Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc250_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 47 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2.413E-20 1.134E-18 5.033E-18 1.134E-18 7 16
2 GO:0008094 DNA-dependent ATPase activity 4.558E-17 1.071E-15 4.754E-15 2.142E-15 8 93
3 GO:0042623 ATPase activity, coupled 1.454E-12 2.278E-11 1.011E-10 6.834E-11 8 332
4 GO:0016887 ATPase activity 1.550E-11 1.822E-10 8.085E-10 7.287E-10 8 446
5 GO:0004674 protein serine/threonine kinase activity 1.418E-9 1.332E-8 5.913E-8 6.662E-8 7 452
6 GO:0003678 DNA helicase activity 4.343E-8 3.402E-7 1.510E-6 2.041E-6 4 65
7 GO:0004386 helicase activity 2.187E-6 1.431E-5 6.351E-5 1.028E-4 4 172
8 GO:0004003 ATP-dependent DNA helicase activity 2.436E-6 1.431E-5 6.351E-5 1.145E-4 3 47
9 GO:0070035 purine NTP-dependent helicase activity 3.353E-5 1.576E-4 6.994E-4 1.576E-3 3 112
10 GO:0008026 ATP-dependent helicase activity 3.353E-5 1.576E-4 6.994E-4 1.576E-3 3 112
11 GO:0047485 protein N-terminus binding 3.821E-5 1.632E-4 7.245E-4 1.796E-3 3 117
12 GO:0097472 cyclin-dependent protein kinase activity 1.860E-4 6.724E-4 2.984E-3 8.741E-3 2 35
13 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1.860E-4 6.724E-4 2.984E-3 8.741E-3 2 35
14 GO:0008022 protein C-terminus binding 2.622E-4 8.804E-4 3.907E-3 1.233E-2 3 224
15 GO:0003684 damaged DNA binding 6.439E-4 2.018E-3 8.954E-3 3.026E-2 2 65
16 GO:0000404 heteroduplex DNA loop binding 1.179E-3 3.462E-3 1.537E-2
5.539E-2
 1 2
17 GO:0032564 dATP binding 2.356E-3 6.514E-3 2.891E-2
1.107E-1
 1 4
18 GO:0032558 adenyl deoxyribonucleotide binding 2.944E-3 7.688E-3 3.412E-2
1.384E-1
 1 5
19 GO:0032554 purine deoxyribonucleotide binding 3.532E-3 8.300E-3 3.684E-2
1.660E-1
 1 6
20 GO:0032135 DNA insertion or deletion binding 3.532E-3 8.300E-3 3.684E-2
1.660E-1
 1 6
21 GO:0000405 bubble DNA binding 4.120E-3 9.220E-3 4.092E-2
1.936E-1
 1 7
22 GO:0000182 rDNA binding 4.707E-3 9.618E-3 4.269E-2
2.212E-1
 1 8
23 GO:0032552 deoxyribonucleotide binding 4.707E-3 9.618E-3 4.269E-2
2.212E-1
 1 8
24 GO:0030983 mismatched DNA binding 7.053E-3 1.381E-2
6.130E-2
3.315E-1
 1 12
25 GO:0043138 3'-5' DNA helicase activity 7.638E-3 1.436E-2
6.373E-2
3.590E-1
 1 13
26 GO:0043139 5'-3' DNA helicase activity 1.115E-2 2.015E-2
8.942E-2
5.239E-1
 1 19
27 GO:0000217 DNA secondary structure binding 1.464E-2 2.549E-2
1.131E-1
6.882E-1
 1 25
28 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2.102E-2 3.529E-2
1.566E-1
9.881E-1
 1 36
29 GO:0050681 androgen receptor binding 2.391E-2 3.746E-2
1.662E-1
1.000E0
 1 41
30 GO:0051539 4 iron, 4 sulfur cluster binding 2.391E-2 3.746E-2
1.662E-1
1.000E0
 1 41
Show 25 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 173 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006294 nucleotide-excision repair, preincision complex assembly 7.419E-25 1.283E-22 7.358E-22 1.283E-22 9 29
2 GO:0006289 nucleotide-excision repair 8.439E-22 7.300E-20 4.185E-19 1.460E-19 10 119
3 GO:0006362 transcription elongation from RNA polymerase I promoter 3.621E-21 2.059E-19 1.180E-18 6.264E-19 8 31
4 GO:0006363 termination of RNA polymerase I transcription 4.827E-21 2.059E-19 1.180E-18 8.351E-19 8 32
5 GO:0006370 7-methylguanosine mRNA capping 6.371E-21 2.059E-19 1.180E-18 1.102E-18 8 33
6 GO:0006283 transcription-coupled nucleotide-excision repair 7.161E-21 2.059E-19 1.180E-18 1.239E-18 9 73
7 GO:0006361 transcription initiation from RNA polymerase I promoter 8.330E-21 2.059E-19 1.180E-18 1.441E-18 8 34
8 GO:0036260 RNA capping 2.242E-20 4.311E-19 2.471E-18 3.880E-18 8 38
9 GO:0009452 7-methylguanosine RNA capping 2.242E-20 4.311E-19 2.471E-18 3.880E-18 8 38
10 GO:0000717 nucleotide-excision repair, DNA duplex unwinding 3.645E-19 6.306E-18 3.615E-17 6.306E-17 7 22
11 GO:0006360 transcription by RNA polymerase I 1.346E-18 2.117E-17 1.214E-16 2.328E-16 8 61
12 GO:0070911 global genome nucleotide-excision repair 7.180E-18 1.035E-16 5.935E-16 1.242E-15 7 32
13 GO:0006368 transcription elongation from RNA polymerase II promoter 6.571E-17 8.745E-16 5.014E-15 1.137E-14 8 97
14 GO:0006353 DNA-templated transcription, termination 9.964E-17 1.231E-15 7.059E-15 1.724E-14 8 102
15 GO:0065004 protein-DNA complex assembly 2.517E-16 2.903E-15 1.664E-14 4.355E-14 9 225
16 GO:0006293 nucleotide-excision repair, preincision complex stabilization 4.316E-16 4.392E-15 2.518E-14 7.466E-14 6 21
17 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion 4.316E-16 4.392E-15 2.518E-14 7.466E-14 6 21
18 GO:0006354 DNA-templated transcription, elongation 5.326E-16 5.119E-15 2.935E-14 9.215E-14 8 125
19 GO:0071824 protein-DNA complex subunit organization 7.085E-16 6.451E-15 3.699E-14 1.226E-13 9 252
20 GO:0032508 DNA duplex unwinding 4.625E-15 4.001E-14 2.294E-13 8.002E-13 7 76
21 GO:0032392 DNA geometric change 7.350E-15 6.055E-14 3.471E-13 1.271E-12 7 81
22 GO:0006367 transcription initiation from RNA polymerase II promoter 8.339E-15 6.557E-14 3.760E-13 1.443E-12 8 175
23 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 1.842E-14 1.386E-13 7.944E-13 3.187E-12 6 37
24 GO:0033683 nucleotide-excision repair, DNA incision 2.584E-14 1.863E-13 1.068E-12 4.470E-12 6 39
25 GO:0006352 DNA-templated transcription, initiation 8.507E-14 5.887E-13 3.375E-12 1.472E-11 8 233
26 GO:0006397 mRNA processing 2.788E-11 1.855E-10 1.064E-9 4.823E-9 8 479
27 GO:0071103 DNA conformation change 5.721E-11 3.666E-10 2.102E-9 9.898E-9 7 285
28 GO:0031334 positive regulation of protein complex assembly 1.384E-9 8.552E-9 4.903E-8 2.395E-7 6 228
29 GO:0090305 nucleic acid phosphodiester bond hydrolysis 3.993E-9 2.382E-8 1.366E-7 6.907E-7 6 272
30 GO:0009411 response to UV 9.957E-9 5.742E-8 3.292E-7 1.723E-6 5 140
31 GO:0043254 regulation of protein complex assembly 3.990E-8 2.227E-7 1.277E-6 6.903E-6 6 400
32 GO:0044089 positive regulation of cellular component biogenesis 8.351E-8 4.515E-7 2.588E-6 1.445E-5 6 453
33 GO:0009314 response to radiation 1.177E-7 6.168E-7 3.537E-6 2.036E-5 6 480
34 GO:0009416 response to light stimulus 7.959E-7 4.050E-6 2.322E-5 1.377E-4 5 337
35 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 1.996E-5 9.864E-5 5.655E-4 3.452E-3 3 94
36 GO:0009650 UV protection 2.087E-5 1.003E-4 5.749E-4 3.610E-3 2 12
37 GO:1904029 regulation of cyclin-dependent protein kinase activity 2.331E-5 1.090E-4 6.249E-4 4.033E-3 3 99
38 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain 2.875E-5 1.309E-4 7.505E-4 4.974E-3 2 14
39 GO:0035315 hair cell differentiation 3.826E-4 1.697E-3 9.730E-3
6.619E-2
 2 50
40 GO:1901990 regulation of mitotic cell cycle phase transition 7.351E-4 3.179E-3 1.823E-2
1.272E-1
 3 318
41 GO:1901987 regulation of cell cycle phase transition 8.775E-4 3.703E-3 2.123E-2
1.518E-1
 3 338
42 GO:0032289 central nervous system myelin formation 1.771E-3 7.295E-3 4.183E-2
3.064E-1
 1 3
43 GO:0006979 response to oxidative stress 1.864E-3 7.501E-3 4.300E-2
3.225E-1
 3 439
44 GO:0010212 response to ionizing radiation 3.695E-3 1.453E-2
8.330E-2
6.392E-1
 2 157
45 GO:0071478 cellular response to radiation 4.416E-3 1.698E-2
9.733E-2
7.640E-1
 2 172
46 GO:0040016 embryonic cleavage 4.716E-3 1.774E-2
1.017E-1
8.159E-1
