Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc188_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 21 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0097642 calcitonin family receptor activity 1.247E-13 2.619E-12 9.546E-12 2.619E-12 4 5
2 GO:0004948 calcitonin receptor activity 7.757E-11 8.145E-10 2.969E-9 1.629E-9 3 3
3 GO:0008565 protein transporter activity 5.205E-10 3.643E-9 1.328E-8 1.093E-8 5 101
4 GO:0008528 G protein-coupled peptide receptor activity 2.021E-9 9.510E-9 3.467E-8 4.245E-8 5 132
5 GO:0001653 peptide receptor activity 2.264E-9 9.510E-9 3.467E-8 4.755E-8 5 135
6 GO:0001605 adrenomedullin receptor activity 2.068E-7 7.237E-7 2.638E-6 4.342E-6 2 2
7 GO:0015026 coreceptor activity 8.822E-7 2.646E-6 9.647E-6 1.853E-5 3 42
8 GO:0017046 peptide hormone binding 2.025E-4 5.316E-4 1.938E-3 4.253E-3 2 45
9 GO:0042277 peptide binding 2.571E-4 5.998E-4 2.187E-3 5.399E-3 3 278
10 GO:0033218 amide binding 3.508E-4 7.234E-4 2.637E-3 7.366E-3 3 309
11 GO:0031700 adrenomedullin receptor binding 4.823E-4 7.234E-4 2.637E-3 1.013E-2 1 1
12 GO:0097644 calcitonin family binding 4.823E-4 7.234E-4 2.637E-3 1.013E-2 1 1
13 GO:0015055 secretin receptor activity 4.823E-4 7.234E-4 2.637E-3 1.013E-2 1 1
14 GO:0032841 calcitonin binding 4.823E-4 7.234E-4 2.637E-3 1.013E-2 1 1
15 GO:0042562 hormone binding 6.895E-4 9.653E-4 3.519E-3 1.448E-2 2 83
16 GO:0001635 calcitonin gene-related peptide receptor activity 9.644E-4 1.266E-3 4.614E-3 2.025E-2 1 2
17 GO:0004967 glucagon receptor activity 1.446E-3 1.687E-3 6.151E-3 3.037E-2 1 3
18 GO:0031716 calcitonin receptor binding 1.446E-3 1.687E-3 6.151E-3 3.037E-2 1 3
19 GO:0001664 G protein-coupled receptor binding 7.327E-3 8.098E-3 2.952E-2
1.539E-1
 2 276
Show 14 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 288 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031623 receptor internalization 8.336E-13 2.401E-10 1.498E-9 2.401E-10 6 89
2 GO:1900373 positive regulation of purine nucleotide biosynthetic process 3.063E-12 2.941E-10 1.836E-9 8.823E-10 6 110
3 GO:0030810 positive regulation of nucleotide biosynthetic process 3.063E-12 2.941E-10 1.836E-9 8.823E-10 6 110
4 GO:0006171 cAMP biosynthetic process 7.376E-12 5.311E-10 3.315E-9 2.124E-9 6 127
5 GO:0045981 positive regulation of nucleotide metabolic process 1.395E-11 6.698E-10 4.181E-9 4.019E-9 6 141
6 GO:1900544 positive regulation of purine nucleotide metabolic process 1.395E-11 6.698E-10 4.181E-9 4.019E-9 6 141
7 GO:1900371 regulation of purine nucleotide biosynthetic process 2.033E-11 7.622E-10 4.758E-9 5.856E-9 6 150
8 GO:0030808 regulation of nucleotide biosynthetic process 2.117E-11 7.622E-10 4.758E-9 6.098E-9 6 151
9 GO:0052652 cyclic purine nucleotide metabolic process 2.581E-11 7.728E-10 4.824E-9 7.433E-9 6 156
10 GO:0009190 cyclic nucleotide biosynthetic process 2.683E-11 7.728E-10 4.824E-9 7.728E-9 6 157
11 GO:0046058 cAMP metabolic process 3.126E-11 8.185E-10 5.109E-9 9.004E-9 6 161
12 GO:0043112 receptor metabolic process 3.629E-11 8.709E-10 5.436E-9 1.045E-8 6 165
13 GO:0009187 cyclic nucleotide metabolic process 1.392E-10 3.083E-9 1.925E-8 4.008E-8 6 206
14 GO:1900542 regulation of purine nucleotide metabolic process 2.502E-10 5.146E-9 3.212E-8 7.205E-8 6 227
15 GO:0006140 regulation of nucleotide metabolic process 3.083E-10 5.920E-9 3.695E-8 8.879E-8 6 235
16 GO:0009152 purine ribonucleotide biosynthetic process 5.045E-10 9.080E-9 5.668E-8 1.453E-7 6 255
17 GO:0006164 purine nucleotide biosynthetic process 5.803E-10 9.831E-9 6.136E-8 1.671E-7 6 261
18 GO:0009260 ribonucleotide biosynthetic process 6.805E-10 1.089E-8 6.797E-8 1.960E-7 6 268
19 GO:0046390 ribose phosphate biosynthetic process 7.440E-10 1.095E-8 6.837E-8 2.143E-7 6 272
20 GO:0072522 purine-containing compound biosynthetic process 7.606E-10 1.095E-8 6.837E-8 2.191E-7 6 273
21 GO:0006898 receptor-mediated endocytosis 1.665E-9 2.283E-8 1.425E-7 4.795E-7 6 311
22 GO:0009165 nucleotide biosynthetic process 2.013E-9 2.636E-8 1.645E-7 5.798E-7 6 321
23 GO:1901293 nucleoside phosphate biosynthetic process 2.129E-9 2.666E-8 1.664E-7 6.131E-7 6 324
24 GO:0008277 regulation of G protein-coupled receptor signaling pathway 3.432E-7 4.119E-6 2.571E-5 9.885E-5 4 137
25 GO:0072659 protein localization to plasma membrane 2.493E-6 2.860E-5 1.785E-4 7.179E-4 4 225
26 GO:1990778 protein localization to cell periphery 2.582E-6 2.860E-5 1.785E-4 7.437E-4 4 227
27 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 6.534E-6 6.970E-5 4.351E-4 1.882E-3 3 81
28 GO:0007009 plasma membrane organization 6.918E-6 7.116E-5 4.441E-4 1.992E-3 4 291
29 GO:0097084 vascular smooth muscle cell development 7.461E-6 7.163E-5 4.471E-4 2.149E-3 2 9
30 GO:2001214 positive regulation of vasculogenesis 7.461E-6 7.163E-5 4.471E-4 2.149E-3 2 9
31 GO:0043116 negative regulation of vascular permeability 1.139E-5 1.058E-4 6.607E-4 3.281E-3 2 11
32 GO:2001212 regulation of vasculogenesis 1.615E-5 1.453E-4 9.072E-4 4.651E-3 2 13
33 GO:0006816 calcium ion transport 2.547E-5 2.223E-4 1.387E-3 7.335E-3 4 405
34 GO:0070838 divalent metal ion transport 4.020E-5 3.394E-4 2.118E-3 1.158E-2 4 455
35 GO:0072511 divalent inorganic cation transport 4.124E-5 3.394E-4 2.118E-3 1.188E-2 4 458
36 GO:0001525 angiogenesis 4.340E-5 3.472E-4 2.167E-3 1.250E-2 4 464
37 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 4.757E-5 3.703E-4 2.311E-3 1.370E-2 3 157
38 GO:0035886 vascular smooth muscle cell differentiation 6.707E-5 5.083E-4 3.173E-3 1.932E-2 2 26
39 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7.629E-5 5.634E-4 3.517E-3 2.197E-2 3 184
40 GO:0043114 regulation of vascular permeability 1.225E-4 8.821E-4 5.506E-3 3.528E-2 2 35
41 GO:0051145 smooth muscle cell differentiation 3.502E-4 2.460E-3 1.535E-2
1.009E-1
 2 59
42 GO:0001666 response to hypoxia 3.630E-4 2.489E-3 1.554E-2
1.045E-1
 3 312
43 GO:0036293 response to decreased oxygen levels 3.946E-4 2.643E-3 1.650E-2
1.136E-1
 3 321
44 GO:0070482 response to oxygen levels 4.589E-4 3.004E-3 1.875E-2
1.322E-1
 3 338
45 GO:0071329 cellular response to sucrose stimulus 4.833E-4 3.026E-3 1.889E-2
1.392E-1
 1 1
46 GO:0071324 cellular response to disaccharide stimulus 4.833E-4 3.026E-3 1.889E-2
1.392E-1
 1 1
47 GO:0001570 vasculogenesis 7.955E-4 4.874E-3 3.043E-2
2.291E-1
 2 89
48 GO:0045766 positive regulation of angiogenesis 1.764E-3 1.058E-2
6.605E-2
5.079E-1
 2 133
49 GO:1904018 positive regulation of vasculature development 2.206E-3 1.297E-2
8.094E-2
6.354E-1
 2 149
50 GO:0032355 response to estradiol 2.295E-3 1.322E-2
8.250E-2
6.608E-1
 2 152
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 7 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043235 receptor complex 4.326E-4 3.028E-3 7.851E-3 3.028E-3 3 339

