1: GO: Molecular Function [Display Chart]
13 input genes in category / 19 annotations before applied cutoff / 18661 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
GO:0035174
|
histone serine kinase activity
|
|
1.251E-5
|
2.378E-4
|
8.436E-4
|
2.378E-4
|
2
|
8
|
|
2
|
GO:0035173
|
histone kinase activity
|
|
7.610E-5
|
7.229E-4
|
2.565E-3
|
1.446E-3
|
2
|
19
|
|
3
|
GO:0004674
|
protein serine/threonine kinase activity
|
|
2.041E-4
|
1.293E-3
|
4.587E-3
|
3.878E-3
|
4
|
452
|
|
4
|
GO:0004712
|
protein serine/threonine/tyrosine kinase activity
|
|
4.963E-4
|
2.357E-3
|
8.363E-3
|
9.430E-3
|
2
|
48
|
|
5
|
GO:0010997
|
anaphase-promoting complex binding
|
|
4.173E-3
|
1.541E-2
|
5.468E-2
|
7.929E-2
|
1
|
6
|
|
6
|
GO:0019237
|
centromeric DNA binding
|
|
4.867E-3
|
1.541E-2
|
5.468E-2
|
9.247E-2
|
1
|
7
|
|
7
|
GO:0097027
|
ubiquitin-protein transferase activator activity
|
|
6.946E-3
|
1.885E-2
|
6.689E-2
|
1.320E-1
|
1
|
10
|
|
8
|
GO:0055106
|
ubiquitin-protein transferase regulator activity
|
|
1.040E-2
|
2.342E-2
|
8.308E-2
|
1.977E-1
|
1
|
15
|
|
9
|
GO:0055103
|
ligase regulator activity
|
|
1.109E-2
|
2.342E-2
|
8.308E-2
|
2.108E-1
|
1
|
16
|
Show 4 more annotations
|
2: GO: Biological Process [Display Chart]
13 input genes in category / 344 annotations before applied cutoff / 18623 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
GO:0007062
|
sister chromatid cohesion
|
|
7.349E-23
|
2.528E-20
|
1.623E-19
|
2.528E-20
|
11
|
127
|
|
2
|
GO:0000819
|
sister chromatid segregation
|
|
4.784E-20
|
8.228E-18
|
5.282E-17
|
1.646E-17
|
11
|
225
|
|
3
|
GO:0098813
|
nuclear chromosome segregation
|
|
6.242E-19
|
6.600E-17
|
4.237E-16
|
2.147E-16
|
11
|
283
|
|
4
|
GO:0031577
|
spindle checkpoint
|
|
7.675E-19
|
6.600E-17
|
4.237E-16
|
2.640E-16
|
8
|
45
|
|
5
|
GO:0007059
|
chromosome segregation
|
|
3.831E-18
|
2.636E-16
|
1.692E-15
|
1.318E-15
|
11
|
333
|
|
6
|
GO:0000075
|
cell cycle checkpoint
|
|
4.581E-15
|
2.627E-13
|
1.686E-12
|
1.576E-12
|
9
|
234
|
|
7
|
GO:0000070
|
mitotic sister chromatid segregation
|
|
8.198E-15
|
4.029E-13
|
2.586E-12
|
2.820E-12
|
8
|
136
|
|
8
|
GO:0071173
|
spindle assembly checkpoint
|
|
2.664E-14
|
1.145E-12
|
7.353E-12
|
9.163E-12
|
6
|
32
|
|
9
|
GO:0051302
|
regulation of cell division
|
|
3.324E-14
|
1.270E-12
|
8.155E-12
|
1.143E-11
|
9
|
291
|
|
10
|
GO:0051983
|
regulation of chromosome segregation
|
|
6.367E-14
|
2.190E-12
|
1.406E-11
|
2.190E-11
|
7
|
87
|
|
11
|
GO:0051783
|
regulation of nuclear division
|
|
7.020E-14
|
2.195E-12
|
1.409E-11
|
2.415E-11
|
8
|
177
|
|
12
|
GO:0033046
|
negative regulation of sister chromatid segregation
|
|
1.318E-13
|
3.778E-12
|
2.425E-11
|
4.533E-11
|
6
|
41
|
|
13
|
GO:0051985
|
negative regulation of chromosome segregation
|
|
1.786E-13
|
4.725E-12
|
3.033E-11
|
6.143E-11
|
6
|
43
|
|
14
|
GO:0030071
|
regulation of mitotic metaphase/anaphase transition
|
|
4.088E-13
|
1.004E-11
|
6.448E-11
|
1.406E-10
|
6
|
49
|
|
15
|
GO:1902099
|
regulation of metaphase/anaphase transition of cell cycle
|
|
4.644E-13
|
1.065E-11
|
6.834E-11
|
1.597E-10
|
6
|
50
|
|
16
|
GO:0043161
|
proteasome-mediated ubiquitin-dependent protein catabolic process
|
|
5.030E-13
|
1.065E-11
|
6.834E-11
|
1.730E-10
|
9
|
393
|
|
17
|
GO:0007091
|
metaphase/anaphase transition of mitotic cell cycle
|
|
5.261E-13
|
1.065E-11
|
6.834E-11
|
1.810E-10
|
6
|
51
|
|
18
|
GO:0010965
|
regulation of mitotic sister chromatid separation
|
|
5.946E-13
|
1.076E-11
|
6.910E-11
|
2.045E-10
|
6
|
52
|
|
19
|
GO:0044784
|
metaphase/anaphase transition of cell cycle
|
|
5.946E-13
|
1.076E-11
|
6.910E-11
|
2.045E-10
|
6
|
52
|
|
20
|
GO:0051306
|
mitotic sister chromatid separation
|
|
7.538E-13
|
1.297E-11
|
8.323E-11
|
2.593E-10
|
6
|
54
|
|
21
|
GO:0010948
|
negative regulation of cell cycle process
|
|
8.244E-13
|
1.350E-11
|
8.669E-11
|
2.836E-10
|
8
|
240
|
|
22
|
GO:0010498
|
proteasomal protein catabolic process
|
|
9.554E-13
|
1.494E-11
|
9.590E-11
|
3.287E-10
|
9
|
422
|
|
23
|
GO:0033047
|
regulation of mitotic sister chromatid segregation
|
|
1.180E-12
|
1.765E-11
|
1.133E-10
|
4.058E-10
|
6
|
58
|
|
24
|
GO:1903050
|
regulation of proteolysis involved in cellular protein catabolic process
|
|
1.945E-12
|
2.788E-11
|
1.790E-10
|
6.691E-10
|
8
|
267
|
|
25
|
GO:0007088
|
regulation of mitotic nuclear division
|
|
3.002E-12
|
4.131E-11
|
2.652E-10
|
1.033E-9
|
7
|
149
|
|
26
|
GO:0033045
|
regulation of sister chromatid segregation
|
|
3.180E-12
|
4.175E-11
|
2.680E-10
|
1.094E-9
|
6
|
68
|
|
27
|
GO:0045786
|
negative regulation of cell cycle
|
|
3.277E-12
|
4.175E-11
|
2.680E-10
|
1.127E-9
|
9
|
484
|
|
28
|
GO:1903362
|
regulation of cellular protein catabolic process
|
|
3.476E-12
|
4.270E-11
|
2.741E-10
|
1.196E-9
|
8
|
287
|
|
29
|
GO:0032434
|
regulation of proteasomal ubiquitin-dependent protein catabolic process
|
|
3.795E-12
|
4.501E-11
|
2.889E-10
|
1.305E-9
|
7
|
154
|
|
30
|
GO:0051304
|
chromosome separation
|
|
4.157E-12
|
4.767E-11
|
3.060E-10
|
1.430E-9
|
6
|
71
|
|
31
|
GO:0007093
|
mitotic cell cycle checkpoint
|
|
5.434E-12
|
6.030E-11
|
3.871E-10
|
1.869E-9
|
7
|
162
|
|
32
|
GO:0051782
|
negative regulation of cell division
|
|
5.837E-12
|
6.275E-11
|
4.028E-10
|
2.008E-9
|
6
|
75
|
|
33
|
GO:0031145
|
anaphase-promoting complex-dependent catabolic process
|
|
6.869E-12
|
7.160E-11
|
4.596E-10
|
2.363E-9
|
6
|
77
|
|
34
|
GO:1901990
|
regulation of mitotic cell cycle phase transition
|
|
7.913E-12
|
8.006E-11
|
5.139E-10
|
2.722E-9
|
8
|
318
|
|
35
|
GO:0007094
|
mitotic spindle assembly checkpoint
|
|
1.161E-11
|
1.141E-10
|
7.327E-10
|
3.995E-9
|
5
|
31
|
|
36
|
GO:1901987
|
regulation of cell cycle phase transition
|
|
1.290E-11
|
1.232E-10
|
7.910E-10
|
4.436E-9
|
8
|
338
|
|
37
|
GO:0061136
|
regulation of proteasomal protein catabolic process
|
|
1.617E-11
|
1.503E-10
|
9.650E-10
|
5.562E-9
|
7
|
189
|
|
38
|
GO:0045841
|
negative regulation of mitotic metaphase/anaphase transition
|
|
2.215E-11
|
1.954E-10
|
1.254E-9
|
7.621E-9
|
5
|
35
|
|
39
|
GO:0071174
|
mitotic spindle checkpoint
|
|
2.215E-11
|
1.954E-10
|
1.254E-9
|
7.621E-9
|
5
|
35
|
|
40
|
GO:1902100
|
negative regulation of metaphase/anaphase transition of cell cycle
|
|
2.572E-11
|
2.158E-10
|
1.385E-9
|
8.847E-9
|
5
|
36
|
|
41
|
GO:2000816
|
negative regulation of mitotic sister chromatid separation
|
|
2.572E-11
|
2.158E-10
|
1.385E-9
|
8.847E-9
|
5
|
36
|
|
42
|
GO:0033048
|
negative regulation of mitotic sister chromatid segregation
|
|
3.422E-11
|
2.803E-10
|
1.799E-9
|
1.177E-8
|
5
|
38
|
|
43
|
GO:0034501
|
protein localization to kinetochore
|
|
4.697E-11
|
3.757E-10
|
2.412E-9
|
1.616E-8
|
4
|
11
|
|
44
|
GO:0045930
|
negative regulation of mitotic cell cycle
|
|
5.523E-11
|
4.318E-10
|
2.772E-9
|
1.900E-8
|
7
|
225
|
|
45
|
GO:0042176
|
regulation of protein catabolic process
|
