Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc241_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 63 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031432 titin binding 1.095E-5 6.900E-4 3.263E-3 6.900E-4 2 14
2 GO:0008307 structural constituent of muscle 9.822E-5 3.094E-3 1.463E-2 6.188E-3 2 41
3 GO:0032947 protein-containing complex scaffold activity 3.573E-4 7.504E-3 3.548E-2 2.251E-2 2 78
4 GO:0070080 titin Z domain binding 7.501E-4 1.181E-2
5.585E-2
 4.726E-2 1 2
5 GO:0044325 ion channel binding 9.437E-4 1.181E-2
5.585E-2
5.945E-2
 2 127
6 GO:0051373 FATZ binding 1.125E-3 1.181E-2
5.585E-2
7.087E-2
 1 3
7 GO:0043842 Kdo transferase activity 1.500E-3 1.350E-2
6.382E-2
9.448E-2
 1 4
8 GO:0071253 connexin binding 1.874E-3 1.476E-2
6.979E-2
1.181E-1
 1 5
9 GO:0030957 Tat protein binding 2.998E-3 1.888E-2
8.929E-2
1.888E-1
 1 8
10 GO:0019870 potassium channel inhibitor activity 2.998E-3 1.888E-2
8.929E-2
1.888E-1
 1 8
11 GO:0036122 BMP binding 4.120E-3 2.359E-2
1.116E-1
2.595E-1
 1 11
12 GO:0044183 protein binding involved in protein folding 5.614E-3 2.694E-2
1.274E-1
3.537E-1
 1 15
13 GO:0031402 sodium ion binding 5.987E-3 2.694E-2
1.274E-1
3.772E-1
 1 16
14 GO:0055103 ligase regulator activity 5.987E-3 2.694E-2
1.274E-1
3.772E-1
 1 16
15 GO:0001671 ATPase activator activity 6.734E-3 2.828E-2
1.337E-1
4.242E-1
 1 18
16 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 7.852E-3 3.009E-2
1.423E-1
4.947E-1
 1 21
17 GO:0050998 nitric-oxide synthase binding 8.225E-3 3.009E-2
1.423E-1
5.182E-1
 1 22
18 GO:0031420 alkali metal ion binding 8.597E-3 3.009E-2
1.423E-1
5.416E-1
 1 23
19 GO:0043014 alpha-tubulin binding 1.083E-2 3.591E-2
1.698E-1
6.823E-1
 1 29
20 GO:0060590 ATPase regulator activity 1.194E-2 3.739E-2
1.768E-1
7.525E-1
 1 32
21 GO:0017080 sodium channel regulator activity 1.269E-2 3.739E-2
1.768E-1
7.992E-1
 1 34
22 GO:0031369 translation initiation factor binding 1.306E-2 3.739E-2
1.768E-1
8.226E-1
 1 35
23 GO:0005246 calcium channel regulator activity 1.417E-2 3.817E-2
1.805E-1
8.927E-1
 1 38
24 GO:0008200 ion channel inhibitor activity 1.454E-2 3.817E-2
1.805E-1
9.160E-1
 1 39
25 GO:0016248 channel inhibitor activity 1.528E-2 3.851E-2
1.821E-1
9.627E-1
 1 41
26 GO:0015459 potassium channel regulator activity 1.787E-2 4.330E-2
2.047E-1
1.000E0
 1 48
27 GO:0043621 protein self-association 2.082E-2 4.685E-2
2.215E-1
1.000E0
 1 56
28 GO:0005544 calcium-dependent phospholipid binding 2.082E-2 4.685E-2
2.215E-1
1.000E0
 1 56
Show 23 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 553 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0046716 muscle cell cellular homeostasis 4.313E-8 2.385E-5 1.644E-4 2.385E-5 3 21
2 GO:0045214 sarcomere organization 3.194E-7 8.831E-5 6.088E-4 1.766E-4 3 40
3 GO:0035995 detection of muscle stretch 7.264E-7 1.339E-4 9.230E-4 4.017E-4 2 4
4 GO:0030239 myofibril assembly 1.159E-6 1.603E-4 1.105E-3 6.412E-4 3 61
5 GO:0051146 striated muscle cell differentiation 1.916E-6 2.120E-4 1.461E-3 1.060E-3 4 289
6 GO:0001778 plasma membrane repair 3.387E-6 3.122E-4 2.152E-3 1.873E-3 2 8
7 GO:0007517 muscle organ development 7.324E-6 5.418E-4 3.735E-3 4.050E-3 4 405
8 GO:0042692 muscle cell differentiation 7.838E-6 5.418E-4 3.735E-3 4.335E-3 4 412
9 GO:0031032 actomyosin structure organization 2.204E-5 1.285E-3 8.855E-3 1.219E-2 3 162
10 GO:0055002 striated muscle cell development 2.371E-5 1.285E-3 8.855E-3 1.311E-2 3 166
11 GO:0051147 regulation of muscle cell differentiation 2.637E-5 1.285E-3 8.855E-3 1.458E-2 3 172
12 GO:0035994 response to muscle stretch 2.788E-5 1.285E-3 8.855E-3 1.542E-2 2 22
13 GO:0055001 muscle cell development 3.071E-5 1.306E-3 9.006E-3 1.698E-2 3 181
14 GO:0003009 skeletal muscle contraction 1.086E-4 4.288E-3 2.956E-2
6.003E-2
 2 43
15 GO:0045843 negative regulation of striated muscle tissue development 1.244E-4 4.423E-3 3.049E-2
6.877E-2
 2 46
16 GO:0048635 negative regulation of muscle organ development 1.355E-4 4.423E-3 3.049E-2
7.493E-2
 2 48
17 GO:1901862 negative regulation of muscle tissue development 1.412E-4 4.423E-3 3.049E-2
7.810E-2
 2 49
18 GO:0050881 musculoskeletal movement 1.781E-4 4.423E-3 3.049E-2
9.851E-2
 2 55
19 GO:0050879 multicellular organismal movement 1.781E-4 4.423E-3 3.049E-2
9.851E-2
 2 55
20 GO:0050982 detection of mechanical stimulus 1.914E-4 4.423E-3 3.049E-2
1.058E-1
 2 57
21 GO:0010927 cellular component assembly involved in morphogenesis 1.931E-4 4.423E-3 3.049E-2
1.068E-1
 3 336
22 GO:0051155 positive regulation of striated muscle cell differentiation 2.121E-4 4.423E-3 3.049E-2
1.173E-1
 2 60
23 GO:0006936 muscle contraction 2.141E-4 4.423E-3 3.049E-2
1.184E-1
 3 348
24 GO:0045862 positive regulation of proteolysis 2.797E-4 4.423E-3 3.049E-2
1.547E-1
 3 381
25 GO:0003300 cardiac muscle hypertrophy 3.057E-4 4.423E-3 3.049E-2
1.690E-1
 2 72
26 GO:0014706 striated muscle tissue development 3.157E-4 4.423E-3 3.049E-2
1.746E-1
 3 397
27 GO:0055013 cardiac muscle cell development 3.229E-4 4.423E-3 3.049E-2
1.786E-1
 2 74
28 GO:0060249 anatomical structure homeostasis 3.276E-4 4.423E-3 3.049E-2
1.812E-1
 3 402
29 GO:0014897 striated muscle hypertrophy 3.317E-4 4.423E-3 3.049E-2
1.834E-1
 2 75
30 GO:0014896 muscle hypertrophy 3.496E-4 4.423E-3 3.049E-2
1.933E-1
 2 77
31 GO:0055006 cardiac cell development 3.588E-4 4.423E-3 3.049E-2
1.984E-1
 2 78
32 GO:0060537 muscle tissue development 3.597E-4 4.423E-3 3.049E-2
1.989E-1
 3 415
33 GO:0051394 regulation of nerve growth factor receptor activity 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
34 GO:0001896 autolysis 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
35 GO:1990091 sodium-dependent self proteolysis 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
36 GO:0060299 negative regulation of sarcomere organization 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
37 GO:0097398 cellular response to interleukin-17 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
38 GO:0038009 regulation of signal transduction by receptor internalization 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
39 GO:0097396 response to interleukin-17 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
