Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc259_11, positive side

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1: GO: Molecular Function [Display Chart] 11 input genes in category / 46 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008236 serine-type peptidase activity 4.808E-16 1.237E-14 5.465E-14 2.211E-14 9 242
2 GO:0017171 serine hydrolase activity 5.380E-16 1.237E-14 5.465E-14 2.475E-14 9 245
3 GO:0004252 serine-type endopeptidase activity 4.365E-14 6.694E-13 2.956E-12 2.008E-12 8 215
4 GO:0004175 endopeptidase activity 1.884E-11 2.166E-10 9.569E-10 8.666E-10 8 457
5 GO:0048406 nerve growth factor binding 6.623E-6 6.093E-5 2.691E-4 3.047E-4 2 7
6 GO:0043121 neurotrophin binding 1.732E-5 1.328E-4 5.866E-4 7.969E-4 2 11
7 GO:0034189 very-low-density lipoprotein particle binding 1.179E-3 7.745E-3 3.421E-2
5.422E-2
 1 2
8 GO:0070326 very-low-density lipoprotein particle receptor binding 2.356E-3 1.355E-2
5.983E-2
1.084E-1
 1 4
9 GO:0019838 growth factor binding 3.023E-3 1.545E-2
6.825E-2
1.391E-1
 2 142
10 GO:0019871 sodium channel inhibitor activity 3.532E-3 1.625E-2
7.176E-2
1.625E-1
 1 6
11 GO:0034190 apolipoprotein receptor binding 4.120E-3 1.723E-2
7.609E-2
1.895E-1
 1 7
12 GO:0050897 cobalt ion binding 4.707E-3 1.804E-2
7.969E-2
2.165E-1
 1 8
13 GO:0004185 serine-type carboxypeptidase activity 8.224E-3 2.542E-2
1.123E-1
3.783E-1
 1 14
14 GO:0030547 receptor inhibitor activity 8.224E-3 2.542E-2
1.123E-1
3.783E-1
 1 14
15 GO:0042043 neurexin family protein binding 8.809E-3 2.542E-2
1.123E-1
4.052E-1
 1 15
16 GO:0030169 low-density lipoprotein particle binding 9.394E-3 2.542E-2
1.123E-1
4.321E-1
 1 16
17 GO:0034185 apolipoprotein binding 9.394E-3 2.542E-2
1.123E-1
4.321E-1
 1 16
18 GO:0050750 low-density lipoprotein particle receptor binding 1.056E-2 2.564E-2
1.132E-1
4.859E-1
 1 18
19 GO:0042277 peptide binding 1.113E-2 2.564E-2
1.132E-1
5.120E-1
 2 278
20 GO:0070008 serine-type exopeptidase activity 1.115E-2 2.564E-2
1.132E-1
5.127E-1
 1 19
21 GO:0070325 lipoprotein particle receptor binding 1.348E-2 2.848E-2
1.258E-1
6.200E-1
 1 23
22 GO:0033218 amide binding 1.362E-2 2.848E-2
1.258E-1
6.265E-1
 2 309
23 GO:0071813 lipoprotein particle binding 1.522E-2 2.908E-2
1.284E-1
7.003E-1
 1 26
24 GO:0071814 protein-lipid complex binding 1.522E-2 2.908E-2
1.284E-1
7.003E-1
 1 26
25 GO:0004181 metallocarboxypeptidase activity 1.581E-2 2.908E-2
1.284E-1
7.270E-1
 1 27
26 GO:0017080 sodium channel regulator activity 1.987E-2 3.515E-2
1.552E-1
9.138E-1
 1 34
27 GO:0008200 ion channel inhibitor activity 2.276E-2 3.793E-2
1.675E-1
1.000E0
 1 39
28 GO:0016248 channel inhibitor activity 2.391E-2 3.793E-2
1.675E-1
1.000E0
 1 41
29 GO:0004180 carboxypeptidase activity 2.391E-2 3.793E-2
1.675E-1
1.000E0
 1 41
30 GO:0030545 receptor regulator activity 2.966E-2 4.548E-2
2.009E-1
1.000E0
 1 51
31 GO:0008235 metalloexopeptidase activity 3.081E-2 4.572E-2
2.019E-1
1.000E0
 1 53
32 GO:0043621 protein self-association 3.253E-2 4.676E-2
2.065E-1
1.000E0
 1 56
Show 27 more annotations

2: GO: Biological Process [Display Chart] 11 input genes in category / 290 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016486 peptide hormone processing 7.180E-18 2.082E-15 1.301E-14 2.082E-15 7 32
2 GO:0016485 protein processing 1.024E-14 1.485E-12 9.281E-12 2.970E-12 9 338
3 GO:0051604 protein maturation 2.108E-14 2.038E-12 1.273E-11 6.114E-12 9 366
4 GO:0042445 hormone metabolic process 6.227E-12 4.515E-10 2.821E-9 1.806E-9 7 208
5 GO:0032455 nerve growth factor processing 6.130E-10 3.556E-8 2.222E-7 1.778E-7 3 4
6 GO:0034230 enkephalin processing 3.172E-7 1.314E-5 8.211E-5 9.198E-5 2 2
7 GO:0032902 nerve growth factor production 3.172E-7 1.314E-5 8.211E-5 9.198E-5 2 2
8 GO:0030070 insulin processing 9.513E-7 3.448E-5 2.155E-4 2.759E-4 2 3
9 GO:0032898 neurotrophin production 1.902E-6 6.128E-5 3.829E-4 5.516E-4 2 4
10 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process 3.169E-6 8.354E-5 5.220E-4 9.190E-4 2 5
11 GO:0032802 low-density lipoprotein particle receptor catabolic process 3.169E-6 8.354E-5 5.220E-4 9.190E-4 2 5
12 GO:2000644 regulation of receptor catabolic process 8.864E-6 2.142E-4 1.339E-3 2.571E-3 2 8
13 GO:1901142 insulin metabolic process 1.424E-5 3.176E-4 1.985E-3 4.129E-3 2 10
14 GO:0016540 protein autoprocessing 2.465E-5 5.107E-4 3.191E-3 7.149E-3 2 13
15 GO:0032799 low-density lipoprotein receptor particle metabolic process 2.875E-5 5.559E-4 3.474E-3 8.338E-3 2 14
16 GO:0032801 receptor catabolic process 8.693E-5 1.576E-3 9.845E-3 2.521E-2 2 24
17 GO:0006465 signal peptide processing 9.445E-5 1.611E-3 1.007E-2 2.739E-2 2 25
18 GO:0032903 regulation of nerve growth factor production 5.907E-4 8.157E-3
5.097E-2
1.713E-1
 1 1
19 GO:0032904 negative regulation of nerve growth factor production 5.907E-4 8.157E-3
5.097E-2
1.713E-1
 1 1
20 GO:0019082 viral protein processing 5.907E-4 8.157E-3
5.097E-2
1.713E-1
 1 1
21 GO:0034231 islet amyloid polypeptide processing 5.907E-4 8.157E-3
5.097E-2
1.713E-1
 1 1
22 GO:0003002 regionalization 1.140E-3 1.370E-2
8.561E-2
3.306E-1
 3 370
23 GO:0032900 negative regulation of neurotrophin production 1.181E-3 1.370E-2
8.561E-2
3.425E-1
 1 2
24 GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process 1.181E-3 1.370E-2
8.561E-2
3.425E-1
 1 2
25 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process 1.181E-3 1.370E-2
8.561E-2
3.425E-1
 1 2
26 GO:2000645 negative regulation of receptor catabolic process 1.771E-3 1.771E-2
1.107E-1
5.136E-1
 1 3
27 GO:0032899 regulation of neurotrophin production 1.771E-3 1.771E-2
1.107E-1
5.136E-1
 1 3
28 GO:2000173 negative regulation of branching morphogenesis of a nerve 1.771E-3 1.771E-2
1.107E-1
5.136E-1
 1 3
29 GO:0032911 negative regulation of transforming growth factor beta1 production 1.771E-3 1.771E-2
1.107E-1
5.136E-1
 1 3
30 GO:0010989 negative regulation of low-density lipoprotein particle clearance 2.361E-3 2.075E-2
1.296E-1
6.846E-1
 1 4
31 GO:0001920 negative regulation of receptor recycling 2.361E-3 2.075E-2
1.296E-1
6.846E-1
 1 4
32 GO:2000646 positive regulation of receptor catabolic process 2.361E-3 2.075E-2
1.296E-1
6.846E-1
 1 4
33 GO:0007354 zygotic determination of anterior/posterior axis, embryo 2.361E-3 2.075E-2
1.296E-1
6.846E-1
 1 4
