Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc189_14, positive side

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1: GO: Molecular Function [Display Chart] 14 input genes in category / 168 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042054 histone methyltransferase activity 1.802E-17 3.027E-15 1.727E-14 3.027E-15 8 59
2 GO:0018024 histone-lysine N-methyltransferase activity 1.161E-15 9.754E-14 5.564E-13 1.951E-13 7 46
3 GO:0016279 protein-lysine N-methyltransferase activity 7.685E-15 3.451E-13 1.969E-12 1.291E-12 8 122
4 GO:0016278 lysine N-methyltransferase activity 8.217E-15 3.451E-13 1.969E-12 1.380E-12 8 123
5 GO:0008170 N-methyltransferase activity 2.512E-14 7.453E-13 4.251E-12 4.221E-12 8 141
6 GO:0008276 protein methyltransferase activity 2.662E-14 7.453E-13 4.251E-12 4.472E-12 8 142
7 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1.916E-13 4.599E-12 2.623E-11 3.219E-11 8 181
8 GO:0008168 methyltransferase activity 7.152E-13 1.502E-11 8.567E-11 1.202E-10 8 213
9 GO:0016741 transferase activity, transferring one-carbon groups 1.113E-12 2.077E-11 1.185E-10 1.870E-10 8 225
10 GO:0004402 histone acetyltransferase activity 1.122E-5 1.801E-4 1.027E-3 1.884E-3 3 60
11 GO:0061733 peptide-lysine-N-acetyltransferase activity 1.179E-5 1.801E-4 1.027E-3 1.981E-3 3 61
12 GO:0034212 peptide N-acetyltransferase activity 1.710E-5 2.101E-4 1.198E-3 2.874E-3 3 69
13 GO:0043996 histone acetyltransferase activity (H4-K8 specific) 1.876E-5 2.101E-4 1.198E-3 3.152E-3 2 9
14 GO:0046972 histone acetyltransferase activity (H4-K16 specific) 1.876E-5 2.101E-4 1.198E-3 3.152E-3 2 9
15 GO:0043995 histone acetyltransferase activity (H4-K5 specific) 1.876E-5 2.101E-4 1.198E-3 3.152E-3 2 9
16 GO:0008080 N-acetyltransferase activity 6.196E-5 6.161E-4 3.514E-3 1.041E-2 3 106
17 GO:0010485 H4 histone acetyltransferase activity 6.234E-5 6.161E-4 3.514E-3 1.047E-2 2 16
18 GO:0016410 N-acyltransferase activity 9.415E-5 8.278E-4 4.722E-3 1.582E-2 3 122
19 GO:0016407 acetyltransferase activity 9.646E-5 8.278E-4 4.722E-3 1.621E-2 3 123
20 GO:0042800 histone methyltransferase activity (H3-K4 specific) 9.854E-5 8.278E-4 4.722E-3 1.656E-2 2 20
21 GO:0042393 histone binding 2.971E-4 2.377E-3 1.356E-2 4.991E-2 3 180
22 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups 5.274E-4 4.028E-3 2.298E-2
8.861E-2
 3 219
23 GO:0003714 transcription corepressor activity 6.477E-4 4.731E-3 2.699E-2
1.088E-1
 3 235
24 GO:0035064 methylated histone binding 7.314E-4 5.042E-3 2.876E-2
1.229E-1
 2 54
25 GO:0031151 histone methyltransferase activity (H3-K79 specific) 7.502E-4 5.042E-3 2.876E-2
1.260E-1
 1 1
26 GO:0016746 transferase activity, transferring acyl groups 8.399E-4 5.427E-3 3.096E-2
1.411E-1
 3 257
27 GO:0019888 protein phosphatase regulator activity 1.443E-3 8.979E-3
5.122E-2
2.424E-1
 2 76
28 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity 1.500E-3 9.000E-3
5.134E-2
2.520E-1
 1 2
29 GO:0019208 phosphatase regulator activity 1.928E-3 1.117E-2
6.372E-2
3.240E-1
 2 88
30 GO:0044020 histone methyltransferase activity (H4-R3 specific) 2.998E-3 1.625E-2
9.267E-2
5.036E-1
 1 4
31 GO:0000403 Y-form DNA binding 2.998E-3 1.625E-2
9.267E-2
5.036E-1
 1 4
32 GO:0001046 core promoter sequence-specific DNA binding 3.264E-3 1.714E-2
9.775E-2
5.484E-1
 2 115
33 GO:0046976 histone methyltransferase activity (H3-K27 specific) 3.746E-3 1.907E-2
1.088E-1
6.293E-1
 1 5
34 GO:0072542 protein phosphatase activator activity 5.987E-3 2.874E-2
1.639E-1
1.000E0
 1 8
35 GO:0008469 histone-arginine N-methyltransferase activity 5.987E-3 2.874E-2
1.639E-1
1.000E0
 1 8
36 GO:0001047 core promoter binding 6.518E-3 3.042E-2
1.735E-1
1.000E0
 2 164
37 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding 7.479E-3 3.396E-2
1.937E-1
1.000E0
 1 10
38 GO:0019211 phosphatase activator activity 8.224E-3 3.636E-2
2.074E-1
1.000E0
 1 11
39 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 9.712E-3 4.184E-2
2.386E-1
1.000E0
 1 13
40 GO:0044213 intronic transcription regulatory region DNA binding 1.046E-2 4.391E-2
2.505E-1
1.000E0
 1 14
41 GO:0070742 C2H2 zinc finger domain binding 1.194E-2 4.464E-2
2.546E-1
1.000E0
 1 16
42 GO:0000400 four-way junction DNA binding 1.194E-2 4.464E-2
2.546E-1
1.000E0
 1 16
43 GO:0000993 RNA polymerase II complex binding 1.417E-2 4.464E-2
2.546E-1
1.000E0
 1 19
44 GO:0008327 methyl-CpG binding 1.638E-2 4.464E-2
2.546E-1
1.000E0
 1 22
45 GO:0008157 protein phosphatase 1 binding 1.638E-2 4.464E-2
2.546E-1
1.000E0
 1 22
46 GO:0032442 phenylcoumaran benzylic ether reductase activity 1.712E-2 4.464E-2
2.546E-1
1.000E0
 1 23
47 GO:0044103 L-arabinose 1-dehydrogenase (NADP+) activity 1.712E-2 4.464E-2
2.546E-1
1.000E0
 1 23
48 GO:0034840 3-hydroxymenthone dehydrogenase activity 1.712E-2 4.464E-2
2.546E-1
1.000E0
 1 23
49 GO:0052677 D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity 1.712E-2 4.464E-2
2.546E-1
1.000E0
 1 23
50 GO:0008875 gluconate dehydrogenase activity 1.712E-2 4.464E-2
2.546E-1
1.000E0
 1 23
Show 45 more annotations

2: GO: Biological Process [Display Chart] 14 input genes in category / 520 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016570 histone modification 2.755E-18 1.068E-15 7.295E-15 1.432E-15 12 447
2 GO:0016569 covalent chromatin modification 4.107E-18 1.068E-15 7.295E-15 2.136E-15 12 462
3 GO:0018205 peptidyl-lysine modification 2.703E-16 4.686E-14 3.201E-13 1.406E-13 11 426
4 GO:0016571 histone methylation 1.901E-14 2.472E-12 1.689E-11 9.887E-12 8 136
5 GO:0008213 protein alkylation 1.414E-13 1.226E-11 8.374E-11 7.355E-11 8 174
6 GO:0006479 protein methylation 1.414E-13 1.226E-11 8.374E-11 7.355E-11 8 174
7 GO:0034968 histone lysine methylation 6.422E-13 4.771E-11 3.259E-10 3.340E-10 7 109
8 GO:0018022 peptidyl-lysine methylation 1.203E-12 7.822E-11 5.344E-10 6.258E-10 7 119
9 GO:0043414 macromolecule methylation 5.358E-12 3.096E-10 2.115E-9 2.786E-9 8 273
10 GO:0032259 methylation 3.824E-11 1.989E-9 1.359E-8 1.989E-8 8 349
11 GO:0016573 histone acetylation 7.522E-8 3.556E-6 2.429E-5 3.912E-5 5 157
12 GO:0018393 internal peptidyl-lysine acetylation 8.799E-8 3.813E-6 2.605E-5 4.575E-5 5 162
13 GO:0006475 internal protein amino acid acetylation 1.055E-7 4.037E-6 2.758E-5 5.487E-5 5 168
