Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc201_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 88 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030332 cyclin binding 2.173E-5 1.912E-3 9.677E-3 1.912E-3 2 23
2 GO:0050816 phosphothreonine residue binding 9.643E-4 3.427E-2
1.734E-1
8.486E-2
 1 3
3 GO:0097027 ubiquitin-protein transferase activator activity 3.211E-3 3.427E-2
1.734E-1
2.826E-1
 1 10
4 GO:0055106 ubiquitin-protein transferase regulator activity 4.814E-3 3.427E-2
1.734E-1
4.236E-1
 1 15
5 GO:0055103 ligase regulator activity 5.134E-3 3.427E-2
1.734E-1
4.518E-1
 1 16
6 GO:0035173 histone kinase activity 6.094E-3 3.427E-2
1.734E-1
5.363E-1
 1 19
7 GO:0004674 protein serine/threonine kinase activity 8.232E-3 3.427E-2
1.734E-1
7.244E-1
 2 452
8 GO:0045309 protein phosphorylated amino acid binding 8.970E-3 3.427E-2
1.734E-1
7.894E-1
 1 28
9 GO:0097472 cyclin-dependent protein kinase activity 1.120E-2 3.427E-2
1.734E-1
9.858E-1
 1 35
10 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1.120E-2 3.427E-2
1.734E-1
9.858E-1
 1 35
11 GO:0019894 kinesin binding 1.343E-2 3.427E-2
1.734E-1
1.000E0
 1 42
12 GO:0051219 phosphoprotein binding 2.482E-2 3.427E-2
1.734E-1
1.000E0
 1 78
13 GO:0051995 Se-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
14 GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
15 GO:0043834 trimethylamine methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
16 GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
17 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
18 GO:0043782 cobalt-precorrin-3 C17-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
19 GO:0043791 dimethylamine methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
20 GO:0043776 cobalt-precorrin-6B C5-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
21 GO:0043803 hydroxyneurosporene-O-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
22 GO:0034931 1-hydroxypyrene methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
23 GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
24 GO:0018707 1-phenanthrol methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
25 GO:0043833 methylamine-specific methylcobalamin:coenzyme M methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
26 GO:0043851 methanol-specific methylcobalamin:coenzyme M methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
27 GO:0016205 selenocysteine methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
28 GO:0051994 P-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
29 GO:0043777 cobalt-precorrin-7 C15-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
30 GO:0016435 rRNA (guanine) methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
31 GO:0043827 tRNA (adenine-57, 58-N(1)-) methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
32 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
33 GO:0052735 tRNA (cytosine-3-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
34 GO:0034933 1-hydroxy-6-methoxypyrene methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
35 GO:0034807 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
36 GO:0080012 trihydroxyferuloyl spermidine O-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
37 GO:0043780 cobalt-precorrin-5B C1-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
38 GO:0034541 dimethylarsinite methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
39 GO:0019702 protein-arginine N5-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
40 GO:0052667 phosphomethylethanolamine N-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
41 GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
42 GO:0052624 2-phytyl-1,4-naphthoquinone methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
43 GO:0043770 demethylmenaquinone methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
44 GO:0043852 monomethylamine methyltransferase activity 2.514E-2 3.427E-2
1.734E-1
1.000E0
 1 79
45 GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity 2.545E-2 3.427E-2
1.734E-1
1.000E0
 1 80
46 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity 2.545E-2 3.427E-2
1.734E-1
1.000E0
 1 80
47 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity 2.545E-2 3.427E-2
1.734E-1
1.000E0
 1 80
48 GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity 2.545E-2 3.427E-2
1.734E-1
1.000E0
 1 80
49 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity 2.545E-2 3.427E-2
1.734E-1
1.000E0
 1 80
50 GO:0016434 rRNA (cytosine) methyltransferase activity 2.545E-2 3.427E-2
1.734E-1
1.000E0
 1 80
Show 45 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 335 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031023 microtubule organizing center organization 5.275E-6 1.767E-3 1.130E-2 1.767E-3 3 121
2 GO:0007099 centriole replication 3.258E-5 4.473E-3 2.860E-2 1.091E-2 2 28
3 GO:0098534 centriole assembly 4.006E-5 4.473E-3 2.860E-2 1.342E-2 2 31
4 GO:0090329 regulation of DNA-dependent DNA replication 8.511E-5 7.128E-3 4.557E-2 2.851E-2 2 45
5 GO:0051298 centrosome duplication 1.675E-4 1.122E-2
7.173E-2
5.610E-2
 2 63
6 GO:0007098 centrosome cycle 2.703E-4 1.199E-2
7.667E-2
9.056E-2
 2 80
7 GO:0000226 microtubule cytoskeleton organization 2.906E-4 1.199E-2
7.667E-2
9.735E-2
 3 464
8 GO:2000638 regulation of SREBP signaling pathway 3.222E-4 1.199E-2
7.667E-2
1.079E-1
 1 1
9 GO:2000639 negative regulation of SREBP signaling pathway 3.222E-4 1.199E-2
7.667E-2
1.079E-1
 1 1
10 GO:0051438 regulation of ubiquitin-protein transferase activity 6.073E-4 1.542E-2
9.856E-2
2.034E-1
 2 120
11 GO:0051340 regulation of ligase activity 6.379E-4 1.542E-2
9.856E-2
2.137E-1
 2 123
12 GO:0032298 positive regulation of DNA-dependent DNA replication initiation 6.443E-4 1.542E-2
9.856E-2
2.158E-1
 1 2
13 GO:0046601 positive regulation of centriole replication 6.443E-4 1.542E-2
9.856E-2
2.158E-1
 1 2
14 GO:0010868 negative regulation of triglyceride biosynthetic process 6.443E-4 1.542E-2
9.856E-2
2.158E-1
 1 2
15 GO:0006261 DNA-dependent DNA replication 7.564E-4 1.689E-2
1.080E-1
2.534E-1
 2 134
16 GO:0032053 ciliary basal body organization 9.663E-4 1.904E-2
1.217E-1
3.237E-1
 1 3
17 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 9.663E-4 1.904E-2
1.217E-1
3.237E-1
 1 3
18 GO:1902806 regulation of cell cycle G1/S phase transition 1.023E-3 1.904E-2
1.217E-1
3.427E-1
 2 156
19 GO:0006275 regulation of DNA replication 1.241E-3 2.092E-2
1.338E-1
4.159E-1
 2 172
20 GO:1903223 positive regulation of oxidative stress-induced neuron death 1.288E-3 2.092E-2
1.338E-1
4.316E-1
 1 4