4: Human Phenotype [Display Chart] 2 input genes in category / 4 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 9 input genes in category / 351 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003390 lymphedema 9.950E-8 3.492E-5 2.249E-4 3.492E-5 3 12
2 MP:0002450 abnormal lymph organ development 1.471E-6 2.582E-4 1.663E-3 5.165E-4 3 28
3 MP:0009670 abnormal uterine angiogenesis 6.706E-6 5.885E-4 3.789E-3 2.354E-3 2 5
4 MP:0012727 abnormal uterine spiral artery remodeling 6.706E-6 5.885E-4 3.789E-3 2.354E-3 2 5
5 MP:0003230 abnormal umbilical artery morphology 2.410E-5 1.692E-3 1.089E-2 8.459E-3 2 9
6 MP:0009669 abnormal postimplantation uterine environment 3.011E-5 1.761E-3 1.134E-2 1.057E-2 2 10
7 MP:0008876 decreased uterine NK cell number 6.078E-5 3.048E-3 1.963E-2 2.133E-2 2 14
8 MP:0008054 abnormal uterine NK cell morphology 1.537E-4 5.907E-3 3.804E-2
5.396E-2
 2 22
9 MP:0010776 abnormal placenta metrial gland morphology 1.537E-4 5.907E-3 3.804E-2
5.396E-2
 2 22
10 MP:0011514 skin hemorrhage 1.683E-4 5.907E-3 3.804E-2
5.907E-2
 2 23
11 MP:0012300 abnormal umbilical cord blood vessel morphology 2.509E-4 8.006E-3
5.155E-2
8.806E-2
 2 28
12 MP:0002842 increased systemic arterial blood pressure 2.840E-4 8.308E-3
5.350E-2
9.970E-2
 3 160
13 MP:0004256 abnormal maternal decidual layer morphology 3.937E-4 9.870E-3
6.356E-2
1.382E-1
 2 35
14 MP:0009671 abnormal uterus physiology 3.937E-4 9.870E-3
6.356E-2
1.382E-1
 2 35
15 MP:0004014 abnormal uterine environment 4.645E-4 1.063E-2
6.846E-2
1.630E-1
 2 38
16 MP:0002190 disorganized myocardium 4.894E-4 1.063E-2
6.846E-2
1.718E-1
 2 39
17 MP:0003888 liver hemorrhage 5.149E-4 1.063E-2
6.846E-2
1.807E-1
 2 40
18 MP:0001725 abnormal umbilical cord morphology 6.814E-4 1.329E-2
8.556E-2
2.392E-1
 2 46
19 MP:0000230 abnormal systemic arterial blood pressure 1.162E-3 2.146E-2
1.382E-1
4.078E-1
 3 259
20 MP:0003222 increased cardiomyocyte apoptosis 1.316E-3 2.310E-2
1.488E-1
4.621E-1
 2 64
21 MP:0002192 hydrops fetalis 1.399E-3 2.339E-2
1.506E-1
4.912E-1
 2 66
22 MP:0002188 small heart 1.532E-3 2.444E-2
1.574E-1
5.378E-1
 3 285
23 MP:0012302 umbilical artery stenosis 1.738E-3 2.532E-2
1.630E-1
6.099E-1
 1 2
24 MP:0020090 decreased susceptibility to diet-induced non-insulin dependent diabetes 1.738E-3 2.532E-2
1.630E-1
6.099E-1
 1 2
25 MP:0006144 increased systemic arterial systolic blood pressure 1.803E-3 2.532E-2
1.630E-1
6.329E-1
 2 75
26 MP:0003221 abnormal cardiomyocyte apoptosis 2.049E-3 2.730E-2
1.758E-1
7.191E-1
 2 80
27 MP:0005264 glomerulosclerosis 2.100E-3 2.730E-2
1.758E-1
7.370E-1
 2 81
28 MP:0011099 lethality throughout fetal growth and development, complete penetrance 2.355E-3 2.953E-2
1.901E-1
8.268E-1
 3 331
29 MP:0020088 decreased susceptibility to non-insulin-dependent diabetes 2.605E-3 3.153E-2
2.031E-1
9.145E-1
 1 3
30 MP:0014109 increased pancreatic alpha cell proliferation 3.473E-3 3.839E-2
2.472E-1
1.000E0
 1 4
31 MP:0010664 abnormal vitelline artery morphology 3.473E-3 3.839E-2
2.472E-1
1.000E0
 1 4
32 MP:0005592 abnormal vascular smooth muscle morphology 3.500E-3 3.839E-2
2.472E-1
1.000E0
 2 105
33 MP:0003638 abnormal response/metabolism to endogenous compounds 3.972E-3 4.116E-2
2.651E-1
1.000E0
 2 112
34 MP:0008045 decreased NK cell number 4.112E-3 4.116E-2
2.651E-1
1.000E0
 2 114
35 MP:0011091 prenatal lethality, complete penetrance 4.154E-3 4.116E-2
2.651E-1
1.000E0
 3 404
36 MP:0003365 increased glucagonoma incidence 4.339E-3 4.116E-2
2.651E-1
1.000E0
 1 5
37 MP:0020396 abnormal social recognition 4.339E-3 4.116E-2
2.651E-1
1.000E0
 1 5
38 MP:0000249 abnormal blood vessel physiology 4.666E-3 4.249E-2
2.736E-1
1.000E0
 3 421
39 MP:0011947 abnormal fluid intake 5.157E-3 4.249E-2
2.736E-1
1.000E0
 2 128
40 MP:0011526 abnormal placenta fetal blood space morphology 5.205E-3 4.249E-2
2.736E-1
1.000E0
 1 6
41 MP:0030589 increased pancreatic alpha cell mass 5.205E-3 4.249E-2
2.736E-1
1.000E0
 1 6
42 MP:0020338 abnormal hippocampal pyramidal neuron dendrite morphology 5.205E-3 4.249E-2
2.736E-1
1.000E0
 1 6
43 MP:0020086 abnormal susceptibility to non-insulin-dependent diabetes 5.205E-3 4.249E-2
2.736E-1
1.000E0
 1 6
44 MP:0005312 pericardial effusion 6.055E-3 4.632E-2
2.982E-1
1.000E0
 2 139
45 MP:0009179 abnormal pancreatic alpha cell differentiation 6.070E-3 4.632E-2
2.982E-1
1.000E0
 1 7
46 MP:0009394 increased uterine NK cell number 6.070E-3 4.632E-2
2.982E-1
1.000E0
 1 7
47 MP:0002710 increased glucagon secretion 6.934E-3 4.977E-2
3.205E-1
1.000E0
 1 8
48 MP:0020337 abnormal pyramidal neuron dendrite morphology 6.934E-3 4.977E-2
3.205E-1
1.000E0
 1 8
49 MP:0001422 abnormal drinking behavior 7.202E-3 4.977E-2
3.205E-1
1.000E0
 2 152
50 MP:0000767 abnormal smooth muscle morphology 7.480E-3 4.977E-2
3.205E-1
1.000E0
 2 155
Show 45 more annotations

6: Domain [Display Chart] 9 input genes in category / 24 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR006985 RAMP InterPro 7.665E-11 9.199E-10 3.473E-9 1.840E-9 3 3
2 PF04901 RAMP Pfam 7.665E-11 9.199E-10 3.473E-9 1.840E-9 3 3
3 SM00008 HormR SMART 3.092E-10 2.474E-9 9.340E-9 7.421E-9 4 25
4 PF02793 HRM Pfam 5.002E-10 3.001E-9 1.133E-8 1.200E-8 4 28
5 IPR017983 GPCR 2 secretin-like CS InterPro 1.131E-9 5.431E-9 2.051E-8 2.715E-8 4 34
6 IPR001879 GPCR 2 extracellular dom InterPro 2.227E-9 6.680E-9 2.522E-8 5.344E-8 4 40
7 PS50227 G PROTEIN RECEP F2 3 PROSITE 2.227E-9 6.680E-9 2.522E-8 5.344E-8 4 40
8 PS00649 G PROTEIN RECEP F2 1 PROSITE 2.227E-9 6.680E-9 2.522E-8 5.344E-8 4 40
9 PS00650 G PROTEIN RECEP F2 2 PROSITE 5.599E-9 1.344E-8 5.074E-8 1.344E-7 4 50
10 PF00002 7tm 2 Pfam 5.599E-9 1.344E-8 5.074E-8 1.344E-7 4 50
11 IPR000832 GPCR 2 secretin-like InterPro 1.183E-8 2.337E-8 8.824E-8 2.839E-7 4 60
12 IPR017981 GPCR 2-like InterPro 1.183E-8 2.337E-8 8.824E-8 2.839E-7 4 60
13 PS50261 G PROTEIN RECEP F2 4 PROSITE 1.266E-8 2.337E-8 8.824E-8 3.038E-7 4 61
14 IPR003287 GCPR 2 calcitonin rcpt fam InterPro 2.051E-7 3.517E-7 1.328E-6 4.923E-6 2 2
15 IPR001350 G10D rcpt InterPro 4.804E-4 5.765E-4 2.177E-3 1.153E-2 1 1
16 IPR001688 GPCR 2 calcitonin rcpt InterPro 4.804E-4 5.765E-4 2.177E-3 1.153E-2 1 1
17 IPR003291 GPCR 2 glucagon rcpt InterPro 4.804E-4 5.765E-4 2.177E-3 1.153E-2 1 1
18 IPR003289 GPCR 2 CGRP1 rcpt InterPro 4.804E-4 5.765E-4 2.177E-3 1.153E-2 1 1
19 IPR001710 Adrenomedullin InterPro 4.804E-4 5.765E-4 2.177E-3 1.153E-2 1 1
20 IPR002144 GPCR 2 secretin rcpt InterPro 4.804E-4 5.765E-4 2.177E-3 1.153E-2 1 1
21 IPR003290 GPCR 2 GLP1/glucagon rcpt InterPro 9.606E-4 1.098E-3 4.145E-3 2.305E-2 1 2
22 IPR001771 GPCR 2 VIP rcpt 1 InterPro 1.441E-3 1.571E-3 5.934E-3 3.457E-2 1 3
23 IPR021116 Calcitonin/adrenomedullin InterPro 2.400E-3 2.400E-3 9.062E-3
5.760E-2
 1 5
24 PF00214 Calc CGRP IAPP Pfam 2.400E-3 2.400E-3 9.062E-3
5.760E-2
 1 5
