Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc269_5, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 5 input genes in category / 11 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004842 ubiquitin-protein transferase activity 1.173E-6 8.305E-6 2.508E-5 1.290E-5 4 414
2 GO:0019787 ubiquitin-like protein transferase activity 1.510E-6 8.305E-6 2.508E-5 1.661E-5 4 441
3 GO:0097602 cullin family protein binding 3.787E-6 1.388E-5 4.193E-5 4.165E-5 2 12
4 GO:0061630 ubiquitin protein ligase activity 1.422E-5 3.354E-5 1.013E-4 1.564E-4 3 212
5 GO:0061659 ubiquitin-like protein ligase activity 1.524E-5 3.354E-5 1.013E-4 1.677E-4 3 217
6 GO:0019788 NEDD8 transferase activity 1.071E-3 1.964E-3 5.932E-3 1.179E-2 1 4
7 GO:0031625 ubiquitin protein ligase binding 2.071E-3 2.931E-3 8.851E-3 2.278E-2 2 273
8 GO:0044389 ubiquitin-like protein ligase binding 2.132E-3 2.931E-3 8.851E-3 2.345E-2 2 277
9 GO:0034450 ubiquitin-ubiquitin ligase activity 3.479E-3 4.252E-3 1.284E-2 3.827E-2 1 13
10 GO:0008013 beta-catenin binding 2.362E-2 2.598E-2
7.847E-2
2.598E-1
 1 89
Show 5 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 171 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1.643E-8 2.809E-6 1.607E-5 2.809E-6 3 23
2 GO:0006513 protein monoubiquitination 2.295E-7 1.962E-5 1.123E-4 3.925E-5 3 54
3 GO:1904668 positive regulation of ubiquitin protein ligase activity 7.878E-7 3.897E-5 2.230E-4 1.347E-4 3 81
4 GO:1904666 regulation of ubiquitin protein ligase activity 9.116E-7 3.897E-5 2.230E-4 1.559E-4 3 85
5 GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 1.158E-6 3.962E-5 2.267E-4 1.981E-4 3 92
6 GO:0051443 positive regulation of ubiquitin-protein transferase activity 1.630E-6 3.982E-5 2.278E-4 2.787E-4 3 103
7 GO:2000058 regulation of ubiquitin-dependent protein catabolic process 1.630E-6 3.982E-5 2.278E-4 2.787E-4 3 103
8 GO:0051351 positive regulation of ligase activity 1.934E-6 4.134E-5 2.365E-4 3.307E-4 3 109
9 GO:0051438 regulation of ubiquitin-protein transferase activity 2.585E-6 4.762E-5 2.725E-4 4.420E-4 3 120
10 GO:0051340 regulation of ligase activity 2.785E-6 4.762E-5 2.725E-4 4.762E-4 3 123
11 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 8.755E-6 1.361E-4 7.787E-4 1.497E-3 3 180
12 GO:0031398 positive regulation of protein ubiquitination 1.014E-5 1.442E-4 8.250E-4 1.733E-3 3 189
13 GO:1903364 positive regulation of cellular protein catabolic process 1.096E-5 1.442E-4 8.250E-4 1.874E-3 3 194
14 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 1.312E-5 1.603E-4 9.172E-4 2.244E-3 3 206
15 GO:0000209 protein polyubiquitination 2.457E-5 2.741E-4 1.568E-3 4.202E-3 3 254
16 GO:0031396 regulation of protein ubiquitination 2.853E-5 2.741E-4 1.568E-3 4.878E-3 3 267
17 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 2.853E-5 2.741E-4 1.568E-3 4.878E-3 3 267
18 GO:0045732 positive regulation of protein catabolic process 2.885E-5 2.741E-4 1.568E-3 4.933E-3 3 268
19 GO:1903362 regulation of cellular protein catabolic process 3.540E-5 3.122E-4 1.787E-3 6.054E-3 3 287
20 GO:1903320 regulation of protein modification by small protein conjugation or removal 3.652E-5 3.122E-4 1.787E-3 6.245E-3 3 290
21 GO:1901990 regulation of mitotic cell cycle phase transition 4.808E-5 3.915E-4 2.240E-3 8.223E-3 3 318
22 GO:1901987 regulation of cell cycle phase transition 5.768E-5 4.483E-4 2.565E-3 9.863E-3 3 338
23 GO:0031331 positive regulation of cellular catabolic process 6.510E-5 4.840E-4 2.769E-3 1.113E-2 3 352
24 GO:0045862 positive regulation of proteolysis 8.240E-5 5.871E-4 3.359E-3 1.409E-2 3 381
25 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 9.037E-5 6.181E-4 3.537E-3 1.545E-2 3 393
26 GO:0009896 positive regulation of catabolic process 1.055E-4 6.682E-4 3.823E-3 1.804E-2 3 414
27 GO:0042176 regulation of protein catabolic process 1.055E-4 6.682E-4 3.823E-3 1.804E-2 3 414
28 GO:0010498 proteasomal protein catabolic process 1.117E-4 6.821E-4 3.903E-3 1.910E-2 3 422
29 GO:0016055 Wnt signaling pathway 1.783E-4 1.051E-3 6.015E-3 3.049E-2 3 494
30 GO:0002223 stimulatory C-type lectin receptor signaling pathway 3.055E-4 1.741E-3 9.964E-3
5.224E-2
 2 104
31 GO:0002220 innate immune response activating cell surface receptor signaling pathway 3.234E-4 1.784E-3 1.021E-2
5.530E-2
 2 107
32 GO:0038061 NIK/NF-kappaB signaling 3.998E-4 2.137E-3 1.223E-2
6.837E-2
 2 119
33 GO:0007057 spindle assembly involved in female meiosis I 5.369E-4 2.782E-3 1.592E-2
9.181E-2
 1 2
34 GO:0038095 Fc-epsilon receptor signaling pathway 5.687E-4 2.860E-3 1.637E-2
9.725E-2
 2 142
35 GO:0007056 spindle assembly involved in female meiosis 8.053E-4 3.934E-3 2.251E-2
1.377E-1
 1 3
36 GO:0050852 T cell receptor signaling pathway 8.618E-4 4.094E-3 2.342E-2
1.474E-1
 2 175
37 GO:0000086 G2/M transition of mitotic cell cycle 1.090E-3 5.039E-3 2.883E-2
1.864E-1
 2 197
38 GO:0044839 cell cycle G2/M phase transition 1.180E-3 5.223E-3 2.989E-2
2.017E-1
 2 205
39 GO:0038093 Fc receptor signaling pathway 1.191E-3 5.223E-3 2.989E-2
2.037E-1
 2 206
40 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation 1.342E-3 5.736E-3 3.282E-2
2.295E-1
 1 5
41 GO:0050851 antigen receptor-mediated signaling pathway 1.520E-3 6.341E-3 3.628E-2
2.600E-1
 2 233
42 GO:0007144 female meiosis I 1.610E-3 6.403E-3 3.664E-2
2.753E-1
 1 6