|
6.513E-11
|
4.979E-10
|
3.196E-9
|
2.241E-8
|
8
|
414
|
|
46
|
GO:2001251
|
negative regulation of chromosome organization
|
|
8.944E-11
|
6.689E-10
|
4.294E-9
|
3.077E-8
|
6
|
117
|
|
47
|
GO:0071459
|
protein localization to chromosome, centromeric region
|
|
1.017E-10
|
7.442E-10
|
4.778E-9
|
3.498E-8
|
4
|
13
|
|
48
|
GO:0045839
|
negative regulation of mitotic nuclear division
|
|
1.295E-10
|
9.280E-10
|
5.957E-9
|
4.454E-8
|
5
|
49
|
|
49
|
GO:0051784
|
negative regulation of nuclear division
|
|
4.022E-10
|
2.824E-9
|
1.813E-8
|
1.384E-7
|
5
|
61
|
|
50
|
GO:0033044
|
regulation of chromosome organization
|
|
4.245E-10
|
2.920E-9
|
1.875E-8
|
1.460E-7
|
7
|
301
|
Show 45 more annotations
|
3: GO: Cellular Component [Display Chart]
13 input genes in category / 50 annotations before applied cutoff / 19061 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
GO:0000779
|
condensed chromosome, centromeric region
|
|
4.676E-21
|
2.338E-19
|
1.052E-18
|
2.338E-19
|
10
|
105
|
|
2
|
GO:0000775
|
chromosome, centromeric region
|
|
1.619E-18
|
4.047E-17
|
1.821E-16
|
8.095E-17
|
10
|
185
|
|
3
|
GO:0000793
|
condensed chromosome
|
|
5.355E-18
|
8.925E-17
|
4.016E-16
|
2.678E-16
|
10
|
208
|
|
4
|
GO:0000776
|
kinetochore
|
|
1.087E-17
|
1.358E-16
|
6.111E-16
|
5.433E-16
|
9
|
124
|
|
5
|
GO:0000777
|
condensed chromosome kinetochore
|
|
3.552E-16
|
3.552E-15
|
1.598E-14
|
1.776E-14
|
8
|
95
|
|
6
|
GO:0098687
|
chromosomal region
|
|
8.775E-16
|
7.312E-15
|
3.290E-14
|
4.387E-14
|
10
|
344
|
|
7
|
GO:0005819
|
spindle
|
|
4.244E-10
|
3.031E-9
|
1.364E-8
|
2.122E-8
|
7
|
308
|
|
8
|
GO:0000780
|
condensed nuclear chromosome, centromeric region
|
|
7.733E-10
|
4.833E-9
|
2.175E-8
|
3.866E-8
|
4
|
21
|
|
9
|
GO:0000922
|
spindle pole
|
|
1.887E-8
|
1.048E-7
|
4.717E-7
|
9.436E-7
|
5
|
133
|
|
10
|
GO:0072686
|
mitotic spindle
|
|
8.077E-8
|
4.038E-7
|
1.817E-6
|
4.038E-6
|
4
|
64
|
|
11
|
GO:0000794
|
condensed nuclear chromosome
|
|
4.350E-7
|
1.977E-6
|
8.896E-6
|
2.175E-5
|
4
|
97
|
|
12
|
GO:0051233
|
spindle midzone
|
|
9.955E-7
|
4.148E-6
|
1.866E-5
|
4.978E-5
|
3
|
30
|
|
13
|
GO:0032133
|
chromosome passenger complex
|
|
4.289E-6
|
1.650E-5
|
7.422E-5
|
2.144E-4
|
2
|
5
|
|
14
|
GO:0005876
|
spindle microtubule
|
|
8.292E-6
|
2.962E-5
|
1.332E-4
|
4.146E-4
|
3
|
60
|
|
15
|
GO:0000778
|
condensed nuclear chromosome kinetochore
|
|
1.926E-5
|
6.421E-5
|
2.889E-4
|
9.632E-4
|
2
|
10
|
|
16
|
GO:0031616
|
spindle pole centrosome
|
|
3.335E-5
|
9.809E-5
|
4.413E-4
|
1.668E-3
|
2
|
13
|
|
17
|
GO:0000940
|
condensed chromosome outer kinetochore
|
|
3.335E-5
|
9.809E-5
|
4.413E-4
|
1.668E-3
|
2
|
13
|
|
18
|
GO:0005680
|
anaphase-promoting complex
|
|
9.843E-5
|
2.734E-4
|
1.230E-3
|
4.921E-3
|
2
|
22
|
|
19
|
GO:0000152
|
nuclear ubiquitin ligase complex
|
|
3.641E-4
|
9.581E-4
|
4.310E-3
|
1.820E-2
|
2
|
42
|
|
20
|
GO:0033597
|
mitotic checkpoint complex
|
|
6.820E-4
|
1.624E-3
|
7.306E-3
|
3.410E-2
|
1
|
1
|
|
21
|
GO:1990298
|
bub1-bub3 complex
|
|
6.820E-4
|
1.624E-3
|
7.306E-3
|
3.410E-2
|
1
|
1
|
|
22
|
GO:1990423
|
RZZ complex
|
|
2.045E-3
|
4.260E-3
|
1.917E-2
|
1.022E-1
|
1
|
3
|
|
23
|
GO:0070939
|
Dsl1/NZR complex
|
|
2.045E-3
|
4.260E-3
|
1.917E-2
|
1.022E-1
|
1
|
3
|
|
24
|
GO:0042585
|
germinal vesicle
|
|
2.045E-3
|
4.260E-3
|
1.917E-2
|
1.022E-1
|
1
|
3
|
|
25
|
GO:0005814
|
centriole
|
|
2.253E-3
|
4.507E-3
|
2.028E-2
|
1.127E-1
|
2
|
105
|
|
26
|
GO:0005874
|
microtubule
|
|
2.683E-3
|
5.047E-3
|
2.271E-2
|
1.342E-1
|
3
|
426
|
|
27
|
GO:0000942
|
condensed nuclear chromosome outer kinetochore
|
|
2.726E-3
|
5.047E-3
|
2.271E-2
|
1.363E-1
|
1
|
4
|
|
28
|
GO:0000444
|
MIS12/MIND type complex
|
|
3.406E-3
|
6.082E-3
|
2.736E-2
|
1.703E-1
|
1
|
5
|
|
29
|
GO:0030496
|
midbody
|
|
3.798E-3
|
6.548E-3
|
2.946E-2
|
1.899E-1
|
2
|
137
|
|
30
|
GO:0001674
|
female germ cell nucleus
|
|
4.086E-3
|
6.590E-3
|
2.965E-2
|
2.043E-1
|
1
|
6
|
|
31
|
GO:0005828
|
kinetochore microtubule
|
|
4.086E-3
|
6.590E-3
|
2.965E-2
|
2.043E-1
|
1
|
6
|
|
32
|
GO:0044450
|
microtubule organizing center part
|
|
4.358E-3
|
6.809E-3
|
3.064E-2
|
2.179E-1
|
2
|
147
|
|
33
|
GO:0031461
|
cullin-RING ubiquitin ligase complex
|
|
4.771E-3
|
7.195E-3
|
3.237E-2
|
2.386E-1
|
2
|
154
|
|
34
|
GO:0005875
|
microtubule associated complex
|
|
4.893E-3
|
7.195E-3
|
3.237E-2
|
2.446E-1
|
2
|
156
|
|
35
|
GO:0043203
|
axon hillock
|
|
5.444E-3
|
7.777E-3
|
3.499E-2
|
2.722E-1
|
1
|
8
|
|
36
|
GO:0072687
|
meiotic spindle
|
|
6.123E-3
|
8.504E-3
|
3.826E-2
|
3.061E-1
|
1
|
9
|
|
37
|
GO:0097431
|
mitotic spindle pole
|
|
9.509E-3
|
1.285E-2
|
5.782E-2
|
4.755E-1
|
1
|
14
|
|
38
|
GO:0010369
|
chromocenter
|
|
1.154E-2
|
1.518E-2
|
6.829E-2
|
5.768E-1
|
1
|
17
|
|
39
|
GO:0045120
|
pronucleus
|
|
1.423E-2
|
1.808E-2
|
8.135E-2
|
7.116E-1
|
1
|
21
|
|
40
|
GO:0000151
|
ubiquitin ligase complex
|
|
1.447E-2
|
1.808E-2
|
8.135E-2
|
7.233E-1
|
2
|
274
|
|
41
|
GO:0034451
|
centriolar satellite
|
|
1.692E-2
|
2.064E-2
|
9.285E-2
|
8.461E-1
|
1
|
25
|
|
42
|
GO:0043073
|
germ cell nucleus
|
|
1.826E-2
|
2.174E-2
|
9.783E-2
|
9.132E-1
|
1
|
27
|
|
43
|
GO:0045171
|
intercellular bridge
|
|
2.961E-2
|
3.443E-2
|
1.549E-1
|
1.000E0
|
1
|
44
|
Show 38 more annotations
|
4: Human Phenotype [Display Chart]
6 input genes in category / 284 annotations before applied cutoff / 4707 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
HP:0006849
|
Hypodysplasia of the corpus callosum
|
|
1.150E-8
|
3.267E-6
|
2.035E-5
|
3.267E-6
|
3
|
5
|
|
2
|
HP:0200024
|
Premature chromatid separation
|
|
4.022E-8
|
5.712E-6
|
3.557E-5
|
1.142E-5
|
3
|
7
|
|
3
|
HP:0000879
|
Short sternum
|
|
7.777E-7
|
7.362E-5
|
4.585E-4
|
2.209E-4
|
3
|
17
|
|
4
|
HP:0002247
|
Duodenal atresia
|
|
2.307E-6
|
1.092E-4
|
6.801E-4
|
6.552E-4
|
3
|
24
|
|
5
|
HP:0000207
|
Triangular mouth
|
|
2.307E-6
|
1.092E-4
|
6.801E-4
|
6.552E-4
|
3
|
24
|
|
6
|
HP:0006714
|
Aplasia/Hypoplasia of the sternum
|
|
2.307E-6
|
1.092E-4
|
6.801E-4
|
6.552E-4
|
3
|
24
|
|
7
|
HP:0012126
|
Stomach cancer
|
|
2.961E-6
|
1.201E-4
|
7.481E-4
|
8.409E-4
|
3
|
26
|
|
8
|
HP:0000340
|
Sloping forehead
|
|
3.797E-6
|
1.348E-4
|
8.395E-4
|
1.078E-3
|
4
|
108
|
|
9
|
HP:0100650
|
Vaginal neoplasm
|
|
4.615E-6
|
1.456E-4
|
9.069E-4
|
1.311E-3
|
3
|
30
|
|
10
|
HP:0100834
|
Neoplasm of the large intestine
|
|
7.275E-6
|
2.066E-4
|
1.287E-3
|
2.066E-3
|
4
|
127
|
|
11
|
HP:0010880
|
Increased nuchal translucency
|
|
8.092E-6
|
2.083E-4
|
1.297E-3
|
2.298E-3
|
3
|
36
|
|
12
|
HP:0000048
|
Bifid scrotum
|
|
8.802E-6
|
2.083E-4
|
1.297E-3
|
2.500E-3
|
3
|
37
|
|
13
|
HP:0001682
|
Subvalvular aortic stenosis
|
|
1.205E-5
|
2.633E-4
|
1.640E-3
|
3.423E-3
|
3
|
41
|
|
14
|
HP:0006716
|
Hereditary nonpolyposis colorectal carcinoma
|
|
1.495E-5
|
2.675E-4
|
1.666E-3
|
4.246E-3
|
3
|
44
|
|
15
|
HP:0011103
|
Abnormal left ventricular outflow tract morphology
