Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc242_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 27 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001849 complement component C1q binding 1.034E-9 2.791E-8 1.086E-7 2.791E-8 3 8
2 GO:0046790 virion binding 3.044E-9 4.110E-8 1.599E-7 8.220E-8 3 11
3 GO:0001846 opsonin binding 6.714E-9 6.042E-8 2.351E-7 1.813E-7 3 14
4 GO:0001848 complement binding 2.451E-8 1.654E-7 6.438E-7 6.618E-7 3 21
5 GO:0030246 carbohydrate binding 7.103E-5 3.835E-4 1.493E-3 1.918E-3 3 289
6 GO:0001872 (1->3)-beta-D-glucan binding 3.215E-4 1.240E-3 4.826E-3 8.681E-3 1 1
7 GO:0008029 pentraxin receptor activity 3.215E-4 1.240E-3 4.826E-3 8.681E-3 1 1
8 GO:0001847 opsonin receptor activity 1.286E-3 4.339E-3 1.688E-2 3.471E-2 1 4
9 GO:0070891 lipoteichoic acid binding 1.607E-3 4.820E-3 1.876E-2 4.338E-2 1 5
10 GO:0033265 choline binding 2.249E-3 6.072E-3 2.363E-2
6.072E-2
1 7
11 GO:0030169 low-density lipoprotein particle binding 5.134E-3 1.244E-2 4.842E-2
1.386E-1
1 16
12 GO:0050750 low-density lipoprotein particle receptor binding 5.774E-3 1.244E-2 4.842E-2
1.559E-1
1 18
13 GO:0030247 polysaccharide binding 7.054E-3 1.244E-2 4.842E-2
1.904E-1
1 22
14 GO:0001871 pattern binding 7.054E-3 1.244E-2 4.842E-2
1.904E-1
1 22
15 GO:0070325 lipoprotein particle receptor binding 7.373E-3 1.244E-2 4.842E-2
1.991E-1
1 23
16 GO:0001530 lipopolysaccharide binding 7.373E-3 1.244E-2 4.842E-2
1.991E-1
1 23
17 GO:0071813 lipoprotein particle binding 8.332E-3 1.250E-2 4.863E-2
2.250E-1
1 26
18 GO:0071814 protein-lipid complex binding 8.332E-3 1.250E-2 4.863E-2
2.250E-1
1 26
19 GO:0015485 cholesterol binding 1.375E-2 1.954E-2
7.603E-2
3.712E-1
1 43
20 GO:0032934 sterol binding 1.534E-2 2.070E-2
8.057E-2
4.141E-1
1 48
21 GO:0050997 quaternary ammonium group binding 1.724E-2 2.217E-2
8.625E-2
4.655E-1
1 54
22 GO:0070405 ammonium ion binding 2.514E-2 3.085E-2
1.200E-1
6.787E-1
1 79
23 GO:0005496 steroid binding 3.267E-2 3.675E-2
1.430E-1
8.820E-1
1 103
24 GO:0051082 unfolded protein binding 3.267E-2 3.675E-2
1.430E-1
8.820E-1
1 103
25 GO:0043178 alcohol binding 3.548E-2 3.832E-2
1.491E-1
9.579E-1
1 112
26 GO:0019903 protein phosphatase binding 4.480E-2 4.653E-2
1.811E-1
1.000E0
1 142
Show 21 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 280 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008228 opsonization 3.063E-9 8.577E-7 5.329E-6 8.577E-7 3 11
2 GO:0044867 modulation by host of viral catalytic activity 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
3 GO:0044866 modulation by host of viral exo-alpha-sialidase activity 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
4 GO:0052403 negative regulation by host of symbiont catalytic activity 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
5 GO:1903016 negative regulation of exo-alpha-sialidase activity 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
6 GO:0044871 negative regulation by host of viral glycoprotein metabolic process 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
7 GO:0044868 modulation by host of viral molecular function 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
8 GO:1903015 regulation of exo-alpha-sialidase activity 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
9 GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
10 GO:0044870 modulation by host of viral glycoprotein metabolic process 8.651E-8 2.422E-6 1.505E-5 2.422E-5 2 2
11 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction 2.595E-7 6.605E-6 4.104E-5 7.265E-5 2 3
12 GO:0006953 acute-phase response 5.118E-7 9.686E-6 6.019E-5 1.433E-4 3 56
13 GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction 5.189E-7 9.686E-6 6.019E-5 1.453E-4 2 4
14 GO:0052422 modulation by host of symbiont catalytic activity 5.189E-7 9.686E-6 6.019E-5 1.453E-4 2 4
15 GO:0052405 negative regulation by host of symbiont molecular function 5.189E-7 9.686E-6 6.019E-5 1.453E-4 2 4
16 GO:0052055 modulation by symbiont of host molecular function 8.647E-7 1.424E-5 8.850E-5 2.421E-4 2 5
17 GO:0052428 modulation by host of symbiont molecular function 8.647E-7 1.424E-5 8.850E-5 2.421E-4 2 5
18 GO:0052204 negative regulation of molecular function in other organism involved in symbiotic interaction 1.297E-6 1.729E-5 1.074E-4 3.631E-4 2 6
19 GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction 1.297E-6 1.729E-5 1.074E-4 3.631E-4 2 6
20 GO:0044359 modulation of molecular function in other organism 1.297E-6 1.729E-5 1.074E-4 3.631E-4 2 6
21 GO:0044362 negative regulation of molecular function in other organism 1.297E-6 1.729E-5 1.074E-4 3.631E-4 2 6
22 GO:0044793 negative regulation by host of viral process 3.888E-6 4.949E-5 3.075E-4 1.089E-3 2 10
23 GO:1903019 negative regulation of glycoprotein metabolic process 1.036E-5 1.261E-4 7.837E-4 2.901E-3 2 16
24 GO:0002526 acute inflammatory response 1.199E-5 1.398E-4 8.690E-4 3.356E-3 3 159
25 GO:0043901 negative regulation of multi-organism process 1.364E-5 1.528E-4 9.493E-4 3.819E-3 3 166
26 GO:0044788 modulation by host of viral process 1.639E-5 1.765E-4 1.097E-3 4.590E-3 2 20
27 GO:0046597 negative regulation of viral entry into host cell 2.182E-5 2.263E-4 1.406E-3 6.110E-3 2 23