 1 8
47 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain 5.305E-3 1.912E-2
1.096E-1
9.177E-1
 1 9
48 GO:0006265 DNA topological change 5.305E-3 1.912E-2
1.096E-1
9.177E-1
 1 9
49 GO:0000086 G2/M transition of mitotic cell cycle 5.751E-3 1.970E-2
1.130E-1
9.949E-1
 2 197
50 GO:0070914 UV-damage excision repair 5.892E-3 1.970E-2
1.130E-1
1.000E0
 1 10
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 30 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005675 transcription factor TFIIH holo complex 3.122E-21 9.366E-20 3.742E-19 9.366E-20 7 13
2 GO:0032806 carboxy-terminal domain protein kinase complex 4.452E-19 5.827E-18 2.328E-17 1.336E-17 7 23
3 GO:0000439 transcription factor TFIIH core complex 5.827E-19 5.827E-18 2.328E-17 1.748E-17 6 9
4 GO:1902554 serine/threonine protein kinase complex 6.248E-15 4.686E-14 1.872E-13 1.874E-13 7 81
5 GO:1902911 protein kinase complex 1.571E-14 9.425E-14 3.765E-13 4.713E-13 7 92
6 GO:0016591 RNA polymerase II, holoenzyme 2.478E-14 1.239E-13 4.950E-13 7.434E-13 7 98
7 GO:0090575 RNA polymerase II transcription factor complex 4.071E-14 1.745E-13 6.971E-13 1.221E-12 7 105
8 GO:0055029 nuclear DNA-directed RNA polymerase complex 1.126E-13 3.754E-13 1.500E-12 3.378E-12 7 121
9 GO:0000428 DNA-directed RNA polymerase complex 1.126E-13 3.754E-13 1.500E-12 3.378E-12 7 121
10 GO:0030880 RNA polymerase complex 1.342E-13 4.025E-13 1.608E-12 4.025E-12 7 124
11 GO:0044798 nuclear transcription factor complex 2.335E-13 6.369E-13 2.544E-12 7.006E-12 7 134
12 GO:0061695 transferase complex, transferring phosphorus-containing groups 1.633E-11 4.082E-11 1.631E-10 4.899E-10 7 244
13 GO:0005667 transcription factor complex 2.917E-10 6.732E-10 2.689E-9 8.751E-9 7 368
14 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex 4.536E-6 9.720E-6 3.883E-5 1.361E-4 2 6
15 GO:0000109 nucleotide-excision repair complex 2.745E-5 5.490E-5 2.193E-4 8.235E-4 2 14
16 GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex 3.166E-5 5.937E-5 2.372E-4 9.499E-4 2 15
17 GO:0000307 cyclin-dependent protein kinase holoenzyme complex 1.488E-4 2.625E-4 1.049E-3 4.463E-3 2 32
18 GO:1990391 DNA repair complex 3.091E-4 5.151E-4 2.058E-3 9.272E-3 2 46
19 GO:0070985 transcription factor TFIIK complex 5.771E-4 8.656E-4 3.458E-3 1.731E-2 1 1
20 GO:0000111 nucleotide-excision repair factor 2 complex 5.771E-4 8.656E-4 3.458E-3 1.731E-2 1 1
21 GO:0071942 XPC complex 1.730E-3 2.472E-3 9.875E-3
5.191E-2
 1 3
22 GO:0071817 MMXD complex 2.882E-3 3.931E-3 1.570E-2
8.647E-2
 1 5
23 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 5.183E-3 6.760E-3 2.701E-2
1.555E-1
 1 9
24 GO:0080008 Cul4-RING E3 ubiquitin ligase complex 1.434E-2 1.792E-2
7.159E-2
4.301E-1
 1 25
Show 19 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 433 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001480 Freckling 2.688E-12 1.164E-9 7.739E-9 1.164E-9 6 58
2 HP:0004334 Dermal atrophy 5.062E-11 1.096E-8 7.287E-8 2.192E-8 6 93
3 HP:0000992 Cutaneous photosensitivity 2.552E-10 3.684E-8 2.450E-7 1.105E-7 6 121
4 HP:0002299 Brittle hair 6.564E-10 7.105E-8 4.724E-7 2.842E-7 5 50
5 HP:0000958 Dry skin 8.748E-10 7.576E-8 5.037E-7 3.788E-7 6 148
6 HP:0008065 Aplasia/Hypoplasia of the skin 1.518E-9 1.096E-7 7.285E-7 6.574E-7 6 162
7 HP:0007479 Congenital nonbullous ichthyosiform erythroderma 2.832E-9 1.752E-7 1.165E-6 1.226E-6 4 19
8 HP:0008887 Adipose tissue loss 5.339E-9 2.890E-7 1.921E-6 2.312E-6 4 22
9 HP:0002671 Basal cell carcinoma 1.137E-8 5.471E-7 3.637E-6 4.924E-6 5 87
10 HP:0010719 Abnormality of hair texture 1.785E-8 7.526E-7 5.004E-6 7.727E-6 6 243
11 HP:0003328 Abnormal hair laboratory examination 1.995E-8 7.526E-7 5.004E-6 8.637E-6 4 30
12 HP:0000491 Keratitis 2.086E-8 7.526E-7 5.004E-6 9.031E-6 5 98
13 HP:0002213 Fine hair 2.686E-8 8.947E-7 5.949E-6 1.163E-5 5 103
14 HP:0007431 Congenital ichthyosiform erythroderma 3.804E-8 1.177E-6 7.824E-6 1.647E-5 4 35
15 HP:0040063 Decreased adipose tissue 4.795E-8 1.298E-6 8.629E-6 2.076E-5 4 37
16 HP:0003758 Reduced subcutaneous adipose tissue 4.795E-8 1.298E-6 8.629E-6 2.076E-5 4 37
17 HP:0007606 Multiple cutaneous malignancies 6.432E-8 1.547E-6 1.029E-5 2.785E-5 3 8
18 HP:0010649 Flat nasal alae 6.432E-8 1.547E-6 1.029E-5 2.785E-5 3 8
19 HP:0011495 Abnormal corneal epithelium morphology 1.465E-7 3.285E-6 2.184E-5 6.344E-5 5 144
20 HP:0000502 Abnormal conjunctiva morphology 1.517E-7 3.285E-6 2.184E-5 6.569E-5 5 145
21 HP:0009886 Trichorrhexis nodosa 1.893E-7 3.727E-6 2.478E-5 8.195E-5 3 11
22 HP:0000135 Hypogonadism 1.893E-7 3.727E-6 2.478E-5 8.199E-5 6 359
23 HP:0007485 Absence of subcutaneous fat 2.522E-7 4.748E-6 3.157E-5 1.092E-4 3 12
24 HP:0001001 Abnormality of subcutaneous fat tissue 3.058E-7 5.518E-6 3.669E-5 1.324E-4 4 58
25 HP:0009755 Ankyloblepharon 3.277E-7 5.676E-6 3.774E-5 1.419E-4 3 13
26 HP:0007537 Severe photosensitivity 7.777E-7 1.289E-5 8.568E-5 3.368E-4 3 17
27 HP:0008064 Ichthyosis 8.036E-7 1.289E-5 8.568E-5 3.479E-4 5 202
28 HP:0002115 Sparse or absent hair 9.264E-7 1.433E-5 9.526E-5 4.011E-4 6 467
29 HP:0000613 Photophobia 1.410E-6 2.105E-5 1.400E-4 6.105E-4 5 226
30 HP:0000621 Entropion 1.757E-6 2.498E-5 1.661E-4 7.608E-4 3 22
31 HP:0002860 Squamous cell carcinoma 1.788E-6 2.498E-5 1.661E-4 7.743E-4 5 237
32 HP:0000524 Conjunctival telangiectasia 2.020E-6 2.650E-5 1.762E-4 8.745E-4 3 23
33 HP:0001808 Fragile nails 2.020E-6 2.650E-5 1.762E-4 8.745E-4 3 23
34 HP:0007759 Opacification of the corneal stroma 2.171E-6 2.765E-5 1.839E-4 9.402E-4 4 94
35 HP:0011492 Abnormality of corneal stroma 2.364E-6 2.924E-5 1.944E-4 1.023E-3 4 96
36 HP:0008054 Abnormal vasculature of the conjunctiva morphology 2.620E-6 3.152E-5 2.096E-4 1.135E-3 3 25
37 HP:0100533 Inflammatory abnormality of the eye 2.951E-6 3.350E-5 2.227E-4 1.278E-3 5 262
38 HP:0025337 Red eye 3.017E-6 3.350E-5 2.227E-4 1.307E-3 4 102
39 HP:0000509 Conjunctivitis 3.017E-6 3.350E-5 2.227E-4 1.307E-3 4 102
40 HP:0001029 Poikiloderma 3.329E-6 3.516E-5 2.338E-4 1.442E-3 3 27
41 HP:0006739 Squamous cell carcinoma of the skin 3.329E-6 3.516E-5 2.338E-4 1.442E-3 3 27
42 HP:0045055 Tiger tail banding 4.061E-6 4.186E-5 2.784E-4 1.758E-3 2 3
43 HP:0004493 Craniofacial hyperostosis 5.107E-6 5.142E-5 3.419E-4 2.211E-3 3 31
44 HP:0001059 Pterygium 5.632E-6 5.419E-5 3.603E-4 2.439E-3 3 32
45 HP:0011133 Increased sensitivity to ionizing radiation 5.632E-6 5.419E-5 3.603E-4 2.439E-3 3 32
46 HP:0003254 Abnormality of DNA repair 6.788E-6 6.289E-5 4.182E-4 2.939E-3 3 34
47 HP:0003510 Severe short stature 6.827E-6 6.289E-5 4.182E-4 2.956E-3 4 125
48 HP:0007587 Numerous pigmented freckles 8.117E-6 7.173E-5 4.769E-4 3.515E-3 2 4
49 HP:0003224 Increased cellular sensitivity to UV light 8.117E-6 7.173E-5 4.769E-4 3.515E-3 2 4
50 HP:0100579 Mucosal telangiectasiae 1.034E-5 8.957E-5 5.955E-4 4.478E-3 3 39
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 8 input genes in category / 253 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008410 increased cellular sensitivity to ultraviolet irradiation 4.562E-9 1.154E-6 7.055E-6 1.154E-6 4 31
2 MP:0004501 increased incidence of tumors by UV-induction 1.371E-7 1.735E-5 1.060E-4 3.469E-5 3 15
