Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc195_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 14 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001055 RNA polymerase II activity 7.286E-31 1.020E-29 3.317E-29 1.020E-29 9 10
2 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 3.180E-26 2.226E-25 7.237E-25 4.451E-25 10 46
3 GO:0034062 5'-3' RNA polymerase activity 5.101E-26 2.381E-25 7.741E-25 7.142E-25 10 48
4 GO:0016779 nucleotidyltransferase activity 2.424E-21 8.483E-21 2.758E-20 3.393E-20 10 132
5 GO:0001054 RNA polymerase I activity 1.938E-14 5.426E-14 1.764E-13 2.713E-13 5 12
6 GO:0001056 RNA polymerase III activity 2.093E-13 4.883E-13 1.588E-12 2.930E-12 5 18
7 GO:0003968 RNA-directed 5'-3' RNA polymerase activity 1.179E-3 2.357E-3 7.665E-3 1.650E-2 1 2
8 GO:0030275 LRR domain binding 1.173E-2 2.053E-2
6.674E-2
1.642E-1
 1 20
9 GO:0031369 translation initiation factor binding 2.044E-2 3.180E-2
1.034E-1
2.862E-1
 1 35
Show 4 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 122 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050434 positive regulation of viral transcription 7.181E-31 8.761E-29 4.718E-28 8.761E-29 11 39
2 GO:0046782 regulation of viral transcription 1.791E-28 1.093E-26 5.884E-26 2.185E-26 11 61
3 GO:0006370 7-methylguanosine mRNA capping 7.373E-28 2.998E-26 1.615E-25 8.995E-26 10 33
4 GO:0036260 RNA capping 3.765E-27 9.186E-26 4.947E-25 4.593E-25 10 38
5 GO:0009452 7-methylguanosine RNA capping 3.765E-27 9.186E-26 4.947E-25 4.593E-25 10 38
6 GO:1903902 positive regulation of viral life cycle 1.200E-26 2.440E-25 1.314E-24 1.464E-24 11 87
7 GO:0048524 positive regulation of viral process 2.958E-26 5.155E-25 2.776E-24 3.609E-24 11 94
8 GO:0006368 transcription elongation from RNA polymerase II promoter 4.262E-26 6.499E-25 3.500E-24 5.199E-24 11 97
9 GO:0006354 DNA-templated transcription, elongation 7.945E-25 1.077E-23 5.800E-23 9.692E-23 11 125
10 GO:0009301 snRNA transcription 3.154E-24 3.498E-23 1.884E-22 3.848E-22 10 70
11 GO:0042795 snRNA transcription by RNA polymerase II 3.154E-24 3.498E-23 1.884E-22 3.848E-22 10 70
12 GO:0006283 transcription-coupled nucleotide-excision repair 4.940E-24 5.022E-23 2.704E-22 6.026E-22 10 73
13 GO:0035019 somatic stem cell population maintenance 8.719E-24 8.183E-23 4.407E-22 1.064E-21 10 77
14 GO:0016073 snRNA metabolic process 1.933E-23 1.684E-22 9.070E-22 2.358E-21 10 83
15 GO:0043902 positive regulation of multi-organism process 2.312E-23 1.880E-22 1.012E-21 2.820E-21 11 168
16 GO:0019083 viral transcription 3.916E-23 2.811E-22 1.514E-21 4.778E-21 11 176
17 GO:1903900 regulation of viral life cycle 3.916E-23 2.811E-22 1.514E-21 4.778E-21 11 176
18 GO:0019080 viral gene expression 7.777E-23 5.271E-22 2.839E-21 9.488E-21 11 187
19 GO:0050792 regulation of viral process 8.771E-23 5.632E-22 3.033E-21 1.070E-20 11 189
20 GO:0098781 ncRNA transcription 1.873E-22 1.142E-21 6.152E-21 2.285E-20 10 103
21 GO:0044033 multi-organism metabolic process 2.449E-22 1.423E-21 7.662E-21 2.988E-20 11 207
22 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 4.865E-22 2.613E-21 1.407E-20 5.935E-20 11 220
23 GO:0008543 fibroblast growth factor receptor signaling pathway 4.926E-22 2.613E-21 1.407E-20 6.010E-20 10 113
24 GO:0006289 nucleotide-excision repair 8.439E-22 4.290E-21 2.310E-20 1.030E-19 10 119
25 GO:0044344 cellular response to fibroblast growth factor stimulus 3.369E-21 1.644E-20 8.854E-20 4.110E-19 10 136
26 GO:0071774 response to fibroblast growth factor 5.263E-21 2.469E-20 1.330E-19 6.421E-19 10 142
27 GO:0031047 gene silencing by RNA 1.688E-20 7.626E-20 4.107E-19 2.059E-18 10 159
28 GO:0019827 stem cell population maintenance 4.261E-20 1.857E-19 9.999E-19 5.199E-18 10 174
29 GO:0006367 transcription initiation from RNA polymerase II promoter 4.519E-20 1.901E-19 1.024E-18 5.513E-18 10 175
30 GO:0098727 maintenance of cell number 5.078E-20 2.065E-19 1.112E-18 6.195E-18 10 177
31 GO:0006352 DNA-templated transcription, initiation 8.428E-19 3.317E-18 1.786E-17 1.028E-16 10 233
32 GO:0019058 viral life cycle 1.350E-18 5.146E-18 2.771E-17 1.647E-16 11 447
33 GO:0016458 gene silencing 2.197E-18 8.122E-18 4.374E-17 2.680E-16 10 256
34 GO:0006397 mRNA processing 2.912E-18 1.045E-17 5.627E-17 3.553E-16 11 479
35 GO:0000398 mRNA splicing, via spliceosome 1.300E-17 4.405E-17 2.372E-16 1.586E-15 10 305
36 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.300E-17 4.405E-17 2.372E-16 1.586E-15 10 305
37 GO:0000375 RNA splicing, via transesterification reactions 1.483E-17 4.891E-17 2.634E-16 1.810E-15 10 309
38 GO:0008380 RNA splicing 2.122E-16 6.814E-16 3.669E-15 2.589E-14 10 402
39 GO:0006362 transcription elongation from RNA polymerase I promoter 4.178E-12 1.307E-11 7.039E-11 5.097E-10 5 31
40 GO:0006363 termination of RNA polymerase I transcription 4.951E-12 1.510E-11 8.132E-11 6.040E-10 5 32
41 GO:0006361 transcription initiation from RNA polymerase I promoter 6.837E-12 2.034E-11 1.096E-10 8.341E-10 5 34
42 GO:0006353 DNA-templated transcription, termination 1.051E-11 3.053E-11 1.644E-10 1.282E-9 6 102
43 GO:0006383 transcription by RNA polymerase III 7.729E-11 2.193E-10 1.181E-9 9.429E-9 5 54
44 GO:0006360 transcription by RNA polymerase I 1.451E-10 4.024E-10 2.167E-9 1.770E-8 5 61
45 GO:0032481 positive regulation of type I interferon production 3.403E-10 9.226E-10 4.968E-9 4.152E-8 5 72
46 GO:0045815 positive regulation of gene expression, epigenetic 6.216E-10 1.649E-9 8.879E-9 7.584E-8 5 81
47 GO:0032479 regulation of type I interferon production 4.026E-9 1.045E-8 5.628E-8 4.912E-7 5 117