28 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 3.168E-5 3.168E-4 1.969E-3 8.872E-3 3 220
29 GO:0046596 regulation of viral entry into host cell 4.272E-5 4.125E-4 2.563E-3 1.196E-2 2 32
30 GO:0006909 phagocytosis 4.922E-5 4.594E-4 2.855E-3 1.378E-2 3 255
31 GO:1903018 regulation of glycoprotein metabolic process 8.134E-5 7.347E-4 4.565E-3 2.278E-2 2 44
32 GO:0045429 positive regulation of nitric oxide biosynthetic process 1.052E-4 8.930E-4 5.549E-3 2.947E-2 2 50
33 GO:1904407 positive regulation of nitric oxide metabolic process 1.052E-4 8.930E-4 5.549E-3 2.947E-2 2 50
34 GO:0044003 modification by symbiont of host morphology or physiology 1.095E-4 9.020E-4 5.605E-3 3.067E-2 2 51
35 GO:0051851 modification by host of symbiont morphology or physiology 1.322E-4 1.058E-3 6.571E-3 3.701E-2 2 56
36 GO:0051702 interaction with symbiont 1.468E-4 1.082E-3 6.722E-3 4.111E-2 2 59
37 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 1.468E-4 1.082E-3 6.722E-3 4.111E-2 2 59
38 GO:0050766 positive regulation of phagocytosis 1.468E-4 1.082E-3 6.722E-3 4.111E-2 2 59
39 GO:0032677 regulation of interleukin-8 production 1.622E-4 1.164E-3 7.235E-3 4.541E-2 2 62
40 GO:0045428 regulation of nitric oxide biosynthetic process 1.729E-4 1.210E-3 7.519E-3 4.840E-2 2 64
41 GO:0032637 interleukin-8 production 1.952E-4 1.333E-3 8.284E-3
5.466E-2
2 68
42 GO:0006809 nitric oxide biosynthetic process 2.376E-4 1.584E-3 9.841E-3
6.652E-2
2 75
43 GO:0046209 nitric oxide metabolic process 2.636E-4 1.716E-3 1.067E-2
7.381E-2
2 79
44 GO:2001057 reactive nitrogen species metabolic process 2.910E-4 1.811E-3 1.125E-2
8.147E-2
2 83
45 GO:1903426 regulation of reactive oxygen species biosynthetic process 2.910E-4 1.811E-3 1.125E-2
8.147E-2
2 83
46 GO:0050764 regulation of phagocytosis 3.124E-4 1.902E-3 1.182E-2
8.747E-2
2 86
47 GO:0050830 defense response to Gram-positive bacterium 3.498E-4 2.084E-3 1.295E-2
9.793E-2
2 91
48 GO:1903901 negative regulation of viral life cycle 3.575E-4 2.085E-3 1.296E-2
1.001E-1
2 92
49 GO:0048525 negative regulation of viral process 3.811E-4 2.178E-3 1.353E-2
1.067E-1
2 95
50 GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 3.892E-4 2.179E-3 1.354E-2
1.090E-1
2 96
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 106 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002412 increased susceptibility to bacterial infection 3.027E-4 3.208E-2
1.683E-1
3.208E-2 3 262
2 MP:0020186 altered susceptibility to bacterial infection 6.351E-4 3.366E-2
1.766E-1
6.732E-2
3 337

6: Domain [Display Chart] 6 input genes in category / 21 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00289 PENTAXIN PROSITE 3.932E-17 7.568E-16 2.759E-15 8.257E-16 5 9
2 SM00159 PTX SMART 7.863E-17 7.568E-16 2.759E-15 1.651E-15 5 10
3 PF00354 Pentaxin Pfam 1.442E-16 7.568E-16 2.759E-15 3.027E-15 5 11
4 IPR001759 Pentaxin-related InterPro 1.442E-16 7.568E-16 2.759E-15 3.027E-15 5 11
5 IPR030476 Pentaxin CS InterPro 1.461E-14 6.138E-14 2.237E-13 3.069E-13 4 5
6 2.60.120.200 - Gene3D 1.801E-11 6.304E-11 2.298E-10 3.782E-10 5 95
7 IPR013320 ConA-like dom InterPro 1.239E-9 3.718E-9 1.355E-8 2.603E-8 5 219
8 IPR030180 LBP InterPro 3.203E-4 8.407E-4 3.065E-3 6.725E-3 1 1
9 SM00560 LamGL SMART 1.281E-3 2.689E-3 9.803E-3 2.689E-2 1 4
10 IPR006558 LamG-like InterPro 1.281E-3 2.689E-3 9.803E-3 2.689E-2 1 4
11 IPR030675 BPI/LBP InterPro 1.600E-3 2.801E-3 1.021E-2 3.361E-2 1 5
12 IPR017954 Lipid-bd serum glycop CS InterPro 1.600E-3 2.801E-3 1.021E-2 3.361E-2 1 5
13 SM00329 BPI2 SMART 2.879E-3 4.031E-3 1.469E-2
6.046E-2
1 9
14 PS00400 LBP BPI CETP PROSITE 2.879E-3 4.031E-3 1.469E-2
6.046E-2
1 9
15 SM00328 BPI1 SMART 2.879E-3 4.031E-3 1.469E-2
6.046E-2
1 9
16 PF02886 LBP BPI CETP C Pfam 3.199E-3 4.157E-3 1.515E-2
6.717E-2
1 10
17 IPR001124 Lipid-bd serum glycop C InterPro 3.837E-3 4.157E-3 1.515E-2
8.059E-2
1 12
18 PF01273 LBP BPI CETP Pfam 4.157E-3 4.157E-3 1.515E-2
8.729E-2
1 13
19 IPR017943 Bactericidal perm-incr a/b dom InterPro 4.157E-3 4.157E-3 1.515E-2
8.729E-2
1 13
20 IPR017942 Lipid-bd serum glycop N InterPro 4.157E-3 4.157E-3 1.515E-2
8.729E-2
1 13
21 IPR032942 BPI/LBP/Plunc InterPro 4.157E-3 4.157E-3 1.515E-2
8.729E-2
1 13
Show 16 more annotations

7: Pathway [Display Chart] 4 input genes in category / 20 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 6.961E-5 1.392E-3 5.009E-3 1.392E-3 2 43
2 1269235 Transfer of LPS from LBP carrier to CD14 BioSystems: REACTOME 6.425E-4 4.283E-3 1.541E-2 1.285E-2 1 2
3 PW:0000503 classical complement Pathway Ontology 6.425E-4 4.283E-3 1.541E-2 1.285E-2 1 2
4 1269246 Classical antibody-mediated complement activation BioSystems: REACTOME 4.811E-3 2.053E-2
7.384E-2
9.622E-2
1 15
5 1427857 Regulation of TLR by endogenous ligand BioSystems: REACTOME 5.131E-3 2.053E-2
7.384E-2
1.026E-1
1 16
6 1269243 Creation of C4 and C2 activators BioSystems: REACTOME 6.731E-3 2.162E-2
7.778E-2
1.346E-1
1 21
7 M2701 Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. MSigDB C2 BIOCARTA (v6.0) 8.648E-3 2.162E-2
7.778E-2
1.730E-1
1 27
8 M11106 Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages MSigDB C2 BIOCARTA (v6.0) 8.648E-3 2.162E-2
7.778E-2
1.730E-1
1 27
9 1269242 Initial triggering of complement BioSystems: REACTOME 9.924E-3 2.205E-2
7.934E-2
1.985E-1
1 31