Show 19 more annotations

7: Pathway [Display Chart] 8 input genes in category / 18 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269571 Calcitonin-like ligand receptors BioSystems: REACTOME 1.138E-18 2.048E-17 7.157E-17 2.048E-17 6 10
2 1269570 Class B/2 (Secretin family receptors) BioSystems: REACTOME 7.130E-18 6.417E-17 2.243E-16 1.283E-16 8 93
3 1269575 G alpha (s) signalling events BioSystems: REACTOME 2.949E-16 1.769E-15 6.184E-15 5.308E-15 8 146
4 1269544 GPCR ligand binding BioSystems: REACTOME 2.998E-12 1.349E-11 4.715E-11 5.396E-11 8 455
5 96530 Vascular smooth muscle contraction BioSystems: KEGG 5.767E-7 2.076E-6 7.256E-6 1.038E-5 4 121
6 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 1.587E-5 4.761E-5 1.664E-4 2.856E-4 4 278
7 1269572 Glucagon-type ligand receptors BioSystems: REACTOME 1.558E-4 4.005E-4 1.400E-3 2.804E-3 2 30
8 PW:0000676 glucagon signaling pathway Pathway Ontology 3.209E-3 7.221E-3 2.524E-2
5.777E-2
 1 5
9 PW:0000227 G protein signaling via Galphas family Pathway Ontology 1.151E-2 2.302E-2
8.047E-2
2.072E-1
 1 18
10 1270108 Glucagon signaling in metabolic regulation BioSystems: REACTOME 2.101E-2 3.783E-2
1.322E-1
3.783E-1
 1 33
Show 5 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 903 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10882736 Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. Pubmed 1.364E-22 1.232E-19 9.097E-19 1.232E-19 6 7
2 12036966 Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. Pubmed 7.561E-22 3.414E-19 2.521E-18 6.827E-19 8 70
3 12419522 Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats. Pubmed 1.861E-19 5.602E-17 4.136E-16 1.680E-16 5 5
4 10777702 Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis. Pubmed 1.117E-18 1.440E-16 1.063E-15 1.008E-15 5 6
5 9620797 RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Pubmed 1.117E-18 1.440E-16 1.063E-15 1.008E-15 5 6
6 15300632 [Increased atria expression of receptor activity-modifying proteins in heart failure patients]. Pubmed 1.117E-18 1.440E-16 1.063E-15 1.008E-15 5 6
7 22500019 Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. Pubmed 1.117E-18 1.440E-16 1.063E-15 1.008E-15 5 6
8 14722252 Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. Pubmed 3.907E-18 3.920E-16 2.895E-15 3.528E-15 5 7
9 15613468 Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. Pubmed 3.907E-18 3.920E-16 2.895E-15 3.528E-15 5 7
10 18240029 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Pubmed 4.400E-18 3.973E-16 2.933E-15 3.973E-15 8 200
11 24831942 Expression and distribution of the adrenomedullin system in newborn human thymus. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
12 24169318 Adrenomedullin expression in the developing human fetal lung. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
13 11973435 Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
14 11854283 Respective roles of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP) in cell surface expression of CRLR/RAMP heterodimeric receptors. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
15 11060459 Genomic structure and chromosome mapping of human and mouse RAMP genes. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
16 11387328 Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
17 12565884 Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
18 10854696 Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
19 12093471 Molecular cloning and pharmacological characterization of bovine calcitonin receptor-like receptor from bovine aortic endothelial cells. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
20 27940069 Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice. Pubmed 1.421E-15 6.418E-14 4.738E-13 1.284E-12 4 4
21 22563471 Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice. Pubmed 7.106E-15 3.056E-13 2.256E-12 6.417E-12 4 5
22 18097473 The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. Pubmed 9.946E-14 4.082E-12 3.014E-11 8.981E-11 4 8
23 27402918 Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy. Pubmed 4.687E-13 1.840E-11 1.359E-10 4.233E-10 4 11
24 28727763 Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. Pubmed 7.030E-13 2.645E-11 1.953E-10 6.348E-10 4 12
25 19210874 Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
26 10354609 RAMPs: accessory proteins for seven transmembrane domain receptors. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
27 22102369 Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
28 25010197 Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
29 25982113 Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
30 27013657 Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
31 11693189 Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
32 15245870 Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
33 24199627 Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
34 16410241 Functions of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and adrenomedullin receptors. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
35 18593822 Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
36 18384073 Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
37 16912219 A critical role for the short intracellular C terminus in receptor activity-modifying protein function. Pubmed 9.047E-12 2.208E-10 1.630E-9 8.170E-9 3 3
38 11804624 Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture. Pubmed 3.618E-11 8.169E-10 6.031E-9 3.267E-8 3 4
39 12446722 Novel receptor partners and function of receptor activity-modifying proteins. Pubmed 3.618E-11 8.169E-10 6.031E-9 3.267E-8 3 4
40 10385705 Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Pubmed 3.618E-11 8.169E-10 6.031E-9 3.267E-8 3 4
41 20596610 Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells. Pubmed 9.045E-11 1.992E-9 1.471E-8 8.168E-8 3 5
42 20074556 Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. Pubmed 1.809E-10 3.889E-9 2.871E-8 1.633E-7 3 6
43 18097475 Adrenomedullin signaling is necessary for murine lymphatic vascular development. Pubmed 3.165E-10 6.647E-9 4.907E-8 2.858E-7 3 7
44 16622024 A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
45 24505304 Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
46 8977434 Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
47 9460649 Adrenomedullin expression in the mouse mammary gland: evidence for the mature form in milk. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
48 12574158 The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
49 17310067 Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
50 23297372 Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Pubmed 4.936E-8 5.436E-7 4.013E-6 4.457E-5 2 2
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 47 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CALCRL CALCRL interactions 8.119E-17 3.816E-15 1.693E-14 3.816E-15 5 7