48 GO:0032606 type I interferon production 4.386E-9 1.115E-8 6.003E-8 5.351E-7 5 119
49 GO:0040029 regulation of gene expression, epigenetic 2.420E-7 6.026E-7 3.245E-6 2.953E-5 5 265
50 GO:0001819 positive regulation of cytokine production 2.299E-6 5.609E-6 3.021E-5 2.805E-4 5 418
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005665 RNA polymerase II, core complex 1.229E-31 2.703E-30 9.977E-30 2.703E-30 10 17
2 GO:0016591 RNA polymerase II, holoenzyme 8.815E-23 9.696E-22 3.579E-21 1.939E-21 10 98
3 GO:0055029 nuclear DNA-directed RNA polymerase complex 7.954E-22 4.375E-21 1.615E-20 1.750E-20 10 121
4 GO:0000428 DNA-directed RNA polymerase complex 7.954E-22 4.375E-21 1.615E-20 1.750E-20 10 121
5 GO:0030880 RNA polymerase complex 1.026E-21 4.513E-21 1.666E-20 2.257E-20 10 124
6 GO:0061695 transferase complex, transferring phosphorus-containing groups 1.069E-18 3.918E-18 1.446E-17 2.351E-17 10 244
7 GO:0005736 RNA polymerase I complex 2.831E-14 8.898E-14 3.284E-13 6.229E-13 5 13
8 GO:0005666 RNA polymerase III complex 1.882E-13 5.177E-13 1.911E-12 4.141E-12 5 18
9 GO:0044452 nucleolar part 2.623E-10 6.412E-10 2.366E-9 5.771E-9 5 70
10 GO:0032021 NELF complex 2.307E-3 5.074E-3 1.873E-2
5.074E-2
 1 4
11 GO:0000974 Prp19 complex 8.052E-3 1.610E-2
5.944E-2
1.771E-1
 1 14
12 GO:0005719 nuclear euchromatin 1.718E-2 3.150E-2
1.163E-1
3.780E-1
 1 30
13 GO:0000791 euchromatin 2.285E-2 3.867E-2
1.427E-1
5.027E-1
 1 40
14 GO:0008023 transcription elongation factor complex 2.849E-2 4.476E-2
1.652E-1
6.267E-1
 1 50
Show 9 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 180 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000458 Anosmia 4.836E-4 3.824E-2
2.207E-1
8.705E-2
 2 104
2 HP:0004408 Abnormality of the sense of smell 6.664E-4 3.824E-2
2.207E-1
1.200E-1
 2 122
3 HP:0011379 Dilated vestibule of the inner ear 8.497E-4 3.824E-2
2.207E-1
1.529E-1
 1 2
4 HP:0011285 Long-segment aganglionic megacolon 8.497E-4 3.824E-2
2.207E-1
1.529E-1
 1 2

5: Mouse Phenotype [Display Chart] 3 input genes in category / 132 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 11 input genes in category / 103 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01193 RNA pol L Pfam 4.695E-6 2.418E-4 1.261E-3 4.836E-4 2 6
2 IPR009025 RBP11-like dimer InterPro 4.695E-6 2.418E-4 1.261E-3 4.836E-4 2 6
3 3.90.940.10 - Gene3D 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
4 IPR028363 RPB6 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
5 PD005155 RNA pol subH/Rpb5 C ProDom 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
6 PF01192 RNA pol Rpb6 Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
7 PS00115 RNA POL II REPEAT PROSITE 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
8 IPR023580 RNA pol su RPB10 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
9 SM00659 RPOLCX SMART 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
10 IPR000268 RNAP N/Rpb10 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
11 PS01112 RNA POL N 8KD PROSITE 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
12 3.40.1340.10 - Gene3D 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
13 PS01111 RNA POL K 14KD PROSITE 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
14 3.90.940.20 - Gene3D 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
15 SM00658 RPOL8c SMART 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
16 PF04992 RNA pol Rpb1 6 Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
17 IPR020608 RNA pol subH/Rpb5 CS InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
18 IPR000783 RNA pol subH/Rpb5 C InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
19 2.20.28.30 - Gene3D 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
20 IPR020708 DNA-dir RNA polK 14-18kDa CS InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
21 IPR012293 RNAP RPB6 omega InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
22 IPR006111 RpoK/Rpb6 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
23 SM01409 RNA pol Rpb6 SMART 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
24 IPR005570 RNA pol Rpb8 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
25 IPR020789 RNA pol suN Zn-BS InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
26 PF03870 RNA pol Rpb8 Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
27 IPR020609 RpoH/RPB5 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
28 IPR014381 DNA RNA pol RPB5 euk/virus InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
29 PF04990 RNA pol Rpb1 7 Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
30 PD006539 RNA pol N/8 sub ProDom 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
31 IPR005571 RNA pol Rpb5 N InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
32 PS01110 RNA POL H 23KD PROSITE 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
33 IPR033102 NELFE InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
34 IPR007073 RNA pol Rpb1 7 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
35 IPR006110 Pol omega/K/RPB6 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
36 IPR006591 RNAP P/RPABC4 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
37 IPR007075 RNA pol Rpb1 6 InterPro 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
38 PF01191 RNA pol Rpb5 C Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
39 PF03871 RNA pol Rpb5 N Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
40 PF01194 RNA pol N Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
41 PF03604 DNA RNApol 7kD Pfam 5.871E-4 1.475E-3 7.695E-3
