Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc254_11, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 10 input genes in category / 61 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051082 unfolded protein binding 5.033E-12 3.070E-10 1.442E-9 3.070E-10 6 103
2 GO:0051087 chaperone binding 7.127E-8 2.174E-6 1.021E-5 4.347E-6 4 82
3 GO:0031072 heat shock protein binding 2.077E-5 4.223E-4 1.983E-3 1.267E-3 3 106
4 GO:0030544 Hsp70 protein binding 1.437E-4 1.967E-3 9.239E-3 8.764E-3 2 34
5 GO:0051879 Hsp90 protein binding 1.613E-4 1.967E-3 9.239E-3 9.837E-3 2 36
6 GO:0016860 intramolecular oxidoreductase activity 3.780E-4 3.843E-3 1.805E-2 2.306E-2 2 55
7 GO:0050220 prostaglandin-E synthase activity 1.607E-3 1.400E-2
6.576E-2
9.802E-2
 1 3
8 GO:0030911 TPR domain binding 2.677E-3 2.041E-2
9.585E-2
1.633E-1
 1 5
9 GO:0016853 isomerase activity 3.539E-3 2.398E-2
1.126E-1
2.159E-1
 2 170
10 GO:0046790 virion binding 5.880E-3 3.255E-2
1.529E-1
3.587E-1
 1 11
11 GO:0034450 ubiquitin-ubiquitin ligase activity 6.946E-3 3.255E-2
1.529E-1
4.237E-1
 1 13
12 GO:0051787 misfolded protein binding 6.946E-3 3.255E-2
1.529E-1
4.237E-1
 1 13
13 GO:0003720 telomerase activity 7.479E-3 3.255E-2
1.529E-1
4.562E-1
 1 14
14 GO:0044183 protein binding involved in protein folding 8.011E-3 3.255E-2
1.529E-1
4.887E-1
 1 15
15 GO:0031625 ubiquitin protein ligase binding 8.880E-3 3.255E-2
1.529E-1
5.417E-1
 2 273
16 GO:0044389 ubiquitin-like protein ligase binding 9.133E-3 3.255E-2
1.529E-1
5.571E-1
 2 277
17 GO:0050750 low-density lipoprotein particle receptor binding 9.606E-3 3.255E-2
1.529E-1
5.860E-1
 1 18
18 GO:0001671 ATPase activator activity 9.606E-3 3.255E-2
1.529E-1
5.860E-1
 1 18
19 GO:0003964 RNA-directed DNA polymerase activity 1.120E-2 3.399E-2
1.596E-1
6.832E-1
 1 21
20 GO:0070325 lipoprotein particle receptor binding 1.226E-2 3.399E-2
1.596E-1
7.479E-1
 1 23
21 GO:0003756 protein disulfide isomerase activity 1.226E-2 3.399E-2
1.596E-1
7.479E-1
 1 23
22 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1.226E-2 3.399E-2
1.596E-1
7.479E-1
 1 23
23 GO:0060590 ATPase regulator activity 1.702E-2 4.514E-2
2.120E-1
1.000E0
 1 32
24 GO:0004857 enzyme inhibitor activity 1.780E-2 4.525E-2
2.125E-1
1.000E0
 2 393
Show 19 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 287 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006457 protein folding 7.824E-10 2.246E-7 1.401E-6 2.246E-7 6 236
2 GO:0006986 response to unfolded protein 1.480E-6 1.744E-4 1.088E-3 4.247E-4 4 174
3 GO:0035966 response to topologically incorrect protein 1.849E-6 1.744E-4 1.088E-3 5.307E-4 4 184
4 GO:0061077 chaperone-mediated protein folding 2.430E-6 1.744E-4 1.088E-3 6.975E-4 3 52
5 GO:0051131 chaperone-mediated protein complex assembly 2.715E-5 1.342E-3 8.375E-3 7.791E-3 2 15
6 GO:0051604 protein maturation 2.806E-5 1.342E-3 8.375E-3 8.055E-3 4 366
7 GO:0051084 'de novo' posttranslational protein folding 3.952E-5 1.621E-3 1.011E-2 1.134E-2 2 18
8 GO:0006458 'de novo' protein folding 5.961E-5 2.138E-3 1.334E-2 1.711E-2 2 22
9 GO:0034976 response to endoplasmic reticulum stress 3.175E-4 1.012E-2
6.316E-2
9.112E-2
 3 265
10 GO:0006278 RNA-dependent DNA biosynthetic process 5.301E-4 1.401E-2
8.740E-2
1.522E-1
 2 65
11 GO:0051086 chaperone mediated protein folding independent of cofactor 5.370E-4 1.401E-2
8.740E-2
1.541E-1
 1 1
12 GO:0036503 ERAD pathway 9.260E-4 1.926E-2
1.201E-1
2.658E-1
 2 86
13 GO:0043335 protein unfolding 1.074E-3 1.926E-2
1.201E-1
3.081E-1
 1 2
14 GO:0090035 positive regulation of chaperone-mediated protein complex assembly 1.074E-3 1.926E-2
1.201E-1
3.081E-1
 1 2
15 GO:0031247 actin rod assembly 1.074E-3 1.926E-2
1.201E-1
3.081E-1
 1 2
16 GO:0090034 regulation of chaperone-mediated protein complex assembly 1.074E-3 1.926E-2
1.201E-1
3.081E-1
 1 2
17 GO:0030968 endoplasmic reticulum unfolded protein response 2.098E-3 3.314E-2
2.068E-1
6.020E-1
 2 130
18 GO:0090666 scaRNA localization to Cajal body 2.146E-3 3.314E-2
2.068E-1
6.160E-1
 1 4
19 GO:0034620 cellular response to unfolded protein 2.194E-3 3.314E-2
2.068E-1
6.297E-1
 2 133
20 GO:0000723 telomere maintenance 2.427E-3 3.364E-2
2.099E-1
6.966E-1
 2 140
21 GO:0035967 cellular response to topologically incorrect protein 2.461E-3 3.364E-2
2.099E-1
7.064E-1
 2 141
22 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis 2.682E-3 3.499E-2
2.183E-1
7.698E-1
 1 5
23 GO:0032200 telomere organization 2.890E-3 3.606E-2
2.250E-1
8.294E-1
 2 153
24 GO:0030579 ubiquitin-dependent SMAD protein catabolic process 3.218E-3 3.848E-2
2.401E-1
9.235E-1
 1 6
25 GO:1904869 regulation of protein localization to Cajal body 4.289E-3 4.192E-2
2.615E-1
1.000E0
 1 8
26 GO:1904871 positive regulation of protein localization to Cajal body 4.289E-3 4.192E-2
2.615E-1
1.000E0
 1 8
27 GO:1904851 positive regulation of establishment of protein localization to telomere 4.823E-3 4.192E-2
2.615E-1
1.000E0
 1 9
28 GO:1990173 protein localization to nucleoplasm 4.823E-3 4.192E-2
2.615E-1
1.000E0
 1 9
29 GO:1904867 protein localization to Cajal body 4.823E-3 4.192E-2
2.615E-1
1.000E0
 1 9
30 GO:0031943 regulation of glucocorticoid metabolic process 4.823E-3 4.192E-2
2.615E-1
1.000E0
 1 9
31 GO:1903405 protein localization to nuclear body 4.823E-3 4.192E-2
2.615E-1
1.000E0
 1 9
32 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis 4.823E-3 4.192E-2
2.615E-1
1.000E0
 1 9
33 GO:0042445 hormone metabolic process 5.267E-3 4.192E-2
2.615E-1
1.000E0
 2 208
34 GO:0036500 ATF6-mediated unfolded protein response 5.358E-3 4.192E-2
2.615E-1
1.000E0
 1 10
35 GO:0070203 regulation of establishment of protein localization to telomere 5.358E-3 4.192E-2
2.615E-1
1.000E0
 1 10
36 GO:0071897 DNA biosynthetic process 5.415E-3 4.192E-2
2.615E-1
1.000E0
 2 211
37 GO:0019371 cyclooxygenase pathway 5.892E-3 4.192E-2
2.615E-1
1.000E0
 1 11
38 GO:0060430 lung saccule development 5.892E-3 4.192E-2
2.615E-1
1.000E0
 1 11
39 GO:0070202 regulation of establishment of protein localization to chromosome 5.892E-3 4.192E-2
2.615E-1
1.000E0
 1 11
40 GO:0034975 protein folding in endoplasmic reticulum 5.892E-3 4.192E-2
2.615E-1
1.000E0
 1 11
41 GO:0071218 cellular response to misfolded protein 6.427E-3 4.192E-2
2.615E-1
1.000E0
 1 12
42 GO:0071318 cellular response to ATP 6.427E-3 4.192E-2
2.615E-1
1.000E0
 1 12
43 GO:1904816 positive regulation of protein localization to chromosome, telomeric region 6.427E-3 4.192E-2
2.615E-1
1.000E0
 1 12
44 GO:0051085 chaperone cofactor-dependent protein refolding 6.427E-3 4.192E-2
2.615E-1
1.000E0
 1 12
45 GO:0031647 regulation of protein stability 6.785E-3 4.327E-2
2.700E-1
1.000E0
 2 237
46 GO:1904814 regulation of protein localization to chromosome, telomeric region 7.494E-3 4.608E-2
2.874E-1
1.000E0
 1 14
47 GO:1904872 regulation of telomerase RNA localization to Cajal body 8.027E-3 4.608E-2
2.874E-1
1.000E0
 1 15
48 GO:0070200 establishment of protein localization to telomere 8.027E-3 4.608E-2
2.874E-1
1.000E0
 1 15
49 GO:0051788 response to misfolded protein 8.027E-3 4.608E-2
2.874E-1
1.000E0
 1 15
50 GO:1904874 positive regulation of telomerase RNA localization to Cajal body 8.027E-3 4.608E-2
2.874E-1
1.000E0
 1 15