|
|
1.495E-5
|
2.675E-4
|
1.666E-3
|
4.246E-3
|
3
|
44
|
|
16
|
HP:0002891
|
Uterine leiomyosarcoma
|
|
1.601E-5
|
2.675E-4
|
1.666E-3
|
4.548E-3
|
3
|
45
|
|
17
|
HP:0011100
|
Intestinal atresia
|
|
1.601E-5
|
2.675E-4
|
1.666E-3
|
4.548E-3
|
3
|
45
|
|
18
|
HP:0006753
|
Neoplasm of the stomach
|
|
1.830E-5
|
2.887E-4
|
1.798E-3
|
5.197E-3
|
4
|
160
|
|
19
|
HP:0002246
|
Abnormality of the duodenum
|
|
2.206E-5
|
3.298E-4
|
2.054E-3
|
6.266E-3
|
3
|
50
|
|
20
|
HP:0000142
|
Abnormal vagina morphology
|
|
2.329E-5
|
3.300E-4
|
2.055E-3
|
6.614E-3
|
4
|
170
|
|
21
|
HP:0000003
|
Multicystic kidney dysplasia
|
|
2.440E-5
|
3.300E-4
|
2.055E-3
|
6.929E-3
|
4
|
172
|
|
22
|
HP:0000582
|
Upslanted palpebral fissure
|
|
2.923E-5
|
3.638E-4
|
2.266E-3
|
8.301E-3
|
4
|
180
|
|
23
|
HP:0006740
|
Transitional cell carcinoma of the bladder
|
|
2.946E-5
|
3.638E-4
|
2.266E-3
|
8.367E-3
|
3
|
55
|
|
24
|
HP:0007565
|
Multiple cafe-au-lait spots
|
|
3.111E-5
|
3.682E-4
|
2.293E-3
|
8.837E-3
|
3
|
56
|
|
25
|
HP:0006749
|
Malignant gastrointestinal tract tumors
|
|
3.460E-5
|
3.754E-4
|
2.338E-3
|
9.827E-3
|
3
|
58
|
|
26
|
HP:0002672
|
Gastrointestinal carcinoma
|
|
3.460E-5
|
3.754E-4
|
2.338E-3
|
9.827E-3
|
3
|
58
|
|
27
|
HP:0200006
|
Slanting of the palpebral fissure
|
|
3.743E-5
|
3.754E-4
|
2.338E-3
|
1.063E-2
|
5
|
437
|
|
28
|
HP:0000368
|
Low-set, posteriorly rotated ears
|
|
3.776E-5
|
3.754E-4
|
2.338E-3
|
1.072E-2
|
4
|
192
|
|
29
|
HP:0001360
|
Holoprosencephaly
|
|
3.834E-5
|
3.754E-4
|
2.338E-3
|
1.089E-2
|
3
|
60
|
|
30
|
HP:0005933
|
Kidney cancer
|
|
5.086E-5
|
4.815E-4
|
2.999E-3
|
1.444E-2
|
4
|
207
|
|
31
|
HP:0200008
|
Intestinal polyposis
|
|
5.593E-5
|
5.124E-4
|
3.191E-3
|
1.588E-2
|
3
|
68
|
|
32
|
HP:0009726
|
Renal neoplasm
|
|
6.242E-5
|
5.462E-4
|
3.402E-3
|
1.773E-2
|
4
|
218
|
|
33
|
HP:0000054
|
Micropenis
|
|
6.588E-5
|
5.462E-4
|
3.402E-3
|
1.871E-2
|
4
|
221
|
|
34
|
HP:0011344
|
Severe global developmental delay
|
|
6.643E-5
|
5.462E-4
|
3.402E-3
|
1.887E-2
|
3
|
72
|
|
35
|
HP:0005266
|
Intestinal polyp
|
|
6.924E-5
|
5.462E-4
|
3.402E-3
|
1.966E-2
|
3
|
73
|
|
36
|
HP:0002589
|
Gastrointestinal atresia
|
|
6.924E-5
|
5.462E-4
|
3.402E-3
|
1.966E-2
|
3
|
73
|
|
37
|
HP:0002101
|
Abnormal lung lobation
|
|
7.213E-5
|
5.537E-4
|
3.448E-3
|
2.049E-2
|
3
|
74
|
|
38
|
HP:0001274
|
Agenesis of corpus callosum
|
|
8.116E-5
|
5.919E-4
|
3.686E-3
|
2.305E-2
|
4
|
233
|
|
39
|
HP:0002187
|
Intellectual disability, profound
|
|
8.128E-5
|
5.919E-4
|
3.686E-3
|
2.308E-2
|
3
|
77
|
|
40
|
HP:0002916
|
Abnormality of chromosome segregation
|
|
8.778E-5
|
6.233E-4
|
3.882E-3
|
2.493E-2
|
3
|
79
|
|
41
|
HP:0010787
|
Genital neoplasm
|
|
9.121E-5
|
6.318E-4
|
3.935E-3
|
2.590E-2
|
4
|
240
|
|
42
|
HP:0001659
|
Aortic regurgitation
|
|
9.462E-5
|
6.398E-4
|
3.985E-3
|
2.687E-2
|
3
|
81
|
|
43
|
HP:0006989
|
Dysplastic corpus callosum
|
|
9.735E-5
|
6.429E-4
|
4.004E-3
|
2.765E-2
|
4
|
244
|
|
44
|
HP:0010786
|
Urinary tract neoplasm
|
|
1.054E-4
|
6.654E-4
|
4.144E-3
|
2.995E-2
|
4
|
249
|
|
45
|
HP:0000107
|
Renal cyst
|
|
1.054E-4
|
6.654E-4
|
4.144E-3
|
2.995E-2
|
4
|
249
|
|
46
|
HP:0002123
|
Generalized myoclonic seizures
|
|
1.132E-4
|
6.990E-4
|
4.353E-3
|
3.215E-2
|
3
|
86
|
|
47
|
HP:0000445
|
Wide nose
|
|
1.172E-4
|
7.082E-4
|
4.411E-3
|
3.329E-2
|
3
|
87
|
|
48
|
HP:0003003
|
Colon cancer
|
|
1.213E-4
|
7.176E-4
|
4.469E-3
|
3.445E-2
|
3
|
88
|
|
49
|
HP:0001680
|
Coarctation of aorta
|
|
1.255E-4
|
7.271E-4
|
4.529E-3
|
3.563E-2
|
3
|
89
|
|
50
|
HP:0002859
|
Rhabdomyosarcoma
|
|
1.385E-4
|
7.868E-4
|
4.900E-3
|
3.934E-2
|
3
|
92
|
Show 45 more annotations
|
5: Mouse Phenotype [Display Chart]
11 input genes in category / 303 annotations before applied cutoff / 10355 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
MP:0004023
|
abnormal chromosome number
|
|
8.063E-13
|
2.443E-10
|
1.537E-9
|
2.443E-10
|
7
|
88
|
|
2
|
MP:0003111
|
abnormal cell nucleus morphology
|
|
1.982E-12
|
3.003E-10
|
1.890E-9
|
6.007E-10
|
8
|
193
|
|
3
|
MP:0004024
|
aneuploidy
|
|
2.395E-11
|
2.419E-9
|
1.522E-8
|
7.256E-9
|
6
|
66
|
|
4
|
MP:0004046
|
abnormal mitosis
|
|
5.053E-11
|
3.828E-9
|
2.409E-8
|
1.531E-8
|
7
|
157
|
|
5
|
MP:0003077
|
abnormal cell cycle
|
|
1.559E-10
|
9.448E-9
|
5.946E-8
|
4.724E-8
|
8
|
332
|
|
6
|
MP:0011096
|
embryonic lethality between implantation and somite formation, complete penetrance
|
|
2.174E-9
|
1.098E-7
|
6.908E-7
|
6.587E-7
|
7
|
268
|
|
7
|
MP:0006205
|
embryonic lethality between implantation and somite formation
|
|
4.558E-9
|
1.973E-7
|
1.241E-6
|
1.381E-6
|
7
|
298
|
|
8
|
MP:0014137
|
abnormal preimplantation embryo morphology
|
|
2.597E-8
|
8.744E-7
|
5.503E-6
|
7.870E-6
|
6
|
208
|
|
9
|
MP:0004957
|
abnormal blastocyst morphology
|
|
2.597E-8
|
8.744E-7
|
5.503E-6
|
7.870E-6
|
6
|
208
|
|
10
|
MP:0009850
|
embryonic lethality between implantation and placentation
|
|
7.572E-8
|
2.294E-6
|
1.444E-5
|
2.294E-5
|
7
|
447
|
|
11
|
MP:0009760
|
abnormal mitotic spindle morphology
|
|
1.004E-7
|
2.691E-6
|
1.694E-5
|
3.043E-5
|
4
|
45
|
|
12
|
MP:0009762
|
abnormal mitotic spindle assembly checkpoint
|
|
1.066E-7
|
2.691E-6
|
1.694E-5
|
3.230E-5
|
3
|
10
|
|
13
|
MP:0008019
|
increased liver tumor incidence
|
|
1.756E-7
|
4.093E-6
|
2.576E-5
|
5.321E-5
|
5
|
139
|
|
14
|
MP:0010297
|
increased hepatobiliary system tumor incidence
|
|
1.954E-7
|
4.229E-6
|
2.661E-5
|
5.921E-5
|
5
|
142
|
|
15
|
MP:0002038
|
increased carcinoma incidence
|
|
3.187E-7
|
6.439E-6
|
4.052E-5
|
9.658E-5
|
6
|
317
|
|
16
|
MP:0004045
|
abnormal cell cycle checkpoint function
|
|
4.803E-7
|
9.096E-6
|
5.724E-5
|
1.455E-4
|
4
|
66
|
|
17
|
MP:0002018
|
increased malignant tumor incidence
|
|
1.131E-6
|
1.945E-5
|
1.224E-4
|
3.427E-4
|
6
|
393
|
|
18
|
MP:0002718
|
abnormal inner cell mass morphology
|
|
1.156E-6
|
1.945E-5
|
1.224E-4
|
3.501E-4
|
4
|
82
|
|
19
|
MP:0012431
|
increased lymphoma incidence
|
|
3.564E-6
|
5.684E-5
|
3.577E-4
|
1.080E-3
|
5
|
255
|
|
20
|
MP:0004965
|
inner cell mass degeneration
|
|
4.350E-6
|
6.590E-5
|
4.147E-4
|
1.318E-3
|
3
|
32
|
|
21
|
MP:0008866
|
chromosomal instability
|
|
5.142E-6
|
7.419E-5
|
4.668E-4
|
1.558E-3
|
4
|
119
|
|
22
|
MP:0010094
|
abnormal chromosome stability
|
|
5.495E-6
|
7.568E-5
|
4.762E-4
|
1.665E-3
|
4
|
121
|
|
23
|
MP:0010296
|
increased hemolymphoid system tumor incidence
|
|
8.568E-6
|
1.129E-4
|
7.103E-4
|
2.596E-3
|
5
|
305
|
|
24
|
MP:0008932
|
abnormal embryonic tissue physiology
|
|
1.019E-5
|
1.286E-4
|
8.091E-4
|
3.086E-3
|
5
|
316
|
|
25
|
MP:0010298
|
increased respiratory system tumor incidence
|
|
1.256E-5
|
1.464E-4
|
9.212E-4
|
3.806E-3
|
4
|
149
|
|
26
|
MP:0008014
|
increased lung tumor incidence
|
|
1.256E-5
|
1.464E-4
|
9.212E-4
|
3.806E-3
|
4
|
149
|
|
27
|
MP:0013504
|
increased embryonic tissue cell apoptosis
|
|