6.048E-2
 1 1
42 IPR012340 NA-bd OB-fold InterPro 1.064E-3 2.037E-3 1.063E-2
1.096E-1
 2 84
43 IPR001514 DNA-dir RNA pol 30-40kDasu CS InterPro 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
44 SM00662 RPOLD SMART 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
45 IPR011262 DNA-dir RNA pol insert InterPro 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
46 IPR011263 DNA-dir RNA pol RpoA/D/Rpb3 InterPro 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
47 PF01000 RNA pol A bac Pfam 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
48 2.170.120.12 - Gene3D 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
49 3.30.1490.120 - Gene3D 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
50 PF05001 RNA pol Rpb1 R Pfam 1.174E-3 2.037E-3 1.063E-2
1.209E-1
 1 2
Show 45 more annotations

7: Pathway [Display Chart] 11 input genes in category / 101 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269078 Abortive elongation of HIV-1 transcript in the absence of Tat BioSystems: REACTOME 1.604E-31 1.620E-29 8.422E-29 1.620E-29 11 25
2 MAP03020 RNA polymerase MAP03020 RNA polymerase GenMAPP 8.703E-30 3.792E-28 1.971E-27 8.790E-28 10 17
3 1269075 Formation of the HIV-1 Early Elongation Complex BioSystems: REACTOME 1.502E-29 3.792E-28 1.971E-27 1.517E-27 11 35
4 1269683 Formation of the Early Elongation Complex BioSystems: REACTOME 1.502E-29 3.792E-28 1.971E-27 1.517E-27 11 35
5 1383045 Signaling by FGFR2 IIIa TM BioSystems: REACTOME 4.133E-29 8.350E-28 4.340E-27 4.175E-27 10 19
6 1269082 Tat-mediated HIV elongation arrest and recovery BioSystems: REACTOME 8.321E-29 1.201E-27 6.240E-27 8.404E-27 11 40
7 1269083 Pausing and recovery of Tat-mediated HIV elongation BioSystems: REACTOME 8.321E-29 1.201E-27 6.240E-27 8.404E-27 11 40
8 1269079 HIV elongation arrest and recovery BioSystems: REACTOME 1.541E-28 1.729E-27 8.986E-27 1.556E-26 11 42
9 1269081 Pausing and recovery of HIV elongation BioSystems: REACTOME 1.541E-28 1.729E-27 8.986E-27 1.556E-26 11 42
10 1269720 MicroRNA (miRNA) biogenesis BioSystems: REACTOME 1.462E-27 1.477E-26 7.674E-26 1.477E-25 10 25
11 1269076 Tat-mediated elongation of the HIV-1 transcript BioSystems: REACTOME 2.174E-27 1.689E-26 8.779E-26 2.196E-25 11 52
12 1269074 HIV Transcription Elongation BioSystems: REACTOME 2.174E-27 1.689E-26 8.779E-26 2.196E-25 11 52
13 1269077 Formation of HIV-1 elongation complex containing HIV-1 Tat BioSystems: REACTOME 2.174E-27 1.689E-26 8.779E-26 2.196E-25 11 52
14 1269080 Formation of HIV elongation complex in the absence of HIV Tat BioSystems: REACTOME 3.445E-27 2.381E-26 1.238E-25 3.480E-25 11 54
15 1269073 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection BioSystems: REACTOME 3.773E-27 2.381E-26 1.238E-25 3.810E-25 10 27
16 1269681 RNA Pol II CTD phosphorylation and interaction with CE BioSystems: REACTOME 3.773E-27 2.381E-26 1.238E-25 3.810E-25 10 27
17 1383022 FGFR2 alternative splicing BioSystems: REACTOME 5.868E-27 3.486E-26 1.812E-25 5.927E-25 10 28
18 1269724 PIWI-interacting RNA (piRNA) biogenesis BioSystems: REACTOME 8.956E-27 4.761E-26 2.474E-25 9.045E-25 10 29
19 1269687 mRNA Capping BioSystems: REACTOME 8.956E-27 4.761E-26 2.474E-25 9.045E-25 10 29
20 83037 RNA polymerase BioSystems: KEGG 2.884E-26 1.456E-25 7.569E-25 2.913E-24 10 32
21 1268870 FGFR2 mutant receptor activation BioSystems: REACTOME 4.137E-26 1.990E-25 1.034E-24 4.179E-24 10 33
22 1269682 RNA Polymerase II Transcription Elongation BioSystems: REACTOME 4.625E-26 2.031E-25 1.056E-24 4.672E-24 11 67
23 1269684 Formation of RNA Pol II elongation complex BioSystems: REACTOME 4.625E-26 2.031E-25 1.056E-24 4.672E-24 11 67
24 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 1.088E-25 4.578E-25 2.379E-24 1.099E-23 11 72
25 1270346 Transcriptional regulation of pluripotent stem cells BioSystems: REACTOME 1.136E-25 4.589E-25 2.385E-24 1.147E-23 10 36
26 1269070 Transcription of the HIV genome BioSystems: REACTOME 3.253E-25 1.264E-24 6.567E-24 3.285E-23 11 79
27 1268869 Signaling by FGFR2 in disease BioSystems: REACTOME 8.564E-25 3.089E-24 1.606E-23 8.650E-23 10 43
28 1269117 Viral Messenger RNA Synthesis BioSystems: REACTOME 8.564E-25 3.089E-24 1.606E-23 8.650E-23 10 43
29 MAP00240 Pyrimidine metabolism MAP00240 Pyrimidine metabolism GenMAPP 1.108E-24 3.860E-24 2.006E-23 1.119E-22 10 44
30 1269676 RNA Polymerase II Pre-transcription Events BioSystems: REACTOME 1.497E-24 5.041E-24 2.620E-23 1.512E-22 11 90
31 1269680 RNA Polymerase II Promoter Escape BioSystems: REACTOME 2.312E-24 6.487E-24 3.371E-23 2.335E-22 10 47
32 1269678 RNA Polymerase II Transcription Initiation And Promoter Clearance BioSystems: REACTOME 2.312E-24 6.487E-24 3.371E-23 2.335E-22 10 47
33 1269677 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening BioSystems: REACTOME 2.312E-24 6.487E-24 3.371E-23 2.335E-22 10 47
34 1269071 HIV Transcription Initiation BioSystems: REACTOME 2.312E-24 6.487E-24 3.371E-23 2.335E-22 10 47
35 1269072 RNA Polymerase II HIV Promoter Escape BioSystems: REACTOME 2.312E-24 6.487E-24 3.371E-23 2.335E-22 10 47
36 1269679 RNA Polymerase II Transcription Initiation BioSystems: REACTOME 2.312E-24 6.487E-24 3.371E-23 2.335E-22 10 47
37 1269691 mRNA Splicing - Minor Pathway BioSystems: REACTOME 8.703E-24 2.376E-23 1.235E-22 8.790E-22 10 53
38 1309118 Formation of TC-NER Pre-Incision Complex BioSystems: REACTOME 1.068E-23 2.839E-23 1.475E-22 1.079E-21 10 54
39 1268863 Signaling by FGFR in disease BioSystems: REACTOME 5.700E-23 1.476E-22 7.672E-22 5.757E-21 10 63
