Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc209_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 58 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070064 proline-rich region binding 1.633E-5 4.735E-4 2.200E-3 9.470E-4 2 20
2 GO:0031690 adrenergic receptor binding 1.633E-5 4.735E-4 2.200E-3 9.470E-4 2 20
3 GO:0050816 phosphothreonine residue binding 9.643E-4 1.119E-2
5.197E-2
5.593E-2
 1 3
4 GO:0031697 beta-1 adrenergic receptor binding 9.643E-4 1.119E-2
5.197E-2
5.593E-2
 1 3
5 GO:0070699 type II activin receptor binding 9.643E-4 1.119E-2
5.197E-2
5.593E-2
 1 3
6 GO:0050815 phosphoserine residue binding 1.607E-3 1.242E-2
5.773E-2
9.319E-2
 1 5
7 GO:0019871 sodium channel inhibitor activity 1.928E-3 1.242E-2
5.773E-2
1.118E-1
 1 6
8 GO:0046975 histone methyltransferase activity (H3-K36 specific) 1.928E-3 1.242E-2
5.773E-2
1.118E-1
 1 6
9 GO:0031698 beta-2 adrenergic receptor binding 1.928E-3 1.242E-2
5.773E-2
1.118E-1
 1 6
10 GO:0070697 activin receptor binding 2.570E-3 1.490E-2
6.925E-2
1.490E-1
 1 8
11 GO:0001664 G protein-coupled receptor binding 3.144E-3 1.658E-2
7.701E-2
1.823E-1
 2 276
12 GO:0017166 vinculin binding 3.853E-3 1.862E-2
8.649E-2
2.235E-1
 1 12
13 GO:0008432 JUN kinase binding 4.173E-3 1.862E-2
8.649E-2
2.420E-1
 1 13
14 GO:0048156 tau protein binding 4.494E-3 1.862E-2
8.649E-2
2.606E-1
 1 14
15 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6.094E-3 2.325E-2
1.080E-1
3.535E-1
 1 19
16 GO:0033612 receptor serine/threonine kinase binding 6.414E-3 2.325E-2
1.080E-1
3.720E-1
 1 20
17 GO:0030159 receptor signaling complex scaffold activity 8.332E-3 2.843E-2
1.321E-1
4.832E-1
 1 26
18 GO:0045309 protein phosphorylated amino acid binding 8.970E-3 2.890E-2
1.343E-1
5.203E-1
 1 28
19 GO:0035035 histone acetyltransferase binding 9.608E-3 2.933E-2
1.363E-1
5.573E-1
 1 30
20 GO:0017080 sodium channel regulator activity 1.088E-2 3.121E-2
1.450E-1
6.313E-1
 1 34
21 GO:0001540 amyloid-beta binding 1.152E-2 3.121E-2
1.450E-1
6.682E-1
 1 36
22 GO:0070063 RNA polymerase binding 1.184E-2 3.121E-2
1.450E-1
6.867E-1
 1 37
23 GO:0008200 ion channel inhibitor activity 1.248E-2 3.146E-2
1.462E-1
7.236E-1
 1 39
24 GO:0016248 channel inhibitor activity 1.311E-2 3.169E-2
1.472E-1
7.605E-1
 1 41
25 GO:0018024 histone-lysine N-methyltransferase activity 1.470E-2 3.411E-2
1.585E-1
8.527E-1
 1 46
26 GO:0042054 histone methyltransferase activity 1.882E-2 4.199E-2
1.951E-1
1.000E0
 1 59
27 GO:0046332 SMAD binding 2.451E-2 4.964E-2
2.307E-1
1.000E0
 1 77
28 GO:0051219 phosphoprotein binding 2.482E-2 4.964E-2
2.307E-1
1.000E0
 1 78
29 GO:0032947 protein-containing complex scaffold activity 2.482E-2 4.964E-2
2.307E-1
1.000E0
 1 78
Show 24 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 336 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050808 synapse organization 5.097E-5 8.289E-3
5.302E-2
 1.713E-2 3 258
2 GO:2000649 regulation of sodium ion transmembrane transporter activity 7.766E-5 8.289E-3
5.302E-2
 2.609E-2 2 43
3 GO:0007528 neuromuscular junction development 1.052E-4 8.289E-3
5.302E-2
 3.536E-2 2 50
4 GO:1902305 regulation of sodium ion transmembrane transport 1.183E-4 8.289E-3
5.302E-2
 3.976E-2 2 53
5 GO:0050760 negative regulation of thymidylate synthase biosynthetic process 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
6 GO:0019089 transmission of virus 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
7 GO:0051821 dissemination or transmission of organism from other organism involved in symbiotic interaction 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
8 GO:0044007 dissemination or transmission of symbiont from host 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
9 GO:0044111 development involved in symbiotic interaction 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
10 GO:0007527 adult somatic muscle development 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
11 GO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage 3.222E-4 8.289E-3
5.302E-2
1.083E-1
 1 1
12 GO:0002028 regulation of sodium ion transport 3.271E-4 8.289E-3
5.302E-2
1.099E-1
 2 88
13 GO:0031623 receptor internalization 3.346E-4 8.289E-3
5.302E-2
1.124E-1
 2 89
14 GO:0010975 regulation of neuron projection development 3.454E-4 8.289E-3
5.302E-2
1.161E-1
 3 492
15 GO:0050757 thymidylate synthase biosynthetic process 6.443E-4 1.183E-2
7.569E-2
2.165E-1
 1 2
16 GO:0097198 histone H3-K36 trimethylation 6.443E-4 1.183E-2
7.569E-2
2.165E-1
 1 2
17 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage 6.443E-4 1.183E-2
7.569E-2
2.165E-1
 1 2
18 GO:0050758 regulation of thymidylate synthase biosynthetic process 6.443E-4 1.183E-2
7.569E-2
2.165E-1
 1 2
19 GO:0050807 regulation of synapse organization 6.692E-4 1.183E-2
7.569E-2
2.249E-1
 2 126
20 GO:0035725 sodium ion transmembrane transport 7.341E-4 1.233E-2
7.888E-2
2.467E-1
 2 132
21 GO:0097676 histone H3-K36 dimethylation 9.663E-4 1.546E-2
9.888E-2
3.247E-1
 1 3
22 GO:0043112 receptor metabolic process 1.143E-3 1.746E-2
1.117E-1
3.842E-1
 2 165
23 GO:0035441 cell migration involved in vasculogenesis 1.288E-3 1.803E-2
1.153E-1
4.328E-1
 1 4
24 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly 1.288E-3 1.803E-2
1.153E-1
4.328E-1
 1 4
25 GO:2000809 positive regulation of synaptic vesicle clustering 1.610E-3 2.081E-2
1.331E-1