43 GO:0060903 positive regulation of meiosis I 1.610E-3 6.403E-3 3.664E-2
2.753E-1
 1 6
44 GO:0000082 G1/S transition of mitotic cell cycle 1.706E-3 6.536E-3 3.740E-2
2.918E-1
 2 247
45 GO:0002758 innate immune response-activating signal transduction 1.720E-3 6.536E-3 3.740E-2
2.941E-1
 2 248
46 GO:0002218 activation of innate immune response 1.832E-3 6.691E-3 3.828E-2
3.132E-1
 2 256
47 GO:0044843 cell cycle G1/S phase transition 1.846E-3 6.691E-3 3.828E-2
3.156E-1
 2 257
48 GO:0090306 spindle assembly involved in meiosis 1.878E-3 6.691E-3 3.828E-2
3.212E-1
 1 7
49 GO:0051403 stress-activated MAPK cascade 2.065E-3 7.205E-3 4.122E-2
3.530E-1
 2 272
50 GO:0031098 stress-activated protein kinase signaling cascade 2.155E-3 7.371E-3 4.218E-2
3.686E-1
 2 278
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 23 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019005 SCF ubiquitin ligase complex 5.349E-11 1.230E-9 4.595E-9 1.230E-9 4 36
2 GO:0031461 cullin-RING ubiquitin ligase complex 2.036E-8 2.342E-7 8.744E-7 4.683E-7 4 154
3 GO:0000151 ubiquitin ligase complex 2.065E-7 1.584E-6 5.913E-6 4.751E-6 4 274
4 GO:0031467 Cul7-RING ubiquitin ligase complex 5.503E-7 3.164E-6 1.182E-5 1.266E-5 2 5
5 GO:0043224 nuclear SCF ubiquitin ligase complex 5.246E-4 2.413E-3 9.011E-3 1.207E-2 1 2
6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex 7.868E-4 3.016E-3 1.126E-2 1.810E-2 1 3
7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex 1.311E-3 4.308E-3 1.609E-2 3.015E-2 1 5
8 GO:0031466 Cul5-RING ubiquitin ligase complex 1.573E-3 4.523E-3 1.689E-2 3.618E-2 1 6
9 GO:0030891 VCB complex 2.097E-3 5.359E-3 2.001E-2 4.823E-2 1 8
10 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 2.359E-3 5.425E-3 2.026E-2
5.425E-2
 1 9
11 GO:0031462 Cul2-RING ubiquitin ligase complex 2.882E-3 6.027E-3 2.251E-2
6.630E-2
 1 11
12 GO:0000153 cytoplasmic ubiquitin ligase complex 3.929E-3 7.531E-3 2.812E-2
9.037E-2
 1 15
13 GO:0080008 Cul4-RING E3 ubiquitin ligase complex 6.541E-3 1.157E-2 4.322E-2
1.505E-1
 1 25
14 GO:0000152 nuclear ubiquitin ligase complex 1.097E-2 1.802E-2
6.728E-2
2.523E-1
 1 42
15 GO:0031519 PcG protein complex 1.175E-2 1.802E-2
6.728E-2
2.702E-1
 1 45
16 GO:0031463 Cul3-RING ubiquitin ligase complex 1.694E-2 2.435E-2
9.092E-2
3.895E-1
 1 65
17 GO:0030018 Z disc 3.083E-2 4.171E-2
1.558E-1
7.091E-1
 1 119
18 GO:0031674 I band 3.492E-2 4.462E-2
1.666E-1
8.031E-1
 1 135
Show 13 more annotations

4: Human Phenotype [Display Chart] 0 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3 input genes in category / 21 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004064 decreased susceptibility to induced muscular atrophy 1.159E-3 2.433E-2
8.869E-2
 2.433E-2 1 4

6: Domain [Display Chart] 5 input genes in category / 32 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS50181 FBOX PROSITE 1.446E-4 1.553E-3 6.301E-3 4.626E-3 2 72
2 IPR001810 F-box dom InterPro 1.569E-4 1.553E-3 6.301E-3 5.021E-3 2 75
3 IPR016897 SKP1 InterPro 2.669E-4 1.553E-3 6.301E-3 8.540E-3 1 1
4 IPR016072 Skp1 comp dimer InterPro 2.669E-4 1.553E-3 6.301E-3 8.540E-3 1 1
5 PF01466 Skp1 Pfam 2.669E-4 1.553E-3 6.301E-3 8.540E-3 1 1
6 PF03931 Skp1 POZ Pfam 5.337E-4 1.553E-3 6.301E-3 1.708E-2 1 2
7 SM00512 Skp1 SMART 5.337E-4 1.553E-3 6.301E-3 1.708E-2 1 2
8 IPR001232 SKP1-like InterPro 5.337E-4 1.553E-3 6.301E-3 1.708E-2 1 2
9 IPR024766 Znf RING H2 InterPro 5.337E-4 1.553E-3 6.301E-3 1.708E-2 1 2
10 PF12678 zf-rbx1 Pfam 5.337E-4 1.553E-3 6.301E-3 1.708E-2 1 2
11 IPR016073 Skp1 comp POZ InterPro 5.337E-4 1.553E-3 6.301E-3 1.708E-2 1 2
12 SM00182 CULLIN SMART 1.867E-3 4.063E-3 1.649E-2
5.974E-2
 1 7
13 IPR016157 Cullin CS InterPro 1.867E-3 4.063E-3 1.649E-2
5.974E-2
 1 7
14 IPR019559 Cullin neddylation domain InterPro 2.133E-3 4.063E-3 1.649E-2
6.827E-2
 1 8
15 PF10557 Cullin Nedd8 Pfam 2.133E-3 4.063E-3 1.649E-2
6.827E-2
 1 8
16 SM00884 Cullin Nedd8 SMART 2.133E-3 4.063E-3 1.649E-2
6.827E-2
 1 8
17 IPR016158 Cullin homology InterPro 2.400E-3 4.063E-3 1.649E-2
7.680E-2
 1 9
18 IPR001373 Cullin N InterPro 2.666E-3 4.063E-3 1.649E-2
8.532E-2
 1 10
19 PS01256 CULLIN 1 PROSITE 2.666E-3 4.063E-3 1.649E-2
8.532E-2
 1 10
20 PF00888 Cullin Pfam 2.666E-3 4.063E-3 1.649E-2
8.532E-2
 1 10
21 PS50069 CULLIN 2 PROSITE 2.666E-3 4.063E-3 1.649E-2
8.532E-2
 1 10
22 IPR016159 Cullin repeat-like dom InterPro 3.199E-3 4.653E-3 1.888E-2
1.024E-1
 1 12
23 PF00646 F-box Pfam 1.776E-2 2.470E-2
1.003E-1
5.682E-1
 1 67
Show 18 more annotations

7: Pathway [Display Chart] 5 input genes in category / 163 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268893 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling BioSystems: REACTOME 3.109E-10 2.534E-8 1.438E-7 5.068E-8 3 5
2 1268892 FBXW7 Mutants and NOTCH1 in Cancer BioSystems: REACTOME 3.109E-10 2.534E-8 1.438E-7 5.068E-8 3 5
3 M17977 Regulation of p27 Phosphorylation during Cell Cycle Progression MSigDB C2 BIOCARTA (v6.0) 8.884E-9 4.827E-7 2.739E-6 1.448E-6 3 13
4 1269328 Prolactin receptor signaling BioSystems: REACTOME 1.739E-8 7.086E-7 4.020E-6 2.834E-6 3 16
5 126909 Oocyte meiosis BioSystems: KEGG 4.652E-8 1.516E-6 8.604E-6 7.582E-6 4 124
6 83084 Circadian rhythm BioSystems: KEGG 1.393E-7 3.785E-6 2.148E-5 2.271E-5 3 31
7 1269537 NOTCH1 Intracellular Domain Regulates Transcription BioSystems: REACTOME 5.350E-7 1.110E-5 6.297E-5 8.720E-5 3 48