34 GO:0007368 determination of left/right symmetry 2.552E-3 2.176E-2
1.360E-1
7.401E-1
 2 130
35 GO:0007389 pattern specification process 2.626E-3 2.176E-2
1.360E-1
7.617E-1
 3 495
36 GO:1900378 positive regulation of secondary metabolite biosynthetic process 2.950E-3 2.257E-2
1.410E-1
8.555E-1
 1 5
37 GO:0048023 positive regulation of melanin biosynthetic process 2.950E-3 2.257E-2
1.410E-1
8.555E-1
 1 5
38 GO:0009855 determination of bilateral symmetry 2.994E-3 2.257E-2
1.410E-1
8.681E-1
 2 141
39 GO:0009799 specification of symmetry 3.035E-3 2.257E-2
1.410E-1
8.802E-1
 2 142
40 GO:2000172 regulation of branching morphogenesis of a nerve 3.539E-3 2.566E-2
1.603E-1
1.000E0
 1 6
41 GO:0043112 receptor metabolic process 4.072E-3 2.721E-2
1.700E-1
1.000E0
 2 165
42 GO:0010985 negative regulation of lipoprotein particle clearance 4.128E-3 2.721E-2
1.700E-1
1.000E0
 1 7
43 GO:0002001 renin secretion into blood stream 4.128E-3 2.721E-2
1.700E-1
1.000E0
 1 7
44 GO:0071635 negative regulation of transforming growth factor beta production 4.128E-3 2.721E-2
1.700E-1
1.000E0
 1 7
45 GO:0003205 cardiac chamber development 4.416E-3 2.846E-2
1.778E-1
1.000E0
 2 172
46 GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure 4.716E-3 2.850E-2
1.781E-1
1.000E0
 1 8
47 GO:0048021 regulation of melanin biosynthetic process 4.716E-3 2.850E-2
1.781E-1
1.000E0
 1 8
48 GO:1900376 regulation of secondary metabolite biosynthetic process 4.716E-3 2.850E-2
1.781E-1
1.000E0
 1 8
49 GO:0032905 transforming growth factor beta1 production 5.305E-3 2.958E-2
1.849E-1
1.000E0
 1 9
50 GO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process 5.305E-3 2.958E-2
1.849E-1
1.000E0
 1 9
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 11 input genes in category / 51 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030133 transport vesicle 1.187E-6 4.214E-5 1.904E-4 6.054E-5 5 374
2 GO:0030141 secretory granule 1.653E-6 4.214E-5 1.904E-4 8.429E-5 5 400
3 GO:0005796 Golgi lumen 1.984E-5 3.373E-4 1.524E-3 1.012E-3 3 96
4 GO:0034774 secretory granule lumen 1.053E-3 8.407E-3 3.799E-2
5.370E-2
 2 85
5 GO:0030667 secretory granule membrane 1.154E-3 8.407E-3 3.799E-2
5.884E-2
 2 89
6 GO:1990667 PCSK9-AnxA2 complex 1.154E-3 8.407E-3 3.799E-2
5.885E-2
 1 2
7 GO:1990666 PCSK9-LDLR complex 1.154E-3 8.407E-3 3.799E-2
5.885E-2
 1 2
8 GO:0060205 cytoplasmic vesicle lumen 1.570E-3 9.588E-3 4.333E-2
8.009E-2
 2 104
9 GO:0031983 vesicle lumen 1.692E-3 9.588E-3 4.333E-2
8.629E-2
 2 108
10 GO:0043204 perikaryon 2.900E-3 1.479E-2
6.684E-2
1.479E-1
 2 142
11 GO:0030658 transport vesicle membrane 3.575E-3 1.658E-2
7.491E-2
1.823E-1
 2 158
12 GO:0032585 multivesicular body membrane 5.183E-3 2.033E-2
9.188E-2
2.643E-1
 1 9
13 GO:0031232 extrinsic component of external side of plasma membrane 5.183E-3 2.033E-2
9.188E-2
2.643E-1
 1 9
14 GO:0005770 late endosome 7.052E-3 2.569E-2
1.161E-1
3.596E-1
 2 224
15 GO:0030135 coated vesicle 8.122E-3 2.749E-2
1.242E-1
4.142E-1
 2 241
16 GO:0012510 trans-Golgi network transport vesicle membrane 8.625E-3 2.749E-2
1.242E-1
4.399E-1
 1 15
17 GO:0031045 dense core granule 9.197E-3 2.759E-2
1.247E-1
4.691E-1
 1 16
18 GO:0005769 early endosome 1.349E-2 3.695E-2
1.670E-1
6.878E-1
 2 314
19 GO:0002080 acrosomal membrane 1.377E-2 3.695E-2
1.670E-1
7.021E-1
 1 24
20 GO:0098857 membrane microdomain 1.595E-2 3.874E-2
1.751E-1
8.135E-1
 2 343
21 GO:0045121 membrane raft 1.595E-2 3.874E-2
1.751E-1
8.135E-1
 2 343
22 GO:0030140 trans-Golgi network transport vesicle 1.718E-2 3.983E-2
1.800E-1
8.763E-1
 1 30
Show 17 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 365 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 10 input genes in category / 586 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011189 small embryonic epiblast 4.596E-5 1.231E-2
8.558E-2
 2.693E-2 2 11
2 MP:0020579 abnormal pancreatic delta cell number 8.755E-5 1.231E-2
8.558E-2
5.131E-2
 2 15
3 MP:0009593 absent chorion 1.133E-4 1.231E-2
8.558E-2
6.638E-2
 2 17
4 MP:0005128 decreased adrenocorticotropin level 1.274E-4 1.231E-2
8.558E-2
7.464E-2
 2 18
5 MP:0005218 abnormal pancreatic delta cell morphology 1.274E-4 1.231E-2
8.558E-2
7.464E-2
 2 18
6 MP:0009170 abnormal pancreatic islet size 1.399E-4 1.231E-2
8.558E-2
8.196E-2
 3 112
7 MP:0012685 abnormal primitive streak elongation 1.580E-4 1.231E-2
8.558E-2
9.260E-2
 2 20
8 MP:0003972 decreased pituitary hormone level 1.892E-4 1.231E-2
8.558E-2
1.108E-1
 3 124
9 MP:0002696 decreased circulating glucagon level 1.919E-4 1.231E-2
8.558E-2
1.125E-1
 2 22
10 MP:0010736 abnormal extraembryonic ectoderm morphology 2.101E-4 1.231E-2
8.558E-2
1.231E-1
 2 23
11 MP:0003087 absent allantois 2.695E-4 1.316E-2
9.147E-2
1.579E-1
 2 26
12 MP:0005030 absent amnion 2.695E-4 1.316E-2
9.147E-2
1.579E-1
 2 26
13 MP:0002582 disorganized extraembryonic tissue 3.131E-4 1.411E-2
9.810E-2
1.835E-1
 2 28
14 MP:0005217 abnormal pancreatic beta cell morphology 3.517E-4 1.472E-2
1.023E-1
2.061E-1
 3 153
15 MP:0004179 transmission ratio distortion 6.103E-4 2.384E-2
1.657E-1
3.576E-1
 2 39
16 MP:0003966 abnormal adrenocorticotropin level 6.746E-4 2.471E-2
1.718E-1
3.953E-1
 2 41
17 MP:0002695 abnormal circulating glucagon level 7.771E-4 2.530E-2
1.759E-1
4.554E-1
 2 44
18 MP:0005491 pancreatic islet hyperplasia 7.771E-4 2.530E-2
1.759E-1
4.554E-1
 2 44
19 MP:0000644 dextrocardia 8.493E-4 2.582E-2
1.795E-1
4.977E-1
 2 46
20 MP:0005029 abnormal amnion morphology 9.247E-4 2.582E-2
1.795E-1
5.419E-1
 2 48
21 MP:0004732 decreased circulating gastrin level 9.657E-4 2.582E-2
1.795E-1
5.659E-1
 1 1
22 MP:0002836 abnormal chorion morphology 1.003E-3 2.582E-2
1.795E-1
5.879E-1
 2 50
23 MP:0005498 hyporesponsive to tactile stimuli 1.044E-3 2.582E-2
1.795E-1
6.115E-1
 2 51
24 MP:0003965 abnormal pituitary hormone level 1.057E-3 2.582E-2
1.795E-1
6.196E-1
 3 223
25 MP:0003934 abnormal pancreas development 1.127E-3 2.632E-2
1.829E-1
6.603E-1
 2 53
26 MP:0011095 embryonic lethality between implantation and placentation, complete penetrance 1.213E-3 2.632E-2
1.829E-1
7.108E-1
 2 55
27 MP:0005215 abnormal pancreatic islet morphology 1.277E-3 2.632E-2
1.829E-1
7.481E-1
 3 238
28 MP:0009165 abnormal endocrine pancreas morphology 1.292E-3 2.632E-2
1.829E-1
7.572E-1
 3 239
29 MP:0003339 decreased pancreatic beta cell number 1.302E-3 2.632E-2
