Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc17_12, positive side

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1: GO: Molecular Function [Display Chart] 12 input genes in category / 37 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004222 metalloendopeptidase activity 3.868E-11 1.431E-9 6.012E-9 1.431E-9 6 113
2 GO:0008191 metalloendopeptidase inhibitor activity 9.776E-11 1.809E-9 7.599E-9 3.617E-9 4 14
3 GO:0008237 metallopeptidase activity 8.482E-10 1.046E-8 4.395E-8 3.138E-8 6 188
4 GO:0004252 serine-type endopeptidase activity 1.903E-9 1.760E-8 7.394E-8 7.040E-8 6 215
5 GO:0008236 serine-type peptidase activity 3.871E-9 2.570E-8 1.080E-7 1.432E-7 6 242
6 GO:0017171 serine hydrolase activity 4.167E-9 2.570E-8 1.080E-7 1.542E-7 6 245
7 GO:0002020 protease binding 6.231E-9 3.293E-8 1.384E-7 2.305E-7 5 115
8 GO:0061134 peptidase regulator activity 1.686E-7 6.999E-7 2.941E-6 6.237E-6 5 222
9 GO:0004175 endopeptidase activity 1.702E-7 6.999E-7 2.941E-6 6.299E-6 6 457
10 GO:0001968 fibronectin binding 1.096E-6 4.057E-6 1.705E-5 4.057E-5 3 33
11 GO:0004866 endopeptidase inhibitor activity 3.182E-6 1.070E-5 4.497E-5 1.177E-4 4 171
12 GO:0061135 endopeptidase regulator activity 3.650E-6 1.110E-5 4.666E-5 1.350E-4 4 177
13 GO:0030414 peptidase inhibitor activity 3.901E-6 1.110E-5 4.666E-5 1.444E-4 4 180
14 GO:0005178 integrin binding 5.606E-5 1.482E-4 6.225E-4 2.074E-3 3 121
15 GO:0004857 enzyme inhibitor activity 8.387E-5 2.069E-4 8.693E-4 3.103E-3 4 393
16 GO:0050839 cell adhesion molecule binding 2.788E-4 6.448E-4 2.709E-3 1.032E-2 3 208
17 GO:0005518 collagen binding 9.450E-4 2.057E-3 8.642E-3 3.496E-2 2 72
18 GO:0048248 CXCR3 chemokine receptor binding 3.211E-3 6.601E-3 2.774E-2
1.188E-1
 1 5
19 GO:0008239 dipeptidyl-peptidase activity 8.330E-3 1.590E-2
6.682E-2
3.082E-1
 1 13
20 GO:0005125 cytokine activity 8.596E-3 1.590E-2
6.682E-2
3.181E-1
 2 222
21 GO:0045236 CXCR chemokine receptor binding 1.088E-2 1.917E-2
8.055E-2
4.026E-1
 1 17
22 GO:0050750 low-density lipoprotein particle receptor binding 1.152E-2 1.937E-2
8.138E-2
4.261E-1
 1 18
23 GO:0070325 lipoprotein particle receptor binding 1.469E-2 2.364E-2
9.932E-2
5.437E-1
 1 23
24 GO:0043425 bHLH transcription factor binding 1.913E-2 2.949E-2
1.239E-1
7.077E-1
 1 30
25 GO:0070888 E-box binding 2.228E-2 3.298E-2
1.386E-1
8.245E-1
 1 35
26 GO:0016504 peptidase activator activity 2.731E-2 3.829E-2
1.609E-1
1.000E0
 1 43
27 GO:0004177 aminopeptidase activity 2.794E-2 3.829E-2
1.609E-1
1.000E0
 1 44
28 GO:0008009 chemokine activity 3.044E-2 4.023E-2
1.690E-1
1.000E0
 1 48
29 GO:0042379 chemokine receptor binding 3.792E-2 4.838E-2
2.033E-1
1.000E0
 1 60
Show 24 more annotations

2: GO: Biological Process [Display Chart] 12 input genes in category / 733 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0022617 extracellular matrix disassembly 1.265E-16 9.276E-14 6.656E-13 9.276E-14 8 92
2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis 1.481E-12 3.827E-10 2.746E-9 1.086E-9 4 6
3 GO:0030574 collagen catabolic process 1.566E-12 3.827E-10 2.746E-9 1.148E-9 6 67
4 GO:0030198 extracellular matrix organization 7.301E-12 1.095E-9 7.855E-9 5.351E-9 8 354
5 GO:0043062 extracellular structure organization 7.467E-12 1.095E-9 7.855E-9 5.474E-9 8 355
6 GO:0032963 collagen metabolic process 6.248E-11 7.632E-9 5.476E-8 4.579E-8 6 122
7 GO:0051043 regulation of membrane protein ectodomain proteolysis 5.879E-10 6.156E-8 4.417E-7 4.309E-7 4 21
8 GO:0006509 membrane protein ectodomain proteolysis 1.092E-8 1.000E-6 7.176E-6 8.001E-6 4 42
9 GO:0033619 membrane protein proteolysis 3.311E-8 2.697E-6 1.935E-5 2.427E-5 4 55
10 GO:0052547 regulation of peptidase activity 9.884E-8 7.245E-6 5.198E-5 7.245E-5 6 416
11 GO:2000147 positive regulation of cell motility 1.745E-7 1.163E-5 8.345E-5 1.279E-4 6 458
12 GO:0051272 positive regulation of cellular component movement 2.033E-7 1.242E-5 8.911E-5 1.490E-4 6 470
13 GO:0040017 positive regulation of locomotion 2.218E-7 1.251E-5 8.975E-5 1.626E-4 6 477
14 GO:0010951 negative regulation of endopeptidase activity 2.779E-7 1.455E-5 1.044E-4 2.037E-4 5 245
15 GO:0010466 negative regulation of peptidase activity 3.523E-7 1.722E-5 1.235E-4 2.582E-4 5 257
16 GO:0042177 negative regulation of protein catabolic process 1.108E-6 5.076E-5 3.642E-4 8.122E-4 4 131
17 GO:0042698 ovulation cycle 1.364E-6 5.883E-5 4.221E-4 1.000E-3 4 138
18 GO:0045861 negative regulation of proteolysis 2.017E-6 7.782E-5 5.584E-4 1.479E-3 5 366
19 GO:0048511 rhythmic process 2.017E-6 7.782E-5 5.584E-4 1.479E-3 5 366
20 GO:0035987 endodermal cell differentiation 2.857E-6 9.983E-5 7.163E-4 2.094E-3 3 45
21 GO:0052548 regulation of endopeptidase activity 2.860E-6 9.983E-5 7.163E-4 2.097E-3 5 393
22 GO:0001503 ossification 3.274E-6 1.091E-4 7.828E-4 2.400E-3 5 404
23 GO:0051346 negative regulation of hydrolase activity 3.823E-6 1.218E-4 8.743E-4 2.802E-3 5 417
24 GO:0031330 negative regulation of cellular catabolic process 4.576E-6 1.398E-4 1.003E-3 3.354E-3 4 187
25 GO:0030335 positive regulation of cell migration 5.252E-6 1.540E-4 1.105E-3 3.850E-3 5 445
26 GO:0001706 endoderm formation 5.558E-6 1.567E-4 1.124E-3 4.074E-3 3 56
27 GO:0007566 embryo implantation 6.183E-6 1.678E-4 1.204E-3 4.532E-3 3 58
28 GO:0001525 angiogenesis 6.440E-6 1.686E-4 1.210E-3 4.721E-3 5 464
29 GO:0042493 response to drug 7.674E-6 1.940E-4 1.392E-3 5.625E-3 5 481
30 GO:1902532 negative regulation of intracellular signal transduction 8.398E-6 2.052E-4 1.472E-3 6.156E-3 5 490
31 GO:0048705 skeletal system morphogenesis 1.056E-5 2.497E-4 1.791E-3 7.740E-3 4 231
32 GO:0043627 response to estrogen 1.111E-5 2.519E-4 1.807E-3 8.144E-3 4 234
33 GO:0009612 response to mechanical stimulus 1.149E-5 2.519E-4 1.807E-3 8.423E-3 4 236
34 GO:0009895 negative regulation of catabolic process 1.168E-5 2.519E-4 1.807E-3 8.564E-3 4 237
35 GO:0044706 multi-multicellular organism process 1.442E-5 3.020E-4 2.167E-3 1.057E-2 4 250
36 GO:0007492 endoderm development 2.327E-5 4.738E-4 3.399E-3 1.706E-2 3 90
37 GO:0060349 bone morphogenesis 2.485E-5 4.924E-4 3.533E-3 1.822E-2 3 92
38 GO:0007568 aging 3.271E-5 6.309E-4 4.527E-3 2.398E-2 4 308
39 GO:0001666 response to hypoxia 3.440E-5 6.466E-4 4.639E-3 2.522E-2 4 312
40 GO:0036293 response to decreased oxygen levels 3.845E-5 7.045E-4 5.055E-3 2.818E-2 4 321
41 GO:0097094 craniofacial suture morphogenesis 3.978E-5 7.112E-4 5.103E-3 2.916E-2 2 15
42 GO:0022602 ovulation cycle process 4.243E-5 7.406E-4 5.314E-3 3.110E-2 3 110
43 GO:0070482 response to oxygen levels 4.703E-5 8.017E-4 5.752E-3 3.447E-2 4 338
44 GO:0001667 ameboidal-type cell migration 5.210E-5 8.680E-4 6.228E-3 3.819E-2 4 347
45 GO:0001704 formation of primary germ layer 5.922E-5 9.646E-4 6.921E-3 4.341E-2 3 123
46 GO:0008585 female gonad development 6.363E-5 1.014E-3 7.275E-3 4.664E-2 3 126
47 GO:0043200 response to amino acid 6.825E-5 1.064E-3 7.637E-3
5.003E-2
 3 129
48 GO:0046545 development of primary female sexual characteristics 7.144E-5 1.091E-3 7.828E-3
5.237E-2
 3 131
49 GO:0046660 female sex differentiation 9.860E-5 1.475E-3 1.058E-2
7.227E-2
 3 146
50 GO:0042176 regulation of protein catabolic process 1.034E-4 1.516E-3 1.088E-2
7.581E-2
 4 414
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 12 input genes in category / 40 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 3.854E-13 1.542E-11 6.595E-11 1.542E-11 9 444
2 GO:0005604 basement membrane 3.854E-5 7.709E-4 3.298E-3 1.542E-3 3 109
3 GO:0044420 extracellular matrix component 8.302E-5 1.107E-3 4.736E-3 3.321E-3 3 141
4 GO:0034774 secretory granule lumen 1.260E-3 1.260E-2
5.391E-2
5.040E-2
 2 85
5 GO:0060205 cytoplasmic vesicle lumen 1.878E-3 1.349E-2
5.770E-2
7.511E-2
 2 104
6 GO:0031983 vesicle lumen 2.023E-3 1.349E-2
5.770E-2
8.092E-2
 2 108
7 GO:0071438 invadopodium membrane 3.772E-3 1.676E-2
7.173E-2
1.509E-1
 1 6
8 GO:0044352 pinosome 3.772E-3 1.676E-2
7.173E-2
1.509E-1
 1 6
9 GO:0044354 macropinosome 3.772E-3 1.676E-2
7.173E-2
1.509E-1
 1 6
10 GO:0046581 intercellular canaliculus 5.653E-3 2.261E-2
9.675E-2
2.261E-1
 1 9
11 GO:0030017 sarcomere 6.617E-3 2.283E-2
9.769E-2
2.647E-1
 2 198
12 GO:0071437 invadopodium 7.531E-3 2.283E-2
9.769E-2
3.012E-1
 1 12
13 GO:0044449 contractile fiber part 7.759E-3 2.283E-2
9.769E-2
3.103E-1
 2 215
14 GO:0030016 myofibril 8.110E-3 2.283E-2
9.769E-2
3.244E-1
 2 220
15 GO:0031089 platelet dense granule lumen 8.781E-3 2.283E-2
9.769E-2
3.512E-1
 1 14
16 GO:0043292 contractile fiber 9.133E-3 2.283E-2
9.769E-2
3.653E-1
 2 234
17 GO:0031258 lamellipodium membrane 1.190E-2 2.783E-2
1.191E-1
4.760E-1
 1 19
18 GO:0042827 platelet dense granule 1.252E-2 2.783E-2
1.191E-1
5.009E-1
 1 20
19 GO:0005925 focal adhesion 2.441E-2 4.651E-2
1.990E-1
9.765E-1
 2 393
