1: GO: Molecular Function [Display Chart]
11 input genes in category / 14 annotations before applied cutoff / 18661 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0003678
|
DNA helicase activity
|
|
6.424E-13
|
8.993E-12
|
2.924E-11
|
8.993E-12
|
6
|
65
|
2
|
GO:0004386
|
helicase activity
|
|
2.498E-10
|
1.749E-9
|
5.686E-9
|
3.498E-9
|
6
|
172
|
3
|
GO:0003688
|
DNA replication origin binding
|
|
1.277E-8
|
5.961E-8
|
1.938E-7
|
1.788E-7
|
3
|
9
|
4
|
GO:0003697
|
single-stranded DNA binding
|
|
2.915E-7
|
1.020E-6
|
3.317E-6
|
4.081E-6
|
4
|
104
|
5
|
GO:0004003
|
ATP-dependent DNA helicase activity
|
|
2.436E-6
|
6.821E-6
|
2.218E-5
|
3.410E-5
|
3
|
47
|
6
|
GO:0008094
|
DNA-dependent ATPase activity
|
|
1.921E-5
|
4.482E-5
|
1.457E-4
|
2.689E-4
|
3
|
93
|
7
|
GO:0070035
|
purine NTP-dependent helicase activity
|
|
3.353E-5
|
5.868E-5
|
1.908E-4
|
4.694E-4
|
3
|
112
|
8
|
GO:0008026
|
ATP-dependent helicase activity
|
|
3.353E-5
|
5.868E-5
|
1.908E-4
|
4.694E-4
|
3
|
112
|
9
|
GO:0042623
|
ATPase activity, coupled
|
|
8.282E-4
|
1.288E-3
|
4.189E-3
|
1.159E-2
|
3
|
332
|
10
|
GO:0016887
|
ATPase activity
|
|
1.939E-3
|
2.715E-3
|
8.828E-3
|
2.715E-2
|
3
|
446
|
11
|
GO:0010997
|
anaphase-promoting complex binding
|
|
3.532E-3
|
4.495E-3
|
1.462E-2
|
4.945E-2
|
1
|
6
|
12
|
GO:0000217
|
DNA secondary structure binding
|
|
1.464E-2
|
1.708E-2
|
5.555E-2
|
2.050E-1
|
1
|
25
|
Show 7 more annotations
|
2: GO: Biological Process [Display Chart]
11 input genes in category / 83 annotations before applied cutoff / 18623 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0006270
|
DNA replication initiation
|
|
5.227E-24
|
4.339E-22
|
2.170E-21
|
4.339E-22
|
9
|
35
|
2
|
GO:0006261
|
DNA-dependent DNA replication
|
|
2.890E-21
|
1.199E-19
|
6.000E-19
|
2.399E-19
|
10
|
134
|
3
|
GO:0006260
|
DNA replication
|
|
7.777E-20
|
2.152E-18
|
1.076E-17
|
6.455E-18
|
11
|
346
|
4
|
GO:0000082
|
G1/S transition of mitotic cell cycle
|
|
1.527E-18
|
3.168E-17
|
1.584E-16
|
1.267E-16
|
10
|
247
|
5
|
GO:0044843
|
cell cycle G1/S phase transition
|
|
2.286E-18
|
3.794E-17
|
1.898E-16
|
1.897E-16
|
10
|
257
|
6
|
GO:0032508
|
DNA duplex unwinding
|
|
1.717E-12
|
2.375E-11
|
1.188E-10
|
1.425E-10
|
6
|
76
|
7
|
GO:0032392
|
DNA geometric change
|
|
2.546E-12
|
3.018E-11
|
1.510E-10
|
2.113E-10
|
6
|
81
|
8
|
GO:0006268
|
DNA unwinding involved in DNA replication
|
|
1.381E-11
|
1.432E-10
|
7.165E-10
|
1.146E-9
|
4
|
10
|
9
|
GO:0071103
|
DNA conformation change
|
|
5.281E-9
|
4.870E-8
|
2.436E-7
|
4.383E-7
|
6
|
285
|
10
|
GO:0010389
|
regulation of G2/M transition of mitotic cell cycle
|
|
5.695E-4
|
4.727E-3
|
2.364E-2
|
4.727E-2
|
2
|
61
|
11
|
GO:1902749
|
regulation of cell cycle G2/M phase transition
|
|
7.073E-4
|
5.337E-3
|
2.670E-2
|
5.871E-2
|
2
|
68
|
12
|
GO:0000727
|
double-strand break repair via break-induced replication
|
|
2.361E-3
|
1.633E-2
|
8.168E-2
|
1.959E-1
|
1
|
4
|
13
|
GO:0070318
|
positive regulation of G0 to G1 transition
|
|
2.950E-3
|
1.884E-2
|
9.422E-2
|
2.449E-1
|
1
|
5
|
14
|
GO:0010571
|
positive regulation of nuclear cell cycle DNA replication
|
|
3.539E-3
|
2.098E-2
|
1.050E-1
|
2.938E-1
|
1
|
6
|
15
|
GO:0033314
|
mitotic DNA replication checkpoint
|
|
4.128E-3
|
2.284E-2
|
1.143E-1
|
3.426E-1
|
1
|
7
|
16
|
GO:0000086
|
G2/M transition of mitotic cell cycle
|
|
5.751E-3
|
2.865E-2
|
1.433E-1
|
4.773E-1
|
2
|
197
|
17
|
GO:0070316
|
regulation of G0 to G1 transition
|
|
5.892E-3
|
2.865E-2
|
1.433E-1
|
4.891E-1
|
1
|
10
|
18
|
GO:0044839
|
cell cycle G2/M phase transition
|
|
6.212E-3
|
2.865E-2
|
1.433E-1
|
5.156E-1
|
2
|
205
|
19
|
GO:0045023
|
G0 to G1 transition
|
|
7.067E-3
|
3.087E-2
|
1.544E-1
|
5.866E-1
|
1
|
12
|
20
|
GO:0033262
|
regulation of nuclear cell cycle DNA replication
|
|
7.654E-3
|
3.176E-2
|
1.589E-1
|
6.353E-1
|
1
|
13
|
21
|
GO:2000105
|
positive regulation of DNA-dependent DNA replication
|
|
8.241E-3
|
3.257E-2
|
1.629E-1
|
6.840E-1
|
1
|
14
|
22
|
GO:0000076
|
DNA replication checkpoint
|
|
9.413E-3
|
3.435E-2
|
1.718E-1
|
7.813E-1
|
1
|
16
|
23
|
GO:0090068
|
positive regulation of cell cycle process
|
|
9.755E-3
|
3.435E-2
|
1.718E-1
|
8.097E-1
|
2
|
259
|
24
|
GO:0018105
|
peptidyl-serine phosphorylation
|
|
1.012E-2
|
3.435E-2
|
1.718E-1
|
8.400E-1
|
2
|
264
|
25
|
GO:0010971
|
positive regulation of G2/M transition of mitotic cell cycle
|
|
1.058E-2
|
3.435E-2
|
1.718E-1
|
8.784E-1
|
1
|
18
|
26
|
GO:1902751
|
positive regulation of cell cycle G2/M phase transition
|
|
1.117E-2
|
3.435E-2
|
1.718E-1
|
9.270E-1
|
1
|
19
|
27
|
GO:0018209
|
peptidyl-serine modification
|
|
1.117E-2
|
3.435E-2
|
1.718E-1
|
9.274E-1
|
2
|
278
|
28
|
GO:1901990
|
regulation of mitotic cell cycle phase transition
|
|
1.444E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
2
|
318
|
29
|
GO:0044818
|
mitotic G2/M transition checkpoint
|
|
1.467E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
1
|
25
|
30
|
GO:0033260
|
nuclear DNA replication
|
|
1.467E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
1
|
25
|
31
|
GO:0000083
|
regulation of transcription involved in G1/S transition of mitotic cell cycle
|
|
1.584E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
1
|
27
|
32
|
GO:0071364
|
cellular response to epidermal growth factor stimulus
|
|
1.584E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
1
|
27
|
33
|
GO:1901987
|
regulation of cell cycle phase transition
|
|
1.621E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
2
|
338
|
34
|
GO:0071353
|
cellular response to interleukin-4
|
|
1.700E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
1
|
29
|
35
|
GO:0045787
|
positive regulation of cell cycle
|
|
1.750E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
2
|
352
|
36
|
GO:0010972
|
negative regulation of G2/M transition of mitotic cell cycle
|
|
1.758E-2
|
4.054E-2
|
2.028E-1
|
1.000E0
|
1
|
30
|
37
|
GO:1902750
|
negative regulation of cell cycle G2/M phase transition
|
|
1.874E-2
|
4.094E-2
|
2.048E-1
|
1.000E0
|
1
|
32
|
38
|
GO:0070849
|
response to epidermal growth factor
|
|
1.874E-2
|
4.094E-2
|
2.048E-1
|
1.000E0
|
1
|
32
|
39
|
GO:0044786
|
cell cycle DNA replication
|
|
1.991E-2
|
4.130E-2
|
2.066E-1
|
1.000E0
|
1
|
34
|
40
|
GO:0070670
|
response to interleukin-4
|
|
1.991E-2
|
4.130E-2
|
2.066E-1
|
1.000E0
|
1
|
34
|
41
|
GO:0031572
|
G2 DNA damage checkpoint
|
|
2.222E-2
|
4.499E-2
|
2.250E-1
|
1.000E0
|
1
|
38
|
Show 36 more annotations
|
3: GO: Cellular Component [Display Chart]
11 input genes in category / 22 annotations before applied cutoff / 19061 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0042555
|
MCM complex
|
|
3.203E-18
|
7.047E-17
|
2.601E-16
|
7.047E-17
|
6
|
11
|
2
|
GO:0000784
|
nuclear chromosome, telomeric region
|
|
2.214E-13
|
2.435E-12
|
8.988E-12
|
4.870E-12
|
7
|
133
|
3
|
GO:0000781
|
chromosome, telomeric region
|
|
9.018E-13
|
6.613E-12
|
2.441E-11
|
1.984E-11
|
7
|
162
|
4
|
GO:0098687
|
chromosomal region
|
|
1.820E-10
|
1.001E-9
|
3.695E-9
|
4.004E-9
|
7
|
344
|
5
|
GO:0005664
|
nuclear origin of replication recognition complex
|
|
1.199E-8
|
4.395E-8
|
1.622E-7
|
2.637E-7
|
3
|
9
|
6
|
GO:0000808
|
origin recognition complex
|
|
1.199E-8
|
4.395E-8
|
1.622E-7
|
2.637E-7
|
3
|
9
|
7
|
GO:0043596
|
nuclear replication fork
|
|
2.452E-4
|
7.708E-4
|
2.845E-3
|
5.395E-3
|
2
|
41
|
8
|
GO:0005657
|
replication fork
|
|
6.559E-4
|
1.804E-3
|
6.657E-3
|
1.443E-2
|
2
|
67
|
9
|
GO:0005658
|
alpha DNA polymerase:primase complex
|
|
2.307E-3
|
5.638E-3
|
2.081E-2
|
5.074E-2
|
1
|
4
|
10
|
GO:0031298
|
replication fork protection complex
|
|
3.458E-3
|
7.608E-3
|
2.808E-2
|
7.608E-2
|
1
|
6
|
11
|
GO:0043601
|
nuclear replisome
|
|
1.604E-2
|
3.209E-2
|
1.184E-1
|
3.530E-1
|
1
|
28
|
12
|
GO:0030894
|
replisome
|
|
1.775E-2
|
3.254E-2
|
1.201E-1
|
3.905E-1
|
1
|
31
|
13
|
GO:0016235
|
aggresome
|
|
2.002E-2
|
3.388E-2
|
1.250E-1
|
4.404E-1
|
1
|
35
|
14
|
GO:0045171
|
intercellular bridge
|
|
2.511E-2
|
3.945E-2
|
1.456E-1
|
5.524E-1
|
1
|
44
|
15
|
GO:0000785
|
chromatin
|
|
3.076E-2
|
4.511E-2
|
1.665E-1
|
6.767E-1
|
2
|
487
|
Show 10 more annotations
|
4: Human Phenotype [Display Chart]
5 input genes in category / 241 annotations before applied cutoff / 4707 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
HP:0006628
|
Absent sternal ossification
|
|
5.413E-6
|
1.304E-3
|
7.910E-3
|
1.304E-3
|
2
|
4
|
2
|
HP:0011863
|
Abnormal sternal ossification
|
|
2.522E-5
|
2.026E-3
|
1.228E-2
|
6.077E-3
|
2
|
8
|
3
|
HP:0003561
|
Birth length less than 3rd percentile
|
|
2.522E-5
|
2.026E-3
|
1.228E-2
|
6.077E-3
|
2
|
8
|
4
|
HP:0011267
|