2 int:CALCA CALCA interactions 3.589E-12 8.435E-11 3.743E-10 1.687E-10 4 10
3 int:SLC31A2 SLC31A2 interactions 1.211E-9 1.897E-8 8.418E-8 5.690E-8 3 6
4 int:RAMP1 RAMP1 interactions 7.258E-9 8.528E-8 3.785E-7 3.411E-7 3 10
5 int:RAMP3 RAMP3 interactions 9.977E-9 9.379E-8 4.162E-7 4.689E-7 3 11
6 int:CALCR CALCR interactions 1.330E-8 1.042E-7 4.624E-7 6.251E-7 3 12
7 int:VIPR1 VIPR1 interactions 6.896E-7 4.630E-6 2.055E-5 3.241E-5 3 42
8 int:RAMP2 RAMP2 interactions 2.678E-6 1.573E-5 6.982E-5 1.259E-4 2 6
9 int:ADM ADM interactions 3.748E-6 1.958E-5 8.687E-5 1.762E-4 2 7
10 int:IAPP IAPP interactions 4.997E-6 2.348E-5 1.042E-4 2.348E-4 2 8
11 int:CPAMD8 CPAMD8 interactions 2.258E-3 8.843E-3 3.924E-2
1.061E-1
 1 5
12 int:SCT SCT interactions 2.258E-3 8.843E-3 3.924E-2
1.061E-1
 1 5
13 int:DPYS DPYS interactions 2.709E-3 9.793E-3 4.346E-2
1.273E-1
 1 6
14 int:GCGR GCGR interactions 3.160E-3 1.061E-2 4.707E-2
1.485E-1
 1 7
15 int:GCG GCG interactions 4.061E-3 1.247E-2
5.535E-2
1.909E-1
 1 9
16 int:SCTR SCTR interactions 4.511E-3 1.247E-2
5.535E-2
2.120E-1
 1 10
17 int:DNAL4 DNAL4 interactions 4.511E-3 1.247E-2
5.535E-2
2.120E-1
 1 10
18 int:MBL2 MBL2 interactions 4.961E-3 1.295E-2
5.749E-2
2.332E-1
 1 11
19 int:EDN1 EDN1 interactions 5.411E-3 1.339E-2
5.940E-2
2.543E-1
 1 12
20 int:HSPB3 HSPB3 interactions 8.556E-3 2.011E-2
8.923E-2
4.021E-1
 1 19
21 int:CALM1 CALM1 interactions 9.757E-3 2.115E-2
9.387E-2
4.586E-1
 2 344
22 int:CFH CFH interactions 9.901E-3 2.115E-2
9.387E-2
4.653E-1
 1 22
23 int:CRCP CRCP interactions 1.169E-2 2.389E-2
1.060E-1
5.495E-1
 1 26
24 int:ADCYAP1 ADCYAP1 interactions 1.526E-2 2.989E-2
1.327E-1
7.174E-1
 1 34
25 int:GPRASP1 GPRASP1 interactions 2.371E-2 4.365E-2
1.937E-1
1.000E0
 1 53
26 int:THBS1 THBS1 interactions 2.415E-2 4.365E-2
1.937E-1
1.000E0
 1 54
Show 21 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q36-q37.1 2q36-q37.1 2.597E-4 2.337E-3 6.611E-3 2.337E-3 1 1
2 17q12-q21.1 17q12-q21.1 7.788E-4 3.505E-3 9.914E-3 7.009E-3 1 3
3 7p13-p12 7p13-p12 1.816E-3 5.449E-3 1.542E-2 1.635E-2 1 7
4 2q14.1 2q14.1 4.923E-3 1.108E-2 3.134E-2 4.431E-2 1 19
5 2q32.1 2q32.1 8.022E-3 1.429E-2 4.041E-2
7.219E-2
 1 31
6 17q25 17q25 1.008E-2 1.429E-2 4.041E-2
9.074E-2
 1 39
7 7q21.3 7q21.3 1.111E-2 1.429E-2 4.041E-2
1.000E-1
 1 43
8 12q13.3 12q13.3 1.342E-2 1.510E-2 4.272E-2
1.208E-1
 1 52
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 50 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 9 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 718 Receptor (G protein-coupled) activity modifying proteins genenames.org 8.370E-11 4.185E-10 9.556E-10 4.185E-10 3 3
2 265 Calcitonin receptors genenames.org 2.175E-7 5.438E-7 1.242E-6 1.088E-6 2 2
3 269 Glucagon receptor family genenames.org 3.259E-6 5.432E-6 1.240E-5 1.630E-5 2 6
4 262 G protein-coupled receptors, Class A orphans genenames.org 3.794E-2 4.742E-2
1.083E-1
1.897E-1
 1 78

13: Coexpression [Display Chart] 9 input genes in category / 1136 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16675456-table1 Mouse StemCell Zhou06 49genes GeneSigDB 4.306E-7 4.892E-4 3.724E-3 4.892E-4 3 41
2 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 3.450E-6 1.960E-3 1.492E-2 3.919E-3 4 303
3 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.441E-5 4.128E-3 3.142E-2 1.637E-2 4 435
4 M1461 Genes up-regulated in LEC (lymphatic endothelial cells) compared to BEC (blood endothelial cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.453E-5 4.128E-3 3.142E-2 1.651E-2 3 131
5 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 1.826E-5 4.149E-3 3.159E-2 2.075E-2 4 462
6 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.899E-5 5.488E-3 4.178E-2 3.293E-2 3 165
7 M1307 Genes down-regulated in SEND cells (skin endothelium) at normal oxygen (normoxia) conditions after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.016E-5 6.493E-3 4.943E-2 4.563E-2 2 25
8 M7258 Genes down-regulated in thymocytes: cortical versus medullary sources. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 6.493E-3 4.943E-2
5.757E-2
 3 199
9 M8647 Genes down-regulated in bone marrow-derived macrophages: wildtype versus NFAT5 [GeneID=10725] knockout. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 6.493E-3 4.943E-2
5.843E-2
 3 200
10 M1456 Genes commonly expressed in long term hematopoietic stem cells (HSC) and multipotent progenitors (MPP). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.632E-4 1.854E-2
1.411E-1
1.854E-1
 2 50
11 M6315 Cluster 2: genes down-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.763E-4 2.853E-2
2.172E-1
3.139E-1
 3 353
12 16488994-SuppTable1b Mouse Lung Lu06 856genes Array MEO430Av2 GeneSigDB 5.374E-4 3.844E-2
2.926E-1
6.105E-1
 3 443
13 16488994-SuppTable1a Mouse Lung Lu06 856genes Array MG U74Av2 GeneSigDB 5.590E-4 3.844E-2
2.926E-1
6.350E-1
 3 449
14 M5451 Survival signature genes defined in adjacent liver tissue: genes correlated with good survival of hepatocellular carcinoma (HCC) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.323E-4 3.844E-2
2.926E-1
9.455E-1
 2 113
15 M7969 Genes down-regulated in wildtype bone marrow-derived macrophages treated with rosiglitazone [PubChem=77999]: control versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 8.767E-4 3.844E-2
2.926E-1
9.960E-1
 2 116
16 20559987-TableS4 Rat Heart Lara-Pezzi09 genes GeneSigDB 8.918E-4 3.844E-2
2.926E-1
1.000E0
 2 117
17 15705887-Table2 Mouse Colon Ma05 07genes GeneSigDB 1.167E-3 3.844E-2
2.926E-1
1.000E0
 1 3
18 M13907 Down-regulated in brown preadipocytes with IRS1 [GeneID=3667] knockout vs wild type controls; the knockouts have severe defects in adipocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.184E-3 3.844E-2
2.926E-1
1.000E0
 2 135
19 M5825 Angiogenic markers down-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.237E-3 3.844E-2
2.926E-1
1.000E0
 2 138
20 17161497-SuppTable1 Human Lung Dracheva07 162genes GeneSigDB 1.383E-3 3.844E-2
2.926E-1
1.000E0
 2 146
21 16498405-TableS7 Mouse Kidney Takemoto06 208genes cat5 GeneSigDB 1.440E-3 3.844E-2
2.926E-1
1.000E0
 2 149
22 M1304 Genes down-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.576E-3 3.844E-2
2.926E-1
1.000E0
 2 156
23 M6923 Genes down-regulated in B lymphocytes: control versus PL2-3 (Chromatin IC). MSigDB C7: Immunologic Signatures (v6.0) 1.782E-3 3.844E-2
2.926E-1
1.000E0
 2 166
24 M2638 Genes down-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 3h. MSigDB C6: Oncogenic Signatures (v6.0) 1.825E-3 3.844E-2
2.926E-1
1.000E0
 2 168
25 M6316 Genes up-regulated in macrophages: control versus Sendai virus infection. MSigDB C7: Immunologic Signatures (v6.0) 1.868E-3 3.844E-2
2.926E-1
1.000E0