20 GO:0005924 cell-substrate adherens junction 2.499E-2 4.651E-2
1.990E-1
9.998E-1
 2 398
21 GO:0030141 secretory granule 2.523E-2 4.651E-2
1.990E-1
1.000E0
 2 400
22 GO:0030055 cell-substrate junction 2.558E-2 4.651E-2
1.990E-1
1.000E0
 2 403
Show 17 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 462 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004039 Abnormality of ulnar metaphysis 1.352E-5 4.894E-3 3.286E-2 6.246E-3 2 5
2 HP:0003016 Metaphyseal widening 2.119E-5 4.894E-3 3.286E-2 9.788E-3 4 166
3 HP:0009139 Osteolysis involving bones of the lower limbs 8.888E-5 8.084E-3
5.427E-2
 4.106E-2 2 12
4 HP:0009134 Osteolysis involving bones of the feet 8.888E-5 8.084E-3
5.427E-2
 4.106E-2 2 12
5 HP:0000944 Abnormality of the metaphysis 9.578E-5 8.084E-3
5.427E-2
 4.425E-2 4 243
6 HP:0009809 Abnormality of upper limb metaphysis 1.050E-4 8.084E-3
5.427E-2
 4.850E-2 2 13
7 HP:0031013 Ankylosis 1.412E-4 9.317E-3
6.255E-2
6.522E-2
 2 15
8 HP:0001376 Limitation of joint mobility 1.945E-4 1.123E-2
7.540E-2
8.984E-2
 4 291
9 HP:0045039 Osteolysis involving bones of the upper limbs 3.386E-4 1.738E-2
1.167E-1
1.564E-1
 2 23
10 HP:0002997 Abnormality of the ulna 5.030E-4 2.324E-2
1.560E-1
2.324E-1
 3 142
11 HP:0002818 Abnormality of the radius 8.251E-4 2.804E-2
1.883E-1
3.812E-1
 3 168
12 HP:0006012 Widened metacarpal shaft 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
13 HP:0008476 Irregular sclerotic endplates 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
14 HP:0004566 Pear-shaped vertebrae 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
15 HP:0005441 Sclerotic cranial sutures 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
16 HP:0006252 Interphalangeal joint erosions 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
17 HP:0008090 Ankylosis of feet small joints 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
18 HP:0006603 Flared, irregular rib ends 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
19 HP:0006409 Progressive leg bowing 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
20 HP:0008078 Thin metatarsal cortices 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
21 HP:0008133 Distal tapering of metatarsals 1.275E-3 2.804E-2
1.883E-1
5.889E-1
 1 1
22 HP:0040072 Abnormality of forearm bone 1.354E-3 2.842E-2
1.908E-1
6.258E-1
 3 199
23 HP:0002973 Abnormality of the forearm 1.415E-3 2.842E-2
1.908E-1
6.537E-1
 3 202
24 HP:0006086 Thin metacarpal cortices 2.548E-3 3.837E-2
2.576E-1
1.000E0
 1 2
25 HP:0001473 Metatarsal osteolysis 2.548E-3 3.837E-2
2.576E-1
1.000E0
 1 2
26 HP:0001504 Metacarpal osteolysis 2.548E-3 3.837E-2
2.576E-1
1.000E0
 1 2
27 HP:0006383 Progressive bowing of long bones 2.548E-3 3.837E-2
2.576E-1
1.000E0
 1 2
28 HP:0040065 Abnormal morphology of bones of the upper limbs 3.493E-3 3.837E-2
2.576E-1
1.000E0
 3 276
29 HP:0009948 Duplication of the distal phalanx of the 2nd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
30 HP:0006385 Short lower limbs 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
31 HP:0009968 Partial duplication of the distal phalanx of the 3rd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
32 HP:0006234 Osteolysis involving tarsal bones 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
33 HP:0010108 Aplasia of the hallux 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
34 HP:0009956 Partial duplication of the phalanges of the 2nd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
35 HP:0009962 Duplication of the distal phalanx of the 3rd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
36 HP:0001495 Carpal osteolysis 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
37 HP:0009961 Partial duplication of the phalanges of the 3rd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
38 HP:0009945 Duplication of phalanx of 2nd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
39 HP:0010110 Aplasia of the phalanges of the hallux 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
40 HP:0009899 Prominent crus of helix 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
41 HP:0011323 Cleft of chin 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
42 HP:0009958 Polydactyly affecting the 3rd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
43 HP:0010104 Absent first metatarsal 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
44 HP:0009951 Partial duplication of the distal phalanx of the 2nd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
45 HP:0009946 Polydactyly affecting the 2nd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
46 HP:0009959 Duplication of phalanx of 3rd finger 3.820E-3 3.837E-2
2.576E-1
1.000E0
 1 3
47 HP:0000270 Delayed cranial suture closure 4.298E-3 4.224E-2
2.836E-1
1.000E0
 2 82
48 HP:0006501 Aplasia/Hypoplasia of the radius 4.719E-3 4.276E-2
2.871E-1
1.000E0
 2 86
49 HP:0006493 Aplasia/hypoplasia involving bones of the lower limbs 4.784E-3 4.276E-2
2.871E-1
1.000E0
 3 308
50 HP:0000212 Gingival overgrowth 4.937E-3 4.276E-2
2.871E-1
1.000E0
 2 88
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 11 input genes in category / 706 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006237 abnormal choroid vasculature morphology 1.561E-6 5.718E-4 4.081E-3 1.102E-3 3 23
2 MP:0000343 altered response to myocardial infarction 1.681E-6 5.718E-4 4.081E-3 1.187E-3 4 90
3 MP:0006278 aortic aneurysm 2.573E-6 5.718E-4 4.081E-3 1.816E-3 3 27
4 MP:0002411 decreased susceptibility to bacterial infection 3.240E-6 5.718E-4 4.081E-3 2.287E-3 4 106
5 MP:0002993 arthritis 1.009E-5 1.334E-3 9.524E-3 7.127E-3 4 141
6 MP:0001183 overexpanded pulmonary alveoli 1.153E-5 1.334E-3 9.524E-3 8.143E-3 3 44
7 MP:0002933 joint inflammation 1.359E-5 1.334E-3 9.524E-3 9.597E-3 4 152
8 MP:0000736 delayed muscle development 1.535E-5 1.334E-3 9.524E-3 1.084E-2 2 6
9 MP:0003408 increased width of hypertrophic chondrocyte zone 1.701E-5 1.334E-3 9.524E-3 1.201E-2 3 50
10 MP:0010139 aortitis 2.148E-5 1.517E-3 1.083E-2 1.517E-2 2 7
11 MP:0005098 abnormal optic choroid morphology 2.397E-5 1.539E-3 1.098E-2 1.693E-2 3 56
12 MP:0003279 aneurysm 2.807E-5 1.651E-3 1.179E-2 1.982E-2 3 59
13 MP:0002908 delayed wound healing 3.421E-5 1.699E-3 1.212E-2 2.415E-2 3 63
14 MP:0010659 abdominal aorta aneurysm 3.679E-5 1.699E-3 1.212E-2 2.597E-2 2 9
15 MP:0002409 decreased susceptibility to infection 3.777E-5 1.699E-3 1.212E-2 2.666E-2 4 197
16 MP:0000559 abnormal femur morphology 4.007E-5 1.699E-3 1.212E-2 2.829E-2 4 200
17 MP:0000260 abnormal angiogenesis 4.281E-5 1.699E-3 1.212E-2 3.023E-2 5 425
18 MP:0003856 abnormal hindlimb stylopod morphology 4.331E-5 1.699E-3 1.212E-2 3.058E-2 4 204
19 MP:0008271 abnormal bone ossification 5.456E-5 1.835E-3 1.309E-2 3.852E-2 5 447
20 MP:0009870 abnormal abdominal aorta morphology 5.613E-5 1.835E-3 1.309E-2 3.963E-2 2 11
21 MP:0003434 decreased susceptibility to induced choroidal neovascularization 5.613E-5 1.835E-3 1.309E-2 3.963E-2 2 11
22 MP:0000550 abnormal forelimb morphology 5.717E-5 1.835E-3 1.309E-2 4.036E-2 4 219
23 MP:0006399 abnormal long bone epiphyseal ossification zone morphology 6.732E-5 2.067E-3 1.475E-2 4.753E-2 2 12
24 MP:0002268 abnormal terminal bronchiole morphology 9.272E-5 2.727E-3 1.947E-2
6.546E-2
 2 14
25 MP:0005602 decreased angiogenesis 1.323E-4 3.736E-3 2.667E-2
9.341E-2
 3 99
26 MP:0005546 choroidal neovascularization 1.555E-4 4.223E-3 3.014E-2
1.098E-1
 2 18
27 MP:0000733 abnormal muscle development 1.666E-4 4.358E-3 3.110E-2
1.177E-1
 3 107
28 MP:0010138 arteritis 1.737E-4 4.380E-3 3.126E-2
1.226E-1
 2 19
29 MP:0000130 abnormal trabecular bone morphology 1.940E-4 4.723E-3 3.371E-2
1.370E-1
 4 300
30 MP:0005296 abnormal humerus morphology 2.227E-4 5.240E-3 3.740E-2
1.572E-1
 3 118
31 MP:0009869 abnormal descending aorta morphology 2.343E-4 5.335E-3 3.808E-2
1.654E-1
 2 22
32 MP:0003854 abnormal forelimb stylopod morphology 2.517E-4 5.486E-3 3.916E-2
1.777E-1
 3 123
33 MP:0009660 abnormal induced retinal neovascularization 2.564E-4 5.486E-3 3.916E-2
1.810E-1
 2 23
34 MP:0003109 short femur 2.964E-4 6.119E-3 4.367E-2
2.092E-1
 3 130
35 MP:0020186 altered susceptibility to bacterial infection 3.033E-4 6.119E-3 4.367E-2
2.141E-1
 4 337
36 MP:0030825 decreased femur size 3.170E-4 6.216E-3 4.437E-2
2.238E-1
 3 133
37 MP:0009763 increased sensitivity to induced morbidity/mortality 3.430E-4 6.545E-3 4.672E-2
2.422E-1
 4 348
38 MP:0000322 increased granulocyte number 3.742E-4 6.951E-3 4.962E-2
2.642E-1
 4 356
39 MP:0000060 delayed bone ossification 4.087E-4 7.264E-3
5.185E-2
2.885E-1
 3 145
40 MP:0004686 decreased length of long bones 4.116E-4 7.264E-3
5.185E-2
2.906E-1
 4 365
41 MP:0000165 abnormal long bone hypertrophic chondrocyte zone 4.340E-4 7.381E-3
5.268E-2
3.064E-1
 3 148
42 MP:0000761 thin diaphragm muscle 4.391E-4 7.381E-3
