Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc217_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 51 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990444 F-box domain binding 3.215E-4 1.640E-2
7.410E-2
 1.640E-2 1 1
2 GO:0015631 tubulin binding 3.535E-3 4.257E-2
1.923E-1
1.803E-1
 2 293
3 GO:1990381 ubiquitin-specific protease binding 3.853E-3 4.257E-2
1.923E-1
1.965E-1
 1 12
4 GO:0097602 cullin family protein binding 3.853E-3 4.257E-2
1.923E-1
1.965E-1
 1 12
5 GO:0004859 phospholipase inhibitor activity 4.173E-3 4.257E-2
1.923E-1
2.128E-1
 1 13
6 GO:0055102 lipase inhibitor activity 5.774E-3 4.896E-2
2.213E-1
2.945E-1
 1 18
7 GO:0043274 phospholipase binding 7.054E-3 4.896E-2
2.213E-1
3.597E-1
 1 22
8 GO:0043015 gamma-tubulin binding 8.651E-3 4.896E-2
2.213E-1
4.412E-1
 1 27
9 GO:0043014 alpha-tubulin binding 9.289E-3 4.896E-2
2.213E-1
4.738E-1
 1 29
10 GO:0031624 ubiquitin conjugating enzyme binding 1.056E-2 4.896E-2
2.213E-1
5.388E-1
 1 33
11 GO:0030544 Hsp70 protein binding 1.088E-2 4.896E-2
2.213E-1
5.551E-1
 1 34
12 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1.152E-2 4.896E-2
2.213E-1
5.876E-1
 1 36
Show 7 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 574 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane 1.815E-6 1.042E-3 7.222E-3 1.042E-3 2 7
2 GO:0034620 cellular response to unfolded protein 7.011E-6 1.599E-3 1.108E-2 4.025E-3 3 133
3 GO:0035967 cellular response to topologically incorrect protein 8.357E-6 1.599E-3 1.108E-2 4.797E-3 3 141
4 GO:0006986 response to unfolded protein 1.571E-5 2.132E-3 1.477E-2 9.015E-3 3 174
5 GO:0035966 response to topologically incorrect protein 1.857E-5 2.132E-3 1.477E-2 1.066E-2 3 184
6 GO:0034976 response to endoplasmic reticulum stress 5.520E-5 5.281E-3 3.660E-2 3.169E-2 3 265
7 GO:0036498 IRE1-mediated unfolded protein response 1.895E-4 1.554E-2
1.077E-1
1.088E-1
 2 67
8 GO:1902283 negative regulation of primary amine oxidase activity 3.222E-4 1.890E-2
1.310E-1
1.849E-1
 1 1
9 GO:0006613 cotranslational protein targeting to membrane 4.307E-4 1.890E-2
1.310E-1
2.472E-1
 2 101
10 GO:0045047 protein targeting to ER 4.392E-4 1.890E-2
1.310E-1
2.521E-1
 2 102
11 GO:0072599 establishment of protein localization to endoplasmic reticulum 4.743E-4 1.890E-2
1.310E-1
2.722E-1
 2 106
12 GO:0036483 neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
13 GO:1904049 negative regulation of spontaneous neurotransmitter secretion 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
14 GO:1902528 regulation of protein linear polyubiquitination 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
15 GO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
16 GO:1902530 positive regulation of protein linear polyubiquitination 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
17 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
18 GO:1903381 regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
19 GO:1904048 regulation of spontaneous neurotransmitter secretion 6.443E-4 1.890E-2
1.310E-1
3.698E-1
 1 2
20 GO:0070972 protein localization to endoplasmic reticulum 6.587E-4 1.890E-2
1.310E-1
3.781E-1
 2 125
21 GO:0030968 endoplasmic reticulum unfolded protein response 7.122E-4 1.947E-2
1.349E-1
4.088E-1
 2 130
22 GO:2000313 regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation 9.663E-4 2.133E-2
1.479E-1
5.546E-1
 1 3
23 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 9.663E-4 2.133E-2
1.479E-1
5.546E-1
 1 3
24 GO:0010636 positive regulation of mitochondrial fusion 9.663E-4 2.133E-2
1.479E-1
5.546E-1
 1 3
25 GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation 9.663E-4 2.133E-2
1.479E-1
5.546E-1
 1 3
26 GO:0090258 negative regulation of mitochondrial fission 9.663E-4 2.133E-2
1.479E-1
5.546E-1
 1 3
27 GO:1903223 positive regulation of oxidative stress-induced neuron death 1.288E-3 2.695E-2
1.868E-1
7.394E-1
 1 4
28 GO:0006612 protein targeting to membrane 1.575E-3 2.695E-2
1.868E-1
9.043E-1
 2 194
29 GO:0044314 protein K27-linked ubiquitination 1.610E-3 2.695E-2
1.868E-1
9.242E-1
 1 5