1.324E-5
|
1.486E-4
|
9.352E-4
|
4.013E-3
|
4
|
151
|
|
28
|
MP:0002021
|
increased incidence of induced tumors
|
|
1.925E-5
|
2.084E-4
|
1.311E-3
|
5.834E-3
|
4
|
166
|
|
29
|
MP:0013503
|
abnormal embryonic tissue cell apoptosis
|
|
2.767E-5
|
2.891E-4
|
1.819E-3
|
8.384E-3
|
4
|
182
|
|
30
|
MP:0003702
|
abnormal chromosome morphology
|
|
7.007E-5
|
7.077E-4
|
4.454E-3
|
2.123E-2
|
3
|
80
|
|
31
|
MP:0008007
|
abnormal cellular replicative senescence
|
|
9.316E-5
|
9.068E-4
|
5.706E-3
|
2.823E-2
|
3
|
88
|
|
32
|
MP:0013151
|
abnormal incidence of induced tumors
|
|
9.577E-5
|
9.068E-4
|
5.706E-3
|
2.902E-2
|
4
|
250
|
|
33
|
MP:0010264
|
increased hepatoma incidence
|
|
1.383E-4
|
1.270E-3
|
7.992E-3
|
4.191E-2
|
2
|
17
|
|
34
|
MP:0008714
|
increased lung carcinoma incidence
|
|
1.666E-4
|
1.485E-3
|
9.345E-3
|
5.049E-2
|
3
|
107
|
|
35
|
MP:0004760
|
increased mitotic index
|
|
1.929E-4
|
1.670E-3
|
1.051E-2
|
5.845E-2
|
2
|
20
|
|
36
|
MP:0001244
|
thin dermal layer
|
|
4.691E-4
|
3.948E-3
|
2.485E-2
|
1.421E-1
|
2
|
31
|
|
37
|
MP:0000162
|
lordosis
|
|
6.696E-4
|
5.483E-3
|
3.450E-2
|
2.029E-1
|
2
|
37
|
|
38
|
MP:0009308
|
increased adenocarcinoma incidence
|
|
7.567E-4
|
6.034E-3
|
3.797E-2
|
2.293E-1
|
3
|
179
|
|
39
|
MP:0011092
|
embryonic lethality, complete penetrance
|
|
9.176E-4
|
7.129E-3
|
4.486E-2
|
2.780E-1
|
4
|
451
|
|
40
|
MP:0002209
|
decreased germ cell number
|
|
1.331E-3
|
1.008E-2
|
6.343E-2
|
4.032E-1
|
4
|
498
|
|
41
|
MP:0002687
|
oligozoospermia
|
|
1.965E-3
|
1.452E-2
|
9.136E-2
|
5.953E-1
|
3
|
249
|
|
42
|
MP:0009315
|
increased rectum adenocarcinoma incidence
|
|
2.124E-3
|
1.532E-2
|
9.640E-2
|
6.434E-1
|
1
|
2
|
|
43
|
MP:0013500
|
abnormal fibroblast apoptosis
|
|
2.249E-3
|
1.549E-2
|
9.747E-2
|
6.816E-1
|
2
|
68
|
|
44
|
MP:0004966
|
abnormal inner cell mass proliferation
|
|
2.249E-3
|
1.549E-2
|
9.747E-2
|
6.816E-1
|
2
|
68
|
|
45
|
MP:0004028
|
chromosome breakage
|
|
2.518E-3
|
1.659E-2
|
1.044E-1
|
7.630E-1
|
2
|
72
|
|
46
|
MP:0003786
|
premature aging
|
|
2.518E-3
|
1.659E-2
|
1.044E-1
|
7.630E-1
|
2
|
72
|
|
47
|
MP:0003718
|
maternal effect
|
|
2.588E-3
|
1.668E-2
|
1.050E-1
|
7.840E-1
|
2
|
73
|
|
48
|
MP:0008008
|
early cellular replicative senescence
|
|
2.729E-3
|
1.723E-2
|
1.084E-1
|
8.269E-1
|
2
|
75
|
|
49
|
MP:0002027
|
increased lung adenocarcinoma incidence
|
|
2.948E-3
|
1.787E-2
|
1.124E-1
|
8.933E-1
|
2
|
78
|
|
50
|
MP:0009781
|
abnormal preimplantation embryo development
|
|
2.948E-3
|
1.787E-2
|
1.124E-1
|
8.933E-1
|
2
|
78
|
Show 45 more annotations
|
6: Domain [Display Chart]
12 input genes in category / 50 annotations before applied cutoff / 18735 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
PF08311
|
Mad3 BUB1 I
|
Pfam
|
3.761E-7
|
3.761E-6
|
1.692E-5
|
1.880E-5
|
2
|
2
|
|
2
|
SM00777
|
Mad3 BUB1 I
|
SMART
|
3.761E-7
|
3.761E-6
|
1.692E-5
|
1.880E-5
|
2
|
2
|
|
3
|
IPR015661
|
Bub1/Mad3
|
InterPro
|
3.761E-7
|
3.761E-6
|
1.692E-5
|
1.880E-5
|
2
|
2
|
|
4
|
PS51489
|
BUB1 N
|
PROSITE
|
3.761E-7
|
3.761E-6
|
1.692E-5
|
1.880E-5
|
2
|
2
|
|
5
|
IPR013212
|
Mad3/Bub1 I
|
InterPro
|
3.761E-7
|
3.761E-6
|
1.692E-5
|
1.880E-5
|
2
|
2
|
|
6
|
IPR030616
|
Aur
|
InterPro
|
1.128E-6
|
9.399E-6
|
4.229E-5
|
5.639E-5
|
2
|
3
|
|
7
|
IPR008271
|
Ser/Thr kinase AS
|
InterPro
|
5.686E-5
|
3.751E-4
|
1.688E-3
|
2.843E-3
|
4
|
357
|
|
8
|
PS00108
|
PROTEIN KINASE ST
|
PROSITE
|
6.002E-5
|
3.751E-4
|
1.688E-3
|
3.001E-3
|
4
|
362
|
|
9
|
PF00069
|
Pkinase
|
Pfam
|
7.323E-5
|
4.068E-4
|
1.830E-3
|
3.662E-3
|
4
|
381
|
|
10
|
PS00107
|
PROTEIN KINASE ATP
|
PROSITE
|
1.506E-4
|
7.528E-4
|
3.387E-3
|
7.528E-3
|
4
|
459
|
|
11
|
IPR000719
|
Prot kinase dom
|
InterPro
|
1.921E-4
|
8.258E-4
|
3.716E-3
|
9.605E-3
|
4
|
489
|
|
12
|
PS50011
|
PROTEIN KINASE DOM
|
PROSITE
|
1.982E-4
|
8.258E-4
|
3.716E-3
|
9.910E-3
|
4
|
493
|
|
13
|
IPR013218
|
Dsn1/Mis13
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
14
|
IPR030611
|
AURKA
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
15
|
IPR033187
|
CDC20
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
16
|
PF08202
|
MIS13
|
Pfam
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
17
|
IPR031887
|
SDCCAG8
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
18
|
PF06248
|
Zw10
|
Pfam
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
19
|
PS51700
|
SEPARIN
|
PROSITE
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
20
|
IPR009361
|
RZZ-complex Zw10
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
21
|
PF15964
|
CCCAP
|
Pfam
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
22
|
PF15556
|
Zwint
|
Pfam
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
23
|
IPR028772
|
AURKB
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
24
|
IPR030397
|
SEPARIN core dom
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
25
|
IPR029092
|
Zwint-1
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
26
|
IPR027097
|
Mad2
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
27
|
IPR005314
|
Peptidase C50
|
InterPro
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
28
|
PF03568
|
Peptidase C50
|
Pfam
|
6.405E-4
|
1.144E-3
|
5.146E-3
|
3.203E-2
|
1
|
1
|
|
29
|
IPR020636
|
Ca/CaM-dep Ca-dep prot Kinase
|
InterPro
|
8.615E-4
|
1.485E-3
|
6.683E-3
|
4.308E-2
|
2
|
69
|
|
30
|
SM00220
|
S TKc
|
SMART
|
1.350E-3
|
2.250E-3
|
1.012E-2
|
6.749E-2
|
3
|
359
|
|
31
|
IPR017441
|
Protein kinase ATP BS
|
InterPro
|
1.577E-3
|
2.544E-3
|
1.145E-2
|
7.887E-2
|
3
|
379
|
|
32
|
IPR033010
|
Cdc20/Fizzy
|
InterPro
|
1.920E-3
|
3.001E-3
|
1.350E-2
|
9.602E-2
|
1
|
3
|
|
33
|
PS50815
|
HORMA
|
PROSITE
|
2.560E-3
|
3.555E-3
|
1.600E-2
|
1.280E-1
|
1
|
4
|
|
34
|
3.30.900.10
|
-
|
Gene3D
|
2.560E-3
|
3.555E-3
|
1.600E-2
|
1.280E-1
|
1
|
4
|
|
35
|
IPR003511
|
HORMA dom
|
InterPro
|
2.560E-3
|
3.555E-3
|
1.600E-2
|
1.280E-1
|
1
|
4
|
|
36
|
PF02301
|
HORMA
|
Pfam
|
2.560E-3
|
3.555E-3
|
1.600E-2
|
1.280E-1
|
1
|
4
|
|
37
|
IPR011045
|
N2O reductase N
|
InterPro
|
9.568E-3
|
1.293E-2
|
5.818E-2
|
4.784E-1
|
1
|
15
|
|
38
|
PF00400
|
WD40
|
Pfam
|
1.147E-2
|
1.469E-2
|
6.607E-2
|
5.734E-1
|
2
|
259
|
|
39
|
SM00320
|
WD40
|
SMART
|
1.224E-2
|
1.469E-2
|
6.607E-2
|
6.120E-1
|
2
|
268
|
|
40
|
IPR001680
|
WD40 repeat
|
InterPro
|
1.259E-2
|
1.469E-2
|
6.607E-2
|
6.296E-1
|
2
|
272
|
|
41
|
PF12894
|
ANAPC4 WD40
|
Pfam
|
1.274E-2
|
1.469E-2
|
6.607E-2
|
6.370E-1
|
1
|
20
|
|
42
|
IPR024977
|
Apc4 WD40 dom
|
InterPro
|
1.274E-2
|
1.469E-2
|
6.607E-2
|
6.370E-1
|
1
|
20
|
|
43
|
PS00678
|
WD REPEATS 1
|
PROSITE
|
1.313E-2
|
1.469E-2
|
6.607E-2
|
6.563E-1
|
2
|
278
|
|
44
|
PS50082
|
WD REPEATS 2
|
PROSITE
|
1.322E-2
|
1.469E-2
|
6.607E-2
|
6.608E-1
|
2
|
279
|
|
45
|
PS50294
|
WD REPEATS REGION
|
PROSITE
|
1.322E-2
|
1.469E-2
|
6.607E-2
|
6.608E-1
|
2
|
279
|
|
46
|
IPR017986
|
WD40 repeat dom
|
InterPro
|
1.488E-2
|
1.618E-2
|
7.279E-2
|