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 10 input genes in category / 42 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005788 endoplasmic reticulum lumen 1.432E-4 3.815E-3 1.651E-2 6.014E-3 3 207
2 GO:0005790 smooth endoplasmic reticulum 1.817E-4 3.815E-3 1.651E-2 7.630E-3 2 39
3 GO:0042470 melanosome 1.314E-3 1.380E-2
5.970E-2
5.519E-2
 2 105
4 GO:0048770 pigment granule 1.314E-3 1.380E-2
5.970E-2
5.519E-2
 2 105
5 GO:0005832 chaperonin-containing T-complex 4.713E-3 2.637E-2
1.141E-1
1.979E-1
 1 9
6 GO:0031371 ubiquitin conjugating enzyme complex 4.713E-3 2.637E-2
1.141E-1
1.979E-1
 1 9
7 GO:0043209 myelin sheath 4.755E-3 2.637E-2
1.141E-1
1.997E-1
 2 202
8 GO:0002199 zona pellucida receptor complex 5.757E-3 2.637E-2
1.141E-1
2.418E-1
 1 11
9 GO:0034663 endoplasmic reticulum chaperone complex 6.279E-3 2.637E-2
1.141E-1
2.637E-1
 1 12
10 GO:0042405 nuclear inclusion body 6.279E-3 2.637E-2
1.141E-1
2.637E-1
 1 12
11 GO:0071682 endocytic vesicle lumen 8.885E-3 3.392E-2
1.468E-1
3.732E-1
 1 17
12 GO:0005697 telomerase holoenzyme complex 9.926E-3 3.474E-2
1.503E-1
4.169E-1
 1 19
Show 7 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 127 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 297 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 10 input genes in category / 85 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00014 ER TARGET PROSITE 1.754E-6 1.491E-4 7.492E-4 1.491E-4 3 47
2 PS00681 CHAPERONINS CPN10 PROSITE 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
3 IPR016855 ER p29 InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
4 IPR033547 SERPINH1 InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
5 PF05281 Secretogranin V Pfam 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
6 IPR011679 ER p29 C InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
7 SM00883 Cpn10 SMART 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
8 IPR012883 ERp29 N InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
9 IPR013538 Activator of Hsp90 ATPase InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
10 IPR033830 Serpin H1 domain InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
11 2.30.33.40 - Gene3D 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
12 IPR020818 Chaperonin GroES InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
13 PF00166 Cpn10 Pfam 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
14 PF07912 ERp29 N Pfam 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
15 IPR018369 Chaprnonin Cpn10 CS InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
16 IPR012716 Chap CCT beta InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
17 IPR007945 Secretogranin V InterPro 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
18 PF07749 ERp29 Pfam 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
19 PF08327 AHSA1 Pfam 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
20 1.20.1150.12 - Gene3D 5.338E-4 2.268E-3 1.140E-2 4.537E-2 1 1
21 PF00515 TPR 1 Pfam 1.002E-3 3.629E-3 1.824E-2
8.513E-2
 2 90
22 IPR001440 TPR 1 InterPro 1.002E-3 3.629E-3 1.824E-2
8.513E-2
 2 90
23 IPR015310 AHSA1 N InterPro 1.067E-3 3.629E-3 1.824E-2
9.072E-2
 1 2
24 SM01000 Aha1 N SMART 1.067E-3 3.629E-3 1.824E-2
9.072E-2
 1 2
25 PF09229 Aha1 N Pfam 1.067E-3 3.629E-3 1.824E-2
9.072E-2
 1 2
26 IPR019805 Heat shock protein 90 CS InterPro 1.601E-3 5.232E-3 2.630E-2
1.360E-1
 1 3
27 SM00028 TPR SMART 2.042E-3 5.760E-3 2.895E-2
1.736E-1
 2 129
28 IPR020575 Hsp90 N InterPro 2.134E-3 5.760E-3 2.895E-2
1.813E-1
 1 4
29 PF00183 HSP90 Pfam 2.134E-3 5.760E-3 2.895E-2
1.813E-1
 1 4
30 PS00298 HSP90 PROSITE 2.134E-3 5.760E-3 2.895E-2
1.813E-1
 1 4
31 IPR001404 Hsp90 fam InterPro 2.134E-3 5.760E-3 2.895E-2
1.813E-1
 1 4
32 IPR019734 TPR repeat InterPro 2.168E-3 5.760E-3 2.895E-2
1.843E-1
 2 133
33 IPR013026 TPR-contain dom InterPro 2.747E-3 7.076E-3 3.556E-2
2.335E-1
 2 150
34 PS50005 TPR PROSITE 3.312E-3 8.043E-3 4.042E-2
2.815E-1
 2 165
35 PS50293 TPR REGION PROSITE 3.312E-3 8.043E-3 4.042E-2
2.815E-1
 2 165
36 PS51698 U BOX PROSITE 3.731E-3 8.571E-3 4.308E-2
3.171E-1
 1 7
37 PF13414 TPR 11 Pfam 3.731E-3 8.571E-3 4.308E-2
3.171E-1
 1 7
38 SM00504 Ubox SMART 4.263E-3 9.239E-3 4.643E-2
3.623E-1
 1 8
39 PF04564 U-box Pfam 4.263E-3 9.239E-3 4.643E-2
3.623E-1
 1 8
40 IPR001844 Chaprnin Cpn60 InterPro 4.795E-3 9.239E-3 4.643E-2
4.075E-1
 1 9
41 IPR002194 Chaperonin TCP-1 CS InterPro 4.795E-3 9.239E-3 4.643E-2
4.075E-1
 1 9
42 1.25.40.10 - Gene3D 5.206E-3 9.239E-3 4.643E-2
4.425E-1
 2 208
43 SM00727 STI1 SMART 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
44 IPR006636 STI1 HS-bd InterPro 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
45 IPR017998 Chaperone TCP-1 InterPro 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
46 PS00751 TCP1 2 PROSITE 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
47 IPR003613 Ubox domain InterPro 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
48 PS00995 TCP1 3 PROSITE 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
49 PS00750 TCP1 1 PROSITE 5.326E-3 9.239E-3 4.643E-2
4.527E-1
 1 10
50 3.30.260.10 - Gene3D 5.857E-3 9.762E-3 4.906E-2
4.979E-1
 1 11
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 58 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 7.834E-5 4.544E-3 2.111E-2 4.544E-3 3 166
2 545299 C20 prostanoid biosynthesis BioSystems: BIOCYC 3.930E-3 4.875E-2
2.265E-1
2.279E-1
 1 7
3 1470921 Aryl hydrocarbon receptor signalling BioSystems: REACTOME 4.490E-3 4.875E-2
2.265E-1
2.604E-1
 1 8
4 1268698 Folding of actin by CCT/TriC BioSystems: REACTOME 5.610E-3 4.875E-2
2.265E-1
3.254E-1
 1 10
5 1268758 ATF6 (ATF6-alpha) activates chaperone genes BioSystems: REACTOME 6.170E-3 4.875E-2
2.265E-1
3.579E-1
 1 11
6 1270422 HSF1 activation BioSystems: REACTOME 6.729E-3 4.875E-2
2.265E-1
3.903E-1
 1 12
7 1268757 ATF6 (ATF6-alpha) activates chaperones BioSystems: REACTOME 7.288E-3 4.875E-2
2.265E-1
4.227E-1
 1 13
8 1269205 Trafficking and processing of endosomal TLR BioSystems: REACTOME 7.847E-3 4.875E-2
2.265E-1
4.551E-1
 1 14
9 1270088 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) BioSystems: REACTOME 8.405E-3 4.875E-2
2.265E-1
4.875E-1
 1 15
10 1270424 Attenuation phase BioSystems: REACTOME 8.405E-3 4.875E-2
2.265E-1
4.875E-1
 1 15
Show 5 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 1410 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 27353360 The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Pubmed 7.561E-15 1.066E-11 8.346E-11 1.066E-11 5 21
2 22304920 PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Pubmed 3.785E-13 2.669E-10 2.089E-9 5.337E-10 6 136
3 28581483 Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Pubmed 6.833E-12 3.212E-9 2.514E-8 9.635E-9 7 495
4 20159553 Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Pubmed 4.521E-10 1.275E-7 9.980E-7 6.375E-7 3 7
5 23431407 Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels. Pubmed 7.233E-10 1.275E-7 9.980E-7 1.020E-6 3 8
6 27580824 Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Pubmed 7.233E-10 1.275E-7 9.980E-7 1.020E-6 3 8
7 25202009 A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. Pubmed 7.233E-10 1.275E-7 9.980E-7 1.020E-6 3 8
8 22315411 Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. Pubmed 7.233E-10 1.275E-7 9.980E-7 1.020E-6 3 8