5.268E-2
3.100E-1
 2 30
43 MP:0005595 abnormal vascular smooth muscle physiology 5.257E-4 8.630E-3
6.160E-2
3.711E-1
 3 158
44 MP:0004986 abnormal osteoblast morphology 5.454E-4 8.671E-3
6.189E-2
3.850E-1
 3 160
45 MP:0003358 abnormal hypaxial muscle morphology 5.554E-4 8.671E-3
6.189E-2
3.921E-1
 3 161
46 MP:0001864 vasculitis 5.650E-4 8.671E-3
6.189E-2
3.989E-1
 2 34
47 MP:0001176 abnormal lung development 6.073E-4 9.123E-3
6.512E-2
4.288E-1
 3 166
48 MP:0000163 abnormal cartilage morphology 6.403E-4 9.418E-3
6.722E-2
4.521E-1
 4 410
49 MP:0002792 abnormal retinal vasculature morphology 6.968E-4 9.994E-3
7.133E-2
4.919E-1
 3 174
50 MP:0000249 abnormal blood vessel physiology 7.078E-4 9.994E-3
7.133E-2
4.997E-1
 4 421
Show 45 more annotations

6: Domain [Display Chart] 12 input genes in category / 73 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR030490 TIMP CS InterPro 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
2 PF00965 TIMP Pfam 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
3 3.90.370.10 - Gene3D 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
4 IPR001820 TIMP InterPro 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
5 SM00206 NTR SMART 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
6 PS00288 TIMP PROSITE 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
7 IPR027465 TIMP C InterPro 9.646E-14 1.006E-12 4.903E-12 7.041E-12 4 4
8 IPR021158 Pept M10A Zn BS InterPro 1.233E-13 1.125E-12 5.486E-12 9.003E-12 5 15
9 IPR018486 Hemopexin CS InterPro 2.540E-13 2.060E-12 1.004E-11 1.854E-11 5 17
10 IPR002477 Peptidoglycan-bd-like InterPro 6.357E-13 4.219E-12 2.057E-11 4.641E-11 5 20
11 PF01471 PG binding 1 Pfam 6.357E-13 4.219E-12 2.057E-11 4.641E-11 5 20
12 IPR033739 M10A MMP InterPro 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
13 PS51642 HEMOPEXIN 2 PROSITE 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
14 SM00120 HX SMART 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
15 2.110.10.10 - Gene3D 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
16 IPR018487 Hemopexin-like repeat InterPro 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
17 PS00024 HEMOPEXIN PROSITE 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
18 IPR000585 Hemopexin-like dom InterPro 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
19 IPR021190 Pept M10A InterPro 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
20 PF00045 Hemopexin Pfam 1.378E-12 5.032E-12 2.453E-11 1.006E-10 5 23
21 PF00413 Peptidase M10 Pfam 1.741E-12 6.051E-12 2.950E-11 1.271E-10 5 24
22 SM00235 ZnMc SMART 4.856E-12 1.541E-11 7.513E-11 3.545E-10 5 29
23 IPR006026 Peptidase Metallo InterPro 4.856E-12 1.541E-11 7.513E-11 3.545E-10 5 29
24 PS00546 CYSTEINE SWITCH PROSITE 3.053E-11 9.286E-11 4.526E-10 2.229E-9 5 41
25 IPR001818 Pept M10 metallopeptidase InterPro 3.919E-11 1.144E-10 5.578E-10 2.861E-9 5 43
26 PS50189 NTR PROSITE 8.486E-10 2.294E-9 1.118E-8 6.195E-8 4 23
27 IPR001134 Netrin domain InterPro 8.486E-10 2.294E-9 1.118E-8 6.195E-8 4 23
28 3.40.390.10 - Gene3D 1.031E-9 2.595E-9 1.265E-8 7.525E-8 5 81
29 IPR024079 MetalloPept cat dom InterPro 1.031E-9 2.595E-9 1.265E-8 7.525E-8 5 81
30 IPR008993 TIMP-like OB-fold InterPro 1.431E-9 3.483E-9 1.698E-8 1.045E-7 4 26
31 PS00142 ZINC PROTEASE PROSITE 2.718E-9 6.400E-9 3.120E-8 1.984E-7 5 98
32 IPR016293 Pept M10A stromelysin-type InterPro 1.629E-7 3.717E-7 1.812E-6 1.189E-5 3 18
33 2.10.10.10 - Gene3D 2.922E-5 6.464E-5 3.151E-4 2.133E-3 2 13
34 PF00040 fn2 Pfam 3.408E-5 6.547E-5 3.191E-4 2.488E-3 2 14
35 PS00023 FN2 1 PROSITE 3.408E-5 6.547E-5 3.191E-4 2.488E-3 2 14
36 PS51092 FN2 2 PROSITE 3.408E-5 6.547E-5 3.191E-4 2.488E-3 2 14
37 IPR000562 FN type2 col-bd InterPro 3.408E-5 6.547E-5 3.191E-4 2.488E-3 2 14
38 SM00059 FN2 SMART 3.408E-5 6.547E-5 3.191E-4 2.488E-3 2 14
39 IPR013806 Kringle-like InterPro 1.846E-4 3.455E-4 1.684E-3 1.347E-2 2 32
40 IPR028711 Collagenase 3 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
41 IPR028708 72kDa collagenase InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
42 IPR015612 TIMP3 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
43 IPR028693 MMP14 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
44 IPR027225 CXCL9 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
45 IPR015611 TIMP1 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
46 IPR028700 Stromelysin 1 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
47 IPR028688 MMP9 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
48 IPR015613 TIMP2 InterPro 6.405E-4 9.741E-4 4.748E-3 4.676E-2 1 1
49 IPR015789 Twist-related InterPro 1.281E-3 1.908E-3 9.300E-3
9.349E-2
 1 2
50 PF11857 DUF3377 Pfam 2.560E-3 3.526E-3 1.719E-2
1.869E-1
 1 4
Show 45 more annotations

7: Pathway [Display Chart] 11 input genes in category / 71 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270258 Activation of Matrix Metalloproteinases BioSystems: REACTOME 1.524E-16 1.082E-14 5.244E-14 1.082E-14 7 33
2 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 1.561E-14 5.540E-13 2.685E-12 1.108E-12 9 238
3 1270257 Degradation of the extracellular matrix BioSystems: REACTOME 1.264E-12 2.991E-11 1.450E-10 8.973E-11 7 112
4 1270259 Collagen degradation BioSystems: REACTOME 1.370E-10 2.432E-9 1.179E-8 9.728E-9 5 41
5 1270244 Extracellular matrix organization BioSystems: REACTOME 1.276E-9 1.812E-8 8.782E-8 9.059E-8 7 298
6 1470923 Interleukin-4 and 13 signaling BioSystems: REACTOME 2.606E-8 3.084E-7 1.495E-6 1.850E-6 5 114
7 P00050 Plasminogen activating cascade PantherDB 3.466E-7 3.515E-6 1.704E-5 2.461E-5 3 17
8 P00004 Alzheimer disease-presenilin pathway PantherDB 2.022E-6 1.794E-5 8.696E-5 1.435E-4 4 113
9 1270247 Assembly of collagen fibrils and other multimeric structures BioSystems: REACTOME 1.708E-5 1.348E-4 6.532E-4 1.213E-3 3 60
10 782000 Proteoglycans in cancer BioSystems: KEGG 2.070E-5 1.470E-4 7.125E-4 1.470E-3 4 203
11 1474301 IL-17 signaling pathway BioSystems: KEGG 6.376E-5 3.772E-4 1.828E-3 4.527E-3 3 93
12 1270245 Collagen formation BioSystems: REACTOME 6.376E-5 3.772E-4 1.828E-3 4.527E-3 3 93
13 812256 TNF signaling pathway BioSystems: KEGG 9.958E-5 5.439E-4 2.636E-3 7.070E-3 3 108
14 138009 Plasma membrane estrogen receptor signaling BioSystems: Pathway Interaction Database 2.280E-4 1.156E-3 5.605E-3 1.619E-2 2 26
15 137960 Osteopontin-mediated events BioSystems: Pathway Interaction Database 3.470E-4 1.637E-3 7.936E-3 2.463E-2 2 32
16 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 3.921E-4 1.637E-3 7.936E-3 2.784E-2 2 34
17 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 3.921E-4 1.637E-3 7.936E-3 2.784E-2 2 34
18 83115 Bladder cancer BioSystems: KEGG 5.711E-4 2.253E-3 1.092E-2 4.055E-2 2 41
19 137945 amb2 Integrin signaling BioSystems: Pathway Interaction Database 7.830E-4 2.780E-3 1.347E-2
5.559E-2
 2 48
20 1270334 EPH-ephrin mediated repulsion of cells BioSystems: REACTOME 7.830E-4 2.780E-3 1.347E-2
5.559E-2
 2 48
21 137928 LPA receptor mediated events BioSystems: Pathway Interaction Database 1.432E-3 4.842E-3 2.347E-2
1.017E-1
 2 65
22 169352 Regulation of Wnt-mediated beta catenin signaling and target gene transcription BioSystems: Pathway Interaction Database 2.107E-3 6.800E-3 3.296E-2
1.496E-1
 2 79
23 83091 GnRH signaling pathway BioSystems: KEGG 2.845E-3 8.782E-3 4.256E-2
2.020E-1
 2 92
24 1270330 EPH-Ephrin signaling BioSystems: REACTOME 3.030E-3 8.784E-3 4.258E-2
2.151E-1
 2 95
25 1404799 Endocrine resistance BioSystems: KEGG 3.093E-3 8.784E-3 4.258E-2
2.196E-1
 2 96
26 799177 Estrogen signaling pathway BioSystems: KEGG 3.221E-3 8.795E-3 4.263E-2
2.287E-1
 2 98
27 83083 Leukocyte transendothelial migration BioSystems: KEGG 4.331E-3 1.139E-2
5.520E-2
3.075E-1
 2 114
28 1269367 Platelet degranulation BioSystems: REACTOME 5.763E-3 1.461E-2
7.084E-2
4.092E-1
 2 132
29 1269365 Response to elevated platelet cytosolic Ca2+ BioSystems: REACTOME 6.195E-3 1.517E-2
7.352E-2
4.399E-1
 2 137
30 1474302 Fluid shear stress and atherosclerosis BioSystems: KEGG 6.641E-3 1.572E-2
7.618E-2
4.715E-1
 2 142
31 1269593 EGFR Transactivation by Gastrin BioSystems: REACTOME 7.926E-3 1.815E-2
8.799E-2
5.628E-1
 1 9
32 523016 Transcriptional misregulation in cancer BioSystems: KEGG 1.049E-2 2.328E-2
1.128E-1
7.450E-1
 2 180
33 M14863 p53 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.405E-2 3.023E-2
1.465E-1
9.977E-1
 1 16
34 138046 Syndecan-1-mediated signaling events BioSystems: Pathway Interaction Database 1.492E-2 3.027E-2
1.467E-1
1.000E0
 1 17
35 M11358 Tumor Suppressor Arf Inhibits Ribosomal Biogenesis MSigDB C2 BIOCARTA (v6.0) 1.492E-2 3.027E-2
1.467E-1
1.000E0
 1 17
36 1268755 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) BioSystems: REACTOME 1.841E-2 3.630E-2
1.759E-1
1.000E0
 1 21