7.442E-1
|
2
|
297
|
|
47
|
2.130.10.10
|
-
|
Gene3D
|
1.848E-2
|
1.947E-2
|
8.760E-2
|
9.240E-1
|
2
|
333
|
|
48
|
IPR015943
|
WD40/YVTN repeat-like dom
|
InterPro
|
1.869E-2
|
1.947E-2
|
8.760E-2
|
9.345E-1
|
2
|
335
|
Show 43 more annotations
|
7: Pathway [Display Chart]
13 input genes in category / 74 annotations before applied cutoff / 12450 genes in category
|
8: Pubmed [Display Chart]
13 input genes in category / 1923 annotations before applied cutoff / 38193 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
20231385
|
Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.
|
Pubmed
|
2.503E-22
|
4.813E-19
|
3.917E-18
|
4.813E-19
|
7
|
14
|
|
2
|
22000412
|
Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.
|
Pubmed
|
1.901E-18
|
9.138E-16
|
7.438E-15
|
3.655E-15
|
5
|
5
|
|
3
|
15525512
|
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
|
Pubmed
|
1.901E-18
|
9.138E-16
|
7.438E-15
|
3.655E-15
|
5
|
5
|
|
4
|
26148513
|
Dissecting the roles of human BUB1 in the spindle assembly checkpoint.
|
Pubmed
|
1.901E-18
|
9.138E-16
|
7.438E-15
|
3.655E-15
|
5
|
5
|
|
5
|
17981135
|
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
|
Pubmed
|
3.990E-17
|
1.535E-14
|
1.249E-13
|
7.674E-14
|
5
|
7
|
|
6
|
10366450
|
Characterization of MAD2B and other mitotic spindle checkpoint genes.
|
Pubmed
|
2.393E-16
|
7.671E-14
|
6.243E-13
|
4.603E-13
|
5
|
9
|
|
7
|
25669885
|
The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators.
|
Pubmed
|
4.786E-16
|
1.150E-13
|
9.364E-13
|
9.204E-13
|
5
|
10
|
|
8
|
21199919
|
Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.
|
Pubmed
|
4.786E-16
|
1.150E-13
|
9.364E-13
|
9.204E-13
|
5
|
10
|
|
9
|
26811472
|
Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.
|
Pubmed
|
9.213E-16
|
1.907E-13
|
1.552E-12
|
1.772E-12
|
6
|
37
|
|
10
|
26410627
|
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
|
Pubmed
|
9.916E-16
|
1.907E-13
|
1.552E-12
|
1.907E-12
|
8
|
212
|
|
11
|
15824131
|
ZW10 links mitotic checkpoint signaling to the structural kinetochore.
|
Pubmed
|
3.800E-15
|
6.642E-13
|
5.406E-12
|
7.307E-12
|
5
|
14
|
|
12
|
11702782
|
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.
|
Pubmed
|
8.066E-15
|
1.193E-12
|
9.711E-12
|
1.551E-11
|
4
|
4
|
|
13
|
20220147
|
Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition.
|
Pubmed
|
8.066E-15
|
1.193E-12
|
9.711E-12
|
1.551E-11
|
4
|
4
|
|
14
|
28410192
|
Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation.
|
Pubmed
|
1.209E-13
|
1.454E-11
|
1.183E-10
|
2.326E-10
|
4
|
6
|
|
15
|
21525009
|
BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.
|
Pubmed
|
1.209E-13
|
1.454E-11
|
1.183E-10
|
2.326E-10
|
4
|
6
|
|
16
|
19117984
|
Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner.
|
Pubmed
|
1.209E-13
|
1.454E-11
|
1.183E-10
|
2.326E-10
|
4
|
6
|
|
17
|
25852190
|
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
|
Pubmed
|
1.693E-13
|
1.915E-11
|
1.559E-10
|
3.256E-10
|
8
|
401
|
|
18
|
21440680
|
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
|
Pubmed
|
2.801E-13
|
2.170E-11
|
1.766E-10
|
5.387E-10
|
6
|
92
|
|
19
|
23791783
|
Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
20
|
27939943
|
The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
21
|
25383541
|
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
22
|
25482201
|
The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
23
|
22100920
|
p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
24
|
23643811
|
APC/C(Cdh1)-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
25
|
25012665
|
Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein.
|
Pubmed
|
2.821E-13
|
2.170E-11
|
1.766E-10
|
5.426E-10
|
4
|
7
|
|
26
|
25306918
|
Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate.
|
Pubmed
|
4.489E-13
|
3.320E-11
|
2.703E-10
|
8.633E-10
|
5
|
33
|
|
27
|
15388328
|
WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase.
|
Pubmed
|
5.642E-13
|
3.875E-11
|
3.154E-10
|
1.085E-9
|
4
|
8
|
|
28
|
24151075
|
Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex.
|
Pubmed
|
5.642E-13
|
3.875E-11
|
3.154E-10
|
1.085E-9
|
4
|
8
|
|
29
|
24464857
|
Stable MCC binding to the APC/C is required for a functional spindle assembly checkpoint.
|
Pubmed
|
1.692E-12
|
1.085E-10
|
8.827E-10
|
3.254E-9
|
4
|
10
|
|
30
|
19468067
|
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.
|
Pubmed
|
1.692E-12
|
1.085E-10
|
8.827E-10
|
3.254E-9
|
4
|
10
|
|
31
|
26912231
|
The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.
|
Pubmed
|
2.658E-12
|
1.649E-10
|
1.342E-9
|
5.112E-9
|
4
|
11
|
|
32
|
21926987
|
APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
|
Pubmed
|
3.987E-12
|
2.255E-10
|
1.835E-9
|
7.666E-9
|
4
|
12
|
|
33
|
26986935
|
Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.
|
Pubmed
|
3.987E-12
|
2.255E-10
|
1.835E-9
|
7.666E-9
|
4
|
12
|
|
34
|
23007648
|
Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.
|
Pubmed
|
3.987E-12
|
2.255E-10
|
1.835E-9
|
7.666E-9
|
4
|
12
|
|
35
|
25750436
|
MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.
|
Pubmed
|
5.757E-12
|
3.163E-10
|
2.575E-9
|
1.107E-8
|
4
|
13
|
|
36
|
27097363
|
NUP98 fusion oncoproteins interact with the APC/C(Cdc20) as a pseudosubstrate and prevent mitotic checkpoint complex binding.
|
Pubmed
|
8.059E-12
|
4.305E-10
|
3.504E-9
|
1.550E-8
|
4
|
14
|
|
37
|
23160376
|
Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.
|
Pubmed
|
1.915E-11
|
9.953E-10
|
8.101E-9
|
3.682E-8
|
4
|
17
|
|
38
|
11535616
|
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.
|
Pubmed
|
2.462E-11
|
1.097E-9
|
8.928E-9
|
4.734E-8
|
4
|
18
|
|
39
|
22193957
|
BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.
|
Pubmed
|
2.462E-11
|
1.097E-9
|
8.928E-9
|
4.734E-8
|
4
|
18
|
|
40
|
14593737
|
The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.
|
Pubmed
|
2.462E-11
|
1.097E-9
|
8.928E-9
|
4.734E-8
|
4
|
18
|
|
41
|
21407176
|
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
42
|
19154722
|
Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
43
|
24756216
|
BUB1 mRNA is significantly co-expressed with AURKA and AURKB mRNA in advanced-stage ovarian serous carcinoma.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
44
|
20459534
|
Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
45
|
25637637
|
Proteins of the mitotic checkpoint and spindle are related to chromosomal instability and unfavourable prognosis in patients with myelodysplastic syndrome.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
46
|
25661489
|
Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
47
|
21720555
|
Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
48
|
11274370
|
Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
49
|
22331848
|
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
|
50
|
11907259
|
Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex.