30 GO:0051582 positive regulation of neurotransmitter uptake 1.610E-3 2.695E-2
1.868E-1
9.242E-1
 1 5
31 GO:0035519 protein K29-linked ubiquitination 1.610E-3 2.695E-2
1.868E-1
9.242E-1
 1 5
32 GO:0010637 negative regulation of mitochondrial fusion 1.610E-3 2.695E-2
1.868E-1
9.242E-1
 1 5
33 GO:0097039 protein linear polyubiquitination 1.610E-3 2.695E-2
1.868E-1
9.242E-1
 1 5
34 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.610E-3 2.695E-2
1.868E-1
9.242E-1
 1 5
35 GO:0010918 positive regulation of mitochondrial membrane potential 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
36 GO:0061669 spontaneous neurotransmitter secretion 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
37 GO:0098814 spontaneous synaptic transmission 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
38 GO:0051005 negative regulation of lipoprotein lipase activity 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
39 GO:0070842 aggresome assembly 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
40 GO:0010994 free ubiquitin chain polymerization 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
41 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1.932E-3 2.695E-2
1.868E-1
1.000E0
 1 6
42 GO:0032872 regulation of stress-activated MAPK cascade 2.056E-3 2.695E-2
1.868E-1
1.000E0
 2 222
43 GO:0070302 regulation of stress-activated protein kinase signaling cascade 2.074E-3 2.695E-2
1.868E-1
1.000E0
 2 223
44 GO:0044828 negative regulation by host of viral genome replication 2.253E-3 2.695E-2
1.868E-1
1.000E0
 1 7
45 GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2.253E-3 2.695E-2
1.868E-1
1.000E0
 1 7
46 GO:0021999 neural plate anterior/posterior regionalization 2.253E-3 2.695E-2
1.868E-1
1.000E0
 1 7
47 GO:0010519 negative regulation of phospholipase activity 2.253E-3 2.695E-2
1.868E-1
1.000E0
 1 7
48 GO:2001171 positive regulation of ATP biosynthetic process 2.253E-3 2.695E-2
1.868E-1
1.000E0
 1 7
49 GO:0060897 neural plate regionalization 2.575E-3 2.716E-2
1.883E-1
1.000E0
 1 8
50 GO:0085020 protein K6-linked ubiquitination 2.575E-3 2.716E-2
1.883E-1
1.000E0
 1 8
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 33 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016235 aggresome 4.891E-5 1.614E-3 6.599E-3 1.614E-3 2 35
2 GO:0016234 inclusion body 2.208E-4 3.643E-3 1.490E-2 7.286E-3 2 74
3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex 9.441E-4 1.038E-2 4.245E-2 3.115E-2 1 3
4 GO:0097413 Lewy body 1.573E-3 1.038E-2 4.245E-2
5.191E-2
 1 5
5 GO:0071797 LUBAC complex 1.573E-3 1.038E-2 4.245E-2
5.191E-2
 1 5
6 GO:0034451 centriolar satellite 7.845E-3 4.315E-2
1.764E-1
2.589E-1
 1 25
Show 1 more annotation

4: Human Phenotype [Display Chart] 4 input genes in category / 573 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001407 Hepatic cysts 4.212E-5 2.414E-2
1.672E-1
 2.414E-2 2 13

5: Mouse Phenotype [Display Chart] 4 input genes in category / 214 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 53 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF16045 LisH 2 Pfam 3.203E-4 3.395E-3 1.547E-2 1.697E-2 1 1
2 IPR003977 Parkin InterPro 3.203E-4 3.395E-3 1.547E-2 1.697E-2 1 1
3 PF03839 Sec62 Pfam 3.203E-4 3.395E-3 1.547E-2 1.697E-2 1 1
4 IPR004728 Sec62 InterPro 3.203E-4 3.395E-3 1.547E-2 1.697E-2 1 1
5 IPR028152 IL-26 InterPro 3.203E-4 3.395E-3 1.547E-2 1.697E-2 1 1
6 PF02889 Sec63 Pfam 1.281E-3 6.787E-3 3.093E-2
6.787E-2
 1 4
7 SM00973 Sec63 SMART 1.281E-3 6.787E-3 3.093E-2
6.787E-2
 1 4
8 PF00726 IL10 Pfam 1.281E-3 6.787E-3 3.093E-2
6.787E-2
 1 4
9 IPR004179 Sec63-dom InterPro 1.281E-3 6.787E-3 3.093E-2
6.787E-2
 1 4
10 SM00188 IL10 SMART 1.281E-3 6.787E-3 3.093E-2
6.787E-2
 1 4
11 PS00520 INTERLEUKIN 10 PROSITE 1.920E-3 7.270E-3 3.313E-2
1.018E-1
 1 6
12 IPR020423 IL-10 CS InterPro 1.920E-3 7.270E-3 3.313E-2
1.018E-1
 1 6
13 IPR020443 IL-10/19/20/22/24/26 fam InterPro 1.920E-3 7.270E-3 3.313E-2
1.018E-1
 1 6
14 IPR000098 IL-10 InterPro 1.920E-3 7.270E-3 3.313E-2
1.018E-1
 1 6
15 PF08513 LisH Pfam 2.879E-3 1.017E-2 4.636E-2
1.526E-1
 1 9
16 IPR031127 E3 UB ligase RBR InterPro 3.199E-3 1.060E-2 4.828E-2
