Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc265_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019208 phosphatase regulator activity 1.242E-11 3.106E-10 1.185E-9 3.106E-10 5 88
2 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3.044E-9 3.155E-8 1.204E-7 7.611E-8 3 11
3 GO:0019888 protein phosphatase regulator activity 3.786E-9 3.155E-8 1.204E-7 9.466E-8 4 76
4 GO:0004864 protein phosphatase inhibitor activity 1.551E-7 9.697E-7 3.700E-6 3.879E-6 3 38
5 GO:0019212 phosphatase inhibitor activity 1.960E-7 9.799E-7 3.739E-6 4.900E-6 3 41
6 GO:0004857 enzyme inhibitor activity 1.768E-4 6.943E-4 2.650E-3 4.421E-3 3 393
7 GO:0004722 protein serine/threonine phosphatase activity 1.944E-4 6.943E-4 2.650E-3 4.860E-3 2 68
8 GO:0031751 D4 dopamine receptor binding 6.430E-4 2.009E-3 7.667E-3 1.607E-2 1 2
9 GO:0031752 D5 dopamine receptor binding 9.643E-4 2.679E-3 1.022E-2 2.411E-2 1 3
10 GO:0031750 D3 dopamine receptor binding 1.286E-3 3.214E-3 1.226E-2 3.214E-2 1 4
11 GO:0004721 phosphoprotein phosphatase activity 1.537E-3 3.494E-3 1.333E-2 3.843E-2 2 192
12 GO:0031749 D2 dopamine receptor binding 1.928E-3 4.016E-3 1.533E-2 4.820E-2 1 6
13 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2.891E-3 5.559E-3 2.121E-2
7.227E-2
 1 9
14 GO:0016791 phosphatase activity 3.279E-3 5.856E-3 2.235E-2
8.198E-2
 2 282
15 GO:0031748 D1 dopamine receptor binding 3.532E-3 5.887E-3 2.246E-2
8.830E-2
 1 11
16 GO:0050780 dopamine receptor binding 7.054E-3 1.094E-2 4.175E-2
1.763E-1
 1 22
17 GO:0042578 phosphoric ester hydrolase activity 7.439E-3 1.094E-2 4.175E-2
1.860E-1
 2 429
18 GO:0030291 protein serine/threonine kinase inhibitor activity 9.608E-3 1.334E-2
5.092E-2
2.402E-1
 1 30
19 GO:0004860 protein kinase inhibitor activity 2.828E-2 3.614E-2
1.379E-1
7.070E-1
 1 89
20 GO:0019210 kinase inhibitor activity 2.891E-2 3.614E-2
1.379E-1
7.227E-1
 1 91
Show 15 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 49 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006470 protein dephosphorylation 1.199E-4 3.353E-3 1.502E-2 5.875E-3 3 344
2 GO:0016311 dephosphorylation 2.569E-4 3.353E-3 1.502E-2 1.259E-2 3 445
3 GO:0005977 glycogen metabolic process 3.346E-4 3.353E-3 1.502E-2 1.639E-2 2 89
4 GO:0044042 glucan metabolic process 3.421E-4 3.353E-3 1.502E-2 1.676E-2 2 90
5 GO:0006073 cellular glucan metabolic process 3.421E-4 3.353E-3 1.502E-2 1.676E-2 2 90
6 GO:0006112 energy reserve metabolic process 4.479E-4 3.383E-3 1.515E-2 2.195E-2 2 103
7 GO:0044264 cellular polysaccharide metabolic process 4.832E-4 3.383E-3 1.515E-2 2.368E-2 2 107
8 GO:0005976 polysaccharide metabolic process 6.174E-4 3.782E-3 1.694E-2 3.025E-2 2 121
9 GO:0035304 regulation of protein dephosphorylation 1.089E-3 5.738E-3 2.570E-2
5.336E-2
 2 161
10 GO:0035303 regulation of dephosphorylation 1.171E-3 5.738E-3 2.570E-2
5.738E-2
 2 167
11 GO:0007621 negative regulation of female receptivity 1.288E-3 5.738E-3 2.570E-2
6.312E-2
 1 4
12 GO:0045924 regulation of female receptivity 2.897E-3 1.183E-2
5.298E-2
1.419E-1
 1 9
13 GO:0015980 energy derivation by oxidation of organic compounds 3.385E-3 1.239E-2
5.549E-2
1.658E-1
 2 286
14 GO:0060180 female mating behavior 3.539E-3 1.239E-2
5.549E-2
1.734E-1
 1 11
15 GO:0044262 cellular carbohydrate metabolic process 4.218E-3 1.378E-2
6.172E-2
2.067E-1
 2 320
16 GO:0006091 generation of precursor metabolites and energy 6.299E-3 1.929E-2
8.641E-2
3.086E-1
 2 393
17 GO:0044705 multi-organism reproductive behavior 9.308E-3 2.534E-2
1.135E-1
4.561E-1
 1 29
18 GO:0007617 mating behavior 9.308E-3 2.534E-2
1.135E-1
4.561E-1
 1 29
19 GO:0001975 response to amphetamine 1.091E-2 2.813E-2
1.260E-1
5.344E-1
 1 34
20 GO:0019098 reproductive behavior 1.282E-2 3.141E-2
1.407E-1
6.282E-1
 1 40
21 GO:0014075 response to amine 1.664E-2 3.527E-2
1.580E-1
8.153E-1
 1 52
22 GO:0007618 mating 1.696E-2 3.527E-2
1.580E-1
8.309E-1
 1 53
23 GO:0005978 glycogen biosynthetic process 1.727E-2 3.527E-2
1.580E-1
8.465E-1
 1 54
24 GO:0009250 glucan biosynthetic process 1.727E-2 3.527E-2
1.580E-1
8.465E-1
 1 54
25 GO:0008542 visual learning 1.981E-2 3.883E-2
1.739E-1
9.708E-1
 1 62
26 GO:0007632 visual behavior 2.140E-2 3.998E-2
1.791E-1
1.000E0
 1 67
27 GO:0033692 cellular polysaccharide biosynthetic process 2.203E-2 3.998E-2
1.791E-1
1.000E0
 1 69
28 GO:0000271 polysaccharide biosynthetic process 2.519E-2 4.362E-2
1.954E-1
1.000E0
 1 79
29 GO:0034637 cellular carbohydrate biosynthetic process 2.582E-2 4.362E-2
1.954E-1
1.000E0
 1 81
30 GO:0051705 multi-organism behavior 2.865E-2 4.628E-2
2.073E-1
1.000E0
 1 90
31 GO:0008306 associative learning 2.928E-2 4.628E-2
2.073E-1
1.000E0
 1 92
Show 26 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 9 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042587 glycogen granule 2.516E-3 2.264E-2
6.406E-2
 2.264E-2 1 8

4: Human Phenotype [Display Chart] 1 input genes in category / 2 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000855 Insulin resistance 3.378E-2 3.909E-2