10 M19043 Adrenergic Pathway MSigDB C2 BIOCARTA (v6.0) 1.152E-2 2.304E-2
8.287E-2
2.304E-1
1 36
11 1269241 Complement cascade BioSystems: REACTOME 1.724E-2 3.134E-2
1.128E-1
3.448E-1
1 54
12 375172 Salmonella infection BioSystems: KEGG 2.735E-2 4.400E-2
1.583E-1
5.470E-1
1 86
13 634527 NF-kappa B signaling pathway BioSystems: KEGG 3.018E-2 4.400E-2
1.583E-1
6.036E-1
1 95
14 1269169 Amyloid fiber formation BioSystems: REACTOME 3.237E-2 4.400E-2
1.583E-1
6.475E-1
1 102
15 83076 Toll-like receptor signaling pathway BioSystems: KEGG 3.300E-2 4.400E-2
1.583E-1
6.600E-1
1 104
16 1470923 Interleukin-4 and 13 signaling BioSystems: REACTOME 3.613E-2 4.516E-2
1.625E-1
7.226E-1
1 114
17 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 3.988E-2 4.691E-2
1.688E-1
7.975E-1
1 126
Show 12 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 2734 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23527487 The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. Pubmed 2.154E-12 5.889E-9 5.001E-8 5.889E-9 3 3
2 23544079 Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. Pubmed 8.616E-12 7.852E-9 6.667E-8 2.356E-8 3 4
3 16380821 Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunity. Pubmed 8.616E-12 7.852E-9 6.667E-8 2.356E-8 3 4
4 19011614 Structural recognition and functional activation of FcgammaR by innate pentraxins. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
5 21173097 Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
6 8144569 Specificity of the binding interaction between human serum amyloid P-component and immobilized human C-reactive protein. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
7 1979065 The mouse C-reactive protein gene maps to distal chromosome 1 and, like its human counterpart, is closely linked to the serum amyloid P component gene. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
8 3759147 The human C-reactive protein gene (CRP) and serum amyloid P component gene (APCS) are located on the proximal long arm of chromosome 1. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
9 20640440 Pentraxin3 and high-sensitive C-reactive protein are independent inflammatory markers released during high-intensity exercise. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
10 21901123 Lipopolysaccharide-binding protein for monitoring of postoperative sepsis: complemental to C-reactive protein or redundant? Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
11 25754824 Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
12 25854969 Associations between pentraxin 3 and severity of coronary artery disease. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
13 17138933 Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health Study. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
14 22867744 Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
15 16643876 Competitive binding of pentraxins and IgM to newly exposed epitopes on late apoptotic cells. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
16 8977214 Acute phase proteins in salmonids: evolutionary analyses and acute phase response. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
17 18650775 Pentraxin 3 and C-reactive protein in severe meningococcal disease. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
18 24568622 Pentraxin 3 and C-reactive protein as inflammatory markers after a kidney transplant. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
19 20930309 Evaluation of intrathecal serum amyloid P (SAP) and C-reactive protein (CRP) synthesis in Alzheimer's disease with the use of index values. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
20 21360619 Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
21 1477104 Human serum amyloid P-component (SAP) selectively binds to immobilized or bound forms of C-reactive protein (CRP). Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
22 24347428 Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome. Pubmed 2.057E-8 2.556E-6 2.170E-5 5.623E-5 2 2
23 26046926 Sepsis biomarkers in neutropaenic systemic inflammatory response syndrome patients on standard care wards. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
24 29374201 C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
25 21106539 Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
26 25491620 The levels of serum pentraxin3, CRP, fetuin-A, and insulin in patients with psoriasis. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
27 27986928 Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
28 16763034 Neuronal pentraxins mediate synaptic refinement in the developing visual system. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
29 17610819 Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
30 9261167 Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
31 17676666 Targeted protein quantitation and profiling using PVDF affinity probe and MALDI-TOF MS. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
32 2477488 Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
33 24709882 Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
34 12432394 Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
35 25344970 [Diagnostic importance of pentraxins at the early phase of acute pancreatitis]. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