14 GO:0018394 peptidyl-lysine acetylation 1.087E-7 4.037E-6 2.758E-5 5.652E-5 5 169
15 GO:0006473 protein acetylation 2.161E-7 7.493E-6 5.119E-5 1.124E-4 5 194
16 GO:0043543 protein acylation 4.611E-7 1.499E-5 1.024E-4 2.398E-4 5 226
17 GO:0043967 histone H4 acetylation 1.371E-5 4.195E-4 2.866E-3 7.132E-3 3 64
18 GO:0043982 histone H4-K8 acetylation 5.480E-5 1.500E-3 1.025E-2 2.849E-2 2 15
19 GO:0043981 histone H4-K5 acetylation 5.480E-5 1.500E-3 1.025E-2 2.849E-2 2 15
20 GO:0035067 negative regulation of histone acetylation 6.260E-5 1.628E-3 1.112E-2 3.255E-2 2 16
21 GO:2000757 negative regulation of peptidyl-lysine acetylation 9.894E-5 2.450E-3 1.674E-2
5.145E-2
 2 20
22 GO:1901984 negative regulation of protein acetylation 1.316E-4 3.110E-3 2.125E-2
6.842E-2
 2 23
23 GO:0097421 liver regeneration 1.435E-4 3.244E-3 2.216E-2
7.461E-2
 2 24
24 GO:0031056 regulation of histone modification 1.580E-4 3.424E-3 2.339E-2
8.217E-2
 3 145
25 GO:0043984 histone H4-K16 acetylation 1.688E-4 3.511E-3 2.399E-2
8.778E-2
 2 26
26 GO:1902275 regulation of chromatin organization 2.440E-4 4.880E-3 3.334E-2
1.269E-1
 3 168
27 GO:0031057 negative regulation of histone modification 4.232E-4 8.150E-3
5.568E-2
2.201E-1
 2 41
28 GO:1904837 beta-catenin-TCF complex assembly 4.876E-4 8.884E-3
6.070E-2
2.535E-1
 2 44
29 GO:0051568 histone H3-K4 methylation 7.344E-4 8.884E-3
6.070E-2
3.819E-1
 2 54
30 GO:1904992 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
31 GO:1904311 response to gold(3+) 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
32 GO:1904313 response to methamphetamine hydrochloride 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
33 GO:1904990 regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
34 GO:1904309 response to cordycepin 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
35 GO:1904314 cellular response to methamphetamine hydrochloride 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
36 GO:1903916 regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
37 GO:0036497 eIF2alpha dephosphorylation in response to endoplasmic reticulum stress 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
38 GO:1904308 cellular response to desipramine 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
39 GO:1904312 cellular response to gold(3+) 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
40 GO:0090648 response to environmental enrichment 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
41 GO:1904307 response to desipramine 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
42 GO:1904310 cellular response to cordycepin 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
43 GO:0072732 cellular response to calcium ion starvation 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
44 GO:1903917 positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation 7.518E-4 8.884E-3
6.070E-2
3.909E-1
 1 1
45 GO:0035065 regulation of histone acetylation 7.897E-4 9.125E-3
6.234E-2
4.106E-1
 2 56
46 GO:2000756 regulation of peptidyl-lysine acetylation 9.672E-4 1.093E-2
7.469E-2
5.029E-1
 2 62
47 GO:0043966 histone H3 acetylation 1.095E-3 1.212E-2
8.278E-2
5.695E-1
 2 66
48 GO:0043666 regulation of phosphoprotein phosphatase activity 1.128E-3 1.222E-2
8.352E-2
5.868E-1
 2 67
49 GO:1901983 regulation of protein acetylation 1.162E-3 1.233E-2
8.425E-2
6.043E-1
 2 68
50 GO:0033044 regulation of chromosome organization 1.333E-3 1.261E-2
8.612E-2
6.933E-1
 3 301
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 14 input genes in category / 47 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035097 histone methyltransferase complex 3.022E-14 1.420E-12 6.302E-12 1.420E-12 7 73
2 GO:0034708 methyltransferase complex 1.615E-13 3.794E-12 1.684E-11 7.589E-12 7 92
3 GO:0071339 MLL1 complex 3.690E-9 4.336E-8 1.924E-7 1.734E-7 4 28
4 GO:0044665 MLL1/2 complex 3.690E-9 4.336E-8 1.924E-7 1.734E-7 4 28
5 GO:0048188 Set1C/COMPASS complex 5.186E-8 4.875E-7 2.164E-6 2.438E-6 3 11
6 GO:0044666 MLL3/4 complex 1.798E-5 1.409E-4 6.251E-4 8.451E-4 2 9
7 GO:0000123 histone acetyltransferase complex 3.451E-5 2.317E-4 1.028E-3 1.622E-3 3 89
8 GO:0031248 protein acetyltransferase complex 4.890E-5 2.554E-4 1.133E-3 2.298E-3 3 100
9 GO:1902493 acetyltransferase complex 4.890E-5 2.554E-4 1.133E-3 2.298E-3 3 100
10 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex 5.976E-5 2.809E-4 1.247E-3 2.809E-3 2 16
11 GO:0070461 SAGA-type complex 2.773E-4 1.185E-3 5.258E-3 1.303E-2 2 34
12 GO:0017053 transcriptional repressor complex 1.494E-3 5.853E-3 2.598E-2
7.024E-2
 2 79
13 GO:0070761 pre-snoRNP complex 4.399E-3 1.477E-2
6.555E-2
2.068E-1
 1 6
14 GO:0000125 PCAF complex 4.399E-3 1.477E-2
6.555E-2
2.068E-1
 1 6
15 GO:0034709 methylosome 8.781E-3 2.673E-2
1.186E-1
4.127E-1
 1 12
16 GO:0000164 protein phosphatase type 1 complex 9.509E-3 2.673E-2
1.186E-1
4.469E-1
 1 13
17 GO:0033276 transcription factor TFTC complex 1.024E-2 2.673E-2
1.186E-1
4.812E-1
 1 14
18 GO:0030914 STAGA complex 1.024E-2 2.673E-2
1.186E-1
4.812E-1
 1 14
19 GO:0000176 nuclear exosome (RNase complex) 1.096E-2 2.712E-2
1.204E-1
5.153E-1
 1 15
20 GO:0035098 ESC/E(Z) complex 1.169E-2 2.748E-2
1.219E-1
5.495E-1
 1 16
21 GO:0000178 exosome (RNase complex) 1.532E-2 3.429E-2
1.522E-1
7.200E-1
 1 21
22 GO:0005669 transcription factor TFIID complex 1.677E-2 3.582E-2
1.590E-1
7.880E-1
 1 23
Show 17 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 370 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012051 Reactive hypoglycemia 8.497E-4 3.555E-2
2.308E-1
3.144E-1
 1 2
2 HP:0100844 Pancreatic fistula 8.497E-4 3.555E-2
2.308E-1
3.144E-1
 1 2
3 HP:0030404 Glucagonoma 8.497E-4 3.555E-2
2.308E-1
3.144E-1
 1 2
4 HP:0007942 Internal ophthalmoplegia 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
5 HP:0005017 Polyarticular chondrocalcinosis 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
6 HP:0030688 Increased glucagon level 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
7 HP:0030687 Abnormal glucagon level 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
8 HP:0012334 Extrahepatic cholestasis 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