21 GO:0010825 positive regulation of centrosome duplication 1.610E-3 2.092E-2
1.338E-1
5.394E-1
 1 5
22 GO:2000346 negative regulation of hepatocyte proliferation 1.610E-3 2.092E-2
1.338E-1
5.394E-1
 1 5
23 GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 1.610E-3 2.092E-2
1.338E-1
5.394E-1
 1 5
24 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding 1.610E-3 2.092E-2
1.338E-1
5.394E-1
 1 5
25 GO:0032876 negative regulation of DNA endoreduplication 1.610E-3 2.092E-2
1.338E-1
5.394E-1
 1 5
26 GO:0000086 G2/M transition of mitotic cell cycle 1.624E-3 2.092E-2
1.338E-1
5.440E-1
 2 197
27 GO:0044839 cell cycle G2/M phase transition 1.757E-3 2.108E-2
1.347E-1
5.886E-1
 2 205
28 GO:0030174 regulation of DNA-dependent DNA replication initiation 1.932E-3 2.108E-2
1.347E-1
6.472E-1
 1 6
29 GO:0046607 positive regulation of centrosome cycle 1.932E-3 2.108E-2
1.347E-1
6.472E-1
 1 6
30 GO:0030324 lung development 2.038E-3 2.108E-2
1.347E-1
6.827E-1
 2 221
31 GO:0030323 respiratory tube development 2.111E-3 2.108E-2
1.347E-1
7.073E-1
 2 225
32 GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2.253E-3 2.108E-2
1.347E-1
7.549E-1
 1 7
33 GO:0010948 negative regulation of cell cycle process 2.398E-3 2.108E-2
1.347E-1
8.032E-1
 2 240
34 GO:0034599 cellular response to oxidative stress 2.537E-3 2.108E-2
1.347E-1
8.500E-1
 2 247
35 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 2.575E-3 2.108E-2
1.347E-1
8.626E-1
 1 8
36 GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 2.575E-3 2.108E-2
1.347E-1
8.626E-1
 1 8
37 GO:0010457 centriole-centriole cohesion 2.575E-3 2.108E-2
1.347E-1
8.626E-1
 1 8
38 GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress 2.575E-3 2.108E-2
1.347E-1
8.626E-1
 1 8
39 GO:0032875 regulation of DNA endoreduplication 2.575E-3 2.108E-2
1.347E-1
8.626E-1
 1 8
40 GO:0060541 respiratory system development 2.681E-3 2.108E-2
1.347E-1
8.980E-1
 2 254
41 GO:0044843 cell cycle G1/S phase transition 2.743E-3 2.108E-2
1.347E-1
9.190E-1
 2 257
42 GO:0090068 positive regulation of cell cycle process 2.786E-3 2.108E-2
1.347E-1
9.331E-1
 2 259
43 GO:0071501 cellular response to sterol depletion 2.897E-3 2.108E-2
1.347E-1
9.703E-1
 1 9
44 GO:0090209 negative regulation of triglyceride metabolic process 2.897E-3 2.108E-2
1.347E-1
9.703E-1
 1 9
45 GO:0042023 DNA endoreduplication 2.897E-3 2.108E-2
1.347E-1
9.703E-1
 1 9
46 GO:0032933 SREBP signaling pathway 2.897E-3 2.108E-2
1.347E-1
9.703E-1
 1 9
47 GO:0031396 regulation of protein ubiquitination 2.957E-3 2.108E-2
1.347E-1
9.907E-1
 2 267
48 GO:0006991 response to sterol depletion 3.218E-3 2.246E-2
1.436E-1
1.000E0
 1 10
49 GO:1903320 regulation of protein modification by small protein conjugation or removal 3.478E-3 2.371E-2
1.516E-1
1.000E0
 2 290
50 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 3.539E-3 2.371E-2
1.516E-1
1.000E0
 1 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 29 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000803 sex chromosome 4.079E-5 1.183E-3 4.686E-3 1.183E-3 2 32
2 GO:0005814 centriole 4.444E-4 5.476E-3 2.169E-2 1.289E-2 2 105
3 GO:0000806 Y chromosome 6.295E-4 5.476E-3 2.169E-2 1.825E-2 1 2
4 GO:0044450 microtubule organizing center part 8.683E-4 5.476E-3 2.169E-2 2.518E-2 2 147
5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex 9.441E-4 5.476E-3 2.169E-2 2.738E-2 1 3
6 GO:0098536 deuterosome 1.573E-3 7.603E-3 3.012E-2 4.562E-2 1 5
7 GO:0000805 X chromosome 2.516E-3 1.042E-2 4.129E-2
7.296E-2
 1 8
8 GO:0035253 ciliary rootlet 3.144E-3 1.140E-2 4.515E-2
9.118E-2
 1 10
9 GO:0001741 XY body 5.340E-3 1.721E-2
6.817E-2
1.549E-1
 1 17
10 GO:0000307 cyclin-dependent protein kinase holoenzyme complex 1.003E-2 2.909E-2
1.153E-1
2.909E-1
 1 32
11 GO:0019005 SCF ubiquitin ligase complex 1.128E-2 2.974E-2
1.178E-1
3.271E-1
 1 36
12 GO:0001917 photoreceptor inner segment 1.439E-2 3.038E-2
1.204E-1
4.174E-1
 1 46
13 GO:0032154 cleavage furrow 1.533E-2 3.038E-2
1.204E-1
4.445E-1
 1 49
14 GO:0097610 cell surface furrow 1.533E-2 3.038E-2
1.204E-1
4.445E-1
 1 49
15 GO:0015030 Cajal body 1.688E-2 3.038E-2
1.204E-1
4.895E-1
 1 54
16 GO:0032153 cell division site 1.781E-2 3.038E-2
1.204E-1
5.165E-1
 1 57
17 GO:0032155 cell division site part 1.781E-2 3.038E-2
1.204E-1
5.165E-1
 1 57
18 GO:1902554 serine/threonine protein kinase complex 2.523E-2 4.065E-2
1.610E-1
7.317E-1
 1 81
19 GO:1902911 protein kinase complex 2.862E-2 4.368E-2
1.730E-1
8.299E-1
 1 92
Show 14 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 180 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 253 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 73 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR031341 Methyltr RsmF N InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
2 PF17125 Methyltr RsmF N Pfam 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
3 PF08062 P120R Pfam 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
4 IPR026733 Rootletin InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
5 IPR033698 POLO box Plk4 2 InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
6 IPR033699 POLO box Plk4 1 InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
7 IPR023273 RCMT NOP2 InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
8 IPR033700 Plk4 InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
9 IPR012586 P120R rpt InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
10 IPR011023 Nop2p InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
11 IPR033696 POLO box Plk4 C InterPro 3.203E-4 2.125E-3 1.036E-2 2.338E-2 1 1
12 IPR018314 Fmu/NOL1/Nop2p CS InterPro 6.404E-4 3.117E-3 1.519E-2 4.675E-2 1 2
13 PS51302 SIM C PROSITE 6.404E-4 3.117E-3 1.519E-2 4.675E-2 1 2
14 PF06621 SIM C Pfam 6.404E-4 3.117E-3 1.519E-2 4.675E-2 1 2
15 IPR010578 SIM C InterPro 6.404E-4 3.117E-3 1.519E-2 4.675E-2 1 2
16 PS50078 POLO BOX PROSITE 1.281E-3 5.499E-3 2.680E-2
9.348E-2
 1 4
17 PF00659 POLO box Pfam 1.281E-3 5.499E-3 2.680E-2
9.348E-2
 1 4
18 IPR000959 POLO box dom InterPro 1.600E-3 6.491E-3 3.164E-2
1.168E-1
 1 5
19 PS01153 NOL1 NOP2 SUN PROSITE 1.920E-3 7.009E-3 3.417E-2
1.402E-1
 1 6
20 IPR023267 RCMT InterPro 1.920E-3 7.009E-3 3.417E-2
1.402E-1
 1 6
21 PS51686 SAM MT RSMB NOP PROSITE 2.240E-3 7.786E-3 3.795E-2
1.635E-1
 1 7
22 IPR001067 Nuc translocat InterPro 2.560E-3 7.786E-3 3.795E-2
1.869E-1
 1 8
23 IPR001678 MeTrfase RsmB/NOP2 InterPro 2.560E-3 7.786E-3 3.795E-2
1.869E-1
 1 8
24 PF01189 Methyltr RsmB-F Pfam 2.560E-3 7.786E-3 3.795E-2
1.869E-1
 1 8
25 SM00220 S TKc SMART 5.219E-3 1.489E-2
7.260E-2
3.810E-1
 2 359
26 PS00108 PROTEIN KINASE ST PROSITE 5.305E-3 1.489E-2
7.260E-2
3.873E-1