5.410E-1
 1 5
26 GO:0007525 somatic muscle development 1.610E-3 2.081E-2
1.331E-1
5.410E-1
 1 5
27 GO:0032412 regulation of ion transmembrane transporter activity 1.690E-3 2.103E-2
1.345E-1
5.678E-1
 2 201
28 GO:0022898 regulation of transmembrane transporter activity 1.774E-3 2.110E-2
1.350E-1
5.960E-1
 2 206
29 GO:0050847 progesterone receptor signaling pathway 1.932E-3 2.110E-2
1.350E-1
6.491E-1
 1 6
30 GO:0006814 sodium ion transport 1.984E-3 2.110E-2
1.350E-1
6.665E-1
 2 218
31 GO:0032409 regulation of transporter activity 2.038E-3 2.110E-2
1.350E-1
6.847E-1
 2 221
32 GO:1901631 positive regulation of presynaptic membrane organization 2.253E-3 2.110E-2
1.350E-1
7.572E-1
 1 7
33 GO:0003402 planar cell polarity pathway involved in axis elongation 2.253E-3 2.110E-2
1.350E-1
7.572E-1
 1 7
34 GO:2000807 regulation of synaptic vesicle clustering 2.253E-3 2.110E-2
1.350E-1
7.572E-1
 1 7
35 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway 2.253E-3 2.110E-2
1.350E-1
7.572E-1
 1 7
36 GO:0046822 regulation of nucleocytoplasmic transport 2.320E-3 2.110E-2
1.350E-1
7.794E-1
 2 236
37 GO:1904062 regulation of cation transmembrane transport 2.358E-3 2.110E-2
1.350E-1
7.924E-1
 2 238
38 GO:0007050 cell cycle arrest 2.537E-3 2.110E-2
1.350E-1
8.525E-1
 2 247
39 GO:0097104 postsynaptic membrane assembly 2.575E-3 2.110E-2
1.350E-1
8.652E-1
 1 8
40 GO:0010793 regulation of mRNA export from nucleus 2.575E-3 2.110E-2
1.350E-1
8.652E-1
 1 8
41 GO:2000197 regulation of ribonucleoprotein complex localization 2.575E-3 2.110E-2
1.350E-1
8.652E-1
 1 8
42 GO:0097091 synaptic vesicle clustering 2.897E-3 2.163E-2
1.383E-1
9.732E-1
 1 9
43 GO:0014894 response to denervation involved in regulation of muscle adaptation 2.897E-3 2.163E-2
1.383E-1
9.732E-1
 1 9
44 GO:0038180 nerve growth factor signaling pathway 2.897E-3 2.163E-2
1.383E-1
9.732E-1
 1 9
45 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation 2.897E-3 2.163E-2
1.383E-1
9.732E-1
 1 9
46 GO:0050803 regulation of synapse structure or activity 3.067E-3 2.207E-2
1.411E-1
1.000E0
 2 272
47 GO:0010452 histone H3-K36 methylation 3.218E-3 2.207E-2
1.411E-1
1.000E0
 1 10
48 GO:1901629 regulation of presynaptic membrane organization 3.218E-3 2.207E-2
1.411E-1
1.000E0
 1 10
49 GO:0014870 response to muscle inactivity 3.218E-3 2.207E-2
1.411E-1
1.000E0
 1 10
50 GO:0010976 positive regulation of neuron projection development 3.385E-3 2.244E-2
1.435E-1
1.000E0
 2 286
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 50 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098858 actin-based cell projection 2.359E-5 1.180E-3 5.308E-3 1.180E-3 3 204
2 GO:0098794 postsynapse 2.463E-4 6.157E-3 2.770E-2 1.231E-2 3 449
3 GO:0030175 filopodium 4.194E-4 6.991E-3 3.145E-2 2.097E-2 2 102
4 GO:1990761 growth cone lamellipodium 9.441E-4 9.441E-3 4.248E-2 4.720E-2 1 3
5 GO:1990812 growth cone filopodium 9.441E-4 9.441E-3 4.248E-2 4.720E-2 1 3
6 GO:0030426 growth cone 1.326E-3 9.995E-3 4.497E-2
6.631E-2
 2 182
7 GO:0030427 site of polarized growth 1.399E-3 9.995E-3 4.497E-2
6.997E-2
 2 187
8 GO:0045211 postsynaptic membrane 2.017E-3 1.258E-2
5.660E-2
1.008E-1
 2 225
9 GO:0036056 filtration diaphragm 2.516E-3 1.258E-2
5.660E-2
1.258E-1
 1 8
10 GO:0036057 slit diaphragm 2.516E-3 1.258E-2
5.660E-2
1.258E-1
 1 8
11 GO:0005938 cell cortex 2.805E-3 1.275E-2
5.736E-2
1.402E-1
 2 266
12 GO:0097060 synaptic membrane 3.505E-3 1.451E-2
6.527E-2
1.753E-1
 2 298
13 GO:0070938 contractile ring 3.772E-3 1.451E-2
6.527E-2
1.886E-1
 1 12
14 GO:0099568 cytoplasmic region 4.155E-3 1.484E-2
6.676E-2
2.077E-1
 2 325
15 GO:0031252 cell leading edge 5.902E-3 1.755E-2
7.896E-2
2.951E-1
 2 389
16 GO:0016327 apicolateral plasma membrane 5.967E-3 1.755E-2
7.896E-2
2.983E-1
 1 19
17 GO:0031527 filopodium membrane 5.967E-3 1.755E-2
7.896E-2
2.983E-1
 1 19
18 GO:0090665 glycoprotein complex 6.906E-3 1.817E-2
8.177E-2
3.453E-1
 1 22
19 GO:0016010 dystrophin-associated glycoprotein complex 6.906E-3 1.817E-2
8.177E-2
3.453E-1
 1 22
20 GO:0031594 neuromuscular junction 1.874E-2 4.685E-2
2.108E-1
9.371E-1
 1 60
Show 15 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 180 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 190 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 73 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00397 WW Pfam 4.779E-13 1.182E-11 5.761E-11 3.488E-11 5 47
2 SM00456 WW SMART 5.334E-13 1.182E-11 5.761E-11 3.894E-11 5 48
3 PS50020 WW DOMAIN 2 PROSITE 7.316E-13 1.182E-11 5.761E-11 5.341E-11 5 51
4 PS01159 WW DOMAIN 1 PROSITE 7.316E-13 1.182E-11 5.761E-11 5.341E-11 5 51
5 IPR001202 WW dom InterPro 8.094E-13 1.182E-11 5.761E-11 5.909E-11 5 52
6 IPR013257 SRI InterPro 3.203E-4 2.598E-3 1.266E-2 2.338E-2 1 1
7 IPR017993 Atrophin-1 InterPro 3.203E-4 2.598E-3 1.266E-2 2.338E-2 1 1
8 PF08236 SRI Pfam 3.203E-4 2.598E-3 1.266E-2 2.338E-2 1 1
9 IPR030036 MAGI2 InterPro 3.203E-4 2.598E-3 1.266E-2 2.338E-2 1 1
10 PF03154 Atrophin-1 Pfam 6.404E-4 3.896E-3 1.899E-2 4.675E-2 1 2
11 IPR016344 Dystrophin InterPro 6.404E-4 3.896E-3 1.899E-2 4.675E-2 1 2
12 IPR002951 Atrophin-like InterPro 6.404E-4 3.896E-3 1.899E-2 4.675E-2 1 2
13 IPR006560 AWS dom InterPro 1.600E-3 7.378E-3 3.596E-2
1.168E-1
 1 5
14 SM00570 AWS SMART 1.600E-3 7.378E-3 3.596E-2
1.168E-1
 1 5
15 PS51215 AWS PROSITE 1.600E-3 7.378E-3 3.596E-2
1.168E-1