36 16115696 Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
37 28228104 Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera. Pubmed 6.170E-8 4.559E-6 3.871E-5 1.687E-4 2 3
38 25613713 Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection. Pubmed 1.234E-7 8.433E-6 7.161E-5 3.373E-4 2 4
39 10748068 Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. Pubmed 1.234E-7 8.433E-6 7.161E-5 3.373E-4 2 4
40 9030885 Serum amyloid A gene expression in rabbit, mink and mouse. Pubmed 1.234E-7 8.433E-6 7.161E-5 3.373E-4 2 4
41 26106150 DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice. Pubmed 2.056E-7 1.371E-5 1.164E-4 5.622E-4 2 5
42 23182717 Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells: enrolment of PI3K/Akt and AP-1. Pubmed 3.084E-7 2.008E-5 1.705E-4 8.432E-4 2 6
43 10652269 An essential role in liver development for transcription factor XBP-1. Pubmed 5.756E-7 3.577E-5 3.037E-4 1.574E-3 2 8
44 2591369 A 6000 kb segment of chromosome 1 is conserved in human and mouse. Pubmed 5.756E-7 3.577E-5 3.037E-4 1.574E-3 2 8
45 7797269 Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1. Pubmed 7.400E-7 4.398E-5 3.735E-4 2.023E-3 2 9
46 1693656 Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3. Pubmed 7.400E-7 4.398E-5 3.735E-4 2.023E-3 2 9
47 14718574 The human plasma proteome: a nonredundant list developed by combination of four separate sources. Pubmed 1.597E-6 9.291E-5 7.889E-4 4.367E-3 3 166
48 18799149 The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Pubmed 2.794E-6 1.591E-4 1.351E-3 7.639E-3 2 17
49 1301170 Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA. Pubmed 3.143E-6 1.754E-4 1.489E-3 8.593E-3 2 18
50 22939635 Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Pubmed 3.513E-6 1.921E-4 1.631E-3 9.604E-3 2 19
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 99 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CYB5D2 CYB5D2 interactions 1.209E-8 1.197E-6 6.199E-6 1.197E-6 3 16
2 int:C1QA C1QA interactions 1.176E-7 5.820E-6 3.013E-5 1.164E-5 3 33
3 int:NPTX2 NPTX2 interactions 9.569E-7 3.158E-5 1.635E-4 9.473E-5 2 5
4 int:NPTXR NPTXR interactions 1.435E-6 3.552E-5 1.839E-4 1.421E-4 2 6
5 int:C4BPA C4BPA interactions 1.146E-5 2.270E-4 1.175E-3 1.135E-3 2 16
6 int:APCS APCS interactions 1.633E-5 2.309E-4 1.196E-3 1.616E-3 2 19
7 int:FCGR2B FCGR2B interactions 1.633E-5 2.309E-4 1.196E-3 1.616E-3 2 19
8 int:CFH CFH interactions 2.205E-5 2.728E-4 1.413E-3 2.183E-3 2 22
9 int:FCGR1A FCGR1A interactions 2.633E-5 2.897E-4 1.500E-3 2.607E-3 2 24
10 int:LAMA1 LAMA1 interactions 9.416E-5 9.322E-4 4.826E-3 9.322E-3 2 45
11 int:CRP CRP interactions 1.462E-4 1.316E-3 6.814E-3 1.448E-2 2 56
12 int:BST1 BST1 interactions 1.016E-3 8.386E-3 4.342E-2
1.006E-1
1 3
13 int:CFHR1 CFHR1 interactions 2.032E-3 1.490E-2
7.713E-2
2.012E-1
1 6
14 int:CHST3 CHST3 interactions 2.370E-3 1.490E-2
7.713E-2
2.347E-1
1 7
15 int:CA11 CA11 interactions 2.370E-3 1.490E-2
7.713E-2
2.347E-1
1 7
16 int:C1GALT1 C1GALT1 interactions 2.709E-3 1.490E-2
7.713E-2
2.682E-1
1 8
17 int:CAMP CAMP interactions 2.709E-3 1.490E-2
7.713E-2
2.682E-1
1 8
18 int:C1QC C1QC interactions 2.709E-3 1.490E-2
7.713E-2
2.682E-1
1 8
19 int:TG TG interactions 3.385E-3 1.675E-2
8.674E-2
3.351E-1
1 10
20 int:LEP LEP interactions 3.385E-3 1.675E-2
8.674E-2
3.351E-1
1 10
21 int:NXPE3 NXPE3 interactions 3.723E-3 1.675E-2
8.674E-2
3.686E-1
1 11
22 int:HS6ST1 HS6ST1 interactions 3.723E-3 1.675E-2
8.674E-2
3.686E-1
1 11
23 int:ZNF224 ZNF224 interactions 4.061E-3 1.742E-2
9.018E-2
4.020E-1
1 12
24 int:PTX3 PTX3 interactions 4.399E-3 1.742E-2
9.018E-2
4.355E-1
1 13
25 int:GP6 GP6 interactions 4.399E-3 1.742E-2
9.018E-2
4.355E-1
1 13
26 int:HIST1H2AL HIST1H2AL interactions 5.074E-3 1.860E-2
9.632E-2
5.023E-1
1 15
27 int:COLEC10 COLEC10 interactions 5.074E-3 1.860E-2
9.632E-2
5.023E-1
1 15
28 int:NDST2 NDST2 interactions 5.411E-3 1.870E-2
9.683E-2
5.357E-1
1 16
29 int:STC2 STC2 interactions 5.749E-3 1.870E-2
9.683E-2
5.691E-1
1 17
30 int:QSOX1 QSOX1 interactions 5.749E-3 1.870E-2
9.683E-2
5.691E-1
1 17
31 int:CEMIP2 CEMIP2 interactions 6.086E-3 1.870E-2
9.683E-2
6.025E-1
1 18
32 int:GMPPA GMPPA interactions 6.423E-3 1.870E-2
9.683E-2
6.359E-1
1 19
33 int:LBP LBP interactions 6.423E-3 1.870E-2
9.683E-2
6.359E-1
1 19
34 int:GDF11 GDF11 interactions 6.423E-3 1.870E-2
9.683E-2
6.359E-1
1 19
35 int:FCGR3A FCGR3A interactions 7.097E-3 1.887E-2
9.771E-2
7.026E-1
1 21
36 int:B4GALT5 B4GALT5 interactions 7.434E-3 1.887E-2
9.771E-2
7.360E-1
1 22
37 int:FCGR3B FCGR3B interactions 7.434E-3 1.887E-2
9.771E-2
7.360E-1
1 22
38 int:ST3GAL4 ST3GAL4 interactions 7.434E-3 1.887E-2
9.771E-2
7.360E-1
1 22
39 int:LAMC3 LAMC3 interactions 7.434E-3 1.887E-2
9.771E-2
7.360E-1
1 22
40 int:CHST12 CHST12 interactions 7.771E-3 1.923E-2
9.958E-2
7.693E-1
1 23
41 int:IMPAD1 IMPAD1 interactions 8.108E-3 1.944E-2
1.007E-1
8.027E-1
1 24
42 int:AGRN AGRN interactions 8.444E-3 1.944E-2
1.007E-1
8.360E-1
1 25
43 int:EXT1 EXT1 interactions 8.444E-3 1.944E-2
1.007E-1
8.360E-1
1 25
44 int:C1QB C1QB interactions 8.781E-3 1.950E-2
1.010E-1
8.693E-1
1 26
45 int:B4GALT7 B4GALT7 interactions 9.117E-3 1.950E-2
1.010E-1
9.026E-1
1 27
