathy DisGeNET Curated 5.910E-3 1.610E-2
8.745E-2
7.565E-1
 1 12
47 C0752123 Spinocerebellar Ataxia Type 5 DisGeNET Curated 5.910E-3 1.610E-2
8.745E-2
7.565E-1
 1 12
48 C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 6.340E-3 1.672E-2
9.085E-2
8.115E-1
 2 252
49 C2931919 X-linked infantile spasm syndrome DisGeNET BeFree 6.401E-3 1.672E-2
9.085E-2
8.193E-1
 1 13
50 C0271390 Nystagmus, End-Position DisGeNET Curated 6.892E-3 1.697E-2
9.217E-2
8.822E-1
 1 14
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