37 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 2.457E-2 4.715E-2
2.285E-1
1.000E0
 2 282
38 138064 Syndecan-4-mediated signaling events BioSystems: Pathway Interaction Database 2.706E-2 4.988E-2
2.418E-1
1.000E0
 1 31
39 852705 MicroRNAs in cancer BioSystems: KEGG 2.740E-2 4.988E-2
2.418E-1
1.000E0
 2 299
Show 34 more annotations

8: Pubmed [Display Chart] 12 input genes in category / 8318 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11359935 TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Pubmed 2.541E-32 2.114E-28 2.030E-27 2.114E-28 9 11
2 20484597 Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families. Pubmed 5.284E-30 2.198E-26 2.110E-25 4.395E-26 9 16
3 12815621 Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development. Pubmed 5.675E-27 1.573E-23 1.511E-22 4.720E-23 8 13
4 9291579 Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period. Pubmed 3.369E-26 5.605E-23 5.383E-22 2.802E-22 7 7
5 10985432 Temporospatial distribution of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinases during murine secondary palate morphogenesis. Pubmed 3.369E-26 5.605E-23 5.383E-22 2.802E-22 7 7
6 20587546 Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. Pubmed 4.342E-26 6.020E-23 5.781E-22 3.612E-22 9 36
7 22014525 ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Pubmed 3.331E-25 3.958E-22 3.801E-21 2.771E-21 8 19
8 9108368 Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. Pubmed 1.213E-24 1.261E-21 1.211E-20 1.009E-20 7 9
9 15944607 Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. Pubmed 5.777E-23 5.340E-20 5.128E-19 4.806E-19 7 13
10 25636537 Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation. Pubmed 1.155E-22 9.610E-20 9.229E-19 9.610E-19 7 14
11 12950084 Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development. Pubmed 2.144E-22 1.501E-19 1.442E-18 1.784E-18 6 6
12 18639653 uPARAP expression during murine lung development. Pubmed 2.166E-22 1.501E-19 1.442E-18 1.802E-18 7 15
13 24373743 Biglycan and decorin differentially regulate signaling in the fetal membranes. Pubmed 3.850E-22 2.464E-19 2.366E-18 3.203E-18 7 16
14 10731089 Occurrence and temporal variation in matrix metalloproteinases and their inhibitors during murine secondary palatal morphogenesis. Pubmed 1.501E-21 7.802E-19 7.493E-18 1.248E-17 6 7
15 17893005 Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. Pubmed 1.501E-21 7.802E-19 7.493E-18 1.248E-17 6 7
16 25300296 Overexpression of matrix metalloproteinases in lung tissue of patients with primary spontaneous pneumothorax. Pubmed 1.501E-21 7.802E-19 7.493E-18 1.248E-17 6 7
17 25920569 APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Pubmed 2.608E-21 1.276E-18 1.225E-17 2.169E-17 7 20
18 8674412 Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Pubmed 6.002E-21 2.628E-18 2.524E-17 4.993E-17 6 8
19 11865039 Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2. Pubmed 6.002E-21 2.628E-18 2.524E-17 4.993E-17 6 8
20 16113801 Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Pubmed 1.800E-20 7.131E-18 6.849E-17 1.498E-16 6 9
21 11675412 Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. Pubmed 1.800E-20 7.131E-18 6.849E-17 1.498E-16 6 9
22 19339693 Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
23 10232461 Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
24 26979530 Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
25 16469749 Individual Timp deficiencies differentially impact pro-MMP-2 activation. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
26 7626795 92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
27 20948207 Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
28 18291374 Human chorionic gonadotropin stimulates matrix metalloproteinases-2 and -9 in cytotrophoblastic cells and decreases tissue inhibitor of metalloproteinases-1, -2, and -3 in decidualized endometrial stromal cells. Pubmed 1.170E-18 3.475E-16 3.337E-15 9.730E-15 5 5
29 11165481 A molecular analysis of matrix remodeling and angiogenesis during long bone development. Pubmed 2.650E-18 7.600E-16 7.299E-15 2.204E-14 6 17
30 15063736 Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. Pubmed 5.808E-18 1.610E-15 1.546E-14 4.831E-14 6 19
31 22200690 Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Pubmed 7.018E-18 1.668E-15 1.602E-14 5.837E-14 5 6
32 19020757 Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. Pubmed 7.018E-18 1.668E-15 1.602E-14 5.837E-14 5 6
33 19551542 In vitro study of matrix metalloproteinase/tissue inhibitor of metalloproteinase production by mesenchymal stromal cells in response to inflammatory cytokines: the role of their migration in injured tissues. Pubmed 7.018E-18 1.668E-15 1.602E-14 5.837E-14 5 6
34 17901377 Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness. Pubmed 7.018E-18 1.668E-15 1.602E-14 5.837E-14 5 6
35 20616161 Functional polymorphisms in matrix metalloproteinases-1, -3, -9 are associated with arteriovenous fistula patency in hemodialysis patients. Pubmed 7.018E-18 1.668E-15 1.602E-14 5.837E-14 5 6
36 15734845 Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo. Pubmed 1.161E-17 2.683E-15 2.577E-14 9.659E-14 6 21
37 17589947 Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. Pubmed 2.456E-17 4.982E-15 4.785E-14 2.043E-13 5 7
38 10090151 Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation. Pubmed 2.456E-17 4.982E-15 4.785E-14 2.043E-13 5 7
39 17564313 Expression of matrix metalloproiteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in hepatocellular carcinoma tissue, compared with the surrounding non-tumor tissue. Pubmed 2.456E-17 4.982E-15 4.785E-14 2.043E-13 5 7
40 19542530 Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. Pubmed 2.456E-17 4.982E-15 4.785E-14 2.043E-13 5 7
41 17033924 Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression. Pubmed 2.456E-17 4.982E-15 4.785E-14 2.043E-13 5 7
42 20628624 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". Pubmed 6.997E-17 1.386E-14 1.331E-13 5.820E-13 8 172
43 20672350 Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. Pubmed 4.160E-16 8.047E-14 7.727E-13 3.460E-12 6 36
44 10949577 Matrix metalloproteinases in tumor invasion. Pubmed 5.101E-15 4.645E-13 4.461E-12 4.243E-11 5 16
45 25805621 The role of TIMPs in regulation of extracellular matrix proteolysis. Pubmed 5.584E-15 4.645E-13 4.461E-12 4.645E-11 4 4
46 28192449 TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model. Pubmed 5.584E-15 4.645E-13 4.461E-12 4.645E-11 4 4
47 10225966 Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. Pubmed 5.584E-15 4.645E-13 4.461E-12 4.645E-11 4 4
48 28798935 Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia. Pubmed 5.584E-15 4.645E-13 4.461E-12 4.645E-11 4 4
49 22204652 Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation. Pubmed 5.584E-15 4.645E-13 4.461E-12 4.645E-11 4 4
50 25150980 Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Pubmed 5.584E-15 4.645E-13 4.461E-12 4.645E-11 4 4
Show 45 more annotations

9: Interaction [Display Chart] 12 input genes in category / 212 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MMP14 MMP14 interactions 6.415E-21 1.360E-18 8.073E-18 1.360E-18 8 28
2 int:TIMP3 TIMP3 interactions 8.639E-18 9.157E-16 5.436E-15 1.831E-15 7 28
3 int:TIMP1 TIMP1 interactions 2.380E-13 1.682E-11 9.985E-11 5.046E-11 5 16
4 int:MMP2 MMP2 interactions 7.734E-13 4.099E-11 2.433E-10 1.640E-10 6 57
5 int:TIMP2 TIMP2 interactions 2.193E-10 9.297E-9 5.519E-8 4.648E-8 4 16
6 int:CCL7 CCL7 interactions 3.684E-10 1.302E-8 7.727E-8 7.810E-8 4 18
7 int:TIMP4 TIMP4 interactions 9.515E-10 2.882E-8 1.711E-7 2.017E-7 3 4
8 int:SPOCK1 SPOCK1 interactions 2.378E-9 6.301E-8 3.740E-7 5.041E-7 3 5
9 int:MMP3 MMP3 interactions 2.848E-9 6.708E-8 3.982E-7 6.038E-7 4 29
10 int:KISS1 KISS1 interactions 1.330E-8 2.820E-7 1.674E-6 2.820E-6 3 8
11 int:HAPLN1 HAPLN1 interactions 1.994E-8 3.844E-7 2.282E-6 4.228E-6 3 9
12 int:MMP13 MMP13 interactions 2.848E-8 5.031E-7 2.987E-6 6.038E-6 3 10
13 int:BCAN BCAN interactions 1.326E-7 2.162E-6 1.284E-5 2.811E-5 3 16
14 int:MMP10 MMP10 interactions 1.610E-7 2.437E-6 1.447E-5 3.412E-5 3 17
15 int:ACAN ACAN interactions 1.931E-7 2.729E-6 1.620E-5 4.093E-5 3 18
16 int:MMP9 MMP9 interactions 3.103E-6 3.869E-5 2.297E-4 6.578E-4 3 44
17 int:COL2A1 COL2A1 interactions 3.103E-6 3.869E-5 2.297E-4 6.578E-4 3 44
18 int:SPOCK3 SPOCK3 interactions 4.207E-6 4.695E-5 2.787E-4 8.920E-4 2 5
19 int:COL12A1 COL12A1 interactions 4.207E-6 4.695E-5 2.787E-4 8.920E-4 2 5
20 int:PZP PZP interactions 2.770E-5 2.936E-4 1.743E-3 5.871E-3 2 12
21 int:CLDN1 CLDN1 interactions 3.272E-5 3.303E-4 1.961E-3 6.936E-3 2 13
22 int:THBS2 THBS2 interactions 4.401E-5 4.241E-4 2.518E-3 9.330E-3 2 15
23 int:COL4A6 COL4A6 interactions 6.406E-5 5.905E-4 3.505E-3 1.358E-2 2 18