46 int:TIMP3 TIMP3 interactions 9.454E-3 1.950E-2
1.010E-1
9.359E-1
1 28
47 int:SPTB SPTB interactions 9.454E-3 1.950E-2
1.010E-1
9.359E-1
1 28
48 int:PYCR3 PYCR3 interactions 9.454E-3 1.950E-2
1.010E-1
9.359E-1
1 28
49 int:SFTPC SFTPC interactions 9.790E-3 1.966E-2
1.018E-1
9.692E-1
1 29
50 int:GOT2 GOT2 interactions 1.013E-2 1.966E-2
1.018E-1
1.000E0
1 30
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q21-q23 1q21-q23 2.270E-6 1.135E-5 2.592E-5 1.135E-5 2 14
2 7q21.3-q22.1 7q21.3-q22.1 1.038E-3 2.596E-3 5.927E-3 5.191E-3 1 6
3 3q25 3q25 2.248E-3 3.747E-3 8.556E-3 1.124E-2 1 13
4 20q11.23 20q11.23 6.560E-3 8.201E-3 1.872E-2 3.280E-2 1 38
5 22q13.1 22q13.1 1.531E-2 1.531E-2 3.496E-2
7.654E-2
1 89

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 29 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1142 Long pentraxins genenames.org 1.992E-10 5.977E-10 1.096E-9 5.977E-10 3 5
2 1143 Short pentraxins genenames.org 2.719E-7 4.078E-7 7.476E-7 8.156E-7 2 3
3 456 BPI fold containing genenames.org 5.266E-3 5.266E-3 9.654E-3 1.580E-2 1 16

13: Coexpression [Display Chart] 6 input genes in category / 594 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16138077-Table3 Mouse Liver Gresh05 62genes GeneSigDB 3.717E-5 1.007E-2
7.011E-2
2.208E-2 2 37
2 19061838-TableS13 Mouse Viral Cairo08 620genes GeneSigDB 5.470E-5 1.007E-2
7.011E-2
3.249E-2 3 328
3 16455954-Table2 Human StemCell Dekker06 107genes GeneSigDB 7.972E-5 1.007E-2
7.011E-2
4.735E-2 2 54
4 M7054 Genes up-regulated specifically in human liver tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.272E-5 1.007E-2
7.011E-2
4.913E-2 2 55
5 16455954-TableS2 Human StemCell Dekker06 439genes GeneSigDB 8.474E-5 1.007E-2
7.011E-2
5.033E-2
3 380
6 M18168 Genes up-regulated in MEF cells (embryonic fibroblast) isolated from NRAS [GeneID=4893] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.267E-4 1.254E-2
8.736E-2
7.526E-2
2 68
7 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 1.582E-4 1.271E-2
8.851E-2
9.394E-2
3 469
8 16909116-Table2 Mouse StemCell Castellano07 104genes GeneSigDB 1.711E-4 1.271E-2
8.851E-2
1.017E-1
2 79
9 M14228 Cluster a: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.743E-4 1.810E-2
1.261E-1
1.629E-1
2 100
10 15988020-Table1 Human StemCell Osada05 129genes GeneSigDB 4.282E-4 2.500E-2
1.742E-1
2.544E-1
2 125
11 17304354-Table2s Human Lymphoma Piccaluga07 185genes GeneSigDB 4.630E-4 2.500E-2
1.742E-1
2.750E-1
2 130
12 M2398 Genes down-regulated in liver tissue upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.741E-4 3.119E-2
2.173E-1
4.004E-1
2 157
13 M5941 Genes up-regulated in response to ultraviolet (UV) radiation. MSigDB H: Hallmark Gene Sets (v6.0) 6.827E-4 3.119E-2
2.173E-1
4.055E-1
2 158
14 M8212 Genes up-regulated in germinal center B lymphocytes: control versus over-expressing PRDM1 [GeneID=639]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.408E-2
2.374E-1
6.475E-1
2 200
15 M5026 Genes down-regulated in comparison of SP1 thymocytes versus SP3 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.408E-2
2.374E-1
6.475E-1
2 200
16 M3273 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) cultured for 12 h versus PBMC cultured for 12 h with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.408E-2
2.374E-1
6.475E-1
2 200
17 M8851 Genes down-regulated in multipotent progenitors versus RAG2 [GeneID=5897] knockout NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.408E-2
2.374E-1
6.475E-1
2 200
18 M7268 Genes up-regulated in double positive thymocytes: wildtype versus TCF3 [GeneID=6929] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.408E-2
2.374E-1
6.475E-1
2 200
19 M3440 Genes down-regulated in comparison of intrathymic T progenitor cells (ITTP) versus CD4 [GeneID=920] thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.408E-2
2.374E-1
6.475E-1
2 200
20 M6175 Genes down-regulated at early fetal liver stage (embryonic days E11.5 - E12.5) compared to the late fetal liver stage (embryonic days E14.5 - E16.5). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.340E-3 3.981E-2
2.773E-1
7.961E-1
2 222
21 M13148 Genes down-regulated 6 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.555E-3 4.362E-2
3.038E-1
9.237E-1
1 6
22 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 1.616E-3 4.362E-2
3.038E-1
9.597E-1
2 244
23 M13867 Genes up-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.776E-3 4.490E-2
3.127E-1
1.000E0
2 256
24 17012836-Table4 Human pancreas Rogers06 10genes X3P-arrays GeneSigDB 1.814E-3 4.490E-2
3.127E-1
1.000E0
1 7
Show 19 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 578 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 liver liver Human Protein Atlas 1.345E-4 4.963E-2
3.443E-1
7.775E-2
3 419
2 gudmap developingKidney e15.5 Ureteral Smooth Musc 100 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.225E-4 4.963E-2
3.443E-1
1.286E-1
2 85
3 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/5/0 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/5/0 TCGA-Liver 5.358E-4 4.963E-2
3.443E-1
3.097E-1
2 132
4 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium 7.470E-4 4.963E-2
3.443E-1
4.318E-1
2 156
5 adipose tissue adipose tissue Human Protein Atlas 7.953E-4 4.963E-2
3.443E-1
4.597E-1
2 161