40 1309120 Gap-filling DNA repair synthesis and ligation in TC-NER BioSystems: REACTOME 7.983E-23 2.016E-22 1.048E-21 8.063E-21 10 65
41 1309119 Dual incision in TC-NER BioSystems: REACTOME 9.408E-23 2.318E-22 1.205E-21 9.502E-21 10 66
42 1269069 Late Phase of HIV Life Cycle BioSystems: REACTOME 2.647E-22 6.364E-22 3.308E-21 2.673E-20 11 141
43 1383088 RNA polymerase II transcribes snRNA genes BioSystems: REACTOME 2.769E-22 6.504E-22 3.380E-21 2.797E-20 10 73
44 1269399 Signaling by FGFR2 BioSystems: REACTOME 3.694E-22 8.479E-22 4.407E-21 3.731E-20 10 75
45 1309117 Transcription-Coupled Nucleotide Excision Repair (TC-NER) BioSystems: REACTOME 6.418E-22 1.441E-21 7.487E-21 6.482E-20 10 79
46 1269058 HIV Life Cycle BioSystems: REACTOME 7.228E-22 1.587E-21 8.248E-21 7.300E-20 11 154
47 MAP00230 Purine metabolism MAP00230 Purine metabolism GenMAPP 1.230E-21 2.642E-21 1.373E-20 1.242E-19 10 84
48 1269675 RNA Polymerase II Transcription BioSystems: REACTOME 1.285E-21 2.704E-21 1.406E-20 1.298E-19 11 162
49 1269386 Signaling by FGFR BioSystems: REACTOME 2.264E-21 4.666E-21 2.425E-20 2.286E-19 10 89
50 82946 Pyrimidine metabolism BioSystems: KEGG 1.283E-20 2.591E-20 1.347E-19 1.296E-18 10 105
Show 45 more annotations

8: Pubmed [Display Chart] 11 input genes in category / 763 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9201987 Interactions between the human RNA polymerase II subunits. Pubmed 6.051E-39 4.617E-36 3.331E-35 4.617E-36 10 10
2 16838299 The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. Pubmed 2.662E-38 6.770E-36 4.884E-35 2.031E-35 11 20
3 11112772 DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation. Pubmed 2.662E-38 6.770E-36 4.884E-35 2.031E-35 11 20
4 10069959 Human immunodeficiency virus type 1 Tat-dependent activation of an arrested RNA polymerase II elongation complex. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
5 2190099 Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
6 21972559 [Positive and negative regulation of transcription from HIV provirus]. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
7 8910388 Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
8 8637904 Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
9 12126615 A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
10 8876177 Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. Pubmed 3.993E-37 3.047E-35 2.198E-34 3.047E-34 10 12
11 10373521 Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. Pubmed 1.730E-36 8.252E-35 5.954E-34 1.320E-33 10 13
12 10784442 Architecture of RNA polymerase II and implications for the transcription mechanism. Pubmed 1.730E-36 8.252E-35 5.954E-34 1.320E-33 10 13
13 7638159 Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Pubmed 1.730E-36 8.252E-35 5.954E-34 1.320E-33 10 13
14 10698937 TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes. Pubmed 1.730E-36 8.252E-35 5.954E-34 1.320E-33 10 13
15 18218627 Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9. Pubmed 1.730E-36 8.252E-35 5.954E-34 1.320E-33 10 13
16 10725406 BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription. Pubmed 1.730E-36 8.252E-35 5.954E-34 1.320E-33 10 13
17 12114499 HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
18 23274668 Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
19 10364292 Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
20 8676484 The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
21 10329125 Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
22 10536359 Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
23 7853496 Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
24 9696809 The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. Pubmed 6.057E-36 1.925E-34 1.389E-33 4.621E-33 10 14
25 22211660 Control of HIV latency by epigenetic and non-epigenetic mechanisms. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
26 12887902 Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
27 24217245 Tip110 protein binds to unphosphorylated RNA polymerase II and promotes its phosphorylation and HIV-1 long terminal repeat transcription. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
28 10359081 The HIV-1 Vpr co-activator induces a conformational change in TFIIB. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
29 11809800 Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
30 12049628 HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
31 9491887 A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
32 10704353 Phosphorylation of the RAP74 subunit of TFIIF correlates with Tat-activated transcription of the HIV-1 long terminal repeat. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
33 10931842 Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome. Pubmed 1.817E-35 4.201E-34 3.031E-33 1.386E-32 10 15
34 12676794 The RNA polymerase II elongation complex. Pubmed 3.067E-35 6.883E-34 4.966E-33 2.340E-32 11 33
35 12642036 HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
36 12221105 Transcriptional activators differ in their abilities to control alternative splicing. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
37 12052871 Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
38 23028129 HIV-1 reverse transcription. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
39 8800208 The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
40 10757782 Domains in the SPT5 protein that modulate its transcriptional regulatory properties. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
41 12634356 Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