 2 170
26 M6691 Genes down-regulated in fibroblasts: interferon alpha versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.160E-3 3.844E-2
2.926E-1
1.000E0
 2 183
27 19235837-TableS2b Human Pancreas Cavard09 233genes GeneSigDB 2.253E-3 3.844E-2
2.926E-1
1.000E0
 2 187
28 M8132 Genes down-regulated in decidual macrophages with ITGAX [GeneID=3687] high versus low. MSigDB C7: Immunologic Signatures (v6.0) 2.325E-3 3.844E-2
2.926E-1
1.000E0
 2 190
29 M2698 Genes up-regulated in NCI-60 panel of cell lines with mutated TP53 [Gene ID=7157]. MSigDB C6: Oncogenic Signatures (v6.0) 2.422E-3 3.844E-2
2.926E-1
1.000E0
 2 194
30 M8345 Genes down-regulated in activated versus induced T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 3.844E-2
2.926E-1
1.000E0
 2 196
31 M6180 Genes up-regulated in C57BL6 CD4 CD8 double positive thymocyte transgenic for the BDC2.5 TCR incubated with no peptide 0h versus C57BL6 CD4 CD8 double positive thymocyte transgenic for the BDC2.5 TCR incubated with mimetope negative sel 16h. MSigDB C7: Immunologic Signatures (v6.0) 2.472E-3 3.844E-2
2.926E-1
1.000E0
 2 196
32 M5855 Genes down-regulated in comparison of monocytes treated with 5000 ng/ml LPS (TLR4 agonist) versus those treated with 1 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 3.844E-2
2.926E-1
1.000E0
 2 197
33 M9817 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.844E-2
2.926E-1
1.000E0
 2 198
34 M5405 Genes down-regulated in comparison of eosinophils versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.844E-2
2.926E-1
1.000E0
 2 198
35 M7558 Genes up-regulated in CD11b+ cells from spleen of BALB/c mice: healthy versus bearing C26GM colon carcinoma. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.844E-2
2.926E-1
1.000E0
 2 199
36 M9924 Genes up-regulated in B lymphocytes: untreated versus anti-IgM for 24h. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.844E-2
2.926E-1
1.000E0
 2 199
37 M5454 Genes down-regulated in comparison of mast cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.844E-2
2.926E-1
1.000E0
 2 199
38 M8743 Genes down-regulated in STAT5 double knock-in T cells: control versus IL2 [GeneID=3558] stimulation for 17h. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.844E-2
2.926E-1
1.000E0
 2 199
39 M3460 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.844E-2
2.926E-1
1.000E0
 2 199
40 M7233 Genes up-regulated in T cells: control (0h) versus IL21 [GeneID=59067] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
41 M5705 Genes down-regulated in comparsion of sfActCD4TGF versus ActCD4TGF (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
42 M6583 Genes down-regulated in monocytes: untreated versus CSF1 [GeneID=1435] knockout at day 3. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
43 M5452 Genes down-regulated in comparison of mast cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
44 M6276 Genes up-regulated in medullary thymic epithelial cells (mTEC): CD80 [GeneID=941] high versus low. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
45 M9920 Genes down-regulated in B lymphocytes with MAP3K7 [GeneID=6885] knockout: untreated versus anti IgM for 24h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
46 M8110 Genes down-regulated in unstimulated macrophages: IL10 [GeneID=3586] knockout versus NFKB1 [GeneID=4790] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
47 M7235 Genes up-regulated in thymus cortical regions: subcapsular versus perimedullary. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
48 M9035 Genes up-regulated in macrophages with heterozygous knockout of HDAC3 [GeneID=8841]: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
49 M4043 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
50 M6580 Genes down-regulated in ITGAM+ [GeneID=3684] cells from spleens of tumor bearing mice: processed immediately versus those incubated for 24h in complete medium. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.844E-2
2.926E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 1018 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap kidney e15.5 SmlBldVes Tie2 k4 500 kidney e15.5 SmlBldVes Tie2 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.772E-7 6.334E-4 4.753E-3 6.894E-4 4 190
2 gudmap kidney adult GlomCapSys Tie2 k1 200 kidney adult GlomCapSys Tie2 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.639E-6 6.334E-4 4.753E-3 1.668E-3 3 60
3 gudmap kidney adult GlomCapSys Tie2 k3 1000 kidney adult GlomCapSys Tie2 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.867E-6 6.334E-4 4.753E-3 1.900E-3 4 245
4 gudmap kidney e15.5 SmlBldVes Tie2 k4 1000 kidney e15.5 SmlBldVes Tie2 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.501E-6 8.909E-4 6.685E-3 3.564E-3 4 287
5 gudmap kidney e15.5 SmlBldVes Tie2 k2 200 kidney e15.5 SmlBldVes Tie2 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 7.008E-6 1.404E-3 1.053E-2 7.134E-3 3 97
6 gudmap developingKidney e15.5 stage III -IV renal corpusc 1000 k3 DevelopingKidney e15.5 stage III -IV renal corpusc emap-27945 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.395E-6 1.404E-3 1.053E-2 8.546E-3 3 103
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal Wilms Fetus other/Kidney Normal Wilms F9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal Wilms Fetus other/Kidney Normal Wilms F9 Adult, Development, and Cancer types 9.681E-6 1.404E-3 1.053E-2 9.856E-3 3 108
8 gudmap kidney adult RenCorpuscGlomer k2 500 kidney adult RenCorpuscGlomer k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.200E-5 1.404E-3 1.053E-2 1.222E-2 3 116
9 gudmap kidney e15.5 SmlBldVes Tie2 500 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.476E-5 1.404E-3 1.053E-2 1.502E-2 4 413
10 gudmap kidney adult RenMedVasc Tie2 500 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.533E-5 1.404E-3 1.053E-2 1.561E-2 4 417
11 gudmap kidney adult RenCorpuscGlomer 500 kidney adult RenCorpuscGlomer top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.860E-5 1.404E-3 1.053E-2 1.893E-2 4 438
12 GSM777059 500 Stromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 1.877E-5 1.404E-3 1.053E-2 1.911E-2 4 439
13 facebase RNAseq e8.5 ParaxMesoderm 2500 K3 facebase RNAseq e8.5 ParaxMesoderm 2500 K3 Gudmap RNAseq 1.933E-5 1.404E-3 1.053E-2 1.968E-2 3 136
14 gudmap kidney adult GlomCapSys Tie2 k4 500 kidney adult GlomCapSys Tie2 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.976E-5 1.404E-3 1.053E-2 2.012E-2 3 137
15 GSM777063 500 Stromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4 Immgen.org, GSE15907 2.068E-5 1.404E-3 1.053E-2 2.106E-2 4 450
16 gudmap kidney adult CortVasc Tie2 k3 500 kidney adult CortVasc Tie2 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.322E-5 1.897E-3 1.424E-2 3.382E-2 3 163