9 HP:0007011 Fourth cranial nerve palsy 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
10 HP:0012197 Insulinoma 1.274E-3 3.555E-2
2.308E-1
4.715E-1
 1 3
11 HP:0030018 Decreased female libido 1.699E-3 3.555E-2
2.308E-1
6.287E-1
 1 4
12 HP:0007159 Fluctuations in consciousness 1.699E-3 3.555E-2
2.308E-1
6.287E-1
 1 4
13 HP:0012029 Abnormality of urine hormone level 2.124E-3 3.555E-2
2.308E-1
7.857E-1
 1 5
14 HP:0040278 Prolactinoma 2.124E-3 3.555E-2
2.308E-1
7.857E-1
 1 5
15 HP:0012030 Increased urinary cortisol level 2.124E-3 3.555E-2
2.308E-1
7.857E-1
 1 5
16 HP:0007449 Confetti-like hypopigmented macules 2.124E-3 3.555E-2
2.308E-1
7.857E-1
 1 5
17 HP:0011735 Adrenocorticotropin deficient adrenal insufficiency 2.124E-3 3.555E-2
2.308E-1
7.857E-1
 1 5
18 HP:0006277 Pancreatic hyperplasia 2.548E-3 3.555E-2
2.308E-1
9.428E-1
 1 6
19 HP:0031094 Abnormal breast physiology 2.548E-3 3.555E-2
2.308E-1
9.428E-1
 1 6
20 HP:0100829 Galactorrhea 2.548E-3 3.555E-2
2.308E-1
9.428E-1
 1 6
21 HP:0030517 Heteronymous hemianopia 2.548E-3 3.555E-2
2.308E-1
9.428E-1
 1 6
22 HP:0030521 Bitemporal hemianopia 2.548E-3 3.555E-2
2.308E-1
9.428E-1
 1 6
23 HP:0012072 Aciduria 2.833E-3 3.555E-2
2.308E-1
1.000E0
 2 251
24 HP:0008240 Secondary growth hormone deficiency 2.972E-3 3.555E-2
2.308E-1
1.000E0
 1 7
25 HP:0001958 Nonketotic hypoglycemia 2.972E-3 3.555E-2
2.308E-1
1.000E0
 1 7
26 HP:0009719 Hypomelanotic macule 2.972E-3 3.555E-2
2.308E-1
1.000E0
 1 7
27 HP:0010639 Elevated alkaline phosphatase of bone origin 2.972E-3 3.555E-2
2.308E-1
1.000E0
 1 7
28 HP:0008283 Fasting hyperinsulinemia 2.972E-3 3.555E-2
2.308E-1
1.000E0
 1 7
29 HP:0100962 Shyness 3.397E-3 3.555E-2
2.308E-1
1.000E0
 1 8
30 HP:0011763 Pituitary carcinoma 3.397E-3 3.555E-2
2.308E-1
1.000E0
 1 8
31 HP:0006897 Cranial nerve VI palsy 3.397E-3 3.555E-2
2.308E-1
1.000E0
 1 8
32 HP:0001031 Subcutaneous lipoma 3.821E-3 3.555E-2
2.308E-1
1.000E0
 1 9
33 HP:0002494 Abnormal rapid eye movement sleep 3.821E-3 3.555E-2
2.308E-1
1.000E0
 1 9
34 HP:0006723 Intestinal carcinoid 3.821E-3 3.555E-2
2.308E-1
1.000E0
 1 9
35 HP:0011760 Pituitary growth hormone cell adenoma 3.821E-3 3.555E-2
2.308E-1
1.000E0
 1 9
36 HP:0005206 Pancreatic pseudocyst 3.821E-3 3.555E-2
2.308E-1
1.000E0
 1 9
37 HP:0008291 Pituitary corticotropic cell adenoma 4.245E-3 3.555E-2
2.308E-1
1.000E0
 1 10
38 HP:0006279 Beta-cell dysfunction 4.245E-3 3.555E-2
2.308E-1
1.000E0
 1 10
39 HP:0008261 Pancreatic islet cell adenoma 4.245E-3 3.555E-2
2.308E-1
1.000E0
 1 10
40 HP:0030405 Pancreatic endocrine tumor 4.245E-3 3.555E-2
2.308E-1
1.000E0
 1 10
41 HP:0011761 Pituitary null cell adenoma 4.245E-3 3.555E-2
2.308E-1
1.000E0
 1 10
42 HP:0010534 Transient global amnesia 4.245E-3 3.555E-2
2.308E-1
1.000E0
 1 10
43 HP:0008208 Parathyroid hyperplasia 4.669E-3 3.555E-2
2.308E-1
1.000E0
 1 11
44 HP:0006767 Pituitary prolactin cell adenoma 4.669E-3 3.555E-2
2.308E-1
1.000E0
 1 11
45 HP:0001117 Sudden loss of visual acuity 4.669E-3 3.555E-2
2.308E-1
1.000E0
 1 11
46 HP:0100567 Endocrine pancreatic insufficiency 4.669E-3 3.555E-2
2.308E-1
1.000E0
 1 11
47 HP:0004382 Mitral valve calcification 5.093E-3 3.555E-2
2.308E-1
1.000E0
 1 12
48 HP:0004380 Aortic valve calcification 5.093E-3 3.555E-2
2.308E-1
1.000E0
 1 12
49 HP:0008250 Infantile hypercalcemia 5.093E-3 3.555E-2
2.308E-1
1.000E0
 1 12
50 HP:0003118 Increased circulating cortisol level 5.093E-3 3.555E-2
2.308E-1
1.000E0
 1 12
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 328 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 14 input genes in category / 86 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00856 SET Pfam 3.482E-6 1.371E-4 6.907E-4 2.995E-4 3 41
2 SM00317 SET SMART 4.948E-6 1.371E-4 6.907E-4 4.255E-4 3 46
3 PS50280 SET PROSITE 6.377E-6 1.371E-4 6.907E-4 5.484E-4 3 50
4 IPR001214 SET dom InterPro 6.377E-6 1.371E-4 6.907E-4 5.484E-4 3 50
5 IPR032926 EZH1 InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
6 IPR025805 Hist-Lys N-MeTrfase Smyd3 InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
7 IPR021169 DOT1L/grappa InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
8 IPR011082 Exosome-assoc fac/DNA repair InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
9 IPR009170 RIZ retinblastoma-bd prot InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
10 IPR007747 Menin InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
11 PS51569 DOT1 PROSITE 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
12 IPR030445 H3-K79 meTrfase InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
13 IPR025789 DOT1 dom InterPro 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
14 PS51574 SAM MT43 2 PROSITE 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
15 PF05053 Menin Pfam 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
16 PF08123 DOT1 Pfam 7.473E-4 4.017E-3 2.023E-2
6.426E-2
 1 1
17 PS51633 CXC PROSITE 1.494E-3 5.840E-3 2.942E-2
1.285E-1
 1 2
18 PF11616 EZH2 WD-Binding Pfam 1.494E-3 5.840E-3 2.942E-2
1.285E-1
 1 2
19 IPR026489 CXC dom InterPro 1.494E-3 5.840E-3 2.942E-2
1.285E-1
 1 2
20 PF10488 PP1c bdg Pfam 1.494E-3 5.840E-3 2.942E-2
1.285E-1
 1 2
21 IPR019523 Prot Pase1 reg-su15A/B C InterPro 1.494E-3 5.840E-3 2.942E-2
1.285E-1
 1 2
22 IPR021654 EZH1/EZH2 InterPro 1.494E-3 5.840E-3 2.942E-2
1.285E-1
 1 2
23 IPR003162 TFIID-31 InterPro 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
24 IPR007146 Sas10/Utp3/C1D InterPro 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
25 PF05185 PRMT5 Pfam 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
26 PF04000 Sas10 Utp3 Pfam 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
27 PF02291 TFIID-31kDa Pfam 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
28 IPR029752 D-isomer DH CS1 InterPro 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
29 IPR007857 Arg MeTrfase PRMT5 InterPro 2.240E-3 6.643E-3 3.347E-2
1.927E-1
 1 3
30 IPR029753 D-isomer DH CS InterPro 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
31 PS00065 D 2 HYDROXYACID DH 1 PROSITE 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
32 PF02826 2-Hacid dh C Pfam 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