40 GO:1903886 positive regulation of chemokine (C-C motif) ligand 20 production 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
41 GO:0097400 interleukin-17-mediated signaling pathway 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
42 GO:1903884 regulation of chemokine (C-C motif) ligand 20 production 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
43 GO:1900826 negative regulation of membrane depolarization during cardiac muscle cell action potential 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
44 GO:1903881 regulation of interleukin-17-mediated signaling pathway 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
45 GO:0036392 chemokine (C-C motif) ligand 20 production 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
46 GO:1903883 positive regulation of interleukin-17-mediated signaling pathway 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
47 GO:0007014 actin ubiquitination 3.759E-4 4.423E-3 3.049E-2
2.079E-1
 1 1
48 GO:0003012 muscle system process 3.993E-4 4.600E-3 3.171E-2
2.208E-1
 3 430
49 GO:0051149 positive regulation of muscle cell differentiation 5.318E-4 6.002E-3 4.137E-2
2.941E-1
 2 95
50 GO:1902532 negative regulation of intracellular signal transduction 5.856E-4 6.387E-3 4.403E-2
3.238E-1
 3 490
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 31 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030017 sarcomere 2.375E-9 4.169E-8 1.679E-7 7.361E-8 5 198
2 GO:0044449 contractile fiber part 3.594E-9 4.169E-8 1.679E-7 1.114E-7 5 215
3 GO:0030016 myofibril 4.034E-9 4.169E-8 1.679E-7 1.251E-7 5 220
4 GO:0043292 contractile fiber 5.500E-9 4.263E-8 1.717E-7 1.705E-7 5 234
5 GO:0030018 Z disc 4.982E-8 3.089E-7 1.244E-6 1.544E-6 4 119
6 GO:0031674 I band 8.285E-8 4.281E-7 1.724E-6 2.568E-6 4 135
7 GO:0030315 T-tubule 1.029E-6 4.555E-6 1.834E-5 3.189E-5 3 60
8 GO:0042383 sarcolemma 1.700E-5 6.587E-5 2.653E-4 5.269E-4 3 152
9 GO:0005863 striated muscle myosin thick filament 1.468E-3 5.057E-3 2.037E-2 4.552E-2 1 4
10 GO:0005859 muscle myosin complex 7.323E-3 2.007E-2
8.084E-2
2.270E-1
 1 20
11 GO:0016010 dystrophin-associated glycoprotein complex 8.053E-3 2.007E-2
8.084E-2
2.496E-1
 1 22
12 GO:0090665 glycoprotein complex 8.053E-3 2.007E-2
8.084E-2
2.496E-1
 1 22
13 GO:0032982 myosin filament 8.417E-3 2.007E-2
8.084E-2
2.609E-1
 1 23
14 GO:0016460 myosin II complex 9.875E-3 2.116E-2
8.522E-2
3.061E-1
 1 27
15 GO:0036379 myofilament 1.024E-2 2.116E-2
8.522E-2
3.174E-1
 1 28
16 GO:0005801 cis-Golgi network 1.424E-2 2.758E-2
1.111E-1
4.413E-1
 1 39
17 GO:0014704 intercalated disc 2.111E-2 3.760E-2
1.514E-1
6.544E-1
 1 58
18 GO:0031594 neuromuscular junction 2.183E-2 3.760E-2
1.514E-1
6.768E-1
 1 60
19 GO:0016459 myosin complex 2.471E-2 3.997E-2
1.610E-1
7.660E-1
 1 68
20 GO:0044291 cell-cell contact zone 2.579E-2 3.997E-2
1.610E-1
7.994E-1
 1 71
Show 15 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 425 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003560 Muscular dystrophy 2.029E-10 8.249E-8 5.470E-7 8.621E-8 7 197
2 HP:0003236 Elevated serum creatine phosphokinase 7.313E-10 8.249E-8 5.470E-7 3.108E-7 7 236
3 HP:0040081 Abnormal levels of creatine kinase in blood 7.313E-10 8.249E-8 5.470E-7 3.108E-7 7 236
4 HP:0011021 Abnormality of circulating enzyme level 7.764E-10 8.249E-8 5.470E-7 3.300E-7 7 238
5 HP:0009127 Abnormality of the musculature of the limbs 6.173E-9 5.247E-7 3.479E-6 2.623E-6 7 319
6 HP:0003701 Proximal muscle weakness 4.418E-8 3.129E-6 2.075E-5 1.877E-5 6 206
7 HP:0010876 Abnormality of circulating protein level 5.690E-8 3.455E-6 2.291E-5 2.418E-5 7 437
8 HP:0001430 Abnormality of the calf musculature 6.908E-8 3.670E-6 2.433E-5 2.936E-5 4 33
9 HP:0003391 Gowers sign 3.260E-7 1.539E-5 1.021E-4 1.385E-4 4 48
10 HP:0004303 Abnormality of muscle fibers 1.615E-6 6.862E-5 4.550E-4 6.862E-4 5 182
11 HP:0003457 EMG abnormality 2.163E-6 8.358E-5 5.542E-4 9.194E-4 5 193
12 HP:0008981 Calf muscle hypertrophy 2.649E-6 9.383E-5 6.221E-4 1.126E-3 3 21
13 HP:0008968 Muscle hypertrophy of the lower extremities 3.066E-6 1.002E-4 6.645E-4 1.303E-3 3 22
14 HP:0001437 Abnormality of the musculature of the lower limbs 4.779E-6 1.451E-4 9.619E-4 2.031E-3 4 93
15 HP:0001446 Abnormality of the musculature of the upper limbs 7.199E-6 1.923E-4 1.275E-3 3.060E-3 4 103
16 HP:0003557 Increased variability in muscle fiber diameter 7.241E-6 1.923E-4 1.275E-3 3.078E-3 3 29
17 HP:0003551 Difficulty climbing stairs 8.041E-6 2.010E-4 1.333E-3 3.417E-3 3 30
18 HP:0012084 Abnormality of skeletal muscle fiber size 1.800E-5 4.249E-4 2.817E-3 7.648E-3 3 39
19 HP:0007340 Lower limb muscle weakness 6.002E-5 1.343E-3 8.902E-3 2.551E-2 3 58
20 HP:0001284 Areflexia 1.021E-4 2.138E-3 1.418E-2 4.339E-2 4 201
21 HP:0001435 Abnormality of the shoulder girdle musculature 1.057E-4 2.138E-3 1.418E-2 4.491E-2 3 70
22 HP:0002355 Difficulty walking 1.406E-4 2.704E-3 1.793E-2
5.974E-2
 3 77
23 HP:0003749 Pelvic girdle muscle weakness 1.711E-4 2.704E-3 1.793E-2
7.271E-2
 2 14
24 HP:0003555 Muscle fiber splitting 1.711E-4 2.704E-3 1.793E-2
7.271E-2
 2 14
25 HP:0003738 Exercise-induced myalgia 1.711E-4 2.704E-3 1.793E-2
7.271E-2
 2 14
26 HP:0002981 Abnormality of the calf 1.851E-4 2.704E-3 1.793E-2
7.867E-2
 4 234
27 HP:0003202 Skeletal muscle atrophy 1.965E-4 2.704E-3 1.793E-2
8.351E-2
 5 483
28 HP:0001445 Abnormality of the hip-girdle musculature 1.973E-4 2.704E-3 1.793E-2
8.384E-2
 2 15
29 HP:0009046 Difficulty running 1.973E-4 2.704E-3 1.793E-2
8.384E-2
 2 15
30 HP:0007019 Difficulty walking and climbing stairs 1.973E-4 2.704E-3 1.793E-2
8.384E-2
 2 15
31 HP:0001469 Abnormality of the musculature of the pelvis 1.973E-4 2.704E-3 1.793E-2
8.384E-2
 2 15
32 HP:0004302 Functional motor deficit 3.371E-4 4.478E-3 2.969E-2
1.433E-1
 4 273
33 HP:0003547 Shoulder girdle muscle weakness 3.557E-4 4.581E-3 3.037E-2
1.512E-1
 2 20
34 HP:0003043 Abnormality of the shoulder 4.396E-4 5.495E-3 3.643E-2
1.868E-1
 3 113
35 HP:0002522 Areflexia of lower limbs 5.152E-4 6.256E-3 4.148E-2
2.190E-1
 2 24
36 HP:0003198 Myopathy 5.648E-4 6.668E-3 4.421E-2
2.401E-1
 4 312
37 HP:0007126 Proximal amyotrophy 6.058E-4 6.959E-3 4.614E-2
2.575E-1
 2 26
38 HP:0009025 Increased connective tissue 6.538E-4 7.312E-3 4.849E-2
2.779E-1
 2 27