3 MP:0008943 increased sensitivity to induced cell death 6.118E-6 5.159E-4 3.154E-3 1.548E-3 4 182
4 MP:0001202 skin photosensitivity 1.095E-5 6.924E-4 4.232E-3 2.770E-3 2 7
5 MP:0003786 premature aging 1.761E-5 8.909E-4 5.446E-3 4.454E-3 3 72
6 MP:0008942 abnormal induced cell death 2.326E-5 9.809E-4 5.996E-3 5.885E-3 4 255
7 MP:0001999 photosensitivity 3.434E-5 1.241E-3 7.587E-3 8.688E-3 2 12
8 MP:0001203 increased sensitivity to skin irradiation 4.057E-5 1.283E-3 7.842E-3 1.026E-2 2 13
9 MP:0008058 abnormal DNA repair 9.201E-5 2.429E-3 1.485E-2 2.328E-2 3 125
10 MP:0001216 abnormal epidermal layer morphology 9.601E-5 2.429E-3 1.485E-2 2.429E-2 4 366
11 MP:0001263 weight loss 1.896E-4 4.113E-3 2.514E-2 4.797E-2 4 436
12 MP:0005150 cachexia 1.951E-4 4.113E-3 2.514E-2 4.936E-2 3 161
13 MP:0002021 increased incidence of induced tumors 2.136E-4 4.156E-3 2.541E-2
5.403E-2
 3 166
14 MP:0001874 acanthosis 5.315E-4 8.614E-3
5.265E-2
1.345E-1
 2 46
15 MP:0008412 increased cellular sensitivity to oxidative stress 5.315E-4 8.614E-3
5.265E-2
1.345E-1
 2 46
16 MP:0000160 kyphosis 5.721E-4 8.614E-3
5.265E-2
1.447E-1
 3 232
17 MP:0009611 epidermis stratum spinosum hyperplasia 5.788E-4 8.614E-3
5.265E-2
1.464E-1
 2 48
18 MP:0000377 abnormal hair follicle morphology 6.317E-4 8.879E-3
5.427E-2
1.598E-1
 3 240
19 MP:0013151 abnormal incidence of induced tumors 7.118E-4 9.308E-3
5.689E-2
1.801E-1
 3 250
20 MP:0002007 increased cellular sensitivity to gamma-irradiation 7.599E-4 9.308E-3
5.689E-2
1.923E-1
 2 55
21 MP:0009613 thin epidermis suprabasal layer 7.726E-4 9.308E-3
5.689E-2
1.955E-1
 1 1
22 MP:0001191 abnormal skin condition 8.718E-4 1.003E-2
6.128E-2
2.206E-1
 3 268
23 MP:0002427 disproportionate dwarf 9.343E-4 1.028E-2
6.282E-2
2.364E-1
 2 61
24 MP:0030572 abnormal pilosebaceous unit morphology 1.187E-3 1.251E-2
7.647E-2
3.002E-1
 3 298
25 MP:0008918 microgliosis 1.264E-3 1.279E-2
7.818E-2
3.197E-1
 2 71
26 MP:0001192 scaly skin 1.485E-3 1.376E-2
8.412E-2
3.756E-1
 2 77
27 MP:0004174 abnormal spine curvature 1.512E-3 1.376E-2
8.412E-2
3.825E-1
 3 324
28 MP:0001236 abnormal epidermis stratum spinosum morphology 1.523E-3 1.376E-2
8.412E-2
3.853E-1
 2 78
29 MP:0004227 increased cellular sensitivity to ionizing radiation 1.682E-3 1.441E-2
8.806E-2
4.255E-1
 2 82
30 MP:0001393 ataxia 1.708E-3 1.441E-2
8.806E-2
4.322E-1
 3 338
31 MP:0005501 abnormal skin physiology 2.098E-3 1.712E-2
1.047E-1
5.308E-1
 3 363
32 MP:0000416 sparse hair 2.392E-3 1.891E-2
1.156E-1
6.052E-1
 2 98
33 MP:0000136 abnormal microglial cell morphology 2.639E-3 2.023E-2
1.237E-1
6.676E-1
 2 103
34 MP:0001222 epidermal hyperplasia 2.792E-3 2.078E-2
1.270E-1
7.064E-1
 2 106
35 MP:0004016 decreased bone mass 2.897E-3 2.094E-2
1.280E-1
7.329E-1
 2 108
36 MP:0013787 photophobia 3.087E-3 2.170E-2
1.326E-1
7.811E-1
 1 4
37 MP:0003354 astrocytosis 4.168E-3 2.850E-2
1.742E-1
1.000E0
 2 130
38 MP:0001406 abnormal gait 4.306E-3 2.867E-2
1.753E-1
1.000E0
 3 467
39 MP:0012065 increased astrocyte number 4.552E-3 2.891E-2
1.767E-1
1.000E0
 2 136
40 MP:0002879 increased cellular sensitivity to X-ray irradiation 4.628E-3 2.891E-2
1.767E-1
1.000E0
 1 6
41 MP:0012064 abnormal astrocyte number 4.684E-3 2.891E-2
1.767E-1
1.000E0
 2 138
42 MP:0001525 impaired balance 5.299E-3 3.175E-2
1.941E-1
1.000E0
 2 147
43 MP:0000381 enlarged hair follicles 5.397E-3 3.175E-2
1.941E-1
1.000E0
 1 7
44 MP:0000414 alopecia 5.729E-3 3.294E-2
2.013E-1
1.000E0
 2 153
45 MP:0010202 focal dorsal hair loss 6.934E-3 3.733E-2
2.282E-1
1.000E0
 1 9
46 MP:0011705 absent fibroblast proliferation 6.934E-3 3.733E-2
2.282E-1
1.000E0
 1 9
47 MP:0003848 brittle hair 6.934E-3 3.733E-2
2.282E-1
1.000E0
 1 9
48 MP:0010699 dilated hair follicles 7.702E-3 3.977E-2
2.431E-1
1.000E0
 1 10
49 MP:0009796 abnormal base-excision repair 7.702E-3 3.977E-2
2.431E-1
1.000E0
 1 10
50 MP:0002182 abnormal astrocyte morphology 9.534E-3 4.824E-2
2.949E-1
1.000E0
 2 199
Show 45 more annotations

6: Domain [Display Chart] 11 input genes in category / 100 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM01032 BHD 3 SMART 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
2 PF03849 Tfb2 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
3 IPR032830 XPB/Ssl2 N InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
4 PF03835 Rad4 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
5 PF06331 Tfb5 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
6 SM01030 BHD 1 SMART 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
7 PF06777 HBB Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
8 IPR010643 HBB InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
9 PF10404 BHD 2 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
10 IPR018026 DNA repair Rad4 subgr InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
11 PF15502 MPLKIP Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
12 IPR001945 RAD3/XPD InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
13 IPR018327 BHD 2 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
14 IPR004583 DNA repair Rad4 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
15 IPR009400 TFIIH TTDA/Tfb5 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
16 IPR004598 TFIIH p52/Tfb2 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
17 SM01031 BHD 2 SMART 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
18 PF13625 Helicase C 3 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
19 3.30.70.1220 - Gene3D 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
20 IPR026618 MPLKIP-like vertebrate InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
21 IPR018325 Rad4/PNGase transGLS-fold InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
22 PF16203 ERCC3 RAD25 C Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
23 IPR032438 ERCC3 RAD25 C InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
24 PF08567 PH TFIIH Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
25 IPR018326 Rad4 beta-hairpin dom1 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
26 PF10405 BHD 3 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
27 IPR028265 MPLKIP-like InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
28 PF10403 BHD 1 Pfam 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
29 SM01395 Tbf5 SMART 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
30 IPR027079 Tfb1/p62 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
31 IPR027081 CyclinH/Ccl1 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
32 IPR018328 Rad4 beta-hairpin dom3 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
33 IPR001161 XPB/Ssl2 InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
34 IPR013876 TFIIH BTF p62 N InterPro 5.871E-4 1.727E-3 8.958E-3
5.871E-2
 1 1
35 IPR012170 TFIIH SSL1/p44 InterPro 1.174E-3 2.935E-3 1.522E-2
1.174E-1
 1 2
36 IPR004595 TFIIH C1-like dom InterPro 1.174E-3 2.935E-3 1.522E-2
1.174E-1
 1 2
37 IPR031658 Cyclin C 2 InterPro 1.174E-3 2.935E-3 1.522E-2
1.174E-1
 1 2
38 SM01047 C1 4 SMART 1.174E-3 2.935E-3 1.522E-2
1.174E-1
 1 2
39 PF16899 Cyclin C 2 Pfam 1.174E-3 2.935E-3 1.522E-2
1.174E-1
 1 2
40 PF07975 C1 4 Pfam 1.174E-3 2.935E-3 1.522E-2
1.174E-1
 1 2
41 PF03909 BSD Pfam 1.760E-3 3.827E-3 1.985E-2