1.829E-1
7.631E-1
 2 57
30 MP:0009171 enlarged pancreatic islets 1.539E-3 3.003E-2
2.088E-1
9.019E-1
 2 62
31 MP:0003968 abnormal growth hormone level 1.589E-3 3.003E-2
2.088E-1
9.310E-1
 2 63
32 MP:0006065 abnormal heart position or orientation 1.690E-3 3.094E-2
2.151E-1
9.905E-1
 2 65
33 MP:0002230 abnormal primitive streak formation 1.742E-3 3.094E-2
2.151E-1
1.000E0
 2 66
34 MP:0001433 polyphagia 2.070E-3 3.553E-2
2.470E-1
1.000E0
 2 72
35 MP:0000182 increased circulating LDL cholesterol level 2.127E-3 3.553E-2
2.470E-1
1.000E0
 2 73
36 MP:0003886 abnormal embryonic epiblast morphology 2.243E-3 3.553E-2
2.470E-1
1.000E0
 2 75
37 MP:0020578 abnormal pancreatic beta cell number 2.243E-3 3.553E-2
2.470E-1
1.000E0
 2 75
38 MP:0012103 abnormal bilaminar embryonic disk morphology 2.611E-3 4.027E-2
2.799E-1
1.000E0
 2 81
39 MP:0009706 absent midgut 2.895E-3 4.349E-2
3.023E-1
1.000E0
 1 3
40 MP:0004133 heterotaxia 3.074E-3 4.484E-2
3.117E-1
1.000E0
 2 88
41 MP:0002727 decreased circulating insulin level 3.726E-3 4.484E-2
3.117E-1
1.000E0
 3 346
42 MP:0001944 abnormal pancreas morphology 3.849E-3 4.484E-2
3.117E-1
1.000E0
 3 350
43 MP:0014109 increased pancreatic alpha cell proliferation 3.858E-3 4.484E-2
3.117E-1
1.000E0
 1 4
44 MP:0008953 abnormal pancreatic somatostatin secretion 3.858E-3 4.484E-2
3.117E-1
1.000E0
 1 4
45 MP:0008952 abnormal pancreatic delta cell physiology 3.858E-3 4.484E-2
3.117E-1
1.000E0
 1 4
46 MP:0010329 abnormal lipoprotein level 3.880E-3 4.484E-2
3.117E-1
1.000E0
 3 351
47 MP:0010330 abnormal circulating lipoprotein level 3.880E-3 4.484E-2
3.117E-1
1.000E0
 3 351
48 MP:0003119 abnormal digestive system development 3.950E-3 4.484E-2
3.117E-1
1.000E0
 2 100
49 MP:0005293 impaired glucose tolerance 4.168E-3 4.484E-2
3.117E-1
1.000E0
 3 360
50 MP:0012079 abnormal spinal reflex 4.186E-3 4.484E-2
3.117E-1
1.000E0
 2 103
Show 45 more annotations

6: Domain [Display Chart] 11 input genes in category / 58 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00136 SUBTILASE ASP PROSITE 1.975E-26 2.863E-25 1.330E-24 1.145E-24 8 10
2 PS00137 SUBTILASE HIS PROSITE 1.975E-26 2.863E-25 1.330E-24 1.145E-24 8 10
3 PS00138 SUBTILASE SER PROSITE 1.975E-26 2.863E-25 1.330E-24 1.145E-24 8 10
4 IPR015500 Peptidase S8 subtilisin-rel InterPro 1.975E-26 2.863E-25 1.330E-24 1.145E-24 8 10
5 IPR000209 Peptidase S8/S53 dom InterPro 7.240E-26 5.999E-25 2.787E-24 4.199E-24 8 11
6 3.40.50.200 - Gene3D 7.240E-26 5.999E-25 2.787E-24 4.199E-24 8 11
7 PF00082 Peptidase S8 Pfam 7.240E-26 5.999E-25 2.787E-24 4.199E-24 8 11
8 PF01483 P proprotein Pfam 2.055E-24 9.933E-24 4.615E-23 1.192E-22 7 7
9 IPR032815 S8 pro-domain InterPro 2.055E-24 9.933E-24 4.615E-23 1.192E-22 7 7
10 3.30.70.850 - Gene3D 2.055E-24 9.933E-24 4.615E-23 1.192E-22 7 7
11 PF16470 S8 pro-domain Pfam 2.055E-24 9.933E-24 4.615E-23 1.192E-22 7 7
12 IPR002884 PrprotnconvertsP InterPro 2.055E-24 9.933E-24 4.615E-23 1.192E-22 7 7
13 IPR009020 Propept inh InterPro 1.066E-23 4.755E-23 2.209E-22 6.181E-22 8 17
14 IPR022398 Peptidase S8 His-AS InterPro 7.396E-23 2.860E-22 1.329E-21 4.290E-21 7 9
15 IPR023828 Peptidase S8 Ser-AS InterPro 7.396E-23 2.860E-22 1.329E-21 4.290E-21 7 9
16 IPR023827 Peptidase S8 Asp-AS InterPro 7.698E-21 2.791E-20 1.297E-19 4.465E-19 6 6
17 2.60.120.260 - Gene3D 3.308E-15 1.128E-14 5.243E-14 1.918E-13 7 73
18 IPR008979 Galactose-bd-like InterPro 2.070E-14 6.669E-14 3.099E-13 1.200E-12 7 94
19 IPR006212 Furin repeat InterPro 1.960E-10 5.683E-10 2.640E-9 1.137E-8 4 18
20 SM00261 FU SMART 1.960E-10 5.683E-10 2.640E-9 1.137E-8 4 18
21 IPR009030 Growth fac rcpt InterPro 1.459E-6 4.028E-6 1.872E-5 8.460E-5 4 156
22 IPR032778 GF recep IV InterPro 4.695E-6 1.184E-5 5.501E-5 2.723E-4 2 6
23 PF14843 GF recep IV Pfam 4.695E-6 1.184E-5 5.501E-5 2.723E-4 2 6
24 PF08686 PLAC Pfam 2.841E-5 6.866E-5 3.190E-4 1.648E-3 2 14
25 PS50900 PLAC PROSITE 5.330E-5 1.189E-4 5.525E-4 3.091E-3 2 19
26 IPR010909 PLAC InterPro 5.330E-5 1.189E-4 5.525E-4 3.091E-3 2 19
27 PF12177 Proho convert Pfam 5.871E-4 1.099E-3 5.104E-3 3.405E-2 1 1
28 PF05922 Inhibitor I9 Pfam 5.871E-4 1.099E-3 5.104E-3 3.405E-2 1 1
29 IPR010259 S8pro/Inhibitor I9 InterPro 5.871E-4 1.099E-3 5.104E-3 3.405E-2 1 1
30 IPR022005 Proho convert InterPro 5.871E-4 1.099E-3 5.104E-3 3.405E-2 1 1
31 3.30.70.80 - Gene3D 5.871E-4 1.099E-3 5.104E-3 3.405E-2 1 1
32 PF00801 PKD Pfam 4.103E-3 7.437E-3 3.456E-2
2.380E-1
 1 7
33 SM00089 PKD SMART 5.273E-3 8.995E-3 4.179E-2
3.058E-1
 1 9
34 IPR022409 PKD/Chitinase dom InterPro 5.273E-3 8.995E-3 4.179E-2
3.058E-1
 1 9
35 PS50093 PKD PROSITE 6.441E-3 1.010E-2 4.691E-2
3.736E-1
 1 11
36 2.60.40.670 - Gene3D 6.441E-3 1.010E-2 4.691E-2
3.736E-1
 1 11
37 IPR000601 PKD dom InterPro 6.441E-3 1.010E-2 4.691E-2
3.736E-1
 1 11
38 IPR014766 CarboxyPept regulatory dom InterPro 7.608E-3 1.132E-2
5.257E-2
4.413E-1
 1 13
39 2.60.40.1120 - Gene3D 7.608E-3 1.132E-2
5.257E-2
4.413E-1
 1 13
40 SM00181 EGF SMART 8.063E-3 1.169E-2
5.432E-2
4.677E-1
 2 236
41 IPR000742 EGF-like dom InterPro 9.010E-3 1.275E-2
5.922E-2
5.226E-1
 2 250
42 IPR008969 CarboxyPept-like regulatory InterPro 9.939E-3 1.373E-2
6.377E-2
5.765E-1
 1 17
43 SM00631 Zn pept SMART 1.052E-2 1.419E-2
6.593E-2
6.102E-1
 1 18
44 PS00133 CARBOXYPEPT ZN 2 PROSITE 1.110E-2 1.463E-2
6.800E-2
6.439E-1
 1 19
45 PS00132 CARBOXYPEPT ZN 1 PROSITE 1.168E-2 1.506E-2
6.997E-2
6.776E-1
 1 20
46 IPR000834 Peptidase M14 InterPro 1.343E-2 1.657E-2
7.698E-2
7.787E-1
 1 23
47 PF00246 Peptidase M14 Pfam 1.343E-2 1.657E-2
7.698E-2
7.787E-1
 1 23
48 IPR011641 Tyr-kin ephrin A/B rcpt-like InterPro 1.458E-2 1.726E-2
8.021E-2
8.459E-1
 1 25
49 SM01411 Ephrin rec like SMART 1.458E-2 1.726E-2
8.021E-2
8.459E-1
 1 25
Show 44 more annotations

7: Pathway [Display Chart] 10 input genes in category / 60 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00003 Alzheimer disease-amyloid secretase pathway PantherDB 3.303E-12 1.982E-10 9.276E-10 1.982E-10 6 65
2 P00004 Alzheimer disease-presenilin pathway PantherDB 9.971E-11 2.991E-9 1.400E-8 5.983E-9 6 113
3 1269444 NGF processing BioSystems: REACTOME 1.492E-9 2.984E-8 1.397E-7 8.953E-8 3 4
4 PW:0000365 melanocortin system Pathway Ontology 4.465E-8 6.698E-7 3.134E-6 2.679E-6 3 10
5 1270005 Lipoprotein metabolism BioSystems: REACTOME 2.350E-7 2.821E-6 1.320E-5 1.410E-5 4 74