5.864E-2
6.756E-2
 1 159
2 HP:0005978 Type II diabetes mellitus 3.909E-2 3.909E-2
5.864E-2
7.818E-2
 1 184

5: Mouse Phenotype [Display Chart] 4 input genes in category / 72 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020159 abnormal behavioral response to morphine 1.017E-5 7.322E-4 3.559E-3 7.322E-4 2 14
2 MP:0030022 decreased muscle cell glucose uptake 3.626E-5 1.305E-3 6.346E-3 2.611E-3 2 26
3 MP:0009711 abnormal conditioned place preference behavior 7.020E-5 1.685E-3 8.190E-3 5.055E-3 2 36
4 MP:0009749 enhanced behavioral response to addictive substance 1.418E-4 2.552E-3 1.241E-2 1.021E-2 2 51
5 MP:0004130 abnormal muscle cell glucose uptake 2.995E-4 3.392E-3 1.649E-2 2.156E-2 2 74
6 MP:0005439 decreased glycogen level 3.243E-4 3.392E-3 1.649E-2 2.335E-2 2 77
7 MP:0009746 enhanced behavioral response to xenobiotic 3.414E-4 3.392E-3 1.649E-2 2.458E-2 2 79
8 MP:0003925 abnormal cellular glucose import 3.769E-4 3.392E-3 1.649E-2 2.714E-2 2 83
9 MP:0009748 abnormal behavioral response to addictive substance 6.030E-4 4.824E-3 2.345E-2 4.342E-2 2 105
10 MP:0005437 abnormal glycogen level 1.070E-3 7.583E-3 3.686E-2
7.702E-2
 2 140
11 MP:0014063 Lafora bodies 1.159E-3 7.583E-3 3.686E-2
8.341E-2
 1 3
12 MP:0005438 abnormal glycogen homeostasis 1.326E-3 7.959E-3 3.869E-2
9.551E-2
 2 156
13 MP:0009753 enhanced behavioral response to morphine 1.544E-3 8.554E-3 4.158E-2
1.112E-1
 1 4
14 MP:0005331 insulin resistance 1.900E-3 9.266E-3 4.504E-2
1.368E-1
 2 187
15 MP:0002629 hyperactivity elicited by ethanol administration 1.930E-3 9.266E-3 4.504E-2
1.390E-1
 1 5
16 MP:0001981 increased chemically-elicited antinociception 2.702E-3 1.216E-2
5.910E-2
1.945E-1
 1 7
17 MP:0005584 abnormal enzyme/coenzyme activity 3.784E-3 1.603E-2
7.790E-2
2.724E-1
 2 265
18 MP:0009757 impaired behavioral response to morphine 4.243E-3 1.697E-2
8.250E-2
3.055E-1
 1 11
19 MP:0020411 increased abdominal adipose tissue amount 4.628E-3 1.754E-2
8.525E-2
3.332E-1
 1 12
20 MP:0009745 abnormal behavioral response to xenobiotic 4.956E-3 1.784E-2
8.673E-2
3.569E-1
 2 304
21 MP:0002062 abnormal associative learning 5.448E-3 1.868E-2
9.079E-2
3.922E-1
 2 319
22 MP:0009751 enhanced behavioral response to alcohol 6.167E-3 2.018E-2
9.811E-2
4.440E-1
 1 16
23 MP:0005293 impaired glucose tolerance 6.903E-3 2.081E-2
1.011E-1
4.970E-1
 2 360
24 MP:0009758 impaired behavioral response to cocaine 6.936E-3 2.081E-2
1.011E-1
4.994E-1
 1 18
25 MP:0020157 abnormal behavioral response to alcohol 8.472E-3 2.440E-2
1.186E-1
6.100E-1
 1 22
26 MP:0009754 enhanced behavioral response to cocaine 9.624E-3 2.665E-2
1.295E-1
6.929E-1
 1 25
27 MP:0009712 impaired conditioned place preference behavior 1.077E-2 2.873E-2
1.397E-1
7.757E-1
 1 28
28 MP:0001980 abnormal chemically-elicited antinociception 1.192E-2 2.953E-2
1.436E-1
8.585E-1
 1 31
29 MP:0001425 abnormal alcohol consumption 1.231E-2 2.953E-2
1.436E-1
8.860E-1
 1 32
30 MP:0030021 increased muscle cell glucose uptake 1.231E-2 2.953E-2
1.436E-1
8.860E-1
 1 32
31 MP:0020158 abnormal behavioral response to cocaine 1.422E-2 3.302E-2
1.605E-1
1.000E0
 1 37
32 MP:0008911 induced hyperactivity 1.536E-2 3.457E-2
1.680E-1
1.000E0
 1 40
33 MP:0009750 impaired behavioral response to addictive substance 1.956E-2 4.267E-2
2.074E-1
1.000E0
 1 51
Show 28 more annotations

6: Domain [Display Chart] 6 input genes in category / 22 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1.10.150.220 - Gene3D 5.127E-7 3.760E-6 1.388E-5 1.128E-5 2 4
2 IPR008025 PP1 inhibitor InterPro 5.127E-7 3.760E-6 1.388E-5 1.128E-5 2 4
3 PF05361 PP1 inhibitor Pfam 5.127E-7 3.760E-6 1.388E-5 1.128E-5 2 4
4 IPR005036 CBM21 dom InterPro 1.794E-6 6.577E-6 2.427E-5 3.946E-5 2 7
5 PS51159 CBM21 PROSITE 1.794E-6 6.577E-6 2.427E-5 3.946E-5 2 7
6 PF03370 CBM 21 Pfam 1.794E-6 6.577E-6 2.427E-5 3.946E-5 2 7
7 IPR015670 DARPP-32 InterPro 3.203E-4 8.807E-4 3.251E-3 7.046E-3 1 1
8 IPR030683 PP1 3C InterPro 3.203E-4 8.807E-4 3.251E-3 7.046E-3 1 1
9 IPR017434 Pase-1 reg-su 3B/C/D met InterPro 9.605E-4 1.509E-3 5.571E-3 2.113E-2 1 3
10 PF15898 PRKG1 interact Pfam 9.605E-4 1.509E-3 5.571E-3 2.113E-2 1 3
11 IPR008466 PPP1R1A/B/C InterPro 9.605E-4 1.509E-3 5.571E-3 2.113E-2 1 3
12 IPR031775 PRKG1 interact InterPro 9.605E-4 1.509E-3 5.571E-3 2.113E-2 1 3
13 IPR017401 MYPT1/MYPT2 chordates InterPro 9.605E-4 1.509E-3 5.571E-3 2.113E-2 1 3
14 PF05395 DARPP-32 Pfam 9.605E-4 1.509E-3 5.571E-3 2.113E-2 1 3
Show 9 more annotations

7: Pathway [Display Chart] 4 input genes in category / 42 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000532 glycogen biosynthetic Pathway Ontology 1.183E-5 4.477E-4 1.937E-3 4.967E-4 2 18
2 PW:0000534 glycogen degradation Pathway Ontology 2.132E-5 4.477E-4 1.937E-3 8.954E-4 2 24
3 1272486 Insulin resistance BioSystems: KEGG 4.342E-4 6.078E-3 2.630E-2 1.823E-2 2 107
4 83090 Insulin signaling pathway BioSystems: KEGG 7.213E-4 7.573E-3 3.277E-2 3.029E-2 2 138