1.760E-1
 1 3
42 PS50858 BSD PROSITE 1.760E-3 3.827E-3 1.985E-2
1.760E-1
 1 3
43 SM00751 BSD SMART 1.760E-3 3.827E-3 1.985E-2
1.760E-1
 1 3
44 IPR007198 Ssl1-like InterPro 1.760E-3 3.827E-3 1.985E-2
1.760E-1
 1 3
45 PF04056 Ssl1 Pfam 1.760E-3 3.827E-3 1.985E-2
1.760E-1
 1 3
46 IPR005607 BSD dom InterPro 1.760E-3 3.827E-3 1.985E-2
1.760E-1
 1 3
47 PF13307 Helicase C 2 Pfam 2.347E-3 4.190E-3 2.174E-2
2.347E-1
 1 4
48 SM00491 HELICc2 SMART 2.347E-3 4.190E-3 2.174E-2
2.347E-1
 1 4
49 IPR014013 Helic SF1/SF2 ATP-bd DinG/Rad3 InterPro 2.347E-3 4.190E-3 2.174E-2
2.347E-1
 1 4
50 IPR006555 ATP-dep Helicase C InterPro 2.347E-3 4.190E-3 2.174E-2
2.347E-1
 1 4
Show 45 more annotations

7: Pathway [Display Chart] 10 input genes in category / 75 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83044 Nucleotide excision repair BioSystems: KEGG 2.108E-25 1.581E-23 7.748E-23 1.581E-23 10 47
2 1309114 Formation of Incision Complex in GG-NER BioSystems: REACTOME 2.849E-22 1.068E-20 5.236E-20 2.137E-20 9 43
3 1309111 Nucleotide Excision Repair BioSystems: REACTOME 2.304E-21 5.033E-20 2.467E-19 1.728E-19 10 112
4 1309118 Formation of TC-NER Pre-Incision Complex BioSystems: REACTOME 2.684E-21 5.033E-20 2.467E-19 2.013E-19 9 54
5 1269073 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection BioSystems: REACTOME 6.975E-21 8.719E-20 4.273E-19 5.231E-19 8 27
6 1269681 RNA Pol II CTD phosphorylation and interaction with CE BioSystems: REACTOME 6.975E-21 8.719E-20 4.273E-19 5.231E-19 8 27
7 1269687 mRNA Capping BioSystems: REACTOME 1.348E-20 1.444E-19 7.080E-19 1.011E-18 8 29
8 1309120 Gap-filling DNA repair synthesis and ligation in TC-NER BioSystems: REACTOME 1.612E-20 1.511E-19 7.408E-19 1.209E-18 9 65
9 1309119 Dual incision in TC-NER BioSystems: REACTOME 1.867E-20 1.556E-19 7.624E-19 1.400E-18 9 66
10 1269661 RNA Polymerase I Promoter Escape BioSystems: REACTOME 2.477E-20 1.858E-19 9.106E-19 1.858E-18 8 31
11 1269663 RNA Polymerase I Transcription Termination BioSystems: REACTOME 3.302E-20 2.252E-19 1.104E-18 2.477E-18 8 32
12 1269075 Formation of the HIV-1 Early Elongation Complex BioSystems: REACTOME 7.386E-20 4.261E-19 2.089E-18 5.539E-18 8 35
13 1269683 Formation of the Early Elongation Complex BioSystems: REACTOME 7.386E-20 4.261E-19 2.089E-18 5.539E-18 8 35
14 1309117 Transcription-Coupled Nucleotide Excision Repair (TC-NER) BioSystems: REACTOME 1.037E-19 5.555E-19 2.723E-18 7.777E-18 9 79
15 1309112 Global Genome Nucleotide Excision Repair (GG-NER) BioSystems: REACTOME 2.074E-19 1.037E-18 5.082E-18 1.555E-17 9 85
16 83038 Basal transcription factors BioSystems: KEGG 6.755E-19 3.166E-18 1.552E-17 5.066E-17 8 45
17 1269680 RNA Polymerase II Promoter Escape BioSystems: REACTOME 9.851E-19 3.358E-18 1.646E-17 7.388E-17 8 47
18 1269677 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening BioSystems: REACTOME 9.851E-19 3.358E-18 1.646E-17 7.388E-17 8 47
19 1269071 HIV Transcription Initiation BioSystems: REACTOME 9.851E-19 3.358E-18 1.646E-17 7.388E-17 8 47
20 1269072 RNA Polymerase II HIV Promoter Escape BioSystems: REACTOME 9.851E-19 3.358E-18 1.646E-17 7.388E-17 8 47
21 1269678 RNA Polymerase II Transcription Initiation And Promoter Clearance BioSystems: REACTOME 9.851E-19 3.358E-18 1.646E-17 7.388E-17 8 47
22 1269679 RNA Polymerase II Transcription Initiation BioSystems: REACTOME 9.851E-19 3.358E-18 1.646E-17 7.388E-17 8 47
23 1269660 RNA Polymerase I Transcription Initiation BioSystems: REACTOME 1.182E-18 3.854E-18 1.889E-17 8.865E-17 8 48
24 1269076 Tat-mediated elongation of the HIV-1 transcript BioSystems: REACTOME 2.356E-18 6.796E-18 3.331E-17 1.767E-16 8 52
25 1269074 HIV Transcription Elongation BioSystems: REACTOME 2.356E-18 6.796E-18 3.331E-17 1.767E-16 8 52
26 1269077 Formation of HIV-1 elongation complex containing HIV-1 Tat BioSystems: REACTOME 2.356E-18 6.796E-18 3.331E-17 1.767E-16 8 52
27 1269080 Formation of HIV elongation complex in the absence of HIV Tat BioSystems: REACTOME 3.256E-18 9.045E-18 4.433E-17 2.442E-16 8 54
28 1269682 RNA Polymerase II Transcription Elongation BioSystems: REACTOME 2.037E-17 5.269E-17 2.583E-16 1.528E-15 8 67
29 1269684 Formation of RNA Pol II elongation complex BioSystems: REACTOME 2.037E-17 5.269E-17 2.583E-16 1.528E-15 8 67
30 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 3.736E-17 9.341E-17 4.578E-16 2.802E-15 8 72
31 1269070 Transcription of the HIV genome BioSystems: REACTOME 8.136E-17 1.968E-16 9.647E-16 6.102E-15 8 79
32 1270350 DNA Repair BioSystems: REACTOME 1.061E-16 2.488E-16 1.219E-15 7.961E-15 10 319
33 1269676 RNA Polymerase II Pre-transcription Events BioSystems: REACTOME 2.413E-16 5.485E-16 2.688E-15 1.810E-14 8 90
34 1269662 RNA Polymerase I Chain Elongation BioSystems: REACTOME 2.897E-16 6.391E-16 3.132E-15 2.173E-14 8 92
35 1269739 NoRC negatively regulates rRNA expression BioSystems: REACTOME 1.093E-15 2.343E-15 1.148E-14 8.199E-14 8 108
36 1269737 Negative epigenetic regulation of rRNA expression BioSystems: REACTOME 1.371E-15 2.778E-15 1.362E-14 1.028E-13 8 111
37 1269658 RNA Polymerase I Promoter Clearance BioSystems: REACTOME 1.371E-15 2.778E-15 1.362E-14 1.028E-13 8 111
38 1269657 RNA Polymerase I Transcription BioSystems: REACTOME 1.588E-15 3.134E-15 1.536E-14 1.191E-13 8 113
39 1269069 Late Phase of HIV Life Cycle BioSystems: REACTOME 9.783E-15 1.881E-14 9.221E-14 7.337E-13 8 141
40 1269656 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription BioSystems: REACTOME 1.713E-14 3.212E-14 1.575E-13 1.285E-12 8 151
41 1269734 Epigenetic regulation of gene expression BioSystems: REACTOME 1.808E-14 3.308E-14 1.621E-13 1.356E-12 8 152
42 1269058 HIV Life Cycle BioSystems: REACTOME 2.012E-14 3.593E-14 1.761E-13 1.509E-12 8 154
43 1269675 RNA Polymerase II Transcription BioSystems: REACTOME 3.042E-14 5.305E-14 2.600E-13 2.281E-12 8 162
44 1309115 Dual Incision in GG-NER BioSystems: REACTOME 1.810E-13 3.086E-13 1.512E-12 1.358E-11 6 41
45 1269057 HIV Infection BioSystems: REACTOME 7.393E-13 1.232E-12 6.039E-12 5.545E-11 8 240
46 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 2.631E-11 4.289E-11 2.102E-10 1.973E-9 8 374
47 1269056 Infectious disease BioSystems: REACTOME 3.914E-11 6.246E-11 3.061E-10 2.935E-9 8 393
48 M13022 Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle MSigDB C2 BIOCARTA (v6.0) 3.181E-5 4.971E-5 2.436E-4 2.386E-3 2 11
49 1269800 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 1.330E-4 2.036E-4 9.977E-4 9.974E-3 2 22
50 M17770 Cyclins and Cell Cycle Regulation MSigDB C2 BIOCARTA (v6.0) 1.456E-4 2.184E-4 1.070E-3 1.092E-2 2 23
Show 45 more annotations

8: Pubmed [Display Chart] 11 input genes in category / 1538 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26340423 Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Pubmed 6.616E-29 5.088E-26 4.027E-25 1.018E-25 8 10
2 15220921 A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. Pubmed 6.616E-29 5.088E-26 4.027E-25 1.018E-25 8 10
3 11062469 Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder. Pubmed 1.404E-26 7.197E-24 5.697E-23 2.159E-23 7 7
4 11313499 Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Pubmed 1.891E-26 7.273E-24 5.757E-23 2.909E-23 8 16