24 int:LCN2 LCN2 interactions 8.782E-5 7.758E-4 4.605E-3 1.862E-2 2 21
25 int:F12 F12 interactions 1.057E-4 8.621E-4 5.118E-3 2.241E-2 2 23
26 int:DPP4 DPP4 interactions 1.057E-4 8.621E-4 5.118E-3 2.241E-2 2 23
27 int:IGFBP1 IGFBP1 interactions 1.253E-4 9.836E-4 5.839E-3 2.656E-2 2 25
28 int:COL5A1 COL5A1 interactions 1.693E-4 1.281E-3 7.606E-3 3.589E-2 2 29
29 int:IGFBP3 IGFBP3 interactions 1.813E-4 1.281E-3 7.606E-3 3.844E-2 2 30
30 int:COL6A2 COL6A2 interactions 1.813E-4 1.281E-3 7.606E-3 3.844E-2 2 30
31 int:COL6A1 COL6A1 interactions 1.937E-4 1.325E-3 7.865E-3 4.107E-2 2 31
32 int:COL18A1 COL18A1 interactions 2.066E-4 1.327E-3 7.878E-3 4.379E-2 2 32
33 int:COL14A1 COL14A1 interactions 2.066E-4 1.327E-3 7.878E-3 4.379E-2 2 32
34 int:COL4A1 COL4A1 interactions 2.335E-4 1.456E-3 8.642E-3 4.950E-2 2 34
35 int:DCN DCN interactions 2.620E-4 1.587E-3 9.420E-3
5.554E-2
 2 36
36 int:EPHB2 EPHB2 interactions 4.670E-4 2.750E-3 1.632E-2
9.900E-2
 2 48
37 int:COL4A2 COL4A2 interactions 5.481E-4 3.141E-3 1.864E-2
1.162E-1
 2 52
38 int:THBS1 THBS1 interactions 5.911E-4 3.298E-3 1.957E-2
1.253E-1
 2 54
39 int:PLG PLG interactions 9.088E-4 4.940E-3 2.933E-2
1.927E-1
 2 67
40 int:COL1A1 COL1A1 interactions 1.020E-3 5.405E-3 3.209E-2
2.162E-1
 2 71
41 int:ITGAV ITGAV interactions 1.198E-3 6.195E-3 3.678E-2
2.540E-1
 2 77
42 int:CCDC155 CCDC155 interactions 1.229E-3 6.205E-3 3.683E-2
2.606E-1
 2 78
43 int:COL6A3 COL6A3 interactions 2.032E-3 9.574E-3
5.683E-2
4.308E-1
 1 3
44 int:MMP25 MMP25 interactions 2.032E-3 9.574E-3
5.683E-2
4.308E-1
 1 3
45 int:ADAMTS5 ADAMTS5 interactions 2.032E-3 9.574E-3
5.683E-2
4.308E-1
 1 3
46 int:CXCL6 CXCL6 interactions 2.709E-3 1.248E-2
7.411E-2
5.743E-1
 1 4
47 int:MSRB1 MSRB1 interactions 3.385E-3 1.465E-2
8.694E-2
7.176E-1
 1 5
48 int:MMP17 MMP17 interactions 3.385E-3 1.465E-2
8.694E-2
7.176E-1
 1 5
49 int:KPNA7 KPNA7 interactions 3.385E-3 1.465E-2
8.694E-2
7.176E-1
 1 5
50 int:ITGB1 ITGB1 interactions 3.519E-3 1.492E-2
8.858E-2
7.461E-1
 2 133
Show 45 more annotations

10: Cytoband [Display Chart] 12 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q22.3 11q22.3 1.079E-4 1.187E-3 3.584E-3 1.187E-3 2 45
2 2q23 2q23 6.923E-4 2.284E-3 6.898E-3 7.615E-3 1 2
3 20q11.2-q13.1 20q11.2-q13.1 6.923E-4 2.284E-3 6.898E-3 7.615E-3 1 2
4 14q11-q12 14q11-q12 1.038E-3 2.284E-3 6.898E-3 1.142E-2 1 3
5 Xp11.3-p11.23 Xp11.3-p11.23 1.038E-3 2.284E-3 6.898E-3 1.142E-2 1 3
6 16q13-q21 16q13-q21 1.384E-3 2.538E-3 7.663E-3 1.523E-2 1 4
7 7p21.2 7p21.2 3.802E-3 5.975E-3 1.804E-2 4.183E-2 1 11
8 3p25 3p25 5.871E-3 8.072E-3 2.438E-2
6.458E-2
 1 17
9 4q21 4q21 7.247E-3 8.858E-3 2.675E-2
7.972E-2
 1 21
10 22q12.3 22q12.3 1.239E-2 1.342E-2 4.053E-2
1.363E-1
 1 36
11 17q25 17q25 1.342E-2 1.342E-2 4.053E-2
1.476E-1
 1 39
Show 6 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 140 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 RYAAAKNNNNNNTTGW UNKNOWN RYAAAKNNNNNNTTGW UNKNOWN 7.720E-5 1.081E-2
5.969E-2
 1.081E-2 3 71

12: Gene Family [Display Chart] 12 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 892 Tissue inhibitor of metallopeptidases genenames.org 1.085E-13 6.507E-13 1.594E-12 6.507E-13 4 4
2 891 Matrix metallopeptidases genenames.org 2.015E-12 6.045E-12 1.481E-11 1.209E-11 5 24
3 1205 DASH family genenames.org 4.609E-3 9.217E-3 2.258E-2 2.765E-2 1 7
4 542 Endogenous ligands genenames.org 1.023E-2 1.535E-2 3.760E-2
6.140E-2
 2 237
5 483 Chemokine ligands|Endogenous ligands genenames.org 2.929E-2 3.515E-2
8.611E-2
1.757E-1
 1 45

13: Coexpression [Display Chart] 12 input genes in category / 2000 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16081686-SuppTable2 Human Lymphoma Tome05 357genes GeneSigDB 4.068E-13 8.137E-10 6.655E-9 8.137E-10 7 155
2 19795415-Table1 Mouse Lung Beisiegel09 262genes GeneSigDB 3.160E-12 3.160E-9 2.585E-8 6.321E-9 7 207
3 M5946 Genes encoding components of blood coagulation system; also up-regulated in platelets. MSigDB H: Hallmark Gene Sets (v6.0) 3.620E-11 2.414E-8 1.974E-7 7.241E-8 6 138
4 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.071E-10 5.354E-8 4.379E-7 2.142E-7 6 165
5 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v6.0) 3.425E-10 1.370E-7 1.120E-6 6.849E-7 6 200
6 M4767 Cluster 2: ECM related genes up-regulated in dermal fibroblasts within 30 min after TGFB1 [GeneID=7040] addition; reached a plateau after that. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.215E-10 1.738E-7 1.422E-6 1.043E-6 4 25
7 14982484-Table3 Human Intestine Vozenin-Brotons04 119genes GeneSigDB 1.959E-9 5.204E-7 4.256E-6 3.917E-6 5 113
8 18044827-Table2 Human Breast Bergamaschi08 278genes GeneSigDB 2.082E-9 5.204E-7 4.256E-6 4.163E-6 6 270
9 M17471 Genes up-regulated in invasive ductal carcinoma (IDC) relative to ductal carcinoma in situ (DCIS, non-invasive). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.995E-9 2.221E-6 1.817E-5 1.999E-5 6 351
10 18435859-ShorterGeneList Mouse Breast Piechocki08 558genes GeneSigDB 1.506E-8 3.012E-6 2.464E-5 3.012E-5 6 376
11 M4737 ECM related genes up-regulated early (within 30 min) in dermal fibroblasts after addition of TGFB1 [GeneID=7040]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.733E-8 3.151E-6 2.577E-5 3.466E-5 4 58
12 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.449E-8 4.081E-6 3.338E-5 4.898E-5 6 408
13 20521089-SuppTable1a Human Breast Blick10 69genes EMT up GeneSigDB 3.123E-8 4.805E-6 3.930E-5 6.247E-5 4 67
14 M7233 Genes up-regulated in T cells: control (0h) versus IL21 [GeneID=59067] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 3.461E-8 4.945E-6 4.044E-5 6.922E-5 5 200
15 16699793-Table2 Human pancreas Miyake06 72genes GeneSigDB 3.955E-8 5.273E-6 4.313E-5 7.910E-5 4 71
16 17295094-GeneList Human Breast VandenEynden07 269genes-hypoxia angiogenesis GeneSigDB 1.356E-7 1.659E-5 1.357E-4 2.712E-4 5 263
17 M1792 Protease genes up-regulated at tumor-bone interface compared to the tumor alone area. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.410E-7 1.659E-5 1.357E-4 2.820E-4 3 21
18 M5369 Genes up-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.092E-7 2.324E-5 1.901E-4 4.184E-4 5 287
19 M2271 Genes down-regulated during adipogenesis of 3T3-L1 cells (fibroblast). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.436E-7 2.564E-5 2.097E-4 4.872E-4 3 25
20 M12313 Genes up-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.979E-7 2.979E-5 2.437E-4 5.959E-4 4 117
21 16707426-SuppTable2 Human Prostate Zhang06 128genes GeneSigDB 3.525E-7 3.357E-5 2.746E-4 7.050E-4 4 122
22 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.274E-7 3.886E-5 3.178E-4 8.549E-4 4 128
23 17206280-TableS1C Mouse Breast Park07 173genes GeneSigDB 4.549E-7 3.955E-5 3.235E-4 9.097E-4 4 130
24 19038878-SuppTable3 Human Leukemia Lenz08 385genes GeneSigDB 5.510E-7 4.591E-5 3.755E-4 1.102E-3 5 349
25 15126339-Table1b Human Breast Jones04 50genes myoepithelial GeneSigDB 5.765E-7 4.612E-5 3.772E-4 1.153E-3 3 33
26 14973074-Table2 Human Stomach Meireles04 42genes GeneSigDB 6.321E-7 4.862E-5 3.976E-4 1.264E-3 3 34
27 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 1.053E-6 7.646E-5 6.254E-4 2.107E-3 5 398
28 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v6.0) 1.071E-6 7.646E-5 6.254E-4 2.141E-3 4 161
29 16495925-Table3 Human Breast Lombaerts06 43genes TGBFb GeneSigDB 1.210E-6 8.343E-5 6.823E-4 2.420E-3 3 42
30 18692832-Table1 Human Uterine Yasuo09 58genes GeneSigDB 1.706E-6 1.138E-4 9.303E-4 3.413E-3 3 47
31 15452378-Table2 Human Liver Chiba04 52genes GeneSigDB 2.061E-6 1.288E-4 1.053E-3 4.121E-3 3 50
32 16479545-Table2 Mouse Lung not cancer Kahnert06 70genes GeneSigDB 2.061E-6 1.288E-4 1.053E-3 4.121E-3 3 50
33 M10372 Cancer related genes up-regulated in any of four hepatoma cell lines following 24 h treatment with TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.322E-6 1.407E-4 1.151E-3 4.644E-3 3 52
34 M6892 Genes down-regulated in CD4 [GeneID=920] T cells with in vivo expansion: IL6 [GeneID=3569] versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.540E-6 1.411E-4 1.154E-3 5.081E-3 4 200
35 M5921 Genes encoding components of the complement system, which is part of the innate immune system. MSigDB H: Hallmark Gene Sets (v6.0) 2.540E-6 1.411E-4 1.154E-3 5.081E-3 4 200
36 M6887 Genes down-regulated in monocytes after HCMV infection: BAY 11-7082 [PubChem=5353431] versus Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v6.0) 2.540E-6 1.411E-4 1.154E-3 5.081E-3 4 200
37 M19948 Genes whose DNA was methylated both in primary tumors and across a panel of cancer cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.909E-6 1.573E-4 1.286E-3 5.819E-3 3 56
38 18394172-S3GeneList Mouse Breast Wright08 339genes GeneSigDB 3.386E-6 1.782E-4 1.457E-3 6.771E-3 4 215