42 22229121 HIV latency. Pubmed 4.845E-35 8.802E-34 6.351E-33 3.697E-32 10 16
43 9874563 The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor. Pubmed 1.177E-34 1.870E-33 1.349E-32 8.978E-32 10 17
44 11547919 Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. Pubmed 1.177E-34 1.870E-33 1.349E-32 8.978E-32 10 17
45 10545121 HIV-1 tat transcriptional activity is regulated by acetylation. Pubmed 1.177E-34 1.870E-33 1.349E-32 8.978E-32 10 17
46 10958691 CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA. Pubmed 1.177E-34 1.870E-33 1.349E-32 8.978E-32 10 17
47 10393184 A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription. Pubmed 1.177E-34 1.870E-33 1.349E-32 8.978E-32 10 17
48 1559613 HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. Pubmed 1.177E-34 1.870E-33 1.349E-32 8.978E-32 10 17
49 9315662 CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. Pubmed 2.647E-34 3.961E-33 2.858E-32 2.020E-31 10 18
50 17168834 Will diverse Tat interactions lead to novel antiretroviral drug targets? Pubmed 2.647E-34 3.961E-33 2.858E-32 2.020E-31 10 18
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 543 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:POLR2C POLR2C interactions 4.350E-25 2.252E-22 1.548E-21 2.362E-22 11 113
2 int:MED19 MED19 interactions 8.296E-25 2.252E-22 1.548E-21 4.505E-22 10 59
3 int:MED10 MED10 interactions 2.785E-24 3.559E-22 2.447E-21 1.512E-21 10 66
4 int:ELOA ELOA interactions 3.273E-24 3.559E-22 2.447E-21 1.777E-21 10 67
5 int:POLR2K POLR2K interactions 3.277E-24 3.559E-22 2.447E-21 1.779E-21 9 32
6 int:PSMB9 PSMB9 interactions 7.075E-24 6.403E-22 4.402E-21 3.842E-21 10 72
7 int:POLR2H POLR2H interactions 1.660E-23 1.288E-21 8.852E-21 9.013E-21 10 78
8 int:MED26 MED26 interactions 6.704E-23 4.550E-21 3.128E-20 3.640E-20 10 89
9 int:POLR2G POLR2G interactions 1.192E-22 7.190E-21 4.943E-20 6.471E-20 10 94
10 int:POLR2I POLR2I interactions 4.290E-22 2.329E-20 1.601E-19 2.329E-19 9 52
11 int:MED29 MED29 interactions 1.722E-21 8.502E-20 5.845E-19 9.352E-19 9 60
12 int:POLR2J POLR2J interactions 2.756E-21 1.247E-19 8.576E-19 1.497E-18 9 63
13 int:POLR2E POLR2E interactions 5.590E-21 2.335E-19 1.605E-18 3.035E-18 10 136
14 int:POLR2B POLR2B interactions 7.004E-21 2.717E-19 1.868E-18 3.803E-18 10 139
15 int:POLR2D POLR2D interactions 7.569E-21 2.740E-19 1.884E-18 4.110E-18 9 70
16 int:POLR2F POLR2F interactions 1.130E-20 3.833E-19 2.635E-18 6.133E-18 9 73
17 int:RPAP2 RPAP2 interactions 1.657E-20 5.293E-19 3.639E-18 8.998E-18 9 76
18 int:POLR2A POLR2A interactions 8.856E-20 2.671E-18 1.837E-17 4.809E-17 11 333
19 int:INTS5 INTS5 interactions 3.485E-19 9.959E-18 6.847E-17 1.892E-16 9 105
20 int:GTF2F2 GTF2F2 interactions 8.351E-19 2.267E-17 1.559E-16 4.534E-16 8 55
21 int:INTS6 INTS6 interactions 1.754E-18 4.534E-17 3.117E-16 9.522E-16 8 60
22 int:POLR2M POLR2M interactions 3.032E-18 7.483E-17 5.144E-16 1.646E-15 8 64
23 int:RPRD1B RPRD1B interactions 1.981E-17 4.481E-16 3.081E-15 1.075E-14 8 80
24 int:MED9 MED9 interactions 1.981E-17 4.481E-16 3.081E-15 1.075E-14 8 80
25 int:SUPT5H SUPT5H interactions 3.035E-17 6.592E-16 4.532E-15 1.648E-14 9 170
26 int:SRC SRC interactions 3.793E-16 7.923E-15 5.447E-14 2.060E-13 10 405
27 int:POLR2L POLR2L interactions 1.319E-15 2.653E-14 1.824E-13 7.162E-13 7 61
28 int:GPN3 GPN3 interactions 2.103E-15 4.079E-14 2.804E-13 1.142E-12 7 65
29 int:INTS3 INTS3 interactions 7.248E-15 1.357E-13 9.330E-13 3.935E-12 7 77
30 int:MED28 MED28 interactions 1.909E-14 3.455E-13 2.376E-12 1.037E-11 7 88
31 int:LMO2 LMO2 interactions 5.491E-14 9.618E-13 6.613E-12 2.982E-11 8 210
32 int:GTF2B GTF2B interactions 6.368E-14 1.081E-12 7.429E-12 3.458E-11 7 104
33 int:POLR1C POLR1C interactions 2.121E-13 3.490E-12 2.400E-11 1.152E-10 7 123
34 int:RECQL5 RECQL5 interactions 3.098E-13 4.948E-12 3.402E-11 1.682E-10 6 55
35 int:CTDP1 CTDP1 interactions 5.344E-13 8.291E-12 5.701E-11 2.902E-10 6 60
36 int:INTS10 INTS10 interactions 3.115E-12 4.699E-11 3.230E-10 1.692E-9 5 28
37 int:POLR1A POLR1A interactions 9.810E-12 1.440E-10 9.898E-10 5.327E-9 6 96
38 int:GTF2F1 GTF2F1 interactions 1.423E-11 2.033E-10 1.398E-9 7.726E-9 6 102
39 int:POLR1D POLR1D interactions 4.323E-11 6.019E-10 4.138E-9 2.347E-8 5 46
40 int:RNGTT RNGTT interactions 1.316E-10 1.787E-9 1.229E-8 7.148E-8 5 57
41 int:POLR1B POLR1B interactions 3.267E-10 4.224E-9 2.904E-8 1.774E-7 5 68
42 int:GPN1 GPN1 interactions 3.267E-10 4.224E-9 2.904E-8 1.774E-7 5 68
43 int:WDR92 WDR92 interactions 5.777E-10 7.295E-9 5.015E-8 3.137E-7 5 76
44 int:POLR3A POLR3A interactions 7.041E-10 8.689E-9 5.974E-8 3.823E-7 5 79
45 int:NELFA NELFA interactions 1.405E-9 1.696E-8 1.166E-7 7.631E-7 4 27
46 int:POLR3D POLR3D interactions 7.288E-9 8.603E-8 5.915E-7 3.958E-6 4 40
47 int:POLR3C POLR3C interactions 1.081E-8 1.249E-7 8.588E-7 5.871E-6 4 44
48 int:ASB6 ASB6 interactions 2.151E-8 2.433E-7 1.673E-6 1.168E-5 4 52
49 int:RPAP1 RPAP1 interactions 2.326E-8 2.577E-7 1.772E-6 1.263E-5 4 53
50 int:POLR3E POLR3E interactions 2.511E-8 2.727E-7 1.875E-6 1.363E-5 4 54
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16q13-q21 16q13-q21 1.269E-3 1.396E-2 4.215E-2 1.396E-2 1 4
2 8q22.2 8q22.2 7.907E-3 3.592E-2
1.085E-1
8.697E-2
 1 25
3 3q28 3q28 9.796E-3 3.592E-2
1.085E-1
1.078E-1
 1 31
4 11p15 11p15 1.482E-2 3.861E-2
1.166E-1
1.630E-1
 1 47
5 4q12 4q12 1.794E-2 3.861E-2
1.166E-1
1.974E-1
 1 57
6 11q13.1 11q13.1 2.106E-2 3.861E-2
1.166E-1
2.317E-1
 1 67
7 22q13.1 22q13.1 2.789E-2 4.383E-2
1.323E-1
3.068E-1
 1 89