5 10214908 DNA damage recognition during nucleotide excision repair in mammalian cells. Pubmed 1.851E-25 5.693E-23 4.506E-22 2.847E-22 8 20
6 9130708 Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. Pubmed 5.053E-25 1.295E-22 1.025E-21 7.771E-22 7 9
7 10583946 Quality control by DNA repair. Pubmed 4.564E-24 7.913E-22 6.264E-21 7.019E-21 8 28
8 8628270 Three functional classes of transcriptional activation domain. Pubmed 4.631E-24 7.913E-22 6.264E-21 7.122E-21 7 11
9 10082552 Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase. Pubmed 4.631E-24 7.913E-22 6.264E-21 7.122E-21 7 11
10 8692842 Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. Pubmed 1.111E-23 1.563E-21 1.238E-20 1.709E-20 7 12
11 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 1.118E-23 1.563E-21 1.238E-20 1.720E-20 9 73
12 12646563 Rrn3 becomes inactivated in the process of ribosomal DNA transcription. Pubmed 7.066E-22 9.056E-20 7.168E-19 1.087E-18 7 19
13 9334327 The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Pubmed 1.630E-21 1.791E-19 1.418E-18 2.507E-18 7 21
14 9852112 Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. Pubmed 1.630E-21 1.791E-19 1.418E-18 2.507E-18 7 21
15 9582279 Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. Pubmed 2.391E-21 2.451E-19 1.940E-18 3.677E-18 7 22
16 9118947 Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. Pubmed 3.001E-21 2.517E-19 1.992E-18 4.616E-18 6 8
17 10438593 Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation. Pubmed 3.436E-21 2.517E-19 1.992E-18 5.285E-18 7 23
18 9570510 Tat, Tat-associated kinase, and transcription. Pubmed 3.436E-21 2.517E-19 1.992E-18 5.285E-18 7 23
19 10866664 Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Pubmed 3.436E-21 2.517E-19 1.992E-18 5.285E-18 7 23
20 9311822 A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity. Pubmed 3.436E-21 2.517E-19 1.992E-18 5.285E-18 7 23
21 9651670 Transcriptional control: Tat cofactors and transcriptional elongation. Pubmed 3.436E-21 2.517E-19 1.992E-18 5.285E-18 7 23
22 10066804 Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes. Pubmed 4.851E-21 3.109E-19 2.461E-18 7.461E-18 7 24
23 12393749 Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. Pubmed 4.851E-21 3.109E-19 2.461E-18 7.461E-18 7 24
24 14569024 The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA. Pubmed 4.851E-21 3.109E-19 2.461E-18 7.461E-18 7 24
25 9790902 Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Pubmed 6.737E-21 3.700E-19 2.929E-18 1.036E-17 7 25
26 9512541 Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. Pubmed 6.737E-21 3.700E-19 2.929E-18 1.036E-17 7 25
27 9184228 Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. Pubmed 6.737E-21 3.700E-19 2.929E-18 1.036E-17 7 25
28 8934526 Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Pubmed 6.737E-21 3.700E-19 2.929E-18 1.036E-17 7 25
29 8692841 Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH. Pubmed 2.250E-20 1.194E-18 9.448E-18 3.461E-17 6 10
30 9765201 The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. Pubmed 7.533E-20 3.862E-18 3.057E-17 1.159E-16 7 34
31 8946909 The general transcription factors of RNA polymerase II. Pubmed 2.153E-19 1.003E-17 7.942E-17 3.311E-16 7 39
32 9121429 The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. Pubmed 2.153E-19 1.003E-17 7.942E-17 3.311E-16 7 39
33 9405375 Three transitions in the RNA polymerase II transcription complex during initiation. Pubmed 2.153E-19 1.003E-17 7.942E-17 3.311E-16 7 39
34 9054383 Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. Pubmed 2.609E-19 1.115E-17 8.824E-17 4.013E-16 7 40
35 2449431 ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis. Pubmed 2.609E-19 1.115E-17 8.824E-17 4.013E-16 7 40
36 1939271 Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter. Pubmed 2.609E-19 1.115E-17 8.824E-17 4.013E-16 7 40
37 8849451 Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. Pubmed 1.030E-18 4.280E-17 3.388E-16 1.584E-15 7 48
38 28977422 The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH. Pubmed 4.094E-18 1.657E-16 1.312E-15 6.296E-15 5 6
39 21157430 The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. Pubmed 3.150E-16 1.242E-14 9.833E-14 4.845E-13 5 11
40 27193682 Near-atomic resolution visualization of human transcription promoter opening. Pubmed 1.364E-15 5.246E-14 4.153E-13 2.099E-12 5 14
41 16669699 Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. Pubmed 3.723E-15 1.332E-13 1.054E-12 5.726E-12 4 4
42 14980221 TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Pubmed 3.723E-15 1.332E-13 1.054E-12 5.726E-12 4 4
43 19172752 Structural basis for group A trichothiodystrophy. Pubmed 3.723E-15 1.332E-13 1.054E-12 5.726E-12 4 4
44 22902626 KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). Pubmed 4.216E-15 1.474E-13 1.166E-12 6.484E-12 5 17
45 10024882 Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. Pubmed 1.861E-14 6.090E-13 4.821E-12 2.862E-11 4 5
46 8612585 Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations. Pubmed 1.861E-14 6.090E-13 4.821E-12 2.862E-11 4 5
47 8521393 Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. Pubmed 1.861E-14 6.090E-13 4.821E-12 2.862E-11 4 5
48 12080057 p52 Mediates XPB function within the transcription/repair factor TFIIH. Pubmed 5.582E-14 1.789E-12 1.416E-11 8.586E-11 4 6
49 8652557 Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Pubmed 2.604E-13 8.175E-12 6.471E-11 4.006E-10 4 8
50 11259578 Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Pubmed 1.227E-12 3.775E-11 2.988E-10 1.887E-9 4 11
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 351 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GTF2H2 GTF2H2 interactions 3.653E-25 1.282E-22 8.256E-22 1.282E-22 9 26
2 int:GTF2H5 GTF2H5 interactions 5.212E-23 9.147E-21 5.890E-20 1.829E-20 8 19
3 int:ERCC3 ERCC3 interactions 5.737E-21 6.712E-19 4.322E-18 2.014E-18 9 68
4 int:GTF2H1 GTF2H1 interactions 1.130E-20 9.912E-19 6.382E-18 3.965E-18 9 73
5 int:CDK7 CDK7 interactions 5.959E-20 4.183E-18 2.694E-17 2.092E-17 9 87
6 int:GTF2H3 GTF2H3 interactions 2.363E-19 1.382E-17 8.901E-17 8.293E-17 7 20
7 int:CCNH CCNH interactions 9.741E-19 4.884E-17 3.145E-16 3.419E-16 8 56
8 int:MNAT1 MNAT1 interactions 3.457E-18 1.517E-16 9.766E-16 1.213E-15 8 65
9 int:ERCC5 ERCC5 interactions 4.749E-18 1.852E-16 1.193E-15 1.667E-15 7 29
10 int:GTF2H2C 2 GTF2H2C 2 interactions 5.402E-17 1.806E-15 1.163E-14 1.896E-14 6 15
11 int:ERCC2 ERCC2 interactions 5.660E-17 1.806E-15 1.163E-14 1.987E-14 7 40
12 int:GTF2H4 GTF2H4 interactions 8.000E-16 2.340E-14 1.507E-13 2.808E-13 7 57
13 int:UVSSA UVSSA interactions 2.723E-13 7.353E-12 4.735E-11 9.559E-11 5 18
14 int:ATF7IP ATF7IP interactions 1.802E-9 4.518E-8 2.909E-7 6.325E-7 5 95
15 int:AR AR interactions 1.682E-8 3.935E-7 2.534E-6 5.903E-6 6 329
16 int:POLR2A POLR2A interactions 1.807E-8 3.965E-7 2.553E-6 6.344E-6 6 333
17 int:GTF2H2C GTF2H2C interactions 2.937E-8 6.064E-7 3.905E-6 1.031E-5 3 11
18 int:GTF2E1 GTF2E1 interactions 2.391E-7 4.662E-6 3.002E-5 8.391E-5 4 94
19 int:GTF2E2 GTF2E2 interactions 8.536E-7 1.577E-5 1.015E-4 2.996E-4 4 129