39 14676830-Table4 Human HeadandNeck Cromer04 64genes GeneSigDB 3.772E-6 1.934E-4 1.582E-3 7.543E-3 3 61
40 14583454-TableS1 Human Brain Godard03 239genes GeneSigDB 4.127E-6 2.029E-4 1.659E-3 8.253E-3 4 226
41 M178 Tumorigenesis markers of head and neck squamous cell carcinoma (HNSCC): up-regulated in the 'early' tumors vs normal samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.159E-6 2.029E-4 1.659E-3 8.318E-3 3 63
42 M2572 Invasiveness signature resulting from cancer cell/microenvironment interaction. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.363E-6 2.077E-4 1.699E-3 8.725E-3 3 64
43 18698033-tableS1-PLAU Human Breast Desmedt08 68genes PLAU Module GeneSigDB 5.241E-6 2.438E-4 1.994E-3 1.048E-2 3 68
44 17571080-SuppTable2c Human Leukemia Sun07 90genes GeneSigDB 6.230E-6 2.832E-4 2.316E-3 1.246E-2 3 72
45 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.185E-6 3.189E-4 2.608E-3 1.437E-2 4 260
46 M17951 Top 100 probe sets contrubuting to the positive side of the 1st principal component; predominantly associated with spindle cell and pleomorphic sarcoma samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.335E-6 3.189E-4 2.608E-3 1.467E-2 3 76
47 M3495 Angiogenic and metastatic genes changed in RKO cells (colorectal cancer) upon perturbation of key components of AKT pathway. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.107E-5 4.474E-4 3.659E-3 2.214E-2 2 10
48 M1162 STAT1 [GeneID=6772] targets in hematopoetic signaling. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.107E-5 4.474E-4 3.659E-3 2.214E-2 2 10
49 M1875 Cytokines, growth factors, and secreted proteins that show increased expression on a protein array of samples from aged TERC [GeneID=7012] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.107E-5 4.474E-4 3.659E-3 2.214E-2 2 10
50 16509772-TableS1 Human StemCell Coller06 136genes GeneSigDB 1.141E-5 4.474E-4 3.659E-3 2.282E-2 3 88
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 12 input genes in category / 1693 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/1 TCGA-Colorectal 2.684E-12 4.544E-9 3.640E-8 4.544E-9 7 191
2 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.138E-11 9.632E-9 7.717E-8 1.926E-8 8 438
3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/3 TCGA-Stomach 1.948E-10 1.099E-7 8.808E-7 3.298E-7 6 172
4 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 1.012E-9 3.996E-7 3.201E-6 1.714E-6 7 445
5 GSM777055 500 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.182E-9 3.996E-7 3.201E-6 2.001E-6 7 455
6 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 1.416E-9 3.996E-7 3.201E-6 2.397E-6 7 467
7 Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma1-C8-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma1-C8-KC7 Top 200 Genes 8.279E-9 2.002E-6 1.604E-5 1.402E-5 6 321
8 GSM854258 100 Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4 Immgen.org, GSE15907 3.064E-8 6.048E-6 4.845E-5 5.187E-5 4 63
9 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/stromal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Mammary Gland/stromal cell Tabula Muris Consortium 3.388E-8 6.048E-6 4.845E-5 5.736E-5 5 188
10 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Limb Muscle/mesenchymal stem cell Tabula Muris Consortium 3.572E-8 6.048E-6 4.845E-5 6.048E-5 5 190
11 GSM854262 100 Myeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7 Immgen.org, GSE15907 6.230E-8 9.063E-6 7.261E-5 1.055E-4 4 75
12 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 6.424E-8 9.063E-6 7.261E-5 1.088E-4 6 453
13 JC fibro 1000 K1 JC fibro top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 7.405E-8 9.643E-6 7.726E-5 1.254E-4 6 464
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter F-U/Ureter Normal RCC F-U/Ureter Normal RCC F21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter F-U/Ureter Normal RCC F-U/Ureter Normal RCC F21 Adult, Development, and Cancer types 2.337E-7 2.826E-5 2.264E-4 3.956E-4 4 104
15 ratio ECTO vs SC 500 K5 ratio induced-Ectoderm vs StemCell top-relative-expression-ranked 500 k-means-cluster#5 PCBC 4.601E-7 5.192E-5 4.160E-4 7.789E-4 3 29
16 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 9.146E-7 8.957E-5 7.176E-4 1.548E-3 5 365
17 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes 9.146E-7 8.957E-5 7.176E-4 1.548E-3 5 365
18 GSM854258 500 Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4 Immgen.org, GSE15907 9.523E-7 8.957E-5 7.176E-4 1.612E-3 5 368
19 GSM854262 500 Myeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7 Immgen.org, GSE15907 1.130E-6 1.007E-4 8.066E-4 1.913E-3 5 381
20 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Tubulolobular Carcinoma/4 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Tubulolobular Carcinoma/4 TCGA-Breast 1.674E-6 1.417E-4 1.135E-3 2.834E-3 4 170
21 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 2.267E-6 1.677E-4 1.344E-3 3.838E-3 5 439
22 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 2.559E-6 1.677E-4 1.344E-3 4.333E-3 5 450
23 GSM538280 500 Myeloid Cells, DC.LC.Sk, MHCII+ CD11b+ CD45+, Skin, avg-2 Immgen.org, GSE15907 2.615E-6 1.677E-4 1.344E-3 4.428E-3 5 452
24 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic stellate cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic stellate cell Tabula Muris Consortium 2.717E-6 1.677E-4 1.344E-3 4.600E-3 4 192
25 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Bladder/bladder cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Bladder/bladder cell Tabula Muris Consortium 2.717E-6 1.677E-4 1.344E-3 4.600E-3 4 192
26 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/fibroblast Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/fibroblast Tabula Muris Consortium 2.717E-6 1.677E-4 1.344E-3 4.600E-3 4 192
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Adult, Development, and Cancer types 2.774E-6 1.677E-4 1.344E-3 4.696E-3 4 193
28 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/stromal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/stromal cell Tabula Muris Consortium 2.774E-6 1.677E-4 1.344E-3 4.696E-3 4 193
29 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/mesenchymal cell Tabula Muris Consortium 2.890E-6 1.687E-4 1.352E-3 4.893E-3 4 195
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal RCC U U/Ureter Normal RCC U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal RCC U U/Ureter Normal RCC U21 Adult, Development, and Cancer types 3.071E-6 1.733E-4 1.388E-3 5.199E-3 4 198
31 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb.Gja1 Astrocyte.astrocytes.Rorb.Gja1 Top 200 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb.Gja1 Astrocyte.astrocytes.Rorb.Gja1 Top 200 BrainMap 8.494E-6 4.494E-4 3.600E-3 1.438E-2 4 256
32 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb.Gja1 Astrocyte.astrocytes.Rorb.Gja1 Subtype Astrocyte.astrocytes.Rorb.Gja1.Myoc Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.Rorb.Gja1 Astrocyte.astrocytes.Rorb.Gja1 Subtype Astrocyte.astrocytes.Rorb.Gja1.Myoc Top 200 Genes BrainMap 8.494E-6 4.494E-4 3.600E-3 1.438E-2 4 256
33 Lungmap Mouse Lung PND3 MatrixFB Subtype MyoFB-A(2) Lungmap Mouse Lung PND3 MatrixFB Subtype MyoFB-A(2) Lungmap CCHMC 8.759E-6 4.494E-4 3.600E-3 1.483E-2 4 258
34 gudmap dev gonad e13.5 F VascAssocMesenchStromOvary MafB k2 1000 dev gonad e13.5 F VascAssocMesenchStromOvary MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.881E-6 4.920E-4 3.942E-3 1.673E-2 4 266
35 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C9-KC4 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C9-KC4 Top 200 Genes 1.127E-5 5.449E-4 4.366E-3 1.907E-2 4 275
36 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma3-C2-KC1 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma3-C2-KC1 Top 200 Genes 1.209E-5 5.688E-4 4.557E-3 2.048E-2 4 280
37 GSM777055 100 Stromal Cells, FRC.SLN, gp38+ CD31- CD140a+, Lymph Node, avg-4 Immgen.org, GSE15907 1.266E-5 5.793E-4 4.641E-3 2.143E-2 3 86
38 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-B(1) Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-B(1) Lungmap CCHMC 1.650E-5 7.351E-4 5.890E-3 2.794E-2 4 303
39 GSM777046 100 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 1.818E-5 7.890E-4 6.322E-3 3.077E-2 3 97
40 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Subtype Dcn.Dcn Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Tip Subtype Dcn.Dcn Top 200 Genes 2.684E-5 1.108E-3 8.879E-3 4.544E-2 4 343
41 BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Subtype Endothelial Tip. .Dcn.Dcn Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Tip. .Dcn Endothelial Tip. .Dcn Subtype Endothelial Tip. .Dcn.Dcn Top 200 Genes BrainMap 2.684E-5 1.108E-3 8.879E-3 4.544E-2 4 343
42 endometrium endometrium Human Protein Atlas 3.027E-5 1.169E-3 9.363E-3