1.695E-1
 1 10
17 PF01485 IBR Pfam 4.476E-3 1.318E-2
6.005E-2
2.372E-1
 1 14
18 SM00647 IBR SMART 4.476E-3 1.318E-2
6.005E-2
2.372E-1
 1 14
19 IPR002867 IBR dom InterPro 4.795E-3 1.338E-2
6.095E-2
2.541E-1
 1 15
20 IPR014715 Fibrinogen a/b/g C 2 InterPro 7.663E-3 1.745E-2
7.951E-2
4.061E-1
 1 24
21 4.10.530.10 - Gene3D 7.663E-3 1.745E-2
7.951E-2
4.061E-1
 1 24
22 PF00147 Fibrinogen C Pfam 8.617E-3 1.745E-2
7.951E-2
4.567E-1
 1 27
23 SM00667 LisH SMART 8.935E-3 1.745E-2
7.951E-2
4.736E-1
 1 28
24 PS50896 LISH PROSITE 8.935E-3 1.745E-2
7.951E-2
4.736E-1
 1 28
25 IPR006594 LisH InterPro 8.935E-3 1.745E-2
7.951E-2
4.736E-1
 1 28
26 SM00186 FBG SMART 9.253E-3 1.745E-2
7.951E-2
4.904E-1
 1 29
27 3.90.215.10 - Gene3D 9.571E-3 1.745E-2
7.951E-2
5.072E-1
 1 30
28 IPR014716 Fibrinogen a/b/g C 1 InterPro 9.571E-3 1.745E-2
7.951E-2
5.072E-1
 1 30
29 PS00514 FIBRINOGEN C 1 PROSITE 1.021E-2 1.745E-2
7.951E-2
5.409E-1
 1 32
30 PS51406 FIBRINOGEN C 2 PROSITE 1.021E-2 1.745E-2
7.951E-2
5.409E-1
 1 32
31 IPR002181 Fibrinogen a/b/g C dom InterPro 1.021E-2 1.745E-2
7.951E-2
5.409E-1
 1 32
32 PS00299 UBIQUITIN 1 PROSITE 1.179E-2 1.953E-2
8.900E-2
6.250E-1
 1 37
33 SM00213 UBQ SMART 1.369E-2 2.047E-2
9.330E-2
7.258E-1
 1 43
34 PF00240 ubiquitin Pfam 1.496E-2 2.047E-2
9.330E-2
7.929E-1
 1 47
35 PF00226 DnaJ Pfam 1.528E-2 2.047E-2
9.330E-2
8.096E-1
 1 48
36 PS50076 DNAJ 2 PROSITE 1.559E-2 2.047E-2
9.330E-2
8.264E-1
 1 49
37 SM00271 DnaJ SMART 1.559E-2 2.047E-2
9.330E-2
8.264E-1
 1 49
38 PS00636 DNAJ 1 PROSITE 1.559E-2 2.047E-2
9.330E-2
8.264E-1
 1 49
39 1.10.287.110 - Gene3D 1.559E-2 2.047E-2
9.330E-2
8.264E-1
 1 49
40 1.20.1250.10 - Gene3D 1.591E-2 2.047E-2
9.330E-2
8.431E-1
 1 50
41 IPR012351 4 helix cytokine core InterPro 1.622E-2 2.047E-2
9.330E-2
8.599E-1
 1 51
42 IPR001623 DnaJ domain InterPro 1.622E-2 2.047E-2
9.330E-2
8.599E-1
 1 51
43 PS50053 UBIQUITIN 2 PROSITE 1.717E-2 2.117E-2
9.645E-2
9.101E-1
 1 54
44 IPR000626 Ubiquitin dom InterPro 1.843E-2 2.220E-2
1.012E-1
9.770E-1
 1 58
45 IPR009079 4 helix cytokine-like core InterPro 2.347E-2 2.764E-2
1.260E-1
1.000E0
 1 74
46 IPR014756 Ig E-set InterPro 3.285E-2 3.785E-2
1.725E-1
1.000E0
 1 104
Show 41 more annotations

7: Pathway [Display Chart] 6 input genes in category / 41 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 4.521E-5 9.994E-4 4.300E-3 1.854E-3 3 166
2 83041 Protein export BioSystems: KEGG 4.875E-5 9.994E-4 4.300E-3 1.999E-3 2 23
3 1268760 XBP1(S) activates chaperone genes BioSystems: REACTOME 3.053E-4 3.353E-3 1.443E-2 1.252E-2 2 57
4 1268759 IRE1alpha activates chaperones BioSystems: REACTOME 3.272E-4 3.353E-3 1.443E-2 1.341E-2 2 59
5 1268756 Unfolded Protein Response (UPR) BioSystems: REACTOME 8.120E-4 6.659E-3 2.865E-2 3.329E-2 2 93
6 PW:0000010 lipid metabolic Pathway Ontology 1.927E-3 1.234E-2
5.310E-2
7.899E-2
 1 4
7 PW:0000294 altered ubiquitin/proteasome degradation Pathway Ontology 2.408E-3 1.234E-2
5.310E-2
9.872E-2
 1 5
8 PW:0000144 ubiquitin/proteasome degradation Pathway Ontology 2.408E-3 1.234E-2
5.310E-2
9.872E-2
 1 5
9 M13917 Role of Parkin in the Ubiquitin-Proteasomal Pathway MSigDB C2 BIOCARTA (v6.0) 5.770E-3 2.366E-2
1.018E-1
2.366E-1
 1 12
10 1427864 Josephin domain DUBs BioSystems: REACTOME 5.770E-3 2.366E-2
1.018E-1
2.366E-1
 1 12
11 PW:0000018 Parkinson disease Pathway Ontology 7.688E-3 2.865E-2
1.233E-1
3.152E-1
 1 16
12 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 1.061E-2 3.232E-2
1.391E-1
4.349E-1
 2 344
13 1309218 Mitophagy BioSystems: REACTOME 1.104E-2 3.232E-2
1.391E-1
4.525E-1
 1 23
14 1309219 Pink/Parkin Mediated Mitophagy BioSystems: REACTOME 1.104E-2 3.232E-2
1.391E-1
4.525E-1
 1 23
15 1270006 Chylomicron-mediated lipid transport BioSystems: REACTOME 1.342E-2 3.668E-2
1.578E-1
5.503E-1
 1 28
16 137913 Alpha-synuclein signaling BioSystems: Pathway Interaction Database 1.533E-2 3.927E-2
1.690E-1
6.284E-1
 1 32
Show 11 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1155 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23287549 CK2 phosphorylation of human Sec63 regulates its interaction with Sec62. Pubmed 6.170E-8 3.563E-5 2.718E-4 7.126E-5 2 3