5 1268953 Glycogen storage diseases BioSystems: REACTOME 3.209E-3 1.926E-2
8.332E-2
1.348E-1
 1 10
6 1268954 Myoclonic epilepsy of Lafora BioSystems: REACTOME 3.209E-3 1.926E-2
8.332E-2
1.348E-1
 1 10
7 1268940 Diseases of carbohydrate metabolism BioSystems: REACTOME 3.209E-3 1.926E-2
8.332E-2
1.348E-1
 1 10
8 1269962 Glycogen synthesis BioSystems: REACTOME 4.811E-3 2.290E-2
9.906E-2
2.021E-1
 1 15
9 M16626 Regulation of ck1/cdk5 by type 1 glutamate receptors MSigDB C2 BIOCARTA (v6.0) 5.451E-3 2.290E-2
9.906E-2
2.290E-1
 1 17
10 1269510 RHO GTPases Activate ROCKs BioSystems: REACTOME 5.451E-3 2.290E-2
9.906E-2
2.290E-1
 1 17
11 1269511 RHO GTPases activate PAKs BioSystems: REACTOME 7.370E-3 2.381E-2
1.030E-1
3.095E-1
 1 23
12 M9152 CCR3 signaling in Eosinophils MSigDB C2 BIOCARTA (v6.0) 7.370E-3 2.381E-2
1.030E-1
3.095E-1
 1 23
13 M8601 Rac 1 cell motility signaling pathway MSigDB C2 BIOCARTA (v6.0) 7.370E-3 2.381E-2
1.030E-1
3.095E-1
 1 23
14 1269591 DARPP-32 events BioSystems: REACTOME 8.648E-3 2.390E-2
1.034E-1
3.632E-1
 1 27
15 P06587 Nicotine pharmacodynamics pathway PantherDB 9.286E-3 2.390E-2
1.034E-1
3.900E-1
 1 29
16 137981 Insulin-mediated glucose transport BioSystems: Pathway Interaction Database 9.286E-3 2.390E-2
1.034E-1
3.900E-1
 1 29
17 M7014 PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase MSigDB C2 BIOCARTA (v6.0) 9.924E-3 2.390E-2
1.034E-1
4.168E-1
 1 31
18 M1001 Rho cell motility signaling pathway MSigDB C2 BIOCARTA (v6.0) 1.024E-2 2.390E-2
1.034E-1
4.302E-1
 1 32
19 SMP00391 Insulin Signalling SMPDB 1.152E-2 2.431E-2
1.052E-1
4.837E-1
 1 36
20 M3494 Thrombin signaling and protease-activated receptors MSigDB C2 BIOCARTA (v6.0) 1.184E-2 2.431E-2
1.052E-1
4.971E-1
 1 37
21 M3342 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.215E-2 2.431E-2
1.052E-1
5.105E-1
 1 38
22 1268939 Diseases of metabolism BioSystems: REACTOME 1.438E-2 2.746E-2
1.188E-1
6.040E-1
 1 45
23 546258 Cocaine addiction BioSystems: KEGG 1.565E-2 2.858E-2
1.237E-1
6.574E-1
 1 49
24 P05912 Dopamine receptor mediated signaling pathway PantherDB 1.660E-2 2.906E-2
1.257E-1
6.974E-1
 1 52
25 547607 Amphetamine addiction BioSystems: KEGG 2.167E-2 3.641E-2
1.575E-1
9.102E-1
 1 68
26 1269959 Glucose metabolism BioSystems: REACTOME 2.577E-2 4.164E-2
1.801E-1
1.000E0
 1 81
27 1269584 Opioid Signalling BioSystems: REACTOME 2.703E-2 4.205E-2
1.820E-1
1.000E0
 1 85
28 1269803 Regulation of PLK1 Activity at G2/M Transition BioSystems: REACTOME 2.861E-2 4.291E-2
1.857E-1
1.000E0
 1 90
29 1269512 RHO GTPases activate PKNs BioSystems: REACTOME 2.986E-2 4.325E-2
1.871E-1
1.000E0
 1 94
Show 24 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 338 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 29048604 Influence of DARPP-32 genetic variation on BOLD activation to happy faces. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
2 25846879 The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
3 7581368 A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
4 16431080 Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
5 15522888 Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
6 19463699 The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
7 16061638 Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
8 15188007 DARPP-32 expression arises after a phase of dysplasia in oesophageal squamous cell carcinoma. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
9 21821092 Profiles of DARPP-32 in the insular cortex with schizophrenia: a postmortem brain study. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
10 12941760 Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
11 22777184 Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
12 10103106 Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
13 1791981 Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
14 24058659 Spatial distribution of DARPP-32 in dendritic spines. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
15 8838322 Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
16 11150351 Motivational effects of ethanol in DARPP-32 knock-out mice. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
17 11722604 Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
18 25692798 Dendritic geometry shapes neuronal cAMP signalling to the nucleus. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
19 19050854 A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
20 22179181 Detailed DARPP-32 expression profiles in postmortem brains from patients with schizophrenia: an immunohistochemical study. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
21 11812771 KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
22 17171661 Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
23 15657149 Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
24 18055181 Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
25 18234908 Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