9 29127155 Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients. Pubmed 1.085E-9 1.530E-7 1.197E-6 1.530E-6 3 9
10 26804907 Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Pubmed 1.085E-9 1.530E-7 1.197E-6 1.530E-6 3 9
11 19875381 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Pubmed 1.227E-9 1.573E-7 1.232E-6 1.731E-6 4 61
12 20029029 Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Pubmed 4.310E-9 5.065E-7 3.965E-6 6.077E-6 4 83
13 25036637 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Pubmed 1.069E-8 1.160E-6 9.079E-6 1.508E-5 5 326
14 22504172 Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Pubmed 1.470E-8 1.480E-6 1.159E-5 2.073E-5 3 20
15 14532270 A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. Pubmed 1.715E-8 1.612E-6 1.262E-5 2.418E-5 3 21
16 27483141 Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction. Pubmed 2.964E-8 2.612E-6 2.045E-5 4.179E-5 3 25
17 23349634 A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Pubmed 4.112E-8 3.410E-6 2.670E-5 5.797E-5 4 145
18 17010336 2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex. Pubmed 1.851E-7 1.450E-5 1.135E-4 2.610E-4 2 3
19 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 3.049E-7 2.263E-5 1.771E-4 4.299E-4 4 239
20 20159978 Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. Pubmed 3.701E-7 2.406E-5 1.883E-4 5.218E-4 2 4
21 22729780 Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. Pubmed 3.701E-7 2.406E-5 1.883E-4 5.218E-4 2 4
22 28366632 Inhibition of N-glycan processing modulates the network of EDEM3 interactors. Pubmed 3.754E-7 2.406E-5 1.883E-4 5.293E-4 3 57
23 25499913 AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics. Pubmed 3.958E-7 2.426E-5 1.900E-4 5.581E-4 3 58
24 24366813 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Pubmed 4.961E-7 2.899E-5 2.269E-4 6.995E-4 4 270
25 18388150 Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Pubmed 6.167E-7 2.899E-5 2.269E-4 8.696E-4 2 5
26 9148915 Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. Pubmed 6.167E-7 2.899E-5 2.269E-4 8.696E-4 2 5
27 19996313 Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. Pubmed 6.167E-7 2.899E-5 2.269E-4 8.696E-4 2 5
28 20704274 Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP. Pubmed 6.167E-7 2.899E-5 2.269E-4 8.696E-4 2 5
29 18285346 GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity. Pubmed 6.167E-7 2.899E-5 2.269E-4 8.696E-4 2 5
30 9727490 Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Pubmed 6.167E-7 2.899E-5 2.269E-4 8.696E-4 2 5
31 20959453 CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. Pubmed 9.250E-7 3.952E-5 3.094E-4 1.304E-3 2 6
32 9261129 Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. Pubmed 9.250E-7 3.952E-5 3.094E-4 1.304E-3 2 6
33 24462205 Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors. Pubmed 9.250E-7 3.952E-5 3.094E-4 1.304E-3 2 6
34 29053956 Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Pubmed 1.130E-6 4.686E-5 3.669E-4 1.593E-3 4 332
35 19135240 Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Pubmed 1.218E-6 4.906E-5 3.841E-4 1.717E-3 3 84
36 22079093 Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Pubmed 1.657E-6 5.660E-5 4.431E-4 2.336E-3 3 93
37 22824801 C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
38 19254810 The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
39 10811660 Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
40 15456869 Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
41 11809754 HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
42 10642522 Quantitative assessment of complex formation of nuclear-receptor accessory proteins. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
43 23482560 Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. Pubmed 1.726E-6 5.660E-5 4.431E-4 2.434E-3 2 8
44 20618441 CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates. Pubmed 2.219E-6 6.988E-5 5.471E-4 3.129E-3 2 9
45 25147182 Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 2.230E-6 6.988E-5 5.471E-4 3.145E-3 4 394
46 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 2.298E-6 7.045E-5 5.515E-4 3.241E-3 4 397
47 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 2.391E-6 7.174E-5 5.617E-4 3.372E-3 4 401
48 11413142 Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. Pubmed 2.773E-6 8.147E-5 6.378E-4 3.911E-3 2 10
49 24999758 Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Pubmed 3.011E-6 8.664E-5 6.783E-4 4.245E-3 4 425
50 22354994 Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. Pubmed 3.847E-6 1.085E-4 8.494E-4 5.425E-3 3 123
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 1050 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FLCN FLCN interactions 7.528E-12 7.905E-9 5.956E-8 7.905E-9 5 37
2 int:ATF2 ATF2 interactions 8.372E-10 4.395E-7 3.312E-6 8.791E-7 6 227
3 int:KCNQ4 KCNQ4 interactions 7.258E-9 2.312E-6 1.742E-5 7.621E-6 3 8
4 int:SOD1 SOD1 interactions 8.808E-9 2.312E-6 1.742E-5 9.248E-6 6 336
5 int:KLHL34 KLHL34 interactions 2.137E-8 3.753E-6 2.827E-5 2.243E-5 3 11
6 int:HSP90AB1 HSP90AB1 interactions 2.144E-8 3.753E-6 2.827E-5 2.252E-5 6 390
7 int:AHSA1 AHSA1 interactions 2.852E-8 4.278E-6 3.223E-5 2.994E-5 5 185
8 int:SLC6A4 SLC6A4 interactions 4.709E-8 6.181E-6 4.657E-5 4.945E-5 3 14
9 int:HSD17B10 HSD17B10 interactions 1.989E-7 2.321E-5 1.748E-4 2.089E-4 5 273
10 int:PACRG PACRG interactions 2.966E-7 3.114E-5 2.346E-4 3.114E-4 3 25
11 int:PTGES3 PTGES3 interactions 4.224E-7 4.032E-5 3.038E-4 4.436E-4 4 121
12 int:CDC37L1 CDC37L1 interactions 5.228E-7 4.574E-5 3.446E-4 5.489E-4 3 30
13 int:HSPE1 HSPE1 interactions 6.174E-7 4.987E-5 3.757E-4 6.483E-4 4 133
14 int:DLD DLD interactions 1.051E-6 7.880E-5 5.937E-4 1.103E-3 5 382
15 int:NOS2 NOS2 interactions 1.140E-6 7.977E-5 6.010E-4 1.197E-3 4 155
16 int:AHCYL1 AHCYL1 interactions 1.326E-6 8.704E-5 6.558E-4 1.393E-3 4 161
17 int:STIP1 STIP1 interactions 3.148E-6 1.944E-4 1.465E-3 3.305E-3 4 200
18 int:DNM1L DNM1L interactions 3.406E-6 1.957E-4 1.475E-3 3.576E-3 4 204
19 int:PHOSPHO1 PHOSPHO1 interactions 3.542E-6 1.957E-4 1.475E-3 3.719E-3 3 56
20 int:PPID PPID interactions 4.150E-6 2.179E-4 1.642E-3 4.358E-3 3 59
21 int:EDEM3 EDEM3 interactions 5.566E-6 2.783E-4 2.097E-3 5.844E-3 3 65
22 int:TCF3 TCF3 interactions 7.041E-6 3.361E-4 2.532E-3 7.393E-3 4 245
23 int:CDC37 CDC37 interactions 9.180E-6 4.191E-4 3.158E-3 9.639E-3 4 262
24 int:ABHD15 ABHD15 interactions 1.032E-5 4.333E-4 3.265E-3 1.083E-2 2 9
25 int:PNPLA5 PNPLA5 interactions 1.032E-5 4.333E-4 3.265E-3 1.083E-2 2 9
26 int:PSMA3 PSMA3 interactions 1.389E-5 5.610E-4 4.227E-3 1.459E-2 4 291
27 int:CCT2 CCT2 interactions 1.447E-5 5.625E-4 4.238E-3 1.519E-2 4 294
28 int:HSPA1A HSPA1A interactions 1.526E-5 5.628E-4 4.240E-3 1.602E-2 4 298
29 int:KPNA4 KPNA4 interactions 1.587E-5 5.628E-4 4.240E-3 1.667E-2 3 92
30 int:CCT3 CCT3 interactions 1.608E-5 5.628E-4 4.240E-3 1.688E-2 4 302
31 int:FKBP4 FKBP4 interactions 1.693E-5 5.736E-4 4.322E-3 1.778E-2 3 94
32 int:FNIP2 FNIP2 interactions 1.890E-5 6.013E-4 4.530E-3 1.984E-2 2 12
33 int:CLCN1 CLCN1 interactions 1.890E-5 6.013E-4 4.530E-3 1.984E-2 2 12
34 int:RIPK4 RIPK4 interactions 2.225E-5 6.336E-4 4.774E-3 2.336E-2 4 328
35 int:NOX5 NOX5 interactions 2.233E-5 6.336E-4 4.774E-3 2.344E-2 2 13
36 int:DNAI2 DNAI2 interactions 2.233E-5 6.336E-4 4.774E-3 2.344E-2 2 13