2 10799540 Mammalian Sec61 is associated with Sec62 and Sec63. Pubmed 6.170E-8 3.563E-5 2.718E-4 7.126E-5 2 3
3 22375059 Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Pubmed 1.603E-6 3.902E-4 2.977E-3 1.851E-3 2 13
4 22028146 Restriction of trophic factors and nutrients induces PARKIN expression. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
5 11179010 Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
6 19464273 Effects of partial suppression of parkin on huntingtin mutant R6/1 mice. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
7 26800306 Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
8 20301651 Parkin Type of Early-Onset Parkinson Disease Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
9 20818665 Fibrocystic disease of liver and pancreas; under-recognized features of the X-linked ciliopathy oral-facial-digital syndrome type 1 (OFD I). Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
10 15300670 Does parkin play a role in the peripheral nervous system? A family report. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
11 19474742 Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: association with insulin resistance. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
12 15063093 Parkin expression in the developing mouse. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
13 15192821 [New polymorphism (IVS3-20 T-->C) of the parkin gene associated with the early-onset Parkinson's disease in Chinese]. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
14 18331811 Brain perfusion abnormalities in a sibship with parkin-linked parkinsonism. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
15 11971093 Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
16 12397156 Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
17 19863651 Somatosensory function in asymptomatic Parkin-mutation carriers. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
18 12362318 [A new point mutation on exon 2 of parkin gene in Parkinson's disease]. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
19 17187375 Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
20 15584030 Novel parkin mutations detected in patients with early-onset Parkinson's disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
21 26202572 Interleukin-26: An Emerging Player in Host Defense and Inflammation. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
22 23262240 Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
23 9731209 Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
24 27590295 Impulsive-compulsive behaviors in parkin-associated Parkinson disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
25 25022755 HSPA1A-independent suppression of PARK2 C289G protein aggregation by human small heat shock proteins. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
26 21915905 Analysis of PARK2 gene exon rearrangements in Russian patients with sporadic Parkinson's disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
27 20620130 Impaired in vivo dopamine release in parkin knockout mice. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
28 14991825 Pael-R is accumulated in Lewy bodies of Parkinson's disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
29 19208265 The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
30 28631565 Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
31 25656612 Expression pattern of parkin isoforms in lung adenocarcinomas. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
32 11179005 Identification of the gene for oral-facial-digital type I syndrome. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
33 25710887 A novel role of angiopoietin-like-3 associated with podocyte injury. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
34 19339245 Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
35 28505061 Novel OFD1 frameshift mutation in a Chinese boy with Joubert syndrome: a case report and literature review. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
36 10939576 Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