Microtia, third degree
|
|
4.947E-5
|
2.981E-3
|
1.807E-2
|
1.192E-2
|
2
|
11
|
5
|
HP:0009892
|
Anotia
|
|
8.174E-5
|
3.267E-3
|
1.981E-2
|
1.970E-2
|
2
|
14
|
6
|
HP:0009939
|
Mandibular aplasia
|
|
8.174E-5
|
3.267E-3
|
1.981E-2
|
1.970E-2
|
2
|
14
|
7
|
HP:0100783
|
Breast aplasia
|
|
1.077E-4
|
3.267E-3
|
1.981E-2
|
2.596E-2
|
2
|
16
|
8
|
HP:0006660
|
Aplastic clavicle
|
|
1.220E-4
|
3.267E-3
|
1.981E-2
|
2.940E-2
|
2
|
17
|
9
|
HP:0000064
|
Hypoplastic labia minora
|
|
1.220E-4
|
3.267E-3
|
1.981E-2
|
2.940E-2
|
2
|
17
|
10
|
HP:0006443
|
Patellar aplasia
|
|
1.702E-4
|
4.103E-3
|
2.488E-2
|
4.103E-2
|
2
|
20
|
11
|
HP:0006714
|
Aplasia/Hypoplasia of the sternum
|
|
2.469E-4
|
5.409E-3
|
3.280E-2
|
5.950E-2
|
2
|
24
|
12
|
HP:0012880
|
Abnormality of the labia minora
|
|
2.905E-4
|
5.833E-3
|
3.537E-2
|
7.000E-2
|
2
|
26
|
13
|
HP:0000059
|
Hypoplastic labia majora
|
|
3.375E-4
|
6.257E-3
|
3.795E-2
|
8.135E-2
|
2
|
28
|
14
|
HP:0000060
|
Clitoral hypoplasia
|
|
4.705E-4
|
7.083E-3
|
4.295E-2
|
1.134E-1
|
2
|
33
|
15
|
HP:0006498
|
Aplasia/Hypoplasia of the patella
|
|
4.705E-4
|
7.083E-3
|
4.295E-2
|
1.134E-1
|
2
|
33
|
16
|
HP:0040255
|
Aplasia/Hypoplasia of the clitoris
|
|
4.705E-4
|
7.083E-3
|
4.295E-2
|
1.134E-1
|
2
|
33
|
17
|
HP:0012881
|
Abnormality of the labia majora
|
|
4.997E-4
|
7.083E-3
|
4.295E-2
|
1.204E-1
|
2
|
34
|
18
|
HP:0000898
|
Hypoplastic clavicles
|
|
5.606E-4
|
7.111E-3
|
4.312E-2
|
1.351E-1
|
2
|
36
|
19
|
HP:0000039
|
Epispadias
|
|
5.606E-4
|
7.111E-3
|
4.312E-2
|
1.351E-1
|
2
|
36
|
20
|
HP:0006710
|
Aplasia/Hypoplasia of the clavicles
|
|
6.251E-4
|
7.214E-3
|
4.375E-2
|
1.506E-1
|
2
|
38
|
21
|
HP:0002970
|
Genu varum
|
|
6.586E-4
|
7.214E-3
|
4.375E-2
|
1.587E-1
|
2
|
39
|
22
|
HP:0003187
|
Breast hypoplasia
|
|
6.586E-4
|
7.214E-3
|
4.375E-2
|
1.587E-1
|
2
|
39
|
23
|
HP:0000066
|
Labial hypoplasia
|
|
6.929E-4
|
7.261E-3
|
4.403E-2
|
1.670E-1
|
2
|
40
|
24
|
HP:0006591
|
Absent glenoid fossa
|
|
1.062E-3
|
1.067E-2
|
6.468E-2
|
2.560E-1
|
1
|
1
|
25
|
HP:0012815
|
Hypoplastic female external genitalia
|
|
1.217E-3
|
1.114E-2
|
6.756E-2
|
2.934E-1
|
2
|
53
|
26
|
HP:0000413
|
Atresia of the external auditory canal
|
|
1.359E-3
|
1.114E-2
|
6.756E-2
|
3.275E-1
|
2
|
56
|
27
|
HP:0000176
|
Submucous cleft hard palate
|
|
1.559E-3
|
1.114E-2
|
6.756E-2
|
3.757E-1
|
2
|
60
|
28
|
HP:0040253
|
Increased size of the clitoris
|
|
1.559E-3
|
1.114E-2
|
6.756E-2
|
3.757E-1
|
2
|
60
|
29
|
HP:0040252
|
Abnormal size of the clitoris
|
|
1.559E-3
|
1.114E-2
|
6.756E-2
|
3.757E-1
|
2
|
60
|
30
|
HP:0008665
|
Clitoral hypertrophy
|
|
1.559E-3
|
1.114E-2
|
6.756E-2
|
3.757E-1
|
2
|
60
|
31
|
HP:0410031
|
Submucous cleft of soft and hard palate
|
|
1.559E-3
|
1.114E-2
|
6.756E-2
|
3.757E-1
|
2
|
60
|
32
|
HP:0010311
|
Aplasia/Hypoplasia of the breasts
|
|
1.611E-3
|
1.114E-2
|
6.756E-2
|
3.883E-1
|
2
|
61
|
33
|
HP:0410005
|
Cleft hard palate
|
|
1.611E-3
|
1.114E-2
|
6.756E-2
|
3.883E-1
|
2
|
61
|
34
|
HP:0000208
|
Submucous cleft lip/palate
|
|
1.611E-3
|
1.114E-2
|
6.756E-2
|
3.883E-1
|
2
|
61
|
35
|
HP:0000908
|
Hypoplastic ribs
|
|
1.664E-3
|
1.114E-2
|
6.756E-2
|
4.011E-1
|
2
|
62
|
36
|
HP:0000773
|
Short ribs
|
|
1.664E-3
|
1.114E-2
|
6.756E-2
|
4.011E-1
|
2
|
62
|
37
|
HP:0000058
|
Abnormality of the labia
|
|
1.828E-3
|
1.191E-2
|
7.221E-2
|
4.406E-1
|
2
|
65
|
38
|
HP:0003042
|
Elbow dislocation
|
|
2.118E-3
|
1.221E-2
|
7.404E-2
|
5.105E-1
|
2
|
70
|
39
|
HP:0025129
|
Abnormal small intestinal mucosa morphology
|
|
2.124E-3
|
1.221E-2
|
7.404E-2
|
5.118E-1
|
1
|
2
|
40
|
HP:0000911
|
Flat glenoid fossa
|
|
2.124E-3
|
1.221E-2
|
7.404E-2
|
5.118E-1
|
1
|
2
|
41
|
HP:0025130
|
Decreased small intestinal mucosa lactase activity
|
|
2.124E-3
|
1.221E-2
|
7.404E-2
|
5.118E-1
|
1
|
2
|
42
|
HP:0003045
|
Abnormality of the patella
|
|
2.179E-3
|
1.221E-2
|
7.404E-2
|
5.250E-1
|
2
|
71
|
43
|
HP:0030310
|
Upper extremity joint dislocation
|
|
2.179E-3
|
1.221E-2
|
7.404E-2
|
5.250E-1
|
2
|
71
|
44
|
HP:0410004
|
Cleft secondary palate
|
|
2.240E-3
|
1.227E-2
|
7.440E-2
|
5.398E-1
|
2
|
72
|
45
|
HP:0000372
|
Abnormality of the auditory canal
|
|
2.493E-3
|
1.335E-2
|
8.097E-2
|
6.009E-1
|
2
|
76
|
46
|
HP:0003100
|
Slender long bone
|
|
2.625E-3
|
1.346E-2
|
8.162E-2
|
6.326E-1
|
2
|
78
|
47
|
HP:0003061
|
Gracile long bones
|
|
2.625E-3
|
1.346E-2
|
8.162E-2
|
6.326E-1
|
2
|
78
|
48
|
HP:0004789
|
Lactose intolerance
|
|
3.184E-3
|
1.599E-2
|
9.694E-2
|
7.674E-1
|
1
|
3
|
49
|
HP:0000193
|
Bifid uvula
|
|
3.483E-3
|
1.713E-2
|
1.039E-1
|
8.393E-1
|
2
|
90
|
50
|
HP:0006712
|
Aplasia/Hypoplasia of the ribs
|
|
3.794E-3
|
1.829E-2
|
1.109E-1
|
9.145E-1
|
2
|
94
|
Show 45 more annotations
|
5: Mouse Phenotype [Display Chart]
11 input genes in category / 158 annotations before applied cutoff / 10355 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
MP:0008866
|
chromosomal instability
|
|
8.055E-8
|
6.920E-6
|
3.905E-5
|
1.273E-5
|
5
|
119
|
2
|
MP:0010094
|
abnormal chromosome stability
|
|
8.759E-8
|
6.920E-6
|
3.905E-5
|
1.384E-5
|
5
|
121
|
3
|
MP:0002399
|
abnormal pluripotent precursor cell morphology
|
|
3.226E-7
|
1.699E-5
|
9.587E-5
|
5.097E-5
|
3
|
14
|
4
|
MP:0011913
|
abnormal reticulocyte cell number
|
|
3.757E-6
|
1.468E-4
|
8.281E-4
|
5.936E-4
|
4
|
110
|
5
|
MP:0002424
|
abnormal reticulocyte morphology
|
|
4.644E-6
|
1.468E-4
|
8.281E-4
|
7.338E-4
|
4
|
116
|
6
|
MP:0011091
|
prenatal lethality, complete penetrance
|
|
3.354E-5
|
8.832E-4
|
4.984E-3
|
5.299E-3
|
5
|
404
|
7
|
MP:0011101
|
prenatal lethality, incomplete penetrance
|
|
4.895E-5
|
1.105E-3
|
6.234E-3
|
7.734E-3
|
5
|
437
|
8
|
MP:0012431
|
increased lymphoma incidence
|
|
1.034E-4
|
2.043E-3
|
1.153E-2
|
1.634E-2
|
4
|
255
|
9
|
MP:0002640
|
reticulocytosis
|
|
1.170E-4
|
2.054E-3
|
1.159E-2
|
1.849E-2
|
3
|
95
|
10
|
MP:0010296
|
increased hemolymphoid system tumor incidence
|
|
2.067E-4
|
2.970E-3
|
1.676E-2
|
3.267E-2
|
4
|
305
|
11
|
MP:0013663
|
increased myeloid cell number
|
|
2.067E-4
|
2.970E-3
|
1.676E-2
|
3.267E-2
|
4
|
305
|
12
|
MP:0003077
|
abnormal cell cycle
|
|
2.864E-4
|
3.768E-3
|
2.126E-2
|
4.526E-2
|
4
|
332
|
13
|
MP:0011704
|
decreased fibroblast proliferation
|
|
3.100E-4
|
3.768E-3
|
2.126E-2
|
4.898E-2
|
3
|
132
|
14
|
MP:0008057
|
abnormal DNA replication
|
|
3.549E-4
|
4.006E-3
|
2.260E-2
|
5.608E-2
|
2
|
27
|
15
|
MP:0011702
|
abnormal fibroblast proliferation
|
|
7.085E-4
|
7.463E-3
|
4.211E-2
|
1.119E-1
|
3
|
175
|
16
|
MP:0020414
|
abnormal fibroblast physiology
|
|
2.323E-3
|
2.294E-2
|
1.294E-1
|
3.670E-1
|
3
|
264
|
17
|
MP:0010288
|
increased gland tumor incidence
|
|
3.065E-3
|
2.849E-2
|
1.608E-1
|
4.843E-1
|
3
|
291
|
18
|
MP:0002718
|
abnormal inner cell mass morphology
|
|
3.253E-3
|
2.855E-2
|
1.611E-1
|
5.139E-1
|
2
|
82
|
19
|
MP:0002026
|
increased leukemia incidence
|
|
4.076E-3
|
3.390E-2
|
1.913E-1
|
6.441E-1
|
2
|
92
|
20
|
MP:0010299
|
increased mammary gland tumor incidence
|
|
4.892E-3
|
3.790E-2
|
2.139E-1
|
7.730E-1
|
2
|
101
|
21
|
MP:0002024
|
increased T cell derived lymphoma incidence
|
|
5.180E-3
|
3.790E-2
|
2.139E-1
|
8.184E-1
|
2
|
104
|
22
|
MP:0010365
|
increased thymus tumor incidence
|
|
5.277E-3
|
3.790E-2
|
2.139E-1
|
8.338E-1
|
2
|
105
|
23
|
MP:0014127
|
increased thymoma incidence
|
|
6.358E-3
|
4.368E-2
|
2.465E-1
|
1.000E0
|
1
|
6
|
Show 18 more annotations
|
6: Domain [Display Chart]
11 input genes in category / 53 annotations before applied cutoff / 18735 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
IPR018525
|
MCM CS
|
InterPro
|
7.698E-21
|
1.360E-19
|
6.198E-19
|
4.080E-19
|
6
|
6
|
2
|
PF14551
|
MCM N
|
Pfam
|
7.698E-21
|
1.360E-19
|
6.198E-19
|
4.080E-19
|
6
|
6
|
3
|
IPR027925
|
MCM N
|
InterPro
|
7.698E-21
|
1.360E-19
|
6.198E-19
|
4.080E-19
|
6
|
6
|
4
|
PF17207
|
MCM OB
|
Pfam
|
2.155E-19
|
1.631E-18
|
7.434E-18
|
1.142E-17
|
6
|
8
|
5
|
PS50051
|
MCM 2
|
PROSITE
|
2.155E-19
|
1.631E-18
|
7.434E-18
|
1.142E-17
|
6
|
8
|
6
|
PS00847
|
MCM 1
|
PROSITE
|
2.155E-19
|
1.631E-18
|
7.434E-18
|
1.142E-17
|
6
|
8
|
7
|
IPR033762
|
MCM OB
|
InterPro
|
2.155E-19
|
1.631E-18
|
7.434E-18
|
1.142E-17
|
6
|
8
|
8
|
IPR001208
|
MCM dom
|
InterPro
|
6.462E-19
|
3.114E-18
|
1.419E-17
|
3.425E-17
|
6
|
9
|
9
|
IPR031327
|
MCM
|
InterPro
|
6.462E-19
|
3.114E-18
|
1.419E-17
|
3.425E-17
|
6
|
9
|
10
|
PF00493
|
MCM
|
Pfam
|
6.462E-19
|
3.114E-18
|
1.419E-17
|
3.425E-17
|
6
|
9
|
11
|
SM00350
|
MCM
|
SMART
|
6.462E-19
|
3.114E-18
|
1.419E-17
|
3.425E-17
|
6
|
9
|
12
|
IPR012340
|
NA-bd OB-fold
|
InterPro
|
3.074E-12
|
1.358E-11
|
6.186E-11
|
1.629E-10
|
6
|
84
|
13
|
IPR003593
|
AAA+ ATPase
|