8 1268890 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
9 1269841 SCF-beta-TrCP mediated degradation of Emi1 BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
10 1457807 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
11 1268891 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
12 1268889 Constitutive Signaling by NOTCH1 PEST Domain Mutants BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
13 1268888 Signaling by NOTCH1 PEST Domain Mutants in Cancer BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
14 1268883 Signaling by NOTCH1 in Cancer BioSystems: REACTOME 9.532E-7 1.110E-5 6.297E-5 1.554E-4 3 58
15 1269638 Degradation of GLI2 by the proteasome BioSystems: REACTOME 1.226E-6 1.233E-5 6.997E-5 1.998E-4 3 63
16 1269637 GLI3 is processed to GLI3R by the proteasome BioSystems: REACTOME 1.226E-6 1.233E-5 6.997E-5 1.998E-4 3 63
17 1269639 Degradation of GLI1 by the proteasome BioSystems: REACTOME 1.286E-6 1.233E-5 6.997E-5 2.097E-4 3 64
18 1269193 Antigen processing: Ubiquitination & Proteasome degradation BioSystems: REACTOME 1.946E-6 1.715E-5 9.729E-5 3.172E-4 4 314
19 1269535 Signaling by NOTCH1 BioSystems: REACTOME 1.999E-6 1.715E-5 9.729E-5 3.258E-4 3 74
20 1269839 Regulation of APC/C activators between G1/S and early anaphase BioSystems: REACTOME 2.830E-6 2.253E-5 1.279E-4 4.613E-4 3 83
21 83064 TGF-beta signaling pathway BioSystems: KEGG 2.934E-6 2.253E-5 1.279E-4 4.783E-4 3 84
22 1269596 Degradation of beta-catenin by the destruction complex BioSystems: REACTOME 3.041E-6 2.253E-5 1.279E-4 4.957E-4 3 85
23 1269838 APC/C-mediated degradation of cell cycle proteins BioSystems: REACTOME 3.495E-6 2.374E-5 1.347E-4 5.697E-4 3 89
24 1269837 Regulation of mitotic cell cycle BioSystems: REACTOME 3.495E-6 2.374E-5 1.347E-4 5.697E-4 3 89
25 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 3.998E-6 2.606E-5 1.479E-4 6.516E-4 4 376
26 1269636 Hedgehog 'off' state BioSystems: REACTOME 5.595E-6 3.501E-5 1.987E-4 9.119E-4 3 104
27 M6031 E2F1 Destruction Pathway MSigDB C2 BIOCARTA (v6.0) 5.799E-6 3.501E-5 1.987E-4 9.453E-4 2 10
28 PW:0000435 neddylation Pathway Ontology 7.087E-6 3.904E-5 2.215E-4 1.155E-3 2 11
29 PW:0000415 proteasome degradation involving cullin-dependent ubiquitin ligases Pathway Ontology 7.087E-6 3.904E-5 2.215E-4 1.155E-3 2 11
30 1269530 Signaling by NOTCH BioSystems: REACTOME 7.185E-6 3.904E-5 2.215E-4 1.171E-3 3 113
31 1269768 G1/S Transition BioSystems: REACTOME 8.829E-6 4.642E-5 2.634E-4 1.439E-3 3 121
32 83054 Cell cycle BioSystems: KEGG 9.504E-6 4.841E-5 2.747E-4 1.549E-3 3 124
33 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 1.283E-5 6.336E-5 3.595E-4 2.091E-3 3 137
34 1269633 Signaling by Hedgehog BioSystems: REACTOME 1.399E-5 6.705E-5 3.805E-4 2.280E-3 3 141
35 83061 Wnt signaling pathway BioSystems: KEGG 1.459E-5 6.795E-5 3.856E-4 2.378E-3 3 143
36 1269764 Mitotic G1-G1/S phases BioSystems: REACTOME 1.521E-5 6.806E-5 3.862E-4 2.480E-3 3 145
37 1309122 MAP3K8 (TPL2)-dependent MAPK1/3 activation BioSystems: REACTOME 1.545E-5 6.806E-5 3.862E-4 2.518E-3 2 16
38 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 2.283E-5 9.792E-5 5.556E-4 3.721E-3 3 166
39 1269799 G2/M Transition BioSystems: REACTOME 3.108E-5 1.299E-4 7.369E-4 5.065E-3 3 184
40 1269797 Mitotic G2-G2/M phases BioSystems: REACTOME 3.210E-5 1.308E-4 7.421E-4 5.232E-3 3 186
41 138032 Canonical Wnt signaling pathway BioSystems: Pathway Interaction Database 5.972E-5 2.374E-4 1.347E-3 9.735E-3 2 31
42 1269767 Cyclin D associated events in G1 BioSystems: REACTOME 9.505E-5 3.603E-4 2.044E-3 1.549E-2 2 39
43 1269766 G1 Phase BioSystems: REACTOME 9.505E-5 3.603E-4 2.044E-3 1.549E-2 2 39
44 1269320 Interleukin-1 signaling BioSystems: REACTOME 1.326E-4 4.913E-4 2.788E-3 2.162E-2 2 46
45 1269594 Signaling by Wnt BioSystems: REACTOME 1.938E-4 7.020E-4 3.983E-3 3.159E-2 3 340
46 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 2.114E-4 7.491E-4 4.250E-3 3.446E-2 2 58
47 1269331 NIK-->noncanonical NF-kB signaling BioSystems: REACTOME 2.417E-4 8.232E-4 4.671E-3 3.939E-2 2 62
48 1269306 Dectin-1 mediated noncanonical NF-kB signaling BioSystems: REACTOME 2.496E-4 8.232E-4 4.671E-3 4.068E-2 2 63
49 1269770 SCF(Skp2)-mediated degradation of p27/p21 BioSystems: REACTOME 2.496E-4 8.232E-4 4.671E-3 4.068E-2 2 63
50 1268855 Diseases of signal transduction BioSystems: REACTOME 2.551E-4 8.232E-4 4.671E-3 4.158E-2 3 373
Show 45 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 985 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11717410 Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Pubmed 5.640E-17 2.778E-14 2.075E-13 5.556E-14 4 4
2 26753747 FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy. Pubmed 5.640E-17 2.778E-14 2.075E-13 5.556E-14 4 4
3 15531760 Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase. Pubmed 8.460E-16 2.083E-13 1.556E-12 8.333E-13 4 6
4 16714087 FBXO25, an F-box protein homologue of atrogin-1, is not induced in atrophying muscle. Pubmed 8.460E-16 2.083E-13 1.556E-12 8.333E-13 4 6
5 29103612 Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Pubmed 9.558E-15 1.883E-12 1.407E-11 9.414E-12 5 62
6 16123585 Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Pubmed 1.077E-12 1.516E-10 1.132E-9 1.061E-9 3 3