6 gudmap developingKidney e15.5 Ureteral Smooth Musc 200 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.250E-4 4.963E-2
3.443E-1
4.769E-1
2 164
7 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium 8.350E-4 4.963E-2
3.443E-1
4.827E-1
2 165
8 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup4/Calb1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup4/Calb1 BrainMap 8.860E-4 4.963E-2
3.443E-1
5.121E-1
2 170
9 Sample Type by Project: Shred 1/TCGA-Cervix/Endocervical Adenocarcinoma/Endometrioid Adenocarcinoma/1 Sample Type by Project: Shred 1/TCGA-Cervix/Endocervical Adenocarcinoma/Endometrioid Adenocarcinoma/1 TCGA-Cervix 9.385E-4 4.963E-2
3.443E-1
5.425E-1
2 175
10 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/FrontalCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/FrontalCortex BrainMap 1.048E-3 4.963E-2
3.443E-1
6.057E-1
2 185
11 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg7 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg7 BrainMap 1.093E-3 4.963E-2
3.443E-1
6.319E-1
2 189
12 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/mixed excitatory BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/mixed excitatory BrainMap 1.105E-3 4.963E-2
3.443E-1
6.385E-1
2 190
13 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/Rorb/subGroup2//Gja1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/Rorb/subGroup2//Gja1 BrainMap 1.116E-3 4.963E-2
3.443E-1
6.452E-1
2 191
Show 8 more annotations

15: Computational [Display Chart] 6 input genes in category / 62 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 193 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6871-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.433E-5 5.142E-3 3.004E-2 6.625E-3 2 110
2 hsa-miR-7156-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.329E-5 5.142E-3 3.004E-2 1.028E-2 2 137
3 hsa-miR-9500:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.170E-4 7.526E-3 4.397E-2 2.258E-2 2 203
4 hsa-miR-6853-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.821E-3 3.036E-2
1.774E-1
5.444E-1
1 34
5 hsa-miR-1225-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.986E-3 3.036E-2
1.774E-1
5.764E-1
1 36
6 hsa-miR-6821-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.152E-3 3.036E-2
1.774E-1
6.083E-1
1 38
7 hsa-miR-6874-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 3.036E-2
1.774E-1
7.682E-1
1 48
8 hsa-miR-4684-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 3.036E-2
1.774E-1
8.321E-1
1 52
9 hsa-miR-148b-5p:Functional MTI Functional MTI miRTarbase 4.311E-3 3.036E-2
1.774E-1
8.321E-1
1 52
10 hsa-miR-3137:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 3.036E-2
1.774E-1
8.800E-1
1 55
11 hsa-miR-135b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 3.036E-2
1.774E-1
8.800E-1
1 55
12 hsa-miR-584-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.036E-2
1.774E-1
8.960E-1
1 56
13 hsa-miR-4708-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.036E-2
1.774E-1
1.000E0
1 64
14 hsa-miR-4277:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.036E-2
1.774E-1
1.000E0
1 64
15 hsa-miR-3614-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.469E-3 3.036E-2
1.774E-1
1.000E0
1 66
16 hsa-miR-6886-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.469E-3 3.036E-2
1.774E-1
1.000E0
1 66
17 hsa-miR-129-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 3.036E-2
1.774E-1
1.000E0
1 67
18 hsa-miR-501-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.036E-2
1.774E-1
1.000E0
1 69
19 hsa-miR-6774-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.036E-2
1.774E-1
1.000E0
1 69
20 hsa-miR-129-2-3p:Functional MTI Functional MTI miRTarbase 5.883E-3 3.036E-2
1.774E-1
1.000E0
1 71
21 hsa-miR-6822-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.036E-2
1.774E-1
1.000E0
1 72
22 hsa-miR-6750-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.036E-2
1.774E-1
1.000E0
1 72
23 hsa-miR-1247:mirSVR highEffct hsa-miR-1247:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.048E-3 3.036E-2
1.774E-1
1.000E0
1 73
24 hsa-miR-502-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 3.036E-2
1.774E-1
1.000E0
1 74
25 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 3.036E-2
1.774E-1
1.000E0
1 77
26 hsa-miR-191:PITA hsa-miR-191:PITA TOP PITA 6.378E-3 3.036E-2
1.774E-1
1.000E0
1 77
27 hsa-miR-6856-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 3.036E-2
1.774E-1
1.000E0
1 77
28 hsa-miR-4660:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.626E-3 3.036E-2
1.774E-1
1.000E0
1 80
29 hsa-miR-3686:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.036E-2
1.774E-1
1.000E0
1 84
30 hsa-miR-3151-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 3.036E-2
1.774E-1
1.000E0
1 85
31 hsa-miR-1199-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 3.036E-2
1.774E-1
1.000E0
1 85
32 hsa-miR-6751-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.204E-3 3.036E-2
1.774E-1
1.000E0
1 87
33 hsa-miR-6090:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.287E-3 3.036E-2
1.774E-1
1.000E0
1 88
34 AGGTGCA,MIR-500:MSigDB AGGTGCA,MIR-500:MSigDB MSigDB 7.369E-3 3.036E-2
1.774E-1
1.000E0
1 89
35 hsa-miR-5047:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.369E-3 3.036E-2
1.774E-1
1.000E0
1 89