 2 362
27 IPR017441 Protein kinase ATP BS InterPro 5.801E-3 1.528E-2
7.449E-2
4.235E-1
 2 379
28 PF00069 Pkinase Pfam 5.861E-3 1.528E-2
7.449E-2
4.279E-1
 2 381
29 PF08447 PAS 3 Pfam 7.344E-3 1.617E-2
7.881E-2
5.361E-1
 1 23
30 IPR013655 PAS fold 3 InterPro 7.344E-3 1.617E-2
7.881E-2
5.361E-1
 1 23
31 IPR010978 tRNA-bd arm InterPro 7.663E-3 1.617E-2
7.881E-2
5.594E-1
 1 24
32 IPR000700 PAS-assoc C InterPro 7.663E-3 1.617E-2
7.881E-2
5.594E-1
 1 24
33 IPR013767 PAS fold InterPro 7.981E-3 1.617E-2
7.881E-2
5.826E-1
 1 25
34 PF00989 PAS Pfam 7.981E-3 1.617E-2
7.881E-2
5.826E-1
 1 25
35 IPR001610 PAC InterPro 8.299E-3 1.617E-2
7.881E-2
6.058E-1
 1 26
36 PS50113 PAC PROSITE 8.299E-3 1.617E-2
7.881E-2
6.058E-1
 1 26
37 SM00086 PAC SMART 8.299E-3 1.617E-2
7.881E-2
6.058E-1
 1 26
38 PS00107 PROTEIN KINASE ATP PROSITE 8.416E-3 1.617E-2
7.881E-2
6.143E-1
 2 459
39 IPR000719 Prot kinase dom InterPro 9.512E-3 1.763E-2
8.596E-2
6.944E-1
 2 489
40 PS50011 PROTEIN KINASE DOM PROSITE 9.663E-3 1.763E-2
8.596E-2
7.054E-1
 2 493
41 SM00091 PAS SMART 1.021E-2 1.817E-2
8.858E-2
7.450E-1
 1 32
42 PS50112 PAS PROSITE 1.084E-2 1.840E-2
8.971E-2
7.914E-1
 1 34
43 IPR000014 PAS InterPro 1.084E-2 1.840E-2
8.971E-2
7.914E-1
 1 34
44 PF12937 F-box-like Pfam 1.401E-2 2.324E-2
1.133E-1
1.000E0
 1 44
45 SM00256 FBOX SMART 1.654E-2 2.683E-2
1.308E-1
1.000E0
 1 52
46 PF00646 F-box Pfam 2.127E-2 3.375E-2
1.645E-1
1.000E0
 1 67
47 IPR020636 Ca/CaM-dep Ca-dep prot Kinase InterPro 2.190E-2 3.401E-2
1.658E-1
1.000E0
 1 69
48 IPR009053 Prefoldin InterPro 2.284E-2 3.403E-2
1.659E-1
1.000E0
 1 72
49 PS50181 FBOX PROSITE 2.284E-2 3.403E-2
1.659E-1
1.000E0
 1 72
50 IPR001810 F-box dom InterPro 2.378E-2 3.472E-2
1.693E-1
1.000E0
 1 75
Show 45 more annotations

7: Pathway [Display Chart] 4 input genes in category / 125 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138079 PLK2 and PLK4 events BioSystems: Pathway Interaction Database 6.425E-4 2.007E-2
1.086E-1
8.031E-2
 1 2
2 921162 FoxO signaling pathway BioSystems: KEGG 6.601E-4 2.007E-2
1.086E-1
8.252E-2
 2 132
3 1269799 G2/M Transition BioSystems: REACTOME 1.278E-3 2.007E-2
1.086E-1
1.598E-1
 2 184
4 1269771 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes BioSystems: REACTOME 1.285E-3 2.007E-2
1.086E-1
1.606E-1
 1 4
5 138077 Polo-like kinase signaling events in the cell cycle BioSystems: Pathway Interaction Database 1.285E-3 2.007E-2
1.086E-1
1.606E-1
 1 4
6 1269797 Mitotic G2-G2/M phases BioSystems: REACTOME 1.306E-3 2.007E-2
1.086E-1
1.632E-1
 2 186
7 1269798 G2 Phase BioSystems: REACTOME 1.606E-3 2.007E-2
1.086E-1
2.007E-1
 1 5
8 1427844 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation BioSystems: REACTOME 1.606E-3 2.007E-2
1.086E-1
2.007E-1
 1 5
9 1268892 FBXW7 Mutants and NOTCH1 in Cancer BioSystems: REACTOME 1.606E-3 2.007E-2
1.086E-1
2.007E-1
 1 5
10 1268893 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling BioSystems: REACTOME 1.606E-3 2.007E-2
1.086E-1
2.007E-1
 1 5
11 1383028 PTK6 Regulates Cell Cycle BioSystems: REACTOME 1.927E-3 2.189E-2
1.184E-1
2.408E-1
 1 6
12 M6031 E2F1 Destruction Pathway MSigDB C2 BIOCARTA (v6.0) 3.209E-3 3.258E-2
1.763E-1
4.012E-1
 1 10
13 1383072 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest BioSystems: REACTOME 4.171E-3 3.258E-2
1.763E-1
5.213E-1
 1 13
14 M3686 Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. MSigDB C2 BIOCARTA (v6.0) 4.171E-3 3.258E-2
1.763E-1
5.213E-1
 1 13
15 M17977 Regulation of p27 Phosphorylation during Cell Cycle Progression MSigDB C2 BIOCARTA (v6.0) 4.171E-3 3.258E-2
1.763E-1
5.213E-1
 1 13
16 M18159 RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage MSigDB C2 BIOCARTA (v6.0) 4.171E-3 3.258E-2
1.763E-1
5.213E-1
 1 13
17 M1529 Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. MSigDB C2 BIOCARTA (v6.0) 4.811E-3 3.538E-2
1.914E-1
6.014E-1
 1 15
18 M14863 p53 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 5.131E-3 3.563E-2
1.928E-1
6.414E-1
 1 16
19 M6682 CDK Regulation of DNA Replication MSigDB C2 BIOCARTA (v6.0) 5.771E-3 3.797E-2
2.054E-1
7.214E-1
 1 18
20 1269800 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 7.050E-3 4.187E-2
2.265E-1
8.813E-1
 1 22
21 M17770 Cyclins and Cell Cycle Regulation MSigDB C2 BIOCARTA (v6.0) 7.370E-3 4.187E-2
2.265E-1
9.212E-1
 1 23
22 137969 Signaling events mediated by PRL BioSystems: Pathway Interaction Database 7.370E-3 4.187E-2
2.265E-1
9.212E-1
 1 23
23 1269765 G0 and Early G1 BioSystems: REACTOME 8.009E-3 4.308E-2
2.331E-1
1.000E0
 1 25
24 M14512 Influence of Ras and Rho proteins on G1 to S Transition MSigDB C2 BIOCARTA (v6.0) 8.328E-3 4.308E-2
2.331E-1
1.000E0
 1 26
25 M648 Cell Cycle: G1/S Check Point MSigDB C2 BIOCARTA (v6.0) 8.967E-3 4.308E-2
2.331E-1
1.000E0
 1 28
26 137959 BARD1 signaling events BioSystems: Pathway Interaction Database 9.286E-3 4.308E-2
2.331E-1
1.000E0
 1 29
27 1269773 Activation of the pre-replicative complex BioSystems: REACTOME 1.024E-2 4.308E-2
2.331E-1
1.000E0
 1 32
28 1383079 Regulation of TP53 Degradation BioSystems: REACTOME 1.120E-2 4.308E-2
2.331E-1
1.000E0
 1 35
29 1383077 Regulation of TP53 Expression and Degradation BioSystems: REACTOME 1.152E-2 4.308E-2
2.331E-1
1.000E0
 1 36
30 137935 FOXM1 transcription factor network BioSystems: Pathway Interaction Database 1.184E-2 4.308E-2
2.331E-1
1.000E0
 1 37
31 P00045 Notch signaling pathway PantherDB 1.184E-2 4.308E-2
2.331E-1
1.000E0
 1 37
32 1269757 Activation of ATR in response to replication stress BioSystems: REACTOME 1.184E-2 4.308E-2
2.331E-1
1.000E0
 1 37
33 1427839 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors BioSystems: REACTOME 1.279E-2 4.308E-2
2.331E-1
1.000E0
 1 40
34 1268699 Association of TriC/CCT with target proteins during biosynthesis BioSystems: REACTOME 1.279E-2 4.308E-2
2.331E-1
1.000E0
 1 40
35 M9526 T Cell Signal Transduction MSigDB C2 BIOCARTA (v6.0) 1.438E-2 4.308E-2
2.331E-1
1.000E0
 1 45
36 P04398 p53 pathway feedback loops 2 PantherDB 1.438E-2 4.308E-2
2.331E-1
1.000E0
 1 45
37 138036 FoxO family signaling BioSystems: Pathway Interaction Database 1.533E-2 4.308E-2
2.331E-1
1.000E0
 1 48
38 1269537 NOTCH1 Intracellular Domain Regulates Transcription BioSystems: REACTOME 1.533E-2 4.308E-2
2.331E-1
1.000E0
 1 48
39 1383071 TP53 Regulates Transcription of Cell Cycle Genes BioSystems: REACTOME 1.565E-2 4.308E-2
2.331E-1
1.000E0
 1 49
40 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 1.660E-2 4.308E-2
2.331E-1
1.000E0
 1 52
41 1269783 CDK-mediated phosphorylation and removal of Cdc6 BioSystems: REACTOME 1.724E-2 4.308E-2
2.331E-1
1.000E0
 1 54