|
Pubmed
|
3.080E-11
|
1.097E-9
|
8.928E-9
|
5.924E-8
|
3
|
3
|
Show 45 more annotations
|
9: Interaction [Display Chart]
13 input genes in category / 913 annotations before applied cutoff / 17703 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
int:BUB1
|
BUB1 interactions
|
|
4.722E-18
|
2.238E-15
|
1.655E-14
|
4.311E-15
|
8
|
53
|
|
2
|
int:BUB1B
|
BUB1B interactions
|
|
4.901E-18
|
2.238E-15
|
1.655E-14
|
4.475E-15
|
9
|
106
|
|
3
|
int:NSL1
|
NSL1 interactions
|
|
1.870E-17
|
5.690E-15
|
4.208E-14
|
1.707E-14
|
7
|
28
|
|
4
|
int:KNL1
|
KNL1 interactions
|
|
1.315E-16
|
2.521E-14
|
1.864E-13
|
1.201E-13
|
7
|
36
|
|
5
|
int:NDC80
|
NDC80 interactions
|
|
1.381E-16
|
2.521E-14
|
1.864E-13
|
1.261E-13
|
8
|
79
|
|
6
|
int:NUF2
|
NUF2 interactions
|
|
2.073E-14
|
3.155E-12
|
2.333E-11
|
1.893E-11
|
7
|
71
|
|
7
|
int:CDC20
|
CDC20 interactions
|
|
9.145E-14
|
1.193E-11
|
8.820E-11
|
8.350E-11
|
8
|
174
|
|
8
|
int:BUB3
|
BUB3 interactions
|
|
2.474E-13
|
2.824E-11
|
2.088E-10
|
2.259E-10
|
7
|
100
|
|
9
|
int:ZWINT
|
ZWINT interactions
|
|
4.593E-13
|
4.660E-11
|
3.446E-10
|
4.194E-10
|
7
|
109
|
|
10
|
int:MAD2L1
|
MAD2L1 interactions
|
|
1.477E-11
|
1.349E-9
|
9.973E-9
|
1.349E-8
|
6
|
83
|
|
11
|
int:MIS12
|
MIS12 interactions
|
|
4.406E-11
|
3.657E-9
|
2.704E-8
|
4.022E-8
|
5
|
38
|
|
12
|
int:DSN1
|
DSN1 interactions
|
|
2.269E-10
|
1.726E-8
|
1.277E-7
|
2.072E-7
|
5
|
52
|
|
13
|
int:UBR5
|
UBR5 interactions
|
|
1.486E-9
|
1.044E-7
|
7.716E-7
|
1.357E-6
|
6
|
177
|
|
14
|
int:PMF1
|
PMF1 interactions
|
|
2.077E-9
|
1.354E-7
|
1.002E-6
|
1.896E-6
|
5
|
80
|
|
15
|
int:SPC25
|
SPC25 interactions
|
|
9.036E-9
|
5.500E-7
|
4.067E-6
|
8.250E-6
|
4
|
35
|
|
16
|
int:SPC24
|
SPC24 interactions
|
|
1.926E-8
|
1.099E-6
|
8.128E-6
|
1.759E-5
|
4
|
42
|
|
17
|
int:CDC27
|
CDC27 interactions
|
|
3.044E-8
|
1.635E-6
|
1.209E-5
|
2.780E-5
|
5
|
136
|
|
18
|
int:TP73
|
TP73 interactions
|
|
3.521E-8
|
1.786E-6
|
1.321E-5
|
3.215E-5
|
5
|
140
|
|
19
|
int:CENPK
|
CENPK interactions
|
|
3.950E-8
|
1.898E-6
|
1.404E-5
|
3.607E-5
|
4
|
50
|
|
20
|
int:CDC16
|
CDC16 interactions
|
|
6.876E-8
|
3.139E-6
|
2.321E-5
|
6.278E-5
|
5
|
160
|
|
21
|
int:ANAPC4
|
ANAPC4 interactions
|
|
7.254E-8
|
3.154E-6
|
2.332E-5
|
6.623E-5
|
4
|
58
|
|
22
|
int:MLF1
|
MLF1 interactions
|
|
1.016E-7
|
4.218E-6
|
3.119E-5
|
9.279E-5
|
4
|
63
|
|
23
|
int:TTK
|
TTK interactions
|
|
3.110E-7
|
1.235E-5
|
9.129E-5
|
2.839E-4
|
4
|
83
|
|
24
|
int:PTTG1
|
PTTG1 interactions
|
|
6.859E-7
|
2.609E-5
|
1.930E-4
|
6.263E-4
|
4
|
101
|
|
25
|
int:MAD2L1BP
|
MAD2L1BP interactions
|
|
1.516E-6
|
5.535E-5
|
4.093E-4
|
1.384E-3
|
3
|
32
|
|
26
|
int:TUBB
|
TUBB interactions
|
|
2.598E-6
|
9.124E-5
|
6.747E-4
|
2.372E-3
|
5
|
333
|
|
27
|
int:PPP2R5A
|
PPP2R5A interactions
|
|
2.784E-6
|
9.415E-5
|
6.962E-4
|
2.542E-3
|
3
|
39
|
|
28
|
int:NEK2
|
NEK2 interactions
|
|
4.923E-6
|
1.605E-4
|
1.187E-3
|
4.495E-3
|
3
|
47
|
|
29
|
int:FZR1
|
FZR1 interactions
|
|
6.294E-6
|
1.859E-4
|
1.375E-3
|
5.747E-3
|
4
|
176
|
|
30
|
int:AURKB
|
AURKB interactions
|
|
6.294E-6
|
1.859E-4
|
1.375E-3
|
5.747E-3
|
4
|
176
|
|
31
|
int:ZW10
|
ZW10 interactions
|
|
6.312E-6
|
1.859E-4
|
1.375E-3
|
5.763E-3
|
3
|
51
|
|
32
|
int:CENPM
|
CENPM interactions
|
|
6.696E-6
|
1.910E-4
|
1.413E-3
|
6.114E-3
|
3
|
52
|
|
33
|
int:ANAPC2
|
ANAPC2 interactions
|
|
7.095E-6
|
1.963E-4
|
1.451E-3
|
6.478E-3
|
3
|
53
|
|
34
|
int:CHFR
|
CHFR interactions
|
|
7.509E-6
|
2.016E-4
|
1.491E-3
|
6.856E-3
|
3
|
54
|
|
35
|
int:UBE2C
|
UBE2C interactions
|
|
1.378E-5
|
3.495E-4
|
2.585E-3
|
1.258E-2
|
3
|
66
|
|
36
|
int:ANAPC7
|
ANAPC7 interactions
|
|
1.378E-5
|
3.495E-4
|
2.585E-3
|
1.258E-2
|
3
|
66
|
|
37
|
int:APC
|
APC interactions
|
|
1.810E-5
|
4.372E-4
|
3.233E-3
|
1.653E-2
|
4
|
230
|
|
38
|
int:ANAPC1
|
ANAPC1 interactions
|
|
1.868E-5
|
4.372E-4
|
3.233E-3
|
1.705E-2
|
3
|
73
|
|
39
|
int:MAD1L1
|
MAD1L1 interactions
|
|
1.868E-5
|
4.372E-4
|
3.233E-3
|
1.705E-2
|
3
|
73
|
|
40
|
int:AP4B1
|
AP4B1 interactions
|
|
2.728E-5
|
6.226E-4
|
4.604E-3
|
2.490E-2
|
2
|
11
|
|
41
|
int:SKA3
|
SKA3 interactions
|
|
3.387E-5
|
7.543E-4
|
5.578E-3
|
3.093E-2
|
3
|
89
|
|
42
|
int:PLK1
|
PLK1 interactions
|
|
3.806E-5
|
8.273E-4
|
6.117E-3
|
3.474E-2
|
4
|
278
|
|
43
|
int:RASSF1
|
RASSF1 interactions
|
|
4.383E-5
|
9.306E-4
|
6.881E-3
|
4.001E-2
|
3
|
97
|
|
44
|
int:BRCA2
|
BRCA2 interactions
|
|
5.875E-5
|
1.219E-3
|
9.015E-3
|
5.364E-2
|
3
|
107
|
|
45
|
int:SUGT1
|
SUGT1 interactions
|
|
6.209E-5
|
1.260E-3
|
9.315E-3
|
5.669E-2
|
3
|
109
|
|
46
|
int:PPP1CC
|
PPP1CC interactions
|
|
7.777E-5
|
1.544E-3
|
1.141E-2
|
7.101E-2
|
4
|
334
|
|
47
|
int:RASIP1
|
RASIP1 interactions
|
|
8.453E-5
|
1.608E-3
|
1.189E-2
|
7.717E-2
|
2
|
19
|
|
48
|
int:PLK3
|
PLK3 interactions
|
|
8.453E-5
|
1.608E-3
|
1.189E-2
|
7.717E-2
|
2
|
19
|
|
49
|
int:CDC23
|
CDC23 interactions
|
|
9.334E-5
|
1.739E-3
|
1.286E-2
|
8.522E-2
|
3
|
125
|
|
50
|
int:CCNA2
|
CCNA2 interactions
|
|
9.557E-5
|
1.745E-3
|
1.290E-2
|
8.726E-2
|
3
|
126
|
Show 45 more annotations
|
10: Cytoband [Display Chart]
12 input genes in category / 12 annotations before applied cutoff / 34661 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
10q21-q22
|
10q21-q22
|
|
1.730E-3
|
1.360E-2
|
4.221E-2
|
2.076E-2
|
1
|
5
|
|
2
|
2q14
|
2q14
|
|
3.802E-3
|
1.360E-2
|
4.221E-2
|
4.563E-2
|
1
|
11
|
|
3
|
15q15
|
15q15
|
|
4.147E-3
|
1.360E-2
|
4.221E-2
|
4.977E-2
|
1
|
12
|
|
4
|
20q13
|
20q13
|
|
5.182E-3
|
1.360E-2
|
4.221E-2
|
6.218E-2
|
1
|
15
|
|
5
|
11q23.2
|
11q23.2
|
|
6.559E-3
|
1.360E-2
|
4.221E-2
|
7.871E-2
|
1
|
19
|
|
6
|
4q27
|
4q27
|
|
7.591E-3
|
1.360E-2
|
4.221E-2
|
9.110E-2
|
1
|
22
|
|
7
|
10q26
|
10q26
|
|
7.935E-3
|
1.360E-2
|
4.221E-2
|
9.522E-2
|
1
|
23
|
|
8
|
20q11.23
|
20q11.23
|
|
1.308E-2
|
1.962E-2
|
6.088E-2
|
1.569E-1
|
1
|
38
|
|
9
|
1q43
|
1q43
|
|
1.786E-2
|
2.134E-2
|
6.622E-2
|
2.143E-1
|
1
|
52
|
|
10
|
15q14
|
15q14
|
|
1.786E-2
|
2.134E-2
|
6.622E-2
|
2.143E-1
|
1
|
52
|
|
11
|
1p34.1
|
1p34.1
|
|
1.956E-2
|
2.134E-2
|
6.622E-2
|
2.347E-1
|
1
|
57
|
|
12
|
17p13.1
|
17p13.1
|
|
4.144E-2
|
4.144E-2
|
1.286E-1
|
4.972E-1
|
1
|
122
|
Show 7 more annotations
|
11: Transcription Factor Binding Site [Display Chart]
8 input genes in category / 49 annotations before applied cutoff / 9770 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
ACTAYRNNNCCCR UNKNOWN
|
ACTAYRNNNCCCR UNKNOWN
|
|
1.887E-6
|
9.247E-5
|
4.142E-4
|
9.247E-5
|
5
|
320
|
|
12: Gene Family [Display Chart]
7 input genes in category / 5 annotations before applied cutoff / 18194 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
694
|
Protein phosphatase 1 regulatory subunits
|
genenames.org
|
3.291E-5
|
1.646E-4
|
3.758E-4
|