37 15823482 Early-onset Parkinson's disease in a Chinese population: 99mTc-TRODAT-1 SPECT, Parkin gene analysis and clinical study. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
38 15229644 How does parkin ligate ubiquitin to Parkinson's disease? Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
39 17687034 Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
40 16941649 Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
41 27297116 Parkin Somatic Mutations Link Melanoma and Parkinson's Disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
42 24192137 Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
43 16227559 Mutational screening of the parkin gene among South Indians with early onset Parkinson's disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
44 19457102 Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
45 26188007 Heterozygote carriers for CNVs in PARK2 are at increased risk of Parkinson's disease. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
46 19540497 Plasma angiopoietin-like protein 3 (ANGPTL3) concentration is associated with uremic dyslipidemia. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
47 15642853 Parkin mutations and early-onset parkinsonism in a Taiwanese cohort. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
48 27798970 Second mutation in PARK2 is absent in patients with sporadic Parkinson's disease and heterozygous exonic deletions/duplications in parkin gene. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
49 24337465 Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
50 30296568 Association of PARK2 promoter polymorphisms and methylation with colorectal cancer in North Indian population. Pubmed 1.571E-4 3.902E-4 2.977E-3
1.814E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 744 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SEC63 SEC63 interactions 2.850E-7 2.121E-4 1.525E-3 2.121E-4 3 44
2 int:SEC62 SEC62 interactions 2.414E-5 8.981E-3
6.458E-2
 1.796E-2 2 23
3 int:GPR183 GPR183 interactions 6.000E-5 1.488E-2
1.070E-1
 4.464E-2 2 36
4 int:TCHP TCHP interactions 1.736E-4 3.230E-2
2.322E-1
1.292E-1
 2 61
5 int:NBN NBN interactions 4.485E-4 4.049E-2
2.911E-1
3.337E-1
 2 98
6 int:AMOT AMOT interactions 6.063E-4 4.049E-2
2.911E-1
4.511E-1
 2 114
7 int:CEP55 CEP55 interactions 6.169E-4 4.049E-2
2.911E-1
4.590E-1
 2 115
8 int:IMPDH2 IMPDH2 interactions 6.604E-4 4.049E-2
2.911E-1
4.913E-1
 2 119
9 int:CALM1P1 CALM1P1 interactions 6.778E-4 4.049E-2
2.911E-1
5.043E-1
 1 2
10 int:AMY2B AMY2B interactions 6.778E-4 4.049E-2
2.911E-1
5.043E-1
 1 2
11 int:IGKV2-30 IGKV2-30 interactions 6.778E-4 4.049E-2
2.911E-1
5.043E-1
 1 2
12 int:IL26 IL26 interactions 6.778E-4 4.049E-2
2.911E-1
5.043E-1
 1 2
13 int:PSMD14 PSMD14 interactions 7.754E-4 4.049E-2
2.911E-1
5.769E-1
 2 129
14 int:PSMD7 PSMD7 interactions 8.116E-4 4.049E-2
2.911E-1
6.038E-1
 2 132
15 int:AIMP2 AIMP2 interactions 8.612E-4 4.049E-2
2.911E-1
6.407E-1
 2 136
16 int:BAG2 BAG2 interactions 8.994E-4 4.049E-2
2.911E-1
6.691E-1
 2 139
17 int:SRSF2 SRSF2 interactions 9.253E-4 4.049E-2
2.911E-1
6.884E-1
 2 141
18 int:GPRC5D GPRC5D interactions 1.016E-3 4.201E-2
3.021E-1
7.563E-1
 1 3
19 int:CCNB1 CCNB1 interactions 1.088E-3 4.261E-2
3.063E-1
8.095E-1
 2 153
Show 14 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q25.2-q27 6q25.2-q27 1.731E-4 1.039E-3 2.545E-3 1.039E-3 1 1
2 Xp22 Xp22 4.665E-3 8.549E-3 2.094E-2 2.799E-2 1 27
3 3q26.2 3q26.2 4.665E-3 8.549E-3 2.094E-2 2.799E-2 1 27
4 12q15 12q15 5.699E-3 8.549E-3 2.094E-2 3.420E-2 1 33
5 1p31.3 1p31.3 9.484E-3 1.138E-2 2.788E-2
5.690E-2
 1 55
6 6q21 6q21 1.770E-2 1.770E-2 4.336E-2
1.062E-1
 1 103
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TMTCGCGANR UNKNOWN TMTCGCGANR UNKNOWN 1.329E-5 3.323E-4 1.268E-3 3.323E-4 3 109

12: Gene Family [Display Chart] 4 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 905 Fibrinogen C domain containing|Angiopoietin like genenames.org 1.758E-3 8.783E-3 2.006E-2 8.789E-3 1 8
2 672 Parkinson disease associated genes|Ubiquitin C-terminal hydrolases genenames.org 3.513E-3 8.783E-3 2.006E-2 1.757E-2 1 16