InterPro
|
1.059E-6
|
4.010E-6
|
1.827E-5
|
5.614E-5
|
4
|
144
|
14
|
SM00382
|
AAA
|
SMART
|
1.059E-6
|
4.010E-6
|
1.827E-5
|
5.614E-5
|
4
|
144
|
15
|
2.20.28.10
|
-
|
Gene3D
|
1.879E-6
|
6.225E-6
|
2.837E-5
|
9.960E-5
|
2
|
4
|
16
|
IPR004039
|
Rubredoxin-type fold
|
InterPro
|
1.879E-6
|
6.225E-6
|
2.837E-5
|
9.960E-5
|
2
|
4
|
17
|
PF12619
|
MCM2 N
|
Pfam
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
18
|
PF05460
|
ORC6
|
Pfam
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
19
|
PF09329
|
zf-primase
|
Pfam
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
20
|
IPR020529
|
ORC6 met/pln
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
21
|
IPR008049
|
MCM6
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
22
|
IPR008046
|
Mcm3
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
23
|
PF09332
|
Mcm10
|
Pfam
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
24
|
PD315657
|
Origin recog cplx su6-like
|
ProDom
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
25
|
IPR008050
|
MCM7
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
26
|
IPR015411
|
Rep factor Mcm10 C
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
27
|
IPR008721
|
ORC6
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
28
|
IPR008047
|
MCM 4
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
29
|
IPR008048
|
MCM5
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
30
|
IPR015408
|
Znf Mcm10/DnaG
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
31
|
IPR008045
|
MCM2
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
32
|
SM01280
|
Mcm10
|
SMART
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
33
|
IPR024146
|
Claspin
|
InterPro
|
5.871E-4
|
9.430E-4
|
4.297E-3
|
3.112E-2
|
1
|
1
|
34
|
IPR015163
|
Cdc6 C
|
InterPro
|
1.174E-3
|
1.728E-3
|
7.876E-3
|
6.222E-2
|
1
|
2
|
35
|
SM01074
|
Cdc6 C
|
SMART
|
1.174E-3
|
1.728E-3
|
7.876E-3
|
6.222E-2
|
1
|
2
|
36
|
PF09079
|
Cdc6 C
|
Pfam
|
1.174E-3
|
1.728E-3
|
7.876E-3
|
6.222E-2
|
1
|
2
|
37
|
SM00439
|
BAH
|
SMART
|
6.441E-3
|
8.535E-3
|
3.889E-2
|
3.414E-1
|
1
|
11
|
38
|
PF01426
|
BAH
|
Pfam
|
6.441E-3
|
8.535E-3
|
3.889E-2
|
3.414E-1
|
1
|
11
|
39
|
PS51038
|
BAH
|
PROSITE
|
6.441E-3
|
8.535E-3
|
3.889E-2
|
3.414E-1
|
1
|
11
|
40
|
IPR001025
|
BAH dom
|
InterPro
|
6.441E-3
|
8.535E-3
|
3.889E-2
|
3.414E-1
|
1
|
11
|
41
|
IPR013763
|
Cyclin-like
|
InterPro
|
2.497E-2
|
3.227E-2
|
1.471E-1
|
1.000E0
|
1
|
43
|
42
|
PF00004
|
AAA
|
Pfam
|
3.012E-2
|
3.801E-2
|
1.732E-1
|
1.000E0
|
1
|
52
|
43
|
IPR003959
|
ATPase AAA core
|
InterPro
|
3.126E-2
|
3.853E-2
|
1.756E-1
|
1.000E0
|
1
|
54
|
Show 38 more annotations
|
7: Pathway [Display Chart]
11 input genes in category / 42 annotations before applied cutoff / 12450 genes in category
|
8: Pubmed [Display Chart]
11 input genes in category / 812 annotations before applied cutoff / 38193 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
15226314
|
Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.
|
Pubmed
|
1.198E-38
|
9.726E-36
|
7.078E-35
|
9.726E-36
|
11
|
19
|
2
|
15707391
|
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.
|
Pubmed
|
1.118E-37
|
4.539E-35
|
3.303E-34
|
9.078E-35
|
11
|
22
|
3
|
15232106
|
Self-assembling protein microarrays.
|
Pubmed
|
1.817E-31
|
4.918E-29
|
3.579E-28
|
1.476E-28
|
10
|
30
|
4
|
12791985
|
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
|
Pubmed
|
7.930E-31
|
1.610E-28
|
1.172E-27
|
6.439E-28
|
10
|
34
|
5
|
11095689
|
The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.
|
Pubmed
|
1.321E-30
|
2.146E-28
|
1.561E-27
|
1.073E-27
|
9
|
16
|
6
|
12045100
|
DNA replication in eukaryotic cells.
|
Pubmed
|
5.615E-30
|
7.598E-28
|
5.530E-27
|
4.559E-27
|
9
|
18
|
7
|
12614612
|
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
|
Pubmed
|
1.939E-29
|
2.250E-27
|
1.637E-26
|
1.575E-26
|
9
|
20
|
8
|
10436018
|
The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.
|
Pubmed
|
9.458E-27
|
9.600E-25
|
6.986E-24
|
7.680E-24
|
8
|
15
|
9
|
16899510
|
Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
|
Pubmed
|
1.123E-25
|
1.013E-23
|
7.373E-23
|
9.118E-23
|
7
|
8
|
10
|
10846177
|
Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.
|
Pubmed
|
5.053E-25
|
4.103E-23
|
2.986E-22
|
4.103E-22
|
7
|
9
|
11
|
11931757
|
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
|
Pubmed
|
2.294E-24
|
1.694E-22
|
1.233E-21
|
1.863E-21
|
8
|
26
|
12
|
22540012
|
Interactions of the human MCM-BP protein with MCM complex components and Dbf4.
|
Pubmed
|
1.111E-23
|
6.941E-22
|
5.051E-21
|
9.024E-21
|
7
|
12
|
13
|
24299456
|
Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.
|
Pubmed
|
1.111E-23
|
6.941E-22
|
5.051E-21
|
9.024E-21
|
7
|
12
|
14
|
15236977
|
Pairwise interactions of the six human MCM protein subunits.
|
Pubmed
|
1.072E-22
|
5.121E-21
|
3.727E-20
|
8.706E-20
|
6
|
6
|
15
|
9099751
|
In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.
|
Pubmed
|
1.072E-22
|
5.121E-21
|
3.727E-20
|
8.706E-20
|
6
|
6
|
16
|
22918583
|
The eukaryotic Mcm2-7 replicative helicase.
|
Pubmed
|
1.072E-22
|
5.121E-21
|
3.727E-20
|
8.706E-20
|
6
|
6
|
17
|
21220507
|
Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.
|
Pubmed
|
1.072E-22
|
5.121E-21
|
3.727E-20
|
8.706E-20
|
6
|
6
|
18
|
17296731
|
Identification and characterization of a novel component of the human minichromosome maintenance complex.
|
Pubmed
|
7.504E-22
|
3.047E-20
|
2.217E-19
|
6.093E-19
|
6
|
7
|
19
|
8798650
|
Binding of human minichromosome maintenance proteins with histone H3.
|
Pubmed
|
7.504E-22
|
3.047E-20
|
2.217E-19
|
6.093E-19
|
6
|
7
|
20
|
11248027
|
Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.
|
Pubmed
|
7.504E-22
|
3.047E-20
|
2.217E-19
|
6.093E-19
|
6
|
7
|
21
|
23993743
|
FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.
|
Pubmed
|
3.001E-21
|
1.160E-19
|
8.445E-19
|
2.437E-18
|
6
|
8
|
22
|
21149733
|
L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.
|
Pubmed
|
9.003E-21
|
3.323E-19
|
2.418E-18
|
7.310E-18
|
6
|
9
|
23
|
21055985
|
A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.
|
Pubmed
|
2.250E-20
|
7.614E-19
|
5.541E-18
|
1.827E-17
|
6
|
10
|
24
|
16902406
|
Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.
|
Pubmed
|
2.250E-20
|
7.614E-19
|
5.541E-18
|
1.827E-17
|
6
|
10
|
25
|
20838603
|
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.
|
Pubmed
|
6.824E-19
|
2.216E-17
|
1.613E-16
|
5.541E-16
|
5
|
5
|
26
|
20808282
|
A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.
|
Pubmed
|
1.080E-17
|
3.374E-16
|
2.455E-15
|
8.771E-15
|
6
|
23
|
27
|
23764002
|
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.
|
Pubmed
|
1.433E-17
|
4.155E-16
|
3.023E-15
|
1.163E-14
|
5
|
7
|
28
|
12364596
|
Human Mcm proteins at a replication origin during the G1 to S phase transition.
|
Pubmed
|
1.433E-17
|
4.155E-16
|
3.023E-15
|
1.163E-14
|
5
|
7
|
29
|
19135898
|
Purification of proteins associated with specific genomic Loci.
|
Pubmed
|
3.050E-17
|
8.539E-16
|
6.214E-15
|
2.476E-14
|
7
|
76
|
30
|
19862764
|
Analysis of interaction partners of H4 histone by a new proteomics approach.
|
Pubmed
|
3.166E-17
|
8.570E-16
|
6.236E-15
|
2.571E-14
|
6
|
27
|
31
|
27621311
|
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.
|
Pubmed
|
5.080E-17
|
1.331E-15
|
9.683E-15
|
4.125E-14
|
6
|
29
|
32
|
10567526
|
Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity.
|
Pubmed
|
3.723E-15
|
8.397E-14
|
6.111E-13
|
3.023E-12
|
4
|
4
|
33
|
12694531
|
Mammalian Mcm2/4/6/7 complex forms a toroidal structure.
|
Pubmed
|
3.723E-15
|
8.397E-14
|
6.111E-13
|
3.023E-12
|
4
|
4
|
34
|
8265339
|
The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
|
Pubmed
|
3.723E-15
|
8.397E-14
|
6.111E-13
|
3.023E-12
|
4
|
4
|
35
|
12207017
|
Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
|
Pubmed
|
3.723E-15
|
8.397E-14
|
6.111E-13
|
3.023E-12
|
4
|
4
|
36
|
20421204
|
Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.
|
Pubmed
|
3.723E-15
|
8.397E-14
|
6.111E-13
|
3.023E-12
|
4
|
4
|
37
|
10748114
|
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2.
|
Pubmed
|
1.861E-14
|
4.084E-13
|
2.972E-12
|
1.511E-11
|
4
|
5
|
38
|
24190967
|
A role for USP7 in DNA replication.
|
Pubmed
|
5.582E-14
|
1.193E-12
|
8.681E-12
|
4.533E-11
|
4
|
6
|
39
|
12519773
|
The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding.
|
Pubmed
|
1.302E-13
|
2.712E-12
|
1.973E-11
|
1.058E-10
|
4
|
7
|
40
|
20508983
|
Centrosome-related genes, genetic variation, and risk of breast cancer.
|
Pubmed
|
1.428E-13
|
2.899E-12
|
2.110E-11
|
1.160E-10
|
6
|
102
|
41
|
10523313
|
Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.