39 HP:0002460 Distal muscle weakness 1.030E-3 1.123E-2
7.445E-2
4.379E-1
 3 151
40 HP:0000467 Neck muscle weakness 1.440E-3 1.495E-2
9.911E-2
6.118E-1
 2 40
41 HP:0003760 Percussion-induced rapid rolling muscle contractions 1.487E-3 1.495E-2
9.911E-2
6.320E-1
 1 1
42 HP:0003559 Muscle hyperirritability 1.487E-3 1.495E-2
9.911E-2
6.320E-1
 1 1
43 HP:0003797 Limb-girdle muscle atrophy 1.512E-3 1.495E-2
9.911E-2
6.427E-1
 2 41
44 HP:0003805 Rimmed vacuoles 1.663E-3 1.606E-2
1.065E-1
7.068E-1
 2 43
45 HP:0001315 Reduced tendon reflexes 1.758E-3 1.661E-2
1.101E-1
7.473E-1
 4 420
46 HP:0003712 Skeletal muscle hypertrophy 1.919E-3 1.773E-2
1.176E-1
8.155E-1
 3 187
47 HP:0009810 Abnormality of upper limb joint 2.096E-3 1.896E-2
1.257E-1
8.909E-1
 4 440
48 HP:0003690 Limb muscle weakness 2.198E-3 1.946E-2
1.291E-1
9.342E-1
 3 196
49 HP:0003458 EMG: myopathic abnormalities 2.335E-3 2.025E-2
1.343E-1
9.923E-1
 2 51
50 HP:0008994 Proximal muscle weakness in lower limbs 2.615E-3 2.223E-2
1.474E-1
1.000E0
 2 54
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 7 input genes in category / 142 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009404 centrally nucleated skeletal muscle fibers 2.710E-12 3.848E-10 2.130E-9 3.848E-10 6 91
2 MP:0000752 dystrophic muscle 2.027E-11 1.439E-9 7.968E-9 2.878E-9 5 43
3 MP:0009398 abnormal skeletal muscle fiber size 6.789E-11 3.213E-9 1.779E-8 9.640E-9 6 154
4 MP:0003084 abnormal skeletal muscle fiber morphology 6.593E-10 2.340E-8 1.296E-7 9.362E-8 6 224
5 MP:0009403 increased variability of skeletal muscle fiber size 2.116E-8 6.011E-7 3.328E-6 3.005E-6 4 53
6 MP:0004087 abnormal muscle fiber morphology 4.953E-8 1.172E-6 6.490E-6 7.033E-6 6 459
7 MP:0000749 muscle degeneration 6.993E-8 1.253E-6 6.940E-6 9.930E-6 4 71
8 MP:0000759 abnormal skeletal muscle morphology 7.062E-8 1.253E-6 6.940E-6 1.003E-5 6 487
9 MP:0004121 abnormal sarcolemma morphology 2.146E-7 3.386E-6 1.875E-5 3.048E-5 3 20
10 MP:0009414 skeletal muscle fiber necrosis 4.886E-7 6.938E-6 3.841E-5 6.938E-5 3 26
11 MP:0010090 increased circulating creatine kinase level 1.580E-6 2.023E-5 1.120E-4 2.243E-4 3 38
12 MP:0020280 increased creatine kinase level 1.711E-6 2.023E-5 1.120E-4 2.430E-4 3 39
13 MP:0010089 abnormal circulating creatine kinase level 1.995E-6 2.023E-5 1.120E-4 2.832E-4 3 41
14 MP:0009415 skeletal muscle degeneration 1.995E-6 2.023E-5 1.120E-4 2.832E-4 3 41
15 MP:0020279 abnormal creatine kinase level 2.147E-6 2.033E-5 1.126E-4 3.049E-4 3 42
16 MP:0003852 skeletal muscle necrosis 2.476E-6 2.197E-5 1.217E-4 3.516E-4 3 44
17 MP:0009402 decreased skeletal muscle fiber diameter 3.230E-6 2.698E-5 1.494E-4 4.586E-4 3 48
18 MP:0000751 myopathy 4.624E-6 3.648E-5 2.019E-4 6.566E-4 3 54
19 MP:0000750 abnormal muscle regeneration 1.016E-5 7.591E-5 4.203E-4 1.442E-3 3 70
20 MP:0009400 decreased skeletal muscle fiber size 3.250E-5 2.307E-4 1.278E-3 4.615E-3 3 103
21 MP:0004819 decreased skeletal muscle mass 8.667E-5 5.861E-4 3.245E-3 1.231E-2 3 143
22 MP:0004817 abnormal skeletal muscle mass 1.351E-4 8.718E-4 4.827E-3 1.918E-2 3 166
23 MP:0009412 skeletal muscle fiber degeneration 1.468E-4 9.066E-4 5.019E-3 2.085E-2 2 28
24 MP:0004510 myositis 1.805E-4 1.068E-3 5.912E-3 2.563E-2 2 31
25 MP:0009419 skeletal muscle fibrosis 3.330E-4 1.891E-3 1.047E-2 4.728E-2 2 42
26 MP:0004232 decreased muscle weight 3.491E-4 1.907E-3 1.056E-2 4.957E-2 2 43
27 MP:0004233 abnormal muscle weight 5.111E-4 2.688E-3 1.488E-2
7.258E-2
 2 52
28 MP:0009417 skeletal muscle atrophy 7.741E-4 3.926E-3 2.174E-2
1.099E-1
 2 64
29 MP:0011116 absent Reichert's membrane 1.352E-3 6.237E-3 3.453E-2
1.919E-1
 1 2
30 MP:0004150 absent caveolae 1.352E-3 6.237E-3 3.453E-2
1.919E-1
 1 2
31 MP:0004090 abnormal sarcomere morphology 1.362E-3 6.237E-3 3.453E-2
1.933E-1
 2 85
32 MP:0010240 decreased skeletal muscle size 1.525E-3 6.767E-3 3.747E-2
2.165E-1
 2 90
33 MP:0010581 abnormal atrium myocardial trabeculae morphology 2.027E-3 8.641E-3 4.784E-2
2.878E-1
 1 3
34 MP:0009458 abnormal skeletal muscle size 2.069E-3 8.641E-3 4.784E-2
2.938E-1
 2 105
35 MP:0000733 abnormal muscle development 2.148E-3 8.713E-3 4.824E-2
3.050E-1
 2 107
36 MP:0002269 muscular atrophy 2.648E-3 1.010E-2
5.590E-2
3.761E-1
 2 119
37 MP:0000731 increased collagen deposition in the muscles 2.702E-3 1.010E-2
5.590E-2
3.836E-1
 1 4
38 MP:0011201 abnormal visceral yolk sac cavity morphology 2.702E-3 1.010E-2
5.590E-2
3.836E-1
 1 4
39 MP:0000746 weakness 3.748E-3 1.365E-2
7.556E-2
5.323E-1
 2 142
40 MP:0012094 abnormal Reichert's membrane thickness 4.050E-3 1.438E-2
7.960E-2
5.751E-1
 1 6
41 MP:0003358 abnormal hypaxial muscle morphology 4.793E-3 1.660E-2
9.191E-2
6.806E-1
 2 161
42 MP:0005330 cardiomyopathy 5.028E-3 1.700E-2
9.413E-2
7.140E-1
 2 165
43 MP:0000730 increased satellite cell number 6.742E-3 2.227E-2
1.233E-1
9.574E-1
 1 10
44 MP:0030566 abnormal A band morphology 7.415E-3 2.301E-2
1.274E-1
1.000E0
 1 11
45 MP:0009420 skeletal muscle endomysial fibrosis 7.415E-3 2.301E-2
1.274E-1
1.000E0
 1 11
46 MP:0003141 cardiac fibrosis 7.455E-3 2.301E-2
1.274E-1
1.000E0
 2 202
47 MP:0003044 impaired basement membrane formation 8.086E-3 2.343E-2
1.297E-1
1.000E0
 1 12
48 MP:0011191 increased embryonic epiblast cell apoptosis 8.086E-3 2.343E-2
1.297E-1
1.000E0
 1 12
49 MP:0011105 embryonic lethality between implantation and placentation, incomplete penetrance 8.086E-3 2.343E-2
1.297E-1
1.000E0
 1 12
50 MP:0002280 abnormal intercostal muscle morphology 8.758E-3 2.438E-2
1.350E-1
1.000E0
 1 13
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 84 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2.20.160.10 - Gene3D 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
2 IPR009644 Fukutin-related InterPro 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
3 IPR031091 CAV-3 InterPro 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
4 PF09470 Telethonin Pfam 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
5 IPR023111 Titin-like domain InterPro 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
6 IPR015667 Telethonin InterPro 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
7 IPR029531 CAPN3 InterPro 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
8 IPR033569 TRIM32 InterPro 3.736E-4 3.923E-3 1.967E-2 3.139E-2 1 1