20 int:ERCC6 ERCC6 interactions 3.879E-6 6.808E-5 4.384E-4 1.362E-3 3 52
21 int:FGL1 FGL1 interactions 9.968E-6 1.666E-4 1.073E-3 3.499E-3 3 71
22 int:XPC XPC interactions 1.129E-5 1.802E-4 1.160E-3 3.964E-3 3 74
23 int:NFE2 NFE2 interactions 1.714E-5 2.616E-4 1.685E-3 6.017E-3 3 85
24 int:GTF2F1 GTF2F1 interactions 2.963E-5 4.334E-4 2.791E-3 1.040E-2 3 102
25 int:COPS2 COPS2 interactions 6.116E-5 8.586E-4 5.529E-3 2.147E-2 3 130
26 int:MPLKIP MPLKIP interactions 7.324E-5 9.887E-4 6.367E-3 2.571E-2 2 21
27 int:E2F1 E2F1 interactions 1.134E-4 1.474E-3 9.489E-3 3.979E-2 3 160
28 int:RPA2 RPA2 interactions 1.396E-4 1.749E-3 1.127E-2 4.899E-2 4 470
29 int:XPA XPA interactions 1.723E-4 2.025E-3 1.304E-2
6.049E-2
 2 32
30 int:RPA1 RPA1 interactions 1.731E-4 2.025E-3 1.304E-2
6.076E-2
 4 497
31 int:SMAD1 SMAD1 interactions 1.914E-4 2.167E-3 1.395E-2
6.718E-2
 3 191
32 int:MMS19 MMS19 interactions 2.192E-4 2.405E-3 1.548E-2
7.695E-2
 3 200
33 int:RARB RARB interactions 2.982E-4 3.171E-3 2.042E-2
1.047E-1
 2 42
34 int:RAD52 RAD52 interactions 3.425E-4 3.536E-3 2.277E-2
1.202E-1
 2 45
35 int:CDK20 CDK20 interactions 3.898E-4 3.909E-3 2.517E-2
1.368E-1
 2 48
36 int:ZSCAN1 ZSCAN1 interactions 4.231E-4 4.013E-3 2.584E-2
1.485E-1
 2 50
37 int:TAF7 TAF7 interactions 4.231E-4 4.013E-3 2.584E-2
1.485E-1
 2 50
38 int:ERCC8 ERCC8 interactions 5.308E-4 4.902E-3 3.157E-2
1.863E-1
 2 56
39 int:SPTA1 SPTA1 interactions 6.504E-4 5.854E-3 3.769E-2
2.283E-1
 2 62
40 int:CCNC CCNC interactions 9.252E-4 8.119E-3
5.228E-2
3.248E-1
 2 74
41 int:TCEA1 TCEA1 interactions 1.027E-3 8.795E-3
5.663E-2
3.606E-1
 2 78
42 int:DDB2 DDB2 interactions 1.425E-3 1.189E-2
7.653E-2
5.002E-1
 2 92
43 int:KPNA3 KPNA3 interactions 1.456E-3 1.189E-2
7.653E-2
5.111E-1
 2 93
44 int:UBC UBC interactions 2.044E-3 1.619E-2
1.043E-1
7.175E-1
 3 431
45 int:CDK8 CDK8 interactions 2.102E-3 1.619E-2
1.043E-1
7.378E-1
 2 112
46 int:POLR2C POLR2C interactions 2.139E-3 1.619E-2
1.043E-1
7.509E-1
 2 113
47 int:GEMIN4 GEMIN4 interactions 2.214E-3 1.619E-2
1.043E-1
7.773E-1
 2 115
48 int:FUBP1 FUBP1 interactions 2.214E-3 1.619E-2
1.043E-1
7.773E-1
 2 115
49 int:UBXN7 UBXN7 interactions 2.291E-3 1.635E-2
1.053E-1
8.041E-1
 2 117
50 int:RNF11 RNF11 interactions 2.330E-3 1.635E-2
1.053E-1
8.177E-1
 2 118
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q12.1 5q12.1 2.736E-5 2.736E-4 8.014E-4 2.736E-4 2 25
2 5q13.3-q14 5q13.3-q14 6.346E-4 3.173E-3 9.293E-3 6.346E-3 1 2
3 11p15.1-p14 11p15.1-p14 9.518E-4 3.173E-3 9.293E-3 9.518E-3 1 3
4 2q21 2q21 5.067E-3 1.077E-2 3.153E-2
5.067E-2
 1 16
5 3p25 3p25 5.383E-3 1.077E-2 3.153E-2
5.383E-2
 1 17
6 7p14.1 7p14.1 8.537E-3 1.423E-2 4.167E-2
8.537E-2
 1 27
7 6q25.3 6q25.3 1.105E-2 1.579E-2 4.625E-2
1.105E-1
 1 35
8 5q13.2 5q13.2 1.763E-2 2.204E-2
6.455E-2
1.763E-1
 1 56
9 19q13.3 19q13.3 2.634E-2 2.927E-2
8.573E-2
2.634E-1
 1 84
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 19 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 565 Lysine acetyltransferases|General transcription factors genenames.org 7.362E-16 5.890E-15 1.601E-14 5.890E-15 6 25
2 1269 Nucleotide excision repair genenames.org 1.403E-10 5.611E-10 1.525E-9 1.122E-9 4 18
3 1268 General transcription factors|Xeroderma pigmentosum complementation groups|DNA helicases|ERCC excision repair associated genenames.org 4.180E-9 1.115E-8 3.030E-8 3.344E-8 3 7
4 1125 Xeroderma pigmentosum complementation groups genenames.org 6.686E-9 1.337E-8 3.634E-8 5.349E-8 3 8
5 1167 INO80 complex |DNA helicases genenames.org 3.682E-5 5.891E-5 1.601E-4 2.945E-4 2 17
6 496 Cyclin dependent kinases genenames.org 1.420E-2 1.809E-2 4.917E-2
1.136E-1
 1 26
7 473 Cyclins genenames.org 1.583E-2 1.809E-2 4.917E-2
1.266E-1
 1 29
Show 2 more annotations

13: Coexpression [Display Chart] 11 input genes in category / 806 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.443E-20 6.805E-17 4.947E-16 6.805E-17 10 230
2 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 3.020E-11 1.217E-8 8.849E-8 2.434E-8 6 150
3 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.158E-8 3.110E-6 2.261E-5 9.331E-6 4 58
4 M15123 Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.267E-8 1.867E-5 1.358E-4 7.469E-5 5 271
5 M5590 Genes down-regulated in comparison of central memory CD4 [GeneID=920] T cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.705E-6 2.749E-4 1.998E-3 1.374E-3 4 200
6 19749795-Table2 Human Leukemia Ueno09 26genes GeneSigDB 3.131E-5 4.206E-3 3.058E-2 2.524E-2 2 18
7 M3299 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 21 days after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 9.683E-5 1.115E-2
8.105E-2
7.804E-2
 3 198
8 15705876-TableS4 Human Leukemia Passioura05 43genes GeneSigDB 1.836E-4 1.850E-2
1.345E-1
1.480E-1
 2 43
9 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.703E-4 3.299E-2
2.398E-1
2.985E-1
 2 61
10 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.093E-4 3.299E-2
2.398E-1
3.299E-1
 3 323
11 M2510 Genes down-regulated in HL-60 cells (promyeloid leukemia) by cantharidin [PubChem=6708701]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.738E-4 3.472E-2
2.524E-1
3.819E-1
 2 69
12 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 5.802E-4 3.897E-2
2.833E-1
4.676E-1
 3 364
13 M4151 Genes up-regulated in primary fibroblast cells by expression of p50 (NFKB1) and p65 (RELA) [GeneID=4790;5970] components of NFKB. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.013E-4 4.348E-2
3.161E-1
5.652E-1
 2 84
14 M11951 Genes up-regulated in primary keratinocytes by expression of p50 (NFKB1) and p65 (RELA) [GeneID=4790;5970] components of NFKB. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.223E-4 4.655E-2
3.384E-1
6.628E-1
 2 91
15 M17860 Genes down-regulated in primary tissue culture of epidermal kerationcytes after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.527E-4 4.655E-2
3.384E-1
7.679E-1
 2 98
16 15705876-TableS6 Human Leukemia Passioura05 105genes GeneSigDB 9.527E-4 4.655E-2
3.384E-1
7.679E-1
 2 98
17 M5949 Genes encoding components of peroxisome. MSigDB H: Hallmark Gene Sets (v6.0) 1.072E-3 4.655E-2
3.384E-1
8.639E-1
 2 104
18 M2544 Genes up-regulated in liver samples containing tumor thrombi in the major branches of the portal vein at surgery (PT) compared to those from metastasis-free HCC patients (PN) at the time of surgery and at follow-up. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.113E-3 4.655E-2
3.384E-1
8.972E-1
 2 106
19 M459 Cluster 0: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.134E-3 4.655E-2
3.384E-1
9.140E-1
 2 107
20 M7160 Genes up-regulated in PANC-1-puro cells (pancreatic cancer) stimulated by TGF1B [GeneID=7040] for 2 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.155E-3 4.655E-2
3.384E-1
9.310E-1
 2 108
21 M12313 Genes up-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.353E-3 4.970E-2
3.613E-1
1.000E0
 2 117
22 14562049-Table2 Human StemCell Young03 142genes GeneSigDB 1.567E-3 4.970E-2
3.613E-1
1.000E0
 2 126
23 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.617E-3 4.970E-2
3.613E-1
1.000E0
 2 128
24 16434974-Table1 Human StemCell Enk06 139genes GeneSigDB 1.667E-3 4.970E-2
3.613E-1
1.000E0
 2 130