 1 5
16 IPR015153 EF-hand dom typ1 InterPro 1.920E-3 7.378E-3 3.596E-2
1.402E-1
 1 6
17 PF09069 EF-hand 3 Pfam 1.920E-3 7.378E-3 3.596E-2
1.402E-1
 1 6
18 PF09068 EF-hand 2 Pfam 1.920E-3 7.378E-3 3.596E-2
1.402E-1
 1 6
19 IPR015154 EF-hand dom typ2 InterPro 1.920E-3 7.378E-3 3.596E-2
1.402E-1
 1 6
20 IPR009078 Ferritin-like SF InterPro 4.476E-3 1.463E-2
7.131E-2
3.267E-1
 1 14
21 IPR020590 Guanylate kinase CS InterPro 5.114E-3 1.463E-2
7.131E-2
3.733E-1
 1 16
22 PS50868 POST SET PROSITE 5.114E-3 1.463E-2
7.131E-2
3.733E-1
 1 16
23 IPR003616 Post-SET dom InterPro 5.433E-3 1.463E-2
7.131E-2
3.966E-1
 1 17
24 SM00508 PostSET SMART 5.433E-3 1.463E-2
7.131E-2
3.966E-1
 1 17
25 PS50135 ZF ZZ 2 PROSITE 5.752E-3 1.463E-2
7.131E-2
4.199E-1
 1 18
26 PS01357 ZF ZZ 1 PROSITE 5.752E-3 1.463E-2
7.131E-2
4.199E-1
 1 18
27 PF00569 ZZ Pfam 5.752E-3 1.463E-2
7.131E-2
4.199E-1
 1 18
28 SM00291 ZnF ZZ SMART 6.070E-3 1.463E-2
7.131E-2
4.431E-1
 1 19
29 IPR000433 Znf ZZ InterPro 6.070E-3 1.463E-2
7.131E-2
4.431E-1
 1 19
30 PS00020 ACTININ 2 PROSITE 7.344E-3 1.463E-2
7.131E-2
5.361E-1
 1 23
31 PS00856 GUANYLATE KINASE 1 PROSITE 7.344E-3 1.463E-2
7.131E-2
5.361E-1
 1 23
32 PS00019 ACTININ 1 PROSITE 7.344E-3 1.463E-2
7.131E-2
5.361E-1
 1 23
33 PF00435 Spectrin Pfam 7.344E-3 1.463E-2
7.131E-2
5.361E-1
 1 23
34 IPR001589 Actinin actin-bd CS InterPro 7.344E-3 1.463E-2
7.131E-2
5.361E-1
 1 23
35 PS50052 GUANYLATE KINASE 2 PROSITE 7.344E-3 1.463E-2
7.131E-2
5.361E-1
 1 23
36 IPR008145 GK/Ca channel bsu InterPro 8.299E-3 1.463E-2
7.131E-2
6.058E-1
 1 26
37 PF00625 Guanylate kin Pfam 8.299E-3 1.463E-2
7.131E-2
6.058E-1
 1 26
38 SM00072 GuKc SMART 8.299E-3 1.463E-2
7.131E-2
6.058E-1
 1 26
39 IPR008144 Guanylate kin-like dom InterPro 8.299E-3 1.463E-2
7.131E-2
6.058E-1
 1 26
40 SM00119 HECTc SMART 8.617E-3 1.463E-2
7.131E-2
6.290E-1
 1 27
41 PF00632 HECT Pfam 8.617E-3 1.463E-2
7.131E-2
6.290E-1
 1 27
42 IPR000569 HECT dom InterPro 8.617E-3 1.463E-2
7.131E-2
6.290E-1
 1 27
43 PS50237 HECT PROSITE 8.617E-3 1.463E-2
7.131E-2
6.290E-1
 1 27
44 PF00640 PID Pfam 8.935E-3 1.482E-2
7.226E-2
6.522E-1
 1 28
45 IPR002017 Spectrin repeat InterPro 9.253E-3 1.501E-2
7.317E-2
6.755E-1
 1 29
46 IPR018159 Spectrin/alpha-actinin InterPro 1.021E-2 1.552E-2
7.566E-2
7.450E-1
 1 32
47 SM00150 SPEC SMART 1.021E-2 1.552E-2
7.566E-2
7.450E-1
 1 32
48 PS01179 PID PROSITE 1.021E-2 1.552E-2
7.566E-2
7.450E-1
 1 32
49 SM00462 PTB SMART 1.274E-2 1.869E-2
9.113E-2
9.303E-1
 1 40
50 IPR006020 PTB/PI dom InterPro 1.306E-2 1.869E-2
9.113E-2
9.534E-1
 1 41
Show 45 more annotations

7: Pathway [Display Chart] 5 input genes in category / 29 annotations before applied cutoff / 12450 genes in category

No results to display

8: Pubmed [Display Chart] 6 input genes in category / 932 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21198641 SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. Pubmed 4.318E-7 2.012E-4 1.492E-3 4.024E-4 2 7
2 9647693 Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Pubmed 4.318E-7 2.012E-4 1.492E-3 4.024E-4 2 7
3 24907641 Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
4 20078934 [Distribution of genetic variation of neural precursor cell expressed developmentally down-regulated 4 gene in Kazak Chinese and its association with hypertension]. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
5 21749564 Differential clinical features in a pair of monozygotic twins with dentatorubropallidoluysian atrophy. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
6 18804462 Nedd4, a human ubiquitin ligase, affects actin cytoskeleton in yeast cells. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
7 25527121 NEDD4: The founding member of a family of ubiquitin-protein ligases. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
8 20944102 Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
9 12619170 Relationship between utrophin and regenerating muscle fibers in duchenne muscular dystrophy. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
10 16595608 Naturally occurring utrophin correlates with disease severity in Duchenne muscular dystrophy. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
11 20101691 Deletion of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
12 7738095 Interaction of chromosome-6-encoded dystrophin related protein with the extracellular matrix. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
13 26084711 Brief Report: SETD2 Mutation in a Child with Autism, Intellectual Disabilities and Epilepsy. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
14 23065515 The role of a newly identified SET domain-containing protein, SETD3, in oncogenesis. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
15 18565486 Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
16 26015394 Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
17 24931610 SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
18 11606623 Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
19 1426262 Utrophin, the autosomal homologue of dystrophin, is widely-expressed and membrane-associated in cultured cell lines. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
20 24496234 Associations between keloid severity and single-nucleotide polymorphisms: importance of rs8032158 as a biomarker of keloid severity. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