|
Pubmed
|
2.604E-13
|
5.158E-12
|
3.754E-11
|
2.115E-10
|
4
|
8
|
42
|
26527279
|
Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.
|
Pubmed
|
4.882E-12
|
9.363E-11
|
6.813E-10
|
3.964E-9
|
6
|
182
|
43
|
10454562
|
MCM proteins are associated with RNA polymerase II holoenzyme.
|
Pubmed
|
5.073E-12
|
9.363E-11
|
6.813E-10
|
4.120E-9
|
4
|
15
|
44
|
22407294
|
Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply.
|
Pubmed
|
5.073E-12
|
9.363E-11
|
6.813E-10
|
4.120E-9
|
4
|
15
|
45
|
25661590
|
G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.
|
Pubmed
|
1.777E-11
|
2.488E-10
|
1.811E-9
|
1.443E-8
|
3
|
3
|
46
|
7601140
|
A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.
|
Pubmed
|
1.777E-11
|
2.488E-10
|
1.811E-9
|
1.443E-8
|
3
|
3
|
47
|
19318354
|
The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription.
|
Pubmed
|
1.777E-11
|
2.488E-10
|
1.811E-9
|
1.443E-8
|
3
|
3
|
48
|
7610039
|
Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins.
|
Pubmed
|
1.777E-11
|
2.488E-10
|
1.811E-9
|
1.443E-8
|
3
|
3
|
49
|
9305914
|
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
|
Pubmed
|
1.777E-11
|
2.488E-10
|
1.811E-9
|
1.443E-8
|
3
|
3
|
50
|
9077461
|
Mouse MCM proteins: complex formation and transportation to the nucleus.
|
Pubmed
|
1.777E-11
|
2.488E-10
|
1.811E-9
|
1.443E-8
|
3
|
3
|
Show 45 more annotations
|
9: Interaction [Display Chart]
11 input genes in category / 1278 annotations before applied cutoff / 17703 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
int:CDC7
|
CDC7 interactions
|
|
1.730E-30
|
2.210E-27
|
1.709E-26
|
2.210E-27
|
11
|
40
|
2
|
int:DBF4
|
DBF4 interactions
|
|
7.452E-22
|
4.762E-19
|
3.681E-18
|
9.523E-19
|
8
|
25
|
3
|
int:MCM6
|
MCM6 interactions
|
|
2.147E-21
|
9.148E-19
|
7.072E-18
|
2.744E-18
|
10
|
124
|
4
|
int:ORC2
|
ORC2 interactions
|
|
5.737E-21
|
1.541E-18
|
1.192E-17
|
7.331E-18
|
9
|
68
|
5
|
int:MCM4
|
MCM4 interactions
|
|
6.030E-21
|
1.541E-18
|
1.192E-17
|
7.706E-18
|
10
|
137
|
6
|
int:MCM7
|
MCM7 interactions
|
|
3.097E-19
|
6.596E-17
|
5.099E-16
|
3.958E-16
|
10
|
201
|
7
|
int:ORC5
|
ORC5 interactions
|
|
3.685E-19
|
6.728E-17
|
5.201E-16
|
4.709E-16
|
8
|
50
|
8
|
int:ORC4
|
ORC4 interactions
|
|
4.370E-19
|
6.981E-17
|
5.397E-16
|
5.585E-16
|
8
|
51
|
9
|
int:ORC6
|
ORC6 interactions
|
|
1.299E-17
|
1.844E-15
|
1.426E-14
|
1.660E-14
|
7
|
33
|
10
|
int:CDC45
|
CDC45 interactions
|
|
4.671E-17
|
5.969E-15
|
4.614E-14
|
5.969E-14
|
7
|
39
|
11
|
int:ORC1
|
ORC1 interactions
|
|
5.362E-16
|
6.229E-14
|
4.816E-13
|
6.852E-13
|
7
|
54
|
12
|
int:MCMBP
|
MCMBP interactions
|
|
7.019E-16
|
7.475E-14
|
5.779E-13
|
8.970E-13
|
7
|
56
|
13
|
int:MCM5
|
MCM5 interactions
|
|
1.289E-15
|
1.267E-13
|
9.796E-13
|
1.647E-12
|
9
|
256
|
14
|
int:MCM10
|
MCM10 interactions
|
|
1.672E-15
|
1.526E-13
|
1.180E-12
|
2.137E-12
|
7
|
63
|
15
|
int:MCM3
|
MCM3 interactions
|
|
4.896E-15
|
4.171E-13
|
3.225E-12
|
6.257E-12
|
8
|
156
|
16
|
int:CDC6
|
CDC6 interactions
|
|
1.047E-14
|
8.364E-13
|
6.466E-12
|
1.338E-11
|
7
|
81
|
17
|
int:TONSL
|
TONSL interactions
|
|
2.091E-14
|
1.572E-12
|
1.215E-11
|
2.673E-11
|
6
|
36
|
18
|
int:ORC3
|
ORC3 interactions
|
|
1.003E-13
|
7.124E-12
|
5.507E-11
|
1.282E-10
|
6
|
46
|
19
|
int:ASF1B
|
ASF1B interactions
|
|
4.323E-13
|
2.908E-11
|
2.248E-10
|
5.525E-10
|
6
|
58
|
20
|
int:L3MBTL1
|
L3MBTL1 interactions
|
|
7.062E-12
|
4.513E-10
|
3.489E-9
|
9.026E-9
|
6
|
91
|
21
|
int:SSRP1
|
SSRP1 interactions
|
|
1.376E-10
|
8.376E-9
|
6.475E-8
|
1.759E-7
|
6
|
148
|
22
|
int:CAP1
|
CAP1 interactions
|
|
1.868E-10
|
1.085E-8
|
8.389E-8
|
2.387E-7
|
5
|
61
|
23
|
int:CDT1
|
CDT1 interactions
|
|
2.802E-10
|
1.557E-8
|
1.204E-7
|
3.581E-7
|
5
|
66
|
24
|
int:HIST1H4A
|
HIST1H4A interactions
|
|
7.527E-10
|
4.008E-8
|
3.099E-7
|
9.620E-7
|
6
|
196
|
25
|
int:HIST1H3E
|
HIST1H3E interactions
|
|
9.301E-10
|
4.754E-8
|
3.675E-7
|
1.189E-6
|
6
|
203
|
26
|
int:MMS22L
|
MMS22L interactions
|
|
1.405E-9
|
6.908E-8
|
5.340E-7
|
1.796E-6
|
4
|
27
|
27
|
int:TIPIN
|
TIPIN interactions
|
|
1.901E-9
|
8.997E-8
|
6.955E-7
|
2.429E-6
|
4
|
29
|
28
|
int:HIST1H2BA
|
HIST1H2BA interactions
|
|
2.110E-9
|
9.632E-8
|
7.446E-7
|
2.697E-6
|
5
|
98
|
29
|
int:PLK1
|
PLK1 interactions
|
|
6.146E-9
|
2.709E-7
|
2.094E-6
|
7.855E-6
|
6
|
278
|
30
|
int:CCND1
|
CCND1 interactions
|
|
6.667E-9
|
2.840E-7
|
2.196E-6
|
8.520E-6
|
5
|
123
|
31
|
int:ILF2
|
ILF2 interactions
|
|
1.249E-8
|
5.149E-7
|
3.980E-6
|
1.596E-5
|
6
|
313
|
32
|
int:GINS4
|
GINS4 interactions
|
|
2.151E-8
|
8.590E-7
|
6.641E-6
|
2.749E-5
|
4
|
52
|
33
|
int:HDAC5
|
HDAC5 interactions
|
|
2.736E-8
|
1.060E-6
|
8.193E-6
|
3.497E-5
|
6
|
357
|
34
|
int:ING5
|
ING5 interactions
|
|
3.364E-8
|
1.265E-6
|
9.776E-6
|
4.300E-5
|
4
|
58
|
35
|
int:TIMELESS
|
TIMELESS interactions
|
|
9.078E-8
|
3.315E-6
|
2.563E-5
|
1.160E-4
|
4
|
74
|
36
|
int:VCAM1
|
VCAM1 interactions
|
|
1.170E-7
|
4.155E-6
|
3.212E-5
|
1.496E-4
|
6
|
456
|
37
|
int:CDKN2A
|
CDKN2A interactions
|
|
1.347E-7
|
4.653E-6
|
3.597E-5
|
1.722E-4
|
5
|
224
|
38
|
int:ASF1A
|
ASF1A interactions
|
|
1.669E-7
|
5.604E-6
|
4.332E-5
|
2.133E-4
|
4
|
86
|
39
|
int:SF3A1
|
SF3A1 interactions
|
|
1.710E-7
|
5.604E-6
|
4.332E-5
|
2.186E-4
|
5
|
235
|
40
|
int:RPA1
|
RPA1 interactions
|
|
1.948E-7
|
6.223E-6
|
4.810E-5
|
2.489E-4
|
6
|
497
|
41
|
int:RELCH
|
RELCH interactions
|
|
2.023E-7
|
6.305E-6
|
4.875E-5
|
2.585E-4
|
3
|
20
|
42
|
int:SPAG9
|
SPAG9 interactions
|
|
2.391E-7
|
7.275E-6
|
5.624E-5
|
3.055E-4
|
4
|
94
|
43
|
int:HIST2H2BF
|
HIST2H2BF interactions
|
|
2.731E-7
|
7.755E-6
|
5.996E-5
|
3.490E-4
|
3
|
22
|
44
|
int:SBNO1
|
SBNO1 interactions
|
|
2.731E-7
|
7.755E-6
|
5.996E-5
|
3.490E-4
|
3
|
22
|
45
|
int:CCL2
|
CCL2 interactions
|
|
2.731E-7
|
7.755E-6
|
5.996E-5
|
3.490E-4
|
3
|
22
|
46
|
int:SPIN2B
|
SPIN2B interactions
|
|
3.587E-7
|
9.965E-6
|
7.703E-5
|
4.584E-4
|
3
|
24
|
47
|
int:SF3B1
|
SF3B1 interactions
|
|
4.858E-7
|
1.321E-5
|
1.021E-4
|
6.208E-4
|
5
|
290
|
48
|
int:HIST1H3A
|
HIST1H3A interactions
|
|
7.663E-7
|
2.026E-5
|
1.566E-4
|
9.794E-4
|
5
|
318
|
49
|
int:SENP3
|
SENP3 interactions
|
|
7.767E-7
|
2.026E-5
|
1.566E-4
|
9.927E-4
|
4
|
126
|
50
|
int:ATG2B
|
ATG2B interactions
|
|
7.946E-7
|
2.031E-5
|
1.570E-4
|
1.016E-3
|
3
|
31
|
Show 45 more annotations
|
10: Cytoband [Display Chart]
11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
8q11.2
|
8q11.2
|
|
1.586E-3
|
6.977E-3
|
2.107E-2
|
1.744E-2
|
1
|
5
|
2
|
16q12
|
16q12
|
|
1.903E-3
|
6.977E-3
|
2.107E-2
|
2.093E-2
|
1
|
6
|
3
|
7q21.3-q22.1
|
7q21.3-q22.1
|
|
1.903E-3
|
6.977E-3
|
2.107E-2
|
2.093E-2
|
1
|
6
|
4
|
2q21
|
2q21
|
|
5.067E-3
|
1.160E-2
|
3.504E-2
|
5.573E-2
|
1
|
16
|
5
|
6p12
|
6p12
|
|
5.383E-3
|
1.160E-2
|
3.504E-2
|
5.921E-2
|
1
|
17
|
6
|
1p22
|
1p22
|
|
6.330E-3
|
1.160E-2
|
3.504E-2
|
6.963E-2
|
1
|
20
|
7
|
3q21
|
3q21
|
|
7.591E-3
|
1.174E-2
|
3.545E-2
|
8.351E-2
|
1
|
24
|
8
|
1p32
|
1p32
|
|
8.537E-3
|
1.174E-2
|
3.545E-2
|
9.390E-2
|
1
|
27
|
9
|
10p13
|
10p13
|
|
1.450E-2
|
1.773E-2
|
5.353E-2
|
1.595E-1
|
1
|
46
|
10
|
1p34.2
|
1p34.2
|
|
1.826E-2
|
2.008E-2
|
6.064E-2
|
2.008E-1
|
1
|
58
|
11
|
22q13.1
|
22q13.1
|
|
2.789E-2
|
2.789E-2
|
8.422E-2
|
3.068E-1
|
1
|
89
|
Show 6 more annotations
|
11: Transcription Factor Binding Site [Display Chart]
9 input genes in category / 52 annotations before applied cutoff / 9770 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
V$E2F1 Q6
|
V$E2F1 Q6
|
|
2.328E-11
|
8.224E-10
|
3.732E-9
|
1.211E-9
|
7
|
181
|
2
|
V$E2F1 Q6 01
|
V$E2F1 Q6 01
|
|
3.163E-11
|
8.224E-10
|
3.732E-9
|
1.645E-9
|
7
|
189
|
3
|
SGCGSSAAA V$E2F1DP2 01
|
SGCGSSAAA V$E2F1DP2 01
|
|
4.211E-10
|
7.299E-9
|
3.312E-8
|
2.190E-8
|
6
|
131
|
4
|
V$E2F Q3
|
V$E2F Q3
|
|
2.609E-9
|
1.432E-8
|
6.498E-8
|
1.357E-7
|
6
|
177
|
5
|
V$E2F Q6
|
V$E2F Q6
|
|
3.087E-9
|
1.432E-8
|
6.498E-8
|
1.605E-7
|
6
|
182
|
6
|
V$E2F1DP2 01
|
V$E2F1DP2 01
|
|
3.298E-9
|
1.432E-8
|
6.498E-8
|
1.715E-7
|
6
|
184
|
7
|
V$E2F 02
|
V$E2F 02
|
|
3.298E-9
|
1.432E-8
|
6.498E-8
|
1.715E-7
|
6
|
184
|
8
|
V$E2F Q4
|
V$E2F Q4
|
|
3.298E-9
|
1.432E-8
|
6.498E-8
|
1.715E-7
|
6
|
184
|
9
|
V$E2F4DP2 01
|
V$E2F4DP2 01
|
|
3.298E-9
|
1.432E-8
|
6.498E-8
|
1.715E-7
|
6
|
184
|
10
|
V$E2F Q6 01
|
V$E2F Q6 01
|
|
3.298E-9
|
1.432E-8
|
6.498E-8
|
1.715E-7
|
6
|
184
|
11
|
V$E2F1DP1 01
|
V$E2F1DP1 01
|
|
3.298E-9
|
1.432E-8
|
6.498E-8
|
1.715E-7
|
6
|
184
|
12
|
V$E2F Q4 01
|
V$E2F Q4 01
|
|
3.407E-9
|
1.432E-8
|
6.498E-8
|
1.772E-7
|
6
|
185
|
13
|
V$E2F4DP1 01
|
V$E2F4DP1 01
|
|
3.877E-9
|
1.432E-8
|
6.498E-8
|
2.016E-7
|
6
|
189
|
14
|
V$E2F1 Q3
|
V$E2F1 Q3
|
|
4.002E-9
|
1.432E-8
|
6.498E-8
|
2.081E-7
|
6
|
190
|
15
|
V$E2F 03
|
V$E2F 03
|
|
4.131E-9
|
1.432E-8
|
6.498E-8
|
2.148E-7
|
6
|
191
|
16
|
KTGGYRSGAA UNKNOWN
|
KTGGYRSGAA UNKNOWN
|
|
1.109E-7
|
3.605E-7
|
1.636E-6
|
5.768E-6
|
4
|
55
|
17
|
V$E2F1 Q4 01
|
V$E2F1 Q4 01
|
|
2.451E-7
|
7.496E-7
|
3.402E-6
|
1.274E-5
|
5
|
181
|
18
|
V$E2F1DP1RB 01
|