36 hsa-miR-920:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 3.036E-2
1.774E-1
1.000E0
1 91
37 hsa-miR-5591-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 3.036E-2
1.774E-1
1.000E0
1 91
38 hsa-miR-6726-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 3.036E-2
1.774E-1
1.000E0
1 91
39 hsa-miR-4300:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.617E-3 3.036E-2
1.774E-1
1.000E0
1 92
40 hsa-miR-20b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 3.036E-2
1.774E-1
1.000E0
1 95
41 hsa-miR-4433b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.030E-3 3.036E-2
1.774E-1
1.000E0
1 97
42 hsa-miR-1825:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.195E-3 3.036E-2
1.774E-1
1.000E0
1 99
43 hsa-miR-1296-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.195E-3 3.036E-2
1.774E-1
1.000E0
1 99
44 hsa-miR-4303:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.277E-3 3.036E-2
1.774E-1
1.000E0
1 100
45 hsa-miR-4418:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 3.036E-2
1.774E-1
1.000E0
1 101
46 hsa-miR-576-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.360E-3 3.036E-2
1.774E-1
1.000E0
1 101
47 hsa-miR-6809-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.442E-3 3.036E-2
1.774E-1
1.000E0
1 102
48 hsa-miR-509-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.036E-2
1.774E-1
1.000E0
1 103
49 hsa-miR-6827-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.607E-3 3.036E-2
1.774E-1
1.000E0
1 104
50 hsa-miR-6743-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.607E-3 3.036E-2
1.774E-1
1.000E0
1 104
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1553 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011954225 D00992 Stitch 1.033E-16 1.604E-13 1.271E-12 1.604E-13 6 52
2 CID000004159 medrol Stitch 2.690E-13 2.089E-10 1.655E-9 4.177E-10 6 186
3 CID000003339 fenofibrate Stitch 2.949E-12 1.527E-9 1.210E-8 4.580E-9 6 276
4 CID000003672 ibuprofen Stitch 4.323E-12 1.678E-9 1.330E-8 6.714E-9 6 294
5 CID000002250 AC1L1D9C Stitch 1.241E-11 3.854E-9 3.054E-8 1.927E-8 6 350
6 CID000134577 bisAuTM Stitch 5.592E-10 1.447E-7 1.147E-6 8.684E-7 4 58
7 CID000005508 tolmetin Stitch 1.780E-8 3.949E-6 3.130E-5 2.765E-5 3 23
8 CID000026098 azapropazone Stitch 3.291E-8 6.389E-6 5.064E-5 5.111E-5 3 28
9 CID000003637 hydralazine Stitch 6.306E-8 1.088E-5 8.624E-5 9.793E-5 4 186
10 CID000001014 phosphorylcholine Stitch 8.611E-8 1.337E-5 1.060E-4 1.337E-4 4 201
11 CID000004889 AC1L1J6H Stitch 1.640E-7 2.315E-5 1.835E-4 2.547E-4 4 236
12 CID000003825 ketoprofen Stitch 4.171E-7 5.398E-5 4.278E-4 6.478E-4 3 64
13 CID000124815 MObetaDG Stitch 8.622E-7 1.018E-4 8.072E-4 1.339E-3 2 6
14 CID000004781 phenylbutazone Stitch 9.181E-7 1.018E-4 8.072E-4 1.426E-3 3 83
15 CID000001015 phosphoethanolamine Stitch 1.096E-6 1.135E-4 8.993E-4 1.702E-3 3 88
16 CID000124238 SM-8849 Stitch 1.207E-6 1.171E-4 9.284E-4 1.874E-3 2 7
17 CID000066826 nitarsone Stitch 1.609E-6 1.470E-4 1.165E-3 2.499E-3 2 8
18 CID000131272 FPCA Stitch 2.069E-6 1.785E-4 1.414E-3 3.212E-3 2 9
19 CID004475485 AC1NAE4O Stitch 2.459E-6 2.010E-4 1.593E-3 3.819E-3 3 115
20 CID000150311 ezetimibe Stitch 5.150E-6 3.999E-4 3.169E-3 7.998E-3 3 147
21 CID000004087 LEVICOR Stitch 1.090E-5 7.730E-4 6.126E-3 1.693E-2 2 20
22 CID000003016 diazepam Stitch 1.095E-5 7.730E-4 6.126E-3 1.701E-2 3 189
23 6060 UP 3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.221E-5 8.245E-4 6.535E-3 1.896E-2 3 196
24 CID006483663 CA-11 Stitch 1.721E-5 1.113E-3 8.824E-3 2.672E-2 2 25
25 CID000001473 AC1L1BK6 Stitch 4.694E-5 2.916E-3 2.311E-2
7.290E-2
2 41
26 CID000004829 pioglitazone Stitch 5.581E-5 3.258E-3 2.582E-2
8.667E-2
3 326
27 CID000445811 AC1L9IM3 Stitch 5.665E-5 3.258E-3 2.582E-2
8.797E-2
2 45
28 CID000001699 AC1L1C1F Stitch 6.726E-5 3.730E-3 2.956E-2
1.044E-1
2 49
29 ctd:D010400 Penicillin G CTD 9.119E-5 4.731E-3 3.750E-2
1.416E-1
2 57
30 ctd:D017258 Medroxyprogesterone Acetate CTD 9.437E-5 4.731E-3 3.750E-2
1.466E-1
3 389
31 CID000013006 1,2-cyclohexanedione Stitch 9.444E-5 4.731E-3 3.750E-2
1.467E-1
2 58
32 CID006011258 chrysamine Stitch 1.151E-4 5.416E-3 4.293E-2
1.787E-1
2 64
33 ctd:D004917 Erythromycin CTD 1.151E-4 5.416E-3 4.293E-2
1.787E-1
2 64
34 CID009600420 {[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)ethanoyl]amino}methylphosphonic Acid Stitch 1.187E-4 5.423E-3 4.298E-2
1.844E-1
2 65
35 ctd:C418118 CI 1044 CTD 1.712E-4 7.595E-3
6.019E-2
2.658E-1
2 78
36 DB03945 Phosphocholine Drug Bank 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
37 ctd:C047637 nomegestrol CTD 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
38 DB01651 Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside Drug Bank 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
39 ctd:C038501 nomegestrol acetate CTD 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
40 ctd:D005578 Fosfomycin CTD 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
41 DB07579 BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE Drug Bank 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
42 CID000032353 iron sorbitol citric-acid complex Stitch 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
43 DB07580 BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Drug Bank 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