9 PF04991 LicD Pfam 7.471E-4 5.537E-3 2.776E-2
6.276E-2
 1 2
10 IPR007074 LicD fam InterPro 7.471E-4 5.537E-3 2.776E-2
6.276E-2
 1 2
11 IPR018361 Caveolin CS InterPro 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
12 IPR012560 Ferlin A-domain InterPro 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
13 IPR001612 Caveolin InterPro 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
14 PF08165 FerA Pfam 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
15 PF01146 Caveolin Pfam 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
16 SM01200 FerA SMART 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
17 PS01210 CAVEOLIN PROSITE 1.121E-3 5.537E-3 2.776E-2
9.413E-2
 1 3
18 IPR006614 Peroxin/Ferlin InterPro 1.494E-3 5.601E-3 2.808E-2
1.255E-1
 1 4
19 SM00693 DysFN SMART 1.494E-3 5.601E-3 2.808E-2
1.255E-1
 1 4
20 SM00694 DysFC SMART 1.494E-3 5.601E-3 2.808E-2
1.255E-1
 1 4
21 IPR012561 Ferlin B-domain InterPro 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
22 IPR032362 Ferlin C InterPro 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
23 PF08150 FerB Pfam 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
24 SM01201 FerB SMART 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
25 IPR012968 FerIin dom InterPro 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
26 SM01202 FerI SMART 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
27 PF08151 FerI Pfam 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
28 PF16165 Ferlin C Pfam 1.867E-3 5.601E-3 2.808E-2
1.568E-1
 1 5
29 IPR013017 NHL repeat subgr InterPro 3.358E-3 9.728E-3 4.877E-2
2.821E-1
 1 9
30 IPR001258 NHL repeat InterPro 3.731E-3 1.011E-2
5.069E-2
3.134E-1
 1 10
31 PF01436 NHL Pfam 3.731E-3 1.011E-2
5.069E-2
3.134E-1
 1 10
32 IPR022683 Calpain III InterPro 4.476E-3 1.072E-2
5.373E-2
3.760E-1
 1 12
33 IPR013805 GrpE coiled coil InterPro 4.476E-3 1.072E-2
5.373E-2
3.760E-1
 1 12
34 IPR033883 C2 III InterPro 4.476E-3 1.072E-2
5.373E-2
3.760E-1
 1 12
35 SM00720 calpain III SMART 4.476E-3 1.072E-2
5.373E-2
3.760E-1
 1 12
36 PF01067 Calpain III Pfam 4.848E-3 1.072E-2
5.373E-2
4.072E-1
 1 13
37 PS51125 NHL PROSITE 4.848E-3 1.072E-2
5.373E-2
4.072E-1
 1 13
38 IPR022682 Calpain domain III InterPro 4.848E-3 1.072E-2
5.373E-2
4.072E-1
 1 13
39 IPR022684 Calpain cysteine protease InterPro 5.220E-3 1.092E-2
5.477E-2
4.385E-1
 1 14
40 PS50203 CALPAIN CAT PROSITE 5.592E-3 1.092E-2
5.477E-2
4.697E-1
 1 15
41 IPR001300 Peptidase C2 calpain cat InterPro 5.592E-3 1.092E-2
5.477E-2
4.697E-1
 1 15
42 PF00648 Peptidase C2 Pfam 5.592E-3 1.092E-2
5.477E-2
4.697E-1
 1 15
43 SM00230 CysPc SMART 5.592E-3 1.092E-2
5.477E-2
4.697E-1
 1 15
44 PF13202 EF-hand 5 Pfam 9.305E-3 1.758E-2
8.815E-2
7.816E-1
 1 25
45 PS00139 THIOL PROTEASE CYS PROSITE 9.676E-3 1.758E-2
8.815E-2
8.128E-1
 1 26
46 PS00639 THIOL PROTEASE HIS PROSITE 1.005E-2 1.758E-2
8.815E-2
8.439E-1
 1 27
47 IPR018253 DnaJ domain CS InterPro 1.005E-2 1.758E-2
8.815E-2
8.439E-1
 1 27
48 PS00640 THIOL PROTEASE ASN PROSITE 1.005E-2 1.758E-2
8.815E-2
8.439E-1
 1 27
49 IPR000169 Pept cys AS InterPro 1.042E-2 1.786E-2
8.953E-2
8.750E-1
 1 28
50 IPR027370 Znf-RING LisH InterPro 1.264E-2 2.041E-2
1.023E-1
1.000E0
 1 34
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 22 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269868 Muscle contraction BioSystems: REACTOME 1.445E-4 1.861E-3 6.868E-3 3.180E-3 3 204
2 1269870 Smooth Muscle Contraction BioSystems: REACTOME 1.692E-4 1.861E-3 6.868E-3 3.722E-3 2 36

8: Pubmed [Display Chart] 7 input genes in category / 933 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20301582 Limb-Girdle Muscular Dystrophy Overview Pubmed 4.946E-24 4.615E-21 3.423E-20 4.615E-21 7 21
2 20405035 Dysferlin interacts with tubulin and microtubules in mouse skeletal muscle. Pubmed 4.521E-10 2.109E-7 1.564E-6 4.218E-7 3 10
3 23414517 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Pubmed 6.872E-10 2.137E-7 1.585E-6 6.412E-7 4 82
4 15827562 Protein studies in dysferlinopathy patients using llama-derived antibody fragments selected by phage display. Pubmed 2.879E-8 3.838E-6 2.846E-5 2.686E-5 2 2
5 14749532 Dysferlin in a hyperCKaemic patient with caveolin 3 mutation and in C2C12 cells after p38 MAP kinase inhibition. Pubmed 2.879E-8 3.838E-6 2.846E-5 2.686E-5 2 2
6 11532985 The sarcolemmal proteins dysferlin and caveolin-3 interact in skeletal muscle. Pubmed 2.879E-8 3.838E-6 2.846E-5 2.686E-5 2 2
7 16319126 Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3. Pubmed 2.879E-8 3.838E-6 2.846E-5 2.686E-5 2 2
8 25198651 Contribution of dysferlin deficiency to skeletal muscle pathology in asymptomatic and severe dystroglycanopathy models: generation of a new model for Fukuyama congenital muscular dystrophy. Pubmed 8.637E-8 8.059E-6 5.976E-5 8.059E-5 2 3
9 18096699 Caveolin regulates endocytosis of the muscle repair protein, dysferlin. Pubmed 8.637E-8 8.059E-6 5.976E-5 8.059E-5 2 3
10 19380584 Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin. Pubmed 8.637E-8 8.059E-6 5.976E-5 8.059E-5 2 3
11 19143834 Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling. Pubmed 2.879E-7 2.238E-5 1.660E-4 2.686E-4 2 5
12 17148677 Simultaneous dystrophin and dysferlin deficiencies associated with high-level expression of the coxsackie and adenovirus receptor in transgenic mice. Pubmed 2.879E-7 2.238E-5 1.660E-4 2.686E-4 2 5
13 26060189 Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies. Pubmed 4.318E-7 3.099E-5 2.298E-4 4.028E-4 2 6
14 20301725 Hypertrophic Cardiomyopathy Overview Pubmed 6.640E-6 3.940E-4 2.922E-3 6.195E-3 2 22
15 20301486 Dilated Cardiomyopathy Overview Pubmed 1.424E-5 3.940E-4 2.922E-3 1.329E-2 2 32
16 12461690 Clinical variability in calpainopathy: what makes the difference? Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
17 23332128 Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
18 21836041 Activation of skeletal muscle calpain-3 by eccentric exercise in humans does not result in its translocation to the nucleus or cytosol. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
19 22560623 Myogenesis in dysferlin-deficient myoblasts is inhibited by an intrinsic inflammatory response. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