26 21453742 Altered DARPP-32 expression in the superior temporal gyrus in schizophrenia. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
27 1721636 Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
28 18232732 A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
29 17596448 Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
30 21738631 A PTG variant contributes to a milder phenotype in Lafora disease. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
31 27995567 Associations Between PPP1R1B Gene Polymorphisms and Anxiety Levels in the Chinese Population. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
32 11880652 DARPP-32 mediates serotonergic neurotransmission in the forebrain. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
33 18579663 Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
34 6319627 DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
35 1533862 Regional distribution of DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA in mouse brain. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
36 16971527 DARPP-32 involvement in the photic pathway of the circadian system. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
37 16750903 Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
38 2191086 Distribution of DARPP-32 in the basal ganglia: an electron microscopic study. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
39 10837805 DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
40 10606530 A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
41 10669419 Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
42 23906769 Methylphenidate restores novel object recognition in DARPP-32 knockout mice. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
43 21369787 Association between DARPP-32 gene polymorphism and personality traits in healthy Chinese-Han subjects. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
44 11522787 The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
45 7926294 Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
46 9726244 A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
47 14767904 [Study on association of PPP1R3 gene 5 bp deletion/insertion within 3'-untranslated region polymorphism with type 2 diabetes]. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
48 17257813 The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
49 16525043 Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
50 11069952 Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. Pubmed 1.571E-4 4.116E-4 2.635E-3
5.310E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 108 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PPP1CB PPP1CB interactions 8.134E-5 8.785E-3 4.624E-2 8.785E-3 3 287
2 int:PPP1CA PPP1CA interactions 1.728E-4 9.333E-3 4.913E-2 1.867E-2 3 370
3 int:ACTBL2 ACTBL2 interactions 1.388E-3 3.110E-2
1.637E-1
1.499E-1
 2 173
4 int:PPP1R14C PPP1R14C interactions 2.032E-3 3.110E-2
1.637E-1
2.195E-1
 1 6
5 int:GYS2 GYS2 interactions 2.370E-3 3.110E-2
1.637E-1
2.560E-1
 1 7
6 int:PTGES3L-AARSD1 PTGES3L-AARSD1 interactions 2.709E-3 3.110E-2
1.637E-1
2.925E-1
 1 8
7 int:PPP1R3D PPP1R3D interactions 2.709E-3 3.110E-2
1.637E-1
2.925E-1
 1 8
8 int:PPP1R14B PPP1R14B interactions 3.047E-3 3.110E-2
1.637E-1
3.291E-1
 1 9
9 int:C20orf27 C20orf27 interactions 3.385E-3 3.110E-2
1.637E-1
3.656E-1
 1 10
10 int:KLHL6 KLHL6 interactions 3.723E-3 3.110E-2
1.637E-1
4.021E-1
 1 11
11 int:PPP1R1B PPP1R1B interactions 4.061E-3 3.110E-2
1.637E-1
4.386E-1
 1 12
12 int:PPP1R11 PPP1R11 interactions 4.399E-3 3.110E-2
1.637E-1
4.750E-1
 1 13
13 int:HSD17B6 HSD17B6 interactions 4.736E-3 3.110E-2
1.637E-1
5.115E-1
 1 14
14 int:PPP1CC PPP1CC interactions 5.063E-3 3.110E-2
1.637E-1
5.468E-1
 2 334
15 int:PLN PLN interactions 5.074E-3 3.110E-2
1.637E-1
5.480E-1
 1 15
16 int:CNST CNST interactions 5.074E-3 3.110E-2
1.637E-1
5.480E-1
 1 15
17 int:NHLRC1 NHLRC1 interactions 5.411E-3 3.110E-2
1.637E-1
5.844E-1
 1 16
18 int:TXNRD2 TXNRD2 interactions 5.749E-3 3.110E-2
1.637E-1
6.209E-1
 1 17
19 int:GYG1 GYG1 interactions 7.097E-3 3.110E-2
1.637E-1
7.665E-1
 1 21
20 int:PPP1R12B PPP1R12B interactions 7.434E-3 3.110E-2
1.637E-1
8.029E-1
 1 22
21 int:CDCA2 CDCA2 interactions 7.434E-3 3.110E-2
1.637E-1
8.029E-1
 1 22
22 int:DLGAP4 DLGAP4 interactions 7.434E-3 3.110E-2
1.637E-1
8.029E-1
 1 22
23 int:SHOC2 SHOC2 interactions 7.434E-3 3.110E-2
1.637E-1
8.029E-1
 1 22
24 int:STBD1 STBD1 interactions 7.771E-3 3.110E-2
1.637E-1
8.393E-1
 1 23
25 int:TPRN TPRN interactions 8.444E-3 3.110E-2
1.637E-1
9.120E-1
 1 25
26 int:PEAK1 PEAK1 interactions 8.444E-3 3.110E-2
1.637E-1
9.120E-1
 1 25
27 int:ROBO2 ROBO2 interactions 8.444E-3 3.110E-2
1.637E-1
9.120E-1
 1 25
28 int:EPM2A EPM2A interactions 8.444E-3 3.110E-2
1.637E-1
9.120E-1
 1 25
29 int:PHKB PHKB interactions 8.781E-3 3.110E-2
1.637E-1
9.483E-1
 1 26
30 int:NUAK1 NUAK1 interactions 9.117E-3 3.110E-2
1.637E-1
9.847E-1