42 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 1.787E-2 4.308E-2
2.331E-1
1.000E0
 1 56
43 1268889 Constitutive Signaling by NOTCH1 PEST Domain Mutants BioSystems: REACTOME 1.851E-2 4.308E-2
2.331E-1
1.000E0
 1 58
44 1268890 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer BioSystems: REACTOME 1.851E-2 4.308E-2
2.331E-1
1.000E0
 1 58
45 1268888 Signaling by NOTCH1 PEST Domain Mutants in Cancer BioSystems: REACTOME 1.851E-2 4.308E-2
2.331E-1
1.000E0
 1 58
46 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 1.851E-2 4.308E-2
2.331E-1
1.000E0
 1 58
47 1268883 Signaling by NOTCH1 in Cancer BioSystems: REACTOME 1.851E-2 4.308E-2
2.331E-1
1.000E0
 1 58
48 1268891 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants BioSystems: REACTOME 1.851E-2 4.308E-2
2.331E-1
1.000E0
 1 58
49 138067 p53 pathway BioSystems: Pathway Interaction Database 1.882E-2 4.308E-2
2.331E-1
1.000E0
 1 59
50 138001 mTOR signaling pathway BioSystems: Pathway Interaction Database 1.946E-2 4.308E-2
2.331E-1
1.000E0
 1 61
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1636 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18559665 Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. Pubmed 6.170E-8 4.037E-5 3.221E-4 1.009E-4 2 3
2 28760857 FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Pubmed 6.170E-8 4.037E-5 3.221E-4 1.009E-4 2 3
3 14536078 Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Pubmed 1.234E-7 4.037E-5 3.221E-4 2.019E-4 2 4
4 24820417 Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Pubmed 1.234E-7 4.037E-5 3.221E-4 2.019E-4 2 4
5 23082202 The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ. Pubmed 1.234E-7 4.037E-5 3.221E-4 2.019E-4 2 4
6 19423708 Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. Pubmed 2.056E-7 5.607E-5 4.473E-4 3.364E-4 2 5
7 23670162 Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Pubmed 4.318E-7 1.009E-4 8.050E-4 7.063E-4 2 7
8 14672936 Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. Pubmed 2.158E-6 4.412E-4 3.520E-3 3.530E-3 2 15
9 20508983 Centrosome-related genes, genetic variation, and risk of breast cancer. Pubmed 1.052E-4 8.385E-4 6.689E-3
1.721E-1
 2 102
10 19124506 Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Pubmed 1.384E-4 8.385E-4 6.689E-3
2.265E-1
 2 117
11 15611077 Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
12 16484282 Differential transcriptional regulation by mouse single-minded 2s. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
13 8510751 Crystal structure of cyclin-dependent kinase 2. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
14 11781834 Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
15 18094723 FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
16 26774344 Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
17 3422591 Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
18 11301255 Late mitotic failure in mice lacking Sak, a polo-like kinase. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
19 12352953 The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
20 25320347 Mutation in PLK4, encoding a master regulator of centriole formation, defines a novel locus for primordial dwarfism. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
21 8661114 The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
22 28422719 Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
23 12203729 Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
24 29427302 Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
25 16129820 Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
26 17013093 Cyclin-dependent kinase 2 expression in human melanomas and benign melanocytic skin lesions. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
27 25918937 Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
28 25481415 Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
29 24981932 PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
30 18414042 Both SCF(Cdc4alpha) and SCF(Cdc4gamma) are required for cyclin E turnover in cell lines that do not overexpress cyclin E. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
31 25955728 HSA21 Single-Minded 2 (Sim2) Binding Sites Co-Localize with Super-Enhancers and Pioneer Transcription Factors in Pluripotent Mouse ES Cells. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
32 26481051 PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
33 11506705 The long form of CDK2 arises via alternative splicing and forms an active protein kinase with cyclins A and E. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
34 17942901 Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
35 28424412 FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
36 29097832 Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
37 21324136 Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
38 27486687 FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
39 17320938 Low frequency of hCDC4 mutations in human primary ovarian cancer. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
40 22848434 Fbxw7 controls angiogenesis by regulating endothelial Notch activity. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
41 19737960 Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
42 23558291 Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
43 15309028 The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
44 17631934 Iron chelators ICL670 and 311 inhibit HIV-1 transcription. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
45 10075979 The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
46 26755742 A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
47 29373224 Analysis of CDK2 mutations in Chinese men with non-obstructive azoospermia who underwent testis biopsy. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
48 25319570 Ethanol Activation of PKA Mediates Single-Minded 2 Expression in Neuronal Cells. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
49 18367647 Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
50 24075009 The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Pubmed 1.571E-4 8.385E-4 6.689E-3
2.570E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 1120 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:STOML1 STOML1 interactions 2.009E-6 2.250E-3 1.710E-2 2.250E-3 2 7
2 int:CCNE2 CCNE2 interactions 1.461E-5 8.182E-3
6.218E-2
 1.636E-2 2 18
3 int:CDX2 CDX2 interactions 3.604E-5 1.197E-2
9.097E-2
 4.037E-2 2 28
4 int:SRBD1 SRBD1 interactions 5.031E-5 1.197E-2
9.097E-2
5.635E-2
 2 33
5 int:EGLN2 EGLN2 interactions 5.345E-5 1.197E-2
9.097E-2
5.986E-2
 2 34