37 int:SLC12A3 SLC12A3 interactions 2.233E-5 6.336E-4 4.774E-3 2.344E-2 2 13
38 int:RCN1 RCN1 interactions 2.429E-5 6.711E-4 5.056E-3 2.550E-2 3 106
39 int:TRIM14 TRIM14 interactions 2.533E-5 6.742E-4 5.080E-3 2.659E-2 4 339
40 int:AMBRA1 AMBRA1 interactions 2.569E-5 6.742E-4 5.080E-3 2.697E-2 3 108
41 int:DNAJB1 DNAJB1 interactions 2.714E-5 6.950E-4 5.236E-3 2.849E-2 3 110
42 int:HDAC4 HDAC4 interactions 3.001E-5 7.503E-4 5.653E-3 3.151E-2 4 354
43 int:HSPA4 HSPA4 interactions 3.348E-5 7.990E-4 6.020E-3 3.515E-2 4 364
44 int:FKBP5 FKBP5 interactions 3.348E-5 7.990E-4 6.020E-3 3.516E-2 3 118
45 int:PPP5C PPP5C interactions 3.977E-5 9.281E-4 6.992E-3 4.176E-2 3 125
46 int:TCTN1 TCTN1 interactions 4.073E-5 9.298E-4 7.005E-3 4.277E-2 3 126
47 int:HSPH1 HSPH1 interactions 4.472E-5 9.982E-4 7.521E-3 4.695E-2 3 130
48 int:U2AF2 U2AF2 interactions 4.563E-5 9.982E-4 7.521E-3 4.791E-2 4 394
49 int:DNAJC7 DNAJC7 interactions 4.680E-5 1.003E-3 7.556E-3 4.914E-2 3 132
50 int:MTCH2 MTCH2 interactions 5.697E-5 1.196E-3 9.014E-3
5.982E-2
 3 141
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15q13-q14 15q13-q14 2.885E-4 2.885E-3 8.449E-3 2.885E-3 1 1
2 12q24.2-q24.3 12q24.2-q24.3 5.769E-4 2.885E-3 8.449E-3 5.769E-3 1 2
3 14q24 14q24 3.169E-3 1.056E-2 3.094E-2 3.169E-2 1 11
4 11q13.5 11q13.5 6.617E-3 1.553E-2 4.548E-2
6.617E-2
 1 23
5 12q24.13 12q24.13 7.763E-3 1.553E-2 4.548E-2
7.763E-2
 1 27
6 12q15 12q15 9.481E-3 1.580E-2 4.628E-2
9.481E-2
 1 33
7 2q33.1 2q33.1 1.490E-2 1.863E-2
5.456E-2
1.490E-1
 1 52
8 12q13.3 12q13.3 1.490E-2 1.863E-2
5.456E-2
1.490E-1
 1 52
9 11q13 11q13 3.381E-2 3.757E-2
1.100E-1
3.381E-1
 1 119
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 34 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TTCNRGNNNNTTC V$HSF Q6 TTCNRGNNNNTTC V$HSF Q6 9.680E-8 3.291E-6 1.355E-5 3.291E-6 4 117
2 RGAANNTTC V$HSF1 01 RGAANNTTC V$HSF1 01 8.328E-6 1.416E-4 5.830E-4 2.831E-4 4 355
3 TTCYRGAA UNKNOWN TTCYRGAA UNKNOWN 1.429E-4 1.620E-3 6.670E-3 4.859E-3 3 241
4 V$HSF Q6 V$HSF Q6 2.332E-3 1.982E-2
8.162E-2
7.928E-2
 2 152

12: Gene Family [Display Chart] 8 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 587 Chaperonins genenames.org 1.771E-5 1.240E-4 3.215E-4 1.240E-4 2 15
2 769 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 1.082E-3 3.786E-3 9.817E-3 7.572E-3 2 115
3 586 Heat shock 90kDa proteins genenames.org 2.197E-3 4.918E-3 1.275E-2 1.538E-2 1 5
4 365 U-box domain containing genenames.org 3.074E-3 4.918E-3 1.275E-2 2.152E-2 1 7
5 925 Granins genenames.org 3.513E-3 4.918E-3 1.275E-2 2.459E-2 1 8
6 692 Protein disulfide isomerases genenames.org 9.198E-3 1.073E-2 2.783E-2
6.439E-2
 1 21
7 739 Serpin peptidase inhibitors genenames.org 1.616E-2 1.616E-2 4.189E-2
1.131E-1
 1 37
Show 2 more annotations

13: Coexpression [Display Chart] 10 input genes in category / 1137 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.258E-11 5.979E-8 4.552E-7 5.979E-8 6 187
2 M18854 Genes down-regulated in BJUB cells (B-lymphoma) in response to rapamycin (sirolimus) [PubChem=6610346] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.688E-10 1.528E-7 1.163E-6 3.056E-7 6 245
3 M1667 Genes down-regulated after heat shock in peripheral lympocytes from old donors, compared to those from the young ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.111E-8 8.001E-6 6.092E-5 2.400E-5 3 14
4 M18806 Down-regulated genes in Calu3 cells (non-small cell lung cancer, NSCLC) resistant to gemcitabine [PubChem=3461] which became up-regulated in response to bexarotene [PubChem=82146]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.508E-7 3.435E-5 2.615E-4 1.714E-4 4 122
5 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.511E-7 3.435E-5 2.615E-4 1.718E-4 5 337
6 M4369 Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.092E-6 1.774E-4 1.351E-3 1.242E-3 4 200
7 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v6.0) 1.092E-6 1.774E-4 1.351E-3 1.242E-3 4 200
8 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.463E-6 1.203E-3 9.158E-3 9.622E-3 4 335
9 M1865 Up-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.306E-5 1.650E-3 1.257E-2 1.485E-2 4 374
10 12216074-Table2 Human Bladder Kassem02 20genes RadioSensitiveVsResistant GeneSigDB 3.181E-5 3.075E-3 2.341E-2 3.617E-2 2 20
11 12216074-Table3 Human Bladder Kassem02 20genes CellLine GeneSigDB 3.181E-5 3.075E-3 2.341E-2 3.617E-2 2 20
12 M5075 Cluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [GeneID=4609] and down-regulated by the combination of MYC and serum. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.689E-5 3.075E-3 2.341E-2 4.194E-2 3 159
13 M3000 Genes up-regulated in B lymphocytes with ZFX [GeneID=7543] knockout: control versus stimulated by anti-IgM for 2h. MSigDB C7: Immunologic Signatures (v6.0) 3.972E-5 3.075E-3 2.341E-2 4.517E-2 3 163
14 16217257-Table2 Human StemCell Bandres05 28genes GeneSigDB 5.867E-5 3.075E-3 2.341E-2
6.671E-2
 2 27
15 20145155-Table2 Human StemCell Lottaz10 28genes GeneSigDB 6.317E-5 3.075E-3 2.341E-2
7.183E-2
 2 28
16 M9475 Genes down-regulated in CD8 T cells: naïve versus effectors. MSigDB C7: Immunologic Signatures (v6.0) 7.194E-5 3.075E-3 2.341E-2
8.179E-2
 3 199
17 M5432 Genes up-regulated in comparison of mast cells versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 7.194E-5 3.075E-3 2.341E-2
8.179E-2
 3 199
18 M4523 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
19 M5382 Genes down-regulated in comparison of memory CD4 [GeneID=920] T cells versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
20 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
21 M7840 Genes down-regulated in resting T reg versus T conv cells. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
22 M7531 Genes down-regulated in stimulated by anti-CD3 double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
23 M6068 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 [GeneID=7040] and IL-12 (6h) versus untreated (6h). MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
24 M4645 Genes up-regulated in comparison of fetal conventional T cells versus adult conventional T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
25 M4589 Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 5. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
26 M5379 Genes down-regulated in comparison of memory CD4 [GeneID=920] T cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
27 M9900 Genes up-regulated in dendritic cells: untreated versus 2h after infection of Leishmania major. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 3.075E-3 2.341E-2
8.302E-2
 3 200
28 M262 Genes discriminating responses to sodium arsenite [PubChem=26435] from other stresses. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.301E-5 3.777E-3 2.876E-2
1.058E-1
 3 217
29 16790086-tableW1 Rat Liver Perez-Carreon06 290genes GeneSigDB 1.091E-4 4.277E-3 3.257E-2
1.240E-1
 3 229
30 15172037-Table1 Mouse Tissue Hayashi04 69genes GeneSigDB 1.434E-4 5.436E-3 4.139E-2
1.631E-1
 2 42
31 M4077 Genes identified by method 2 as coordinately down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.914E-4 7.020E-3
5.345E-2
2.176E-1
 3 277
32 19555670-Table3b Human Lymphoma Cassinelli09 59genes GeneSigDB 2.037E-4 7.098E-3
5.404E-2
2.316E-1
 2 50