17 gudmap dev gonad e11.5 F ReproVasc Flk k3 100 dev gonad e11.5 F ReproVasc Flk k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.476E-5 1.897E-3 1.424E-2 3.538E-2 2 22
18 gudmap kidney adult GlomCapSys Tie2 200 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.968E-5 1.897E-3 1.424E-2 4.039E-2 3 173
19 gudmap kidney e15.5 SmlBldVes Tie2 200 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.392E-5 1.897E-3 1.424E-2 4.471E-2 3 179
20 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/endothelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/endothelial cell Tabula Muris Consortium 4.466E-5 1.897E-3 1.424E-2 4.546E-2 3 180
21 lung lung Human Protein Atlas 4.615E-5 1.897E-3 1.424E-2 4.698E-2 3 182
22 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Aorta/endothelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Aorta/endothelial cell Tabula Muris Consortium 4.691E-5 1.897E-3 1.424E-2 4.776E-2 3 183
23 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/lung endothelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/lung endothelial cell Tabula Muris Consortium 4.691E-5 1.897E-3 1.424E-2 4.776E-2 3 183
24 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/endothelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/endothelial cell Tabula Muris Consortium 4.691E-5 1.897E-3 1.424E-2 4.776E-2 3 183
25 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung Tabula Muris Consortium 4.768E-5 1.897E-3 1.424E-2 4.854E-2 3 184
26 gudmap RNAseq p2 Glomerlular Endothelial 2500 K3 gudmap RNAseq p2 Glomerlular Endothelial 2500 K3 Gudmap RNAseq 4.846E-5 1.897E-3 1.424E-2 4.933E-2 3 185
27 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/endothelial cell of hepatic sinusoid Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/endothelial cell of hepatic sinusoid Tabula Muris Consortium 5.164E-5 1.929E-3 1.448E-2
5.257E-2
 3 189
28 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/endocardial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/endocardial cell Tabula Muris Consortium 5.329E-5 1.929E-3 1.448E-2
5.425E-2
 3 191
29 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q BrainMap 5.496E-5 1.929E-3 1.448E-2
5.595E-2
 3 193
30 Endothelial cells (ED) Endothelial cells (ED) 5.931E-5 1.977E-3 1.483E-2
6.038E-2
 3 198
31 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Endothelial cells (ED) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Endothelial cells (ED) Fetal, Development 6.020E-5 1.977E-3 1.483E-2
6.129E-2
 3 199
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R7 Adult, Development, and Cancer types 1.054E-4 3.353E-3 2.516E-2
1.073E-1
 2 38
33 gudmap dev gonad e12.5 F gudmap devVasOvary Flk k3 200 dev gonad e12.5 F DevVasOvary Flk k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.229E-4 3.791E-3 2.844E-2
1.251E-1
 2 41
34 gudmap RNAseq e15.5 CollectIng Duct 2500 K3 gudmap RNAseq e15.5 CollectIng Duct 2500 K3 Gudmap RNAseq 1.286E-4 3.850E-3 2.888E-2
1.309E-1
 3 257
35 gudmap kidney e15.5 SmlBldVes Tie2 k1 100 kidney e15.5 SmlBldVes Tie2 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.618E-4 4.706E-3 3.531E-2
1.647E-1
 2 47
36 gudmap developingKidney e15.5 stage III -IV renal corpusc 500 k1 DevelopingKidney e15.5 stage III -IV renal corpusc emap-27945 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.982E-4 5.457E-3 4.095E-2
2.018E-1
 2 52
37 gudmap dev gonad e11.5 M ReproVasc Flk k2 100 dev gonad e11.5 M ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.060E-4 5.457E-3 4.095E-2
2.097E-1
 2 53
38 gudmap kidney adult CortVasc Tie2 k2 1000 kidney adult CortVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.070E-4 5.457E-3 4.095E-2
2.108E-1
 3 302
39 gudmap developingKidney e15.5 Endothelial cells 1000 k2 DevelopingKidney e15.5 Endothelial cells emap-29965 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.091E-4 5.457E-3 4.095E-2
2.128E-1
 3 303
40 gudmap kidney adult RenMedVasc Tie2 k2 1000 kidney adult RenMedVasc Tie2 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.279E-4 5.800E-3 4.352E-2
2.320E-1
 3 312
41 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Cspg5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Cspg5 Top 200 Genes BrainMap 3.063E-4 7.605E-3
5.707E-2
3.118E-1
 3 345
42 Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Subtype P0-Six2TGC Tsc1-Endo-C8-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Subtype P0-Six2TGC Tsc1-Endo-C8-KC1 Top 200 Genes 3.414E-4 8.096E-3
6.074E-2
3.476E-1
 3 358
43 Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Top 200 Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Top 200 3.499E-4 8.096E-3
6.074E-2
3.562E-1
 3 361
44 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes 3.499E-4 8.096E-3
6.074E-2
3.562E-1
 3 361
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal fetal kidney Ureter epithelium/Kidney Normal fetal kidney U3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal fetal kidney Ureter epithelium/Kidney Normal fetal kidney U3 Adult, Development, and Cancer types 4.239E-4 9.589E-3
7.195E-2
4.315E-1
 2 76
46 gudmap kidney adult RenMedVasc Tie2 100 kidney adult RenMedVasc Tie2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.176E-4 1.132E-2
8.492E-2
5.269E-1
 2 84
47 gudmap developingKidney e15.5 stage III -IV renal corpusc 500 DevelopingKidney e15.5 stage III -IV renal corpusc emap-27945 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.225E-4 1.132E-2
8.492E-2
5.319E-1
 3 414
48 gudmap kidney adult CortVasc Tie2 500 kidney adult CortVasc Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.374E-4 1.140E-2
8.552E-2
5.471E-1
 3 418
49 gudmap kidney e15.5 SmlBldVes Tie2 100 kidney e15.5 SmlBldVes Tie2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.679E-4 1.164E-2
8.737E-2
5.781E-1
 2 88
50 gudmap kidney adult GlomCapSys Tie2 500 kidney adult GlomCapSys Tie2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.719E-4 1.164E-2
8.737E-2
5.822E-1
 3 427
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.152E-3 3.634E-2
1.517E-1
7.747E-2
 3 355
2 M6672 MODULE 146 Genes in the cancer module 146. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.752E-3 3.634E-2
1.517E-1
9.906E-2
 2 102
3 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.821E-3 3.634E-2
1.517E-1
1.376E-1
 3 434
4 M12584 MODULE 289 Genes in the cancer module 289. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.038E-3 3.634E-2
1.517E-1
1.454E-1
 2 124
5 M10197 MODULE 92 Secreted signaling molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.780E-3 4.162E-2
1.737E-1
2.081E-1
 2 149
6 M11146 MODULE 65 Genes in the cancer module 65. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.946E-3 4.767E-2
1.990E-1
2.860E-1
 1 10
Show 1 more annotation