3 554 Fibrinogen C domain containing|Fibronectin type III domain containing genenames.org 5.485E-3 9.142E-3 2.088E-2 2.743E-2 1 25
4 601 Interleukins|PDZ domain containing genenames.org 9.421E-3 1.073E-2 2.450E-2 4.710E-2 1 43
5 584 DNAJ (HSP40) heat shock proteins genenames.org 1.073E-2 1.073E-2 2.450E-2
5.365E-2
 1 49

13: Coexpression [Display Chart] 6 input genes in category / 392 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2372 Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-1 microRNA. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.678E-5 3.010E-2
1.971E-1
 3.010E-2 2 53

14: Coexpression Atlas [Display Chart] 6 input genes in category / 211 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 3 input genes in category / 19 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M1964 MORF PRKAG1 Neighborhood of PRKAG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.401E-3 2.663E-2
9.446E-2
 2.663E-2 2 219

16: MicroRNA [Display Chart] 6 input genes in category / 275 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-409-3p:TargetScan hsa-miR-409-3p TargetScan 1.514E-4 1.537E-2
9.524E-2
 4.164E-2 2 231
2 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 2.270E-4 1.537E-2
9.524E-2
6.243E-2
 2 283
3 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 2.270E-4 1.537E-2
9.524E-2
6.243E-2
 2 283
4 hsa-miR-6809-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.918E-4 1.537E-2
9.524E-2
8.024E-2
 2 321
5 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 3.892E-4 1.537E-2
9.524E-2
1.070E-1
 2 371
6 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 3.892E-4 1.537E-2
9.524E-2
1.070E-1
 2 371
7 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 3.913E-4 1.537E-2
9.524E-2
1.076E-1
 2 372
8 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 5.763E-4 1.831E-2
1.135E-1
1.585E-1
 2 452
9 hsa-miR-369-3p:TargetScan hsa-miR-369-3p TargetScan 5.993E-4 1.831E-2
1.135E-1
1.648E-1
 2 461
10 hsa-miR-8053:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.245E-3 3.424E-2
2.122E-1
3.424E-1
 1 15
11 hsa-miR-6717-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.909E-3 3.427E-2
2.123E-1
5.249E-1
 1 23
12 hsa-miR-3168:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 3.427E-2
2.123E-1
7.073E-1
 1 31
13 hsa-miR-323b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.649E-3 3.427E-2
2.123E-1
1.000E0
 1 44
14 hsa-miR-6874-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 3.427E-2
2.123E-1
1.000E0
 1 48
15 hsa-miR-148b-5p:Functional MTI Functional MTI miRTarbase 4.311E-3 3.427E-2
2.123E-1
1.000E0
 1 52
16 hsa-miR-4686:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.477E-3 3.427E-2
2.123E-1
1.000E0
 1 54
17 hsa-miR-135b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 3.427E-2
2.123E-1
1.000E0
 1 55
18 hsa-miR-3935:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.427E-2
2.123E-1
1.000E0
 1 56
19 hsa-miR-2117:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.725E-3 3.427E-2
2.123E-1
1.000E0
 1 57
20 hsa-miR-145-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 3.427E-2
2.123E-1
1.000E0
 1 60
21 hsa-miR-4752:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.139E-3 3.427E-2
2.123E-1
1.000E0
 1 62
22 hsa-miR-4639-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 3.427E-2
2.123E-1
1.000E0
 1 63
23 hsa-miR-299-5p:Functional MTI Functional MTI miRTarbase 5.221E-3 3.427E-2
2.123E-1
1.000E0
 1 63
24 hsa-miR-514b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.427E-2
2.123E-1
1.000E0
 1 64
25 hsa-miR-514a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 3.427E-2
2.123E-1
1.000E0
 1 65
26 hsa-miR-4318:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 3.427E-2
2.123E-1
1.000E0
 1 65
27 hsa-miR-520f-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.427E-2
2.123E-1
1.000E0
 1 69
28 hsa-miR-513b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.427E-2
2.123E-1
1.000E0
 1 69
29 hsa-miR-4503:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.883E-3 3.427E-2
2.123E-1
1.000E0
 1 71