33 M16975 Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.060E-4 7.098E-3
5.404E-2
2.342E-1
 3 284
34 M10236 Genes up-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.541E-4 8.499E-3
6.471E-2
2.890E-1
 3 305
35 16265353-SuppTable2 Human Bladder Aaboe05 86genes GeneSigDB 4.347E-4 1.412E-2
1.075E-1
4.942E-1
 2 73
36 M3737 Genes up-regulated in OV-90 cells (ovarian cancer) exposed to ascites which inhibited invasion. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.482E-4 1.731E-2
1.318E-1
6.233E-1
 2 82
37 12969976-Table1 Human Myeloma Munshi04 93genes GeneSigDB 6.745E-4 2.053E-2
1.563E-1
7.669E-1
 2 91
38 M4752 Genes down-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders). MSigDB C2: CGP Curated Gene Sets (v6.0) 6.893E-4 2.053E-2
1.563E-1
7.838E-1
 2 92
39 M15565 Up-regulated at 24 h following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 7.043E-4 2.053E-2
1.563E-1
8.008E-1
 2 93
40 M17723 Genes down-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.463E-4 2.393E-2
1.822E-1
9.622E-1
 2 102
41 M19360 Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 11. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.629E-4 2.393E-2
1.822E-1
9.811E-1
 2 103
42 12631704-table1 Human StemCell Qi03 534genes GeneSigDB 9.380E-4 2.539E-2
1.933E-1
1.000E0
 3 477
43 M1696 Genes up-regulated in the Ad/AH cells (adenocarcinoma) engineered to stably express the Epstein-Barr virus (EBV) gene EBNA1. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.832E-4 2.600E-2
1.979E-1
1.000E0
 2 110
44 M5451 Survival signature genes defined in adjacent liver tissue: genes correlated with good survival of hepatocellular carcinoma (HCC) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.037E-3 2.680E-2
2.040E-1
1.000E0
 2 113
45 19328798-SuppTable2 Human Colon Fritzmann09 123genes GeneSigDB 1.074E-3 2.713E-2
2.066E-1
1.000E0
 2 115
46 M19630 Up-regulated at any timepoint following infection of primary human foreskin fibroblasts with CMV MSigDB C2: CGP Curated Gene Sets (v6.0) 1.168E-3 2.888E-2
2.199E-1
1.000E0
 2 120
47 M2080 Genes up-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.307E-3 3.162E-2
2.407E-1
1.000E0
 2 127
48 M11672 Genes from the blue module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.475E-3 3.245E-2
2.471E-1
1.000E0
 2 135
49 16964388-SuppTable1 Human Ovarian Bachvarov06 155genes GeneSigDB 1.562E-3 3.245E-2
2.471E-1
1.000E0
 2 139
50 M10633 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.652E-3 3.245E-2
2.471E-1
1.000E0
 2 143
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 10 input genes in category / 1132 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour PapRCC IF-U/Kidney Tumour PapRCC IF15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour PapRCC IF-U/Kidney Tumour PapRCC IF15 Adult, Development, and Cancer types 1.075E-6 1.216E-3 9.257E-3 1.216E-3 4 188
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R15 Adult, Development, and Cancer types 2.710E-6 1.534E-3 1.167E-2 3.067E-3 3 63
3 Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ MultiLin Top 200 Genes Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ MultiLin Top 200 Genes 6.971E-6 2.245E-3 1.708E-2 7.891E-3 4 301
4 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Subtype CD34+ MKP Top 200 Genes Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Subtype CD34+ MKP Top 200 Genes 7.932E-6 2.245E-3 1.708E-2 8.979E-3 4 311
5 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC10 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC10 Top 200 Genes 1.278E-5 2.894E-3 2.202E-2 1.447E-2 4 351
6 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Top 200 Human Cell Atlas Human Cell Atlas Megakaryocytic Megakaryocytic Top 200 2.310E-5 4.358E-3 3.316E-2 2.615E-2 4 408
7 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 500 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 500 FaceBase_RNAseq 4.961E-5 5.136E-3 3.908E-2
5.615E-2
 4 496
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U26 Adult, Development, and Cancer types 5.931E-5 5.136E-3 3.908E-2
6.714E-2
 3 176
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Tumour PapRCC Ureter epithelium/Kidney Tumour PapRCC N15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Tumour PapRCC Ureter epithelium/Kidney Tumour PapRCC N15 Adult, Development, and Cancer types 6.879E-5 5.136E-3 3.908E-2
7.787E-2
 3 185
10 Kidney10XCellRanger Six2TGC E14 Endo Endo Overall Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Overall Top 200 Genes 6.879E-5 5.136E-3 3.908E-2
7.787E-2
 3 185
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour PapRCC Mast cell/Kidney Tumour PapRCC IN15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Mast cell/Kidney Tumour PapRCC Mast cell/Kidney Tumour PapRCC IN15 Adult, Development, and Cancer types 7.102E-5 5.136E-3 3.908E-2
8.040E-2
 3 187
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour VHL RCC Endothelium/Kidney Tumour VHL RCC N7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour VHL RCC Endothelium/Kidney Tumour VHL RCC N7 Adult, Development, and Cancer types 7.330E-5 5.136E-3 3.908E-2
8.298E-2
 3 189
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasmacytoid DC/Kidney Normal-Cortex Wilms Plasmacytoid DC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Plasmacytoid DC/Kidney Normal-Cortex Wilms Plasmacytoid DC Adult, Development, and Cancer types 7.563E-5 5.136E-3 3.908E-2
8.562E-2
 3 191
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Medulla Wilms IF-U/Kidney Normal-Medulla Wilms IF14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Medulla Wilms IF-U/Kidney Normal-Medulla Wilms IF14 Adult, Development, and Cancer types 7.801E-5 5.136E-3 3.908E-2
8.831E-2
 3 193
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Normal fetal kidney MNP2 Adult, Development, and Cancer types 7.801E-5 5.136E-3 3.908E-2
8.831E-2
 3 193
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IN-U/Ureter Normal RCC IN-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IN-U/Ureter Normal RCC IN-U Adult, Development, and Cancer types 7.921E-5 5.136E-3 3.908E-2
8.967E-2
 3 194
17 Human Cell Atlas Human Cell Atlas Immune Immune Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Overall Top 200 Genes 8.043E-5 5.136E-3 3.908E-2
9.105E-2
 3 195
18 Human Cell Atlas Human Cell Atlas Erythro Erythro Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Overall Top 200 Genes 8.166E-5 5.136E-3 3.908E-2
9.244E-2
 3 196
19 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC1 Top 200 Genes 8.671E-5 5.166E-3 3.931E-2
9.815E-2
 3 200
20 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC9 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC9 Top 200 Genes 1.639E-4 9.262E-3
7.048E-2
1.855E-1
 3 248
21 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes 1.718E-4 9.262E-3
7.048E-2
1.945E-1
 3 252
22 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Erythroblast Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Erythroblast Top 200 Genes 2.344E-4 1.206E-2
9.177E-2
2.653E-1
 3 280
23 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Early-Erythroblast Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Early-Erythroblast Top 200 Genes 2.572E-4 1.266E-2
9.634E-2
2.912E-1
 3 289