44 CID004369594 2a3x Stitch 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
45 CID016076177 Hs106 Stitch 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
46 ctd:C008958 polyestradiol phosphate CTD 2.627E-4 8.868E-3
7.029E-2
4.080E-1
1 1
47 CID000011313 Congo red Stitch 4.050E-4 1.338E-2
1.061E-1
6.289E-1
2 120
48 CID000040846 Muramyl dipeptide Stitch 4.254E-4 1.376E-2
1.091E-1
6.607E-1
2 123
49 CID004369452 T2 D Stitch 4.534E-4 1.437E-2
1.139E-1
7.042E-1
2 127
50 CID000131554 DMEQ-TAD Stitch 5.253E-4 1.568E-2
1.242E-1
8.158E-1
1 2
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 424 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0004623 Bacterial Infections DisGeNET Curated 9.184E-7 3.894E-4 2.581E-3 3.894E-4 4 258
2 C0344315 Depressed mood DisGeNET Curated 1.550E-5 3.263E-3 2.163E-2 6.572E-3 2 17
3 C0276653 Invasive Pulmonary Aspergillosis DisGeNET BeFree 3.142E-5 3.263E-3 2.163E-2 1.332E-2 2 24
4 C3536715 AA amyloidosis DisGeNET BeFree 3.698E-5 3.263E-3 2.163E-2 1.568E-2 2 26
5 C0221014 Reactive systemic amyloidosis DisGeNET Curated 4.300E-5 3.263E-3 2.163E-2 1.823E-2 2 28
6 C0242172 Pelvic Inflammatory Disease DisGeNET BeFree 4.618E-5 3.263E-3 2.163E-2 1.958E-2 2 29
7 C0497406 Overweight DisGeNET Curated 6.056E-5 3.668E-3 2.431E-2 2.568E-2 3 238
8 C0038587 Substance Withdrawal Syndrome DisGeNET Curated 1.807E-4 7.981E-3
5.290E-2
7.662E-2
2 57
9 C0152031 Joint swelling DisGeNET Curated 1.871E-4 7.981E-3
5.290E-2
7.934E-2
2 58
10 C0002965 Angina, Unstable DisGeNET Curated 2.003E-4 7.981E-3
5.290E-2
8.493E-2
2 60
11 C0311375 Arsenic Poisoning DisGeNET Curated 2.071E-4 7.981E-3
5.290E-2
8.779E-2
2 61
12 C0026269 Mitral Valve Stenosis DisGeNET Curated 2.499E-4 8.830E-3
5.853E-2
1.060E-1
2 67
13 C0042029 Urinary tract infection DisGeNET Curated 2.887E-4 8.987E-3
5.957E-2
1.224E-1
2 72
14 C0262655 Recurrent urinary tract infection DisGeNET Curated 2.968E-4 8.987E-3
5.957E-2
1.258E-1
2 73
15 C3829514 Intrapartum Pyrexia DisGeNET BeFree 3.703E-4 9.235E-3
6.121E-2
1.570E-1
1 1
16 C0744421 Immune-complex glomerulonephritis DisGeNET BeFree 3.703E-4 9.235E-3
6.121E-2
1.570E-1
1 1
17 C1442907 Foreign body giant cell granuloma DisGeNET BeFree 3.703E-4 9.235E-3
6.121E-2
1.570E-1
1 1
18 C0036690 Septicemia DisGeNET Curated 3.997E-4 9.405E-3
6.234E-2
1.695E-1
3 450
19 C0004610 Bacteremia DisGeNET Curated 4.215E-4 9.405E-3
6.234E-2
1.787E-1
2 87
20 C0243026 Sepsis DisGeNET Curated 5.384E-4 1.141E-2
7.565E-2
2.283E-1
3 498
21 C0919746 Engraftment syndrome DisGeNET BeFree 7.404E-4 1.365E-2
9.047E-2
3.139E-1
1 2
22 C0857812 Sickle cell-beta^+^-thalassemia DisGeNET Curated 7.404E-4 1.365E-2
9.047E-2
3.139E-1
1 2
23 C1865794 RHYNS syndrome DisGeNET BeFree 7.404E-4 1.365E-2
9.047E-2
3.139E-1
1 2
24 C0026691 Mucocutaneous Lymph Node Syndrome DisGeNET Curated 8.677E-4 1.495E-2
9.909E-2
3.679E-1
2 125
25 C0042384 Vasculitis DisGeNET Curated 8.815E-4 1.495E-2
9.909E-2
3.738E-1
2 126
26 C0023827 liposarcoma DisGeNET Curated 9.380E-4 1.518E-2
1.006E-1
3.977E-1
2 130
27 C0040028 Thrombocythemia, Essential DisGeNET Curated 1.071E-3 1.518E-2
1.006E-1
4.542E-1
2 139
28 C0085397 Pasteurellaceae Infections DisGeNET Curated 1.110E-3 1.518E-2
1.006E-1
4.708E-1
1 3
29 C0238294 MYOCARDITIS, ACTIVE DisGeNET BeFree 1.110E-3 1.518E-2
1.006E-1
4.708E-1
1 3
30 20081125:Reiner C-reactive protein GWAS 1.110E-3 1.518E-2
1.006E-1
4.708E-1
1 3
31 C1142127 Pneumococcal bacteraemia DisGeNET BeFree 1.110E-3 1.518E-2
1.006E-1
4.708E-1
1 3
32 C0678201 Terminal Ileitis DisGeNET BeFree 1.480E-3 1.518E-2
1.006E-1
6.277E-1
1 4
33 C1720775 Renal tubular necrosis DisGeNET BeFree 1.480E-3 1.518E-2
1.006E-1
6.277E-1
1 4
34 C0242301 furuncle DisGeNET BeFree 1.480E-3 1.518E-2
1.006E-1
6.277E-1
1 4
35 C0151950 Deep thrombophlebitis DisGeNET BeFree 1.480E-3 1.518E-2
1.006E-1
6.277E-1
1 4
36 C0221019 Sickle cell-beta-thalassemia DisGeNET Curated 1.480E-3 1.518E-2
1.006E-1
6.277E-1
1 4
37 C0744471 gram negative bacteremia DisGeNET BeFree 1.480E-3 1.518E-2
1.006E-1
6.277E-1
1 4
38 C0017658 Glomerulonephritis DisGeNET Curated 1.634E-3 1.518E-2
1.006E-1
6.927E-1
2 172
39 C1142423 Bacteremia due to Staphylococcus aureus DisGeNET BeFree 1.850E-3 1.518E-2
1.006E-1
7.845E-1
1 5
40 C0577698 Exercise-induced angina DisGeNET BeFree 1.850E-3 1.518E-2
1.006E-1
7.845E-1
1 5
41 C0747479 periodontal infection DisGeNET BeFree 1.850E-3 1.518E-2
1.006E-1
7.845E-1
1 5
42 C0268392 Localized amyloidosis DisGeNET BeFree 1.850E-3 1.518E-2
1.006E-1
7.845E-1
1 5
43 20090712:Elliott C-reactive protein levels GWAS 1.850E-3 1.518E-2
1.006E-1
7.845E-1
1 5
44 20081125:Amos Lung cancer GWAS 1.850E-3 1.518E-2
1.006E-1
7.845E-1
1 5
45 C0032463 Polycythemia Vera DisGeNET Curated 2.136E-3 1.518E-2
1.006E-1
9.056E-1
2 197
46 C0175697 Van der Woude syndrome DisGeNET Curated 2.136E-3 1.518E-2
1.006E-1
9.056E-1
2 197
47 C0003872 Arthritis, Psoriatic DisGeNET Curated 2.179E-3 1.518E-2
1.006E-1
9.238E-1
2 199
48 C0018813 Myocardial rupture DisGeNET BeFree 2.220E-3 1.518E-2
1.006E-1
9.412E-1
1 6
49 C0221214 Vascular ring DisGeNET Curated 2.220E-3 1.518E-2
1.006E-1
9.412E-1
1 6
50 C3714514 Infection DisGeNET Curated 2.220E-3 1.518E-2
1.006E-1
9.412E-1
1 6
Show 45 more annotations