V$E2F1DP1RB 01
|
|
2.660E-7
|
7.684E-7
|
3.487E-6
|
1.383E-5
|
5
|
184
|
19
|
V$E2F Q3 01
|
V$E2F Q3 01
|
|
2.808E-7
|
7.684E-7
|
3.487E-6
|
1.460E-5
|
5
|
186
|
20
|
V$E2F 01
|
V$E2F 01
|
|
1.385E-5
|
3.600E-5
|
1.634E-4
|
7.200E-4
|
3
|
55
|
21
|
V$E2F1 Q4
|
V$E2F1 Q4
|
|
1.225E-2
|
3.035E-2
|
1.377E-1
|
6.373E-1
|
2
|
189
|
22
|
V$FOXO1 01
|
V$FOXO1 01
|
|
1.379E-2
|
3.258E-2
|
1.479E-1
|
7.168E-1
|
2
|
201
|
Show 17 more annotations
|
12: Gene Family [Display Chart]
8 input genes in category / 4 annotations before applied cutoff / 18194 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
1085
|
MCM family
|
genenames.org
|
4.671E-20
|
1.869E-19
|
3.893E-19
|
1.869E-19
|
6
|
9
|
2
|
960
|
Origin recognition complex
|
genenames.org
|
2.536E-6
|
5.071E-6
|
1.056E-5
|
1.014E-5
|
2
|
6
|
3
|
413
|
AAA ATPases
|
genenames.org
|
2.307E-2
|
3.076E-2
|
6.409E-2
|
9.229E-2
|
1
|
53
|
|
13: Coexpression [Display Chart]
11 input genes in category / 1343 annotations before applied cutoff / 23137 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
20548326-Table4
|
Human Stomach Bonelli10 61genes
|
GeneSigDB
|
2.063E-19
|
2.770E-16
|
2.155E-15
|
2.770E-16
|
8
|
60
|
2
|
M9372
|
Genes involved in DNA replication, compiled manually by the authors.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.723E-19
|
4.515E-16
|
3.513E-15
|
9.029E-16
|
9
|
146
|
3
|
15374877-Table2
|
Human StemCell Manalo05 108genes
|
GeneSigDB
|
2.587E-18
|
1.158E-15
|
9.010E-15
|
3.474E-15
|
8
|
81
|
4
|
17145885-SuppTable2
|
Human Lung Kobayashi06 320genes
|
GeneSigDB
|
8.403E-17
|
2.178E-14
|
1.694E-13
|
1.129E-13
|
9
|
247
|
5
|
18218118-Table1
|
Mouse Pancreas Thakur08 75genes
|
GeneSigDB
|
9.449E-17
|
2.178E-14
|
1.694E-13
|
1.269E-13
|
7
|
55
|
6
|
M16010
|
Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
9.730E-17
|
2.178E-14
|
1.694E-13
|
1.307E-13
|
9
|
251
|
7
|
M4455
|
RB1 [GeneID=5925] target genes involved in cell cycle regulation: genes down-regulated by doxorubicin [PubChem=31703] only in cells expressing RB1.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.183E-16
|
4.189E-14
|
3.259E-13
|
2.932E-13
|
6
|
23
|
8
|
M19048
|
Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.679E-16
|
4.497E-14
|
3.499E-13
|
3.598E-13
|
8
|
142
|
9
|
M123
|
Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
4.794E-16
|
7.153E-14
|
5.565E-13
|
6.438E-13
|
9
|
299
|
10
|
M4288
|
Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.856E-15
|
2.493E-13
|
1.939E-12
|
2.493E-12
|
8
|
180
|
11
|
18427120-DataS4
|
Human Breast Crawford08 971genes
|
GeneSigDB
|
2.590E-15
|
3.162E-13
|
2.460E-12
|
3.478E-12
|
9
|
360
|
12
|
17471573-Table2
|
Human Viral Santegoets07 103genes
|
GeneSigDB
|
2.941E-15
|
3.292E-13
|
2.561E-12
|
3.950E-12
|
7
|
88
|
13
|
M2132
|
Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChem=176158], an inhibitor of GSK3B [GeneID=2932].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.661E-15
|
3.782E-13
|
2.942E-12
|
4.916E-12
|
9
|
374
|
14
|
M1577
|
Strongly up-regulated at 16-24 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
7.953E-15
|
7.410E-13
|
5.765E-12
|
1.068E-11
|
7
|
101
|
15
|
17510386-Table4
|
Human HeadandNeck Pyeon07 42genes
|
GeneSigDB
|
8.276E-15
|
7.410E-13
|
5.765E-12
|
1.111E-11
|
6
|
40
|
16
|
20630075-AF-2
|
Mouse StemCell GarciaEscudero10 371genes p53
|
GeneSigDB
|
4.268E-14
|
3.583E-12
|
2.787E-11
|
5.732E-11
|
8
|
265
|
17
|
M1915
|
Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.103E-14
|
4.821E-12
|
3.751E-11
|
8.196E-11
|
8
|
277
|
18
|
M18562
|
Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
8.593E-14
|
6.411E-12
|
4.988E-11
|
1.154E-10
|
8
|
289
|
19
|
M2156
|
Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.159E-13
|
1.526E-11
|
1.187E-10
|
2.899E-10
|
8
|
324
|
20
|
M1871
|
Set 'ES exp1': genes overexpressed in human embryonic stem cells according to 5 or more out of 20 profiling studies.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
7.615E-13
|
5.113E-11
|
3.978E-10
|
1.023E-9
|
8
|
379
|
21
|
M4533
|
Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3600] at 16 h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.040E-12
|
6.292E-11
|
4.896E-10
|
1.397E-9
|
7
|
200
|
22
|
M5925
|
Genes encoding cell cycle related targets of E2F transcription factors.
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
1.040E-12
|
6.292E-11
|
4.896E-10
|
1.397E-9
|
7
|
200
|
23
|
M14340
|
Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.078E-12
|
6.292E-11
|
4.896E-10
|
1.447E-9
|
7
|
201
|
24
|
M2151
|
Genes up-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChem=5757] treatment.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.709E-12
|
1.516E-10
|
1.179E-9
|
3.638E-9
|
7
|
229
|
25
|
18231642-TableW1
|
Mouse Brain DeSmaele07 122genes
|
GeneSigDB
|
3.428E-12
|
1.842E-10
|
1.433E-9
|
4.604E-9
|
6
|
105
|
26
|
15489886-TableS1b
|
Human Sarcoma Mason04 549genes
|
GeneSigDB
|
3.858E-12
|
1.993E-10
|
1.550E-9
|
5.181E-9
|
8
|
464
|
27
|
M1681
|
Cluster 4: genes maximally expressed at 16 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes in response to adipogenic hormones.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
5.463E-12
|
2.717E-10
|
2.114E-9
|
7.337E-9
|
5
|
40
|
28
|
18547747-Table1
|
Human Leukemia Mollinedo08 117genes
|
GeneSigDB
|
6.648E-12
|
3.189E-10
|
2.481E-9
|
8.928E-9
|
6
|
117
|
29
|
16919171-Table3
|
Human Colon Ancona06 45genes
|
GeneSigDB
|
7.059E-12
|
3.269E-10
|
2.543E-9
|
9.481E-9
|
5
|
42
|
30
|
17072343-Table1
|
Human Ovarian Basaki07 46genes YB-1infected
|
GeneSigDB
|
1.013E-11
|
4.536E-10
|
3.529E-9
|
1.361E-8
|
5
|
45
|
31
|
M14985
|
Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.429E-11
|
6.193E-10
|
4.818E-9
|
1.920E-8
|
7
|
290
|
32
|
M11250
|
Genes down-regulated in MCF-7 cells (breast cancer) by selective estrogen receptor modulators (SERM) 4-hydroxytamoxifen, raloxifene, or ICI 182780 but not by estradiol [PubChem=44959;5035;3478439;5757].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.755E-11
|
7.366E-10
|
5.731E-9
|
2.357E-8
|
5
|
50
|
33
|
M2074
|
Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G1/S phase of cell cycle.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.671E-11
|
1.087E-9
|
8.458E-9
|
3.588E-8
|
6
|
147
|
34
|
M10169
|
Genes downstream of both CDKN1A and TP53 [GeneID=1026;7157] in 2774qw1 cells (ovarian cancer).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.879E-11
|
1.137E-9
|
8.847E-9
|
3.866E-8
|
5
|
55
|
35
|
M2180
|
The XPRSS-Int network genes up-regulated in breast tumors from patients with germline mutations in BRCA1 [GeneID=672] compared to those with the wild type allele.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.160E-11
|
1.213E-9
|
9.435E-9
|
4.244E-8
|
5
|
56
|
36
|
17150101-TableS1l
|
Human Breast Troester06 436genes-up-DOX-ZR75-1
|
GeneSigDB
|
3.467E-11
|
1.293E-9
|
1.006E-8
|
4.656E-8
|
7
|
329
|
37
|
M7079
|
The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.935E-11
|
1.428E-9
|
1.111E-8
|
5.285E-8
|
7
|
335
|
38
|
19139136-TableS2
|
Human Prostate John-Aryankalayil09 450genes
|
GeneSigDB
|
4.277E-11
|
1.490E-9
|
1.159E-8
|
5.744E-8
|
7
|
339
|
39
|
17804718-HumanGeneList
|
Human Breast Deeb07 61genesHumanGeneListHumanGeneList
|
GeneSigDB
|
4.515E-11
|
1.490E-9
|
1.159E-8
|
6.063E-8
|
5
|
60
|
40
|
M2257
|
Cellular genes up-regulated in forskin fibroblasts by expression of CMV EI86 protein off an adenovirus vector.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
4.515E-11
|
1.490E-9
|
1.159E-8
|
6.063E-8
|
5
|
60
|
41
|
M2879
|
Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
4.549E-11
|
1.490E-9
|
1.159E-8
|
6.110E-8
|
7
|
342
|
42
|
18662380-S3-AURKA
|
Human Breast Wirapati08 355genes AURKA Module
|
GeneSigDB
|
4.739E-11
|
1.515E-9
|
1.179E-8
|
6.365E-8
|
7
|
344
|
43
|
M2431
|
DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
4.917E-11
|
1.536E-9
|
1.195E-8
|
6.603E-8
|
5
|
61
|
44
|
14750170-Table2
|
Mouse Intestine DeGiovanni04 68genes
|
GeneSigDB
|
6.820E-11
|
2.082E-9
|
1.620E-8
|
9.160E-8
|
5
|
65
|
45
|
M2961
|
Genes down-regulated in natural T reg versus T conv.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
9.122E-11
|
2.723E-9
|
2.118E-8
|
1.225E-7
|
6
|
180
|
46
|
M2984
|
Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 12h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
9.753E-11
|
2.847E-9
|
2.215E-8
|
1.310E-7
|
6
|
182
|
47
|
M16458
|
Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.627E-10
|
4.586E-9
|
3.568E-8
|
2.185E-7
|
5
|
77
|
48
|
15150092-Table1
|
Human StemCell Medjkane04 23genes
|
GeneSigDB
|
1.648E-10
|
4.586E-9
|
3.568E-8
|
2.213E-7
|
4
|
21
|
49
|
M3171
|
Genes up-regulated in comparison of germinal center B cells versus memory B cells.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.673E-10
|
4.586E-9
|
3.568E-8
|
2.247E-7
|
6
|
199
|
50
|
M5901
|
Genes involved in the G2/M checkpoint, as in progression through the cell division cycle.