30 hsa-miR-4289:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.427E-2
2.123E-1
1.000E0
 1 73
31 hsa-miR-6508-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.427E-2
2.123E-1
1.000E0
 1 75
32 hsa-miR-8067:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.296E-3 3.427E-2
2.123E-1
1.000E0
 1 76
33 hsa-miR-4662a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 3.427E-2
2.123E-1
1.000E0
 1 77
34 hsa-miR-5584-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.544E-3 3.427E-2
2.123E-1
1.000E0
 1 79
35 hsa-miR-4528:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.544E-3 3.427E-2
2.123E-1
1.000E0
 1 79
36 hsa-miR-633:Functional MTI Functional MTI miRTarbase 6.709E-3 3.427E-2
2.123E-1
1.000E0
 1 81
37 AGGCACT,MIR-515-3P:MSigDB AGGCACT,MIR-515-3P:MSigDB MSigDB 7.039E-3 3.427E-2
2.123E-1
1.000E0
 1 85
38 hsa-miR-6516-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 3.427E-2
2.123E-1
1.000E0
 1 85
39 hsa-miR-4802-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 3.427E-2
2.123E-1
1.000E0
 1 85
40 hsa-miR-6833-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 3.427E-2
2.123E-1
1.000E0
 1 91
41 hsa-miR-644a:Functional MTI Functional MTI miRTarbase 7.700E-3 3.427E-2
2.123E-1
1.000E0
 1 93
42 hsa-miR-7845-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.427E-2
2.123E-1
1.000E0
 1 98
43 hsa-miR-1289:PITA hsa-miR-1289:PITA TOP PITA 8.112E-3 3.427E-2
2.123E-1
1.000E0
 1 98
44 hsa-miR-411:PITA hsa-miR-411:PITA TOP PITA 8.277E-3 3.427E-2
2.123E-1
1.000E0
 1 100
45 hsa-miR-1206:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 3.427E-2
2.123E-1
1.000E0
 1 101
46 hsa-miR-497-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 3.427E-2
2.123E-1
1.000E0
 1 101
47 hsa-miR-6792-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.427E-2
2.123E-1
1.000E0
 1 103
48 hsa-miR-151-3p:PITA hsa-miR-151-3p:PITA TOP PITA 8.689E-3 3.427E-2
2.123E-1
1.000E0
 1 105
49 hsa-miR-3674:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.937E-3 3.427E-2
2.123E-1
1.000E0
 1 108
50 hsa-miR-409-3p:Functional MTI Functional MTI miRTarbase 9.184E-3 3.427E-2
2.123E-1
1.000E0
 1 111
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 238 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C089032 rimonabant CTD 3.078E-5 7.325E-3 4.433E-2 7.325E-3 3 267
2 ctd:D002936 Cinnarizine CTD 1.050E-3 4.464E-2
2.701E-1
2.500E-1
 1 4
3 ctd:C070053 carbonyl 3-chlorophenylhydrazone CTD 1.050E-3 4.464E-2
2.701E-1
2.500E-1
 1 4
4 ctd:C106731 3-bromo-7-nitroindazole CTD 1.050E-3 4.464E-2
2.701E-1
2.500E-1
 1 4
5 3234 UP Methyldopa (L,-) [555-30-6]; Up 200; 19uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.096E-3 4.464E-2
2.701E-1
2.609E-1
 2 198
6 CID000514181 phyllanthusiin C Stitch 1.313E-3 4.464E-2
2.701E-1
3.125E-1
 1 5
7 CID000066654 xanthoxyline Stitch 1.313E-3 4.464E-2
2.701E-1
3.125E-1
 1 5
8 CID000188337 putThy Stitch 1.575E-3 4.686E-2
2.836E-1
3.749E-1
 1 6
9 CID003035756 3-F-InsP3 Stitch 1.838E-3 4.859E-2
2.941E-1
4.373E-1
 1 7
Show 4 more annotations

18: Disease [Display Chart] 6 input genes in category / 373 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0267834 Liver cyst DisGeNET Curated 1.743E-5 6.503E-3 4.227E-2 6.503E-3 2 18
2 C0022679 Cystic kidney DisGeNET Curated 2.280E-4 7.673E-3 4.987E-2
8.504E-2
 2 64
3 C0029927 Ovarian Cysts DisGeNET Curated 2.651E-4 7.673E-3 4.987E-2
9.888E-2
 2 69
4 OMIN:600116 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE; PARK2 OMIM 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
5 cv:C1857970 Hypobetalipoproteinemia, familial, 2 Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
6 OMIN:300804 JOUBERT SYNDROME 10; JBTS10 OMIM 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
7 OMIN:311200 OROFACIODIGITAL SYNDROME I; OFD1 OMIM 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
8 cv:C1868675 Parkinson disease 2 Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
9 cv:C1845542 Retinitis Pigmentosa 23 Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
10 C2931426 Orofaciodigital syndrome type1 DisGeNET Curated 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