25 M17742 Genes consistently up-regulated in HMEC cells (primary mammary epithelium) upon expression of TERT [GeneID=7015] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.067E-3 4.970E-2
3.613E-1
1.000E0
 2 145
26 M19152 Genes down-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.067E-3 4.970E-2
3.613E-1
1.000E0
 2 145
27 M6760 Genes up-regulated in cells from Flt3L Melanom injected mice: splenic DEC205+ dendritic cells versus B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.124E-3 4.970E-2
3.613E-1
1.000E0
 2 147
28 M2990 Genes down-regulated in B lymphocytes with ZFX [GeneID=7543] knockout: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.761E-3 4.970E-2
3.613E-1
1.000E0
 2 168
29 19373655-Table3 Mouse Lymphoma Saez09 16genes GeneSigDB 3.324E-3 4.970E-2
3.613E-1
1.000E0
 1 7
30 18661203-Table3 Mouse Uterine Kashiwazaki08 9genes GeneSigDB 3.324E-3 4.970E-2
3.613E-1
1.000E0
 1 7
31 M2812 Genes down-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 3.406E-3 4.970E-2
3.613E-1
1.000E0
 2 187
32 M5960 Genes up-regulated in livers: SOCS3 [GeneID=9021] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
33 M3028 Genes down-regulated in comparison of naive versus memory CD8 T cells (day 40+ following LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
34 M4176 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
35 M8404 Genes up-regulated in spleen CD8- dendritic cells versus bone marrow monocytes. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
36 M6098 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus IL-12 (6h). MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
37 M3401 Genes down-regulated in comparison of control microglia cells versus those 1 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
38 M5511 Genes down-regulated in comparison of macrophages versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 3.847E-3 4.970E-2
3.613E-1
1.000E0
 2 199
39 M6832 Genes up-regulated in response to anti-FcgRIIB: dendritic cells versus monocytes. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
40 M4307 Genes down-regulated in comparison of naive vs effector CD8 T cells (3.5 days postinfection). MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
41 M7436 Genes down-regulated in CD4 [GeneID=920] T cells: TGF beta versus TGF beta and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
42 M4159 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
43 M4564 Genes down-regulated in comparison of adult thymic progenitors versus adult DN3 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
44 M5296 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
45 M5595 Genes down-regulated in comparison of NK cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
46 M6991 Genes down-regulated in allogeneic T cells after stimulation with dendritic cells from: liver versus mesenteric lymph nodes (mLN). MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
47 M4004 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
48 M8391 Genes down-regulated in spleen dendritic cells: CD8- versus CD8+. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
49 M6192 Genes up-regulated in polymorphonuclear leukocytes (9h): S. aureus infection versus control. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
50 M3025 Genes down-regulated in comparison of effector CD8 T cells at the peak expansion phase (day8) versus those at contraction (day 15) after LCMV-Armstrong infection. MSigDB C7: Immunologic Signatures (v6.0) 3.885E-3 4.970E-2
3.613E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 11 input genes in category / 212 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 8 input genes in category / 51 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.430E-4 7.291E-3 3.295E-2 7.291E-3 4 393
2 M8951 MORF RAB11A Neighborhood of RAB11A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.298E-4 2.371E-2
1.071E-1
 4.742E-2 2 59

16: MicroRNA [Display Chart] 11 input genes in category / 340 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.154E-5 7.153E-3 4.583E-2 1.412E-2 3 463
2 hsa-miR-6727-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.207E-5 7.153E-3 4.583E-2 1.431E-2 3 465
3 hsa-miR-562:Functional MTI Functional MTI miRTarbase 1.643E-4 1.862E-2
1.193E-1
5.586E-2
 2 126
4 hsa-miR-6514-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.205E-4 1.874E-2
1.201E-1
7.496E-2
 2 146
5 hsa-miR-107:Functional MTI Functional MTI miRTarbase 9.222E-4 4.383E-2
2.808E-1
3.136E-1
 2 300
6 hsa-miR-8055:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.035E-3 4.383E-2
2.808E-1
3.519E-1
 2 318
7 hsa-miR-340*:mirSVR highEffct hsa-miR-340*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.456E-3 4.383E-2
2.808E-1
4.949E-1
 2 378
8 hsa-miR-3135b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.580E-3 4.383E-2
2.808E-1
5.371E-1
 2 394
9 hsa-miR-4430:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.603E-3 4.383E-2
2.808E-1
5.452E-1
 2 397
10 hsa-miR-3652:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.603E-3 4.383E-2
2.808E-1
5.452E-1
 2 397
11 hsa-miR-553:mirSVR highEffct hsa-miR-553:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.635E-3 4.383E-2
2.808E-1
5.560E-1
 2 401
12 hsa-miR-5095:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.643E-3 4.383E-2
2.808E-1
5.588E-1
 2 402
13 hsa-miR-331-3p:Functional MTI Functional MTI miRTarbase 1.676E-3 4.383E-2
2.808E-1
5.698E-1
 2 406
Show 8 more annotations

17: Drug [Display Chart] 11 input genes in category / 1628 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000000193 S-adenosyl-D-homocysteine Stitch 2.380E-12 1.376E-9 1.097E-8 3.874E-9 7 222
2 CID006852127 Asn-SA Stitch 2.467E-12 1.376E-9 1.097E-8 4.016E-9 5 34
3 CID000000593 NSC20261 Stitch 2.535E-12 1.376E-9 1.097E-8 4.127E-9 7 224
4 CID000000761 5'-GMP Na2 Stitch 4.304E-11 1.752E-8 1.397E-7 7.007E-8 7 335
5 CID000001079 S-adenosylmethionine Stitch 6.462E-11 2.104E-8 1.677E-7 1.052E-7 7 355
6 ctd:C408982 CPG-oligonucleotide CTD 1.125E-10 2.700E-8 2.153E-7 1.832E-7 6 184
7 CID000000181 AC1Q68Z5 Stitch 1.161E-10 2.700E-8 2.153E-7 1.890E-7 7 386
8 CID000001181 UTP-NA Stitch 2.095E-10 4.027E-8 3.211E-7 3.410E-7 7 420
9 CID000001652 3-deazacytidine Stitch 2.226E-10 4.027E-8 3.211E-7 3.624E-7 6 206
10 CID000022469 N-acetoxy-2-acetylaminofluorene Stitch 1.907E-9 3.104E-7 2.475E-6 3.104E-6 4 37
11 CID000327967 AC1L71LQ Stitch 3.483E-9 5.155E-7 4.110E-6 5.671E-6 5 139
12 CID006444056 BIDS Stitch 3.016E-8 4.091E-6 3.262E-5 4.910E-5 3 14
13 ctd:C547185 riccardin D CTD 3.669E-8 4.594E-6 3.663E-5 5.973E-5 4 76
14 ctd:D001115 Arecoline CTD 6.058E-8 7.044E-6 5.616E-5 9.862E-5 4 86
15 CID000085645 iodine heptafluoride Stitch 1.100E-7 1.194E-5 9.517E-5 1.791E-4 3 21
16 CID000101109 illudin S Stitch 2.704E-7 2.752E-5 2.194E-4 4.402E-4 3 28
17 CID005289542 UV-C Stitch 7.933E-7 7.597E-5 6.057E-4 1.292E-3 4 163
18 ctd:C005246 myristicin CTD 1.166E-6 1.055E-4 8.408E-4 1.898E-3 3 45
19 CID000023939 platinum Stitch 1.259E-6 1.079E-4 8.603E-4 2.050E-3 4 183
20 CID000016054 5-hydroxyindole Stitch 1.609E-6 1.309E-4 1.044E-3 2.619E-3 3 50
21 CID000148189 irofulven Stitch 1.709E-6 1.325E-4 1.056E-3 2.782E-3 3 51