6 int:GATA3 GATA3 interactions 6.693E-5 1.249E-2
9.494E-2
7.497E-2
 2 38
7 int:EZH2 EZH2 interactions 1.276E-4 1.903E-2
1.446E-1
1.429E-1
 3 334
8 int:GATA2 GATA2 interactions 1.359E-4 1.903E-2
1.446E-1
1.522E-1
 2 54
9 int:CCND3 CCND3 interactions 2.159E-4 2.194E-2
1.667E-1
2.418E-1
 2 68
10 int:FOXM1 FOXM1 interactions 2.698E-4 2.194E-2
1.667E-1
3.022E-1
 2 76
11 int:RBM28 RBM28 interactions 3.065E-4 2.194E-2
1.667E-1
3.433E-1
 2 81
12 int:MYO5A MYO5A interactions 3.141E-4 2.194E-2
1.667E-1
3.518E-1
 2 82
13 int:TTK TTK interactions 3.218E-4 2.194E-2
1.667E-1
3.604E-1
 2 83
14 int:CEBPZ CEBPZ interactions 3.375E-4 2.194E-2
1.667E-1
3.780E-1
 2 85
15 int:RPL10L RPL10L interactions 3.536E-4 2.194E-2
1.667E-1
3.960E-1
 2 87
16 int:DOCK7 DOCK7 interactions 3.953E-4 2.194E-2
1.667E-1
4.428E-1
 2 92
17 int:CCNE1 CCNE1 interactions 4.953E-4 2.194E-2
1.667E-1
5.547E-1
 2 103
18 int:HADHA HADHA interactions 4.953E-4 2.194E-2
1.667E-1
5.547E-1
 2 103
19 int:H2AFY2 H2AFY2 interactions 5.049E-4 2.194E-2
1.667E-1
5.655E-1
 2 104
20 int:ARHGDIA ARHGDIA interactions 5.646E-4 2.194E-2
1.667E-1
6.324E-1
 2 110
21 int:SSBP1 SSBP1 interactions 6.276E-4 2.194E-2
1.667E-1
7.030E-1
 2 116
22 int:NUDT4B NUDT4B interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
23 int:SPAG11B SPAG11B interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
24 int:UBE2QL1 UBE2QL1 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
25 int:NAT8B NAT8B interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
26 int:TUBBP2 TUBBP2 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
27 int:OR51V1 OR51V1 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
28 int:SHROOM4 SHROOM4 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
29 int:MT1E MT1E interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
30 int:LINC00173 LINC00173 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
31 int:C8orf44 C8orf44 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
32 int:GAMTP1 GAMTP1 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
33 int:WDR97 WDR97 interactions 6.778E-4 2.194E-2
1.667E-1
7.591E-1
 1 2
34 int:TMOD3 TMOD3 interactions 7.053E-4 2.194E-2
1.667E-1
7.899E-1
 2 123
35 int:HIST1H1E HIST1H1E interactions 7.167E-4 2.194E-2
1.667E-1
8.027E-1
 2 124
36 int:TPM1 TPM1 interactions 7.516E-4 2.194E-2
1.667E-1
8.418E-1
 2 127
37 int:EIF3E EIF3E interactions 7.634E-4 2.194E-2
1.667E-1
8.551E-1
 2 128
38 int:TOP2A TOP2A interactions 8.487E-4 2.194E-2
1.667E-1
9.505E-1
 2 135
39 int:MAGED1 MAGED1 interactions 8.866E-4 2.194E-2
1.667E-1
9.929E-1
 2 138
40 int:SORT1 SORT1 interactions 8.994E-4 2.194E-2
1.667E-1
1.000E0
 2 139
41 int:EBNA1BP2 EBNA1BP2 interactions 9.123E-4 2.194E-2
1.667E-1
1.000E0
 2 140
42 int:CNBP CNBP interactions 9.915E-4 2.194E-2
1.667E-1
1.000E0
 2 146
43 int:LETM2 LETM2 interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
44 int:CCNB3 CCNB3 interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
45 int:LOC100419906 LOC100419906 interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
46 int:RERG RERG interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
47 int:MMAA MMAA interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
48 int:MT1F MT1F interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
49 int:MS4A3 MS4A3 interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
50 int:TXLNGY TXLNGY interactions 1.016E-3 2.194E-2
1.667E-1
1.000E0
 1 3
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q28 4q28 1.557E-3 8.818E-3 2.160E-2 9.342E-3 1 9
2 21q22.13 21q22.13 2.939E-3 8.818E-3 2.160E-2 1.764E-2 1 17
3 4q31.3 4q31.3 5.355E-3 1.071E-2 2.624E-2 3.213E-2 1 31
4 12p13 12p13 1.137E-2 1.223E-2 2.996E-2
6.823E-2
 1 66
5 1p36.13 1p36.13 1.171E-2 1.223E-2 2.996E-2
7.029E-2
 1 68
6 12q13 12q13 1.223E-2 1.223E-2 2.996E-2
7.337E-2
 1 71
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 81 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 664 NOP2/Sun RNA methyltransferase family genenames.org 1.538E-3 6.041E-3 1.379E-2 7.691E-3 1 7
2 559 WD repeat domain containing|F-box and WD repeat domain containing genenames.org 2.416E-3 6.041E-3 1.379E-2 1.208E-2 1 11
3 496 Cyclin dependent kinases genenames.org 5.704E-3 9.507E-3 2.171E-2 2.852E-2 1 26
4 420 Basic helix-loop-helix proteins genenames.org 2.397E-2 2.996E-2
6.841E-2
1.198E-1
 1 110

13: Coexpression [Display Chart] 6 input genes in category / 719 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2965 Genes down-regulated in T conv versus induced T reg with non-functional FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 9.566E-6 6.878E-3 4.922E-2 6.878E-3 3 183
2 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.195E-5 2.206E-2
1.579E-1
 4.454E-2 3 342
3 M5928 A subgroup of genes regulated by MYC - version 2 (v2). MSigDB H: Hallmark Gene Sets (v6.0) 9.204E-5 2.206E-2
1.579E-1
6.618E-2
 2 58
4 M4752 Genes down-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.322E-4 2.474E-2
1.770E-1
1.669E-1
 2 92
5 M13108 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.263E-4 2.474E-2
1.770E-1
5.222E-1
 2 163
6 19261849-TableS4b Human Endometrial Salvesen09 13genes GeneSigDB 7.778E-4 2.474E-2
1.770E-1
5.592E-1
 1 3
7 M4288 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.845E-4 2.474E-2
1.770E-1
6.360E-1
 2 180
8 M374 Genes up-regulated in B lymphocytes: naïve versus memory. MSigDB C7: Immunologic Signatures (v6.0) 9.041E-4 2.474E-2
1.770E-1
6.501E-1
 2 182
9 M6807 Genes up-regulated in B lymphocytes treated by anti-HEL and expressing BCR [GeneID=613] fusions with: IgM versus IgMG. MSigDB C7: Immunologic Signatures (v6.0) 9.440E-4 2.474E-2
1.770E-1
6.787E-1
 2 186
10 16585155-TableS1 Human Colon Watanabe06 214genes GeneSigDB 1.005E-3 2.474E-2
1.770E-1
7.228E-1
 2 192
11 M4216 Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h versus the untreated cells at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 1.047E-3 2.474E-2
1.770E-1
7.530E-1
 2 196
12 M8345 Genes down-regulated in activated versus induced T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 1.047E-3 2.474E-2
1.770E-1
7.530E-1
 2 196
13 M7458 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: medium versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.474E-2
1.770E-1
7.606E-1
 2 197
14 M4728 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.474E-2
1.770E-1
7.683E-1
 2 198
15 M6104 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.474E-2
1.770E-1
7.683E-1
 2 198
16 M5723 Genes up-regulated in comparison of NK cells treated with IL15 [GeneID=3567] versus untreated NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.474E-2