6 1268747 Insulin processing BioSystems: REACTOME 1.210E-6 1.037E-5 4.853E-5 7.258E-5 3 28
7 1270006 Chylomicron-mediated lipid transport BioSystems: REACTOME 1.210E-6 1.037E-5 4.853E-5 7.258E-5 3 28
8 1270002 Lipid digestion, mobilization, and transport BioSystems: REACTOME 1.390E-6 1.042E-5 4.879E-5 8.340E-5 4 115
9 1268746 Peptide hormone metabolism BioSystems: REACTOME 4.368E-5 2.912E-4 1.363E-3 2.621E-3 3 91
10 1270343 Signaling by NODAL BioSystems: REACTOME 1.210E-4 7.257E-4 3.396E-3 7.257E-3 2 21
11 1269089 Synthesis and processing of ENV and VPU BioSystems: REACTOME 8.032E-4 4.381E-3 2.050E-2 4.819E-2 1 1
12 1457791 Formation of the cornified envelope BioSystems: REACTOME 1.401E-3 6.832E-3 3.197E-2
8.406E-2
 2 71
13 P00019 Endothelin signaling pathway PantherDB 1.480E-3 6.832E-3 3.197E-2
8.882E-2
 2 73
14 PW:0000583 orexin/hypocretin signaling Pathway Ontology 3.209E-3 1.375E-2
6.437E-2
1.926E-1
 1 4
15 PW:0000359 altered energy homeostasis Pathway Ontology 4.010E-3 1.504E-2
7.038E-2
2.406E-1
 1 5
16 PW:0000366 altered melanocortin system Pathway Ontology 4.010E-3 1.504E-2
7.038E-2
2.406E-1
 1 5
17 1269443 Signalling by NGF BioSystems: REACTOME 5.678E-3 2.004E-2
9.379E-2
3.407E-1
 3 483
18 138084 Glypican 3 network BioSystems: Pathway Interaction Database 6.409E-3 2.024E-2
9.472E-2
3.846E-1
 1 8
19 PW:0000540 obesity disease Pathway Ontology 6.409E-3 2.024E-2
9.472E-2
3.846E-1
 1 8
20 1268706 Removal of aminoterminal propeptides from gamma-carboxylated proteins BioSystems: REACTOME 8.006E-3 2.310E-2
1.081E-1
4.804E-1
 1 10
21 P04395 Vasopressin synthesis PantherDB 8.803E-3 2.310E-2
1.081E-1
5.282E-1
 1 11
22 1268703 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins BioSystems: REACTOME 8.803E-3 2.310E-2
1.081E-1
5.282E-1
 1 11
23 PW:0000363 leptin system Pathway Ontology 9.600E-3 2.310E-2
1.081E-1
5.760E-1
 1 12
24 1427853 VLDLR internalisation and degradation BioSystems: REACTOME 9.600E-3 2.310E-2
1.081E-1
5.760E-1
 1 12
25 1269154 Uptake and function of anthrax toxins BioSystems: REACTOME 1.040E-2 2.310E-2
1.081E-1
6.238E-1
 1 13
26 1268752 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) BioSystems: REACTOME 1.040E-2 2.310E-2
1.081E-1
6.238E-1
 1 13
27 1269086 Assembly Of The HIV Virion BioSystems: REACTOME 1.040E-2 2.310E-2
1.081E-1
6.238E-1
 1 13
28 1268753 Peptide hormone biosynthesis BioSystems: REACTOME 1.119E-2 2.398E-2
1.122E-1
6.715E-1
 1 14
29 1457790 Keratinization BioSystems: REACTOME 1.208E-2 2.500E-2
1.170E-1
7.251E-1
 2 214
30 1269534 Pre-NOTCH Processing in Golgi BioSystems: REACTOME 1.437E-2 2.843E-2
1.330E-1
8.622E-1
 1 18
31 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 1.480E-2 2.843E-2
1.330E-1
8.880E-1
 2 238
32 1268748 Synthesis, secretion, and deacylation of Ghrelin BioSystems: REACTOME 1.516E-2 2.843E-2
1.330E-1
9.097E-1
 1 19
33 1268751 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) BioSystems: REACTOME 1.595E-2 2.901E-2
1.358E-1
9.573E-1
 1 20
34 1427851 VLDL interactions BioSystems: REACTOME 1.833E-2 3.142E-2
1.470E-1
1.000E0
 1 23
35 1268750 Incretin synthesis, secretion, and inactivation BioSystems: REACTOME 1.833E-2 3.142E-2
1.470E-1
1.000E0
 1 23
36 1270008 LDL-mediated lipid transport BioSystems: REACTOME 1.912E-2 3.186E-2
1.491E-1
1.000E0
 1 24
37 83096 Maturity onset diabetes of the young BioSystems: KEGG 2.070E-2 3.356E-2
1.571E-1
1.000E0
 1 26
38 1269144 Uptake and actions of bacterial toxins BioSystems: REACTOME 2.463E-2 3.889E-2
1.820E-1
1.000E0
 1 31
39 1270258 Activation of Matrix Metalloproteinases BioSystems: REACTOME 2.620E-2 4.031E-2
1.886E-1
1.000E0
 1 33
40 1269524 TGF-beta receptor signaling activates SMADs BioSystems: REACTOME 2.699E-2 4.048E-2
1.894E-1
1.000E0
 1 34
41 1268702 Gamma carboxylation, hypusine formation and arylsulfatase activation BioSystems: REACTOME 3.090E-2 4.522E-2
2.116E-1
1.000E0
 1 39
42 1270259 Collagen degradation BioSystems: REACTOME 3.246E-2 4.637E-2
2.170E-1
1.000E0
 1 41
43 1270251 Elastic fibre formation BioSystems: REACTOME 3.324E-2 4.638E-2
2.171E-1
1.000E0
 1 42
44 83095 Type I diabetes mellitus BioSystems: KEGG 3.402E-2 4.639E-2
2.171E-1
1.000E0
 1 43
45 137954 Arf6 trafficking events BioSystems: Pathway Interaction Database 3.480E-2 4.640E-2
2.171E-1
1.000E0
 1 44
46 1269531 Pre-NOTCH Expression and Processing BioSystems: REACTOME 3.713E-2 4.843E-2
2.266E-1
1.000E0
 1 47
Show 41 more annotations

8: Pubmed [Display Chart] 11 input genes in category / 1823 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21805237 The proprotein convertases, 20 years later. Pubmed 1.323E-29 4.825E-27 3.901E-26 2.412E-26 8 9
2 21805236 The prohormone theory and the proprotein convertases: it is all about serendipity. Pubmed 1.323E-29 4.825E-27 3.901E-26 2.412E-26 8 9
3 23775089 The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. Pubmed 1.323E-29 4.825E-27 3.901E-26 2.412E-26 8 9
4 18343183 The activation and physiological functions of the proprotein convertases. Pubmed 1.323E-29 4.825E-27 3.901E-26 2.412E-26 8 9
5 22679642 The biology and therapeutic targeting of the proprotein convertases. Pubmed 1.323E-29 4.825E-27 3.901E-26 2.412E-26 8 9
6 16163737 Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development. Pubmed 6.616E-29 2.010E-26 1.625E-25 1.206E-25 8 10
7 10409610 Proteolytic processing in the secretory pathway. Pubmed 1.404E-26 3.199E-24 2.587E-23 2.559E-23 7 7
8 7819324 The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Pubmed 1.404E-26 3.199E-24 2.587E-23 2.559E-23 7 7
9 9885250 Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. Pubmed 1.123E-25 2.275E-23 1.839E-22 2.047E-22 7 8
10 8940009 Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines. Pubmed 1.072E-22 1.954E-20 1.580E-19 1.954E-19 6 6
11 10037747 Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. Pubmed 7.504E-22 1.244E-19 1.006E-18 1.368E-18 6 7
12 8698813 SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. Pubmed 9.003E-21 1.368E-18 1.106E-17 1.641E-17 6 9
13 20876279 Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst. Pubmed 5.361E-19 7.517E-17 6.078E-16 9.772E-16 6 15
14 9242664 Processing of prothyrotropin-releasing hormone by the family of prohormone convertases. Pubmed 6.824E-19 8.293E-17 6.706E-16 1.244E-15 5 5