24 Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ HSC-cycle Top 200 Genes Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ HSC-cycle Top 200 Genes 2.787E-4 1.315E-2
1.000E-1
3.155E-1
 3 297
25 Kidney10XCellRanger Six2TGC TSC1 E14 Stroma Stroma Subtype E14-Six2TGC Tsc1-Stroma2-C4-KC8 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Stroma Stroma Subtype E14-Six2TGC Tsc1-Stroma2-C4-KC8 Top 200 Genes 2.928E-4 1.326E-2
1.009E-1
3.314E-1
 3 302
26 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ pre-T Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ pre-T Top 200 Genes 3.161E-4 1.376E-2
1.047E-1
3.578E-1
 3 310
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour PapRCC PT-U/Kidney Tumour PapRCC PT15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour PapRCC PT-U/Kidney Tumour PapRCC PT15 Adult, Development, and Cancer types 3.407E-4 1.407E-2
1.071E-1
3.857E-1
 2 61
28 Kidney10XCellRanger Six2TGC TSC1 E14 Stroma Stroma Subtype E14-Six2TGC Tsc1-Stroma2-C5-KC8 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Stroma Stroma Subtype E14-Six2TGC Tsc1-Stroma2-C5-KC8 Top 200 Genes 3.566E-4 1.407E-2
1.071E-1
4.037E-1
 3 323
29 Kidney10XCellRanger Six2TGC TSC1 P0 UB UB Top 200 Kidney10XCellRanger Six2TGC TSC1 P0 UB UB Top 200 3.697E-4 1.407E-2
1.071E-1
4.185E-1
 3 327
30 Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ LMPP Top 200 Genes Human Cell Atlas Human Cell Atlas HSC HSC Subtype CD34+ LMPP Top 200 Genes 3.730E-4 1.407E-2
1.071E-1
4.222E-1
 3 328
31 Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Duodenum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enterocyte progenitor Enterocyte progenitor Subtype progenitor Duodenum Top 200 Genes Mouse Cell Atlas 3.933E-4 1.436E-2
1.093E-1
4.453E-1
 3 334
32 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes 4.073E-4 1.441E-2
1.096E-1
4.611E-1
 3 338
33 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype CD34+ ERP-Early Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype CD34+ ERP-Early Top 200 Genes 4.398E-4 1.442E-2
1.097E-1
4.979E-1
 3 347
34 BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Peptidergic Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Peptidergic Top 200 Genes BrainMap 4.398E-4 1.442E-2
1.097E-1
4.979E-1
 3 347
35 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype CD34+ ERP Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype CD34+ ERP Top 200 Genes 4.473E-4 1.442E-2
1.097E-1
5.063E-1
 3 349
36 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype CD34+ MEP Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype CD34+ MEP Top 200 Genes 4.586E-4 1.442E-2
1.097E-1
5.192E-1
 3 352
37 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC7 Top 200 Genes 5.018E-4 1.535E-2
1.168E-1
5.680E-1
 3 363
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal-Cortex Wilms Fetus other/Kidney Normal-Cortex Wilms F9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Fetus other/Kidney Normal-Cortex Wilms Fetus other/Kidney Normal-Cortex Wilms F9 Adult, Development, and Cancer types 5.568E-4 1.659E-2
1.262E-1
6.303E-1
 2 78
39 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/mid-fetal/IMM h Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/mid-fetal/IMM h Fetal, Development 6.003E-4 1.742E-2
1.326E-1
6.795E-1
 2 81
40 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c6 Top 200 Genes 10X Human 68K PBMC CD8+ Cytotoxic T Subtype CD8+ Cytotoxic T-CD8+ Cytotoxic T c6 Top 200 Genes 6.279E-4 1.777E-2
1.352E-1
7.107E-1
 3 392
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U Adult, Development, and Cancer types 7.080E-4 1.955E-2
1.487E-1
8.015E-1
 2 88
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U Adult, Development, and Cancer types 8.948E-4 2.356E-2
1.792E-1
1.000E0
 2 99
43 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal VHL RCC EN-B/Kidney Normal VHL RCC EN16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal VHL RCC EN-B/Kidney Normal VHL RCC EN16 Adult, Development, and Cancer types 8.948E-4 2.356E-2
1.792E-1
1.000E0
 2 99
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex Wilms Proliferating NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Proliferating NK cell/Kidney Normal-Cortex Wilms Proliferating NK cell Adult, Development, and Cancer types 1.083E-3 2.774E-2
2.111E-1
1.000E0
 2 109
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal fetal kidney EN-A Adult, Development, and Cancer types 1.103E-3 2.774E-2
2.111E-1
1.000E0
 2 110
46 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 1.157E-3 2.848E-2
2.167E-1
1.000E0
 3 484
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U6 Adult, Development, and Cancer types 2.369E-3 3.479E-2
2.648E-1
1.000E0
 2 162
48 6mo cortical organoids wt 6mo cortical organoids wt Subtype mature neuron 2 s8 mature neuron 2 Subtype mature neuron 2 s8 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype mature neuron 2 s8 mature neuron 2 Subtype mature neuron 2 s8 Top 100 Genes 2.456E-3 3.479E-2
2.648E-1
1.000E0
 2 165
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell Adult, Development, and Cancer types 2.485E-3 3.479E-2
2.648E-1
1.000E0
 2 166
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal RCC IF-U/Kidney Normal RCC IF16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal RCC IF-U/Kidney Normal RCC IF16 Adult, Development, and Cancer types 2.544E-3 3.479E-2
2.648E-1
1.000E0
 2 168
Show 45 more annotations

15: Computational [Display Chart] 9 input genes in category / 111 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4634 MODULE 299 Genes in the cancer module 299. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.776E-11 5.301E-9 2.805E-8 5.301E-9 5 35
2 M13419 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.746E-6 6.663E-5 3.525E-4 1.938E-4 5 276
3 M4563 MODULE 355 Protein folding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.801E-6 6.663E-5 3.525E-4 1.999E-4 3 29
4 M446 MORF HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.027E-5 2.851E-4 1.509E-3 1.140E-3 4 174
5 M4 MORF FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.118E-5 4.702E-4 2.488E-3 2.351E-3 3 65
6 M6530 MORF UNG Neighborhood of UNG MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.392E-5 6.185E-4 3.273E-3 3.765E-3 3 76
7 M18698 MORF EIF3S2 Neighborhood of EIF3S2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.901E-5 6.185E-4 3.273E-3 4.330E-3 4 244
8 M7895 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.412E-5 7.908E-4 4.184E-3 7.117E-3 4 277
9 M11406 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.412E-5 7.908E-4 4.184E-3 7.117E-3 4 277
10 M7309 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.507E-4 1.673E-3 8.852E-3 1.673E-2 4 345
11 M3370 MODULE 155 Genes in the cancer module 155. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.121E-4 1.961E-3 1.038E-2 2.355E-2 2 25
12 M382 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.188E-4 1.961E-3 1.038E-2 2.429E-2 3 142
13 M19205 MODULE 245 Genes in the cancer module 245. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.297E-4 1.961E-3 1.038E-2 2.550E-2 2 26
14 M18640 GNF2 MLH1 Neighborhood of MLH1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.041E-4 4.789E-3 2.534E-2
6.705E-2
 2 42
15 M2705 MORF ACP1 Neighborhood of ACP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.910E-4 5.114E-3 2.706E-2