1.770E-1
7.760E-1
 2 199
17 M3027 Genes up-regulated in comparison of naive versus memory CD8 T cells (day 40+ following LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.474E-2
1.770E-1
7.760E-1
 2 199
18 M6033 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (48h) versus untreated (48h). MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.474E-2
1.770E-1
7.760E-1
 2 199
19 M9410 Genes up-regulated in NK cells: untreated versus poly(IC). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
20 M9486 Genes down-regulated in CD8 T effector cells during chronic infection with LCMV-Clone 13: day 6 versus day 8. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
21 M3591 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with IL12 . MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
22 M3830 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
23 M9523 Genes up-regulated in CD5 T cells at acute infection with LCMV-Armstrong: effectors at day 15 versus memory at day 30. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
24 M8332 Genes down-regulated in BCL6 [GeneID=604] low follicular helper T cells versus T conv cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
25 M3059 Genes down-regulated in comparison of memory CD8 T cells versus effector CD8 T cells KLRG1 intermediate [GeneID=10219]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
26 M9542 Genes up-regulated in macrophages: resting versus stimulated by IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
27 M6065 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 [GeneID=7040] and IL-12 (6h) versus IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
28 M9384 Genes up-regulated in day 7 plasma cells versus day 40 memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
29 M3594 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with antigen-B7-1. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
30 M9419 Genes up-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
31 M3588 Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.474E-2
1.770E-1
7.838E-1
 2 200
32 M14340 Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.101E-3 2.474E-2
1.770E-1
7.915E-1
 2 201
33 M2069 Genes selected in supervised analyses to discriminate cells expressing c-Myc [GeneID=4609] from control cells expressing GFP. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.156E-3 2.518E-2
1.802E-1
8.310E-1
 2 206
34 M5042 Up-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.223E-3 2.587E-2
1.851E-1
8.797E-1
 2 212
35 12970791-Table2b Human Lymphoma Qiu03 13genes GeneSigDB 1.296E-3 2.662E-2
1.905E-1
9.319E-1
 1 5
36 M5635 Genes down-regulated in LNCaP cells (prostate cancer) after knockdown of SAM68 [GeneID=10657] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.555E-3 3.064E-2
2.192E-1
1.000E0
 1 6
37 M12816 Genes down-regulated in MDA-MB-453 cells (class A ER(-) [GeneID=2099] breast cancer) after exposure to the androgen R1881 [PubChem=13766]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.577E-3 3.064E-2
2.192E-1
1.000E0
 2 241
38 17145885-SuppTable2 Human Lung Kobayashi06 320genes GeneSigDB 1.655E-3 3.132E-2
2.241E-1
1.000E0
 2 247
39 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.709E-3 3.150E-2
2.254E-1
1.000E0
 2 251
40 19373655-Table3 Mouse Lymphoma Saez09 16genes GeneSigDB 1.814E-3 3.181E-2
2.276E-1
1.000E0
 1 7
41 18661203-Table3 Mouse Uterine Kashiwazaki08 9genes GeneSigDB 1.814E-3 3.181E-2
2.276E-1
1.000E0
 1 7
42 M679 G1 to S phase regulators significantly changed in DanG cells (pancreatic cancer) treated with Ly294002 [PubChem=3973], a phosphoinositide 3-kinase (PI3K) inhibitor. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.073E-3 3.466E-2
2.480E-1
1.000E0
 1 8
43 16707422-tableS3c Human Prostate Hendriksen06 11genes GeneSigDB 2.073E-3 3.466E-2
2.480E-1
1.000E0
 1 8
44 M16807 Genes required for both proliferation and CTNNB1 [GeneID=1499] activity in DLD-1 cell (colon cancer with APC [GeneID=324] deletions). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.332E-3 3.811E-2
2.727E-1
1.000E0
 1 9
45 M11171 Genes up-regulated in fibroblasts expressing mutant forms of ERCC3 [GeneID=2071] after UV irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.574E-3 4.049E-2
2.898E-1
1.000E0
 2 309
46 M10504 Genes down-regulated in H1299 cells (non-small cell lung cancer, NSCLC) expressing the Y144F mutant form of FHIT [GeneID=2272]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.591E-3 4.049E-2
2.898E-1
1.000E0
 1 10
47 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.825E-3 4.322E-2
3.093E-1
1.000E0
 2 324
48 M854 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.894E-3 4.335E-2
3.102E-1
1.000E0
 2 328
49 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.017E-3 4.427E-2
3.168E-1
1.000E0
 2 335
50 18662380-S3-AURKA Human Breast Wirapati08 355genes AURKA Module GeneSigDB 3.178E-3 4.570E-2
3.270E-1
1.000E0
 2 344
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 258 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 83 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5464 MODULE 403 DNA damage response. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.226E-4 1.017E-2
5.089E-2
 1.017E-2 2 46

16: MicroRNA [Display Chart] 6 input genes in category / 299 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-223-3p:Functional MTI Functional MTI miRTarbase 2.723E-5 7.864E-3 4.938E-2 8.141E-3 2 98
2 hsa-miR-361-5p:Functional MTI Functional MTI miRTarbase 7.270E-5 7.864E-3 4.938E-2 2.174E-2 2 160
3 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 1.594E-4 7.864E-3 4.938E-2 4.765E-2 2 237
4 hsa-miR-296-3p:Functional MTI Functional MTI miRTarbase 1.888E-4 7.864E-3 4.938E-2
5.645E-2
 2 258
5 GTGCAAT,MIR-25:MSigDB GTGCAAT,MIR-25:MSigDB MSigDB 2.367E-4 7.864E-3 4.938E-2
7.078E-2
 2 289
6 GTGCAAT,MIR-367:MSigDB GTGCAAT,MIR-367:MSigDB MSigDB 2.367E-4 7.864E-3 4.938E-2
7.078E-2
 2 289
7 GTGCAAT,MIR-32:MSigDB GTGCAAT,MIR-32:MSigDB MSigDB 2.367E-4 7.864E-3 4.938E-2
7.078E-2
 2 289
8 GTGCAAT,MIR-92:MSigDB GTGCAAT,MIR-92:MSigDB MSigDB 2.367E-4 7.864E-3 4.938E-2
7.078E-2
 2 289
9 GTGCAAT,MIR-363:MSigDB GTGCAAT,MIR-363:MSigDB MSigDB 2.367E-4 7.864E-3 4.938E-2
7.078E-2
 2 289
10 hsa-miR-101-3p:Functional MTI Functional MTI miRTarbase 4.364E-4 1.305E-2
8.194E-2
1.305E-1
 2 393
11 hsa-miR-103a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 5.788E-4 1.573E-2
9.879E-2
1.731E-1
 2 453
12 hsa-miR-182-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 3.491E-2
2.192E-1
9.920E-1
 1 40