8 7q22.1 7q22.1 3.621E-2 4.650E-2
1.404E-1
3.983E-1
 1 116
9 17p13.1 17p13.1 3.805E-2 4.650E-2
1.404E-1
4.185E-1
 1 122
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 49 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 11 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 726 RNA polymerase subunits genenames.org 2.015E-28 4.029E-28 6.044E-28 4.029E-28 10 29

13: Coexpression [Display Chart] 11 input genes in category / 823 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 8.631E-19 7.103E-16 5.179E-15 7.103E-16 9 150
2 M8614 Genes up-regulated in bone marrow-derived dendritic cells: unstimulated versus high dose of 1,3-beta-D-oligoglucan [PubChem=11375554]. MSigDB C7: Immunologic Signatures (v6.0) 9.683E-5 1.026E-2
7.482E-2
7.969E-2
 3 198
3 M3653 Genes down-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after treatment with trichostatin A (TSA) [PubChem=5562]. MSigDB C7: Immunologic Signatures (v6.0) 9.828E-5 1.026E-2
7.482E-2
8.089E-2
 3 199
4 M7651 Genes down-regulated in CD4 [GeneID=920] T cells under specific pathogen free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 9.828E-5 1.026E-2
7.482E-2
8.089E-2
 3 199
5 M5162 Genes up-regulated in comparison of macrophages versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.026E-2
7.482E-2
8.210E-2
 3 200
6 M9477 Genes down-regulated in CD8 T effector cells at day 6 of chronic infection: LCMV-Armstrong versus LCMV-Clone 13. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.026E-2
7.482E-2
8.210E-2
 3 200
7 M7650 Genes up-regulated in CD4 [GeneID=920] T cells under specific pathogen free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.026E-2
7.482E-2
8.210E-2
 3 200
8 M3623 Genes up-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 1.026E-2
7.482E-2
8.210E-2
 3 200
9 16597596-TableS1-4 Human Leukemia Wilson06 50genes SigDifferentialClusterD1 GeneSigDB 1.668E-4 1.274E-2
9.286E-2
1.373E-1
 2 41
10 M18854 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin (sirolimus) [PubChem=6610346] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.817E-4 1.274E-2
9.286E-2
1.496E-1
 3 245
11 16597596-TableS2-4 Human Leukemia Wilson06 50genes DifferentialClusterD GeneSigDB 2.012E-4 1.274E-2
9.286E-2
1.656E-1
 2 45
12 M2536 Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.012E-4 1.274E-2
9.286E-2
1.656E-1
 2 45
13 M19667 Genes down-regulated in HPL1D cells (lung epithelium) upon exposure to nickel acetate [PubChem=9756]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.012E-4 1.274E-2
9.286E-2
1.656E-1
 2 45
14 M1415 Genes whose expression in bone marrow samples correlated directly with increased levels of serum IL5 [GeneID=3567]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.587E-4 1.521E-2
1.109E-1
2.129E-1
 2 51
15 12925741-Figure3 Human Lymphoma Jenner03 75genes GeneSigDB 3.583E-4 1.852E-2
1.350E-1
2.949E-1
 2 60
16 15492233-TableS1 Human Sarcoma Lee04 335genes GeneSigDB 3.803E-4 1.852E-2
1.350E-1
3.130E-1
 3 315
17 M3274 Top up-regulated marker genes for medulloblastoma classification: desmoplastic vs classic morphology. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.826E-4 1.852E-2
1.350E-1
3.149E-1
 2 62
18 M1033 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 10. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.738E-4 2.052E-2
1.496E-1
3.899E-1
 2 69
19 M1507 Up-regulated in hepatocytes upon expression of NOS2 [GeneID=4843]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.738E-4 2.052E-2
1.496E-1
3.899E-1
 2 69
20 19336569-SuppTable3 Human Breast Zhang09 81genes GeneSigDB 5.595E-4 2.303E-2
1.679E-1
4.605E-1
 2 75
21 M17434 Genes up-regulated by forced expression of APC [GeneID=324] in the APC-deficient SW480 cell line (colon cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.897E-4 2.311E-2
1.685E-1
4.853E-1
 2 77
22 M459 Cluster 0: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.134E-3 3.074E-2
2.241E-1
9.333E-1
 2 107
23 M18086 'Cancer prone response profile' (CPRP): genes common to estradiol and bisphenol A [PubChem=5757;6623] response of epithelial cell cultures from patients at high risk of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.376E-3 3.074E-2
2.241E-1
1.000E0
 2 118
24 M17261 Downregulated in the vastus lateralis muscle of aged vs young adult rhesus monkeys MSigDB C2: CGP Curated Gene Sets (v6.0) 1.494E-3 3.074E-2
2.241E-1
1.000E0
 2 123
25 M10633 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.011E-3 3.074E-2
2.241E-1
1.000E0
 2 143
26 M411 Genes down-regulated in T reg: wildtype versus DICER1 [GeneID=23405] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.239E-3 3.074E-2
2.241E-1
1.000E0
 2 151
27 M7115 Genes down-regulated in CD4 [GeneID=920] T cells: control versus treated with halofuginone [PubChem=400772] for 3h. MSigDB C7: Immunologic Signatures (v6.0) 2.448E-3 3.074E-2
2.241E-1
1.000E0
 2 158
28 15471956-Table2 Human Leukemia Sasaki05 192genes GeneSigDB 2.794E-3 3.074E-2
2.241E-1
1.000E0
 2 169
29 M15171 Genes up-regulated in adult T-cell leukemia (ATL) cells compared to T lymphocytes from healthy controls. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.025E-3 3.074E-2
2.241E-1
1.000E0
 2 176
30 M367 Genes down-regulated in macrophages differentiated in the presence of IL4 [GeneID=3565] for 5 days versus those subsequently treated with TGFB1 [GeneID=7040] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 3.335E-3 3.074E-2
2.241E-1
1.000E0
 2 185
31 M5648 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMC from patients with acute S. pneumoniae infection. MSigDB C7: Immunologic Signatures (v6.0) 3.478E-3 3.074E-2