20 16175175 TRIM family proteins: retroviral restriction and antiviral defence. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
21 16896923 Identification and characterization of a novel human dysferlin transcript: dysferlin v1. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
22 20082313 Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
23 15535137 In vivo and in vitro dysferlin expression in human muscle satellite cells. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
24 19179078 Four Caucasian patients with mutations in the fukutin gene and variable clinical phenotype. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
25 26112643 Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
26 29206848 Caveolin-3 promotes glycometabolism, growth and proliferation in muscle cells. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
27 15318348 Developmental and tissue-specific regulation of a novel dysferlin isoform. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
28 14678801 Molecular analysis of LGMD-2B and MM patients: identification of novel DYSF mutations and possible founder effect in the Italian population. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
29 14981167 Caveolinopathies: mutations in caveolin-3 cause four distinct autosomal dominant muscle diseases. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
30 20533264 [Different splice of the calpain 3 gene in human skeletal muscle tissue and white blood cells]. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
31 15682833 Caveolae localization and caveolin expressions in Schwann cells of mature rat spinal nerves. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
32 14663034 A CAV3 microdeletion differentially affects skeletal muscle and myocardium. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
33 26371419 A novel mutation in DNAJB6, p.(Phe91Leu), in childhood-onset LGMD1D with a severe phenotype. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
34 14512171 Muscle inflammation and MHC class I up-regulation in muscular dystrophy with lack of dysferlin: an immunopathological study. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
35 16862423 The inflammatory reaction pattern distinguishes primary dysferlinopathies from idiopathic inflammatory myopathies: an important role for the membrane attack complex. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
36 17405141 A novel missense mutation in the caveolin-3 gene in rippling muscle disease. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
37 16797397 Loss of podocyte dysferlin expression is associated with minimal change nephropathy. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
38 23746531 Nanoscale distribution of ryanodine receptors and caveolin-3 in mouse ventricular myocytes: dilation of t-tubules near junctions. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
39 8275093 Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31-33. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
40 23908349 Restriction of calpain3 expression to the skeletal muscle prevents cardiac toxicity and corrects pathology in a murine model of limb-girdle muscular dystrophy. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
41 23414389 Muscle atrophy in Limb Girdle Muscular Dystrophy 2A: a morphometric and molecular study. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
42 24839933 Deletion of TRIM32 protects mice from anxiety- and depression-like behaviors under mild stress. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
43 17868276 A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
44 15351423 Mutations in Czech LGMD2A patients revealed by analysis of calpain3 mRNA and their phenotypic outcome. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
45 16010686 Dysferlin mutations in LGMD2B, Miyoshi myopathy, and atypical dysferlinopathies. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
46 26073173 Dysferlin deficiency confers increased susceptibility to coxsackievirus-induced cardiomyopathy. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
47 16141003 Extensive scanning of the calpain-3 gene broadens the spectrum of LGMD2A phenotypes. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
48 18853459 Analysis of the DYSF mutational spectrum in a large cohort of patients. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
49 22334415 Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
50 25630502 CAV3 gene sequence variations: National Genome Database and clinics. Pubmed 1.833E-4 3.940E-4 2.922E-3
1.710E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 236 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DYSF DYSF interactions 6.238E-9 1.472E-6 8.897E-6 1.472E-6 3 11
2 int:TRIM72 TRIM72 interactions 7.359E-6 6.945E-4 4.197E-3 1.737E-3 2 11
3 int:CAPN3 CAPN3 interactions 8.829E-6 6.945E-4 4.197E-3 2.084E-3 2 12
4 int:CAV3 CAV3 interactions 2.346E-4 1.384E-2
8.366E-2
5.538E-2
 2 60
5 int:TTN TTN interactions 4.070E-4 1.921E-2
1.161E-1
9.605E-2
 2 79
6 int:ALKBH1 ALKBH1 interactions 7.907E-4 3.110E-2
1.879E-1
1.866E-1
 1 2
7 int:TP73 TP73 interactions 1.271E-3 4.284E-2
2.589E-1
2.998E-1
 2 140
8 int:JPH2 JPH2 interactions 1.581E-3 4.414E-2
2.668E-1
3.731E-1
 1 4
9 int:RNF208 RNF208 interactions 1.976E-3 4.414E-2
2.668E-1
4.663E-1
 1 5
10 int:FKTN FKTN interactions 2.370E-3 4.414E-2
2.668E-1
5.594E-1
 1 6
11 int:HCN4 HCN4 interactions 2.370E-3 4.414E-2
2.668E-1
5.594E-1
 1 6
12 int:MSTN MSTN interactions 2.765E-3 4.414E-2
2.668E-1
6.526E-1
 1 7
13 int:SLC22A11 SLC22A11 interactions 2.765E-3 4.414E-2
2.668E-1
6.526E-1
 1 7
14 int:REEP2 REEP2 interactions 2.765E-3 4.414E-2
2.668E-1
6.526E-1
 1 7
15 int:ANKRD1 ANKRD1 interactions 3.160E-3 4.414E-2
2.668E-1
7.457E-1
 1 8
16 int:MYOZ3 MYOZ3 interactions 3.554E-3 4.414E-2
2.668E-1
8.387E-1
 1 9
17 int:ANKRD2 ANKRD2 interactions 3.554E-3 4.414E-2
2.668E-1
8.387E-1
 1 9
18 int:SLC8A1 SLC8A1 interactions 3.554E-3 4.414E-2
2.668E-1
8.387E-1
 1 9
19 int:SCGB1A1 SCGB1A1 interactions 3.554E-3 4.414E-2
2.668E-1
8.387E-1
 1 9
20 int:MYLPF MYLPF interactions 3.948E-3 4.419E-2
2.671E-1
9.318E-1
 1 10
21 int:ATXN1 ATXN1 interactions 4.298E-3 4.419E-2