16: MicroRNA [Display Chart] 9 input genes in category / 236 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-611:mirSVR lowEffct hsa-miR-611:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.278E-3 4.794E-2
2.897E-1
3.016E-1
 2 437
2 hsa-miR-4462:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.489E-3 4.794E-2
2.897E-1
5.874E-1
 1 20
3 hsa-miR-660-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.212E-3 4.794E-2
2.897E-1
1.000E0
 1 50
4 hsa-miR-4456:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.832E-3 4.794E-2
2.897E-1
1.000E0
 1 55
5 hsa-miR-126-3p:Functional MTI Functional MTI miRTarbase 7.079E-3 4.794E-2
2.897E-1
1.000E0
 1 57
6 hsa-miR-2277-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.327E-3 4.794E-2
2.897E-1
1.000E0
 1 59
7 hsa-miR-6509-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.794E-2
2.897E-1
1.000E0
 1 61
8 hsa-miR-938:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.794E-2
2.897E-1
1.000E0
 1 61
9 hsa-miR-6886-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.193E-3 4.794E-2
2.897E-1
1.000E0
 1 66
10 hsa-miR-921:Functional MTI Functional MTI miRTarbase 8.440E-3 4.794E-2
2.897E-1
1.000E0
 1 68
11 hsa-miR-4760-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.811E-3 4.794E-2
2.897E-1
1.000E0
 1 71
12 hsa-miR-411-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.058E-3 4.794E-2
2.897E-1
1.000E0
 1 73
13 hsa-miR-4424:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.306E-3 4.794E-2
2.897E-1
1.000E0
 1 75
14 hsa-miR-453:PITA hsa-miR-453:PITA TOP PITA 9.306E-3 4.794E-2
2.897E-1
1.000E0
 1 75
15 hsa-miR-151a-3p:TargetScan hsa-miR-151a-3p TargetScan 9.553E-3 4.794E-2
2.897E-1
1.000E0
 1 77
16 hsa-miR-380-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.553E-3 4.794E-2
2.897E-1
1.000E0
 1 77
17 hsa-miR-6511a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.676E-3 4.794E-2
2.897E-1
1.000E0
 1 78
18 hsa-miR-6511b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.800E-3 4.794E-2
2.897E-1
1.000E0
 1 79
19 hsa-miR-3975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.923E-3 4.794E-2
2.897E-1
1.000E0
 1 80
20 hsa-miR-1204:mirSVR highEffct hsa-miR-1204:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.005E-2 4.794E-2
2.897E-1
1.000E0
 1 81
21 hsa-miR-633:Functional MTI Functional MTI miRTarbase 1.005E-2 4.794E-2
2.897E-1
1.000E0
 1 81
22 hsa-miR-5087:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.029E-2 4.794E-2
2.897E-1
1.000E0
 1 83
23 hsa-miR-379-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.042E-2 4.794E-2
2.897E-1
1.000E0
 1 84
24 hsa-miR-6784-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.054E-2 4.794E-2
2.897E-1
1.000E0
 1 85
25 hsa-miR-3188:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.066E-2 4.794E-2
2.897E-1
1.000E0
 1 86
26 TCTGATA,MIR-361:MSigDB TCTGATA,MIR-361:MSigDB MSigDB 1.079E-2 4.794E-2
2.897E-1
1.000E0
 1 87
27 hsa-miR-6862-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.079E-2 4.794E-2
2.897E-1
1.000E0
 1 87
28 hsa-miR-365b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.079E-2 4.794E-2
2.897E-1
1.000E0
 1 87
29 hsa-miR-4670-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.103E-2 4.794E-2
2.897E-1
1.000E0
 1 89
30 hsa-miR-4464:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.103E-2 4.794E-2
2.897E-1
1.000E0
 1 89
31 hsa-miR-2467-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.103E-2 4.794E-2
2.897E-1
1.000E0
 1 89
32 GTTATAT,MIR-410:MSigDB GTTATAT,MIR-410:MSigDB MSigDB 1.116E-2 4.794E-2
2.897E-1
1.000E0
 1 90
33 hsa-miR-4748:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 4.794E-2
2.897E-1
1.000E0
 1 90
34 hsa-miR-374c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.177E-2 4.794E-2
2.897E-1
1.000E0
 1 95
35 hsa-miR-6742-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.214E-2 4.794E-2
2.897E-1
1.000E0
 1 98
36 hsa-miR-938:PITA hsa-miR-938:PITA TOP PITA 1.214E-2 4.794E-2
2.897E-1
1.000E0
 1 98
37 hsa-miR-4664-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.214E-2 4.794E-2
2.897E-1
1.000E0
 1 98
38 hsa-miR-483-3p.1:TargetScan hsa-miR-483-3p.1 TargetScan 1.227E-2 4.794E-2
2.897E-1
1.000E0
 1 99
39 hsa-miR-7850-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.239E-2 4.794E-2
2.897E-1
1.000E0
 1 100
40 hsa-miR-6812-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.251E-2 4.794E-2
2.897E-1
1.000E0
 1 101
41 hsa-miR-655-3p:Functional MTI Functional MTI miRTarbase 1.251E-2 4.794E-2
2.897E-1
1.000E0
 1 101
42 hsa-miR-6737-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.264E-2 4.794E-2
2.897E-1
1.000E0
 1 102
43 hsa-miR-6819-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.276E-2 4.794E-2
2.897E-1
1.000E0
 1 103
44 hsa-miR-329-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.276E-2 4.794E-2
2.897E-1
1.000E0
 1 103
45 GGGCATT,MIR-365:MSigDB GGGCATT,MIR-365:MSigDB MSigDB 1.288E-2 4.794E-2
2.897E-1
1.000E0
 1 104
46 hsa-miR-338-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.301E-2 4.794E-2
2.897E-1
1.000E0
 1 105
47 hsa-miR-151-3p:PITA hsa-miR-151-3p:PITA TOP PITA 1.301E-2 4.794E-2
2.897E-1
1.000E0
 1 105
48 hsa-miR-4666a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.325E-2 4.794E-2
2.897E-1
1.000E0
 1 107
49 hsa-miR-3174:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.325E-2 4.794E-2
2.897E-1
1.000E0
 1 107
50 hsa-miR-4316:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.325E-2 4.794E-2
2.897E-1
1.000E0
 1 107
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 2022 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000072887 1-piperidinecarboxamide Stitch 3.601E-22 7.281E-19 5.963E-18 7.281E-19 7 15
2 CID000041384 carbosulfan Stitch 3.834E-16 3.876E-13 3.174E-12 7.752E-13 7 89
3 DB01278 Pramlintide Drug Bank 1.111E-14 7.490E-12 6.134E-11 2.247E-11 4 4
4 CID000018835 Ebna Stitch 6.707E-14 3.390E-11 2.777E-10 1.356E-10 7 183
5 CID000073188 3 at 1 Stitch 4.118E-13 1.666E-10 1.364E-9 8.328E-10 5 31
6 CID005310945 NF449 Stitch 5.751E-13 1.938E-10 1.587E-9 1.163E-9 5 33
7 CID000447083 S)-ACPA Stitch 7.640E-12 2.207E-9 1.807E-8 1.545E-8 5 54
8 CID005281707 coumestrol Stitch 2.709E-11 6.847E-9 5.607E-8 5.478E-8 5 69
9 CID000190217 oxIde Stitch 3.480E-10 7.819E-8 6.403E-7 7.037E-7 4 31
10 CID000005560 trichlormethiazide Stitch 3.977E-10 8.041E-8 6.585E-7 8.041E-7 4 32
11 CID000005270 SQ22536 Stitch 8.277E-10 1.521E-7 1.246E-6 1.674E-6 5 135
12 CID000122591 E 14 Stitch 9.085E-10 1.531E-7 1.254E-6 1.837E-6 4 39
13 CID000123854 bis(sulfosuccinimidyl) suberate Stitch 1.009E-9 1.570E-7 1.286E-6 2.041E-6 4 40
14 CID000010457 suberate Stitch 4.349E-9 6.281E-7 5.144E-6 8.794E-6 4 57
15 CID000449606 AC1L9NAZ Stitch 5.701E-9 7.685E-7 6.293E-6 1.153E-5 5 198
16 CID006433156 bomyl Stitch 6.969E-9 8.806E-7 7.212E-6 1.409E-5 3 11