2.241E-1
1.000E0
 2 189
32 M3472 Genes down-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 3.772E-3 3.074E-2
2.241E-1
1.000E0
 2 197
33 M4516 Genes down-regulated in comparison of NK cells stimulated with IL2 [GeneID=3558] at 16 h versus NK cells stimulated with IL15 [GeneID=3600] at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 3.809E-3 3.074E-2
2.241E-1
1.000E0
 2 198
34 M6901 Genes down-regulated in macrophages with IL10 [GeneID=3586] knockout in response to 20 min treatment by: LPS versus LPS and IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v6.0) 3.809E-3 3.074E-2
2.241E-1
1.000E0
 2 198
35 M9721 Genes down-regulated in CD4 [GeneID=920] SMARTA T cells: naïve versus Ly6c low CXCR5- effector during acute infection of LCMV. MSigDB C7: Immunologic Signatures (v6.0) 3.809E-3 3.074E-2
2.241E-1
1.000E0
 2 198
36 M5877 Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
37 M4283 Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
38 M3919 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
39 M3246 Genes down-regulated in comparison of naive B cells versus memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
40 M9959 Genes down-regulated during primary acute viral infection: NK cells versus B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
41 M7254 Genes up-regulated in thymus subcapsular cortical region versus the whole medulla. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
42 M8974 Genes down-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 3.074E-2
2.241E-1
1.000E0
 2 199
43 M8507 Genes down-regulated in CD8 T cells: control versus over-expressing ID3 [GeneID=3399]. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
44 M5281 Genes down-regulated in comparison of eosinophils treated with IL25 [GeneID=64806] versus macrophages treated with IL25 [GeneID=64806]. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
45 M4398 Genes down-regulated in comparison of dendritic cells (DC) treated with CpG DNA (TLR9 agonist) DNA versus the untreated cells. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
46 M5117 Genes up-regulated in comparison of CD8 dendritic cells (DC) versus CD4- [GeneID=920] CD8- DCs. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
47 M4096 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
48 M5157 Genes up-regulated in comparison of macrophages versus macrophages exposed to L.donovani. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
49 M4102 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus those stimulated at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
50 M8648 Genes down-regulated in bone marrow-derived macrophages: control versus stimulated with LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 3.074E-2
2.241E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 378 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal-Medulla Wilms EN-A/Kidney Normal-Medulla Wilms EN2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal-Medulla Wilms EN-A/Kidney Normal-Medulla Wilms EN2 Adult, Development, and Cancer types 5.304E-5 2.005E-2
1.306E-1
 2.005E-2 2 22
2 Podocyte (PD)/Podocyte (PD) b Podocyte (PD)/Podocyte (PD) b 1.066E-4 2.014E-2
1.312E-1
 4.028E-2 3 193
3 Kidney10XCellRanger Six2KI E14 UB UB Subtype E14-Six2KI-UB-C7-KC5 Top 200 Genes Kidney10XCellRanger Six2KI E14 UB UB Subtype E14-Six2KI-UB-C7-KC5 Top 200 Genes 2.453E-4 2.345E-2
1.528E-1
9.274E-2
 3 256
4 Kidney10XCellRanger Six2KI E14 UB UB Top 200 Kidney10XCellRanger Six2KI E14 UB UB Top 200 2.482E-4 2.345E-2
1.528E-1
9.381E-2
 3 257
5 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/mid-fetal/IMM c Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/mid-fetal/IMM c Fetal, Development 4.022E-4 3.040E-2
1.980E-1
1.520E-1
 2 60
6 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2b Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2b Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 5.441E-4 3.428E-2
2.233E-1
2.057E-1
 3 336
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney Normal Wilms EN-D Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-D/Kidney Normal Wilms EN-D Adult, Development, and Cancer types 7.500E-4 4.050E-2
2.638E-1
2.835E-1
 2 82
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter MNP3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter MNP3 Adult, Development, and Cancer types 1.008E-3 4.761E-2
3.101E-1
3.809E-1
 1 2
Show 3 more annotations

15: Computational [Display Chart] 11 input genes in category / 106 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M413 MODULE 273 Phosphate metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.102E-5 1.842E-3 9.664E-3 2.228E-3 3 52
2 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.476E-5 1.842E-3 9.664E-3 3.685E-3 4 187
3 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.136E-4 2.168E-2
1.137E-1
6.504E-2
 4 393

16: MicroRNA [Display Chart] 11 input genes in category / 199 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.383E-4 3.440E-2
2.021E-1
6.732E-2
 2 181
2 hsa-miR-1909-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.458E-4 3.440E-2
2.021E-1
6.881E-2
 2 183

17: Drug [Display Chart] 11 input genes in category / 1412 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005351222 lomofungin Stitch 2.410E-26 2.537E-23 1.986E-22 3.403E-23 9 25
2 CID000148252 S-(6-purinyl)-N-acetyl-L-cysteine Stitch 4.460E-26 2.537E-23 1.986E-22 6.298E-23 10 57
3 CID000002318 benfluorex Stitch 5.389E-26 2.537E-23 1.986E-22 7.610E-23 10 58