7.670E-2
 3 210
16 M18997 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.471E-4 6.280E-3 3.323E-2
1.051E-1
 3 234
17 M18524 MORF GMPS Neighborhood of GMPS MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.619E-4 6.280E-3 3.323E-2
1.068E-1
 2 53
18 M11080 MORF HDAC1 Neighborhood of HDAC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.202E-3 7.410E-3 3.921E-2
1.334E-1
 3 254
19 M18002 MORF CSNK2B Neighborhood of CSNK2B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.710E-3 9.989E-3
5.286E-2
1.898E-1
 3 287
20 M218 GNF2 PA2G4 Neighborhood of PA2G4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.125E-3 1.179E-2
6.239E-2
2.358E-1
 2 79
21 M14632 MORF PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.342E-3 1.238E-2
6.551E-2
2.600E-1
 2 83
22 M7487 GNF2 RAN Neighborhood of RAN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.512E-3 1.268E-2
6.707E-2
2.789E-1
 2 86
23 M1109 MORF UBE2N Neighborhood of UBE2N MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.993E-3 1.445E-2
7.644E-2
3.323E-1
 2 94
24 M1104 MORF RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.514E-3 1.625E-2
8.600E-2
3.901E-1
 2 102
25 M4246 MORF EIF3S6 Neighborhood of EIF3S6 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.910E-3 2.180E-2
1.153E-1
5.450E-1
 2 121
26 M6545 MORF FBL Neighborhood of FBL MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.432E-3 2.746E-2
1.453E-1
7.139E-1
 2 139
27 M13545 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.456E-3 3.065E-2
1.622E-1
8.276E-1
 2 150
28 M18610 MORF PPP1CC Neighborhood of PPP1CC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.859E-3 3.512E-2
1.858E-1
9.834E-1
 2 164
29 M7181 MORF PPP1CA Neighborhood of PPP1CA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.388E-3 3.593E-2
1.901E-1
1.000E0
 2 169
30 M19884 MORF ANP32B Neighborhood of ANP32B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.260E-2 4.574E-2
2.420E-1
1.000E0
 2 197
31 M6479 MODULE 105 Genes in the cancer module 105. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.297E-2 4.574E-2
2.420E-1
1.000E0
 2 200
32 M8613 MODULE 519 Oxidoreductases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.338E-2 4.574E-2
2.420E-1
1.000E0
 1 15
33 M15222 MORF AATF Neighborhood of AATF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.360E-2 4.574E-2
2.420E-1
1.000E0
 2 205
Show 28 more annotations

16: MicroRNA [Display Chart] 10 input genes in category / 304 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6789-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.486E-6 2.276E-3 1.433E-2 2.276E-3 2 30
2 hsa-miR-6722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.772E-4 2.872E-2
1.808E-1
8.428E-2
 2 181
3 hsa-miR-1909-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.834E-4 2.872E-2
1.808E-1
8.615E-2
 2 183
4 hsa-miR-1207-3p:PITA hsa-miR-1207-3p:PITA TOP PITA 6.414E-4 3.987E-2
2.510E-1
1.950E-1
 2 276
5 hsa-miR-409-5p:mirSVR highEffct hsa-miR-409-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.599E-4 3.987E-2
2.510E-1
2.006E-1
 2 280
6 hsa-miR-1247:mirSVR lowEffct hsa-miR-1247:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.869E-4 3.987E-2
2.510E-1
2.392E-1
 2 306
7 hsa-miR-572:mirSVR lowEffct hsa-miR-572:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.044E-3 4.207E-2
2.649E-1
3.174E-1
 2 353
8 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 1.297E-3 4.207E-2
2.649E-1
3.943E-1
 2 394
9 hsa-miR-744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.584E-3 4.207E-2
2.649E-1
4.815E-1
 2 436
10 hsa-miR-103-as:mirSVR highEffct hsa-miR-103-as:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.745E-3 4.207E-2
2.649E-1
5.305E-1
 2 458
11 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 1.937E-3 4.207E-2
2.649E-1
5.890E-1
 2 483
12 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 1.937E-3 4.207E-2
2.649E-1
5.890E-1
 2 483
13 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 1.937E-3 4.207E-2
2.649E-1
5.890E-1
 2 483
14 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 1.937E-3 4.207E-2
2.649E-1
5.890E-1
 2 483
15 hsa-miR-6125:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.421E-3 4.767E-2
3.001E-1
1.000E0
 1 32
16 hsa-miR-4750-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.248E-3 4.767E-2
3.001E-1
1.000E0
 1 38
17 hsa-miR-4278:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.074E-3 4.767E-2
3.001E-1
1.000E0
 1 44
18 hsa-miR-7158-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.487E-3 4.767E-2
3.001E-1
1.000E0
 1 47
19 hsa-miR-6846-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.487E-3 4.767E-2
3.001E-1
1.000E0
 1 47
20 hsa-miR-6859-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.625E-3 4.767E-2
3.001E-1
1.000E0
 1 48
21 GCTGAGT,MIR-512-5P:MSigDB GCTGAGT,MIR-512-5P:MSigDB MSigDB 6.763E-3 4.767E-2
3.001E-1
1.000E0
 1 49
22 hsa-miR-6824-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.900E-3 4.767E-2
3.001E-1
1.000E0
 1 50
23 hsa-miR-5580-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.038E-3 4.767E-2
3.001E-1
1.000E0
 1 51
24 hsa-miR-3140-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.175E-3 4.767E-2
3.001E-1
1.000E0
 1 52
25 hsa-miR-99b-5p:Functional MTI Functional MTI miRTarbase 7.313E-3 4.767E-2
3.001E-1
1.000E0
 1 53
26 CCATCCA,MIR-432:MSigDB CCATCCA,MIR-432:MSigDB MSigDB 7.313E-3 4.767E-2
3.001E-1
1.000E0
 1 53
27 hsa-miR-7154-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.000E-3 4.767E-2
3.001E-1
1.000E0
 1 58
28 AGTCAGC,MIR-345:MSigDB AGTCAGC,MIR-345:MSigDB MSigDB 8.000E-3 4.767E-2
3.001E-1
1.000E0
 1 58
29 hsa-miR-370-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.000E-3 4.767E-2
3.001E-1
1.000E0
 1 58
30 hsa-miR-6741-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.412E-3 4.767E-2
3.001E-1
1.000E0
 1 61
31 hsa-miR-4450:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.962E-3 4.767E-2
3.001E-1
1.000E0
 1 65
32 hsa-miR-1180-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.236E-3 4.767E-2
3.001E-1
1.000E0
 1 67
33 hsa-miR-1178-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.511E-3 4.767E-2
3.001E-1
1.000E0
 1 69
34 hsa-miR-3668:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.648E-3 4.767E-2
3.001E-1
1.000E0
 1 70
35 hsa-miR-892b:Functional MTI Functional MTI miRTarbase 9.785E-3 4.767E-2
3.001E-1
1.000E0
 1 71
36 hsa-miR-5002-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.923E-3 4.767E-2
3.001E-1
1.000E0
 1 72
37 hsa-miR-4721:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.923E-3 4.767E-2
3.001E-1
1.000E0
 1 72
38 hsa-miR-4712-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.006E-2 4.767E-2
3.001E-1
1.000E0
 1 73
39 hsa-miR-125b-1*:mirSVR highEffct hsa-miR-125b-1*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.020E-2 4.767E-2
3.001E-1
1.000E0
 1 74
40 hsa-miR-6813-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.020E-2 4.767E-2
3.001E-1
1.000E0
 1 74
41 hsa-miR-638:mirSVR highEffct hsa-miR-638:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.061E-2 4.767E-2
3.001E-1
1.000E0
 1 77
42 hsa-miR-379:PITA hsa-miR-379:PITA TOP PITA 1.061E-2 4.767E-2
3.001E-1
1.000E0
 1 77
43 hsa-miR-6085:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.075E-2 4.767E-2
3.001E-1
1.000E0