13 hsa-miR-6800-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.401E-3 3.491E-2
2.192E-1
1.000E0
 1 41
14 ACAACCT,MIR-453:MSigDB ACAACCT,MIR-453:MSigDB MSigDB 3.401E-3 3.491E-2
2.192E-1
1.000E0
 1 41
15 hsa-miR-2909:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.566E-3 3.491E-2
2.192E-1
1.000E0
 1 43
16 hsa-miR-3158-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.815E-3 3.491E-2
2.192E-1
1.000E0
 1 46
17 hsa-miR-6802-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.897E-3 3.491E-2
2.192E-1
1.000E0
 1 47
18 hsa-miR-5591-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.491E-2
2.192E-1
1.000E0
 1 49
19 hsa-miR-660-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 3.491E-2
2.192E-1
1.000E0
 1 50
20 hsa-miR-638:Functional MTI Functional MTI miRTarbase 4.394E-3 3.491E-2
2.192E-1
1.000E0
 1 53
21 hsa-miR-1295:mirSVR highEffct hsa-miR-1295:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.477E-3 3.491E-2
2.192E-1
1.000E0
 1 54
22 hsa-miR-1302:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.725E-3 3.491E-2
2.192E-1
1.000E0
 1 57
23 hsa-miR-500b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 3.491E-2
2.192E-1
1.000E0
 1 58
24 hsa-miR-4772-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 3.491E-2
2.192E-1
1.000E0
 1 58
25 TATCTGG,MIR-488:MSigDB TATCTGG,MIR-488:MSigDB MSigDB 4.973E-3 3.491E-2
2.192E-1
1.000E0
 1 60
26 hsa-miR-7976:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 3.491E-2
2.192E-1
1.000E0
 1 60
27 hsa-miR-6779-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 3.491E-2
2.192E-1
1.000E0
 1 60
28 hsa-miR-4298:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 3.491E-2
2.192E-1
1.000E0
 1 61
29 hsa-miR-4639-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.491E-2
2.192E-1
1.000E0
 1 63
30 hsa-miR-362-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.491E-2
2.192E-1
1.000E0
 1 63
31 hsa-miR-4705:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.491E-2
2.192E-1
1.000E0
 1 64
32 hsa-miR-885-5p:Functional MTI Functional MTI miRTarbase 5.304E-3 3.491E-2
2.192E-1
1.000E0
 1 64
33 GTGGTGA,MIR-197:MSigDB GTGGTGA,MIR-197:MSigDB MSigDB 5.469E-3 3.491E-2
2.192E-1
1.000E0
 1 66
34 hsa-miR-5088-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.469E-3 3.491E-2
2.192E-1
1.000E0
 1 66
35 hsa-miR-155-3p:Functional MTI Functional MTI miRTarbase 5.635E-3 3.491E-2
2.192E-1
1.000E0
 1 68
36 hsa-miR-548ba:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.491E-2
2.192E-1
1.000E0
 1 70
37 AAGGGAT,MIR-188:MSigDB AAGGGAT,MIR-188:MSigDB MSigDB 5.883E-3 3.491E-2
2.192E-1
1.000E0
 1 71
38 hsa-miR-892b:Functional MTI Functional MTI miRTarbase 5.883E-3 3.491E-2
2.192E-1
1.000E0
 1 71
39 hsa-miR-548ai:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.883E-3 3.491E-2
2.192E-1
1.000E0
 1 71
40 hsa-miR-570-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.491E-2
2.192E-1
1.000E0
 1 72
41 hsa-miR-411-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.491E-2
2.192E-1
1.000E0
 1 73
42 hsa-miR-548ag:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.491E-2
2.192E-1
1.000E0
 1 73
43 hsa-miR-3189-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.491E-2
2.192E-1
1.000E0
 1 73
44 hsa-miR-6856-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 3.491E-2
2.192E-1
1.000E0
 1 77
45 hsa-miR-380-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 3.491E-2
2.192E-1
1.000E0
 1 77
46 hsa-miR-6757-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.626E-3 3.491E-2
2.192E-1
1.000E0
 1 80
47 hsa-miR-345-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.709E-3 3.491E-2
2.192E-1
1.000E0
 1 81
48 hsa-miR-4446-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.491E-2
2.192E-1
1.000E0
 1 84
49 hsa-miR-379-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.491E-2
2.192E-1
1.000E0
 1 84
50 hsa-miR-450b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.122E-3 3.491E-2
2.192E-1
1.000E0
 1 86
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 3342 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000002607 AC1L1E22 Stitch 3.787E-7 1.266E-3 1.100E-2 1.266E-3 3 62
2 6052 DN Ethotoin [86-35-1]; Down 200; 19.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.203E-5 4.645E-3 4.037E-2 4.019E-2 3 195
3 5241 UP haloperidol; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.203E-5 4.645E-3 4.037E-2 4.019E-2 3 195
4 7400 UP Sulfadimethoxine [122-11-2]; Up 200; 12.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.221E-5 4.645E-3 4.037E-2 4.081E-2 3 196
5 1709 UP Adiphenine hydrochloride [50-42-0]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.240E-5 4.645E-3 4.037E-2 4.144E-2 3 197
6 6372 DN 3-nitropropionic acid; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.240E-5 4.645E-3 4.037E-2 4.144E-2 3 197
7 6261 UP Cefuroxime sodium salt [56238-63-2]; Up 200; 9uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.259E-5 4.645E-3 4.037E-2 4.207E-2 3 198
8 5400 UP S(+)-Terguride [37686-84-3]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.297E-5 4.645E-3 4.037E-2 4.336E-2 3 200
9 CID000137550 Anilino Stitch 2.327E-5 4.645E-3 4.037E-2
7.778E-2
 2 29
10 CID005494449 VX-680 Stitch 2.665E-5 4.645E-3 4.037E-2
8.906E-2
 2 31
11 ctd:D000880 Anthraquinones CTD 2.842E-5 4.645E-3 4.037E-2
9.499E-2
 2 32
12 ctd:C082164 4-methoxycinnamate methyl ester CTD 3.025E-5 4.645E-3 4.037E-2
1.011E-1
 2 33
13 CID000092180 isopentenyladenine Stitch 4.466E-5 4.645E-3 4.037E-2
1.492E-1
 2 40
14 CID000073431 secalonic acid D Stitch 1.115E-4 4.645E-3 4.037E-2
3.727E-1
 2 63
15 CID005327193 I-Br Stitch 1.300E-4 4.645E-3 4.037E-2
4.344E-1
 2 68
16 CID000061668 boronic acid Stitch 1.892E-4 4.645E-3 4.037E-2
6.323E-1
 2 82
17 CID004627201 AC1NDK7X Stitch 2.130E-4 4.645E-3 4.037E-2
7.119E-1
 2 87
18 CID000189906 butocrolol Stitch 2.594E-4 4.645E-3 4.037E-2
8.668E-1
 2 96
19 DB07538 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
20 DB08140 5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
21 DB06944 N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-(2-NAPHTHYL)ACETAMIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
22 DB08534 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
23 DB01888 4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
24 DB07504 (2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
25 DB03307 4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
26 CID009991833 2r3h Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
27 CID009926933 LZ-3 Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
28 CID006539554 AC1O6ZTG Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
29 DB08532 6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