15 1429684 The new enzymology of precursor processing endoproteases. Pubmed 6.824E-19 8.293E-17 6.706E-16 1.244E-15 5 5
16 9291583 Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation. Pubmed 4.094E-18 4.664E-16 3.771E-15 7.463E-15 5 6
17 9521771 Retroviral envelope glycoprotein processing: structural investigation of the cleavage site. Pubmed 3.723E-15 3.393E-13 2.744E-12 6.786E-12 4 4
18 10900462 The proprotein convertases furin and PACE4 play a significant role in tumor progression. Pubmed 3.723E-15 3.393E-13 2.744E-12 6.786E-12 4 4
19 10701998 Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Pubmed 3.723E-15 3.393E-13 2.744E-12 6.786E-12 4 4
20 18664504 Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7. Pubmed 3.723E-15 3.393E-13 2.744E-12 6.786E-12 4 4
21 11380615 Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates. Pubmed 1.861E-14 1.616E-12 1.306E-11 3.393E-11 4 5
22 7782070 Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. Pubmed 2.604E-13 2.158E-11 1.745E-10 4.748E-10 4 8
23 11063880 Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
24 17645548 PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
25 8995623 The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
26 1765368 Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region). Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
27 18096669 The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
28 22396549 Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
29 8262946 Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
30 18706454 Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
31 10050053 Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
32 12358783 Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
33 19339735 Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
34 18554181 Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
35 8670066 Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
36 21147780 In vivo evidence that furin from hepatocytes inactivates PCSK9. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
37 16912035 The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
38 11723118 Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains. Pubmed 1.777E-11 8.526E-10 6.894E-9 3.240E-8 3 3
39 12787574 Neurotrophin secretion: current facts and future prospects. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
40 8615794 Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
41 24101515 Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
42 16829522 CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
43 18245819 Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
44 23686857 Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
45 17050541 On the processing of proghrelin to ghrelin. Pubmed 7.107E-11 2.879E-9 2.328E-8 1.296E-7 3 4
46 23918928 Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. Pubmed 9.944E-10 3.941E-8 3.186E-7 1.813E-6 3 8
47 26416966 PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. Pubmed 1.491E-9 5.785E-8 4.677E-7 2.719E-6 3 9
48 15606899 Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. Pubmed 3.904E-9 1.453E-7 1.174E-6 7.117E-6 3 12
49 1354647 Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes. Pubmed 3.904E-9 1.453E-7 1.174E-6 7.117E-6 3 12
50 21518694 PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. Pubmed 9.932E-9 3.621E-7 2.928E-6 1.811E-5 3 16
Show 45 more annotations

9: Interaction [Display Chart] 11 input genes in category / 188 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PMCH PMCH interactions 1.008E-21 1.894E-19 1.102E-18 1.894E-19 7 11
2 int:IAPP IAPP interactions 9.808E-6 9.220E-4 5.363E-3 1.844E-3 2 8
3 int:REN REN interactions 2.309E-5 1.447E-3 8.415E-3 4.341E-3 2 12
4 int:BACE1 BACE1 interactions 1.616E-4 7.596E-3 4.418E-2 3.039E-2 2 31
5 int:ZP4 ZP4 interactions 1.242E-3 3.641E-2
2.118E-1
2.336E-1
 1 2
6 int:PRB4 PRB4 interactions 1.242E-3 3.641E-2
2.118E-1
2.336E-1
 1 2
7 int:CACNA1A CACNA1A interactions 1.851E-3 3.641E-2
2.118E-1
3.479E-1
 2 105
8 int:PCSK4 PCSK4 interactions 1.863E-3 3.641E-2
2.118E-1
3.503E-1
 1 3
9 int:SLAMF1 SLAMF1 interactions 2.065E-3 3.641E-2
2.118E-1
3.883E-1
 2 111
10 int:SORCS1 SORCS1 interactions 2.483E-3 3.641E-2
2.118E-1
4.669E-1
 1 4
11 int:TRH TRH interactions 2.483E-3 3.641E-2
2.118E-1
4.669E-1
 1 4
12 int:MNX1 MNX1 interactions 2.483E-3 3.641E-2
2.118E-1
4.669E-1
 1 4
13 int:PCSK2 PCSK2 interactions 3.103E-3 3.641E-2
2.118E-1
5.834E-1
 1 5
14 int:COL23A1 COL23A1 interactions 3.103E-3 3.641E-2
2.118E-1
5.834E-1
 1 5
15 int:PCSK6 PCSK6 interactions 3.723E-3 3.641E-2
2.118E-1
6.999E-1
 1 6
16 int:ABCC6 ABCC6 interactions 3.723E-3 3.641E-2
2.118E-1
6.999E-1
 1 6
17 int:CCK CCK interactions 4.342E-3 3.641E-2
2.118E-1
8.163E-1
 1 7
18 int:PCSK1 PCSK1 interactions 4.342E-3 3.641E-2
2.118E-1
8.163E-1
 1 7
19 int:TPCN1 TPCN1 interactions 4.342E-3 3.641E-2
2.118E-1
8.163E-1
 1 7
20 int:MFSD12 MFSD12 interactions 4.342E-3 3.641E-2
2.118E-1
8.163E-1
 1 7
21 int:SCG5 SCG5 interactions 4.342E-3 3.641E-2
2.118E-1
8.163E-1
 1 7
22 int:CNMD CNMD interactions 4.342E-3 3.641E-2
2.118E-1
8.163E-1
 1 7
23 int:PCSK7 PCSK7 interactions 4.961E-3 3.641E-2
2.118E-1
9.327E-1
 1 8
24 int:DSG3 DSG3 interactions 4.961E-3 3.641E-2
2.118E-1
9.327E-1
 1 8
25 int:GCG GCG interactions 5.580E-3 3.641E-2
2.118E-1
1.000E0
 1 9
26 int:PCSK1N PCSK1N interactions 5.580E-3 3.641E-2
2.118E-1
1.000E0
 1 9
27 int:AMH AMH interactions 5.580E-3 3.641E-2
2.118E-1
1.000E0
 1 9
28 int:PXYLP1 PXYLP1 interactions 5.580E-3 3.641E-2
2.118E-1
1.000E0
 1 9
29 int:ADAM19 ADAM19 interactions 6.198E-3 3.641E-2
2.118E-1
1.000E0
 1 10
30 int:SERPINB11 SERPINB11 interactions 6.198E-3 3.641E-2
2.118E-1
1.000E0
 1 10
31 int:SLC39A3 SLC39A3 interactions 6.198E-3 3.641E-2
2.118E-1
1.000E0
 1 10
32 int:NTS NTS interactions 6.198E-3 3.641E-2
2.118E-1
1.000E0
 1 10
33 int:GUSB GUSB interactions 7.433E-3 3.881E-2
2.257E-1
1.000E0
 1 12
34 int:RNASE13 RNASE13 interactions 7.433E-3 3.881E-2
2.257E-1
1.000E0
 1 12
35 int:ITM2C ITM2C interactions 7.433E-3 3.881E-2
2.257E-1
1.000E0
 1 12
36 int:SLC26A2 SLC26A2 interactions 8.050E-3 3.881E-2
2.257E-1
1.000E0
 1 13
37 int:TNFSF13 TNFSF13 interactions 8.050E-3 3.881E-2
2.257E-1
1.000E0
 1 13
38 int:ZP3 ZP3 interactions 8.050E-3 3.881E-2