2.671E-1
1.000E0
 2 260
22 int:RIPOR2 RIPOR2 interactions 4.342E-3 4.419E-2
2.671E-1
1.000E0
 1 11
23 int:ANKRD13C ANKRD13C interactions 4.342E-3 4.419E-2
2.671E-1
1.000E0
 1 11
24 int:CLIP4 CLIP4 interactions 4.736E-3 4.419E-2
2.671E-1
1.000E0
 1 12
25 int:REEP1 REEP1 interactions 4.736E-3 4.419E-2
2.671E-1
1.000E0
 1 12
26 int:CIAO2A CIAO2A interactions 5.130E-3 4.419E-2
2.671E-1
1.000E0
 1 13
27 int:C12orf45 C12orf45 interactions 5.524E-3 4.419E-2
2.671E-1
1.000E0
 1 14
28 int:NDRG2 NDRG2 interactions 5.524E-3 4.419E-2
2.671E-1
1.000E0
 1 14
29 int:RXYLT1 RXYLT1 interactions 5.917E-3 4.419E-2
2.671E-1
1.000E0
 1 15
30 int:STUB1 STUB1 interactions 6.132E-3 4.419E-2
2.671E-1
1.000E0
 2 312
31 int:FTSJ1 FTSJ1 interactions 6.311E-3 4.419E-2
2.671E-1
1.000E0
 1 16
32 int:MYOZ2 MYOZ2 interactions 6.311E-3 4.419E-2
2.671E-1
1.000E0
 1 16
33 int:HDAC6 HDAC6 interactions 6.325E-3 4.419E-2
2.671E-1
1.000E0
 2 317
34 int:ZNF211 ZNF211 interactions 6.704E-3 4.419E-2
2.671E-1
1.000E0
 1 17
35 int:PTCD2 PTCD2 interactions 6.704E-3 4.419E-2
2.671E-1
1.000E0
 1 17
36 int:MYOZ1 MYOZ1 interactions 7.097E-3 4.419E-2
2.671E-1
1.000E0
 1 18
37 int:NGB NGB interactions 7.097E-3 4.419E-2
2.671E-1
1.000E0
 1 18
38 int:SGCA SGCA interactions 7.490E-3 4.419E-2
2.671E-1
1.000E0
 1 19
39 int:CEP95 CEP95 interactions 7.490E-3 4.419E-2
2.671E-1
1.000E0
 1 19
40 int:CENPT CENPT interactions 7.490E-3 4.419E-2
2.671E-1
1.000E0
 1 19
41 int:RELA RELA interactions 8.269E-3 4.447E-2
2.687E-1
1.000E0
 2 364
42 int:HSPA4 HSPA4 interactions 8.269E-3 4.447E-2
2.687E-1
1.000E0
 2 364
43 int:SYT6 SYT6 interactions 8.668E-3 4.447E-2
2.687E-1
1.000E0
 1 22
44 int:ENDOD1 ENDOD1 interactions 8.668E-3 4.447E-2
2.687E-1
1.000E0
 1 22
45 int:TBC1D2B TBC1D2B interactions 8.668E-3 4.447E-2
2.687E-1
1.000E0
 1 22
46 int:SCN5A SCN5A interactions 8.668E-3 4.447E-2
2.687E-1
1.000E0
 1 22
47 int:CFAP410 CFAP410 interactions 9.453E-3 4.553E-2
2.751E-1
1.000E0
 1 24
48 int:NFATC3 NFATC3 interactions 9.453E-3 4.553E-2
2.751E-1
1.000E0
 1 24
49 int:TCAP TCAP interactions 9.453E-3 4.553E-2
2.751E-1
1.000E0
 1 24
50 int:MIS18BP1 MIS18BP1 interactions 9.845E-3 4.646E-2
2.808E-1
1.000E0
 1 25
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9q31-q33 9q31-q33 4.039E-4 2.827E-3 7.330E-3 2.827E-3 1 2
2 9q33.1 9q33.1 1.816E-3 6.357E-3 1.648E-2 1.271E-2 1 9
3 3p25 3p25 3.429E-3 8.000E-3 2.074E-2 2.400E-2 1 17
4 7q36.3 7q36.3 6.244E-3 1.043E-2 2.704E-2 4.371E-2 1 31
5 2p13.3 2p13.3 7.449E-3 1.043E-2 2.704E-2
5.214E-2
 1 37
6 15q15.1 15q15.1 1.026E-2 1.196E-2 3.102E-2
7.179E-2
 1 51
7 17q12 17q12 2.102E-2 2.102E-2
5.449E-2
1.471E-1
 1 105
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 22 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 828 Ferlin family genenames.org 1.319E-3 9.230E-3 2.393E-2 9.230E-3 1 6
2 975 EF-hand domain containing|Calpains genenames.org 3.294E-3 1.076E-2 2.789E-2 2.306E-2 1 15
3 980 Bardet-Biedl syndrome associated genenames.org 4.609E-3 1.076E-2 2.789E-2 3.227E-2 1 21
4 584 DNAJ (HSP40) heat shock proteins genenames.org 1.073E-2 1.878E-2 4.869E-2
7.511E-2
 1 49
5 59 Ring finger proteins|Tripartite motif containing genenames.org 2.094E-2 2.932E-2
7.602E-2
1.466E-1
 1 96

13: Coexpression [Display Chart] 7 input genes in category / 617 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 6.246E-6 3.854E-3 2.699E-2 3.854E-3 4 483
2 15955831-Table5 Human StemCell Komor05 56genes GeneSigDB 1.073E-4 3.311E-2
2.319E-1
6.622E-2
 2 53

14: Coexpression Atlas [Display Chart] 7 input genes in category / 271 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Pcdh11x BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Pcdh11x BrainMap 1.349E-5 3.655E-3 2.259E-2 3.655E-3 3 161
2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Sfrp2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Sfrp2 BrainMap 5.218E-5 7.071E-3 4.371E-2 1.414E-2 2 35
3 skeletal muscle skeletal muscle Human Protein Atlas 1.046E-4 9.446E-3
5.839E-2
 2.834E-2 3 320

15: Computational [Display Chart] 5 input genes in category / 10 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 189 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6872-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.606E-5 1.248E-2
7.268E-2
 1.248E-2 2 129
2 TTTTGAG,MIR-373:MSigDB TTTTGAG,MIR-373:MSigDB MSigDB 1.783E-4 1.685E-2
9.807E-2
 3.369E-2 2 212
3 hsa-miR-519b-3p:Functional MTI Functional MTI miRTarbase 4.674E-4 1.828E-2
1.064E-1
8.833E-2
 2 344
4 hsa-miR-519a-3p:Functional MTI Functional MTI miRTarbase 4.810E-4 1.828E-2
1.064E-1
9.090E-2
 2 349
5 hsa-miR-519c-3p:Functional MTI Functional MTI miRTarbase 4.837E-4 1.828E-2
1.064E-1
9.142E-2
 2 350
6 hsa-miR-597:mirSVR highEffct hsa-miR-597:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.050E-4 2.851E-2
1.660E-1
1.710E-1
 2 480
7 hsa-miR-6869-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.453E-3 3.050E-2
1.776E-1
2.745E-1
 1 15
8 AGCGCTT,MIR-518A:MSigDB AGCGCTT,MIR-518A:MSigDB MSigDB 1.646E-3 3.050E-2
1.776E-1
3.111E-1
 1 17
9 AGCGCTT,MIR-518F:MSigDB AGCGCTT,MIR-518F:MSigDB MSigDB 1.646E-3 3.050E-2
1.776E-1
3.111E-1
 1 17
10 AGCGCTT,MIR-518E:MSigDB AGCGCTT,MIR-518E:MSigDB MSigDB 1.646E-3 3.050E-2
1.776E-1
3.111E-1
 1 17
11 hsa-miR-3648:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.936E-3 3.050E-2
1.776E-1
3.660E-1
 1 20
12 hsa-miR-3186-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.936E-3 3.050E-2
1.776E-1
3.660E-1
 1 20
13 hsa-miR-4694-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 3.721E-2
2.166E-1
6.401E-1
 1 35
14 hsa-miR-4999-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.580E-3 3.721E-2
2.166E-1
6.766E-1
 1 37
15 CTCTATG,MIR-368:MSigDB CTCTATG,MIR-368:MSigDB MSigDB 3.676E-3 3.721E-2
2.166E-1
6.949E-1
 1 38
16 hsa-miR-625-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.773E-3 3.721E-2
2.166E-1
7.131E-1
 1 39
17 hsa-miR-7978:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.721E-2
2.166E-1
7.314E-1
 1 40
18 hsa-miR-133a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.159E-3 3.721E-2
2.166E-1
7.861E-1
 1 43
19 hsa-miR-3137:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 3.721E-2
2.166E-1
1.000E0
 1 55
20 hsa-miR-5581-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 3.721E-2