11 cv:C2749019 Joubert syndrome 10 Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
12 OMIN:300209 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 2 OMIM 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
13 C1846175 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 2 (disorder) DisGeNET Curated 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
14 cv:C1843632 Leprosy 2 Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
15 C1857970 Hypobetalipoproteinemia, Familial, 2 DisGeNET Curated 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
16 C2749019 JOUBERT SYNDROME 10 (disorder) DisGeNET Curated 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
17 cv:C1510460 Oral-facial-digital syndrome Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
18 cv:C1846175 Simpson-Golabi-Behmel syndrome, type 2 Clinical Variations 3.703E-4 7.673E-3 4.987E-2
1.381E-1
 1 1
19 C0022680 Polycystic Kidney Diseases DisGeNET Curated 5.454E-4 9.863E-3
6.411E-2
2.034E-1
 2 99
20 C1865598 Thick alveolar ridges DisGeNET Curated 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
21 C1858545 Facial capillary hemangioma DisGeNET Curated 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
22 C0265251 Oto-Palato-digital syndrome type 1 DisGeNET Curated 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
23 C2936864 Bardet-Biedl syndrome 4 (disorder) DisGeNET Curated 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
24 C1856164 Hypertrophied alveolar ridge DisGeNET Curated 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
25 C0030528 Paratyphoid Fever DisGeNET BeFree 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
26 cv:C0158683 Congenital cystic disease of liver Clinical Variations 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
27 C1856202 U-Shaped upper lip vermilion DisGeNET Curated 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
28 OMIN:174050 POLYCYSTIC LIVER DISEASE; PCLD OMIM 7.404E-4 9.863E-3
6.411E-2
2.762E-1
 1 2
29 C4280675 Broad alveolar processes of jaw DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
30 C1846865 Gliosis in the substantia nigra DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
31 C0752205 Dystonia, Secondary DisGeNET BeFree 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
32 C0241438 Tongue nodules DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
33 C0266111 Bifid tongue DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
34 C4255098 Cleft tongue DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
35 C1857500 Broad alveolar ridges DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
36 C1853445 PARKINSON DISEASE 7, AUTOSOMAL RECESSIVE EARLY-ONSET DisGeNET Curated 1.110E-3 1.151E-2
7.479E-2
4.142E-1
 1 3
37 C0431565 Hamartoma of tongue DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
38 C2674738 Toe abnormalities DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
39 C0524582 Mulibrey Nanism DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
40 C1866129 Cerebellar abnormalities DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
41 C1846176 Hyperactive deep tendon reflexes DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
42 C1859569 BARDET-BIEDL SYNDROME 11 DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
43 C0742038 Cerebellar signs DisGeNET Curated 1.480E-3 1.284E-2
8.347E-2
5.522E-1
 1 4
44 C0853085 Low density lipoprotein decreased DisGeNET Curated 1.850E-3 1.438E-2
9.345E-2
6.901E-1
 1 5
45 C4024979 Ovarian papillary adenocarcinoma DisGeNET Curated 1.850E-3 1.438E-2
9.345E-2
6.901E-1
 1 5
46 C1856019 Abnormal cortical gyration DisGeNET Curated 1.850E-3 1.438E-2
9.345E-2
6.901E-1
 1 5
47 C0266491 Neuronal heterotopia DisGeNET Curated 1.850E-3 1.438E-2
9.345E-2
6.901E-1
 1 5
48 C0431564 Lobulated tongue DisGeNET Curated 1.850E-3 1.438E-2
9.345E-2
6.901E-1
 1 5
49 C0542037 Hypotriglyceridaemia DisGeNET Curated 2.220E-3 1.533E-2
9.967E-2
8.280E-1
 1 6
50 cv:C0919267 Neoplasm of ovary Clinical Variations 2.220E-3 1.533E-2
9.967E-2
8.280E-1
 1 6
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