21 25653350 S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
22 10085113 Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
23 2541343 An autosomal transcript in skeletal muscle with homology to dystrophin. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
24 27577205 [Clinical and genetic characteristics of patients with dentatorubro-pallidoluysian atrophy]. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
25 11551978 Distinct regions in the 3' untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
26 18945675 Targeting artificial transcription factors to the utrophin A promoter: effects on dystrophic pathology and muscle function. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
27 27542250 Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
28 24509477 Identification of functional cooperative mutations of SETD2 in human acute leukemia. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
29 8649981 Molecular and functional analysis of the utrophin promoter. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
30 11095528 Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
31 18401706 A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
32 9405440 The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
33 14689444 Isoform-specific knockout of FE65 leads to impaired learning and memory. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
34 22992774 Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
35 8965642 DRPLA gene (atrophin-1) sequence and mRNA expression in human brain. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
36 16198105 A and B utrophin in human muscle and sarcolemmal A-utrophin associated with tumours. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
37 11065130 A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
38 19835589 Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
39 17692845 Heregulin-induced epigenetic regulation of the utrophin-A promoter. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
40 22849377 Localisation and role of activin receptor-interacting protein 1 in mouse brain. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
41 16407196 Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
42 11726694 The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic up-regulation in Duchenne muscular dystrophy. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
43 10652301 Utrophin transcription is activated by an intronic enhancer. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
44 22216264 Translational regulation of utrophin by miRNAs. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
45 7485154 Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
46 9738440 Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
47 16457992 Pathological pattern of Mdx mice diaphragm correlates with gradual expression of the short utrophin isoform Up71. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
48 26230628 Cis-Acting Sequence Elements and Upstream Open Reading Frame in Mouse Utrophin-A 5'-UTR Repress Cap-Dependent Translation. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
49 24706662 SETD2 mutations cooperate with chromosomal aberrations in leukemia. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
50 20501857 Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Pubmed 1.571E-4 6.685E-4 4.957E-3
1.464E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 586 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:IQSEC3 IQSEC3 interactions 2.678E-6 1.569E-3 1.091E-2 1.569E-3 2 8
2 int:MAGI2 MAGI2 interactions 1.814E-5 5.315E-3 3.695E-2 1.063E-2 2 20
3 int:CTNND2 CTNND2 interactions 3.604E-5 7.041E-3 4.894E-2 2.112E-2 2 28
4 int:PTEN PTEN interactions 9.557E-5 1.205E-2
8.374E-2
5.600E-2
 3 303
5 int:MGRN1 MGRN1 interactions 1.028E-4 1.205E-2
8.374E-2
6.023E-2
 2 47
6 int:ARRDC3 ARRDC3 interactions 1.260E-4 1.207E-2
8.392E-2
7.383E-2
 2 52
7 int:CASP1 CASP1 interactions 1.853E-4 1.207E-2
8.392E-2
1.086E-1
 2 63
8 int:SMAD3 SMAD3 interactions 1.914E-4 1.207E-2
8.392E-2
1.122E-1
 3 383
9 int:RAPGEF2 RAPGEF2 interactions 2.223E-4 1.207E-2
8.392E-2
1.303E-1
 2 69
10 int:DMD DMD interactions 2.288E-4 1.207E-2
8.392E-2
1.341E-1
 2 70
11 int:DVL1 DVL1 interactions 2.558E-4 1.207E-2
8.392E-2
1.499E-1
 2 74
12 int:DIAPH1 DIAPH1 interactions 2.627E-4 1.207E-2
8.392E-2
1.540E-1
 2 75
13 int:LRP2 LRP2 interactions 2.770E-4 1.207E-2
8.392E-2
1.623E-1
 2 77
14 int:CASP7 CASP7 interactions 2.915E-4 1.207E-2
8.392E-2
1.708E-1
 2 79
15 int:BAIAP2 BAIAP2 interactions 3.296E-4 1.207E-2
8.392E-2
1.932E-1
 2 84
16 int:SIAH2 SIAH2 interactions 3.296E-4 1.207E-2
8.392E-2
1.932E-1
 2 84
17 int:THOC1 THOC1 interactions 3.783E-4 1.219E-2
8.476E-2
2.217E-1
 2 90
18 int:SAV1 SAV1 interactions 3.868E-4 1.219E-2
8.476E-2
2.267E-1
 2 91
19 int:FAM189B FAM189B interactions 3.953E-4 1.219E-2
8.476E-2
2.317E-1
 2 92
20 int:ATN1 ATN1 interactions 5.146E-4 1.508E-2
1.048E-1
3.016E-1
 2 105
21 int:MARK2 MARK2 interactions 5.646E-4 1.576E-2
1.095E-1
3.309E-1
 2 110
22 int:RASGEF1A RASGEF1A interactions 6.778E-4 1.750E-2
1.217E-1
3.972E-1
 1 2
23 int:BECN1 BECN1 interactions 7.167E-4 1.750E-2
1.217E-1
4.200E-1
 2 124
24 int:PDCD6IP PDCD6IP interactions 7.167E-4 1.750E-2
1.217E-1
4.200E-1
 2 124
25 int:CPSF6 CPSF6 interactions 7.994E-4 1.874E-2