7 10648623 The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Pubmed 1.077E-12 1.516E-10 1.132E-9 1.061E-9 3 3
8 27697867 Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex. Pubmed 4.308E-12 3.536E-10 2.642E-9 4.243E-9 3 4
9 21205095 Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Pubmed 4.308E-12 3.536E-10 2.642E-9 4.243E-9 3 4
10 15118074 SCFhFBH1 can act as helicase and E3 ubiquitin ligase. Pubmed 4.308E-12 3.536E-10 2.642E-9 4.243E-9 3 4
11 16357137 FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Pubmed 4.308E-12 3.536E-10 2.642E-9 4.243E-9 3 4
12 11956208 The novel human DNA helicase hFBH1 is an F-box protein. Pubmed 4.308E-12 3.536E-10 2.642E-9 4.243E-9 3 4
13 15452136 Molecular and biochemical characterization of the Skp2-Cks1 binding interface. Pubmed 1.077E-11 6.240E-10 4.662E-9 1.061E-8 3 5
14 28522751 Targeting FBW7 as a Strategy to Overcome Resistance to Targeted Therapy in Non-Small Cell Lung Cancer. Pubmed 1.077E-11 6.240E-10 4.662E-9 1.061E-8 3 5
15 19509332 JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Pubmed 1.077E-11 6.240E-10 4.662E-9 1.061E-8 3 5
16 18660753 A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation. Pubmed 1.077E-11 6.240E-10 4.662E-9 1.061E-8 3 5
17 27568981 FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition. Pubmed 1.077E-11 6.240E-10 4.662E-9 1.061E-8 3 5
18 16009132 NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
19 26540345 Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
20 29149593 NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
21 19933270 Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
22 15103331 Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
23 28152074 Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκÎ? signaling by stabilizing IκBα. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
24 19762597 An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
25 11483504 NEDD8 recruits E2-ubiquitin to SCF E3 ligase. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
26 11961546 Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
27 12840033 The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
28 24318128 SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
29 11359933 Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
30 26725323 KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Pubmed 2.154E-11 7.072E-10 5.283E-9 2.122E-8 3 6
31 21169563 The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
32 24157836 Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
33 25585578 FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
34 10230406 Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
35 22113614 FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
36 11027288 The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
37 25654763 F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
38 12904573 Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
39 17098746 FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
40 11565034 Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
41 18809579 PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
42 12140560 E3 ubiquitin ligase that recognizes sugar chains. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
43 24657926 SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Pubmed 3.769E-11 8.634E-10 6.450E-9 3.713E-8 3 7
44 18203720 Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
45 16759355 Modification of Cul1 regulates its association with proteasomal subunits. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
46 20832730 Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
47 12504026 CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
48 18239684 Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
49 23770852 ERα, SKP2 and E2F-1 form a feed forward loop driving late ERα targets and G1 cell cycle progression. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
50 23086937 The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. Pubmed 6.030E-11 1.061E-9 7.924E-9 5.940E-8 3 8
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 1007 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SKP1 SKP1 interactions 7.379E-10 7.431E-7 5.567E-6 7.431E-7 5 266
2 int:FBXO27 FBXO27 interactions 3.934E-9 1.219E-6 9.130E-6 3.961E-6 3 14
3 int:FBXO42 FBXO42 interactions 4.916E-9 1.219E-6 9.130E-6 4.951E-6 3 15
4 int:FBXO44 FBXO44 interactions 6.051E-9 1.219E-6 9.130E-6 6.093E-6 3 16
5 int:MTSS1 MTSS1 interactions 6.051E-9 1.219E-6 9.130E-6 6.093E-6 3 16
6 int:CCNF CCNF interactions 1.047E-8 1.378E-6 1.032E-5 1.054E-5 3 19
7 int:FBXO22 FBXO22 interactions 1.047E-8 1.378E-6 1.032E-5 1.054E-5 3 19
8 int:COPS4 COPS4 interactions 1.104E-8 1.378E-6 1.032E-5 1.111E-5 4 123
9 int:FBXL15 FBXL15 interactions 1.231E-8 1.378E-6 1.032E-5 1.240E-5 3 20
10 int:FBH1 FBH1 interactions 1.436E-8 1.446E-6 1.084E-5 1.446E-5 3 21
11 int:FBXW2 FBXW2 interactions 1.663E-8 1.522E-6 1.141E-5 1.675E-5 3 22
12 int:FBXO17 FBXO17 interactions 2.185E-8 1.834E-6 1.374E-5 2.201E-5 3 24
13 int:MAGEC2 MAGEC2 interactions 2.483E-8 1.923E-6 1.441E-5 2.501E-5 3 25
14 int:FBXO3 FBXO3 interactions 3.536E-8 2.425E-6 1.817E-5 3.561E-5 3 28
15 int:FBXO32 FBXO32 interactions 3.612E-8 2.425E-6 1.817E-5 3.638E-5 4 165