2.257E-1
1.000E0
 1 13
39 int:CELA3A CELA3A interactions 8.050E-3 3.881E-2
2.257E-1
1.000E0
 1 13
40 int:TMEM39B TMEM39B interactions 8.667E-3 3.960E-2
2.303E-1
1.000E0
 1 14
41 int:DENND6A DENND6A interactions 9.284E-3 3.960E-2
2.303E-1
1.000E0
 1 15
42 int:NAGPA NAGPA interactions 9.284E-3 3.960E-2
2.303E-1
1.000E0
 1 15
43 int:GAST GAST interactions 9.284E-3 3.960E-2
2.303E-1
1.000E0
 1 15
44 int:RCN3 RCN3 interactions 9.284E-3 3.960E-2
2.303E-1
1.000E0
 1 15
45 int:PTPRM PTPRM interactions 9.900E-3 3.960E-2
2.303E-1
1.000E0
 1 16
46 int:PIGQ PIGQ interactions 9.900E-3 3.960E-2
2.303E-1
1.000E0
 1 16
47 int:PDGFA PDGFA interactions 9.900E-3 3.960E-2
2.303E-1
1.000E0
 1 16
48 int:LCE3C LCE3C interactions 1.052E-2 4.049E-2
2.355E-1
1.000E0
 1 17
49 int:SLC26A6 SLC26A6 interactions 1.175E-2 4.049E-2
2.355E-1
1.000E0
 1 19
50 int:DNAJC30 DNAJC30 interactions 1.175E-2 4.049E-2
2.355E-1
1.000E0
 1 19
Show 45 more annotations

10: Cytoband [Display Chart] 11 input genes in category / 11 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9q21.3 9q21.3 3.174E-4 3.490E-3 1.054E-2 3.491E-3 1 1
2 5q15-q21 5q15-q21 6.346E-4 3.490E-3 1.054E-2 6.981E-3 1 2
3 11q23-q24 11q23-q24 9.518E-4 3.490E-3 1.054E-2 1.047E-2 1 3
4 12q13-q14 12q13-q14 1.903E-3 5.233E-3 1.580E-2 2.093E-2 1 6
5 20p11.2 20p11.2 3.486E-3 7.669E-3 2.316E-2 3.835E-2 1 11
6 7q36 7q36 8.537E-3 1.565E-2 4.726E-2
9.390E-2
 1 27
7 4q32.3 4q32.3 1.074E-2 1.688E-2
5.096E-2
1.181E-1
 1 34
8 15q26.3 15q26.3 1.356E-2 1.865E-2
5.632E-2
1.492E-1
 1 43
9 1p32.3 1p32.3 1.919E-2 2.145E-2
6.479E-2
2.111E-1
 1 61
10 15q26.1 15q26.1 1.950E-2 2.145E-2
6.479E-2
2.145E-1
 1 62
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 124 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 973 Proprotein convertase subtilisin/kexin family genenames.org 1.362E-27 4.086E-27 7.491E-27 4.086E-27 8 9
2 1321 Carboxypeptidases genenames.org 1.149E-2 1.723E-2 3.158E-2 3.446E-2 1 21
3 518 HOXL subclass homeoboxes genenames.org 2.822E-2 2.822E-2
5.174E-2
8.467E-2
 1 52

13: Coexpression [Display Chart] 11 input genes in category / 917 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15149732-table3 Human Lung Turney04 4genes GeneSigDB 3.197E-10 2.931E-7 2.169E-6 2.931E-7 3 4
2 M5273 Genes up-regulated in comparison of type 2 myeloid (T2M) cells treated with IL25 [GeneID=64806] versus macrophages treated with IL25 [GeneID=64806]. MSigDB C7: Immunologic Signatures (v6.0) 9.976E-5 3.638E-2
2.692E-1
9.148E-2
 3 200
3 M1760 Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.508E-4 3.638E-2
2.692E-1
1.383E-1
 2 39
4 M5957 Genes specifically up-regulated in pancreatic beta cells. MSigDB H: Hallmark Gene Sets (v6.0) 1.587E-4 3.638E-2
2.692E-1
1.455E-1
 2 40
5 14755241-Table2a Human Skin VanGele04 46genes GeneSigDB 2.103E-4 3.856E-2
2.853E-1
1.928E-1
 2 46

14: Coexpression Atlas [Display Chart] 11 input genes in category / 761 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Top 40 GSE76381_ESMoleculeCountsPMLog2 3.365E-5 2.561E-2
1.847E-1
 2.561E-2 3 131
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/type B pancreatic cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/type B pancreatic cell Tabula Muris Consortium 1.017E-4 3.871E-2
2.792E-1
7.742E-2
 3 190
3 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Overall Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 1.607E-4 4.076E-2
2.940E-1
1.223E-1
 2 38
4 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup9/Adora2a/Adora2a,Pde1c BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup9/Adora2a/Adora2a,Pde1c BrainMap 3.629E-4 4.860E-2
3.506E-1
2.762E-1
 2 57
5 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Slc24a2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Slc24a2 Top 200 Genes BrainMap 3.757E-4 4.860E-2
3.506E-1
2.859E-1
 3 296
6 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb3 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eNb Subtype eNb3 Top 40 Genes GSE76381_ESMoleculeCountsPMLog2 4.434E-4 4.860E-2
3.506E-1
3.374E-1
 2 63
7 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Subtype iNb1 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Subtype iNb1 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 5.317E-4 4.860E-2
3.506E-1
4.046E-1
 2 69
8 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 5.317E-4 4.860E-2
3.506E-1
4.046E-1
 2 69
9 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Subtype iNb2 Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iNb Subtype iNb2 Top 40 Genes GSE76381_iPSMoleculeCountsPMLog2 5.950E-4 4.860E-2
3.506E-1
4.528E-1
 2 73
10 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 6.387E-4 4.860E-2
3.506E-1
4.860E-1
 3 355
Show 5 more annotations

15: Computational [Display Chart] 10 input genes in category / 47 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 11 input genes in category / 438 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ACCAAAG,MIR-9:MSigDB ACCAAAG,MIR-9:MSigDB MSigDB 4.371E-5 7.046E-3 4.693E-2 1.914E-2 3 471
2 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 4.826E-5 7.046E-3 4.693E-2 2.114E-2 3 487
3 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 4.826E-5 7.046E-3 4.693E-2 2.114E-2 3 487
4 hsa-miR-4518:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.143E-5 7.845E-3
5.225E-2
 4.005E-2 2 94
5 hsa-miR-1266-5p:Functional MTI Functional MTI miRTarbase 9.339E-5 7.845E-3
5.225E-2
 4.090E-2 2 95
6 hsa-miR-211-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.466E-4 7.845E-3
5.225E-2
6.419E-2
 2 119
7 hsa-miR-1972:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.591E-4 7.845E-3
5.225E-2
6.969E-2
 2 124
8 hsa-miR-4328:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.695E-4 7.845E-3
5.225E-2
7.426E-2
 2 128
9 AGGGCAG,MIR-18A:MSigDB AGGGCAG,MIR-18A:MSigDB MSigDB 1.722E-4 7.845E-3
5.225E-2
7.542E-2
 2 129
10 hsa-miR-8052:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.970E-4 7.845E-3
5.225E-2
8.629E-2
 2 138
11 hsa-miR-3199:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.970E-4 7.845E-3
5.225E-2
8.629E-2
 2 138
12 hsa-miR-3664-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.199E-4 9.411E-3
6.268E-2
1.401E-1
 2 176
13 hsa-miR-4505:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.383E-4 9.411E-3
6.268E-2