 1 27
31 int:KIF18A KIF18A interactions 9.454E-3 3.110E-2
1.637E-1
1.000E0
 1 28
32 int:PPP1R3C PPP1R3C interactions 9.454E-3 3.110E-2
1.637E-1
1.000E0
 1 28
33 int:PPP1R13L PPP1R13L interactions 9.790E-3 3.110E-2
1.637E-1
1.000E0
 1 29
34 int:SAP25 SAP25 interactions 9.790E-3 3.110E-2
1.637E-1
1.000E0
 1 29
35 int:CD14 CD14 interactions 1.080E-2 3.164E-2
1.666E-1
1.000E0
 1 32
36 int:SEPT10 SEPT10 interactions 1.080E-2 3.164E-2
1.666E-1
1.000E0
 1 32
37 int:LMTK2 LMTK2 interactions 1.113E-2 3.164E-2
1.666E-1
1.000E0
 1 33
38 int:GNG5 GNG5 interactions 1.113E-2 3.164E-2
1.666E-1
1.000E0
 1 33
39 int:HMGCS1 HMGCS1 interactions 1.147E-2 3.176E-2
1.672E-1
1.000E0
 1 34
40 int:AASDHPPT AASDHPPT interactions 1.214E-2 3.252E-2
1.712E-1
1.000E0
 1 36
41 int:GYS1 GYS1 interactions 1.281E-2 3.252E-2
1.712E-1
1.000E0
 1 38
42 int:IL16 IL16 interactions 1.382E-2 3.252E-2
1.712E-1
1.000E0
 1 41
43 int:PRKG1 PRKG1 interactions 1.415E-2 3.252E-2
1.712E-1
1.000E0
 1 42
44 int:PPP1R9A PPP1R9A interactions 1.415E-2 3.252E-2
1.712E-1
1.000E0
 1 42
45 int:PPP1R10 PPP1R10 interactions 1.415E-2 3.252E-2
1.712E-1
1.000E0
 1 42
46 int:FKBP6 FKBP6 interactions 1.415E-2 3.252E-2
1.712E-1
1.000E0
 1 42
47 int:PDRG1 PDRG1 interactions 1.449E-2 3.252E-2
1.712E-1
1.000E0
 1 43
48 int:LACRT LACRT interactions 1.549E-2 3.252E-2
1.712E-1
1.000E0
 1 46
49 int:PPP1R3A PPP1R3A interactions 1.583E-2 3.252E-2
1.712E-1
1.000E0
 1 47
50 int:ZFYVE9 ZFYVE9 interactions 1.583E-2 3.252E-2
1.712E-1
1.000E0
 1 47
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q24.3-q25.3 6q24.3-q25.3 1.731E-4 1.039E-3 2.545E-3 1.039E-3 1 1
2 10q23-q24 10q23-q24 1.557E-3 4.671E-3 1.144E-2 9.342E-3 1 9
3 7q31.1 7q31.1 3.975E-3 7.950E-3 1.948E-2 2.385E-2 1 23
4 17q12 17q12 1.804E-2 2.042E-2
5.004E-2
1.082E-1
 1 105
5 1q32.1 1q32.1 1.957E-2 2.042E-2
5.004E-2
1.174E-1
 1 114
6 11q13 11q13 2.042E-2 2.042E-2
5.004E-2
1.225E-1
 1 119
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 56 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 694 Protein phosphatase 1 regulatory subunits genenames.org 8.923E-13 1.785E-12 2.677E-12 1.785E-12 6 181

13: Coexpression [Display Chart] 6 input genes in category / 510 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19286929-SuppTable2n Mouse Lung Rangasamy09 254genes GeneSigDB 1.639E-7 8.358E-5 5.694E-4 8.358E-5 4 239
2 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 2.722E-6 6.941E-4 4.728E-3 1.388E-3 4 483
3 19658189-TableS9a Human EmbryonicStemCell Xu09 34genes GeneSigDB 2.949E-5 5.003E-3 3.408E-2 1.504E-2 2 33
4 12874079-Table3f Human HeadandNeck Sok03 45genes GeneSigDB 3.924E-5 5.003E-3 3.408E-2 2.001E-2 2 38
5 M6278 Genes up-regulated in medullary thymic epithelial cells (mTEC) with CD80 [GeneID=941] low: AIRE [GeneID=326] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 3.971E-2
2.705E-1
5.395E-1
 2 197
6 M10033 Genes down-regulated in macrophages: control versus colorectal adenocarcinoma conditioned. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 3.971E-2
2.705E-1
5.504E-1
 2 199
7 M3289 Genes up-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 21 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 3.971E-2
2.705E-1
5.504E-1
 2 199
8 M6456 Genes up-regulated in T cells: CD4 [GeneID=920] versus CD8A [GeneID=925]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
9 M7902 Genes up-regulated in monocytes (12h) versus macrophages (12h) treated with IFNG, TNF [GeneID=3458;7124] and rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
10 M7843 Genes down-regulated in T conv cells treated with IL35 versus resting T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
11 M9205 Genes up-regulated in CD8 T cells: wildtype versus STAT1 [GeneID=6772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
12 M7055 Genes down-regulated in hematopoietic stem cells versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
13 M3931 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
14 M8259 Genes down-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 16h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 3.971E-2
2.705E-1
5.559E-1
 2 200
15 M1585 Genes down-regulated in HUVEC cells (umbilical vein endothelium) by fenretinide [PubChem=1744]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 4.407E-2
3.002E-1
6.610E-1
 1 5
16 M2444 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 1 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.555E-3 4.957E-2
3.377E-1
7.931E-1
 1 6
Show 11 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 643 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 geo heart 500 K4 geo heart top-relative-expression-ranked 500 k-means-cluster#4 PCBC 5.202E-6 3.345E-3 2.356E-2 3.345E-3 3 141
2 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Yolk Sac Tumor/3/4 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Yolk Sac Tumor/3/4 TCGA-Testes 1.922E-4 4.835E-2
3.406E-1
1.236E-1
 2 79