33 PS00671 D 2 HYDROXYACID DH 3 PROSITE 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
34 PS00670 D 2 HYDROXYACID DH 2 PROSITE 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
35 IPR006139 D-isomer 2 OHA DH cat dom InterPro 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
36 PF00389 2-Hacid dh Pfam 2.986E-3 7.133E-3 3.593E-2
2.568E-1
 1 4
37 3.40.50.150 - Gene3D 3.521E-3 8.183E-3 4.122E-2
3.028E-1
 2 120
38 IPR029063 SAM-dependent MTases InterPro 3.636E-3 8.228E-3 4.145E-2
3.127E-1
 2 122
39 IPR006140 D-isomer DH NAD-bd InterPro 3.731E-3 8.228E-3 4.145E-2
3.209E-1
 1 5
40 IPR033467 Tesmin/TSO1-like CXC InterPro 4.476E-3 9.388E-3 4.729E-2
3.849E-1
 1 6
41 SM01114 CXC SMART 4.476E-3 9.388E-3 4.729E-2
3.849E-1
 1 6
42 IPR025799 Arg MeTrfase InterPro 6.707E-3 1.341E-2
6.757E-2
5.768E-1
 1 9
43 PS51678 SAM MT PRMT PROSITE 6.707E-3 1.341E-2
6.757E-2
5.768E-1
 1 9
44 IPR001632 Gprotein B InterPro 7.449E-3 1.456E-2
7.334E-2
6.406E-1
 1 10
45 IPR011498 Kelch 2 InterPro 9.674E-3 1.809E-2
9.111E-2
8.320E-1
 1 13
46 PF07646 Kelch 2 Pfam 9.674E-3 1.809E-2
9.111E-2
8.320E-1
 1 13
47 PF02178 AT hook Pfam 1.189E-2 2.176E-2
1.096E-1
1.000E0
 1 16
48 IPR002164 NAP family InterPro 1.263E-2 2.217E-2
1.117E-1
1.000E0
 1 17
49 PF00956 NAP Pfam 1.263E-2 2.217E-2
1.117E-1
1.000E0
 1 17
50 PF00400 WD40 Pfam 1.553E-2 2.590E-2
1.305E-1
1.000E0
 2 259
Show 45 more annotations

7: Pathway [Display Chart] 14 input genes in category / 92 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270433 Chromatin organization BioSystems: REACTOME 7.902E-9 3.635E-7 1.855E-6 7.269E-7 7 279
2 1270434 Chromatin modifying enzymes BioSystems: REACTOME 7.902E-9 3.635E-7 1.855E-6 7.269E-7 7 279
3 1270438 PKMTs methylate histone lysines BioSystems: REACTOME 1.042E-6 3.194E-5 1.630E-4 9.582E-5 4 73
4 1269604 Deactivation of the beta-catenin transactivating complex BioSystems: REACTOME 1.360E-5 3.129E-4 1.597E-3 1.252E-3 3 43
5 82956 Lysine degradation BioSystems: KEGG 3.546E-5 6.524E-4 3.330E-3 3.262E-3 3 59
6 PW:0000398 homocysteine metabolic Pathway Ontology 1.778E-4 2.727E-3 1.392E-2 1.636E-2 2 18
7 PW:0000048 methionine cycle/metabolic Pathway Ontology 3.471E-4 4.562E-3 2.329E-2 3.193E-2 2 25
8 1270435 HATs acetylate histones BioSystems: REACTOME 4.922E-4 5.661E-3 2.889E-2 4.529E-2 3 143
9 1269599 TCF dependent signaling in response to WNT BioSystems: REACTOME 2.253E-3 2.303E-2
1.176E-1
2.073E-1
 3 242
10 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 3.274E-3 2.640E-2
1.348E-1
3.012E-1
 2 77
11 1268922 TCF7L2 mutants don't bind CTBP BioSystems: REACTOME 3.370E-3 2.640E-2
1.348E-1
3.100E-1
 1 3
12 1270439 RMTs methylate histone arginines BioSystems: REACTOME 3.443E-3 2.640E-2
1.348E-1
3.168E-1
 2 79
13 1269602 Formation of the beta-catenin:TCF transactivating complex BioSystems: REACTOME 4.639E-3 3.283E-2
1.676E-1
4.268E-1
 2 92
14 1269594 Signaling by Wnt BioSystems: REACTOME 5.874E-3 3.860E-2
1.970E-1
5.404E-1
 3 340
15 1339139 Activation of HOX genes during differentiation BioSystems: REACTOME 8.671E-3 4.851E-2
2.476E-1
7.977E-1
 2 127
16 1339140 Activation of anterior HOX genes in hindbrain development during early embryogenesis BioSystems: REACTOME 8.671E-3 4.851E-2
2.476E-1
7.977E-1
 2 127
17 1269730 HuR (ELAVL1) binds and stabilizes mRNA BioSystems: REACTOME 8.963E-3 4.851E-2
2.476E-1
8.246E-1
 1 8
Show 12 more annotations

8: Pubmed [Display Chart] 14 input genes in category / 1909 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15960975 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Pubmed 4.999E-13 9.542E-10 7.760E-9 9.542E-10 5 31
2 15199122 Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Pubmed 1.421E-12 1.357E-9 1.103E-8 2.713E-9 4 9
3 20093773 c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. Pubmed 7.836E-10 4.986E-7 4.055E-6 1.496E-6 3 6
4 19131338 Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. Pubmed 1.371E-9 6.543E-7 5.321E-6 2.617E-6 3 7
5 20362541 An Oct4-centered protein interaction network in embryonic stem cells. Pubmed 2.428E-9 9.270E-7 7.538E-6 4.635E-6 5 161
6 24930734 The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation. Pubmed 3.289E-9 1.046E-6 8.509E-6 6.279E-6 3 9
7 17998332 Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. Pubmed 4.697E-9 1.121E-6 9.115E-6 8.967E-6 3 10
8 18838538 Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Pubmed 4.697E-9 1.121E-6 9.115E-6 8.967E-6 3 10
9 17707229 Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Pubmed 6.458E-9 1.233E-6 1.002E-5 1.233E-5 3 11
10 18082152 Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Pubmed 6.458E-9 1.233E-6 1.002E-5 1.233E-5 3 11
11 27563068 Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. Pubmed 8.608E-9 1.494E-6 1.215E-5 1.643E-5 3 12
12 27705803 A High-Density Map for Navigating the Human Polycomb Complexome. Pubmed 1.265E-8 2.012E-6 1.636E-5 2.414E-5 6 495
13 14992727 Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Pubmed 1.424E-8 2.091E-6 1.700E-5 2.718E-5 3 14
14 16510875 Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Pubmed 1.779E-8 2.264E-6 1.841E-5 3.396E-5 3 15
15 17925232 The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Pubmed 1.779E-8 2.264E-6 1.841E-5 3.396E-5 3 15
16 23870121 SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Pubmed 2.189E-8 2.612E-6 2.124E-5 4.179E-5 3 16
17 21653943 Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Pubmed 2.658E-8 2.985E-6 2.427E-5 5.074E-5 3 17
18 17846119 USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Pubmed 3.189E-8 3.204E-6 2.605E-5 6.087E-5 3 18
19 17500065 PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. Pubmed 3.189E-8 3.204E-6 2.605E-5 6.087E-5 3 18
20 24993551 Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma. Pubmed 1.248E-7 1.134E-5 9.223E-5 2.382E-4 2 2
21 17963297 Silencing SMYD3 in hepatoma demethylates RIZI promoter induces apoptosis and inhibits cell proliferation and migration. Pubmed 1.248E-7 1.134E-5 9.223E-5 2.382E-4 2 2
22 20516061 Identification and characterization of a novel human PP1 phosphatase complex. Pubmed 1.752E-7 1.520E-5 1.236E-4 3.344E-4 3 31
23 23892456 A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Pubmed 1.832E-7 1.520E-5 1.236E-4 3.497E-4 4 143