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
1.725E-10
|
4.633E-9
|
3.604E-8
|
2.316E-7
|
6
|
200
|
Show 45 more annotations
|
14: Coexpression Atlas [Display Chart]
11 input genes in category / 599 annotations before applied cutoff / 21829 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GSM538387 500
|
alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3
|
Immgen.org, GSE15907
|
8.986E-20
|
3.250E-17
|
2.266E-16
|
5.383E-17
|
11
|
410
|
2
|
GSM399403 500
|
alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.085E-19
|
3.250E-17
|
2.266E-16
|
6.499E-17
|
11
|
417
|
3
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes
|
BrainMap
|
4.326E-18
|
5.183E-16
|
3.614E-15
|
2.591E-15
|
10
|
320
|
4
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200
|
|
4.326E-18
|
5.183E-16
|
3.614E-15
|
2.591E-15
|
10
|
320
|
5
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes
|
|
4.326E-18
|
5.183E-16
|
3.614E-15
|
2.591E-15
|
10
|
320
|
6
|
GSM791143 500
|
alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
3.830E-17
|
3.823E-15
|
2.666E-14
|
2.294E-14
|
10
|
397
|
7
|
GSM399452 500
|
B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3
|
Immgen.org, GSE15907
|
5.173E-17
|
4.427E-15
|
3.087E-14
|
3.099E-14
|
10
|
409
|
8
|
GSM538348 500
|
B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2
|
Immgen.org, GSE15907
|
6.601E-17
|
4.500E-15
|
3.138E-14
|
3.954E-14
|
10
|
419
|
9
|
GSM791141 500
|
alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2
|
Immgen.org, GSE15907
|
6.762E-17
|
4.500E-15
|
3.138E-14
|
4.050E-14
|
10
|
420
|
10
|
GSM791154 500
|
alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
6.476E-15
|
3.879E-13
|
2.705E-12
|
3.879E-12
|
9
|
376
|
11
|
GSM538207 500
|
B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3
|
Immgen.org, GSE15907
|
7.128E-15
|
3.882E-13
|
2.707E-12
|
4.270E-12
|
9
|
380
|
12
|
GSM538358 500
|
B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3
|
Immgen.org, GSE15907
|
1.135E-14
|
5.663E-13
|
3.949E-12
|
6.796E-12
|
9
|
400
|
13
|
GSM476660 500
|
gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3
|
Immgen.org, GSE15907
|
1.549E-14
|
6.491E-13
|
4.527E-12
|
9.280E-12
|
9
|
414
|
14
|
GSM476664 500
|
gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3
|
Immgen.org, GSE15907
|
1.727E-14
|
6.491E-13
|
4.527E-12
|
1.035E-11
|
9
|
419
|
15
|
GSM791136 500
|
alpha beta T cells, preT.DN2.Th, Lin-/lo CD25hi CD44+ cKit+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.765E-14
|
6.491E-13
|
4.527E-12
|
1.057E-11
|
9
|
420
|
16
|
GSM538355 500
|
B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2
|
Immgen.org, GSE15907
|
1.842E-14
|
6.491E-13
|
4.527E-12
|
1.104E-11
|
9
|
422
|
17
|
GSM538357 500
|
B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1
|
Immgen.org, GSE15907
|
1.842E-14
|
6.491E-13
|
4.527E-12
|
1.104E-11
|
9
|
422
|
18
|
BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Dlx1 Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Dlx1 Top 200 Genes
|
BrainMap
|
5.957E-13
|
1.917E-11
|
1.337E-10
|
3.568E-10
|
8
|
347
|
19
|
GSM605773 500
|
alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2
|
Immgen.org, GSE15907
|
7.828E-13
|
1.917E-11
|
1.337E-10
|
4.689E-10
|
8
|
359
|
20
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes
|
|
8.003E-13
|
1.917E-11
|
1.337E-10
|
4.794E-10
|
7
|
182
|
21
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200
|
BrainMap
|
8.003E-13
|
1.917E-11
|
1.337E-10
|
4.794E-10
|
7
|
182
|
22
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes
|
BrainMap
|
8.003E-13
|
1.917E-11
|
1.337E-10
|
4.794E-10
|
7
|
182
|
23
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes
|
BrainMap
|
8.003E-13
|
1.917E-11
|
1.337E-10
|
4.794E-10
|
7
|
182
|
24
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes
|
BrainMap
|
8.003E-13
|
1.917E-11
|
1.337E-10
|
4.794E-10
|
7
|
182
|
25
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200
|
BrainMap
|
8.003E-13
|
1.917E-11
|
1.337E-10
|
4.794E-10
|
7
|
182
|
26
|
GSM538352 500
|
B cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2
|
Immgen.org, GSE15907
|
1.461E-12
|
3.365E-11
|
2.347E-10
|
8.750E-10
|
8
|
388
|
27
|
GSM538338 500
|
alpha beta T cells, NKT.44-NK1.1-.Th, aGC CD1d tet CD3e, Thymus, avg-2
|
Immgen.org, GSE15907
|
1.792E-12
|
3.975E-11
|
2.772E-10
|
1.073E-9
|
8
|
398
|
28
|
GSM605898 500
|
alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3
|
Immgen.org, GSE15907
|
1.941E-12
|
4.153E-11
|
2.896E-10
|
1.163E-9
|
8
|
402
|
29
|
GSM791149 500
|
alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.410E-12
|
4.979E-11
|
3.472E-10
|
1.444E-9
|
8
|
413
|
30
|
GSM538350 500
|
B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1
|
Immgen.org, GSE15907
|
2.654E-12
|
5.300E-11
|
3.696E-10
|
1.590E-9
|
8
|
418
|
31
|
GSM476658 500
|
gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2
|
Immgen.org, GSE15907
|
2.865E-12
|
5.363E-11
|
3.740E-10
|
1.716E-9
|
8
|
422
|
32
|
GSM791124 500
|
B cells, MLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R-, Bone marrow, avg-2
|
Immgen.org, GSE15907
|
2.865E-12
|
5.363E-11
|
3.740E-10
|
1.716E-9
|
8
|
422
|
33
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes
|
BrainMap
|
4.768E-11
|
8.655E-10
|
6.035E-9
|
2.856E-8
|
7
|
325
|
34
|
Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/2/3
|
Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/2/3
|
TCGA-Uterus
|
5.016E-11
|
8.838E-10
|
6.163E-9
|
3.005E-8
|
6
|
154
|
35
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes
|
BrainMap
|
7.546E-11
|
1.291E-9
|
9.006E-9
|
4.520E-8
|
7
|
347
|
36
|
GSM476675 500
|
gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3
|
Immgen.org, GSE15907
|
7.856E-11
|
1.307E-9
|
9.115E-9
|
4.706E-8
|
7
|
349
|
37
|
GSM399385 500
|
alpha beta T cells, T.8SP69+.Th, 4- 8+ TCRhi 69+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.015E-10
|
1.631E-9
|
1.137E-8
|
6.079E-8
|
7
|
362
|
38
|
GSM605784 500
|
gamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.035E-10
|
1.631E-9
|
1.137E-8
|
6.198E-8
|
7
|
363
|
39
|
6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s3 intermediate neurons Subtype intermediate neurons s3 Top 100 Genes
|
6mo cortical organoids wt 6mo cortical organoids wt Subtype intermediate neurons s3 intermediate neurons Subtype intermediate neurons s3 Top 100 Genes
|
|
1.089E-10
|
1.672E-9
|
1.166E-8
|
6.521E-8
|
6
|
175
|
40
|
GSM538309 500
|
NK cells, NK.MCMV1.Sp, CD3-,NK1.1+, Spleen, avg-3
|
Immgen.org, GSE15907
|
1.117E-10
|
1.673E-9
|
1.167E-8
|
6.692E-8
|
7
|
367
|
41
|
GSM605781 500
|
gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.251E-10
|
1.828E-9
|
1.275E-8
|
7.496E-8
|
7
|
373
|
42
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/pre-natural killer cell
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/pre-natural killer cell
|
Tabula Muris Consortium
|
1.524E-10
|
2.173E-9
|
1.515E-8
|
9.127E-8
|
6
|
185
|
43
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell
|
Tabula Muris Consortium
|
1.848E-10
|
2.574E-9
|
1.795E-8
|
1.107E-7
|
6
|
191
|
44
|
GSM399397 500
|
alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.005E-10
|
2.703E-9
|
1.885E-8
|
1.201E-7
|
7
|
399
|
45
|
Cap mesenchyme (CM)
|
Cap mesenchyme (CM)
|
|
2.030E-10
|
2.703E-9
|
1.885E-8
|
1.216E-7
|
6
|
194
|
46
|
GSM791139 500
|
alpha beta T cells, preT.DN2A.Th, Lin-/lo CD25hi CD44+ cKithi, Thymus, avg-2
|
Immgen.org, GSE15907
|
2.383E-10
|
3.103E-9
|
2.164E-8
|
1.427E-7
|
7
|
409
|
47
|
GSM605793 500
|
gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.508E-10
|
3.196E-9
|
2.229E-8
|
1.502E-7
|
7
|
412
|
48
|
GSM791134 500
|
alpha beta T cells, preT.DN2-3.Th, Lin-/lo CD25hi CD44Int, Thymus, avg-2
|
Immgen.org, GSE15907
|
2.638E-10
|
3.292E-9
|
2.296E-8
|
1.580E-7
|
7
|
415
|
49
|
GSM791131 500
|
B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3
|
Immgen.org, GSE15907
|
3.115E-10
|
3.808E-9
|
2.656E-8
|
1.866E-7
|
7
|
425
|
50
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Top 200
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Top 200
|
BrainMap
|
7.174E-10
|
8.594E-9
|
5.993E-8
|
4.297E-7
|
7
|
479
|
Show 45 more annotations
|
15: Computational [Display Chart]
10 input genes in category / 111 annotations before applied cutoff / 10037 genes in category
|
16: MicroRNA [Display Chart]
11 input genes in category / 289 annotations before applied cutoff / 72241 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
hsa-miR-373-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.195E-7
|
2.207E-5
|
1.378E-4
|
6.344E-5
|
4
|
371
|
2
|
hsa-miR-371b-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.219E-7
|
2.207E-5
|
1.378E-4
|
6.413E-5
|
4
|
372
|
3
|
hsa-miR-616-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.291E-7
|
2.207E-5
|
1.378E-4
|
6.622E-5
|
4
|
375
|
4
|
hsa-miR-4649-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.472E-7