3 PCBC ctl geo-heart 500 geo heart top-relative-expression-ranked 500 PCBC 2.256E-4 4.835E-2
3.406E-1
1.450E-1
 3 499

15: Computational [Display Chart] 3 input genes in category / 29 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 205 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1243:PITA hsa-miR-1243:PITA TOP PITA 6.822E-5 9.133E-3
5.391E-2
 1.399E-2 2 155
2 hsa-miR-556-3p:PITA hsa-miR-556-3p:PITA TOP PITA 1.025E-4 9.133E-3
5.391E-2
 2.101E-2 2 190
3 hsa-miR-595:PITA hsa-miR-595:PITA TOP PITA 1.337E-4 9.133E-3
5.391E-2
 2.740E-2 2 217
4 hsa-miR-125b-1*:mirSVR lowEffct hsa-miR-125b-1*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.018E-4 1.925E-2
1.136E-1
8.237E-2
 2 377
5 hsa-miR-3130-3p:mirSVR highEffct hsa-miR-3130-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.512E-4 1.925E-2
1.136E-1
1.130E-1
 2 442
6 hsa-miR-103-as:mirSVR highEffct hsa-miR-103-as:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.915E-4 1.925E-2
1.136E-1
1.213E-1
 2 458
7 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 6.574E-4 1.925E-2
1.136E-1
1.348E-1
 2 483
8 hsa-miR-6840-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.660E-3 3.566E-2
2.105E-1
3.403E-1
 1 20
9 hsa-miR-6886-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.992E-3 3.566E-2
2.105E-1
4.083E-1
 1 24
10 hsa-miR-151-5p:PITA hsa-miR-151-5p:PITA TOP PITA 2.489E-3 3.566E-2
2.105E-1
5.103E-1
 1 30
11 hsa-miR-4661-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.235E-3 3.566E-2
2.105E-1
6.632E-1
 1 39
12 hsa-miR-5089-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.649E-3 3.566E-2
2.105E-1
7.480E-1
 1 44
13 hsa-miR-5681b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 3.566E-2
2.105E-1
9.008E-1
 1 53
14 hsa-miR-885-3p:PITA hsa-miR-885-3p:PITA TOP PITA 4.560E-3 3.566E-2
2.105E-1
9.347E-1
 1 55
15 hsa-miR-3181:mirSVR highEffct hsa-miR-3181:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.139E-3 3.566E-2
2.105E-1
1.000E0
 1 62
16 hsa-miR-4420:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 3.566E-2
2.105E-1
1.000E0
 1 65
17 hsa-miR-181b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 3.566E-2
2.105E-1
1.000E0
 1 67
18 hsa-miR-181b-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 3.566E-2
2.105E-1
1.000E0
 1 67
19 hsa-miR-134-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 3.566E-2
2.105E-1
1.000E0
 1 67
20 hsa-miR-659-3p:Functional MTI Functional MTI miRTarbase 5.635E-3 3.566E-2
2.105E-1
1.000E0
 1 68
21 hsa-miR-653-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 3.566E-2
2.105E-1
1.000E0
 1 68
22 hsa-miR-6823-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.883E-3 3.566E-2
2.105E-1
1.000E0
 1 71
23 hsa-miR-7114-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.566E-2
2.105E-1
1.000E0
 1 73
24 hsa-miR-2114-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.566E-2
2.105E-1
1.000E0
 1 75
25 hsa-miR-1911-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.566E-2
2.105E-1
1.000E0
 1 75
26 hsa-miR-453:PITA hsa-miR-453:PITA TOP PITA 6.213E-3 3.566E-2
2.105E-1
1.000E0
 1 75
27 hsa-miR-191-5p:Functional MTI Functional MTI miRTarbase 6.461E-3 3.566E-2
2.105E-1
1.000E0
 1 78
28 hsa-miR-6757-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.626E-3 3.566E-2
2.105E-1
1.000E0
 1 80
29 hsa-miR-593-5p:Functional MTI Functional MTI miRTarbase 6.626E-3 3.566E-2
2.105E-1
1.000E0
 1 80
30 hsa-miR-1203:mirSVR highEffct hsa-miR-1203:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.709E-3 3.566E-2
2.105E-1
1.000E0
 1 81
31 hsa-miR-3166:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.566E-2
2.105E-1
1.000E0
 1 84
32 hsa-miR-187-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.566E-2
2.105E-1
1.000E0
 1 84
33 hsa-miR-4650-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.122E-3 3.566E-2
2.105E-1
1.000E0
 1 86
34 hsa-miR-6780b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.452E-3 3.566E-2
2.105E-1
1.000E0
 1 90
35 hsa-miR-92a-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 3.566E-2
2.105E-1
1.000E0
 1 91
36 hsa-miR-1233:PITA hsa-miR-1233:PITA TOP PITA 7.535E-3 3.566E-2
2.105E-1
1.000E0
 1 91
37 hsa-miR-571:PITA hsa-miR-571:PITA TOP PITA 7.617E-3 3.566E-2
2.105E-1
1.000E0
 1 92
38 hsa-miR-4780:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.617E-3 3.566E-2
2.105E-1
1.000E0
 1 92
39 hsa-miR-296-3p:PITA hsa-miR-296-3p:PITA TOP PITA 7.700E-3 3.566E-2
2.105E-1
1.000E0
 1 93
40 hsa-miR-596:PITA hsa-miR-596:PITA TOP PITA 7.782E-3 3.566E-2
2.105E-1
1.000E0
 1 94
41 hsa-miR-6866-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 3.566E-2
2.105E-1
1.000E0
 1 94
42 hsa-miR-6073:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 3.566E-2
2.105E-1
1.000E0
 1 95
43 hsa-miR-29a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.566E-2
2.105E-1
1.000E0
 1 98
44 hsa-miR-631:PITA hsa-miR-631:PITA TOP PITA 8.277E-3 3.566E-2
2.105E-1
1.000E0
 1 100
45 hsa-miR-33b-5p:Functional MTI Functional MTI miRTarbase 8.360E-3 3.566E-2