24 22325351 Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Pubmed 2.330E-7 1.854E-5 1.507E-4 4.449E-4 3 34
25 20716525 Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. Pubmed 3.742E-7 2.551E-5 2.075E-4 7.144E-4 2 3
26 16604156 Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. Pubmed 3.742E-7 2.551E-5 2.075E-4 7.144E-4 2 3
27 28270438 Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB. Pubmed 3.742E-7 2.551E-5 2.075E-4 7.144E-4 2 3
28 27320920 In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Pubmed 3.742E-7 2.551E-5 2.075E-4 7.144E-4 2 3
29 20064463 A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Pubmed 7.483E-7 4.202E-5 3.417E-4 1.429E-3 2 4
30 23178126 Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. Pubmed 7.483E-7 4.202E-5 3.417E-4 1.429E-3 2 4
31 26927674 MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. Pubmed 7.483E-7 4.202E-5 3.417E-4 1.429E-3 2 4
32 21220120 Structural and biochemical insights into MLL1 core complex assembly. Pubmed 7.483E-7 4.202E-5 3.417E-4 1.429E-3 2 4
33 20085832 Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8. Pubmed 7.483E-7 4.202E-5 3.417E-4 1.429E-3 2 4
34 21477851 Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Pubmed 7.483E-7 4.202E-5 3.417E-4 1.429E-3 2 4
35 17296600 Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Pubmed 9.618E-7 5.175E-5 4.208E-4 1.836E-3 3 54
36 21884981 Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
37 24680668 A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
38 16603732 Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
39 24491801 UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
40 21124902 An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
41 21285357 Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
42 21670200 Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
43 18026121 p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
44 19556245 On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
45 17050672 Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
46 28182322 Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Pubmed 1.247E-6 5.175E-5 4.208E-4 2.380E-3 2 5
47 20305087 A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Pubmed 1.393E-6 5.660E-5 4.602E-4 2.660E-3 3 61
48 24705355 CHARGE and Kabuki syndromes: a phenotypic and molecular link. Pubmed 1.870E-6 7.285E-5 5.924E-4 3.570E-3 2 6
49 24235145 Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation. Pubmed 1.870E-6 7.285E-5 5.924E-4 3.570E-3 2 6
50 7597030 Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. Pubmed 2.617E-6 8.766E-5 7.128E-4 4.997E-3 2 7
Show 45 more annotations

9: Interaction [Display Chart] 14 input genes in category / 969 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KMT2A KMT2A interactions 2.918E-17 2.827E-14 2.107E-13 2.827E-14 9 115
2 int:HIST3H3 HIST3H3 interactions 3.454E-16 1.673E-13 1.247E-12 3.347E-13 10 258
3 int:RBBP5 RBBP5 interactions 5.861E-9 1.893E-6 1.411E-5 5.679E-6 5 90
4 int:HCFC2 HCFC2 interactions 1.119E-8 2.712E-6 2.021E-5 1.085E-5 4 34
5 int:HIST4H4 HIST4H4 interactions 1.772E-8 3.435E-6 2.560E-5 1.717E-5 5 112
6 int:HCFC1 HCFC1 interactions 2.305E-8 3.723E-6 2.775E-5 2.234E-5 5 118
7 int:CXXC1 CXXC1 interactions 5.519E-8 7.640E-6 5.695E-5 5.348E-5 4 50
8 int:ZNF335 ZNF335 interactions 2.191E-7 2.654E-5 1.979E-4 2.124E-4 3 16
9 int:MEN1 MEN1 interactions 2.581E-7 2.779E-5 2.072E-4 2.501E-4 4 73
10 int:ASH2L ASH2L interactions 3.931E-7 3.621E-5 2.699E-4 3.810E-4 4 81
11 int:WDR5 WDR5 interactions 4.110E-7 3.621E-5 2.699E-4 3.983E-4 5 210
12 int:SIN3A SIN3A interactions 6.732E-7 5.436E-5 4.052E-4 6.523E-4 5 232
13 int:KDM6B KDM6B interactions 7.891E-7 5.882E-5 4.384E-4 7.647E-4 3 24
14 int:NANOG NANOG interactions 9.155E-7 6.337E-5 4.723E-4 8.871E-4 6 476
15 int:RUNX1 RUNX1 interactions 1.783E-6 1.152E-4 8.587E-4 1.728E-3 4 118
16 int:HIST1H3A HIST1H3A interactions 3.176E-6 1.924E-4 1.434E-3 3.078E-3 5 318
17 int:MEF2D MEF2D interactions 4.123E-6 2.264E-4 1.687E-3 3.995E-3 3 41
18 int:KDM2B KDM2B interactions 4.438E-6 2.264E-4 1.687E-3 4.301E-3 3 42
19 int:SETD1A SETD1A interactions 4.438E-6 2.264E-4 1.687E-3 4.301E-3 3 42
20 int:KAT8 KAT8 interactions 6.254E-6 3.030E-4 2.259E-3 6.061E-3 3 47
21 int:KMT2D KMT2D interactions 6.668E-6 3.077E-4 2.294E-3 6.462E-3 3 48
22 int:ESRRB ESRRB interactions 9.556E-6 4.209E-4 3.137E-3 9.260E-3 4 180
23 int:MYB MYB interactions 1.520E-5 6.286E-4 4.685E-3 1.473E-2 3 63
24 int:DPY30 DPY30 interactions 1.594E-5 6.286E-4 4.685E-3 1.545E-2 3 64
25 int:NFE4 NFE4 interactions 1.622E-5 6.286E-4 4.685E-3 1.571E-2 2 8
26 int:PHF8 PHF8 interactions 1.749E-5 6.520E-4 4.860E-3 1.695E-2 3 66
27 int:WDR82 WDR82 interactions 1.831E-5 6.570E-4 4.897E-3 1.774E-2 3 67
28 int:USF1 USF1 interactions 2.000E-5 6.923E-4 5.160E-3 1.938E-2 3 69
29 int:NFE2 NFE2 interactions 3.743E-5 1.209E-3 9.011E-3 3.627E-2 3 85
30 int:NCOA6 NCOA6 interactions 3.743E-5 1.209E-3 9.011E-3 3.627E-2 3 85
31 int:ASCL2 ASCL2 interactions 4.508E-5 1.402E-3 1.045E-2 4.368E-2 2 13
32 int:TERF2 TERF2 interactions 4.629E-5 1.402E-3 1.045E-2 4.485E-2 4 269
33 int:PRDM2 PRDM2 interactions 5.256E-5 1.543E-3 1.151E-2
5.093E-2
 2 14
34 int:CSNK2A2 CSNK2A2 interactions 5.563E-5 1.585E-3 1.182E-2
5.391E-2
 4 282
35 int:FOXK1 FOXK1 interactions 6.085E-5 1.685E-3 1.256E-2
5.896E-2
 3 100
36 int:EIF2S1 EIF2S1 interactions 6.455E-5 1.737E-3 1.295E-2
6.255E-2
 3 102
37 int:PAGR1 PAGR1 interactions 8.822E-5 2.310E-3 1.722E-2
8.548E-2
 2 18
38 int:MAFA MAFA interactions 9.855E-5 2.513E-3 1.873E-2
9.550E-2
 2 19
39 int:SNRPN SNRPN interactions 1.073E-4 2.651E-3 1.976E-2
1.040E-1
 3 121
40 int:PYGO2 PYGO2 interactions 1.095E-4 2.651E-3 1.976E-2
1.061E-1
 2 20
41 int:SETD1B SETD1B interactions 1.209E-4 2.727E-3 2.033E-2
1.172E-1
 2 21
42 int:PHF20 PHF20 interactions 1.209E-4 2.727E-3 2.033E-2
1.172E-1
 2 21
43 int:SENP3 SENP3 interactions 1.210E-4 2.727E-3 2.033E-2
1.173E-1
 3 126
44 int:KAT2A KAT2A interactions 1.358E-4 2.922E-3 2.178E-2
1.316E-1
 3 131
45 int:CARM1 CARM1 interactions 1.358E-4 2.922E-3 2.178E-2
1.316E-1
 3 131
46 int:HDAC5 HDAC5 interactions 1.387E-4 2.922E-3 2.178E-2
1.344E-1
 4 357