1.303E-1
4.685E-1
 2 131
26 int:MLANA MLANA interactions 1.016E-3 2.054E-2
1.428E-1
5.957E-1
 1 3
27 int:SLC22A8 SLC22A8 interactions 1.016E-3 2.054E-2
1.428E-1
5.957E-1
 1 3
28 int:MEGF11 MEGF11 interactions 1.016E-3 2.054E-2
1.428E-1
5.957E-1
 1 3
29 int:SLC5A7 SLC5A7 interactions 1.016E-3 2.054E-2
1.428E-1
5.957E-1
 1 3
30 int:THRAP3 THRAP3 interactions 1.204E-3 2.308E-2
1.604E-1
7.054E-1
 2 161
31 int:DSCAML1 DSCAML1 interactions 1.355E-3 2.308E-2
1.604E-1
7.941E-1
 1 4
32 int:SLC23A2 SLC23A2 interactions 1.355E-3 2.308E-2
1.604E-1
7.941E-1
 1 4
33 int:SRMS SRMS interactions 1.355E-3 2.308E-2
1.604E-1
7.941E-1
 1 4
34 int:GRK7 GRK7 interactions 1.355E-3 2.308E-2
1.604E-1
7.941E-1
 1 4
35 int:CASP3 CASP3 interactions 1.568E-3 2.308E-2
1.604E-1
9.189E-1
 2 184
36 int:TSHZ1 TSHZ1 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
37 int:PRRG1 PRRG1 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
38 int:PRRG3 PRRG3 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
39 int:DRP2 DRP2 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
40 int:SLIT1 SLIT1 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
41 int:TSHZ2 TSHZ2 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
42 int:ILDR1 ILDR1 interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
43 int:SSPO SSPO interactions 1.694E-3 2.308E-2
1.604E-1
9.925E-1
 1 5
44 int:ERMN ERMN interactions 2.032E-3 2.481E-2
1.725E-1
1.000E0
 1 6
45 int:RHBDL1 RHBDL1 interactions 2.032E-3 2.481E-2
1.725E-1
1.000E0
 1 6
46 int:ANXA9 ANXA9 interactions 2.032E-3 2.481E-2
1.725E-1
1.000E0
 1 6
47 int:PRRG2 PRRG2 interactions 2.032E-3 2.481E-2
1.725E-1
1.000E0
 1 6
48 int:STK31 STK31 interactions 2.032E-3 2.481E-2
1.725E-1
1.000E0
 1 6
49 int:LATS2 LATS2 interactions 2.094E-3 2.504E-2
1.740E-1
1.000E0
 2 213
50 int:ABL1 ABL1 interactions 2.353E-3 2.511E-2
1.745E-1
1.000E0
 2 226
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q24 6q24 1.154E-3 4.685E-3 1.070E-2 5.768E-3 1 8
2 7q21 7q21 1.874E-3 4.685E-3 1.070E-2 9.370E-3 1 13
3 11p15 11p15 6.762E-3 1.127E-2 2.573E-2 3.381E-2 1 47
4 12p13.31 12p13.31 1.192E-2 1.477E-2 3.373E-2
5.958E-2
 1 83
5 3p21.31 3p21.31 1.477E-2 1.477E-2 3.373E-2
7.386E-2
 1 103

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 67 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 91 Zinc fingers ZZ-type genenames.org 2.965E-3 7.461E-3 1.554E-2 1.186E-2 1 18
2 904 Calcium voltage-gated channel subunits|Membrane associated guanylate kinases genenames.org 4.281E-3 7.461E-3 1.554E-2 1.712E-2 1 26
3 487 Lysine methyltransferases|RNA binding motif containing genenames.org 5.596E-3 7.461E-3 1.554E-2 2.238E-2 1 34
4 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 2.486E-2 2.486E-2
5.178E-2
9.942E-2
 1 152

13: Coexpression [Display Chart] 6 input genes in category / 577 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18413728-Table2a Human Brain Molenaar08 69genes GeneSigDB 9.854E-5 3.548E-2
2.461E-1
5.686E-2
 2 60
2 M11763 Genes commonly up-regulated in SK-N-BE cells (neuroblastoma) after RNAi knockdown of CCND1 and CDK4 [GeneID=595;1019]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.230E-4 3.548E-2
2.461E-1
7.096E-2
 2 67
3 15486989-table2 Rat Prostate Reyes05 189genes GeneSigDB 4.013E-4 3.931E-2
2.727E-1
2.316E-1
 2 121
4 M15659 Cluster 5: early responding genes activated in ATM [GeneID=472] deficient but not in the wild type tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.914E-4 3.931E-2
2.727E-1
3.413E-1
 2 147
5 M8188 Genes down-regulated in double positive thymocytes: wildtype versus over-expressing HDAC7[GeneID=51564] fused with VP16. MSigDB C7: Immunologic Signatures (v6.0) 7.622E-4 3.931E-2
2.727E-1
4.398E-1
 2 167
6 M8239 Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells treated by digoxin [PubChem=2724385]: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.896E-4 3.931E-2
2.727E-1
4.556E-1
 2 170
7 M15327 Genes with basal expression distinguishing NCI-60 cell lines with poor survival after 2 Gy gamma irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.989E-4 3.931E-2
2.727E-1
4.609E-1
 2 171
8 M8186 Genes up-regulated in B lymphocytes after immunization with: monophosphoryl lipid A versus imiquimod [PubChem=13982876]. MSigDB C7: Immunologic Signatures (v6.0) 7.989E-4 3.931E-2
2.727E-1
4.609E-1
 2 171
9 M7836 Genes down-regulated in NK cells: fresh versus stimulated with IL2 [GeneID=3558], IL-12 and IL15 [GeneID=3600]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
10 M4673 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus CD8 T cells treated with leukocyte costimulatory blockade antibodies. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
11 M8805 Genes down-regulated in Foxp3-ires-GFP T reg (FOXP3+ [GeneID=50943]): B6 versus NOD background. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
12 M9608 Genes up-regulated in CD42 low [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
13 M9260 Genes down-regulated in CXCR5+ BCL6+ [GeneID=643;604] follicular helper T cells versus CXCR5+ BCL6- CD4+ [GeneID=643;604;920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
14 M6633 Genes up-regulated in bone marrow-derived macrophages with IL10 [GeneID=3486] and 180 min stimulation of: LPS versus IL10 [GeneID=3486] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