30 DB07751 (2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
31 CID000448994 3 FP Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
32 DB08694 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
33 DB08441 6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
34 DB08241 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
35 CID006539299 AC1O6ZFA Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
36 DB04407 4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
37 DB06948 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
38 DB08539 3-cyclopropyl-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
39 DB08537 3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
40 DB04006 [2-Amino-6-(2,6-Difluoro-Benzoyl)-Imidazo[1,2-a]Pyridin-3-Yl]-Phenyl-Methanone Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
41 DB02538 N-[4-(2-Methylimidazo[1,2-a]Pyridin-3-Yl)-2-Pyrimidinyl]Acetamide Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
42 DB08247 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
43 CID004301225 AC1Q6GRE Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
44 DB07534 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
45 DB07761 (2R)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
46 DB07687 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
47 DB07618 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3 CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
48 DB08178 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
49 DB02197 4-[(4-Imidazo[1,2-a]Pyridin-3-Ylpyrimidin-2-Yl)Amino]Benzenesulfonamide Drug Bank 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
50 CID000161778 Vr 6 Stitch 2.627E-4 4.645E-3 4.037E-2
8.779E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 254 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0079748 Precursor cell lymphoblastic lymphoma DisGeNET BeFree 2.209E-4 1.703E-2
1.042E-1
5.611E-2
 2 63
2 C0205748 Dysplastic Nevus DisGeNET Curated 2.968E-4 1.703E-2
1.042E-1
7.538E-2
 2 73
3 cv:CN224990 Microcephaly and chorioretinopathy, autosomal recessive, 2 Clinical Variations 3.703E-4 1.703E-2
1.042E-1
9.405E-2
 1 1
4 C1274320 Recurrent herpes simplex infection of eye DisGeNET BeFree 3.703E-4 1.703E-2
1.042E-1
9.405E-2
 1 1
5 C0206701 Cystadenocarcinoma, Serous DisGeNET BeFree 3.836E-4 1.703E-2
1.042E-1
9.744E-2
 2 83
6 C0205698 Undifferentiated carcinoma DisGeNET BeFree 4.023E-4 1.703E-2
1.042E-1
1.022E-1
 2 85
7 C1412004 Tumor of the Pineal Region DisGeNET BeFree 7.404E-4 2.687E-2
1.643E-1
1.881E-1
 1 2
8 C0021841 Intestinal Neoplasms DisGeNET Curated 1.347E-3 3.746E-2
2.292E-1
3.420E-1
 2 156
9 C0919532 Genomic Instability DisGeNET Curated 1.480E-3 3.746E-2
2.292E-1
3.760E-1
 1 4
10 C0026010 Microphthalmos DisGeNET Curated 1.671E-3 3.746E-2
2.292E-1
4.245E-1
 2 174
11 C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 1.907E-3 3.746E-2
2.292E-1
4.843E-1
 2 186
12 C0023448 Lymphoid leukemia DisGeNET Curated 2.093E-3 3.746E-2
2.292E-1
5.317E-1
 2 195
13 C0334551 Myxoid chondrosarcoma DisGeNET BeFree 2.589E-3 3.746E-2
2.292E-1
6.577E-1
 1 7
14 C1841984 GLOMUVENOUS MALFORMATIONS DisGeNET Curated 2.589E-3 3.746E-2
2.292E-1
6.577E-1
 1 7
15 C4013426 Bronchial carcinoid DisGeNET BeFree 2.589E-3 3.746E-2
2.292E-1
6.577E-1
 1 7
16 C0278505 Non-small cell lung cancer stage II DisGeNET BeFree 2.589E-3 3.746E-2
2.292E-1
6.577E-1
 1 7
17 C0015398 Eye Diseases, Hereditary DisGeNET Curated 2.589E-3 3.746E-2
2.292E-1
6.577E-1
 1 7
18 C0220633 Uveal melanoma DisGeNET Curated 2.655E-3 3.746E-2
2.292E-1
6.744E-1
 2 220
19 C0023364 Leptospirosis DisGeNET BeFree 2.959E-3 3.758E-2
2.298E-1
7.515E-1
 1 8
20 C0019357 Keratitis, Herpetic DisGeNET BeFree 2.959E-3 3.758E-2
2.298E-1
7.515E-1
 1 8
21 C1849364 Absent earlobe DisGeNET Curated 3.328E-3 3.843E-2
2.350E-1
8.454E-1
 1 9
22 20081125:Hakonarson Type 1 diabetes GWAS 3.328E-3 3.843E-2
2.350E-1
8.454E-1
 1 9
23 C0019269 Hermaphroditism DisGeNET BeFree 3.697E-3 4.083E-2
2.498E-1
9.391E-1
 1 10
24 C3898222 Mucosal Melanoma DisGeNET BeFree 4.067E-3 4.304E-2
2.632E-1
1.000E0
 1 11
25 C1857230 DISORGANIZATION, MOUSE, HOMOLOG OF DisGeNET BeFree 4.436E-3 4.333E-2
2.650E-1
1.000E0
 1 12
26 C0015403 Eye Infections DisGeNET BeFree 4.436E-3 4.333E-2
2.650E-1
1.000E0
 1 12
27 C0036330 Schistosomiasis mansoni DisGeNET Curated 4.804E-3 4.363E-2
2.669E-1
1.000E0
 1 13
28 C0018922 hemangiopericytoma DisGeNET Curated 5.173E-3 4.363E-2
2.669E-1
1.000E0
 1 14
29 C0031941 Pineal Gland Neoplasm DisGeNET Curated 5.542E-3 4.363E-2
2.669E-1
1.000E0
 1 15
30 C0206368 Exfoliation Syndrome DisGeNET Curated 5.542E-3 4.363E-2
2.669E-1
1.000E0
 1 15
31 C4012968 Mild global developmental delay DisGeNET Curated 5.542E-3 4.363E-2
2.669E-1
1.000E0
 1 15
32 C2229182 Psychomotor retardation, mild DisGeNET Curated 5.542E-3 4.363E-2
2.669E-1
1.000E0
 1 15
33 C0278701 Gastric Adenocarcinoma DisGeNET BeFree 5.668E-3 4.363E-2
2.669E-1
1.000E0
 2 324
34 C0342573 PITUITARY DWARFISM I DisGeNET Curated 5.910E-3 4.415E-2
2.701E-1
1.000E0
 1 16
35 C0848332 Spots on skin DisGeNET BeFree 6.085E-3 4.416E-2
2.701E-1
1.000E0
 2 336
36 C0521158 Recurrent tumor DisGeNET BeFree 6.478E-3 4.429E-2
2.709E-1
1.000E0
 2 347
37 C1857656 Precociously senile appearance DisGeNET Curated 6.647E-3 4.429E-2
2.709E-1
1.000E0
 1 18
38 C2749675 Cortical gyral simplification DisGeNET Curated 7.015E-3 4.429E-2
2.709E-1
1.000E0
 1 19
39 C1322286 Thymoma, type C DisGeNET BeFree 7.015E-3 4.429E-2
2.709E-1
1.000E0
 1 19
40 C0740457 Malignant neoplasm of kidney DisGeNET BeFree 7.611E-3 4.429E-2
2.709E-1
1.000E0
 2 377
41 C0346300 Pituitary carcinoma DisGeNET BeFree 7.751E-3 4.429E-2
2.709E-1
1.000E0
 1 21
42 C2931038 Pancreatic carcinoma, familial DisGeNET Curated 7.751E-3 4.429E-2
2.709E-1
1.000E0
 1 21
43 C4024202 Reduced number of teeth DisGeNET Curated 7.751E-3 4.429E-2
2.709E-1
1.000E0
 1 21
44 C4083050 Agenesis of teeth DisGeNET Curated 7.751E-3 4.429E-2
2.709E-1
1.000E0
 1 21
45 C0853879 Invasive carcinoma of breast DisGeNET BeFree 7.927E-3 4.429E-2
2.709E-1
1.000E0
 2 385
46 C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 8.168E-3 4.429E-2
2.709E-1
1.000E0
 2 391
47 C0279592 T-cell adult acute lymphoblastic leukemia DisGeNET BeFree 8.487E-3 4.429E-2
2.709E-1
1.000E0
 1 23
48 C1865037 Cone-shaped epiphyses DisGeNET Curated 8.855E-3 4.429E-2
2.709E-1
1.000E0
 1 24
49 C1840069 Sandal gap DisGeNET Curated 8.855E-3 4.429E-2
2.709E-1
1.000E0
 1 24
50 C0267963 Exocrine pancreatic insufficiency DisGeNET Curated 9.222E-3 4.429E-2
2.709E-1
1.000E0
 1 25
Show 45 more annotations