47 int:OGT OGT interactions 1.724E-4 3.350E-3 2.497E-2
1.670E-1
 3 142
48 int:H3F3C H3F3C interactions 1.724E-4 3.350E-3 2.497E-2
1.671E-1
 2 25
49 int:EZH1 EZH1 interactions 1.724E-4 3.350E-3 2.497E-2
1.671E-1
 2 25
50 int:HDAC2 HDAC2 interactions 1.728E-4 3.350E-3 2.497E-2
1.675E-1
 4 378
Show 45 more annotations

10: Cytoband [Display Chart] 14 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9q34 9q34 2.142E-4 2.625E-3 8.349E-3 2.785E-3 2 54
2 5q11.2-q13.1 5q11.2-q13.1 4.039E-4 2.625E-3 8.349E-3 5.251E-3 1 1
3 17q21.1-q21.3 17q21.1-q21.3 8.077E-4 3.500E-3 1.113E-2 1.050E-2 1 2
4 2p13-p12 2p13-p12 1.615E-3 5.248E-3 1.669E-2 2.099E-2 1 4
5 4p16 4p16 6.846E-3 1.780E-2
5.660E-2
8.900E-2
 1 17
6 1q32 1q32 1.961E-2 4.250E-2
1.351E-1
2.550E-1
 1 49
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 11 input genes in category / 56 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 9 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 487 Lysine methyltransferases|RNA binding motif containing genenames.org 1.272E-9 1.272E-8 3.725E-8 1.272E-8 4 34
2 1058 ATAC complex genenames.org 1.692E-5 8.459E-5 2.478E-4 1.692E-4 2 13
3 1347 Lysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2 genenames.org 2.965E-3 8.461E-3 2.478E-2 2.965E-2 1 6
4 694 Protein phosphatase 1 regulatory subunits genenames.org 3.384E-3 8.461E-3 2.478E-2 3.384E-2 2 181
5 691 Protein arginine methyltransferases genenames.org 4.444E-3 8.888E-3 2.603E-2 4.444E-2 1 9
6 362 Ring finger proteins|WD repeat domain containing genenames.org 6.957E-3 1.159E-2 3.396E-2
6.957E-2
 2 262
7 1197 Zinc fingers C2H2-type|PR/SET domain family genenames.org 8.380E-3 1.197E-2 3.506E-2
8.380E-2
 1 17
8 87 Zinc fingers MYND-type genenames.org 1.034E-2 1.293E-2 3.787E-2
1.034E-1
 1 21
9 532 GATA zinc finger domain containing|Myb/SANT domain containing genenames.org 2.592E-2 2.880E-2
8.435E-2
2.592E-1
 1 53
10 103 X-linked mental retardation|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 4.271E-2 4.271E-2
1.251E-1
4.271E-1
 1 88
Show 5 more annotations

13: Coexpression [Display Chart] 14 input genes in category / 1293 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12925741-Figure8 Human Lymphoma Jenner03 279genes GeneSigDB 9.784E-5 4.603E-2
3.564E-1
1.265E-1
 3 153
2 M9094 Genes down-regulated in CD4 T conv: control versus over-expression of XBP1 [GeneID=7494]. MSigDB C7: Immunologic Signatures (v6.0) 1.180E-4 4.603E-2
3.564E-1
1.526E-1
 3 163
3 M6234 Genes up-regulated in double negative thymocyte versus immature CD4 [GeneID=920] single positive cells. MSigDB C7: Immunologic Signatures (v6.0) 1.974E-4 4.603E-2
3.564E-1
2.552E-1
 3 194
4 M5873 Genes up-regulated in comparison of monocytes treated with 1 ng/ml LPS (TLR4 agonist) versus untreated monocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.065E-4 4.603E-2
3.564E-1
2.670E-1
 3 197
5 M5429 Genes up-regulated in comparison of mast cells versus macrophages. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 4.603E-2
3.564E-1
2.791E-1
 3 200
6 M6014 Genes down-regulated in dendritic cells: CIITA [GeneID=4261] knockout versus I ab-/- mice. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 4.603E-2
3.564E-1
2.791E-1
 3 200
7 15284076-TableE2 Human Lung not cancer Golpon04 242genes GeneSigDB 2.492E-4 4.603E-2
3.564E-1
3.222E-1
 3 210
Show 2 more annotations

14: Coexpression Atlas [Display Chart] 14 input genes in category / 648 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 12 input genes in category / 109 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16886 MORF PPP2CA Neighborhood of PPP2CA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.004E-4 2.451E-2
1.292E-1
 4.365E-2 3 127
2 M10646 GCM MSN Neighborhood of MSN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.869E-4 2.451E-2
1.292E-1
5.307E-2
 2 28
3 M6582 GCM RAD21 Neighborhood of RAD21 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.527E-4 2.451E-2
1.292E-1
9.294E-2
 2 37
4 M3292 GCM HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.994E-4 2.451E-2
1.292E-1
9.804E-2
 2 38
5 M7638 GCM RAF1 Neighborhood of RAF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.152E-3 2.510E-2
1.324E-1
1.255E-1
 2 43
6 M18997 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.355E-3 4.070E-2
2.146E-1
2.567E-1
 3 234
7 M1646 GCM DDX5 Neighborhood of DDX5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.614E-3 4.070E-2
2.146E-1
2.849E-1
 2 65
Show 2 more annotations

16: MicroRNA [Display Chart] 14 input genes in category / 543 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-541-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.669E-7 3.078E-4 2.116E-3 3.078E-4 3 85
2 hsa-miR-5681a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.392E-6 6.494E-4 4.464E-3 1.299E-3 3 137
3 hsa-miR-6756-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.398E-5 1.898E-3 1.305E-2 7.590E-3 3 247
4 hsa-miR-6766-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.398E-5 1.898E-3 1.305E-2 7.590E-3 3 247
5 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 3.715E-5 4.035E-3 2.774E-2 2.017E-2 3 343
6 hsa-miR-423-3p:mirSVR lowEffct hsa-miR-423-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.775E-5 5.226E-3 3.593E-2 3.136E-2 3 398
7 hsa-miR-1208:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.428E-5 5.417E-3 3.725E-2 4.033E-2 2 66
8 hsa-miR-668:mirSVR highEffct hsa-miR-668:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.982E-5 5.417E-3 3.725E-2 4.334E-2 3 444
9 hsa-miR-4749-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.176E-4 6.540E-3 4.497E-2
6.387E-2
 2 83
10 hsa-miR-589-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.234E-4 6.540E-3 4.497E-2
6.699E-2
 2 85
11 hsa-miR-4706:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.353E-4 6.540E-3 4.497E-2
7.345E-2
 2 89
12 hsa-miR-346:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.445E-4 6.540E-3 4.497E-2
7.848E-2
 2 92
13 hsa-miR-6751-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.883E-4 7.863E-3
5.406E-2
1.022E-1
 2 105
14 hsa-miR-6803-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.104E-4 8.159E-3
5.609E-2
1.142E-1
 2 111
15 hsa-miR-4251:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.499E-4 8.433E-3