5.125E-2
 3 115
43 gudmap dev gonad e11.5 F GonadVasMes Flk k3 1000 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.071E-5 1.169E-3 9.363E-3
5.199E-2
 4 355
44 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma3-C2-KC3 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma3-C2-KC3 Top 200 Genes 3.071E-5 1.169E-3 9.363E-3
5.199E-2
 4 355
45 ratio EB vs SC 500 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 k-means-cluster#5 PCBC 3.106E-5 1.169E-3 9.363E-3
5.259E-2
 3 116
46 Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C8-KC2 Top 200 Genes Kidney10XCellRanger Six2KI E14 Stroma Stroma Subtype E14-Six2KI-Stroma2-C8-KC2 Top 200 Genes 3.208E-5 1.181E-3 9.460E-3
5.431E-2
 4 359
47 GSM854276 500 Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4 Immgen.org, GSE15907 3.386E-5 1.220E-3 9.773E-3
5.733E-2
 4 364
48 Glioblastoma Single Cell Merged Vascular Subtype Vascular-Vascular.12 Top 200 Genes Glioblastoma Single Cell Merged Vascular Subtype Vascular-Vascular.12 Top 200 Genes 3.572E-5 1.260E-3 1.009E-2
6.047E-2
 4 369
49 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Oligodendrocyte/Oligodendrocyte/Oligodendrocyte/Tnr BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Oligodendrocyte/Oligodendrocyte/Oligodendrocyte/Tnr BrainMap 3.791E-5 1.263E-3 1.012E-2
6.419E-2
 3 124
50 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes 3.804E-5 1.263E-3 1.012E-2
6.440E-2
 4 375
Show 45 more annotations

15: Computational [Display Chart] 12 input genes in category / 82 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19072 MODULE 562 MMPs. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.936E-20 3.227E-18 1.611E-17 3.227E-18 8 21
2 M13268 MODULE 210 Genes in the cancer module 210. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.428E-13 9.953E-12 4.967E-11 1.991E-11 6 28
3 M17376 MODULE 107 Genes in the cancer module 107. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.095E-12 2.993E-11 1.493E-10 8.978E-11 7 79
4 M15716 MODULE 209 Catabolic peptidases. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.591E-12 5.312E-11 2.651E-10 2.125E-10 7 89
5 M10041 MODULE 172 Genes in the cancer module 172. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.468E-12 6.595E-11 3.291E-10 3.664E-10 7 96
6 M11185 MODULE 128 Genes in the cancer module 128. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.182E-12 6.595E-11 3.291E-10 4.249E-10 7 98
7 M8286 MODULE 79 Genes in the cancer module 79. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.991E-12 6.595E-11 3.291E-10 4.912E-10 7 100
8 M2944 MODULE 170 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.434E-12 6.595E-11 3.291E-10 5.276E-10 7 101
9 M15032 MODULE 211 Genes in the cancer module 211. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.848E-10 3.506E-9 1.749E-8 3.155E-8 4 11
10 M19173 MODULE 280 Metal ion (zinc) binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.115E-9 9.141E-9 4.561E-8 9.141E-8 5 45
11 M5502 MODULE 371 Genes in the cancer module 371. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.727E-8 1.287E-7 6.423E-7 1.416E-6 4 26
12 M4515 MODULE 324 Metal / Ca ion binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.785E-7 1.903E-6 9.498E-6 2.284E-5 5 133
13 M6257 MODULE 164 Enzyme inhibitors (esp serine proteases). MSigDb: C4 - CM: Cancer Modules (v6.0) 4.520E-5 2.851E-4 1.423E-3 3.706E-3 3 61
14 M10615 MODULE 255 Genes in the cancer module 255. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.505E-3 8.814E-3 4.398E-2
1.234E-1
 4 452
15 M753 MODULE 179 Blood cells and cancer expression cancer. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.740E-3 9.510E-3 4.745E-2
1.426E-1
 4 470
16 M16395 MODULE 47 ECM and collagens. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.105E-3 1.079E-2
5.385E-2
1.726E-1
 3 225
17 M13472 MODULE 99 Genes in the cancer module 99. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.787E-3 3.756E-2
1.874E-1
6.385E-1
 3 358
18 M3090 MODULE 532 Blood cells and cancer expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.123E-2 4.878E-2
2.434E-1
9.206E-1
 3 409
19 M12108 MODULE 118 cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.130E-2 4.878E-2
2.434E-1
9.268E-1
 3 410
20 M4403 MODULE 459 Genes in the cancer module 459. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.311E-2 4.942E-2
2.466E-1
1.000E0
 3 433
21 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.319E-2 4.942E-2
2.466E-1
1.000E0
 3 434
22 M809 MODULE 378 Genes in the cancer module 378. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.344E-2 4.942E-2
2.466E-1
1.000E0
 3 437
23 M11172 MODULE 317 Genes in the cancer module 317. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.386E-2 4.942E-2
2.466E-1
1.000E0
 3 442
Show 18 more annotations

16: MicroRNA [Display Chart] 12 input genes in category / 262 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-143-3p:Functional MTI Functional MTI miRTarbase 4.690E-8 1.229E-5 7.553E-5 1.229E-5 4 228
2 hsa-miR-891a:PITA hsa-miR-891a:PITA TOP PITA 8.202E-6 1.024E-3 6.298E-3 2.149E-3 2 26
3 hsa-miR-451a:Functional MTI Functional MTI miRTarbase 1.173E-5 1.024E-3 6.298E-3 3.073E-3 2 31
4 hsa-miR-891a:mirSVR lowEffct hsa-miR-891a:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.165E-5 1.258E-3 7.736E-3 5.671E-3 3 338
5 hsa-miR-9-5p:Functional MTI Functional MTI miRTarbase 2.401E-5 1.258E-3 7.736E-3 6.292E-3 3 350
6 hsa-miR-203a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.787E-5 2.963E-3 1.822E-2 1.778E-2 2 74
7 hsa-miR-133b:Functional MTI Functional MTI miRTarbase 8.751E-5 3.275E-3 2.014E-2 2.293E-2 2 84
8 hsa-miR-146b-3p:PITA hsa-miR-146b-3p:PITA TOP PITA 1.641E-4 5.374E-3 3.303E-2 4.299E-2 2 115
9 hsa-miR-302a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.001E-4 5.824E-3 3.580E-2
5.241E-2
 2 127
10 hsa-miR-338-3p:Functional MTI Functional MTI miRTarbase 2.500E-4 6.549E-3 4.026E-2
6.549E-2
 2 142
11 hsa-miR-720:Functional MTI Functional MTI miRTarbase 3.322E-4 7.380E-3 4.537E-2
8.704E-2
 1 2
12 hsa-miR-491-5p:Functional MTI Functional MTI miRTarbase 3.662E-4 7.380E-3 4.537E-2
9.594E-2
 2 172
13 hsa-miR-524-5p:Functional MTI Functional MTI miRTarbase 3.662E-4 7.380E-3 4.537E-2
9.594E-2
 2 172
14 hsa-miR-132-3p:Functional MTI Functional MTI miRTarbase 8.002E-4 1.464E-2
8.998E-2
2.097E-1
 2 255
15 hsa-miR-29b-3p:Functional MTI Functional MTI miRTarbase 8.379E-4 1.464E-2
8.998E-2
2.195E-1
 2 261
16 hsa-miR-221-3p:Functional MTI Functional MTI miRTarbase 1.651E-3 2.283E-2
1.404E-1
4.326E-1
 2 368
17 hsa-miR-337-5p:mirSVR lowEffct hsa-miR-337-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.651E-3 2.283E-2
1.404E-1
4.326E-1
 2 368
18 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 2.052E-3 2.283E-2
1.404E-1
5.377E-1
 2 411
19 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 2.151E-3 2.283E-2
1.404E-1
5.637E-1
 2 421
20 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 2.151E-3 2.283E-2
1.404E-1
5.637E-1
 2 421
21 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 2.151E-3 2.283E-2
1.404E-1
5.637E-1
 2 421
22 hsa-miR-125b-5p:Functional MTI Functional MTI miRTarbase 2.253E-3 2.283E-2
1.404E-1
5.903E-1
 2 431
23 hsa-miR-371-3p:mirSVR lowEffct hsa-miR-371-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.452E-3 2.283E-2
1.404E-1
6.424E-1
 2 450
24 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 2.463E-3 2.283E-2
1.404E-1
6.452E-1
 2 451
25 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 2.538E-3 2.283E-2
1.404E-1
6.650E-1
 2 458
26 hsa-miR-146b-3p:mirSVR highEffct hsa-miR-146b-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.604E-3 2.283E-2
1.404E-1
6.821E-1
 2 464
27 TGAATGT,MIR-181A:MSigDB TGAATGT,MIR-181A:MSigDB MSigDB 2.615E-3 2.283E-2
1.404E-1
6.850E-1
 2 465
28 TGAATGT,MIR-181C:MSigDB TGAATGT,MIR-181C:MSigDB MSigDB 2.615E-3 2.283E-2
1.404E-1
6.850E-1
 2 465
29 TGAATGT,MIR-181B:MSigDB TGAATGT,MIR-181B:MSigDB MSigDB 2.615E-3 2.283E-2
1.404E-1
6.850E-1
 2 465
30 TGAATGT,MIR-181D:MSigDB TGAATGT,MIR-181D:MSigDB MSigDB 2.615E-3 2.283E-2
1.404E-1
6.850E-1
 2 465
31 hsa-miR-425*:mirSVR lowEffct hsa-miR-425*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.978E-3 2.517E-2
1.547E-1
7.803E-1
 2 497
32 hsa-miR-6743-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.649E-3 2.987E-2
1.836E-1
9.559E-1
 1 22
33 AGTCTAG,MIR-151:MSigDB AGTCTAG,MIR-151:MSigDB MSigDB 3.980E-3 3.067E-2
1.885E-1
1.000E0
 1 24
34 hsa-miR-887:PITA hsa-miR-887:PITA TOP PITA 3.980E-3 3.067E-2
1.885E-1
1.000E0
 1 24
35 hsa-miR-127-3p:Functional MTI Functional MTI miRTarbase 4.807E-3 3.598E-2
2.212E-1
1.000E0
 1 29
Show 30 more annotations

17: Drug [Display Chart] 12 input genes in category / 5528 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000003890 AC1L1GXT Stitch 5.183E-21 2.865E-17 2.634E-16 2.865E-17 9 74