2.166E-1
1.000E0
 1 56
21 hsa-miR-5689:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.721E-2
2.166E-1
1.000E0
 1 58
22 CAAGGAT,MIR-362:MSigDB CAAGGAT,MIR-362:MSigDB MSigDB 5.607E-3 3.721E-2
2.166E-1
1.000E0
 1 58
23 hsa-miR-3152-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 3.721E-2
2.166E-1
1.000E0
 1 66
24 hsa-miR-6813-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.721E-2
2.166E-1
1.000E0
 1 68
25 hsa-miR-4280:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 3.721E-2
2.166E-1
1.000E0
 1 70
26 CTCAAGA,MIR-526B:MSigDB CTCAAGA,MIR-526B:MSigDB MSigDB 6.956E-3 3.721E-2
2.166E-1
1.000E0
 1 72
27 hsa-miR-3177-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 3.721E-2
2.166E-1
1.000E0
 1 75
28 CTCCAAG,MIR-432:MSigDB CTCCAAG,MIR-432:MSigDB MSigDB 7.341E-3 3.721E-2
2.166E-1
1.000E0
 1 76
29 TCTATGA,MIR-376A:MSigDB TCTATGA,MIR-376A:MSigDB MSigDB 7.726E-3 3.721E-2
2.166E-1
1.000E0
 1 80
30 TCTATGA,MIR-376B:MSigDB TCTATGA,MIR-376B:MSigDB MSigDB 7.726E-3 3.721E-2
2.166E-1
1.000E0
 1 80
31 hsa-miR-369-5p:mirSVR highEffct hsa-miR-369-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.823E-3 3.721E-2
2.166E-1
1.000E0
 1 81
32 TCTGGAC,MIR-198:MSigDB TCTGGAC,MIR-198:MSigDB MSigDB 7.823E-3 3.721E-2
2.166E-1
1.000E0
 1 81
33 hsa-miR-1295b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 3.721E-2
2.166E-1
1.000E0
 1 84
34 hsa-miR-3686:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 3.721E-2
2.166E-1
1.000E0
 1 84
35 GGCCAGT,MIR-193A:MSigDB GGCCAGT,MIR-193A:MSigDB MSigDB 8.304E-3 3.721E-2
2.166E-1
1.000E0
 1 86
36 GGCCAGT,MIR-193B:MSigDB GGCCAGT,MIR-193B:MSigDB MSigDB 8.304E-3 3.721E-2
2.166E-1
1.000E0
 1 86
37 hsa-miR-1914-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.400E-3 3.721E-2
2.166E-1
1.000E0
 1 87
38 hsa-miR-2115-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.977E-3 3.721E-2
2.166E-1
1.000E0
 1 93
39 hsa-miR-516b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.977E-3 3.721E-2
2.166E-1
1.000E0
 1 93
40 hsa-miR-7162-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.977E-3 3.721E-2
2.166E-1
1.000E0
 1 93
41 hsa-miR-432-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.073E-3 3.721E-2
2.166E-1
1.000E0
 1 94
42 hsa-miR-20b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.169E-3 3.721E-2
2.166E-1
1.000E0
 1 95
43 hsa-miR-516a-3p:Functional MTI Functional MTI miRTarbase 9.169E-3 3.721E-2
2.166E-1
1.000E0
 1 95
44 hsa-miR-6728-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.362E-3 3.721E-2
2.166E-1
1.000E0
 1 97
45 hsa-miR-3591-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.458E-3 3.721E-2
2.166E-1
1.000E0
 1 98
46 hsa-miR-4724-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.458E-3 3.721E-2
2.166E-1
1.000E0
 1 98
47 hsa-let-7c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.746E-3 3.721E-2
2.166E-1
1.000E0
 1 101
48 ATGCAGT,MIR-217:MSigDB ATGCAGT,MIR-217:MSigDB MSigDB 1.003E-2 3.721E-2
2.166E-1
1.000E0
 1 104
49 hsa-miR-8062:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.032E-2 3.721E-2
2.166E-1
1.000E0
 1 107
50 hsa-miR-4743-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.042E-2 3.721E-2
2.166E-1
1.000E0
 1 108
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1737 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000008202 methyl 9-octadecenoate Stitch 5.398E-11 6.379E-8 5.127E-7 9.376E-8 5 112
2 CID000008330 TCNB Stitch 7.345E-11 6.379E-8 5.127E-7 1.276E-7 5 119
3 CID005326976 CK2 inhibitor 2 Stitch 1.253E-7 7.255E-5 5.831E-4 2.176E-4 3 36
4 CID000027919 N'-nitrosonornicotine Stitch 6.944E-7 3.015E-4 2.424E-3 1.206E-3 3 63
5 255 DN dexamethasone; Down 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Down 2.156E-5 6.433E-3
5.170E-2
 3.745E-2 3 197
6 258 DN LY294002; Down 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Down 2.222E-5 6.433E-3
5.170E-2
 3.860E-2 3 199
7 CID000017699 propinox Stitch 9.403E-5 2.128E-2
1.710E-1
1.633E-1
 2 49
8 CID000508110 AC1LA6KT Stitch 1.019E-4 2.128E-2
1.710E-1
1.770E-1
 2 51
9 CID000003476 glimepiride Stitch 1.143E-4 2.128E-2
1.710E-1
1.986E-1
 2 54
10 CID000234384 alph a- Stitch 1.870E-4 2.128E-2
1.710E-1
3.249E-1
 2 69
11 CID000023912 dysprosium Stitch 2.152E-4 2.128E-2
1.710E-1
3.738E-1
 2 74
12 CID000105145 gallium Stitch 2.515E-4 2.128E-2
1.710E-1
4.369E-1
 2 80
13 CID006433122 pruvanserin Stitch 3.065E-4 2.128E-2
1.710E-1
5.323E-1
 1 1
14 CID000084258 marsiline Stitch 3.065E-4 2.128E-2
1.710E-1
5.323E-1
 1 1
15 CID000152932 O2 2-4 Stitch 3.065E-4 2.128E-2
1.710E-1
5.323E-1
 1 1
16 CID000004688 pargyline Stitch 3.697E-4 2.128E-2
1.710E-1
6.421E-1
 2 97
17 CID005319015 Glc-ceramide Stitch 4.413E-4 2.128E-2
1.710E-1
7.665E-1
 2 106
18 CID000004004 malathion Stitch 5.557E-4 2.128E-2
1.710E-1
9.652E-1
 2 119
19 CID003082267 BrAcUrd Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
20 CID011509704 kengaquinone Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
21 CID005317657 aloeresin A Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
22 CID000075244 1-naphthylamide Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
23 CID000906143 3H-pyrrolo[3,2-f]quinoline Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
24 CID010130877 (5aS,9aS)-6,6,9a-trimethyl-5,5a,7,8,9,9b-hexahydro-1H-benz[e]isobenzofuran-3-one Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
25 CID003032671 thiophthalimide Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
26 CID000636820 kenganthranols A Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
27 CID000619164 AC1LDIKR Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
28 CID012444581 ugandensolide Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
29 CID000420771 4-piperidinemethanol Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
30 CID000156015 4-methylbenzene-1,2,3-triol Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
31 CID000161192 pereniporin B Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
32 CID005317357 flavocommelin Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
33 CID000071984 Iotasul Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
34 CID000191043 histidine hydantoin Stitch 6.129E-4 2.128E-2
1.710E-1
1.000E0
 1 2
35 CID005356750 Evans blue dye Stitch 6.325E-4 2.128E-2
1.710E-1