15 M9253 Genes down-regulated in dendritic cells: hydrogen peroxide [PubChem=784] versus diphenyleneiodonium (DPI) [PubChem=2733504]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
16 M8027 Genes down-regulated in macrophages (12h): rosiglitazone [PubChem=77999] and IL4 [GeneID=3565] versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.931E-2
2.727E-1
6.290E-1
 2 200
Show 11 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 439 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 6 input genes in category / 21 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 210 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1308:PITA hsa-miR-1308:PITA TOP PITA 3.127E-5 3.604E-3 2.136E-2 6.566E-3 2 105
2 hsa-miR-1973:mirSVR highEffct hsa-miR-1973:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.433E-5 3.604E-3 2.136E-2 7.208E-3 2 110
3 hsa-miR-219-2-3p:PITA hsa-miR-219-2-3p:PITA TOP PITA 1.025E-4 6.825E-3 4.045E-2 2.153E-2 2 190
4 hsa-miR-1237:PITA hsa-miR-1237:PITA TOP PITA 1.300E-4 6.825E-3 4.045E-2 2.730E-2 2 214
5 hsa-miR-3200:mirSVR highEffct hsa-miR-3200:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.298E-4 1.397E-2
8.279E-2
9.027E-2
 2 390
6 hsa-miR-638:mirSVR lowEffct hsa-miR-638:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.476E-4 1.397E-2
8.279E-2
9.399E-2
 2 398
7 hsa-miR-331-3p:Functional MTI Functional MTI miRTarbase 4.656E-4 1.397E-2
8.279E-2
9.778E-2
 2 406
8 hsa-miR-487b-3p:Functional MTI Functional MTI miRTarbase 1.660E-3 3.614E-2
2.142E-1
3.486E-1
 1 20
9 hsa-miR-887:PITA hsa-miR-887:PITA TOP PITA 1.992E-3 3.614E-2
2.142E-1
4.183E-1
 1 24
10 hsa-miR-6718-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.235E-3 3.614E-2
2.142E-1
6.793E-1
 1 39
11 hsa-miR-203b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.235E-3 3.614E-2
2.142E-1
6.793E-1
 1 39
12 hsa-miR-4704-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.401E-3 3.614E-2
2.142E-1
7.141E-1
 1 41
13 hsa-miR-99b:mirSVR highEffct hsa-miR-99b:mirSVR conserved highEffect-0.5 MicroRNA.org 3.815E-3 3.614E-2
2.142E-1
8.011E-1
 1 46
14 hsa-miR-3912-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 3.614E-2
2.142E-1
9.227E-1
 1 53
15 hsa-miR-3667-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 3.614E-2
2.142E-1
9.227E-1
 1 53
16 hsa-miR-487a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.477E-3 3.614E-2
2.142E-1
9.401E-1
 1 54
17 hsa-miR-556-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.477E-3 3.614E-2
2.142E-1
9.401E-1
 1 54
18 hsa-miR-3136-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.614E-2
2.142E-1
9.749E-1
 1 56
19 hsa-miR-26a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.890E-3 3.614E-2
2.142E-1
1.000E0
 1 59
20 hsa-miR-1915-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 3.614E-2
2.142E-1
1.000E0
 1 61
21 GTATGAT,MIR-154:MSigDB GTATGAT,MIR-154:MSigDB MSigDB 5.221E-3 3.614E-2
2.142E-1
1.000E0
 1 63
22 GTATGAT,MIR-487:MSigDB GTATGAT,MIR-487:MSigDB MSigDB 5.221E-3 3.614E-2
2.142E-1
1.000E0
 1 63
23 hsa-miR-4313:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 3.614E-2
2.142E-1
1.000E0
 1 68
24 hsa-miR-26a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.883E-3 3.614E-2
2.142E-1
1.000E0
 1 71
25 hsa-miR-554:PITA hsa-miR-554:PITA TOP PITA 5.883E-3 3.614E-2
2.142E-1
1.000E0
 1 71
26 hsa-miR-5702:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.614E-2
2.142E-1
1.000E0
 1 75
27 hsa-miR-323-5p:PITA hsa-miR-323-5p:PITA TOP PITA 6.378E-3 3.614E-2
2.142E-1
1.000E0
 1 77
28 hsa-miR-4660:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.626E-3 3.614E-2
2.142E-1
1.000E0
 1 80
29 hsa-miR-339-5p:PITA hsa-miR-339-5p:PITA TOP PITA 6.791E-3 3.614E-2
2.142E-1
1.000E0
 1 82
30 hsa-miR-4714-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.122E-3 3.614E-2
2.142E-1
1.000E0
 1 86
31 hsa-miR-5047:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.369E-3 3.614E-2
2.142E-1
1.000E0
 1 89
32 hsa-miR-596:PITA hsa-miR-596:PITA TOP PITA 7.782E-3 3.614E-2
2.142E-1
1.000E0
 1 94
33 hsa-miR-219-1-3p:PITA hsa-miR-219-1-3p:PITA TOP PITA 8.030E-3 3.614E-2
2.142E-1
1.000E0
 1 97
34 hsa-miR-655-3p:Functional MTI Functional MTI miRTarbase 8.360E-3 3.614E-2
2.142E-1
1.000E0
 1 101
35 hsa-let-7e*:mirSVR highEffct hsa-let-7e*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.360E-3 3.614E-2
2.142E-1
1.000E0
 1 101
36 hsa-miR-134-5p:Functional MTI Functional MTI miRTarbase 8.360E-3 3.614E-2
2.142E-1
1.000E0
 1 101
37 hsa-miR-1185:PITA hsa-miR-1185:PITA TOP PITA 8.607E-3 3.614E-2
2.142E-1
1.000E0
 1 104
38 hsa-miR-3691-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 3.614E-2
2.142E-1
1.000E0
 1 105
39 hsa-miR-491-5p:PITA hsa-miR-491-5p:PITA TOP PITA 8.854E-3 3.614E-2
2.142E-1
1.000E0
 1 107
40 hsa-miR-199b-5p:Functional MTI Functional MTI miRTarbase 9.184E-3 3.614E-2
2.142E-1
1.000E0
 1 111
41 hsa-miR-877:PITA hsa-miR-877:PITA TOP PITA 9.431E-3 3.614E-2
2.142E-1
1.000E0
 1 114
42 hsa-miR-6801-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.431E-3 3.614E-2
2.142E-1
1.000E0
 1 114
43 hsa-miR-875-5p:PITA hsa-miR-875-5p:PITA TOP PITA 9.431E-3 3.614E-2
2.142E-1
1.000E0
 1 114
44 hsa-miR-3944-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.679E-3 3.614E-2
2.142E-1
1.000E0
 1 117
45 hsa-miR-589:PITA hsa-miR-589:PITA TOP PITA 9.761E-3 3.614E-2
2.142E-1
1.000E0
 1 118