2 CID000003498 AC1L1G2K Stitch 1.724E-20 4.766E-17 4.382E-16 9.531E-17 9 84
3 CID000119031 marimastat Stitch 1.975E-18 3.640E-15 3.347E-14 1.092E-14 8 68
4 CID005288446 AC1NRBJE Stitch 4.356E-18 6.020E-15 5.535E-14 2.408E-14 9 152
5 CID000002299 AC1L1DD6 Stitch 1.963E-17 2.103E-14 1.933E-13 1.085E-13 9 179
6 CID006441636 latanoprost acid Stitch 2.282E-17 2.103E-14 1.933E-13 1.262E-13 7 40
7 ctd:C581572 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea CTD 1.220E-16 9.637E-14 8.861E-13 6.746E-13 7 50
8 CID004283518 anti-TIMP-4 Stitch 3.210E-16 2.218E-13 2.040E-12 1.775E-12 5 7
9 CID000001318 1,10-phenanthroline Stitch 7.599E-16 4.668E-13 4.292E-12 4.201E-12 9 267
10 ctd:C097658 CGS 27023A CTD 1.925E-15 1.064E-12 9.785E-12 1.064E-11 5 9
11 CID009906466 A0395 Stitch 2.413E-15 1.213E-12 1.115E-11 1.334E-11 7 75
12 CID000197672 BB-87 Stitch 3.849E-15 1.773E-12 1.630E-11 2.128E-11 5 10
13 CID000466151 prinomastat Stitch 5.161E-15 2.195E-12 2.018E-11 2.853E-11 6 33
14 CID005464587 D3273 Stitch 1.240E-14 4.896E-12 4.502E-11 6.855E-11 7 94
15 ctd:C003466 thymoquinone CTD 7.376E-14 2.718E-11 2.500E-10 4.078E-10 6 50
16 ctd:D012460 Sulfasalazine CTD 2.156E-13 7.451E-11 6.851E-10 1.192E-9 7 140
17 ctd:C433788 lipopolysaccharide, E. coli O26-B6 CTD 2.769E-13 9.004E-11 8.279E-10 1.531E-9 7 145
18 CID000026248 diacerein Stitch 3.145E-13 9.658E-11 8.880E-10 1.738E-9 6 63
19 ctd:D017035 Pravastatin CTD 4.615E-13 1.343E-10 1.235E-9 2.551E-9 6 67
20 ctd:C117155 tetracycline CMT-3 CTD 6.469E-13 1.775E-10 1.632E-9 3.576E-9 5 24
21 ctd:C432165 pyrazolanthrone CTD 6.743E-13 1.775E-10 1.632E-9 3.727E-9 8 322
22 CID000181572 anti-TIMP-2 Stitch 1.527E-12 3.836E-10 3.527E-9 8.440E-9 4 7
23 CID006102706 AC1O0UVD Stitch 1.614E-12 3.879E-10 3.566E-9 8.921E-9 6 82
24 CID000195836 Ataa Stitch 2.166E-12 4.988E-10 4.587E-9 1.197E-8 5 30
25 CID000124934 Vgvapg Stitch 2.581E-12 5.708E-10 5.248E-9 1.427E-8 5 31
26 ctd:C012037 solasodine CTD 3.053E-12 5.844E-10 5.373E-9 1.688E-8 4 8
27 DB00786 Marimastat Drug Bank 3.053E-12 5.844E-10 5.373E-9 1.688E-8 4 8
28 CID006449115 malolactomycin D Stitch 3.059E-12 5.844E-10 5.373E-9 1.691E-8 5 32
29 CID000104904 ecgonine methyl ester Stitch 3.066E-12 5.844E-10 5.373E-9 1.695E-8 6 91
30 CID005327336 sulfonamide analog 1 Stitch 4.230E-12 7.794E-10 7.166E-9 2.338E-8 7 213
31 ctd:C002070 betulinic acid CTD 4.927E-12 8.786E-10 8.079E-9 2.724E-8 5 35
32 ctd:C113580 U 0126 CTD 8.855E-12 1.530E-9 1.407E-8 4.895E-8 8 444
33 CID000003499 Go6983 Stitch 9.974E-12 1.671E-9 1.536E-8 5.514E-8 5 40
34 CID000444708 N-methylmesoporphyrin Stitch 1.289E-11 2.095E-9 1.927E-8 7.124E-8 5 42
35 ctd:D061965 Matrix Metalloproteinase Inhibitors CTD 1.438E-11 2.208E-9 2.030E-8 7.949E-8 4 11
36 ctd:C573672 VI-14 flavonoid CTD 1.438E-11 2.208E-9 2.030E-8 7.949E-8 4 11
37 ctd:C000873 methylprednisolone acetate CTD 2.156E-11 3.222E-9 2.962E-8 1.192E-7 4 12
38 ctd:C067584 formosanin C CTD 3.114E-11 4.414E-9 4.058E-8 1.721E-7 4 13
39 CID000151134 Phe-glu Stitch 3.114E-11 4.414E-9 4.058E-8 1.721E-7 4 13
40 CID002723800 safranin Stitch 3.203E-11 4.427E-9 4.071E-8 1.771E-7 5 50
41 CID000000604 gluconate Stitch 3.450E-11 4.652E-9 4.277E-8 1.907E-7 7 287
42 CID000040632 pirfenidone Stitch 3.910E-11 5.146E-9 4.732E-8 2.161E-7 6 138
43 ctd:C482289 Ageladine A CTD 4.358E-11 5.603E-9 5.151E-8 2.409E-7 4 14
44 ctd:D005944 Glucosamine CTD 6.338E-11 7.963E-9 7.322E-8 3.504E-7 7 313
45 ctd:C532757 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide CTD 1.108E-10 1.331E-8 1.224E-7 6.124E-7 3 3
46 ctd:C495612 CP-471,358 CTD 1.108E-10 1.331E-8 1.224E-7 6.124E-7 3 3
47 ctd:D019808 Losartan CTD 1.156E-10 1.360E-8 1.250E-7 6.392E-7 6 165
48 CID000446504 MMI270 Stitch 1.331E-10 1.533E-8 1.409E-7 7.356E-7 4 18
49 ctd:D015054 Zymosan CTD 1.487E-10 1.677E-8 1.542E-7 8.219E-7 6 172
50 CID000177347 AC1L42OX Stitch 2.106E-10 2.328E-8 2.141E-7 1.164E-6 4 20
Show 45 more annotations

18: Disease [Display Chart] 12 input genes in category / 1207 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0155094 Corneal pannus DisGeNET BeFree 2.042E-19 2.465E-16 1.892E-15 2.465E-16 8 38
2 C0031099 Periodontitis DisGeNET Curated 2.312E-13 1.368E-10 1.050E-9 2.790E-10 8 201
3 C0856742 post mi DisGeNET BeFree 3.401E-13 1.368E-10 1.050E-9 4.105E-10 6 46
4 C3258293 Valvular disease DisGeNET BeFree 8.613E-13 2.599E-10 1.994E-9 1.040E-9 4 5
5 C0333297 Chronic ulcer DisGeNET BeFree 1.722E-12 3.679E-10 2.823E-9 2.078E-9 5 21
6 C0162871 Aortic Aneurysm, Abdominal DisGeNET Curated 2.026E-12 3.679E-10 2.823E-9 2.445E-9 8 263
7 C0266929 Chronic Periodontitis DisGeNET Curated 2.359E-12 3.679E-10 2.823E-9 2.848E-9 7 140
8 C0878693 Conjunctivochalasis DisGeNET BeFree 2.583E-12 3.679E-10 2.823E-9 3.118E-9 4 6
9 C0027626 Neoplasm Invasiveness DisGeNET Curated 2.744E-12 3.679E-10 2.823E-9 3.312E-9 7 143
10 C0002940 Aneurysm DisGeNET Curated 3.503E-12 4.228E-10 3.244E-9 4.228E-9 7 148
11 C0079474 Hallopeau-Siemens Disease DisGeNET Curated 1.432E-11 1.572E-9 1.206E-8 1.729E-8 5 31
12 C0041582 Ulcer DisGeNET Curated 1.837E-11 1.848E-9 1.418E-8 2.217E-8 7 187
13 C0275904 Tuberculosis, Central Nervous System DisGeNET BeFree 2.167E-11 2.012E-9 1.544E-8 2.616E-8 4 9
14 C0879615 Stromal Neoplasm DisGeNET BeFree 2.386E-11 2.057E-9 1.578E-8 2.879E-8 6 91
15 C0029172 Oral Submucous Fibrosis DisGeNET Curated 4.840E-11 3.895E-9 2.989E-8 5.842E-8 5 39
16 C1868193 PNEUMOTHORAX, PRIMARY SPONTANEOUS DisGeNET Curated 8.504E-11 6.415E-9 4.923E-8 1.026E-7 4 12
17 C0239946 Fibrosis, Liver DisGeNET Curated 1.119E-10 7.945E-9 6.096E-8 1.351E-7 8 434
18 C0333307 Superficial ulcer DisGeNET BeFree 2.773E-10 1.859E-8 1.427E-7 3.346E-7 6 136
19 C0024796 Marfan Syndrome DisGeNET Curated 3.191E-10 2.027E-8 1.556E-7 3.852E-7 5 56
20 C0079293 Epidermolysis Bullosa Acquisita DisGeNET BeFree 4.081E-10 2.463E-8 1.890E-7 4.925E-7 4 17
21 C0152164 Cyclical vomiting syndrome (disorder) DisGeNET BeFree 1.240E-9 7.130E-8 5.471E-7 1.497E-6 3 4
22 C1511789 Desmoplastic DisGeNET BeFree 1.867E-9 1.025E-7 7.862E-7 2.254E-6 5 79
23 C0158266 Intervertebral Disc Degeneration DisGeNET Curated 2.712E-9 1.423E-7 1.092E-6 3.273E-6 5 85
24 C0158252 Intervertebral disc disorder DisGeNET Curated 4.675E-9 2.170E-7 1.665E-6 5.642E-6 4 30
25 C2931384 Moyamoya disease 1 DisGeNET Curated 4.675E-9 2.170E-7 1.665E-6 5.642E-6 4 30
26 C1719495 Aggressive periodontitis, generalized DisGeNET BeFree 4.675E-9 2.170E-7 1.665E-6 5.642E-6 4 30
27 C0278996 Cancer of Head and Neck DisGeNET Curated 5.840E-9 2.611E-7 2.003E-6 7.049E-6 7 426
28 C0004238 Atrial Fibrillation DisGeNET Curated 6.942E-9 2.902E-7 2.227E-6 8.379E-6 6 232
29 C0026654 Moyamoya Disease DisGeNET Curated 6.972E-9 2.902E-7 2.227E-6 8.415E-6 4 33
30 C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 1.334E-8 5.367E-7 4.119E-6 1.610E-5 7 480
31 C0022572 keratoacanthoma DisGeNET BeFree 1.553E-8 6.046E-7 4.639E-6 1.874E-5 4 40
32 C0340643 Dissection of aorta DisGeNET Curated 1.900E-8 6.990E-7 5.364E-6 2.294E-5 4 42
33 C0026691 Mucocutaneous Lymph Node Syndrome DisGeNET Curated 1.911E-8 6.990E-7 5.364E-6 2.307E-5 5 125
34 C0001342 Acute periodontitis DisGeNET BeFree 2.526E-8 8.713E-7 6.686E-6 3.049E-5 4 45
35 C0006663 Calcinosis DisGeNET Curated 2.526E-8 8.713E-7 6.686E-6 3.049E-5 4 45
36 C1850938 FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY, OF SORSBY DisGeNET Curated 2.600E-8 8.716E-7 6.688E-6 3.138E-5 3 9
37 C0279628 Adenocarcinoma Of Esophagus DisGeNET Curated 2.688E-8 8.769E-7 6.729E-6 3.245E-5 6 291
38 C1368683 Epithelioma DisGeNET BeFree 3.097E-8 9.837E-7 7.548E-6 3.738E-5 6 298
39 C0010495 Cutis Laxa DisGeNET Curated 4.227E-8 1.308E-6 1.004E-5 5.103E-5 4 51
40 C1334274 Invasive Carcinoma DisGeNET BeFree 5.451E-8 1.645E-6 1.262E-5 6.580E-5 5 154
41 C0345967 Malignant mesothelioma DisGeNET Curated 5.784E-8 1.703E-6 1.307E-5 6.981E-5 6 331
42 C0242383 Age related macular degeneration DisGeNET Curated 6.322E-8 1.817E-6 1.394E-5 7.631E-5 6 336
43 C0024449 Mycetoma DisGeNET BeFree 6.800E-8 1.865E-6 1.431E-5 8.207E-5 3 12
44 C1568363 Tendinosis DisGeNET BeFree 6.800E-8 1.865E-6 1.431E-5 8.207E-5 3 12
45 C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 7.919E-8 2.124E-6 1.630E-5 9.558E-5 6 349
46 C0206638 Giant Cell Tumor of Bone DisGeNET Curated 8.220E-8 2.157E-6 1.655E-5 9.921E-5 4 60
47 C0543822 Atherosclerotic occlusive disease DisGeNET BeFree 8.836E-8 2.269E-6 1.741E-5 1.067E-4 3 13
48 C0265110 Cerebral Vasospasm DisGeNET BeFree 1.124E-7 2.827E-6 2.169E-5 1.357E-4 3 14
49 C0034069 Pulmonary Fibrosis DisGeNET Curated 1.212E-7 2.986E-6 2.291E-5 1.463E-4 6 375
50 C0206677 Adenomatous Polyps DisGeNET Curated 1.368E-7 3.303E-6 2.535E-5 1.652E-4 4 68
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