|
2.662E-5
|
1.663E-4
|
1.292E-4
|
3
|
102
|
5
|
hsa-miR-6729-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.606E-7
|
2.662E-5
|
1.663E-4
|
1.331E-4
|
3
|
103
|
6
|
hsa-miR-372-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.490E-5
|
6.256E-4
|
3.907E-3
|
4.305E-3
|
3
|
328
|
7
|
hsa-miR-423-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.702E-5
|
6.256E-4
|
3.907E-3
|
4.919E-3
|
3
|
343
|
8
|
hsa-miR-371a-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.732E-5
|
6.256E-4
|
3.907E-3
|
5.005E-3
|
3
|
345
|
9
|
hsa-miR-4253:mirSVR highEffct
|
hsa-miR-4253:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
4.566E-5
|
1.421E-3
|
8.876E-3
|
1.320E-2
|
3
|
478
|
10
|
hsa-miR-501-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.917E-5
|
1.421E-3
|
8.876E-3
|
1.421E-2
|
2
|
69
|
11
|
hsa-miR-3141:mirSVR highEffct
|
hsa-miR-3141:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
6.618E-5
|
1.739E-3
|
1.086E-2
|
1.913E-2
|
2
|
80
|
12
|
hsa-miR-4486:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.057E-4
|
4.953E-3
|
3.093E-2
|
5.943E-2
|
2
|
141
|
13
|
hsa-miR-548p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.358E-4
|
5.241E-3
|
3.273E-2
|
6.814E-2
|
2
|
151
|
14
|
hsa-miR-3184-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
3.533E-4
|
7.294E-3
|
4.555E-2
|
1.021E-1
|
2
|
185
|
15
|
hsa-miR-6741-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.781E-4
|
1.114E-2
|
6.956E-2
|
1.671E-1
|
2
|
237
|
16
|
hsa-miR-4638-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.174E-4
|
1.115E-2
|
6.965E-2
|
1.784E-1
|
2
|
245
|
17
|
hsa-miR-93-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.431E-4
|
1.246E-2
|
7.784E-2
|
2.148E-1
|
2
|
269
|
18
|
hsa-miR-1260b:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.763E-4
|
1.246E-2
|
7.784E-2
|
2.244E-1
|
2
|
275
|
19
|
hsa-miR-6791-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.061E-3
|
1.411E-2
|
8.810E-2
|
3.066E-1
|
2
|
322
|
20
|
hsa-miR-6829-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.061E-3
|
1.411E-2
|
8.810E-2
|
3.066E-1
|
2
|
322
|
21
|
hsa-miR-3672:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.074E-3
|
1.411E-2
|
8.810E-2
|
3.103E-1
|
2
|
324
|
22
|
hsa-miR-6864-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.074E-3
|
1.411E-2
|
8.810E-2
|
3.103E-1
|
2
|
324
|
23
|
hsa-miR-140-3p.2:TargetScan
|
hsa-miR-140-3p.2
|
TargetScan
|
1.272E-3
|
1.598E-2
|
9.981E-2
|
3.676E-1
|
2
|
353
|
24
|
hsa-miR-504-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.556E-3
|
1.646E-2
|
1.028E-1
|
4.497E-1
|
2
|
391
|
25
|
hsa-miR-3135b:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.580E-3
|
1.646E-2
|
1.028E-1
|
4.565E-1
|
2
|
394
|
26
|
hsa-miR-222-3p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.580E-3
|
1.646E-2
|
1.028E-1
|
4.565E-1
|
2
|
394
|
27
|
hsa-miR-3652:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.603E-3
|
1.646E-2
|
1.028E-1
|
4.634E-1
|
2
|
397
|
28
|
hsa-miR-4430:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.603E-3
|
1.646E-2
|
1.028E-1
|
4.634E-1
|
2
|
397
|
29
|
hsa-miR-148b-3p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.651E-3
|
1.646E-2
|
1.028E-1
|
4.773E-1
|
2
|
403
|
30
|
hsa-miR-27a*:mirSVR highEffct
|
hsa-miR-27a*:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
1.885E-3
|
1.781E-2
|
1.112E-1
|
5.447E-1
|
2
|
431
|
31
|
hsa-miR-939-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.954E-3
|
1.781E-2
|
1.112E-1
|
5.648E-1
|
2
|
439
|
32
|
hsa-miR-184:mirSVR lowEffct
|
hsa-miR-184:mirSVR conserved lowEffect-0.1-0.5
|
MicroRNA.org
|
1.972E-3
|
1.781E-2
|
1.112E-1
|
5.698E-1
|
2
|
441
|
33
|
hsa-miR-661:Functional MTI
|
Functional MTI
|
miRTarbase
|
2.133E-3
|
1.804E-2
|
1.127E-1
|
6.164E-1
|
2
|
459
|
34
|
hsa-miR-6890-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.207E-3
|
1.804E-2
|
1.127E-1
|
6.377E-1
|
2
|
467
|
35
|
hsa-miR-7703:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.272E-3
|
1.804E-2
|
1.127E-1
|
6.566E-1
|
2
|
474
|
36
|
hsa-miR-508-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
2.300E-3
|
1.804E-2
|
1.127E-1
|
6.648E-1
|
2
|
477
|
37
|
hsa-miR-4304:mirSVR lowEffct
|
hsa-miR-4304:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.310E-3
|
1.804E-2
|
1.127E-1
|
6.675E-1
|
2
|
478
|
38
|
hsa-miR-662:Functional MTI
|
Functional MTI
|
miRTarbase
|
3.193E-3
|
2.366E-2
|
1.478E-1
|
9.228E-1
|
1
|
21
|
39
|
hsa-miR-147b:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
3.193E-3
|
2.366E-2
|
1.478E-1
|
9.228E-1
|
1
|
21
|
40
|
hsa-miR-6853-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.165E-3
|
3.732E-2
|
2.331E-1
|
1.000E0
|
1
|
34
|
41
|
hsa-miR-1301-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.468E-3
|
3.763E-2
|
2.350E-1
|
1.000E0
|
1
|
36
|
42
|
hsa-miR-6502-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.468E-3
|
3.763E-2
|
2.350E-1
|
1.000E0
|
1
|
36
|
43
|
hsa-miR-4766-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.771E-3
|
3.879E-2
|
2.423E-1
|
1.000E0
|
1
|
38
|
44
|
hsa-miR-1251-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.226E-3
|
4.089E-2
|
2.554E-1
|
1.000E0
|
1
|
41
|
45
|
hsa-miR-6820-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.377E-3
|
4.096E-2
|
2.558E-1
|
1.000E0
|
1
|
42
|
46
|
hsa-miR-517-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.134E-3
|
4.482E-2
|
2.799E-1
|
1.000E0
|
1
|
47
|
47
|
hsa-miR-5571-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.588E-3
|
4.557E-2
|
2.846E-1
|
1.000E0
|
1
|
50
|
48
|
hsa-miR-4259:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.890E-3
|
4.557E-2
|
2.846E-1
|
1.000E0
|
1
|
52
|
49
|
hsa-miR-6510-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
8.041E-3
|
4.557E-2
|
2.846E-1
|
1.000E0
|
1
|
53
|
50
|
hsa-miR-99b-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
8.041E-3
|
4.557E-2
|
2.846E-1
|
1.000E0
|
1
|
53
|
Show 45 more annotations
|
17: Drug [Display Chart]
11 input genes in category / 864 annotations before applied cutoff / 22841 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
ctd:C014026
|
hexamethylene bisacetamide
|
CTD
|
3.954E-19
|
3.416E-16
|
2.507E-15
|
3.416E-16
|
8
|
64
|
2
|
CID000003657
|
hydroxyurea
|
Stitch
|
1.718E-14
|
7.424E-12
|
5.449E-11
|
1.485E-11
|
9
|
438
|
3
|
ctd:D000069439
|
Dasatinib
|
CTD
|
5.165E-10
|
1.488E-7
|
1.092E-6
|
4.463E-7
|
7
|
478
|
4
|
CID000002210
|
NSC351140
|
Stitch
|
8.636E-10
|
1.865E-7
|
1.369E-6
|
7.461E-7
|
6
|
258
|
5
|
ctd:D012835
|
Silver Nitrate
|
CTD
|
1.589E-9
|
2.746E-7
|
2.015E-6
|
1.373E-6
|
5
|
119
|
6
|
ctd:D018021
|
Lithium Chloride
|
CTD
|
3.710E-9
|
5.343E-7
|
3.921E-6
|
3.206E-6
|
6
|
329
|
7
|
ctd:C006551
|
2-amino-2-methyl-1-propanol
|
CTD
|
4.929E-9
|
6.084E-7
|
4.465E-6
|
4.259E-6
|
6
|
345
|
8
|
ctd:C059765
|
amphotericin B, deoxycholate drug combination
|
CTD
|
1.025E-8
|
1.107E-6
|
8.125E-6
|
8.856E-6
|
6
|
390
|
9
|
6895 DN
|
0297417-0002B [362658-29-5]; Down 200; 10uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
1.909E-8
|
1.833E-6
|
1.345E-5
|
1.650E-5
|
5
|
195
|
10
|
ctd:D002509
|
Cephaloridine
|
CTD
|
3.193E-8
|
2.758E-6
|
2.024E-5
|
2.758E-5
|
6
|
472
|
11
|
ctd:C024015
|
cryptolepine
|
CTD
|
1.464E-7
|
1.150E-5
|
8.438E-5
|
1.265E-4
|
3
|
23
|
12
|
ctd:D001507
|
Beclomethasone
|
CTD
|
2.399E-7
|
1.727E-5
|
1.268E-4
|
2.073E-4
|
5
|
324
|
13
|
ctd:C058305
|
phenethyl isothiocyanate
|
CTD
|
7.324E-7
|
4.868E-5
|
3.573E-4
|
6.328E-4
|
5
|
406
|
14
|
ctd:C008493
|
methylselenic acid
|
CTD
|
7.969E-7
|
4.918E-5
|
3.610E-4
|
6.885E-4
|
5
|
413
|
15
|
CID000003134
|
6-DMAP
|
Stitch
|
1.015E-6
|
5.820E-5
|
4.272E-4
|
8.767E-4
|
3
|
43
|
16
|
ctd:C496197
|
trans-10,cis-12-conjugated linoleic acid
|
CTD
|
1.078E-6
|
5.820E-5
|
4.272E-4
|
9.313E-4
|
4
|
176
|
17
|
4452 DN
|
geldanamycin; Down 200; 1uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
1.463E-6
|
7.298E-5
|
5.356E-4
|
1.264E-3
|
4
|
190
|
18
|
1773 DN
|
Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; HL60; HG-U133A
|
Broad Institute CMAP Down
|
1.557E-6
|
7.298E-5
|
5.356E-4
|
1.345E-3
|
4
|
193
|
19
|
6902 DN
|
0297417-0002B [362658-29-5]; Down 200; 10uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
1.655E-6
|
7.298E-5
|
5.356E-4
|
1.430E-3
|
4
|
196
|
20
|
2439 DN
|
Menadione [58-27-5]; Down 200; 23.2uM; HL60; HT HG-U133A
|
Broad Institute CMAP Down
|
1.689E-6
|
7.298E-5
|
5.356E-4
|
1.460E-3
|
4
|
197
|
21
|
ctd:C030123
|
coumarin
|
CTD
|
2.179E-6
|
8.963E-5
|
6.578E-4
|
1.882E-3
|
4
|
210
|
22
|
CID000079034
|
1-2H
|
Stitch
|
2.527E-6
|
9.924E-5
|
7.284E-4
|
2.183E-3
|
3
|
58
|
23
|
CID000006623
|
bisphenol A
|
Stitch
|
2.766E-6
|
1.039E-4
|
7.626E-4
|
2.390E-3
|
4
|
223
|
24
|
ctd:D003345
|
Corticosterone
|
CTD
|
6.439E-6
|
2.318E-4
|
1.701E-3
|
5.564E-3
|
4
|
276
|
25
|
CID000028780
|
benomyl
|
Stitch
|
2.745E-5
|
9.486E-4
|