22 CID000065361 polyAT Stitch 2.107E-6 1.559E-4 1.243E-3 3.430E-3 2 5
23 ctd:C056493 imiquimod CTD 3.914E-6 2.770E-4 2.209E-3 6.372E-3 3 67
24 CID000003082 dimethoate Stitch 4.665E-6 3.164E-4 2.523E-3 7.594E-3 3 71
25 CID005469591 NSC-690579 Stitch 5.961E-6 3.882E-4 3.095E-3 9.704E-3 3 77
26 CID000002353 berberine Stitch 6.816E-6 4.268E-4 3.403E-3 1.110E-2 4 280
27 CID000043188 IF-7 Stitch 9.468E-6 5.709E-4 4.552E-3 1.541E-2 2 10
28 CID000003199 NSC648766 Stitch 1.053E-5 6.091E-4 4.856E-3 1.714E-2 3 93
29 CID000001135 thymine Stitch 1.085E-5 6.091E-4 4.856E-3 1.766E-2 4 315
30 ctd:C000589248 LL-202 CTD 1.157E-5 6.278E-4 5.006E-3 1.884E-2 2 11
31 CID000064548 AC1L21FQ Stitch 1.640E-5 8.612E-4 6.866E-3 2.670E-2 2 13
32 CID000119315 8-oxyguanine Stitch 2.875E-5 1.463E-3 1.166E-2 4.680E-2 3 130
33 CID000024472 chloroethylene oxide Stitch 3.213E-5 1.585E-3 1.264E-2
5.230E-2
 2 18
34 CID000119184 CNDAC Stitch 3.987E-5 1.909E-3 1.522E-2
6.491E-2
 2 20
35 CID000008761 bicine Stitch 4.406E-5 2.049E-3 1.634E-2
7.173E-2
 2 21
36 CID000072271 UCN-01 Stitch 4.766E-5 2.156E-3 1.719E-2
7.760E-2
 3 154
37 CID000013764 AC1L22FD Stitch 6.810E-5 2.996E-3 2.389E-2
1.109E-1
 2 26
38 CID006450878 Etiocobalamin Stitch 7.212E-5 3.090E-3 2.463E-2
1.174E-1
 3 177
39 CID000150345 AC1L445C Stitch 8.500E-5 3.548E-3 2.829E-2
1.384E-1
 2 29
40 1947 UP Hesperetin [520-33-2]; Up 200; 13.2uM; PC3; HG-U133A Broad Institute CMAP Up 9.908E-5 3.934E-3 3.137E-2
1.613E-1
 3 197
41 624 UP DAPH; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Up 9.908E-5 3.934E-3 3.137E-2
1.613E-1
 3 197
42 CID006331933 AC1O3LYN Stitch 1.038E-4 4.022E-3 3.207E-2
1.689E-1
 2 32
43 CID009547890 N6-9 Stitch 1.173E-4 4.441E-3 3.541E-2
1.910E-1
 2 34
44 CID000126592 NSC668281 Stitch 1.317E-4 4.871E-3 3.884E-2
2.143E-1
 2 36
45 CID000075394 1-(2-chloroethyl)-1-nitrosourea Stitch 1.796E-4 6.499E-3
5.182E-2
2.925E-1
 2 42
46 CID000002210 NSC351140 Stitch 2.198E-4 7.779E-3
6.202E-2
3.578E-1
 3 258
47 CID000001134 deoxythymidin Stitch 2.680E-4 9.284E-3
7.402E-2
4.363E-1
 3 276
48 ctd:C017160 cypermethrin CTD 3.006E-4 1.020E-2
8.129E-2
4.894E-1
 3 287
49 CID000000665 AC1Q6S3P Stitch 4.053E-4 1.346E-2
1.073E-1
6.597E-1
 2 63
50 CID000469074 adenosine analog Stitch 4.182E-4 1.362E-2
1.086E-1
6.809E-1
 2 64
Show 45 more annotations

18: Disease [Display Chart] 11 input genes in category / 435 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1955934 Trichothiodystrophy Syndromes DisGeNET Curated 2.183E-21 9.496E-19 6.318E-18 9.496E-19 8 26
2 C0009207 Cockayne Syndrome DisGeNET Curated 1.476E-17 3.209E-15 2.135E-14 6.419E-15 8 71
3 C0268136 Xeroderma pigmentosum, group B DisGeNET Curated 3.149E-17 4.566E-15 3.038E-14 1.370E-14 6 13
4 C0268135 Xeroderma pigmentosum, group A DisGeNET Curated 1.050E-16 1.142E-14 7.601E-14 4.570E-14 7 40
5 C0035613 Rift Valley Fever DisGeNET BeFree 7.100E-16 6.177E-14 4.110E-13 3.088E-13 6 20
6 C0043116 HMN (Hereditary Motor Neuropathy) Proximal Type I DisGeNET Curated 5.412E-15 3.586E-13 2.386E-12 2.354E-12 6 27
7 C0018553 Hamartoma Syndrome, Multiple DisGeNET Curated 5.770E-15 3.586E-13 2.386E-12 2.510E-12 8 146
8 C0231341 Premature aging syndrome DisGeNET Curated 3.841E-14 2.089E-12 1.390E-11 1.671E-11 7 89
9 C0043346 Xeroderma Pigmentosum DisGeNET Curated 1.354E-13 6.543E-12 4.353E-11 5.888E-11 7 106
10 C0268138 Xeroderma Pigmentosum, Complementation Group D DisGeNET Curated 4.689E-13 2.040E-11 1.357E-10 2.040E-10 6 54
11 C0007682 CNS disorder DisGeNET Curated 6.854E-11 2.710E-9 1.803E-8 2.981E-8 6 121
12 C0007114 Malignant neoplasm of skin DisGeNET Curated 9.761E-11 3.538E-9 2.354E-8 4.246E-8 7 268
13 C1866504 Photosensitive Trichothiodystrophy DisGeNET Curated 2.327E-10 6.748E-9 4.490E-8 1.012E-7 3 3
14 cv:C1866504 Photosensitive trichothiodystrophy Clinical Variations 2.327E-10 6.748E-9 4.490E-8 1.012E-7 3 3
15 OMIN:601675 TRICHOTHIODYSTROPHY, PHOTOSENSITIVE; TTDP OMIM 2.327E-10 6.748E-9 4.490E-8 1.012E-7 3 3
16 C0026847 Spinal Muscular Atrophy DisGeNET Curated 1.056E-9 2.872E-8 1.911E-7 4.595E-7 6 190
17 C0016689 Freckles DisGeNET Curated 4.654E-9 1.191E-7 7.925E-7 2.025E-6 4 33
18 C0349506 Photosensitivity of skin DisGeNET Curated 3.850E-8 9.304E-7 6.191E-6 1.675E-5 4 55
19 C0037274 Dermatologic disorders DisGeNET Curated 8.165E-8 1.835E-6 1.221E-5 3.552E-5 6 393
20 C0239105 Conjunctival telangiectasis DisGeNET Curated 8.435E-8 1.835E-6 1.221E-5 3.669E-5 3 14
21 C1833561 UV-Sensitive Syndrome DisGeNET BeFree 1.297E-7 2.686E-6 1.787E-5 5.641E-5 3 16
22 C0259817 Xerosis DisGeNET Curated 1.682E-7 3.326E-6 2.213E-5 7.317E-5 4 79
23 C0392777 Poikiloderma DisGeNET Curated 2.241E-7 4.239E-6 2.821E-5 9.750E-5 3 19
24 C0151908 Dry skin DisGeNET Curated 2.485E-7 4.504E-6 2.997E-5 1.081E-4 4 87
25 C1862314 Basal cell nevi DisGeNET Curated 4.090E-7 6.844E-6 4.554E-5 1.779E-4 3 23
26 C0751038 Cockayne Syndrome, Type II DisGeNET Curated 4.090E-7 6.844E-6 4.554E-5 1.779E-4 3 23
27 C0263490 Brittle hair DisGeNET Curated 6.746E-7 1.087E-5 7.231E-5 2.934E-4 3 27
28 C1857707 Increased cellular sensitivity to UV light DisGeNET Curated 1.256E-6 1.952E-5 1.299E-4 5.465E-4 2 3
29 C0020619 Hypogonadism DisGeNET Curated 1.680E-6 2.520E-5 1.677E-4 7.309E-4 4 140
30 C1846149 Progressive mental retardation DisGeNET Curated 1.785E-6 2.589E-5 1.722E-4 7.766E-4 3 37
31 C4022018 Telangiectasia of the skin DisGeNET Curated 2.268E-6 3.182E-5 2.117E-4 9.864E-4 3 40
32 C1968565 Numerous pigmented freckles DisGeNET Curated 2.512E-6 3.414E-5 2.272E-4 1.093E-3 2 4
33 C1842774 Hyperpigmented macules DisGeNET Curated 2.829E-6 3.730E-5 2.482E-4 1.231E-3 3 43
34 C0151514 Atrophic condition of skin DisGeNET Curated 3.314E-6 4.240E-5 2.821E-4 1.441E-3 4 166
35 C0423757 Thin skin DisGeNET Curated 3.712E-6 4.613E-5 3.070E-4 1.615E-3 3 47
36 C0751039 Cockayne Syndrome, Type I DisGeNET Curated 4.482E-6 5.416E-5 3.603E-4 1.950E-3 3 50
37 C0007117 Basal cell carcinoma DisGeNET Curated 5.050E-6 5.937E-5 3.950E-4 2.197E-3 3 52
38 C4280568 Hardened artery wall DisGeNET Curated 6.274E-6 7.182E-5 4.779E-4 2.729E-3 2 6
39 C1836735 hypopigmented skin patch DisGeNET Curated 7.796E-6 8.696E-5 5.786E-4 3.391E-3 3 60
40 C0262444 Dental abnormalities DisGeNET Curated 8.196E-6 8.913E-5 5.931E-4 3.565E-3 3 61
41 C1968564 Defective DNA repair after ultraviolet radiation damage DisGeNET Curated 8.781E-6 9.316E-5 6.199E-4 3.820E-3 2 7
42 C0022568 Keratitis DisGeNET Curated 9.478E-6 9.816E-5 6.532E-4 4.123E-3 3 64
43 C0220722 Cerebrooculofacioskeletal Syndrome 1 DisGeNET Curated 1.170E-5 1.157E-4 7.699E-4 5.091E-3 2 8
44 C0014390 Entropion DisGeNET Curated 1.170E-5 1.157E-4 7.699E-4 5.091E-3 2 8
45 C1510497 Lens Opacities DisGeNET Curated 1.248E-5 1.207E-4 8.030E-4 5.431E-3 4 232
46 C0040427 Tooth Abnormalities DisGeNET Curated 1.410E-5 1.333E-4 8.873E-4 6.134E-3 3 73
47 C1857710 Wizened face DisGeNET Curated 1.504E-5 1.392E-4 9.263E-4 6.543E-3 2 9
48 C0029124 Optic Atrophy DisGeNET Curated 1.676E-5 1.519E-4 1.011E-3 7.290E-3 4 250
49 C1858160 CRANIOSYNOSTOSIS, TYPE 2 DisGeNET Curated 2.296E-5 2.009E-4 1.337E-3 9.989E-3 2 11
50 C0016382 Flushing DisGeNET Curated 2.309E-5 2.009E-4 1.337E-3 1.004E-2 3 86
Show 45 more annotations