5.798E-2
1.357E-1
 2 121
16 hsa-miR-6752-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.709E-4 8.433E-3
5.798E-2
1.471E-1
 2 126
17 hsa-miR-6804-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.709E-4 8.433E-3
5.798E-2
1.471E-1
 2 126
18 hsa-miR-502-5p:PITA hsa-miR-502-5p:PITA TOP PITA 2.795E-4 8.433E-3
5.798E-2
1.518E-1
 2 128
19 hsa-miR-1200:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.413E-4 1.261E-2
8.672E-2
2.397E-1
 2 161
20 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 6.925E-4 1.826E-2
1.255E-1
3.760E-1
 2 202
21 hsa-miR-220c:PITA hsa-miR-220c:PITA TOP PITA 7.061E-4 1.826E-2
1.255E-1
3.834E-1
 2 204
22 hsa-miR-6500-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.981E-4 1.962E-2
1.349E-1
4.334E-1
 2 217
23 TAGCTTT,MIR-9:MSigDB TAGCTTT,MIR-9:MSigDB MSigDB 8.574E-4 1.962E-2
1.349E-1
4.656E-1
 2 225
24 hsa-miR-625-5p:Functional MTI Functional MTI miRTarbase 8.726E-4 1.962E-2
1.349E-1
4.738E-1
 2 227
25 hsa-miR-766-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.033E-4 1.962E-2
1.349E-1
4.905E-1
 2 231
26 hsa-miR-145-5p:Functional MTI Functional MTI miRTarbase 9.582E-4 2.001E-2
1.376E-1
5.203E-1
 2 238
27 hsa-miR-29b-3p:Functional MTI Functional MTI miRTarbase 1.150E-3 2.312E-2
1.590E-1
6.244E-1
 2 261
28 hsa-miR-1233:mirSVR highEffct hsa-miR-1233:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.847E-3 2.900E-2
1.994E-1
1.000E0
 2 332
29 hsa-miR-501-5p:PITA hsa-miR-501-5p:PITA TOP PITA 1.936E-3 2.900E-2
1.994E-1
1.000E0
 2 340
30 hsa-miR-18a-3p:Functional MTI Functional MTI miRTarbase 2.049E-3 2.900E-2
1.994E-1
1.000E0
 2 350
31 hsa-miR-1200:PITA hsa-miR-1200:PITA TOP PITA 2.049E-3 2.900E-2
1.994E-1
1.000E0
 2 350
32 hsa-miR-572:mirSVR lowEffct hsa-miR-572:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.084E-3 2.900E-2
1.994E-1
1.000E0
 2 353
33 CTACCTC,LET-7F:MSigDB CTACCTC,LET-7F:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
34 CTACCTC,LET-7A:MSigDB CTACCTC,LET-7A:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
35 CTACCTC,LET-7C:MSigDB CTACCTC,LET-7C:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
36 CTACCTC,LET-7I:MSigDB CTACCTC,LET-7I:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
37 CTACCTC,LET-7D:MSigDB CTACCTC,LET-7D:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
38 CTACCTC,LET-7E:MSigDB CTACCTC,LET-7E:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
39 CTACCTC,MIR-98:MSigDB CTACCTC,MIR-98:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
40 CTACCTC,LET-7G:MSigDB CTACCTC,LET-7G:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
41 CTACCTC,LET-7B:MSigDB CTACCTC,LET-7B:MSigDB MSigDB 2.190E-3 2.900E-2
1.994E-1
1.000E0
 2 362
42 hsa-miR-6825-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.433E-3 3.146E-2
2.163E-1
1.000E0
 2 382
43 hsa-miR-3186-5p:mirSVR lowEffct hsa-miR-3186-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.676E-3 3.270E-2
2.248E-1
1.000E0
 2 401
44 hsa-miR-4668-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.689E-3 3.270E-2
2.248E-1
1.000E0
 2 402
45 hsa-miR-4798-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.710E-3 3.270E-2
2.248E-1
1.000E0
 1 14
46 hsa-miR-587:PITA hsa-miR-587:PITA TOP PITA 2.862E-3 3.378E-2
2.323E-1
1.000E0
 2 415
47 hsa-miR-125b-5p:Functional MTI Functional MTI miRTarbase 3.082E-3 3.560E-2
2.448E-1
1.000E0
 2 431
48 hsa-miR-450a-5p:Functional MTI Functional MTI miRTarbase 3.290E-3 3.699E-2
2.543E-1
1.000E0
 1 17
49 hsa-miR-1914:mirSVR highEffct hsa-miR-1914:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.338E-3 3.699E-2
2.543E-1
1.000E0
 2 449
50 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 3.455E-3 3.753E-2
2.580E-1
1.000E0
 2 457
Show 45 more annotations

17: Drug [Display Chart] 14 input genes in category / 3308 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000193 S-adenosyl-D-homocysteine Stitch 2.217E-9 7.335E-6 6.367E-5 7.335E-6 6 222
2 CID000003017 diazinon Stitch 3.086E-7 5.104E-4 4.431E-3 1.021E-3 4 98
3 CID000446054 In-G Stitch 1.388E-4 2.747E-2
2.385E-1
4.592E-1
 3 170
4 CID011963946 2-Formyl-Protoporphryn Ix Stitch 1.606E-4 2.747E-2
2.385E-1
5.312E-1
 2 31
5 CID000007050 MDAC Stitch 1.712E-4 2.747E-2
2.385E-1
5.664E-1
 2 32
6 1673 DN Sulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.782E-4 2.747E-2
2.385E-1
5.894E-1
 3 185
7 868 UP 5182598; Up 200; 25uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 1.839E-4 2.747E-2
2.385E-1
6.084E-1
 3 187
8 4310 DN Dipyrone [5907-38-0]; Down 200; 12uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.868E-4 2.747E-2
2.385E-1
6.181E-1
 3 188
9 4304 DN Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.898E-4 2.747E-2
2.385E-1
6.278E-1
 3 189
10 4306 DN Deltaline [6836-11-9]; Down 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.928E-4 2.747E-2
2.385E-1
6.376E-1
 3 190
11 4303 DN Flunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.958E-4 2.747E-2
2.385E-1
6.476E-1
 3 191
12 4273 DN Flunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.958E-4 2.747E-2
2.385E-1
6.476E-1
 3 191
13 5362 UP Nilutamide [63612-50-0]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.050E-4 2.747E-2
2.385E-1
6.780E-1
 3 194
14 4305 DN Solasodine [126-17-0]; Down 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.050E-4 2.747E-2
2.385E-1
6.780E-1
 3 194
15 4312 DN Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.050E-4 2.747E-2
2.385E-1
6.780E-1
 3 194
16 2956 DN Torsemide [56211-40-6]; Down 200; 11.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.081E-4 2.747E-2
2.385E-1
6.884E-1
 3 195
17 1948 DN Diltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; PC3; HG-U133A Broad Institute CMAP Down 2.112E-4 2.747E-2
2.385E-1
6.988E-1
 3 196
18 5016 DN Brinzolamide [138890-62-7]; Down 200; 10.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.144E-4 2.747E-2
2.385E-1
7.094E-1
 3 197
19 4836 DN Dydrogesterone [152-62-5]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.144E-4 2.747E-2
2.385E-1
7.094E-1
 3 197
20 7035 UP Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.177E-4 2.747E-2
2.385E-1
7.200E-1
 3 198
21 3882 DN Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.177E-4 2.747E-2
2.385E-1
7.200E-1