6.962E-3
|
2.371E-2
|
3
|
128
|
26
|
ctd:C494474
|
perchlorate
|
CTD
|
3.078E-5
|
1.023E-3
|
7.507E-3
|
2.659E-2
|
3
|
133
|
27
|
CID000072271
|
UCN-01
|
Stitch
|
4.766E-5
|
1.525E-3
|
1.119E-2
|
4.118E-2
|
3
|
154
|
28
|
ctd:C517041
|
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
|
CTD
|
5.295E-5
|
1.621E-3
|
1.190E-2
|
4.575E-2
|
4
|
472
|
29
|
ctd:D001622
|
Betaine
|
CTD
|
5.441E-5
|
1.621E-3
|
1.190E-2
|
4.701E-2
|
3
|
161
|
30
|
ctd:C105832
|
aurapten
|
CTD
|
5.786E-5
|
1.666E-3
|
1.223E-2
|
4.999E-2
|
2
|
24
|
31
|
4430 DN
|
17-AAG; Down 200; 1uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
8.092E-5
|
2.255E-3
|
1.655E-2
|
6.991E-2
|
3
|
184
|
32
|
CID000124245
|
hydroxymethylreductic acid
|
Stitch
|
8.500E-5
|
2.294E-3
|
1.684E-2
|
7.344E-2
|
2
|
29
|
33
|
6717 DN
|
Promethazine hydrochloride [58-33-3]; Down 200; 12.4uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
8.762E-5
|
2.294E-3
|
1.684E-2
|
7.570E-2
|
3
|
189
|
34
|
1409 DN
|
Etofylline [519-37-9]; Down 200; 17.8uM; HL60; HG-U133A
|
Broad Institute CMAP Down
|
9.467E-5
|
2.359E-3
|
1.732E-2
|
8.180E-2
|
3
|
194
|
35
|
1053 DN
|
prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT HG-U133A EA
|
Broad Institute CMAP Down
|
9.613E-5
|
2.359E-3
|
1.732E-2
|
8.305E-2
|
3
|
195
|
36
|
1732 DN
|
Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A
|
Broad Institute CMAP Down
|
9.908E-5
|
2.359E-3
|
1.732E-2
|
8.560E-2
|
3
|
197
|
37
|
4085 DN
|
Thioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; PC3; HT HG-U133A
|
Broad Institute CMAP Down
|
1.021E-4
|
2.359E-3
|
1.732E-2
|
8.820E-2
|
3
|
199
|
38
|
CID000002384
|
AC1L1DK5
|
Stitch
|
1.038E-4
|
2.359E-3
|
1.732E-2
|
8.965E-2
|
2
|
32
|
39
|
CID000010944
|
A-Mate
|
Stitch
|
1.104E-4
|
2.446E-3
|
1.796E-2
|
9.541E-2
|
2
|
33
|
40
|
ctd:D005031
|
Ethylenethiourea
|
CTD
|
1.244E-4
|
2.686E-3
|
1.972E-2
|
1.075E-1
|
2
|
35
|
41
|
CID000041322
|
anti-BaPDE
|
Stitch
|
1.648E-4
|
3.474E-3
|
2.549E-2
|
1.424E-1
|
3
|
234
|
42
|
CID000137566
|
4 A 3
|
Stitch
|
2.157E-4
|
4.335E-3
|
3.181E-2
|
1.864E-1
|
2
|
46
|
43
|
ctd:C121707
|
7,3'-dihydroxy-4'-methoxyisoflavone
|
CTD
|
2.157E-4
|
4.335E-3
|
3.181E-2
|
1.864E-1
|
2
|
46
|
44
|
ctd:D008769
|
Methylnitronitrosoguanidine
|
CTD
|
2.431E-4
|
4.774E-3
|
3.504E-2
|
2.101E-1
|
3
|
267
|
45
|
CID000412123
|
AC1L92T5
|
Stitch
|
3.201E-4
|
6.147E-3
|
4.511E-2
|
2.766E-1
|
2
|
56
|
46
|
CID000448249
|
O-Ir
|
Stitch
|
3.317E-4
|
6.230E-3
|
4.572E-2
|
2.866E-1
|
2
|
57
|
47
|
ctd:C014476
|
diethyl maleate
|
CTD
|
4.250E-4
|
7.812E-3
|
5.733E-2
|
3.672E-1
|
3
|
323
|
48
|
CID000323970
|
AC1L89QG
|
Stitch
|
4.721E-4
|
8.497E-3
|
6.236E-2
|
4.079E-1
|
2
|
68
|
49
|
ctd:D001285
|
Atropine
|
CTD
|
8.807E-4
|
1.553E-2
|
1.140E-1
|
7.609E-1
|
2
|
93
|
50
|
ctd:D010882
|
Piperonyl Butoxide
|
CTD
|
9.835E-4
|
1.700E-2
|
1.247E-1
|
8.498E-1
|
3
|
431
|
Show 45 more annotations
|
18: Disease [Display Chart]
11 input genes in category / 188 annotations before applied cutoff / 16205 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
C0025286
|
Meningioma
|
DisGeNET Curated
|
1.034E-7
|
1.945E-5
|
1.131E-4
|
1.945E-5
|
6
|
409
|
2
|
C1868684
|
EAR, PATELLA, SHORT STATURE SYNDROME
|
DisGeNET Curated
|
1.255E-6
|
1.180E-4
|
6.864E-4
|
2.360E-4
|
3
|
33
|
3
|
C4280443
|
Absent bone maturation in sternum
|
DisGeNET Curated
|
2.512E-6
|
1.180E-4
|
6.866E-4
|
4.722E-4
|
2
|
4
|
4
|
C1857074
|
Absent sternal ossification
|
DisGeNET Curated
|
2.512E-6
|
1.180E-4
|
6.866E-4
|
4.722E-4
|
2
|
4
|
5
|
C1855650
|
Birth length less than 3rd percentile
|
DisGeNET Curated
|
6.274E-6
|
2.359E-4
|
1.372E-3
|
1.180E-3
|
2
|
6
|
6
|
C0151779
|
Cutaneous Melanoma
|
DisGeNET Curated
|
1.676E-5
|
5.251E-4
|
3.054E-3
|
3.151E-3
|
4
|
250
|
7
|
C1868577
|
Patella aplasia-hypoplasia
|
DisGeNET Curated
|
3.254E-5
|
8.740E-4
|
5.083E-3
|
6.118E-3
|
2
|
13
|
8
|
C0007129
|
Merkel cell carcinoma
|
DisGeNET Curated
|
4.444E-5
|
1.044E-3
|
6.074E-3
|
8.354E-3
|
3
|
107
|
9
|
C1833144
|
Slender, gracile long tubular bones
|
DisGeNET Curated
|
8.735E-5
|
1.825E-3
|
1.061E-2
|
1.642E-2
|
2
|
21
|
10
|
C0266013
|
Congenital hypoplasia of breast
|
DisGeNET Curated
|
1.349E-4
|
2.484E-3
|
1.445E-2
|
2.537E-2
|
2
|
26
|
11
|
C0426817
|
Short ribs
|
DisGeNET Curated
|
1.803E-4
|
2.484E-3
|
1.445E-2
|
3.391E-2
|
2
|
30
|
12
|
C0544755
|
Genu varum
|
DisGeNET Curated
|
1.803E-4
|
2.484E-3
|
1.445E-2
|
3.391E-2
|
2
|
30
|
13
|
C1512433
|
High Grade Cervical Squamous Intraepithelial Neoplasia
|
DisGeNET BeFree
|
1.927E-4
|
2.484E-3
|
1.445E-2
|
3.623E-2
|
2
|
31
|
14
|
C0021296
|
Infant, Small for Gestational Age
|
DisGeNET Curated
|
1.982E-4
|
2.484E-3
|
1.445E-2
|
3.726E-2
|
3
|
177
|
15
|
C1386048
|
Intrauterine retardation
|
DisGeNET Curated
|
1.982E-4
|
2.484E-3
|
1.445E-2
|
3.726E-2
|
3
|
177
|
16
|
C0015934
|
Fetal Growth Retardation
|
DisGeNET Curated
|
2.294E-4
|
2.696E-3
|
1.568E-2
|
4.313E-2
|
3
|
186
|
17
|
C0156394
|
Hypertrophy of clitoris
|
DisGeNET Curated
|
3.726E-4
|
4.120E-3
|
2.396E-2
|
7.004E-2
|
2
|
43
|
18
|
C0013336
|
Dwarfism
|
DisGeNET Curated
|
4.390E-4
|
4.586E-3
|
2.667E-2
|
8.254E-2
|
3
|
232
|
19
|
C0152423
|
Congenital small ears
|
DisGeNET Curated
|
6.100E-4
|
4.999E-3
|
2.908E-2
|
1.147E-1
|
2
|
55
|
20
|
cv:C3151113
|
Meier-Gorlin syndrome 3
|
Clinical Variations
|
6.788E-4
|
4.999E-3
|
2.908E-2
|
1.276E-1
|
1
|
1
|
21
|
C4021589
|
Absent glenoid fossa
|
DisGeNET Curated
|
6.788E-4
|
4.999E-3
|
2.908E-2
|
1.276E-1
|
1
|
1
|
22
|
C3151113
|
MEIER-GORLIN SYNDROME 3
|
DisGeNET Curated
|
6.788E-4
|
4.999E-3
|
2.908E-2
|
1.276E-1
|
1
|
1
|
23
|
cv:C0268181
|
Nonpersistence of intestinal lactase
|
Clinical Variations
|
6.788E-4
|
4.999E-3
|
2.908E-2
|
1.276E-1
|
1
|
1
|
24
|
cv:C1864947
|
Natural killer cell deficiency, familial isolated
|
Clinical Variations
|
6.788E-4
|
4.999E-3
|
2.908E-2
|
1.276E-1
|
1
|
1
|
25
|
cv:CN030358
|
Meier-Gorlin syndrome 1
|
Clinical Variations
|
6.788E-4
|
4.999E-3
|
2.908E-2
|
1.276E-1
|
1
|
1
|
26
|
C2053437
|
Full lower lip
|
DisGeNET Curated
|
8.254E-4
|
4.999E-3
|
2.908E-2
|
1.552E-1
|
2
|
64
|
27
|
C1839739
|
Prominent lower lip
|
DisGeNET Curated
|
8.254E-4
|
4.999E-3
|
2.908E-2
|
1.552E-1
|
2
|
64
|
28
|
C0240310
|
Hypoplasia of the maxilla
|
DisGeNET Curated
|
8.775E-4
|
4.999E-3
|
2.908E-2
|
1.650E-1
|
2
|
66
|
29
|
C4280643
|
Decreased projection of maxilla
|
DisGeNET Curated
|
8.775E-4
|
4.999E-3
|
2.908E-2
|
1.650E-1
|
2
|
66
|
30
|
C4082243
|
Maxillary retrognathia
|
DisGeNET Curated
|
8.775E-4
|
4.999E-3
|
2.908E-2
|
1.650E-1
|
2
|
66
|
31
|
C4280641
|
Hypotrophic maxilla
|
DisGeNET Curated
|
8.775E-4
|
4.999E-3
|
2.908E-2
|
1.650E-1
|
2
|
66
|
32
|
C4280640
|
Retrusion of upper jaw bones
|
DisGeNET Curated
|
8.775E-4
|
4.999E-3
|
2.908E-2
|
1.650E-1
|
2
|
66
|
33
|
C4280642
|
Deficiency of upper jaw bones
|
DisGeNET Curated
|
8.775E-4
|
4.999E-3
|
2.908E-2
|
1.650E-1
|
2
|
66
|
34
|
C0026034
|
Microstomia
|
DisGeNET Curated
|
1.223E-3
|
6.763E-3
|
3.933E-2
|
2.299E-1
|
2
|
78
|
35
|
C1855177
|
Flat glenoid fossa
|
DisGeNET Curated
|
1.357E-3
|
7.088E-3
|
4.122E-2
|
2.552E-1
|
1
|
2
|
36
|
C1864947
|
Natural Killer Cell Deficiency, Familial Isolated
|
DisGeNET Curated
|
1.357E-3
|
7.088E-3
|
4.122E-2
|
2.552E-1
|
1
|
2
|
37
|
C0424688
|
Small head
|
DisGeNET Curated
|
1.767E-3
|
8.976E-3
|
5.221E-2
|
3.321E-1
|
3
|
375
|
38
|
C4025857
|
Incomplete partition of the cochlea type II
|
DisGeNET Curated
|
2.035E-3
|
9.332E-3
|
5.428E-2
|
3.826E-1
|
1
|
3
|
39
|
C3697776
|
Proliferative verrucous oral leukoplakia
|
DisGeNET BeFree
|
2.035E-3
|
9.332E-3
|
5.428E-2
|
3.826E-1
|
1
|
3
|
40
|
C1859455
|
Small anterior fontanelle
|
DisGeNET Curated
|
2.035E-3
|
9.332E-3
|
5.428E-2
|
3.826E-1
|
1
|
3
|
41
|
C1857078
|
Mondini malformation
|
DisGeNET Curated
|
2.035E-3
|
9.332E-3
|
5.428E-2
|
3.826E-1
|
1
|
3
|
42
|
C0004135
|
Ataxia Telangiectasia
|
DisGeNET Curated
|
2.233E-3
|
9.995E-3
|
5.814E-2
|
4.198E-1
|
3
|
407
|
43
|
C1336084
|
Squamous Lung Dysplasia
|
DisGeNET BeFree
|
2.713E-3
|
1.186E-2
|
6.898E-2
|
5.100E-1
|
1
|
4
|
44
|
C0022951
|
Lactose Intolerance
|
DisGeNET Curated
|
3.390E-3
|
1.385E-2
|
8.058E-2
|
6.373E-1
|
1
|
5
|
45
|
C1969653
|
MUNGAN SYNDROME
|
DisGeNET Curated
|
3.390E-3
|
1.385E-2
|
8.058E-2
|
6.373E-1
|
1
|
5
|
46
|
C0426805
|
Hooked clavicle
|
DisGeNET Curated
|
3.390E-3
|
1.385E-2
|
8.058E-2
|
6.373E-1
|
1
|
5
|
47
|
C1266025
|
Traditional Serrated Adenoma
|
DisGeNET BeFree
|
3.503E-3
|
1.401E-2
|
8.150E-2
|
6.586E-1
|
2
|
133
|
48
|
C0541764
|
Delayed bone age
|
DisGeNET Curated
|
3.659E-3
|
1.433E-2
|
8.336E-2
|
6.880E-1
|
2
|
136
|
49
|
C0268540
|
HHH syndrome
|
DisGeNET Curated
|
4.067E-3
|
1.529E-2
|
8.893E-2
|
7.645E-1
|
1
|
6
|
50
|
C0423807
|
Overcurvature of nail
|
DisGeNET Curated
|
4.067E-3
|
1.529E-2
|
8.893E-2
|
7.645E-1
|
1
|
6
|
Show 45 more annotations
|
|