4 CID000003165 NSC401575 Stitch 1.206E-25 4.256E-23 3.333E-22 1.703E-22 11 129
5 CID000000766 AC1L19Z8 Stitch 3.510E-25 9.913E-23 7.763E-22 4.957E-22 10 69
6 CID009549278 K00051 Stitch 4.767E-25 1.117E-22 8.743E-22 6.730E-22 10 71
7 CID000068037 6-azauracil Stitch 5.535E-25 1.117E-22 8.743E-22 7.816E-22 10 72
8 CID000449108 AC1L9MQJ Stitch 6.787E-24 1.198E-21 9.380E-21 9.583E-21 8 19
9 CID006540268 II-E Stitch 1.981E-23 3.108E-21 2.434E-20 2.797E-20 10 101
10 CID000000593 NSC20261 Stitch 6.303E-23 8.900E-21 6.969E-20 8.900E-20 11 224
11 CID000002100 alpha-Amanitin Stitch 8.406E-23 1.079E-20 8.449E-20 1.187E-19 10 116
12 CID000115340 AC1L3GYQ Stitch 5.249E-22 5.844E-20 4.576E-19 7.412E-19 8 30
13 CID000327967 AC1L71LQ Stitch 5.484E-22 5.844E-20 4.576E-19 7.743E-19 10 139
14 CID000085040 CPDS Stitch 5.795E-22 5.844E-20 4.576E-19 8.182E-19 9 68
15 CID005359408 AC1NSDZO Stitch 5.864E-21 5.520E-19 4.322E-18 8.279E-18 7 16
16 CID003036909 CTDs Stitch 9.199E-21 8.118E-19 6.357E-18 1.299E-17 9 91
17 CID000072647 anticapsin Stitch 2.581E-20 2.144E-18 1.679E-17 3.645E-17 7 19
18 CID005287969 flavopiridol Stitch 5.061E-20 3.970E-18 3.109E-17 7.146E-17 10 216
19 CID000000193 S-adenosyl-D-homocysteine Stitch 6.693E-20 4.974E-18 3.895E-17 9.451E-17 10 222
20 CID000001181 UTP-NA Stitch 7.138E-20 5.039E-18 3.946E-17 1.008E-16 11 420
21 CID000023989 uranium Stitch 2.434E-19 1.627E-17 1.274E-16 3.437E-16 10 252
22 CID000001102 spermidine Stitch 2.534E-19 1.627E-17 1.274E-16 3.578E-16 10 253
23 CID005381226 rifampicin Stitch 1.748E-18 1.073E-16 8.404E-16 2.469E-15 10 306
24 CID000000761 5'-GMP Na2 Stitch 4.375E-18 2.574E-16 2.016E-15 6.178E-15 10 335
25 CID000007348 Sarkosyl Stitch 5.725E-18 3.234E-16 2.532E-15 8.084E-15 8 88
26 CID000001079 S-adenosylmethionine Stitch 7.867E-18 4.273E-16 3.346E-15 1.111E-14 10 355
27 CID000072957 AC1L2J0W Stitch 1.377E-17 7.203E-16 5.640E-15 1.945E-14 7 42
28 CID000000181 AC1Q68Z5 Stitch 1.834E-17 9.248E-16 7.241E-15 2.589E-14 10 386
29 CID000073432 brusatol Stitch 2.731E-17 1.330E-15 1.041E-14 3.856E-14 7 46
30 CID000008606 captan Stitch 3.208E-17 1.510E-15 1.182E-14 4.530E-14 7 47
31 CID006439007 trans isomer Stitch 9.025E-17 4.031E-15 3.157E-14 1.274E-13 7 54
32 CID006540267 2bq7 Stitch 9.136E-17 4.031E-15 3.157E-14 1.290E-13 8 123
33 CID000119315 8-oxyguanine Stitch 1.440E-16 6.160E-15 4.823E-14 2.033E-13 8 130
34 CID000489933 conta-1(35),3,5,7(37),8,10,12,15,32(36),33-decaene-30-carboxylic acid Stitch 7.486E-16 3.109E-14 2.434E-13 1.057E-12 7 72
35 CID000004545 al-Badry Stitch 1.012E-15 4.084E-14 3.198E-13 1.429E-12 8 165
36 CID000000646 AC1Q6S3Y Stitch 3.786E-15 1.485E-13 1.163E-12 5.346E-12 7 90
37 CID000001652 3-deazacytidine Stitch 6.157E-15 2.350E-13 1.840E-12 8.694E-12 8 206
38 CID000005918 3,4-diaminopyridine Stitch 6.432E-15 2.390E-13 1.872E-12 9.083E-12 6 38
39 CID006439158 AC1O5R3K Stitch 9.341E-15 3.382E-13 2.648E-12 1.319E-11 7 102
40 CID000005097 NSC683246 Stitch 1.730E-14 6.106E-13 4.781E-12 2.442E-11 8 234
41 CID000004461 netropsin Stitch 7.540E-14 2.597E-12 2.033E-11 1.065E-10 6 56
42 CID000001090 selenite Stitch 1.342E-13 4.512E-12 3.533E-11 1.895E-10 7 148
43 CID000000689 AC1Q6S3U Stitch 2.236E-13 7.341E-12 5.748E-11 3.157E-10 7 159
44 CID006386496 AC1O4DJ6 Stitch 2.536E-13 8.138E-12 6.372E-11 3.581E-10 6 68
45 CID005488846 Hs 6 Stitch 2.990E-13 9.383E-12 7.347E-11 4.222E-10 5 23
46 CID005289321 ryu Stitch 5.940E-13 1.823E-11 1.428E-10 8.387E-10 6 78
47 CID000003414 foscarnet Stitch 7.914E-13 2.328E-11 1.823E-10 1.117E-9 7 190
48 CID000005064 NSC-163039 Stitch 7.914E-13 2.328E-11 1.823E-10 1.117E-9 7 190
49 CID000444118 AC1L9FQV Stitch 8.092E-13 2.332E-11 1.826E-10 1.143E-9 6 82
50 CID000001103 spermine Stitch 1.152E-12 3.253E-11 2.548E-10 1.627E-9 8 394
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 125 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0238410 Renal Pelvis Urothelial Carcinoma DisGeNET BeFree 1.480E-3 4.311E-2
2.332E-1
1.850E-1
 1 4
2 C1865371 SEVERE COMBINED IMMUNODEFICIENCY, ATHABASKAN-TYPE DisGeNET Curated 1.480E-3 4.311E-2
2.332E-1
1.850E-1
 1 4
3 C1865322 MIGRAINE, FAMILIAL HEMIPLEGIC, 2 DisGeNET Curated 2.589E-3 4.311E-2
2.332E-1
3.237E-1
 1 7
4 C0854706 Neonatal infection DisGeNET BeFree 2.959E-3 4.311E-2
2.332E-1
3.699E-1
 1 8
5 C1843792 FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED DisGeNET Curated 3.328E-3 4.311E-2
2.332E-1
4.160E-1
 1 9
6 C0271742 Glucocorticoid deficiency with achalasia DisGeNET Curated 3.697E-3 4.311E-2
2.332E-1
4.622E-1
 1 10
7 C1707291 NUT Midline Carcinoma DisGeNET Curated 3.697E-3 4.311E-2
2.332E-1
4.622E-1
 1 10
8 C3494489 Autoimmune polyendocrinopathy syndrome, type 1 DisGeNET Curated 4.067E-3 4.311E-2
2.332E-1
5.083E-1
 1 11
9 C1847987 HUNTINGTON DISEASE-LIKE 2 DisGeNET Curated 4.436E-3 4.311E-2
2.332E-1
5.544E-1
 1 12
10 C0349534 Carcinoma of anal margin DisGeNET BeFree 4.436E-3 4.311E-2
2.332E-1
5.544E-1
 1 12
11 C0040261 Onychomycosis DisGeNET Curated 4.804E-3 4.311E-2
2.332E-1
6.006E-1
 1 13
12 C0019025 Hemoglobin F Disease DisGeNET Curated 4.804E-3 4.311E-2
2.332E-1
6.006E-1
 1 13
13 C1412036 Anal squamous cell carcinoma DisGeNET BeFree 4.804E-3 4.311E-2
2.332E-1
6.006E-1
 1 13
14 C1704981 Hyperparathyroidism-Jaw Tumor Syndrome DisGeNET Curated 5.173E-3 4.311E-2
2.332E-1
6.466E-1
 1 14
15 C0016514 Foot-and-Mouth Disease DisGeNET BeFree 5.173E-3 4.311E-2
2.332E-1
6.466E-1
 1 14
16 C0242383 Age related macular degeneration DisGeNET Curated 6.085E-3 4.754E-2
2.571E-1
7.606E-1
 2 336
Show 11 more annotations