|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
14527413
|
Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.
|
Pubmed
|
1.953E-13
|
1.825E-10
|
1.353E-9
|
1.825E-10
|
4
|
12
|
2
|
12417715
|
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
|
Pubmed
|
1.319E-10
|
6.160E-8
|
4.569E-7
|
1.232E-7
|
3
|
7
|
3
|
17803942
|
Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm.
|
Pubmed
|
8.637E-8
|
2.017E-5
|
1.496E-4
|
8.067E-5
|
2
|
3
|
4
|
22890540
|
New azaphilones and chlorinated phenolic glycosides from Chaetomium elatum with caspase-3 inhibitory activity.
|
Pubmed
|
8.637E-8
|
2.017E-5
|
1.496E-4
|
8.067E-5
|
2
|
3
|
5
|
19503078
|
A UPF3-mediated regulatory switch that maintains RNA surveillance.
|
Pubmed
|
1.727E-7
|
2.017E-5
|
1.496E-4
|
1.613E-4
|
2
|
4
|
6
|
11113196
|
Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).
|
Pubmed
|
1.727E-7
|
2.017E-5
|
1.496E-4
|
1.613E-4
|
2
|
4
|
7
|
21541368
|
A yeast model of FUS/TLS-dependent cytotoxicity.
|
Pubmed
|
1.727E-7
|
2.017E-5
|
1.496E-4
|
1.613E-4
|
2
|
4
|
8
|
11544179
|
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
|
Pubmed
|
1.727E-7
|
2.017E-5
|
1.496E-4
|
1.613E-4
|
2
|
4
|
9
|
15231747
|
A protein interaction framework for human mRNA degradation.
|
Pubmed
|
2.294E-7
|
2.381E-5
|
1.766E-4
|
2.143E-4
|
4
|
347
|
10
|
11163187
|
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
|
Pubmed
|
2.879E-7
|
2.444E-5
|
1.813E-4
|
2.689E-4
|
2
|
5
|
11
|
12723973
|
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells.
|
Pubmed
|
2.879E-7
|
2.444E-5
|
1.813E-4
|
2.689E-4
|
2
|
5
|
12
|
12554878
|
Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.
|
Pubmed
|
4.318E-7
|
2.880E-5
|
2.136E-4
|
4.033E-4
|
2
|
6
|
13
|
23821644
|
The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth.
|
Pubmed
|
4.318E-7
|
2.880E-5
|
2.136E-4
|
4.033E-4
|
2
|
6
|
14
|
15324659
|
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
|
Pubmed
|
4.318E-7
|
2.880E-5
|
2.136E-4
|
4.033E-4
|
2
|
6
|
15
|
26950371
|
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
|
Pubmed
|
6.044E-7
|
3.321E-5
|
2.463E-4
|
5.645E-4
|
2
|
7
|
16
|
14636577
|
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
|
Pubmed
|
6.044E-7
|
3.321E-5
|
2.463E-4
|
5.645E-4
|
2
|
7
|
17
|
17916692
|
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
|
Pubmed
|
6.044E-7
|
3.321E-5
|
2.463E-4
|
5.645E-4
|
2
|
7
|
18
|
16601204
|
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
|
Pubmed
|
8.058E-7
|
4.181E-5
|
3.101E-4
|
7.526E-4
|
2
|
8
|
19
|
21876179
|
Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.
|
Pubmed
|
1.036E-6
|
4.838E-5
|
3.588E-4
|
9.676E-4
|
2
|
9
|
20
|
16364915
|
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.
|
Pubmed
|
1.036E-6
|
4.838E-5
|
3.588E-4
|
9.676E-4
|
2
|
9
|
21
|
11546874
|
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
|
Pubmed
|
1.295E-6
|
5.759E-5
|
4.271E-4
|
1.209E-3
|
2
|
10
|
22
|
21145460
|
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.
|
Pubmed
|
1.899E-6
|
8.061E-5
|
5.979E-4
|
1.773E-3
|
2
|
12
|
23
|
16452507
|
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
|
Pubmed
|
2.617E-6
|
1.063E-4
|
7.884E-4
|
2.445E-3
|
2
|
14
|
24
|
27926873
|
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.
|
Pubmed
|
9.287E-6
|
3.614E-4
|
2.681E-3
|
8.674E-3
|
3
|
248
|
25
|
25036637
|
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
|
Pubmed
|
2.103E-5
|
7.855E-4
|
5.826E-3
|
1.964E-2
|
3
|
326
|
26
|
23444366
|
14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.
|
Pubmed
|
2.470E-5
|
8.875E-4
|
6.583E-3
|
2.307E-2
|
2
|
42
|
27
|
14676191
|
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
|
Pubmed
|
6.716E-5
|
9.057E-4
|
6.718E-3
|
6.272E-2
|
2
|
69
|
28
|
17979178
|
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
|
Pubmed
|
1.069E-4
|
9.057E-4
|
6.718E-3
|
9.986E-2
|
2
|
87
|
29
|
26253027
|
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
30
|
17785461
|
A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
31
|
18694759
|
Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
32
|
29912646
|
MicroRNA-141-3p/200a-3p target and may be involved in post-transcriptional repression of RNA decapping enzyme Dcp2 during renal development.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
33
|
21598387
|
Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
34
|
19327373
|
Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
35
|
24174471
|
PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
36
|
12923261
|
Functional characterization of the mammalian mRNA decapping enzyme hDcp2.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
37
|
12896901
|
Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
38
|
7607695
|
Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
39
|
11742007
|
Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavage.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
40
|
15240115
|
Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in early stage of type I diabetes mellitus through activation of JNK.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
41
|
20945390
|
Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
42
|
16281054
|
Structural insight into poly(A) binding and catalytic mechanism of human PARN.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
43
|
26482878
|
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
44
|
11884129
|
An SR-protein induced by HSVI binding to cells functioning as a splicing inhibitor of viral pre-mRNA.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
45
|
18628308
|
aPKC enables development of zonula adherens by antagonizing centripetal contraction of the circumferential actomyosin cables.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
46
|
20445233
|
Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
47
|
16125198
|
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
48
|
19704008
|
Human UPF1 participates in small RNA-induced mRNA downregulation.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
49
|
12815264
|
Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|
50
|
22817733
|
UPF1 involvement in nuclear functions.
|
Pubmed
|
1.833E-4
|
9.057E-4
|
6.718E-3
|
1.712E-1
|
1
|
1
|