1.482E-1
 2 181
14 hsa-miR-5787:Functional MTI Functional MTI miRTarbase 3.420E-4 9.411E-3
6.268E-2
1.498E-1
 2 182
15 hsa-miR-6733-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.044E-4 9.411E-3
6.268E-2
1.771E-1
 2 198
16 hsa-miR-3153:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.044E-4 9.411E-3
6.268E-2
1.771E-1
 2 198
17 hsa-miR-220c:PITA hsa-miR-220c:PITA TOP PITA 4.292E-4 9.411E-3
6.268E-2
1.880E-1
 2 204
18 hsa-miR-6739-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.292E-4 9.411E-3
6.268E-2
1.880E-1
 2 204
19 hsa-miR-500b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.376E-4 9.411E-3
6.268E-2
1.917E-1
 2 206
20 hsa-miR-99a:mirSVR lowEffct hsa-miR-99a:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 4.633E-4 9.411E-3
6.268E-2
2.029E-1
 2 212
21 hsa-miR-4270:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.852E-4 9.411E-3
6.268E-2
2.125E-1
 2 217
22 hsa-miR-6754-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.897E-4 9.411E-3
6.268E-2
2.145E-1
 2 218
23 hsa-miR-4441:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.942E-4 9.411E-3
6.268E-2
2.164E-1
 2 219
24 hsa-miR-6856-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.581E-4 1.201E-2
7.999E-2
2.882E-1
 2 253
25 hsa-miR-6758-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.894E-4 1.206E-2
8.034E-2
3.019E-1
 2 259
26 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 7.160E-4 1.206E-2
8.034E-2
3.136E-1
 2 264
27 hsa-let-7i*:mirSVR lowEffct hsa-let-7i*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.624E-4 1.399E-2
9.318E-2
3.777E-1
 2 290
28 hsa-miR-107:Functional MTI Functional MTI miRTarbase 9.222E-4 1.443E-2
9.609E-2
4.039E-1
 2 300
29 hsa-miR-8055:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.035E-3 1.480E-2
9.860E-2
4.533E-1
 2 318
30 hsa-miR-125b:PITA hsa-miR-125b:PITA TOP PITA 1.048E-3 1.480E-2
9.860E-2
4.589E-1
 2 320
31 hsa-miR-125a-5p:PITA hsa-miR-125a-5p:PITA TOP PITA 1.048E-3 1.480E-2
9.860E-2
4.589E-1
 2 320
32 hsa-miR-765:Functional MTI Functional MTI miRTarbase 1.251E-3 1.688E-2
1.124E-1
5.478E-1
 2 350
33 hsa-miR-572:mirSVR lowEffct hsa-miR-572:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.272E-3 1.688E-2
1.124E-1
5.571E-1
 2 353
34 hsa-miR-4695-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.396E-3 1.798E-2
1.197E-1
6.113E-1
 2 370
35 hsa-miR-4281:mirSVR lowEffct hsa-miR-4281:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.708E-3 2.117E-2
1.410E-1
7.483E-1
 2 410
36 hsa-miR-3612:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.825E-3 2.117E-2
1.410E-1
7.994E-1
 2 424
37 hsa-miR-650:Functional MTI Functional MTI miRTarbase 1.851E-3 2.117E-2
1.410E-1
8.106E-1
 2 427
38 hsa-miR-2114*:mirSVR highEffct hsa-miR-2114*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.868E-3 2.117E-2
1.410E-1
8.180E-1
 2 429
39 hsa-miR-410-3p:TargetScan hsa-miR-410-3p TargetScan 1.885E-3 2.117E-2
1.410E-1
8.256E-1
 2 431
40 hsa-miR-887-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.586E-3 2.831E-2
1.886E-1
1.000E0
 1 17
41 hsa-miR-4738-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.407E-3 4.708E-2
3.136E-1
1.000E0
 1 29
42 hsa-miR-1277:PITA hsa-miR-1277:PITA TOP PITA 4.559E-3 4.754E-2
3.167E-1
1.000E0
 1 30
Show 37 more annotations

17: Drug [Display Chart] 11 input genes in category / 3734 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000327967 AC1L71LQ Stitch 4.791E-19 1.789E-15 1.575E-14 1.789E-15 9 139
2 CID000327966 AC1L71LN Stitch 1.268E-16 2.366E-13 2.083E-12 4.733E-13 8 128
3 CID000151956 Arginylarginine Stitch 9.165E-16 9.580E-13 8.433E-12 3.422E-12 8 163
4 CID000005936 diisopropylfluorophosphate Stitch 1.026E-15 9.580E-13 8.433E-12 3.832E-12 9 321
5 CID000447561 AC1L9KZ2 Stitch 2.854E-14 2.131E-11 1.876E-10 1.066E-10 6 48
6 ctd:C104705 dopamine quinone CTD 1.455E-13 9.055E-11 7.970E-10 5.433E-10 4 5
7 CID000001305 AC1L1B6K Stitch 1.264E-12 6.745E-10 5.937E-9 4.721E-9 5 30
8 CID000126332 glicentin Stitch 1.685E-11 7.864E-9 6.923E-8 6.291E-8 5 49
9 CID000121906 TRH-Gly Stitch 3.962E-11 1.644E-8 1.447E-7 1.479E-7 4 15
10 CID004369084 PNU-107859 Stitch 8.023E-11 2.996E-8 2.637E-7 2.996E-7 6 174
11 CID000398798 TC-3 Stitch 9.887E-11 3.356E-8 2.954E-7 3.692E-7 5 69
12 CID000070905 B-13 Stitch 1.124E-10 3.497E-8 3.079E-7 4.197E-7 4 19
13 CID000023305 2-methylindoline Stitch 1.405E-10 4.035E-8 3.551E-7 5.245E-7 4 20
14 CID005311003 alpha-neoendorphin Stitch 1.183E-9 3.154E-7 2.776E-6 4.416E-6 4 33
15 CID000150311 ezetimibe Stitch 4.618E-9 1.084E-6 9.546E-6 1.724E-5 5 147
16 CID000195414 Cck-gly Stitch 4.647E-9 1.084E-6 9.546E-6 1.735E-5 3 8
17 CID000092249 7-amino-4-methylcoumarin Stitch 1.307E-8 2.871E-6 2.527E-5 4.880E-5 4 59
18 DB00030 Insulin recombinant Drug Bank 1.824E-8 3.783E-6 3.330E-5 6.810E-5 3 12
19 DB00071 Insulin, porcine Drug Bank 2.370E-8 4.623E-6 4.070E-5 8.850E-5 3 13
20 CID000003922 LG100268 Stitch 2.476E-8 4.623E-6 4.070E-5 9.247E-5 4 69
21 CID000343585 NSC383468 Stitch 2.626E-8 4.669E-6 4.110E-5 9.805E-5 4 70
22 CID000171155 A-17 Stitch 3.769E-8 6.396E-6 5.631E-5 1.407E-4 3 15
23 CID000036939 AC1L1XQM Stitch 5.629E-8 9.139E-6 8.045E-5 2.102E-4 3 17
24 CID004459028 AC1NAX4S Stitch 2.109E-7 3.207E-5 2.823E-4 7.873E-4 2 2
25 CID000037419 butamifos Stitch 2.147E-7 3.207E-5 2.823E-4 8.018E-4 3 26
26 ctd:D012110 Reserpine CTD 2.247E-7 3.227E-5 2.840E-4 8.390E-4 4 119
27 CID000111104 AC1ODVCS Stitch 3.350E-7 4.632E-5 4.078E-4 1.251E-3 3 30
28 CID000008264 dimefox Stitch 5.393E-7 6.712E-5 5.908E-4 2.014E-3 3 35
29 CID000003464 guanidinoethylmercaptosuccinic acid Stitch 5.393E-7 6.712E-5 5.908E-4 2.014E-3 3 35
30 CID000122313 Pyr-his-gly Stitch 5.393E-7 6.712E-5 5.908E-4 2.014E-3 3 35
31 CID000054454 simvastatin Stitch 6.006E-7 7.234E-5 6.368E-4 2.243E-3 5 390
32 CID000485268 GPGR Stitch 6.945E-7 8.104E-5 7.134E-4 2.593E-3 3 38
33 ctd:D009638 Norepinephrine CTD 9.833E-7 1.113E-4 9.794E-4 3.672E-3 4 172
34 CID000000899 N-acetylhexosamine Stitch 1.538E-6 1.689E-4 1.487E-3 5.743E-3 5 472
35 CID000448533 Ab-Z Stitch 2.271E-6 2.391E-4 2.104E-3 8.481E-3 3 56
36 CID000130105 CV-1 Stitch 2.305E-6 2.391E-4 2.104E-3 8.607E-3 4 213
37 CID005044311 N-succinyl-Ala-Ala-Pro-Leu-p-nitroanilide Stitch 3.159E-6 3.105E-4 2.733E-3 1.180E-2 2 6
38 CID000093175 D2-197 Stitch 3.159E-6 3.105E-4 2.733E-3 1.180E-2 2 6