1.000E0
 2 127
36 CID000002160 amitriptyline Stitch 7.677E-4 2.128E-2
1.710E-1
1.000E0
 2 140
37 CID000125363 Amphb Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
38 CID000076631 2C-H Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
39 CID000125391 7-deoxy-6-epi-castanospermine Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
40 CID000636783 callyspongynic acid Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
41 CID005489114 AC1NUR2V Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
42 CID000073572 Pradimicin Q Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
43 CID003083273 IPG7F Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
44 CID000133001 MP-3022 Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
45 CID000099615 betulinaldehyde Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
46 CID000017370 6-fluoro-N,N-diethyltryptamine Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
47 CID000133488 3-nitro-4-(6-aminohexylamido)phenylboronic acid Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
48 CID000151939 glucono-delta-lactam Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
49 CID005326320 AC1NS0BS Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
50 CID005488919 3,3'-di-O-methylellagic acid Stitch 9.192E-4 2.128E-2
1.710E-1
1.000E0
 1 3
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 388 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1864711 Muscle biopsy shows dystrophic changes DisGeNET Curated 2.645E-19 1.026E-16 6.711E-16 1.026E-16 7 39
2 C0686353 Muscular Dystrophies, Limb-Girdle DisGeNET Curated 3.095E-17 6.004E-15 3.926E-14 1.201E-14 7 74
3 C0241005 Creatine phosphokinase serum increased DisGeNET Curated 8.529E-16 8.273E-14 5.410E-13 3.309E-13 7 117
4 C0151576 Elevated creatine kinase DisGeNET Curated 8.529E-16 8.273E-14 5.410E-13 3.309E-13 7 117
5 C0026850 Muscular Dystrophy DisGeNET Curated 2.344E-14 1.819E-12 1.190E-11 9.096E-12 7 186
6 C0026848 Myopathy DisGeNET Curated 4.124E-12 2.667E-10 1.744E-9 1.600E-9 7 386
7 C0234182 Gowers sign DisGeNET Curated 1.291E-10 6.261E-9 4.095E-8 5.009E-8 4 24
8 C0575071 Gowers sign present DisGeNET Curated 1.291E-10 6.261E-9 4.095E-8 5.009E-8 4 24
9 C1850889 MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2B DisGeNET Curated 2.761E-9 1.190E-7 7.785E-7 1.071E-6 3 8
10 C1843057 Calf muscle hypertrophy DisGeNET Curated 4.141E-9 1.607E-7 1.051E-6 1.607E-6 3 9
11 C0239067 Difficulty walking up stairs DisGeNET Curated 1.084E-8 3.824E-7 2.501E-6 4.206E-6 3 12
12 C1843700 Variation in muscle fiber size DisGeNET Curated 2.757E-8 8.915E-7 5.830E-6 1.070E-5 3 16
13 C0476403 Electromyogram abnormal DisGeNET Curated 1.588E-6 4.740E-5 3.099E-4 6.161E-4 3 59
14 C1853698 Rippling muscle disease DisGeNET Curated 2.397E-6 6.644E-5 4.345E-4 9.301E-4 2 6
15 C1836057 Muscle fiber splitting DisGeNET Curated 3.355E-6 7.233E-5 4.730E-4 1.302E-3 2 7
16 C0427064 Pelvic girdle weakness DisGeNET Curated 3.355E-6 7.233E-5 4.730E-4 1.302E-3 2 7
17 C1866021 Increased connective tissue DisGeNET Curated 3.355E-6 7.233E-5 4.730E-4 1.302E-3 2 7
18 C0560346 Difficulty running DisGeNET Curated 3.355E-6 7.233E-5 4.730E-4 1.302E-3 2 7
19 C0033626 Protein Deficiency DisGeNET Curated 4.308E-6 8.668E-5 5.669E-4 1.671E-3 3 82
20 C1853562 Adult onset DisGeNET Curated 4.468E-6 8.668E-5 5.669E-4 1.734E-3 3 83
21 C1854494 Slow progression DisGeNET Curated 5.706E-6 1.054E-4 6.894E-4 2.214E-3 3 90
22 C0027868 Neuromuscular Diseases DisGeNET Curated 6.932E-6 1.162E-4 7.597E-4 2.689E-3 3 96
23 C0748691 Shoulder weakness DisGeNET Curated 7.186E-6 1.162E-4 7.597E-4 2.788E-3 2 10
24 C0427063 Shoulder girdle weakness DisGeNET Curated 7.186E-6 1.162E-4 7.597E-4 2.788E-3 2 10
25 C2931687 Dysferlinopathy DisGeNET BeFree 1.053E-5 1.542E-4 1.008E-3 4.088E-3 2 12
26 C1850808 Miyoshi myopathy DisGeNET Curated 1.053E-5 1.542E-4 1.008E-3 4.088E-3 2 12
27 C0030552 Paresis DisGeNET Curated 1.073E-5 1.542E-4 1.008E-3 4.164E-3 3 111
28 C1850830 Exercise-induced myalgia DisGeNET Curated 1.452E-5 2.012E-4 1.316E-3 5.634E-3 2 14
29 C0878544 Cardiomyopathies DisGeNET Curated 1.651E-5 2.031E-4 1.328E-3 6.405E-3 4 433
30 C1869123 Limb-girdle muscular dystrophy type 2A DisGeNET Curated 1.675E-5 2.031E-4 1.328E-3 6.499E-3 2 15
31 C2931230 Vacuolar myopathy DisGeNET BeFree 1.675E-5 2.031E-4 1.328E-3 6.499E-3 2 15
32 C1853932 Rimmed vacuoles on biopsy DisGeNET Curated 1.675E-5 2.031E-4 1.328E-3 6.499E-3 2 15
33 C2265792 Skeletal muscle hypertrophy DisGeNET Curated 1.914E-5 2.250E-4 1.472E-3 7.426E-3 2 16
34 C0410174 Fukuyama Type Congenital Muscular Dystrophy DisGeNET Curated 2.169E-5 2.475E-4 1.618E-3 8.414E-3 2 17
35 C0751336 Distal Muscular Dystrophies DisGeNET Curated 3.346E-5 3.709E-4 2.426E-3 1.298E-2 2 21
36 C4021726 EMG: myopathic abnormalities DisGeNET Curated 3.680E-5 3.966E-4 2.593E-3 1.428E-2 2 22
37 C0424448 Mask-like facies DisGeNET Curated 4.776E-5 5.008E-4 3.275E-3 1.853E-2 2 25
38 C0234958 muscle degeneration DisGeNET Curated 5.197E-5 5.253E-4 3.435E-3 2.017E-2 3 188
39 C0013264 Muscular Dystrophy, Duchenne DisGeNET Curated 5.280E-5 5.253E-4 3.435E-3 2.049E-2 3 189
40 cv:C0007193 Primary dilated cardiomyopathy Clinical Variations 5.585E-5 5.418E-4 3.543E-3 2.167E-2 2 27
41 C0311394 Difficulty walking DisGeNET Curated 6.014E-5 5.691E-4 3.722E-3 2.333E-2 2 28
42 C0018798 Congenital Heart Defects DisGeNET Curated 7.858E-5 7.259E-4 4.747E-3 3.049E-2 3 216
43 C1836296 Weakness of lower limb DisGeNET Curated 8.392E-5 7.400E-4 4.839E-3 3.256E-2 2 33
44 C0917713 Becker Muscular Dystrophy DisGeNET Curated 8.392E-5 7.400E-4 4.839E-3 3.256E-2 2 33
45 C0231712 Waddling gait DisGeNET Curated 9.452E-5 8.150E-4 5.330E-3 3.668E-2 2 35
46 C0270960 Congenital myopathy (disorder) DisGeNET BeFree 1.001E-4 8.440E-4 5.519E-3 3.882E-2 2 36
47 C3715165 LEFT VENTRICULAR NONCOMPACTION 10 DisGeNET Curated 1.238E-4 1.001E-3 6.544E-3 4.803E-2 2 40
48 C3809288 LEFT VENTRICULAR NONCOMPACTION 8 DisGeNET Curated 1.238E-4 1.001E-3 6.544E-3 4.803E-2 2 40
49 C0007194 Hypertrophic Cardiomyopathy DisGeNET Curated 1.301E-4 1.030E-3 6.738E-3
5.049E-2
 3 256
50 C0151786 Muscle Weakness DisGeNET Curated 1.697E-4 1.317E-3 8.610E-3
6.583E-2
 3 280
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