17 CID000009283 triphenyltetrazolium chloride Stitch 3.058E-8 3.637E-6 2.978E-5 6.182E-5 4 92
18 CID003674064 mobs Stitch 6.490E-8 7.290E-6 5.970E-5 1.312E-4 3 22
19 ctd:D009569 Nitric Oxide CTD 8.028E-8 8.543E-6 6.996E-5 1.623E-4 5 336
20 CID000021810 4-chloro-6-methyl-pyrimidin-2-amine Stitch 1.380E-7 1.395E-5 1.143E-4 2.791E-4 2 2
21 CID000003864 N(G)-nitro-L-arginine methyl ester Stitch 1.969E-7 1.896E-5 1.552E-4 3.981E-4 4 146
22 CID006426631 Rp-cAMPS Stitch 6.149E-7 5.652E-5 4.628E-4 1.243E-3 4 194
23 CID000122153 N-hydroxysuccinimidyl-4-azidobenzoate Stitch 8.726E-7 7.671E-5 6.282E-4 1.764E-3 3 51
24 ctd:D002762 Cholecalciferol CTD 1.367E-6 1.116E-4 9.136E-4 2.764E-3 4 237
25 CID000402339 AC1L8JB9 Stitch 1.379E-6 1.116E-4 9.136E-4 2.789E-3 2 5
26 CID000009638 Sonazoid Stitch 9.090E-6 7.069E-4 5.789E-3 1.838E-2 2 12
27 CID000003541 AC1MBZ1C Stitch 9.559E-6 7.159E-4 5.862E-3 1.933E-2 4 387
28 CID000005839 aldosterone Stitch 1.057E-5 7.634E-4 6.252E-3 2.138E-2 4 397
29 CID000130705 9-OH-B220 Stitch 1.376E-5 9.427E-4 7.720E-3 2.782E-2 3 127
30 CID000025476 Hypertensin II Stitch 1.435E-5 9.427E-4 7.720E-3 2.901E-2 4 429
31 CID000132534 NA-382 Stitch 1.445E-5 9.427E-4 7.720E-3 2.922E-2 2 15
32 CID000122148 AC1L3U2V Stitch 2.105E-5 1.290E-3 1.056E-2 4.256E-2 2 18
33 CID000069319 phenyl azide Stitch 2.105E-5 1.290E-3 1.056E-2 4.256E-2 2 18
34 CID000114813 AC1Q5H8E Stitch 2.220E-5 1.321E-3 1.081E-2 4.490E-2 3 149
35 CID005288571 AC1NRBPT Stitch 2.851E-5 1.647E-3 1.349E-2
5.765E-2
 3 162
36 CID000197712 Letairis Stitch 3.792E-5 2.099E-3 1.719E-2
7.668E-2
 2 24
37 CID000001456 OD-q Stitch 3.840E-5 2.099E-3 1.719E-2
7.765E-2
 3 179
38 CID000006181 diiodotyrosine Stitch 4.121E-5 2.193E-3 1.796E-2
8.333E-2
 2 25
39 3977 DN Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.956E-5 2.569E-3 2.104E-2
1.002E-1
 3 195
40 CID000064392 U-37883A Stitch 5.573E-5 2.817E-3 2.307E-2
1.127E-1
 2 29
41 CID000099129 MMTS Stitch 9.631E-5 4.750E-3 3.890E-2
1.947E-1
 2 38
42 CID000005092 rolipram Stitch 1.074E-4 5.170E-3 4.234E-2
2.171E-1
 3 253
43 ctd:D006852 Hydrochlorothiazide CTD 1.236E-4 5.811E-3 4.759E-2
2.499E-1
 2 43
44 CID000004299 W-13 Stitch 1.294E-4 5.816E-3 4.763E-2
2.617E-1
 2 44
45 CID005287843 AC1NRAEQ Stitch 1.294E-4 5.816E-3 4.763E-2
2.617E-1
 2 44
46 CID000079784 tricine Stitch 1.478E-4 6.498E-3
5.321E-2
2.989E-1
 2 47
47 CID000005618 U46619 Stitch 1.527E-4 6.571E-3
5.381E-2
3.088E-1
 3 285
48 CID000001293 R1-methanandamide Stitch 1.882E-4 7.928E-3
6.493E-2
3.806E-1
 2 53
49 CID000005680 A0666 sigma Stitch 2.102E-4 8.674E-3
7.104E-2
4.250E-1
 2 56
50 CID000656900 4-iodobenzenethiol Stitch 2.495E-4 9.893E-3
8.102E-2
5.046E-1
 2 61
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 178 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0031511 Pheochromocytoma DisGeNET Curated 1.866E-7 3.321E-5 1.914E-4 3.321E-5 5 283
2 C0154946 Acute angle-closure glaucoma DisGeNET BeFree 8.224E-7 4.879E-5 2.811E-4 1.464E-4 2 3
3 C0265116 Chronic cerebral ischemia DisGeNET BeFree 8.224E-7 4.879E-5 2.811E-4 1.464E-4 2 3
4 C0265191 Chronic acquired lymphedema DisGeNET BeFree 7.664E-6 3.411E-4 1.965E-3 1.364E-3 2 8
5 C0334583 Pilocytic Astrocytoma DisGeNET Curated 2.158E-5 7.684E-4 4.427E-3 3.842E-3 3 105
6 C0007785 Cerebral Infarction DisGeNET Curated 3.157E-4 8.304E-3 4.785E-2
5.619E-2
 3 259
7 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 3.266E-4 8.304E-3 4.785E-2
5.813E-2
 3 262
8 C0085580 Essential Hypertension DisGeNET Curated 4.137E-4 9.206E-3
5.304E-2
7.364E-2
 3 284
9 C0158369 Swelling of limb DisGeNET BeFree 5.554E-4 9.886E-3
5.696E-2
9.886E-2
 1 1
10 C0694575 Macular fibrosis DisGeNET BeFree 5.554E-4 9.886E-3
5.696E-2
9.886E-2
 1 1
11 C0281361 Adenocarcinoma of pancreas DisGeNET Curated 7.243E-4 1.172E-2
6.753E-2
1.289E-1
 3 344
12 C0553718 Renal artery occlusion DisGeNET BeFree 1.110E-3 1.647E-2
9.491E-2
1.977E-1
 1 2
13 C0740391 Middle Cerebral Artery Occlusion DisGeNET BeFree 1.509E-3 1.976E-2
1.139E-1
2.685E-1
 2 107
14 C0334606 Fibrous Meningioma DisGeNET BeFree 1.665E-3 1.976E-2
1.139E-1
2.964E-1
 1 3
15 C0035319 Retinal Necrosis Syndrome, Acute DisGeNET BeFree 1.665E-3 1.976E-2
1.139E-1
2.964E-1
 1 3
16 C0747845 early pregnancy DisGeNET BeFree 2.149E-3 2.391E-2
1.378E-1
3.826E-1
 2 128
17 C0854443 Vascular fragility DisGeNET BeFree 2.774E-3 2.469E-2
1.423E-1
4.938E-1
 1 5
18 C0751887 Medullary Neoplasms DisGeNET BeFree 2.774E-3 2.469E-2
1.423E-1
4.938E-1
 1 5
19 C0023009 Speech and language disorder DisGeNET BeFree 2.774E-3 2.469E-2
1.423E-1
4.938E-1
 1 5
20 C1401086 Peripheral vascular insufficiency DisGeNET Curated 2.774E-3 2.469E-2
1.423E-1
4.938E-1
 1 5
21 C0410438 Primary osteoporosis DisGeNET BeFree 3.328E-3 2.693E-2
1.552E-1
5.924E-1
 1 6
22 cv:C0029458 Osteoporosis Clinical Variations 3.328E-3 2.693E-2
1.552E-1
5.924E-1
 1 6
23 C1960636 Dysglycemia DisGeNET BeFree 4.435E-3 3.433E-2
1.978E-1
7.895E-1
 1 8
24 OMIN:166710 OSTEOPOROSIS OMIM 4.989E-3 3.700E-2
2.132E-1
8.880E-1
 1 9
25 C0522254 Analgesic Overuse Headache DisGeNET BeFree 5.542E-3 3.946E-2
2.273E-1
9.864E-1
 1 10
26 C0020540 Malignant Hypertension DisGeNET Curated 6.094E-3 4.172E-2
2.404E-1
1.000E0
 1 11
27 C0917798 Cerebral Ischemia DisGeNET Curated 6.933E-3 4.418E-2
2.546E-1
1.000E0
 2 233
28 C0238462 Medullary carcinoma of thyroid DisGeNET Curated 7.107E-3 4.418E-2
2.546E-1
1.000E0
 2 236
29 C1257877 Pheochromocytoma, Extra-Adrenal DisGeNET Curated 7.199E-3 4.418E-2
2.546E-1
1.000E0
 1 13
30 C0752304 Hypoxic-Ischemic Encephalopathy DisGeNET BeFree 7.750E-3 4.450E-2
2.564E-1
1.000E0
 1 14
31 C0017689 Glucagonoma DisGeNET Curated 7.750E-3 4.450E-2
2.564E-1
1.000E0
 1 14
32 C0043515 Zollinger-Ellison syndrome DisGeNET Curated 8.302E-3 4.478E-2
2.580E-1
1.000E0
 1 15
33 C0022118 Transient ischemia DisGeNET BeFree 8.302E-3 4.478E-2
2.580E-1
1.000E0
 1 15
34 C0004045 Asphyxia Neonatorum DisGeNET Curated 8.853E-3 4.524E-2
2.607E-1
1.000E0
 1 16
35 C0017605 Angle Closure Glaucoma DisGeNET Curated 9.404E-3 4.524E-2
2.607E-1
1.000E0
 1 17
36 C0011880 Diabetic Ketoacidosis DisGeNET Curated 9.404E-3 4.524E-2
2.607E-1
1.000E0
 1 17
37 C0236788 Bipolar II disorder DisGeNET Curated 9.404E-3 4.524E-2
2.607E-1
1.000E0
 1 17
38 C0431109 Choroid Plexus Carcinoma DisGeNET Curated 9.955E-3 4.663E-2
2.687E-1
1.000E0
 1 18
39 C1857451 Acth-Independent Macronodular Adrenal Hyperplasia DisGeNET Curated 1.051E-2 4.737E-2
2.729E-1
1.000E0
 1 19
40 C0008497 Choriocarcinoma DisGeNET BeFree 1.064E-2 4.737E-2
2.729E-1
1.000E0
 2 291
41 C0018799 Heart Diseases DisGeNET Curated 1.100E-2 4.775E-2
2.751E-1
1.000E0
 2 296
42 C0271650 Impaired glucose tolerance DisGeNET Curated 1.150E-2 4.804E-2
2.768E-1
1.000E0
 2 303
43 C0020545 Hypertension, Renovascular DisGeNET Curated 1.161E-2 4.804E-2
2.768E-1
1.000E0
 1 21
Show 38 more annotations