46 hsa-miR-4309:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.843E-3 3.614E-2
2.142E-1
1.000E0
 1 119
47 hsa-miR-610:PITA hsa-miR-610:PITA TOP PITA 9.926E-3 3.614E-2
2.142E-1
1.000E0
 1 120
48 hsa-miR-3198:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.001E-2 3.614E-2
2.142E-1
1.000E0
 1 121
49 hsa-miR-154-3p:TargetScan hsa-miR-154-3p TargetScan 1.001E-2 3.614E-2
2.142E-1
1.000E0
 1 121
50 hsa-miR-487a-3p:TargetScan hsa-miR-487a-3p TargetScan 1.001E-2 3.614E-2
2.142E-1
1.000E0
 1 121
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2766 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4343 DN Dantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.166E-5 5.716E-3 4.860E-2 3.225E-2 3 193
2 4341 DN Vincamine [1617-90-9]; Down 200; 11.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.184E-5 5.716E-3 4.860E-2 3.275E-2 3 194
3 5451 UP Alfaxalone [23930-19-0]; Up 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.203E-5 5.716E-3 4.860E-2 3.326E-2 3 195
4 990 UP alpha-estradiol; Up 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 1.221E-5 5.716E-3 4.860E-2 3.378E-2 3 196
5 7139 DN Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.221E-5 5.716E-3 4.860E-2 3.378E-2 3 196
6 3316 UP Pirenperone [ 75444-65-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.240E-5 5.716E-3 4.860E-2 3.429E-2 3 197
7 CID000088656 Trp-Trp Stitch 6.726E-5 1.819E-2
1.547E-1
1.860E-1
 2 49
8 CID000105082 AC1L2Y08 Stitch 1.288E-4 1.819E-2
1.547E-1
3.562E-1
 3 432
9 CID005393156 7-hydroxy-5-methylflavone Stitch 2.627E-4 1.819E-2
1.547E-1
7.266E-1
 1 1
10 CID012486889 benzo[h]chromen-4-one Stitch 2.627E-4 1.819E-2
1.547E-1
7.266E-1
 1 1
11 CID000637168 tartrolone C Stitch 2.627E-4 1.819E-2
1.547E-1
7.266E-1
 1 1
12 CID000230054 N-benzyl carbamate Stitch 5.253E-4 1.819E-2
1.547E-1
1.000E0
 1 2
13 ctd:D010621 Phenazopyridine CTD 5.253E-4 1.819E-2
1.547E-1
1.000E0
 1 2
14 CID000006946 2-nitroaniline Stitch 5.428E-4 1.819E-2
1.547E-1
1.000E0
 2 139
15 CID000000251 Biliverdin hydrochloride Stitch 6.916E-4 1.819E-2
1.547E-1
1.000E0
 2 157
16 ctd:C011889 kavain CTD 7.879E-4 1.819E-2
1.547E-1
1.000E0
 1 3
17 CID000457943 NSC-643735 Stitch 7.879E-4 1.819E-2
1.547E-1
1.000E0
 1 3
18 CID000000557 hygric acid Stitch 7.879E-4 1.819E-2
1.547E-1
1.000E0
 1 3
19 CID000402597 NSC716727 Stitch 7.879E-4 1.819E-2
1.547E-1
1.000E0
 1 3
20 CID005280443 apigenin Stitch 9.478E-4 1.819E-2
1.547E-1
1.000E0
 2 184
21 4445 UP Rapamycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.580E-4 1.819E-2
1.547E-1
1.000E0
 2 185
22 4578 DN Apigenin [520-36-5]; Down 200; 14.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 9.683E-4 1.819E-2
1.547E-1
1.000E0
 2 186
23 2854 UP Lovastatin [75330-75-5]; Up 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.891E-4 1.819E-2
1.547E-1
1.000E0
 2 188
24 4456 DN troglitazone; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 9.891E-4 1.819E-2
1.547E-1
1.000E0
 2 188
25 4464 UP 2-propylpentanoic acid; Up 200; 500uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.995E-4 1.819E-2
1.547E-1
1.000E0
 2 189
26 ctd:C017557 nickel subsulfide CTD 9.995E-4 1.819E-2
1.547E-1
1.000E0
 2 189
27 7438 UP Isotretinoin [4759-48-2]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 9.995E-4 1.819E-2
1.547E-1
1.000E0
 2 189
28 3975 DN Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.021E-3 1.819E-2
1.547E-1
1.000E0
 2 191
29 3861 UP Proglumide [6620-60-6]; Up 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.021E-3 1.819E-2
1.547E-1
1.000E0
 2 191
30 4496 DN Pindolol [13523-86-9]; Down 200; 16.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.031E-3 1.819E-2
1.547E-1
1.000E0
 2 192
31 2722 DN Cinoxacin [28657-80-9]; Down 200; 15.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.031E-3 1.819E-2
1.547E-1
1.000E0
 2 192
32 4334 DN 0317956-0000 [391210-11-0]; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.031E-3 1.819E-2
1.547E-1
1.000E0
 2 192
33 3375 DN Ethaverine hydrochloride [985-13-7]; Down 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.031E-3 1.819E-2
1.547E-1
1.000E0
 2 192
34 1792 UP Meticrane [1084-65-7]; Up 200; 14.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.042E-3 1.819E-2
1.547E-1
1.000E0
 2 193
35 3715 UP Delcorine; Up 200; 8.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.042E-3 1.819E-2
1.547E-1
1.000E0
 2 193
36 2842 UP Tolazamide [1156-19-0]; Up 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.042E-3 1.819E-2
1.547E-1
1.000E0
 2 193
37 CID003036201 IDETA Stitch 1.050E-3 1.819E-2
1.547E-1
1.000E0
 1 4
38 CID005316743 dihydrotanshinone I Stitch 1.050E-3 1.819E-2
1.547E-1
1.000E0
 1 4
39 CID006450093 NodRm-1 Stitch 1.050E-3 1.819E-2
1.547E-1
1.000E0
 1 4
40 CID000175460 TA-60 Stitch 1.050E-3 1.819E-2
1.547E-1
1.000E0
 1 4
41 CID000099299 aclacinomycin B Stitch 1.050E-3 1.819E-2
1.547E-1
1.000E0
 1 4
42 CID003081166 ENP5 Stitch 1.050E-3 1.819E-2
1.547E-1
1.000E0
 1 4
43 3846 UP Ethoxyquin [91-53-2]; Up 200; 18.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
44 4492 DN Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
45 4772 DN Galanthamine hydrobromide [1953-04-4]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
46 4319 DN Spiramycin [8025-81-8]; Down 200; 4.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
47 4612 DN Capsaicin [404-86-4]; Down 200; 13uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