2.105E-1
1.000E0
 1 101
46 hsa-miR-4671-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.442E-3 3.566E-2
2.105E-1
1.000E0
 1 102
47 hsa-miR-4733-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.566E-2
2.105E-1
1.000E0
 1 103
48 hsa-miR-548v:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.566E-2
2.105E-1
1.000E0
 1 103
49 hsa-miR-520f-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.525E-3 3.566E-2
2.105E-1
1.000E0
 1 103
50 AGGAAGC,MIR-516-3P:MSigDB AGGAAGC,MIR-516-3P:MSigDB MSigDB 8.772E-3 3.570E-2
2.107E-1
1.000E0
 1 106
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1155 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000002534 NSC611747 Stitch 5.007E-9 5.783E-6 4.412E-5 5.783E-6 5 352
2 CID000440646 tautomycin Stitch 1.007E-8 5.816E-6 4.438E-5 1.163E-5 4 118
3 CID000914489 AC1LIZYF Stitch 4.289E-8 1.651E-5 1.260E-4 4.954E-5 4 169
4 CID000440188 pyridoxine-5'-beta-D-glucoside Stitch 1.609E-6 4.646E-4 3.545E-3 1.858E-3 2 8
5 CID000445433 microcystin-LR Stitch 3.477E-6 8.031E-4 6.127E-3 4.015E-3 3 129
6 CID011530041 inhibitor 1 Stitch 5.045E-6 9.712E-4 7.410E-3 5.827E-3 3 146
7 CID005327336 sulfonamide analog 1 Stitch 1.566E-5 2.585E-3 1.972E-2 1.809E-2 3 213
8 CID000444719 Methionine phosphonate Stitch 5.168E-5 7.461E-3
5.693E-2
5.969E-2
 2 43
9 CID000448772 32 P Stitch 1.064E-4 1.214E-2
9.259E-2
1.228E-1
 3 405
10 CID000439177 glycogen Stitch 1.388E-4 1.214E-2
9.259E-2
1.603E-1
 3 443
11 CID000000838 L-adrenaline Stitch 1.416E-4 1.214E-2
9.259E-2
1.635E-1
 3 446
12 CID006437077 AC1O5MYK Stitch 1.668E-4 1.214E-2
9.259E-2
1.926E-1
 2 77
13 CID000005396 AC-759 Stitch 2.179E-4 1.214E-2
9.259E-2
2.517E-1
 2 88
14 CID000124330 AC1L3Y9G Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
15 ctd:D056572 Histone Deacetylase Inhibitors CTD 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
16 ctd:C087141 2-(1-(4-piperonyl)piperazinyl)benzothiazole CTD 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
17 CID000637020 AC1LCTCG Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
18 CID000115321 phenobarbital N-glucoside Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
19 CID009908152 basiliskamide B Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
20 ctd:C083009 4-amino-1-(6-chloro-2-pyridyl)piperidine hydrochloride CTD 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
21 ctd:C406233 2-ethyl-5-methoxy-N,N-dimethyltryptamine CTD 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
22 CID000121536 himachalol Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
23 CID000146930 MBAMG Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
24 CID000467778 T-8581 Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
25 CID000031065 N-dichloroacetyl-DL-serine Stitch 2.627E-4 1.214E-2
9.259E-2
3.034E-1
 1 1
26 CID000003422 AC1L1FWE Stitch 2.928E-4 1.301E-2
9.923E-2
3.381E-1
 2 102
27 CID000126715 BADGH Stitch 5.253E-4 2.022E-2
1.543E-1
6.067E-1
 1 2
28 ctd:C072790 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester CTD 5.253E-4 2.022E-2
1.543E-1
6.067E-1
 1 2
29 CID000021997 10-methyl-9-aminoacridine Stitch 5.253E-4 2.022E-2
1.543E-1
6.067E-1
 1 2
30 ctd:C114163 Ro 4-6790 CTD 5.253E-4 2.022E-2
1.543E-1
6.067E-1
 1 2
31 CID000004217 ML-9 Stitch 6.067E-4 2.261E-2
1.725E-1
7.008E-1
 2 147
32 CID000155569 yunaconitine Stitch 7.879E-4 2.325E-2
1.774E-1
9.100E-1
 1 3
33 CID000196026 hATPA Stitch 7.879E-4 2.325E-2
1.774E-1
9.100E-1
 1 3
34 ctd:C075631 anpirtoline CTD 7.879E-4 2.325E-2
1.774E-1
9.100E-1
 1 3
35 CID000100632 WR-151327 Stitch 7.879E-4 2.325E-2
1.774E-1
9.100E-1
 1 3
36 CID000100269 RFCNU Stitch 7.879E-4 2.325E-2
1.774E-1
9.100E-1
 1 3
37 CID000107914 NSC114781 Stitch 7.879E-4 2.325E-2
1.774E-1
9.100E-1
 1 3
38 CID000008701 seson Stitch 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
39 ctd:C034643 naloxonazine CTD 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
40 ctd:C478058 N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine CTD 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
41 CID000121926 ZK 93423 Stitch 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
42 ctd:C114947 SR 142948 CTD 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
43 CID016122598 GN8 Stitch 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
44 ctd:D008735 5-Methoxytryptamine CTD 1.050E-3 2.325E-2
1.774E-1
1.000E0
 1 4
45 6705 DN Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 2.325E-2
1.774E-1
1.000E0
 2 194
46 4570 DN Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.074E-3 2.325E-2
1.774E-1
1.000E0
 2 196
47 7140 UP Picotamide monohydrate [80530-63-8]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.074E-3 2.325E-2
1.774E-1
1.000E0
 2 196
48 4547 DN Diethylstilbestrol [56-53-1]; Down 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.085E-3 2.325E-2
1.774E-1
1.000E0
 2 197
49 6669 DN Benzbromarone [3562-84-3]; Down 200; 9.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.085E-3 2.325E-2