16 int:FBXO31 FBXO31 interactions 4.850E-8 2.970E-6 2.226E-5 4.884E-5 3 31
17 int:RBX1 RBX1 interactions 5.015E-8 2.970E-6 2.226E-5 5.050E-5 4 179
18 int:KMT5A KMT5A interactions 5.886E-8 3.232E-6 2.421E-5 5.928E-5 3 33
19 int:FBXO25 FBXO25 interactions 6.932E-8 3.232E-6 2.421E-5 6.981E-5 4 194
20 int:FBXO21 FBXO21 interactions 7.060E-8 3.232E-6 2.421E-5 7.110E-5 3 35
21 int:FBXO5 FBXO5 interactions 7.060E-8 3.232E-6 2.421E-5 7.110E-5 3 35
22 int:ZC3HC1 ZC3HC1 interactions 7.060E-8 3.232E-6 2.421E-5 7.110E-5 3 35
23 int:KLF4 KLF4 interactions 7.701E-8 3.372E-6 2.526E-5 7.755E-5 3 36
24 int:FBXL5 FBXL5 interactions 9.855E-8 4.135E-6 3.098E-5 9.924E-5 3 39
25 int:KDM2B KDM2B interactions 1.238E-7 4.985E-6 3.735E-5 1.246E-4 3 42
26 int:FBXL12 FBXL12 interactions 1.330E-7 5.152E-6 3.860E-5 1.340E-4 3 43
27 int:DAB2IP DAB2IP interactions 1.636E-7 6.102E-6 4.572E-5 1.647E-4 3 46
28 int:MYOG MYOG interactions 1.747E-7 6.284E-6 4.708E-5 1.760E-4 3 47
29 int:GHR GHR interactions 1.864E-7 6.471E-6 4.849E-5 1.877E-4 3 48
30 int:FBXO2 FBXO2 interactions 1.985E-7 6.663E-6 4.992E-5 1.999E-4 3 49
31 int:FBXW8 FBXW8 interactions 2.112E-7 6.859E-6 5.139E-5 2.126E-4 3 50
32 int:GATA2 GATA2 interactions 2.671E-7 8.406E-6 6.298E-5 2.690E-4 3 54
33 int:FBXO11 FBXO11 interactions 3.500E-7 1.068E-5 8.001E-5 3.524E-4 3 59
34 int:FBXL22 FBXL22 interactions 6.380E-7 1.890E-5 1.416E-4 6.425E-4 2 5
35 int:GPS1 GPS1 interactions 7.259E-7 2.089E-5 1.565E-4 7.310E-4 3 75
36 int:GLMN GLMN interactions 8.829E-7 2.470E-5 1.850E-4 8.891E-4 3 80
37 int:FBXW9 FBXW9 interactions 9.569E-7 2.536E-5 1.900E-4 9.636E-4 2 6
38 int:FBXO24 FBXO24 interactions 9.569E-7 2.536E-5 1.900E-4 9.636E-4 2 6
39 int:BTRC BTRC interactions 1.299E-6 3.290E-5 2.465E-4 1.309E-3 4 403
40 int:FBXL8 FBXL8 interactions 1.339E-6 3.290E-5 2.465E-4 1.349E-3 2 7
41 int:FBXL21 FBXL21 interactions 1.339E-6 3.290E-5 2.465E-4 1.349E-3 2 7
42 int:FBXW11 FBXW11 interactions 1.392E-6 3.338E-5 2.501E-4 1.402E-3 4 410
43 int:COP1 COP1 interactions 1.486E-6 3.479E-5 2.607E-4 1.496E-3 3 95
44 int:FBXO40 FBXO40 interactions 1.786E-6 3.913E-5 2.932E-4 1.798E-3 2 8
45 int:COPS3 COPS3 interactions 1.788E-6 3.913E-5 2.932E-4 1.800E-3 3 101
46 int:CDKN1B CDKN1B interactions 1.788E-6 3.913E-5 2.932E-4 1.800E-3 3 101
47 int:FBXO10 FBXO10 interactions 2.296E-6 4.816E-5 3.609E-4 2.312E-3 2 9
48 int:FBXO33 FBXO33 interactions 2.296E-6 4.816E-5 3.609E-4 2.312E-3 2 9
49 int:UBXN7 UBXN7 interactions 2.787E-6 5.452E-5 4.085E-4 2.806E-3 3 117
50 int:FBXO8 FBXO8 interactions 2.869E-6 5.452E-5 4.085E-4 2.889E-3 2 10
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q25.2 6q25.2 2.018E-3 1.009E-2 2.304E-2 1.009E-2 1 14
2 8q24.13 8q24.13 5.470E-3 1.367E-2 3.122E-2 2.735E-2 1 38
3 22q13.2 22q13.2 8.912E-3 1.400E-2 3.197E-2 4.456E-2 1 62
4 7q36.1 7q36.1 1.120E-2 1.400E-2 3.197E-2
5.601E-2
 1 78
5 5q31 5q31 1.648E-2 1.648E-2 3.763E-2
8.240E-2
 1 115

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 47 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1171 SCF complex genenames.org 9.964E-12 3.986E-11 8.303E-11 3.986E-11 3 3
2 560 F-boxes other genenames.org 4.459E-5 8.918E-5 1.858E-4 1.784E-4 2 39
3 1032 Cullins genenames.org 2.197E-3 2.929E-3 6.102E-3 8.787E-3 1 8

13: Coexpression [Display Chart] 5 input genes in category / 561 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19695104-AF1-2 Human Breast Lin09 15genes GeneSigDB 1.762E-9 9.886E-7 6.829E-6 9.886E-7 3 14
2 M5903 Genes up-regulated by activation of Notch signaling. MSigDB H: Hallmark Gene Sets (v6.0) 2.399E-8 6.728E-6 4.648E-5 1.346E-5 3 32
3 19695104-AF2 Human Breast Lin09 128genes GeneSigDB 2.528E-7 4.727E-5 3.265E-4 1.418E-4 3 69
4 19074895-Table3 Human Liver Sakai08 86genes GeneSigDB 1.232E-4 1.417E-2
9.786E-2
6.913E-2
 2 82
5 M9224 Selected genes up-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.263E-4 1.417E-2
9.786E-2
7.083E-2
 2 83
6 M3401 Genes down-regulated in comparison of control microglia cells versus those 1 h after stimulation with IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.563E-2
1.770E-1
4.060E-1
 2 199
7 M4730 Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulatd with R848 for 8 h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.563E-2
1.770E-1
4.060E-1
 2 199
8 M3378 Genes up-regulated in comparison of Th1 cells versus induced regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
9 M3811 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
10 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
11 M3441 Genes up-regulated in comparison of intrathymic T progenitor cells (ITTP) versus naive CD4 [GeneID=920] T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
12 M3388 Genes up-regulated in comparison of Th17 cells versus natural regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
13 M4465 Genes down-regulated in comparison of neutrophils versus dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
14 M3157 Genes down-regulated in comparison of T follicular helper (Tfh) cells versus Th17 cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
15 M4836 Genes up-regulated in comparison of CD8 T cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
16 M3199 Genes down-regulated in comparison of naive B cell versus pre-germinal tonsil B cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.563E-2
1.770E-1