48 3606 DN Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
49 6380 DN STOCK1N-35215; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
50 1278 UP Tacrine hydrochloride hydrate [1684-40-8]; Up 200; 15.8uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.053E-3 1.819E-2
1.547E-1
1.000E0
 2 194
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 379 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:125370 DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY; DRPLA OMIM 3.703E-4 2.496E-2
1.627E-1
1.403E-1
 1 1
2 C0747733 Polychondritis DisGeNET BeFree 3.703E-4 2.496E-2
1.627E-1
1.403E-1
 1 1
3 C1857788 Atrophy of the dentate nucleus DisGeNET Curated 3.703E-4 2.496E-2
1.627E-1
1.403E-1
 1 1
4 cv:C0751781 Dentatorubral pallidoluysian atrophy Clinical Variations 3.703E-4 2.496E-2
1.627E-1
1.403E-1
 1 1
5 C0032453 Polychondritis, Relapsing DisGeNET BeFree 3.703E-4 2.496E-2
1.627E-1
1.403E-1
 1 1
6 C0020456 Hyperglycemia DisGeNET Curated 3.997E-4 2.496E-2
1.627E-1
1.515E-1
 3 450
7 C0879615 Stromal Neoplasm DisGeNET BeFree 4.610E-4 2.496E-2
1.627E-1
1.747E-1
 2 91
8 C0155223 Dacryoadenitis DisGeNET BeFree 7.404E-4 2.630E-2
1.714E-1
2.806E-1
 1 2
9 C0008439 Chondritis DisGeNET BeFree 7.404E-4 2.630E-2
1.714E-1
2.806E-1
 1 2
10 C0156372 Asherman Syndrome DisGeNET BeFree 7.404E-4 2.630E-2
1.714E-1
2.806E-1
 1 2
11 C0041956 Ureteral obstruction DisGeNET Curated 9.095E-4 2.630E-2
1.714E-1
3.447E-1
 2 128
12 C3714948 PACHYONYCHIA CONGENITA 3 DisGeNET Curated 1.041E-3 2.630E-2
1.714E-1
3.945E-1
 2 137
13 C0036093 Salivary Gland Diseases DisGeNET Curated 1.110E-3 2.630E-2
1.714E-1
4.209E-1
 1 3
14 C0456702 Severe childhood autosomal recessive muscular dystrophy DisGeNET BeFree 1.110E-3 2.630E-2
1.714E-1
4.209E-1
 1 3
15 C0085132 Mucopolysaccharidosis VII DisGeNET Curated 1.110E-3 2.630E-2
1.714E-1
4.209E-1
 1 3
16 C1332655 C3 Deficiency DisGeNET BeFree 1.110E-3 2.630E-2
1.714E-1
4.209E-1
 1 3
17 C4273988 Benign adult familial myoclonic epilepsy DisGeNET BeFree 1.480E-3 2.804E-2
1.827E-1
5.610E-1
 1 4
18 C0270913 Charcot-Marie-Tooth disease, Type 1C DisGeNET Curated 1.480E-3 2.804E-2
1.827E-1
5.610E-1
 1 4
19 C0677607 Hashimoto Disease DisGeNET Curated 1.559E-3 2.804E-2
1.827E-1
5.910E-1
 2 168
20 C0017152 Gastritis DisGeNET Curated 1.671E-3 2.804E-2
1.827E-1
6.335E-1
 2 174
21 C0850758 Pelvic pain female DisGeNET BeFree 1.850E-3 2.804E-2
1.827E-1
7.012E-1
 1 5
22 C0030794 Pelvic Pain DisGeNET BeFree 1.850E-3 2.804E-2
1.827E-1
7.012E-1
 1 5
23 C0266054 Premature tooth eruption DisGeNET Curated 1.850E-3 2.804E-2
1.827E-1
7.012E-1
 1 5
24 C0010606 Adenoid Cystic Carcinoma DisGeNET Curated 1.907E-3 2.804E-2
1.827E-1
7.227E-1
 2 186
25 C0032463 Polycythemia Vera DisGeNET Curated 2.136E-3 2.804E-2
1.827E-1
8.095E-1
 2 197
26 C0022790 Krukenberg Tumor DisGeNET BeFree 2.220E-3 2.804E-2
1.827E-1
8.413E-1
 1 6
27 C3647143 Secondary malignant neoplasm of ovary DisGeNET BeFree 2.220E-3 2.804E-2
1.827E-1
8.413E-1
 1 6
28 C0410173 Severe autosomal recessive muscular dystrophy of childhood - North African type (disorder) DisGeNET Curated 2.220E-3 2.804E-2
1.827E-1
8.413E-1
 1 6
29 C0238246 Hemangioma of liver DisGeNET BeFree 2.220E-3 2.804E-2
1.827E-1
8.413E-1
 1 6
30 C1336078 Papillary renal cell carcinoma, sporadic DisGeNET BeFree 2.220E-3 2.804E-2
1.827E-1
8.413E-1
 1 6
31 C0404484 Chronic pelvic pain of female DisGeNET BeFree 2.589E-3 3.113E-2
2.029E-1
9.814E-1
 1 7
32 C0220633 Uveal melanoma DisGeNET Curated 2.655E-3 3.113E-2
2.029E-1
1.000E0
 2 220
33 C1332884 Central nervous system leukaemia DisGeNET BeFree 2.959E-3 3.113E-2
2.029E-1
1.000E0
 1 8
34 C0265673 Congenital kyphosis DisGeNET BeFree 2.959E-3 3.113E-2
2.029E-1
1.000E0
 1 8
35 C1845118 SHORT STATURE, IDIOPATHIC, X-LINKED DisGeNET Curated 2.959E-3 3.113E-2
2.029E-1
1.000E0
 1 8
36 C0003460 Anuria DisGeNET Curated 2.959E-3 3.113E-2
2.029E-1
1.000E0
 1 8
37 C0519030 Pneumonia due to Klebsiella pneumoniae DisGeNET BeFree 3.328E-3 3.113E-2
2.029E-1
1.000E0
 1 9
38 C0004623 Bacterial Infections DisGeNET Curated 3.631E-3 3.113E-2
2.029E-1
1.000E0
 2 258
39 C0008441 Chondroblastoma DisGeNET Curated 3.697E-3 3.113E-2
2.029E-1
1.000E0
 1 10
40 C0162679 Leukemic Infiltration DisGeNET BeFree 3.697E-3 3.113E-2
2.029E-1
1.000E0
 1 10
41 C3542021 Duchenne and Becker Muscular Dystrophy DisGeNET BeFree 3.697E-3 3.113E-2
2.029E-1
1.000E0
 1 10
42 C4045991 Perihilar Cholangiocarcinoma DisGeNET BeFree 3.697E-3 3.113E-2
2.029E-1
1.000E0
 1 10
43 C1334978 Non-Hereditary Clear Cell Renal Cell Carcinoma DisGeNET BeFree 3.697E-3 3.113E-2
2.029E-1
1.000E0
 1 10
44 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 3.742E-3 3.113E-2
2.029E-1
1.000E0
 2 262
45 C0856169 Endothelial dysfunction DisGeNET BeFree 3.770E-3 3.113E-2
2.029E-1
1.000E0
 2 263
46 C0025205 Melanoma, Experimental DisGeNET Curated 4.067E-3 3.113E-2
2.029E-1
1.000E0
 1 11
47 C0349658 Trichoepithelioma DisGeNET BeFree 4.067E-3 3.113E-2
2.029E-1
1.000E0
 1 11
48 C3275124 Biliary System Disorder DisGeNET BeFree 4.067E-3 3.113E-2
2.029E-1
1.000E0
 1 11
49 C0238284 Acute mountain sickness DisGeNET BeFree 4.067E-3 3.113E-2
2.029E-1
1.000E0
 1 11
50 C3203102 Idiopathic pulmonary arterial hypertension DisGeNET Curated 4.203E-3 3.113E-2
2.029E-1
1.000E0
 2 278
Show 45 more annotations