 1 78
44 hsa-miR-6504-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.102E-2 4.767E-2
3.001E-1
1.000E0
 1 80
45 hsa-miR-369-5p:mirSVR highEffct hsa-miR-369-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.116E-2 4.767E-2
3.001E-1
1.000E0
 1 81
46 hsa-miR-3064-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 4.767E-2
3.001E-1
1.000E0
 1 81
47 hsa-miR-433-3p:Functional MTI Functional MTI miRTarbase 1.116E-2 4.767E-2
3.001E-1
1.000E0
 1 81
48 hsa-miR-493:PITA hsa-miR-493:PITA TOP PITA 1.129E-2 4.767E-2
3.001E-1
1.000E0
 1 82
49 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.143E-2 4.767E-2
3.001E-1
1.000E0
 1 83
50 hsa-miR-187-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.157E-2 4.767E-2
3.001E-1
1.000E0
 1 84
Show 45 more annotations

17: Drug [Display Chart] 10 input genes in category / 1813 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D006820 Hyaluronic Acid CTD 1.022E-8 1.853E-5 1.497E-4 1.853E-5 5 194
2 ctd:C535076 7-tosylcyclonovobiocic acid CTD 5.174E-7 6.160E-5 4.977E-4 9.381E-4 2 3
3 ctd:C535075 4-tosylcyclonovobiocic acid CTD 5.174E-7 6.160E-5 4.977E-4 9.381E-4 2 3
4 6187 UP geldanamycin; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.594E-7 6.160E-5 4.977E-4 1.014E-3 4 167
5 1056 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 5.867E-7 6.160E-5 4.977E-4 1.064E-3 4 169
6 1631 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.007E-7 6.160E-5 4.977E-4 1.089E-3 4 170
7 1064 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.294E-7 6.160E-5 4.977E-4 1.141E-3 4 172
8 1063 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.592E-7 6.160E-5 4.977E-4 1.195E-3 4 174
9 1044 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.592E-7 6.160E-5 4.977E-4 1.195E-3 4 174
10 1651 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.592E-7 6.160E-5 4.977E-4 1.195E-3 4 174
11 1006 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.745E-7 6.160E-5 4.977E-4 1.223E-3 4 175
12 1653 UP geldanamycin; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.745E-7 6.160E-5 4.977E-4 1.223E-3 4 175
13 1643 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.059E-7 6.160E-5 4.977E-4 1.280E-3 4 177
14 2685 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Up 7.219E-7 6.160E-5 4.977E-4 1.309E-3 4 178
15 1005 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 7.383E-7 6.160E-5 4.977E-4 1.338E-3 4 179
16 5578 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.718E-7 6.160E-5 4.977E-4 1.399E-3 4 181
17 2688 UP geldanamycin; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Up 7.890E-7 6.160E-5 4.977E-4 1.430E-3 4 182
18 6946 UP geldanamycin; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 8.064E-7 6.160E-5 4.977E-4 1.462E-3 4 183
19 1206 UP 17-AAG; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 8.064E-7 6.160E-5 4.977E-4 1.462E-3 4 183
20 1051 UP 17-DMAG; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 8.242E-7 6.160E-5 4.977E-4 1.494E-3 4 184
21 6985 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 8.242E-7 6.160E-5 4.977E-4 1.494E-3 4 184
22 1228 UP geldanamycin; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 8.605E-7 6.160E-5 4.977E-4 1.560E-3 4 186
23 1226 UP 17-AAG; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 8.605E-7 6.160E-5 4.977E-4 1.560E-3 4 186
24 432 UP 17-AAG; Up 200; 1uM; PC3; HG-U133A Broad Institute CMAP Up 8.605E-7 6.160E-5 4.977E-4 1.560E-3 4 186
25 1218 UP 17-AAG; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 8.792E-7 6.160E-5 4.977E-4 1.594E-3 4 187
26 611 UP geldanamycin; Up 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Up 9.173E-7 6.160E-5 4.977E-4 1.663E-3 4 189
27 1225 UP 17-AAG; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 9.173E-7 6.160E-5 4.977E-4 1.663E-3 4 189
28 521 UP 17-AAG; Up 200; 1uM; ssMCF7; HG-U133A Broad Institute CMAP Up 1.039E-6 6.541E-5 5.285E-4 1.884E-3 4 195
29 1927 DN Verapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; PC3; HG-U133A Broad Institute CMAP Down 1.061E-6 6.541E-5 5.285E-4 1.923E-3 4 196
30 1944 DN Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HG-U133A Broad Institute CMAP Down 1.082E-6 6.541E-5 5.285E-4 1.962E-3 4 197
31 ctd:C031280 pyrazole CTD 1.774E-6 1.037E-4 8.382E-4 3.216E-3 4 223
32 CID000004795 AC1L1IZ2 Stitch 6.065E-6 3.436E-4 2.777E-3 1.100E-2 4 304
33 ctd:C002741 N-nitrosomorpholine CTD 9.548E-6 5.246E-4 4.239E-3 1.731E-2 4 341
34 CID000003460 geldanamicin Stitch 1.360E-5 7.250E-4 5.858E-3 2.465E-2 4 373
35 CID000038479 acumen Stitch 2.338E-5 1.211E-3 9.786E-3 4.239E-2 2 17
36 ctd:C472349 oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine CTD 2.677E-5 1.348E-3 1.089E-2 4.854E-2 3 141
37 ctd:C110172 BHTOH-QM CTD 2.938E-5 1.433E-3 1.158E-2
5.327E-2
 2 19
38 2448 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 3.285E-5 1.433E-3 1.158E-2
5.956E-2
 3 151
39 ctd:C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 3.425E-5 1.433E-3 1.158E-2
6.210E-2
 4 472
40 ctd:D016627 Oxidopamine CTD 4.127E-5 1.433E-3 1.158E-2
7.482E-2
 3 163
41 1066 UP geldanamycin; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 4.357E-5 1.433E-3 1.158E-2
7.900E-2
 3 166
42 2927 UP Sanguinarine [2447-54-3]; Up 200; 12uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.436E-5 1.433E-3 1.158E-2
8.043E-2
 3 167
43 2691 UP 15d-PGJ2; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.596E-5 1.433E-3 1.158E-2
8.333E-2
 3 169
44 1167 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.678E-5 1.433E-3 1.158E-2
8.481E-2
 3 170
45 2673 UP 17-DMAG; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.013E-5 1.433E-3 1.158E-2
9.089E-2
 3 174
46 864 UP geldanamycin; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 5.013E-5 1.433E-3 1.158E-2
9.089E-2
 3 174
47 6177 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Up 5.013E-5 1.433E-3 1.158E-2
9.089E-2
 3 174
48 5215 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.013E-5 1.433E-3 1.158E-2
9.089E-2
 3 174
49 1231 UP 15d-PGJ2; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.099E-5 1.433E-3 1.158E-2
9.245E-2
 3 175
50 5222 UP 17-AAG; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.099E-5 1.433E-3 1.158E-2
9.245E-2
 3 175
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 269 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:610504 PRETERM PREMATURE RUPTURE OF THE MEMBRANES; PPROM OMIM 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
2 cv:CN186321 Spinocerebellar ataxia, autosomal recessive 16 Clinical Variations 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
3 cv:C3151211 Osteogenesis imperfecta type 10 Clinical Variations 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
4 C4014261 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 16 DisGeNET Curated 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
5 C3151211 OSTEOGENESIS IMPERFECTA, TYPE X DisGeNET Curated 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
6 cv:C0729264 Preterm premature rupture of membranes Clinical Variations 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
7 C0729264 Preterm premature rupture of membranes (disorder) DisGeNET Curated 6.171E-4 2.371E-2
1.464E-1
1.660E-1
 1 1
8 C4025186 T-cell lymphoma/leukemia DisGeNET BeFree 1.234E-3 4.149E-2
2.561E-1
3.319E-1
 1 2
Show 3 more annotations