4.100E-1
 2 200
17 19204204-SupplementaryTable7 Human Breast Parker09 306genes IntrinsicGenes HuShort GeneSigDB 1.067E-3 3.521E-2
2.433E-1
5.986E-1
 2 242
18 12890387-Table1 Human Leukemia Wang03 06genes GeneSigDB 1.296E-3 4.039E-2
2.790E-1
7.271E-1
 1 6
19 12098359-Table2 Mouse Lung not cancer Loke02 18genes NematodeInfection up GeneSigDB 1.512E-3 4.219E-2
2.914E-1
8.482E-1
 1 7
20 20203266-TableS1a Human Leukemia Falini10 400genes Top400MLD GeneSigDB 1.601E-3 4.219E-2
2.914E-1
8.981E-1
 2 297
21 14695196-Table2 Human Colon Mariadason03 420genes GeneSigDB 1.655E-3 4.219E-2
2.914E-1
9.282E-1
 2 302
22 20103679-ST3-B Human Breast Wood10 416genes GeneSigDB 1.655E-3 4.219E-2
2.914E-1
9.282E-1
 2 302
23 M2879 Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.115E-3 4.945E-2
3.416E-1
1.000E0
 2 342
24 M9183 Pre-mitotic cell cycle regulators (CDC) identified in an shRNA screen of the ubiquitin pathway components. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.375E-3 4.945E-2
3.416E-1
1.000E0
 1 11
25 M2029 Genes down-regulated in NCI-H1299 cells (large cell neuroendocrine carcinoma) stably expressing SEMA3B [GeneID=7869]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.024E-3 4.945E-2
3.416E-1
1.000E0
 2 410
26 17895889-Table1b Human Leukemia Hamamura07 17genes GeneSigDB 3.453E-3 4.945E-2
3.416E-1
1.000E0
 1 16
27 19096012-TableS2 Human Viral Chetaille09 501genes GeneSigDB 3.458E-3 4.945E-2
3.416E-1
1.000E0
 2 439
28 M1704 Genes up-regulated in mammary glands from the CITED1 [GeneID=4435] knockout mice: homozygotic vs wild type (WT) animals. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.669E-3 4.945E-2
3.416E-1
1.000E0
 1 17
29 16705683-table3 Mouse StemCell Fujino06 22genes GeneSigDB 4.100E-3 4.945E-2
3.416E-1
1.000E0
 1 19
30 M15209 Up-regulated genes from top 82 genes out of the 324-gene signature identified in the pre-neoplastic tissue adjacent to the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.945E-2
3.416E-1
1.000E0
 1 20
31 19749795-SuppTable1 Human Leukemia Ueno09 30genes HighestUpRegulation3Days GeneSigDB 4.746E-3 4.945E-2
3.416E-1
1.000E0
 1 22
32 11573962-Table3 Human Viral Sun01 27genes Cell Cycle-Related GeneSigDB 4.746E-3 4.945E-2
3.416E-1
1.000E0
 1 22
33 M1116 Genes up-regulated in MEF cells (embryonic fibroblasts) after knockout of PML [GeneID=5371] and whose promoters were bound by MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.961E-3 4.945E-2
3.416E-1
1.000E0
 1 23
34 M2104 Genes repressed in SKBR3 cells (breast cancer) by 25-hydroxyvitamin D3 [PubChem=1593]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.391E-3 4.945E-2
3.416E-1
1.000E0
 1 25
35 M10748 Genes up-regulated in bulk samples from early primary breast tumors expressing ESR1 [GeneID=2099] vs the ESR1 negative samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.822E-3 4.945E-2
3.416E-1
1.000E0
 1 27
36 M2483 Genes with known mitosis function that were down-regulated in MEF cells (embryonic fibroblast) upon knockout of LIN9 [GeneID=286826]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.037E-3 4.945E-2
3.416E-1
1.000E0
 1 28
37 16140920-Table1b Human Brain Natsume05 54genes GeneSigDB 6.252E-3 4.945E-2
3.416E-1
1.000E0
 1 29
38 M13314 Genes down-regulated in follicular thyroid carcinoma (FTC) samples that bear PAX8-PPARG [GeneID=7849;5468] fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.327E-3 4.945E-2
3.416E-1
1.000E0
 1 34
39 M13585 Genes up-regulated in EVSA-T cells (breast cancer) treated with 5 micromolar THC (delta-9-tetrahydrocannabinol) [PubChem=6610319] for 24 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.327E-3 4.945E-2
3.416E-1
1.000E0
 1 34
40 M1648 Genes most consistently regulated at 4 h by all six genotoxins tested: cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide [PubChem=2767;4156;5746;4666;3657;36462]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.541E-3 4.945E-2
3.416E-1
1.000E0
 1 35
41 15120960-Table2 Mouse Lymphoma Hu04 39genes GeneSigDB 7.756E-3 4.945E-2
3.416E-1
1.000E0
 1 36
42 M1187 Genes down-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.186E-3 4.945E-2
3.416E-1
1.000E0
 1 38
43 17906199-SuppTable1 Human Lung Hsu07 45genes GeneSigDB 8.186E-3 4.945E-2
3.416E-1
1.000E0
 1 38
44 12890387-Table2 Human Leukemia Wang03 43genes GeneSigDB 8.400E-3 4.945E-2
3.416E-1
1.000E0
 1 39
45 M16093 Cluster d7: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.615E-3 4.945E-2
3.416E-1
1.000E0
 1 40
46 M5895 Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. MSigDB H: Hallmark Gene Sets (v6.0) 9.044E-3 4.945E-2
3.416E-1
1.000E0
 1 42
47 M3782 Genes down-regulated in ST1 cells (adult T-cell leukemia, ATL) after knockdown of FRA2 [GeneID=2355] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.945E-2
3.416E-1
1.000E0
 1 43
48 17504995-TableS3 Human Lung Larsen07 54genes GeneSigDB 9.259E-3 4.945E-2
3.416E-1
1.000E0
 1 43
49 M3464 Down-regulated genes from the optimal set of 100 markers discriminating ER(-) breast cancer tumors by BRCA1 [GeneID=672] mutation status. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.945E-2
3.416E-1
1.000E0
 1 43
50 M4902 Top down-regulated genes distinguishing between follicular thyroid carcinoma (FTC) samples by the presence or absence of the PAX8-PPARG [GeneID=7849;5468] fusion protein. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.688E-3 4.945E-2