1.774E-1
1.000E0
 2 197
50 7311 UP Tiletamine hydrochloride; Up 200; 15.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.085E-3 2.325E-2
1.774E-1
1.000E0
 2 197
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 71 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3274502 Opiate Withdrawal Syndrome DisGeNET BeFree 3.085E-4 1.460E-2
7.078E-2
 2.191E-2 1 1
2 OMIN:604367 LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3; FPLD3 OMIM 6.170E-4 1.460E-2
7.078E-2
 4.381E-2 1 2
3 cv:C1720861 Lipodystrophy, familial partial, type 3 Clinical Variations 6.170E-4 1.460E-2
7.078E-2
 4.381E-2 1 2
4 C1837785 Prominent superficial veins DisGeNET Curated 9.254E-4 1.643E-2
7.962E-2
6.570E-2
 1 3
5 C4024606 Loss of gluteal subcutaneous adipose tissue DisGeNET Curated 1.234E-3 1.752E-2
8.491E-2
8.759E-2
 1 4
6 C1837764 Loss of subcutaneous adipose tissue in limbs DisGeNET Curated 1.850E-3 1.806E-2
8.752E-2
1.314E-1
 1 6
7 C0029095 Opioid abuse DisGeNET BeFree 1.850E-3 1.806E-2
8.752E-2
1.314E-1
 1 6
8 C1290857 Disorder of face DisGeNET Curated 3.082E-3 1.806E-2
8.752E-2
2.188E-1
 1 10
9 C0151691 High density lipoprotein decreased DisGeNET Curated 3.082E-3 1.806E-2
8.752E-2
2.188E-1
 1 10
10 C0271650 Impaired glucose tolerance DisGeNET Curated 3.357E-3 1.806E-2
8.752E-2
2.384E-1
 2 303
11 C4025871 Abnormality of the face DisGeNET Curated 3.390E-3 1.806E-2
8.752E-2
2.407E-1
 1 11
12 C0858321 Plasmodium vivax infection DisGeNET BeFree 3.698E-3 1.806E-2
8.752E-2
2.625E-1
 1 12
13 C4020778 maternal hyperglycemia DisGeNET Curated 3.698E-3 1.806E-2
8.752E-2
2.625E-1
 1 12
14 C0085207 Gestational Diabetes DisGeNET Curated 3.698E-3 1.806E-2
8.752E-2
2.625E-1
 1 12
15 C1857657 Decreased subcutaneous adipose tissue DisGeNET Curated 4.005E-3 1.806E-2
8.752E-2
2.844E-1
 1 13
16 C0271694 Familial partial lipodystrophy DisGeNET Curated 4.313E-3 1.806E-2
8.752E-2
3.062E-1
 1 14
17 C0852733 Completed Suicide DisGeNET BeFree 4.928E-3 1.806E-2
8.752E-2
3.499E-1
 1 16
18 C4021745 Abnormality of the musculature DisGeNET Curated 4.928E-3 1.806E-2
8.752E-2
3.499E-1
 1 16
19 C4280628 Malformation of the neck DisGeNET Curated 5.849E-3 1.806E-2
8.752E-2
4.153E-1
 1 19
20 C0473527 Hypoalphalipoproteinemias DisGeNET Curated 5.849E-3 1.806E-2
8.752E-2
4.153E-1
 1 19
21 C0575167 Deformity of neck DisGeNET Curated 5.849E-3 1.806E-2
8.752E-2
4.153E-1
 1 19
22 C0028949 Oligomenorrhea DisGeNET Curated 5.849E-3 1.806E-2
8.752E-2
4.153E-1
 1 19
23 C0266623 Congenital anomaly of neck DisGeNET Curated 5.849E-3 1.806E-2
8.752E-2
4.153E-1
 1 19
24 C0854110 Insulin resistant diabetes DisGeNET Curated 6.770E-3 2.003E-2
9.708E-2
4.807E-1
 1 22
25 C0032914 Pre-Eclampsia DisGeNET Curated 7.691E-3 2.100E-2
1.018E-1
5.461E-1
 1 25
26 C0007370 Catalepsy DisGeNET Curated 7.691E-3 2.100E-2
1.018E-1
5.461E-1
 1 25
27 C2931859 Acquired CJD DisGeNET BeFree 8.611E-3 2.261E-2
1.096E-1
6.114E-1
 1 28
28 C0000889 Acanthosis Nigricans DisGeNET Curated 8.917E-3 2.261E-2
1.096E-1
6.331E-1
 1 29
29 C0038580 Substance Dependence DisGeNET BeFree 1.014E-2 2.473E-2
1.198E-1
7.201E-1
 1 33
30 OMIN:125853 DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM OMIM 1.045E-2 2.473E-2
1.198E-1
7.418E-1
 1 34
31 C1522137 Hypertriglyceridemia result DisGeNET Curated 1.137E-2 2.603E-2
1.262E-1
8.070E-1
 1 37
32 C0524662 Opiate Addiction DisGeNET BeFree 1.320E-2 2.922E-2
1.416E-1
9.371E-1
 1 43
33 C0019572 Hirsutism DisGeNET Curated 1.442E-2 2.922E-2
1.416E-1
1.000E0
 1 47
34 C0233523 Antisocial behavior DisGeNET BeFree 1.472E-2 2.922E-2
1.416E-1
1.000E0
 1 48
35 C0233565 Bradykinesia DisGeNET Curated 1.503E-2 2.922E-2
1.416E-1
1.000E0
 1 49
36 C0686347 Tardive Dyskinesia DisGeNET BeFree 1.533E-2 2.922E-2
1.416E-1
1.000E0
 1 50
37 C3714760 Drug-induced tardive dyskinesia DisGeNET BeFree 1.533E-2 2.922E-2
1.416E-1
1.000E0
 1 50
38 C0751783 Lafora Disease DisGeNET Curated 1.564E-2 2.922E-2
1.416E-1
1.000E0
 1 51
39 C0038587 Substance Withdrawal Syndrome DisGeNET Curated 1.747E-2 3.180E-2
1.541E-1
1.000E0
 1 57
40 C0740394 Hyperuricemia DisGeNET Curated 1.838E-2 3.262E-2
1.581E-1
1.000E0
 1 60
41 C0013384 Dyskinetic syndrome DisGeNET Curated 1.929E-2 3.312E-2
1.605E-1
1.000E0
 1 63
42 C1510472 Drug Dependence DisGeNET BeFree 1.959E-2 3.312E-2
1.605E-1
1.000E0
 1 64
43 C0232939 Primary physiologic amenorrhea DisGeNET Curated 2.020E-2 3.336E-2
1.617E-1
1.000E0
 1 66
44 C0242723 Parasitemia DisGeNET BeFree 2.202E-2 3.475E-2
1.684E-1
1.000E0
 1 72
45 C0021655 Insulin Resistance DisGeNET Curated 2.202E-2 3.475E-2
1.684E-1
1.000E0
 1 72
46 C0024408 Machado-Joseph Disease DisGeNET Curated 2.263E-2 3.493E-2
1.693E-1
1.000E0
 1 74
47 C0398623 Thrombophilia DisGeNET Curated 2.626E-2 3.967E-2
1.923E-1
1.000E0
 1 86
48 C0023787 Lipodystrophy DisGeNET Curated 2.988E-2 4.416E-2
2.141E-1
1.000E0
 1 98
49 C0266617 Congenital anomaly of face DisGeNET Curated 3.048E-2 4.416E-2
2.141E-1
1.000E0
 1 100
Show 44 more annotations