 3 198
22 949 DN 5255229; Down 200; 13uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 2.177E-4 2.747E-2
2.385E-1
7.200E-1
 3 198
23 2046 DN Lisuride (S)(-) [18016-80-3]; Down 200; 11.8uM; HL60; HG-U133A Broad Institute CMAP Down 2.209E-4 2.747E-2
2.385E-1
7.308E-1
 3 199
24 4606 UP Metyrapone [54-36-4]; Up 200; 17.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.209E-4 2.747E-2
2.385E-1
7.308E-1
 3 199
25 6524 DN Isometheptene mucate; Down 200; 8.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.209E-4 2.747E-2
2.385E-1
7.308E-1
 3 199
26 7254 DN Talampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.209E-4 2.747E-2
2.385E-1
7.308E-1
 3 199
27 1282 DN Buspirone hydrochloride [33386-08-2]; Down 200; 9.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.242E-4 2.747E-2
2.385E-1
7.416E-1
 3 200
28 CID000200884 P-15 Stitch 3.046E-4 3.599E-2
3.124E-1
1.000E0
 3 222
Show 23 more annotations

18: Disease [Display Chart] 14 input genes in category / 401 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3888194 MIXED LINEAGE LEUKEMIA DisGeNET BeFree 1.537E-5 6.165E-3 4.052E-2 6.165E-3 4 186
2 C1857451 Acth-Independent Macronodular Adrenal Hyperplasia DisGeNET Curated 1.175E-4 1.571E-2
1.033E-1
 4.713E-2 2 19
3 C0281784 Benign Meningioma DisGeNET BeFree 1.175E-4 1.571E-2
1.033E-1
 4.713E-2 2 19
4 C0030521 Parathyroid Neoplasms DisGeNET Curated 7.964E-4 3.464E-2
2.277E-1
3.194E-1
 2 49
5 cv:C0025267 Multiple endocrine neoplasia, type 1 Clinical Variations 8.639E-4 3.464E-2
2.277E-1
3.464E-1
 1 1
6 C0154040 Benign neoplasm of adrenal gland DisGeNET BeFree 8.639E-4 3.464E-2
2.277E-1
3.464E-1
 1 1
7 C1333963 Liver Neuroendocrine Tumor DisGeNET BeFree 8.639E-4 3.464E-2
2.277E-1
3.464E-1
 1 1
8 C0238374 PITUITARY ADENOMA, NON-SECRETING DisGeNET BeFree 8.639E-4 3.464E-2
2.277E-1
3.464E-1
 1 1
9 cv:C0796208 X-linked mental retardation 3 Clinical Variations 8.639E-4 3.464E-2
2.277E-1
3.464E-1
 1 1
10 C1717804 Emphysema or COPD DisGeNET BeFree 8.639E-4 3.464E-2
2.277E-1
3.464E-1
 1 1
11 C0031511 Pheochromocytoma DisGeNET Curated 1.663E-3 3.709E-2
2.438E-1
6.669E-1
 3 283
12 C1368066 pancreatic gastrinoma DisGeNET BeFree 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
13 C1861848 PARAGANGLIOMAS 4 DisGeNET Curated 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
14 C1275273 Familial Multiple Lipomatosis DisGeNET BeFree 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
15 C0796208 MENTAL RETARDATION, X-LINKED 3 DisGeNET Curated 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
16 C4023401 Abnormality of hair density DisGeNET Curated 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
17 OMIN:145000 HYPERPARATHYROIDISM 1; HRPT1 OMIM 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
18 C4024716 Secondary growth hormone deficiency DisGeNET Curated 1.727E-3 3.709E-2
2.438E-1
6.926E-1
 1 2
19 C0236733 Amphetamine-Related Disorders DisGeNET Curated 1.855E-3 3.709E-2
2.438E-1
7.440E-1
 2 75
20 C0033375 Prolactinoma DisGeNET Curated 2.213E-3 3.709E-2
2.438E-1
8.873E-1
 2 82
21 C0030421 Paraganglioma DisGeNET Curated 2.266E-3 3.709E-2
2.438E-1
9.088E-1
 2 83
22 C4022676 Decreased female libido DisGeNET Curated 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
23 C1851959 Fluctuations in consciousness DisGeNET Curated 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
24 C1851705 Confetti-like hypopigmented macules DisGeNET Curated 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
25 C1266032 Atypical carcinoid tumor DisGeNET BeFree 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
26 C2931039 Pancreatic islet cell tumors DisGeNET BeFree 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
27 C0475732 Hypercalcemia, Infantile DisGeNET Curated 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
28 C0346308 Pituitary macroadenoma DisGeNET BeFree 2.590E-3 3.709E-2
2.438E-1
1.000E0
 1 3
29 C0271710 Reactive hypoglycemia DisGeNET Curated 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
30 C4023211 Adrenocorticotropin deficient adrenal insufficiency DisGeNET Curated 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
31 C1846288 Recurrent hypoglycemia DisGeNET Curated 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
32 C0344453 Macroprolactinoma DisGeNET BeFree 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
33 C0238114 Leiomyoma of esophagus DisGeNET BeFree 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
34 C4025043 Abnormality of the pancreatic islet cells DisGeNET Curated 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
35 C0271858 Tertiary hyperparathyroidism DisGeNET BeFree 3.452E-3 3.955E-2
2.599E-1
1.000E0
 1 4
36 C0025267 Multiple Endocrine Neoplasia Type 1 DisGeNET Curated 4.224E-3 3.966E-2
2.607E-1
1.000E0
 2 114
37 C1860243 Sternal ossification center abnormalities DisGeNET Curated 4.313E-3 3.966E-2
2.607E-1
1.000E0
 1 5
38 C2676191 PITUITARY ADENOMA, FAMILIAL ISOLATED (disorder) DisGeNET Curated 4.313E-3 3.966E-2
2.607E-1
1.000E0
 1 5
39 C4025320 Craniofacial asymmetry DisGeNET Curated 4.313E-3 3.966E-2
2.607E-1
1.000E0
 1 5
40 OMIN:194190 WOLF-HIRSCHHORN SYNDROME; WHS OMIM 4.313E-3 3.966E-2
2.607E-1
1.000E0
 1 5
41 C0011993 Vipoma DisGeNET Curated 4.313E-3 3.966E-2
2.607E-1
1.000E0
 1 5
42 C1955745 Multiple endocrine neoplasia (MEN) Syndrome DisGeNET BeFree 4.313E-3 3.966E-2
2.607E-1
1.000E0
 1 5
43 C0025286 Meningioma DisGeNET Curated 4.722E-3 3.966E-2
2.607E-1
1.000E0
 3 409
44 C1865292 Nonketotic hypoglycemia DisGeNET Curated 5.173E-3 3.966E-2
2.607E-1
1.000E0
 1 6
45 C1860244 Malrotation of small bowel DisGeNET Curated 5.173E-3 3.966E-2
2.607E-1
1.000E0
 1 6
46 C3805887 Generalized osteoporosis with pathologic fractures DisGeNET Curated 5.173E-3 3.966E-2
2.607E-1
1.000E0
 1 6
47 C0271846 Familial hyperparathyroidism DisGeNET BeFree 5.173E-3 3.966E-2
2.607E-1
1.000E0
 1 6
48 C1271219 Congenital ectopic pupil DisGeNET Curated 6.033E-3 3.966E-2
2.607E-1
1.000E0
 1 7
49 C0266631 Accessory spleen DisGeNET Curated 6.033E-3 3.966E-2
2.607E-1
1.000E0
 1 7
50 C0151640 Decreased male fertility DisGeNET Curated 6.033E-3 3.966E-2
2.607E-1
1.000E0
 1 7
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