3.416E-1
1.000E0
 1 45
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 470 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 38 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 114 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 2.000E-4 2.280E-2
1.212E-1
 2.280E-2 2 325
2 hsa-miR-377-3p:TargetScan hsa-miR-377-3p TargetScan 4.222E-4 2.407E-2
1.280E-1
 4.814E-2 2 473
3 hsa-miR-5187-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.903E-2
1.544E-1
3.940E-1
 1 50
4 GTGTCAA,MIR-514:MSigDB GTGTCAA,MIR-514:MSigDB MSigDB 4.077E-3 2.903E-2
1.544E-1
4.648E-1
 1 59
5 hsa-miR-151a-5p:Functional MTI Functional MTI miRTarbase 5.456E-3 2.903E-2
1.544E-1
6.220E-1
 1 79
6 hsa-miR-151a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 5.525E-3 2.903E-2
1.544E-1
6.298E-1
 1 80
7 hsa-miR-593-5p:Functional MTI Functional MTI miRTarbase 5.525E-3 2.903E-2
1.544E-1
6.298E-1
 1 80
8 hsa-miR-379-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.801E-3 2.903E-2
1.544E-1
6.613E-1
 1 84
9 hsa-miR-541-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.869E-3 2.903E-2
1.544E-1
6.691E-1
 1 85
10 hsa-miR-450b-3p:PITA hsa-miR-450b-3p:PITA TOP PITA 5.869E-3 2.903E-2
1.544E-1
6.691E-1
 1 85
11 hsa-miR-769-3p:PITA hsa-miR-769-3p:PITA TOP PITA 5.938E-3 2.903E-2
1.544E-1
6.770E-1
 1 86
12 hsa-miR-6855-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.076E-3 2.903E-2
1.544E-1
6.927E-1
 1 88
13 hsa-miR-4513:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.076E-3 2.903E-2
1.544E-1
6.927E-1
 1 88
14 hsa-miR-493-3p:Functional MTI Functional MTI miRTarbase 6.076E-3 2.903E-2
1.544E-1
6.927E-1
 1 88
15 hsa-miR-4439:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.283E-3 2.903E-2
1.544E-1
7.162E-1
 1 91
16 hsa-miR-3136-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.283E-3 2.903E-2
1.544E-1
7.162E-1
 1 91
17 hsa-miR-379-5p:TargetScan hsa-miR-379-5p TargetScan 6.352E-3 2.903E-2
1.544E-1
7.241E-1
 1 92
18 hsa-miR-194-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.420E-3 2.903E-2
1.544E-1
7.319E-1
 1 93
19 hsa-miR-934:PITA hsa-miR-934:PITA TOP PITA 6.696E-3 2.903E-2
1.544E-1
7.633E-1
 1 97
20 hsa-miR-4662b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.833E-3 2.903E-2
1.544E-1
7.790E-1
 1 99
21 hsa-miR-4426:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.833E-3 2.903E-2
1.544E-1
7.790E-1
 1 99
22 hsa-miR-4647:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.833E-3 2.903E-2
1.544E-1
7.790E-1
 1 99
23 hsa-miR-1308:PITA hsa-miR-1308:PITA TOP PITA 7.246E-3 2.903E-2
1.544E-1
8.261E-1
 1 105
24 hsa-miR-6761-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.453E-3 2.903E-2
1.544E-1
8.496E-1
 1 108
25 hsa-miR-299-3p:PITA hsa-miR-299-3p:PITA TOP PITA 7.522E-3 2.903E-2
1.544E-1
8.575E-1
 1 109
26 hsa-miR-921:PITA hsa-miR-921:PITA TOP PITA 7.590E-3 2.903E-2
1.544E-1
8.653E-1
 1 110
27 hsa-miR-431-5p:TargetScan hsa-miR-431-5p TargetScan 7.659E-3 2.903E-2
1.544E-1
8.732E-1
 1 111
28 hsa-miR-6857-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.659E-3 2.903E-2
1.544E-1
8.732E-1
 1 111
29 hsa-miR-589:PITA hsa-miR-589:PITA TOP PITA 8.141E-3 2.903E-2
1.544E-1
9.280E-1
 1 118
30 AAAGGAT,MIR-501:MSigDB AAAGGAT,MIR-501:MSigDB MSigDB 8.141E-3 2.903E-2
1.544E-1
9.280E-1
 1 118
31 hsa-miR-1224-5p:PITA hsa-miR-1224-5p:PITA TOP PITA 8.416E-3 2.903E-2
1.544E-1
9.594E-1
 1 122
32 hsa-miR-655-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.553E-3 2.903E-2
1.544E-1
9.751E-1
 1 124
33 hsa-miR-3123:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.691E-3 2.903E-2
1.544E-1
9.907E-1
 1 126
34 hsa-miR-188-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.309E-3 2.903E-2
1.544E-1
1.000E0
 1 135
35 hsa-miR-2681-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.013E-2 2.903E-2
1.544E-1
1.000E0
 1 147
36 TAATGTG,MIR-323:MSigDB TAATGTG,MIR-323:MSigDB MSigDB 1.027E-2 2.903E-2
1.544E-1
1.000E0
 1 149
37 ACCATTT,MIR-522:MSigDB ACCATTT,MIR-522:MSigDB MSigDB 1.048E-2 2.903E-2
1.544E-1
1.000E0
 1 152
38 GTCTTCC,MIR-7:MSigDB GTCTTCC,MIR-7:MSigDB MSigDB 1.068E-2 2.903E-2
1.544E-1
1.000E0
 1 155
39 hsa-miR-1200:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.109E-2 2.903E-2
1.544E-1
1.000E0
 1 161
40 CATGTAA,MIR-496:MSigDB CATGTAA,MIR-496:MSigDB MSigDB 1.130E-2 2.903E-2
1.544E-1
1.000E0
 1 164
41 hsa-miR-1197:TargetScan hsa-miR-1197 TargetScan 1.178E-2 2.903E-2
1.544E-1
1.000E0
 1 171
42 hsa-miR-4324:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.185E-2 2.903E-2
1.544E-1
1.000E0
 1 172
43 hsa-miR-3149:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.192E-2 2.903E-2
1.544E-1
1.000E0
 1 173
44 hsa-miR-514:PITA hsa-miR-514:PITA TOP PITA 1.205E-2 2.903E-2
1.544E-1
1.000E0
 1 175
45 hsa-miR-657:PITA hsa-miR-657:PITA TOP PITA 1.205E-2 2.903E-2
1.544E-1
1.000E0
 1 175
46 hsa-miR-4735-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.240E-2 2.903E-2
1.544E-1
1.000E0
 1 180
47 TGTGTGA,MIR-377:MSigDB TGTGTGA,MIR-377:MSigDB MSigDB 1.267E-2 2.903E-2
1.544E-1
1.000E0
 1 184
48 hsa-miR-2276-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.322E-2 2.903E-2
1.544E-1
1.000E0
 1 192
49 hsa-miR-489:PITA hsa-miR-489:PITA TOP PITA 1.322E-2 2.903E-2
1.544E-1
1.000E0
 1 192
50 ATACTGT,MIR-144:MSigDB ATACTGT,MIR-144:MSigDB MSigDB 1.329E-2 2.903E-2