1.646E-4
|
3
|
181
|
|
2
|
1338
|
Baculoviral IAP repeat containing|Chromosomal passenger complex
|
genenames.org
|
1.538E-3
|
2.564E-3
|
5.854E-3
|
7.691E-3
|
1
|
4
|
|
3
|
1322
|
MIS12 kinetochore complex
|
genenames.org
|
1.538E-3
|
2.564E-3
|
5.854E-3
|
7.691E-3
|
1
|
4
|
|
4
|
362
|
Ring finger proteins|WD repeat domain containing
|
genenames.org
|
4.136E-3
|
5.170E-3
|
1.181E-2
|
2.068E-2
|
2
|
262
|
|
5
|
980
|
Bardet-Biedl syndrome associated
|
genenames.org
|
8.053E-3
|
8.053E-3
|
1.839E-2
|
4.026E-2
|
1
|
21
|
|
13: Coexpression [Display Chart]
13 input genes in category / 1569 annotations before applied cutoff / 23137 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
20581836-TableS2
|
Human Sarcoma Chibon10 67genes genomeComplexityPredictor
|
GeneSigDB
|
1.844E-18
|
1.902E-15
|
1.509E-14
|
2.894E-15
|
8
|
61
|
|
2
|
19014521-TableS6c
|
Human Breast Reyal08 72genes
|
GeneSigDB
|
2.424E-18
|
1.902E-15
|
1.509E-14
|
3.804E-15
|
8
|
63
|
|
3
|
M3766
|
Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.180E-17
|
6.171E-15
|
4.897E-14
|
1.851E-14
|
9
|
151
|
|
4
|
16478745-SuppTable1
|
Human Breast Sotiriou06 242genes
|
GeneSigDB
|
1.126E-16
|
3.998E-14
|
3.173E-13
|
1.767E-13
|
9
|
193
|
|
5
|
18662380-S3-AURKA
|
Human Breast Wirapati08 355genes AURKA Module
|
GeneSigDB
|
1.274E-16
|
3.998E-14
|
3.173E-13
|
1.999E-13
|
10
|
344
|
|
6
|
16478745-SuppTable1-short
|
Human Breast Sotiriou06 128genes
|
GeneSigDB
|
1.600E-16
|
4.183E-14
|
3.320E-13
|
2.510E-13
|
8
|
104
|
|
7
|
17145885-SuppTable2
|
Human Lung Kobayashi06 320genes
|
GeneSigDB
|
1.072E-15
|
2.403E-13
|
1.907E-12
|
1.682E-12
|
9
|
247
|
|
8
|
M16010
|
Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.241E-15
|
2.434E-13
|
1.932E-12
|
1.947E-12
|
9
|
251
|
|
9
|
M15664
|
The 'Cervical Cancer Proliferation Cluster' (CCPC): genes whose expression in cervical carcinoma positively correlates with that of the HPV E6 and E7 oncogenes; they are also differentially expressed according to disease outcome.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.842E-15
|
3.210E-13
|
2.548E-12
|
2.889E-12
|
8
|
140
|
|
10
|
M10279
|
Genes down-regulated in primary endothelial cells (HUVEC) after knockdown of WTAP [GeneID=9589] by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
8.455E-15
|
1.327E-12
|
1.053E-11
|
1.327E-11
|
9
|
310
|
|
11
|
18498629-GeneList
|
Human Breast Loi08 239genes
|
GeneSigDB
|
1.305E-14
|
1.861E-12
|
1.477E-11
|
2.047E-11
|
8
|
178
|
|
12
|
M3155
|
Genes up-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.494E-14
|
1.954E-12
|
1.551E-11
|
2.345E-11
|
8
|
181
|
|
13
|
19351846-SuppTable3
|
Human Prostate Wang09 40genes
|
GeneSigDB
|
1.859E-14
|
2.243E-12
|
1.780E-11
|
2.916E-11
|
6
|
37
|
|
14
|
M14767
|
Genes down-regulated across the entire panel of NCI-60 cell lines in response to gamma radiation.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.066E-14
|
3.100E-12
|
2.460E-11
|
4.811E-11
|
6
|
40
|
|
15
|
M18506
|
Genes down-regulated in the ANBL-6 cell line (multiple myeloma, MM) after withdrawal of IL6 [GeneID=3569].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.305E-14
|
3.100E-12
|
2.460E-11
|
5.186E-11
|
7
|
98
|
|
16
|
M3577
|
Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those at day 10.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
3.359E-14
|
3.100E-12
|
2.460E-11
|
5.271E-11
|
8
|
200
|
|
17
|
M5901
|
Genes involved in the G2/M checkpoint, as in progression through the cell division cycle.
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
3.359E-14
|
3.100E-12
|
2.460E-11
|
5.271E-11
|
8
|
200
|
|
18
|
16919171-Table3
|
Human Colon Ancona06 45genes
|
GeneSigDB
|
4.188E-14
|
3.651E-12
|
2.897E-11
|
6.571E-11
|
6
|
42
|
|
19
|
M9516
|
Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.406E-13
|
1.161E-11
|
9.211E-11
|
2.205E-10
|
9
|
423
|
|
20
|
M1037
|
Genes up-regulated in gastric cancer cell lines: doxorubicin [PubChem=31703] resistant vs sensitive.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.056E-13
|
1.613E-11
|
1.280E-10
|
3.225E-10
|
6
|
54
|
|
21
|
M8520
|
Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.766E-13
|
2.067E-11
|
1.640E-10
|
4.341E-10
|
9
|
456
|
|
22
|
20630075-AF-2
|
Mouse StemCell GarciaEscudero10 371genes p53
|
GeneSigDB
|
3.264E-13
|
2.328E-11
|
1.847E-10
|
5.121E-10
|
8
|
265
|
|
23
|
18427120-DataS5
|
Human Breast Crawford08 187genes
|
GeneSigDB
|
4.470E-13
|
3.050E-11
|
2.420E-10
|
7.014E-10
|
7
|
141
|
|
24
|
17150101-TableS1h
|
Human Breast Troester06 364genes up DOX-MCF7
|
GeneSigDB
|
5.385E-13
|
3.520E-11
|
2.793E-10
|
8.448E-10
|
8
|
282
|
|
25
|
M14985
|
Genes up-regulated in SKOC-3 cells (ovarian cancer) after YB-1 (YBX1) [GeneID=4904] knockdown by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.743E-13
|
4.232E-11
|
3.359E-10
|
1.058E-9
|
8
|
290
|
|
26
|
19351846-SuppTable2
|
Human Prostate Wang09 181genes
|
GeneSigDB
|
1.148E-12
|
6.927E-11
|
5.497E-10
|
1.801E-9
|
7
|
161
|
|
27
|
M13108
|
Genes down-regulated in Wilm's tumor samples compared to fetal kidney.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.253E-12
|
7.281E-11
|
5.778E-10
|
1.966E-9
|
7
|
163
|
|
28
|
19043454-TableS2
|
Human Breast Thorner09 217genes
|
GeneSigDB
|
1.488E-12
|
8.339E-11
|
6.617E-10
|
2.335E-9
|
7
|
167
|
|
29
|
M18811
|
Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.552E-12
|
8.399E-11
|
6.665E-10
|
2.436E-9
|
7
|
168
|
|
30
|
M2156
|
Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.643E-12
|
8.593E-11
|
6.819E-10
|
2.578E-9
|
8
|
324
|
|
31
|
M2959
|
Genes up-regulated in induced T reg versus T conv.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
2.338E-12
|
1.184E-10
|
9.392E-10
|
3.669E-9
|
7
|
178
|
|
32
|
M2879
|
Selected genes down-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.535E-12
|
1.243E-10
|
9.864E-10
|
3.978E-9
|
8
|
342
|
|
33
|
21169407-TableS3
|
Human StemCell Shats10 100genes Consensus Stemness Ranking
|
GeneSigDB
|
4.583E-12
|
2.179E-10
|
1.729E-9
|
7.191E-9
|
6
|
89
|
|
34
|
M4912
|
Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 7 post-vaccination.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
4.791E-12
|
2.211E-10
|
1.754E-9
|
7.517E-9
|
7
|
197
|
|
35
|
M5294
|
Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 72 h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
5.331E-12
|
2.260E-10
|
1.794E-9
|
8.364E-9
|
7
|
200
|
|
36
|
M4626
|
Genes up-regulated in comparison of untreated CD25+ T effector cells at day 10 versus untreated CD25- T cells at day 10.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
5.331E-12
|
2.260E-10
|
1.794E-9
|
8.364E-9
|
7
|
200
|
|
37
|
M5925
|
Genes encoding cell cycle related targets of E2F transcription factors.