39 CID006432229 CHCl Stitch 3.571E-6 3.419E-4 3.009E-3 1.333E-2 3 65
40 CID006328166 AC1O3H1D Stitch 3.914E-6 3.654E-4 3.216E-3 1.461E-2 3 67
41 CID000023912 dysprosium Stitch 5.287E-6 4.730E-4 4.164E-3 1.974E-2 3 74
42 CID000004784 phenylmethylsulfonyl fluoride Stitch 5.321E-6 4.730E-4 4.164E-3 1.987E-2 4 263
43 CID006102682 F-dd Stitch 6.945E-6 6.031E-4 5.309E-3 2.593E-2 3 81
44 CID000006406 acetone cyanohydrin Stitch 7.577E-6 6.430E-4 5.660E-3 2.829E-2 2 9
45 CID000003498 AC1L1G2K Stitch 7.750E-6 6.431E-4 5.661E-3 2.894E-2 3 84
46 CID006450978 Dasm Stitch 9.468E-6 7.686E-4 6.766E-3 3.536E-2 2 10
47 CID000031247 vinyl butyrate Stitch 1.157E-5 8.816E-4 7.761E-3 4.320E-2 2 11
48 CID000012961 mercaptoacetamide Stitch 1.157E-5 8.816E-4 7.761E-3 4.320E-2 2 11
49 CID000297862 Z-Gly-Gly-Leu Stitch 1.157E-5 8.816E-4 7.761E-3 4.320E-2 2 11
50 CID000160143 AC1L4N48 Stitch 1.388E-5 1.016E-3 8.945E-3
5.183E-2
 2 12
Show 45 more annotations

18: Disease [Display Chart] 11 input genes in category / 255 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1531773 Currarino triad DisGeNET Curated 2.512E-6 6.405E-4 3.920E-3 6.405E-4 2 4
2 C0300948 Caudal Regression Syndrome DisGeNET Curated 8.781E-6 1.120E-3 6.852E-3 2.239E-3 2 7
3 C0003466 Anus, Imperforate DisGeNET Curated 4.454E-4 7.868E-3 4.816E-2
1.136E-1
 2 47
4 C0221406 Pituitary-dependent Cushing's disease DisGeNET Curated 4.645E-4 7.868E-3 4.816E-2
1.185E-1
 2 48
5 C0497406 Overweight DisGeNET Curated 4.731E-4 7.868E-3 4.816E-2
1.206E-1
 3 238
6 cv:C1863551 Hypercholesterolemia, autosomal dominant, 3 Clinical Variations 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
7 C0205929 Anal Fistula DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
8 C0236124 Gastrointestinal obstruction DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
9 OMIN:600955 PROPROTEIN CONVERTASE 1/3 DEFICIENCY OMIM 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
10 cv:C1531773 Currarino triad Clinical Variations 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
11 OMIN:603776 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, 3; HCHOLA3 OMIM 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
12 C1261470 Congenital meningocele DisGeNET BeFree 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
13 cv:C1833053 Proprotein convertase 1/3 deficiency Clinical Variations 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
14 OMIN:612362 BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 12; BMIQ12 OMIM 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
15 C1867776 Anterior sacral meningocele DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
16 cv:C2676498 Body mass index quantitative trait locus 12 Clinical Variations 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
17 C2676498 BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 12 (disorder) DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
18 C1863551 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, 3 DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
19 C1833053 Proprotein Convertase 1 3 Deficiency DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
20 C0009730 Spinal meningocele DisGeNET BeFree 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
21 C0851302 Hypoglycemic shock DisGeNET BeFree 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
22 C1867782 Presacral teratoma DisGeNET Curated 6.788E-4 7.868E-3 4.816E-2
1.731E-1
 1 1
23 C0162835 Hypopigmentation disorder DisGeNET Curated 1.043E-3 1.154E-2
7.061E-2
2.660E-1
 2 72
24 C0431943 Lower Extremity Deformities, Congenital DisGeNET Curated 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
25 C4024660 Aplasia/Hypoplasia of the sacrum DisGeNET Curated 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
26 C1838568 Sacral defect and anterior sacral meningocele DisGeNET Curated 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
27 C0220708 VATER Association DisGeNET Curated 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
28 C0342283 Hyperproinsulinemia DisGeNET Curated 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
29 C0751007 Intracranial Atherosclerosis DisGeNET BeFree 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
30 C0269190 Squamous metaplasia of cervix DisGeNET BeFree 1.357E-3 1.154E-2
7.061E-2
3.461E-1
 1 2
31 C0577631 Carotid Atherosclerosis DisGeNET BeFree 1.807E-3 1.442E-2
8.823E-2
4.608E-1
 2 95
32 C0271623 Hypogonadotropic hypogonadism DisGeNET Curated 2.000E-3 1.442E-2
8.823E-2
5.099E-1
 2 100
33 C1854107 Hyperaldosteronism, Familial, Type II DisGeNET Curated 2.035E-3 1.442E-2
8.823E-2
5.190E-1
 1 3
34 C0266411 Septate vagina DisGeNET Curated 2.035E-3 1.442E-2
8.823E-2
5.190E-1
 1 3
35 C4024583 Fat tissue increased DisGeNET Curated 2.035E-3 1.442E-2
8.823E-2
5.190E-1
 1 3
36 C1859846 Truncal obesity apparent in childhood DisGeNET Curated 2.035E-3 1.442E-2
8.823E-2
5.190E-1
 1 3
37 C0025299 Meningocele DisGeNET Curated 2.713E-3 1.647E-2
1.008E-1
6.917E-1
 1 4
38 C0031019 Perianal abscess DisGeNET Curated 2.713E-3 1.647E-2
1.008E-1
6.917E-1
 1 4
39 C3273035 Poorly Differentiated Hepatocellular Carcinoma DisGeNET BeFree 2.713E-3 1.647E-2
1.008E-1
6.917E-1
 1 4
40 C0271710 Reactive hypoglycemia DisGeNET Curated 2.713E-3 1.647E-2
1.008E-1
6.917E-1
 1 4
41 C0334439 Malignant desmoplastic melanoma DisGeNET BeFree 2.713E-3 1.647E-2
1.008E-1
6.917E-1
 1 4
42 C0342881 Familial hypercholesterolemia - homozygous DisGeNET Curated 2.713E-3 1.647E-2
1.008E-1
6.917E-1
 1 4
43 C0034895 Rectovaginal Fistula DisGeNET Curated 3.390E-3 1.965E-2
1.202E-1
8.644E-1
 1 5
44 C0041364 Tumor Lysis Syndrome DisGeNET Curated 3.390E-3 1.965E-2
1.202E-1
8.644E-1
 1 5
45 C0344490 Sacral agenesis DisGeNET Curated 4.067E-3 2.254E-2
1.380E-1
1.000E0
 1 6
46 C0239803 Red hair DisGeNET Curated 4.067E-3 2.254E-2
1.380E-1
1.000E0
 1 6
47 C1304456 Congo hemorrhagic fever DisGeNET BeFree 4.743E-3 2.419E-2
1.480E-1
1.000E0
 1 7
48 C0005697 Neurogenic Urinary Bladder DisGeNET Curated 4.743E-3 2.419E-2
1.480E-1
1.000E0
 1 7
49 C0080218 Tethered Cord Syndrome DisGeNET Curated 4.743E-3 2.419E-2
1.480E-1
1.000E0
 1 7
50 C0948387 Secondary Adrenal Insufficiency DisGeNET Curated 4.743E-3 2.419E-2
1.480E-1
1.000E0
 1 7
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