1.544E-1
1.000E0
 1 193
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 457 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D006902 Hydroxymercuribenzoates CTD 1.007E-10 4.602E-8 3.085E-7 4.602E-8 3 6
2 CID005311104 j I N Stitch 3.256E-9 7.441E-7 4.988E-6 1.488E-6 4 117
3 CID000444966 Cu L Stitch 5.355E-8 8.157E-6 5.468E-5 2.447E-5 3 41
4 CID000024014 CuCl2 Stitch 1.245E-7 1.422E-5 9.534E-5 5.689E-5 3 54
5 CID005327193 I-Br Stitch 2.513E-7 2.297E-5 1.540E-4 1.148E-4 3 68
6 CID006437867 D dB Stitch 3.666E-7 2.792E-5 1.872E-4 1.675E-4 3 77
7 ctd:D020280 Sertraline CTD 1.234E-6 8.058E-5 5.401E-4 5.640E-4 3 115
8 CID000105087 (+/-)-Jasmonic Acid Stitch 3.215E-6 1.836E-4 1.231E-3 1.469E-3 3 158
9 CID000017961 P-19 Stitch 4.447E-6 2.258E-4 1.514E-3 2.032E-3 3 176
10 CID006420160 2f34 Stitch 5.422E-6 2.478E-4 1.661E-3 2.478E-3 3 188
11 CID000000801 auxin Stitch 9.173E-6 3.811E-4 2.554E-3 4.192E-3 3 224
12 CID000081462 BT-B Stitch 1.171E-5 4.059E-4 2.720E-3 5.351E-3 3 243
13 CID000464976 KPC-2 Stitch 1.243E-5 4.059E-4 2.720E-3 5.682E-3 2 26
14 CID000071749 hydrotalcite Stitch 1.243E-5 4.059E-4 2.720E-3 5.682E-3 2 26
15 ctd:C121707 7,3'-dihydroxy-4'-methoxyisoflavone CTD 3.953E-5 1.204E-3 8.072E-3 1.806E-2 2 46
16 CID009868928 Z-LLnV Stitch 5.876E-5 1.678E-3 1.125E-2 2.685E-2 2 56
17 CID000060787 Ro 31-8959 Stitch 1.327E-4 3.450E-3 2.312E-2
6.064E-2
 2 84
18 CID000066393 estradiol-2,3-quinone Stitch 1.359E-4 3.450E-3 2.312E-2
6.209E-2
 2 85
19 ctd:C095716 N-acetyl-S-geranylgeranyl-cysteine CTD 2.189E-4 5.265E-3 3.529E-2
1.000E-1
 1 1
20 CID000000535 1-aminocyclopropane-1-carboxylic acid Stitch 2.445E-4 5.587E-3 3.745E-2
1.117E-1
 2 114
21 ctd:C539427 N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide CTD 6.566E-4 1.429E-2
9.578E-2
3.001E-1
 1 3
22 2002 UP Trimethobenzamide hydrochloride [554-92-7]; Up 200; 9.4uM; HL60; HG-U133A Broad Institute CMAP Up 7.349E-4 1.527E-2
1.023E-1
3.359E-1
 2 198
23 CID000135411 CD437 Stitch 7.723E-4 1.534E-2
1.029E-1
3.529E-1
 2 203
24 CID000006623 bisphenol A Stitch 9.307E-4 1.680E-2
1.126E-1
4.253E-1
 2 223
25 ctd:C099555 CD 437 CTD 9.307E-4 1.680E-2
1.126E-1
4.253E-1
 2 223
26 CID001008511 1,4-bis-(phenoxyacetyl)piperazine Stitch 9.557E-4 1.680E-2
1.126E-1
4.368E-1
 2 226
27 ctd:C084179 2-phenyl-4-oxohydroquinoline CTD 1.094E-3 1.768E-2
1.185E-1
5.000E-1
 1 5
28 ctd:C004961 beta-hydroxyisovaleric acid CTD 1.094E-3 1.768E-2
1.185E-1
5.000E-1
 1 5
29 CID000006326 vinylene Stitch 1.122E-3 1.768E-2
1.185E-1
5.126E-1
 2 245
30 ctd:C501521 Akt-I-1,2 compound CTD 1.532E-3 2.333E-2
1.564E-1
6.999E-1
 1 7
31 ctd:C017719 solanesol CTD 1.750E-3 2.580E-2
1.729E-1
7.998E-1
 1 8
32 CID004631409 AC1NDTNH Stitch 2.182E-3 3.029E-2
2.030E-1
9.973E-1
 2 343
33 ctd:C076159 2,3-dichloro-1-propanol CTD 2.187E-3 3.029E-2
2.030E-1
9.996E-1
 1 10
34 CID000003744 indole-3-propionic acid Stitch 2.843E-3 3.821E-2
2.561E-1
1.000E0
 1 13
35 ctd:D019274 Botulinum Toxins, Type A CTD 3.498E-3 4.567E-2
3.061E-1
1.000E0
 1 16
36 ctd:D020123 Sirolimus CTD 3.854E-3 4.645E-2
3.114E-1
1.000E0
 2 458
37 ctd:D002703 Chloranil CTD 3.934E-3 4.645E-2
3.114E-1
1.000E0
 1 18
38 CID000007104 B on A Stitch 3.954E-3 4.645E-2
3.114E-1
1.000E0
 2 464
39 ctd:C473711 Chir 99021 CTD 4.153E-3 4.645E-2
3.114E-1
1.000E0
 1 19
40 ctd:C032208 perillyl alcohol CTD 4.153E-3 4.645E-2
3.114E-1
1.000E0
 1 19
41 ctd:D000069439 Dasatinib CTD 4.191E-3 4.645E-2
3.114E-1
1.000E0
 2 478
42 CID000435143 NSC-364372 Stitch 4.295E-3 4.645E-2
3.114E-1
1.000E0
 2 484
43 CID000031261 acetylacetone Stitch 4.371E-3 4.645E-2
3.114E-1
1.000E0
 1 20
44 CID000008927 elaidyl alcohol Stitch 5.025E-3 4.807E-2
3.222E-1
1.000E0
 1 23
45 CID000007979 TEGDMA Stitch 5.461E-3 4.807E-2
3.222E-1
1.000E0
 1 25
46 CID009543464 P-1S Stitch 5.679E-3 4.807E-2
3.222E-1
1.000E0
 1 26
47 CID005289098 P-3A Stitch 5.897E-3 4.807E-2
3.222E-1
1.000E0
 1 27
48 CID011527397 2H1H Stitch 6.115E-3 4.807E-2
3.222E-1
1.000E0
 1 28
49 CID005288653 CID5288653 Stitch 6.115E-3 4.807E-2
3.222E-1
1.000E0
 1 28
50 CID000031216 tri-n-butylborane Stitch 6.115E-3 4.807E-2
3.222E-1
1.000E0
 1 28
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 38 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0038325 Stevens-Johnson Syndrome DisGeNET Curated 6.526E-5 2.480E-3 1.048E-2 2.480E-3 2 42
2 C0024408 Machado-Joseph Disease DisGeNET Curated 2.039E-4 3.874E-3 1.638E-2 7.748E-3 2 74
3 C1841984 GLOMUVENOUS MALFORMATIONS DisGeNET Curated 2.158E-3 2.050E-2
8.669E-2
8.201E-2
 1 7
4 C0264122 Atrophy, Disuse DisGeNET BeFree 2.158E-3 2.050E-2
8.669E-2
8.201E-2
 1 7
5 C0040425 Tonsillitis DisGeNET BeFree 3.698E-3 2.210E-2
9.345E-2
1.405E-1
 1 12
6 C0026846 Muscular Atrophy DisGeNET Curated 4.313E-3 2.210E-2
9.345E-2
1.639E-1
 1 14
7 C0042373 Vascular Diseases DisGeNET Curated 4.915E-3 2.210E-2
9.345E-2
1.868E-1
 2 368
8 C0013589 Ectromelia DisGeNET BeFree 4.928E-3 2.210E-2
9.345E-2
1.872E-1
 1 16
9 C0751560 Malignant neoplasm tonsil DisGeNET BeFree 5.235E-3 2.210E-2
9.345E-2
1.989E-1
 1 17
10 C0558355 Tonsillar Carcinoma DisGeNET BeFree 5.849E-3 2.223E-2
9.398E-2
2.223E-1
 1 19
11 C0872084 Sarcopenia DisGeNET Curated 8.304E-3 2.869E-2
1.213E-1
3.156E-1
 1 27
12 C0410158 Muscle damage DisGeNET BeFree 1.350E-2 4.276E-2
1.808E-1
5.132E-1
 1 44
Show 7 more annotations