|
MSigDB H: Hallmark Gene Sets (v6.0)
|
5.331E-12
|
2.260E-10
|
1.794E-9
|
8.364E-9
|
7
|
200
|
|
38
|
M18855
|
Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.525E-11
|
6.297E-10
|
4.997E-9
|
2.393E-8
|
8
|
428
|
|
39
|
M17859
|
Genes down-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.664E-11
|
1.072E-9
|
8.506E-9
|
4.180E-8
|
8
|
459
|
|
40
|
15899795-SuppTable3
|
Human Breast Dai05 50genes
|
GeneSigDB
|
2.814E-11
|
1.104E-9
|
8.761E-9
|
4.416E-8
|
5
|
45
|
|
41
|
18199535-SuppTable3
|
Human StemCell Amundson08 138genes
|
GeneSigDB
|
3.847E-11
|
1.472E-9
|
1.168E-8
|
6.037E-8
|
6
|
126
|
|
42
|
20103679-ST3-D
|
Human Breast Wood10 71genes FoldChange>2
|
GeneSigDB
|
6.595E-11
|
2.407E-9
|
1.910E-8
|
1.035E-7
|
5
|
53
|
|
43
|
20103679-ST3-A
|
Human Breast Wood10 71genes CellCyle
|
GeneSigDB
|
6.595E-11
|
2.407E-9
|
1.910E-8
|
1.035E-7
|
5
|
53
|
|
44
|
16921376-GeneList
|
Human Breast Carter06 70genes
|
GeneSigDB
|
8.771E-11
|
3.128E-9
|
2.482E-8
|
1.376E-7
|
5
|
56
|
|
45
|
M9389
|
Genes in the red cluster of protein kinases distinguishing between luminal A and basal breast cancer subtypes.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.086E-10
|
3.704E-9
|
2.940E-8
|
1.704E-7
|
4
|
16
|
|
46
|
18245477-Table1
|
Human Breast Finetti08 16genes
|
GeneSigDB
|
1.086E-10
|
3.704E-9
|
2.940E-8
|
1.704E-7
|
4
|
16
|
|
47
|
17150101-TableS1l
|
Human Breast Troester06 436genes-up-DOX-ZR75-1
|
GeneSigDB
|
1.759E-10
|
5.873E-9
|
4.660E-8
|
2.760E-7
|
7
|
329
|
|
48
|
M7079
|
The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.996E-10
|
6.524E-9
|
5.178E-8
|
3.132E-7
|
7
|
335
|
|
49
|
M16108
|
Genes down-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.541E-10
|
8.138E-9
|
6.458E-8
|
3.988E-7
|
6
|
172
|
|
50
|
M3268
|
Top 200 marker genes up-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.127E-10
|
9.811E-9
|
7.786E-8
|
4.906E-7
|
6
|
178
|
Show 45 more annotations
|
14: Coexpression Atlas [Display Chart]
13 input genes in category / 554 annotations before applied cutoff / 21829 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/common lymphoid progenitor
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/common lymphoid progenitor
|
Tabula Muris Consortium
|
3.523E-14
|
1.018E-11
|
7.021E-11
|
1.952E-11
|
8
|
190
|
|
2
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis
|
Tabula Muris Consortium
|
3.676E-14
|
1.018E-11
|
7.021E-11
|
2.036E-11
|
8
|
191
|
|
3
|
GSM399397 500
|
alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.396E-13
|
1.282E-11
|
8.840E-11
|
7.733E-11
|
9
|
399
|
|
4
|
GSM399452 500
|
B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3
|
Immgen.org, GSE15907
|
1.745E-13
|
1.282E-11
|
8.840E-11
|
9.668E-11
|
9
|
409
|
|
5
|
GSM538387 500
|
alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3
|
Immgen.org, GSE15907
|
1.784E-13
|
1.282E-11
|
8.840E-11
|
9.884E-11
|
9
|
410
|
|
6
|
GSM399403 500
|
alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.078E-13
|
1.282E-11
|
8.840E-11
|
1.151E-10
|
9
|
417
|
|
7
|
GSM538350 500
|
B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1
|
Immgen.org, GSE15907
|
2.124E-13
|
1.282E-11
|
8.840E-11
|
1.177E-10
|
9
|
418
|
|
8
|
GSM538348 500
|
B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2
|
Immgen.org, GSE15907
|
2.170E-13
|
1.282E-11
|
8.840E-11
|
1.202E-10
|
9
|
419
|
|
9
|
GSM538355 500
|
B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2
|
Immgen.org, GSE15907
|
2.314E-13
|
1.282E-11
|
8.840E-11
|
1.282E-10
|
9
|
422
|
|
10
|
GSM538357 500
|
B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1
|
Immgen.org, GSE15907
|
2.314E-13
|
1.282E-11
|
8.840E-11
|
1.282E-10
|
9
|
422
|
|
11
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mitotic
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mitotic
|
BrainMap
|
5.161E-12
|
2.474E-10
|
1.706E-9
|
2.859E-9
|
7
|
188
|
|
12
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/late pro-B cell
|
Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/late pro-B cell
|
Tabula Muris Consortium
|
5.358E-12
|
2.474E-10
|
1.706E-9
|
2.969E-9
|
7
|
189
|
|
13
|
GSM791154 500
|
alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
8.591E-12
|
3.661E-10
|
2.524E-9
|
4.759E-9
|
8
|
376
|
|
14
|
GSM791143 500
|
alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.326E-11
|
5.203E-10
|
3.587E-9
|
7.349E-9
|
8
|
397
|
|
15
|
GSM538358 500
|
B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3
|
Immgen.org, GSE15907
|
1.409E-11
|
5.203E-10
|
3.587E-9
|
7.804E-9
|
8
|
400
|
|
16
|
GSM791149 500
|
alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.819E-11
|
6.042E-10
|
4.166E-9
|
1.007E-8
|
8
|
413
|
|
17
|
GSM476660 500
|
gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3
|
Immgen.org, GSE15907
|
1.854E-11
|
6.042E-10
|
4.166E-9
|
1.027E-8
|
8
|
414
|
|
18
|
GSM476664 500
|
gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3
|
Immgen.org, GSE15907
|
2.040E-11
|
6.064E-10
|
4.181E-9
|
1.130E-8
|
8
|
419
|
|
19
|
GSM791141 500
|
alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2
|
Immgen.org, GSE15907
|
2.080E-11
|
6.064E-10
|
4.181E-9
|
1.152E-8
|
8
|
420
|
|
20
|
GSM791131 500
|
B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3
|
Immgen.org, GSE15907
|
2.286E-11
|
6.331E-10
|
4.366E-9
|
1.266E-8
|
8
|
425
|
|
21
|
Lungmap Mouse Lung E16.5 Proliferative fibroblast
|
Lungmap Mouse Lung E16.5 Proliferative fibroblast
|
Lungmap CCHMC
|
4.007E-11
|
1.057E-9
|
7.288E-9
|
2.220E-8
|
8
|
456
|
|
22
|
6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes
|
6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes
|
|
1.570E-10
|
3.954E-9
|
2.726E-8
|
8.699E-8
|
6
|
150
|
|
23
|
GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 200 Genes
|
GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 200 Genes
|
GSE76381_EmbryoMoleculeCountsPMLog2
|
1.776E-10
|
4.279E-9
|
2.950E-8
|
9.841E-8
|
7
|
311
|
|
24
|
Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Astrocytoma/3/1
|
Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Astrocytoma/3/1
|
TCGA-Brain
|
3.007E-10
|
6.942E-9
|
4.787E-8
|
1.666E-7
|
6
|
167
|
|
25
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes
|
BrainMap
|
5.056E-10
|
9.337E-9
|
6.438E-8
|
2.801E-7
|
6
|
182
|
|
26
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200
|
BrainMap
|
5.056E-10
|
9.337E-9
|
6.438E-8
|
2.801E-7
|
6
|
182
|
|
27
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200
|
BrainMap
|
5.056E-10
|
9.337E-9
|
6.438E-8
|
2.801E-7
|
6
|
182
|
|
28
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes
|
|
5.056E-10
|
9.337E-9
|
6.438E-8
|
2.801E-7
|
6
|
182
|
|
29
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes
|
BrainMap
|
5.056E-10
|
9.337E-9
|
6.438E-8
|
2.801E-7
|
6
|
182
|
|
30
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes
|
BrainMap
|
5.056E-10
|
9.337E-9
|
6.438E-8
|
2.801E-7
|
6
|
182
|
|
31
|
GSM605784 500
|
gamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3
|
Immgen.org, GSE15907
|
5.228E-10
|
9.343E-9
|
6.442E-8
|
2.896E-7
|
7
|
363
|
|
32
|
GSM605781 500
|
gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3
|
Immgen.org, GSE15907
|
6.318E-10
|
1.094E-8
|
7.542E-8
|
3.500E-7
|
7
|
373
|
|
33
|
GSM538207 500
|
B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3
|
Immgen.org, GSE15907
|
7.191E-10
|
1.207E-8
|
8.324E-8
|
3.984E-7
|
7
|
380
|
|
34
|
10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes
|
10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes
|
|
8.929E-10
|
1.455E-8
|
1.003E-7
|
4.946E-7
|
7
|
392
|
|
35
|
GSM791114 500
|
Stem Cells, SC.CDP.BM, Sca1- Flt3+ MCSFR+ cKitlo, Bone marrow, avg-3
|
Immgen.org, GSE15907
|
1.046E-9
|
1.593E-8
|
1.098E-7
|
5.793E-7
|
7
|
401
|
|
36
|
GSM791105 500
|
Stem Cells, SC.MDP.BM, Sca1- Flt3+ MCSFR+ cKithi, Bone marrow, avg-3
|
Immgen.org, GSE15907
|
1.064E-9
|
1.593E-8
|
1.098E-7
|
5.894E-7
|
7
|
402
|
|
37
|
GSM399450 500
|
B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2
|
Immgen.org, GSE15907
|
1.064E-9
|
1.593E-8
|
1.098E-7
|
5.894E-7
|
7
|
402
|
|
38
|
6mo cortical organoids wt 6mo cortical organoids wt nan static Subtype 9 Top 100 Genes
|
6mo cortical organoids wt 6mo cortical organoids wt nan static Subtype 9 Top 100 Genes
|
|
1.665E-9
|
2.428E-8
|
1.674E-7
|
9.225E-7
|
5
|
94
|
|
39
|
GSM538354 500
|
B cells, proB.FrA.BM, AA4.1+ CD117+ IL7R+ CD45R+ CD24- CD19- IgM-, Bone marrow, avg-1
|
Immgen.org, GSE15907
|
1.098E-8
|
1.559E-7
|
1.075E-6
|
6.082E-6
|
6
|
304
|
|
40
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes
|
BrainMap
|
1.491E-8
|
1.966E-7
|
1.356E-6
|
8.257E-6
|
6
|
320
|
|
41
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes
|
|
1.491E-8
|
1.966E-7
|
1.356E-6
|
8.257E-6
|
6
|
320
|
|
42
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200
|
|
1.491E-8
|
1.966E-7
|
1.356E-6
|
8.257E-6
|
6
|
320
|
|
43
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes
|
BrainMap
|
1.635E-8
|
2.106E-7
|
1.452E-6
|
9.056E-6
|
6
|
325
|
|
44
|
GSM605778 500
|
gamma delta T cells, Tgd.vg1+vd6+.Th.TCRbko, TCRd+ Vg1.1+ Vd6.3+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.727E-8
|
2.172E-7
|
1.498E-6
|
9.566E-6
|
6
|
328
|
|
45
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Dlx1
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Dlx1
|
BrainMap
|
1.764E-8
|
2.172E-7
|
1.498E-6
|
9.773E-6
|
5
|
150
|
|
46
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes
|
BrainMap
|
2.414E-8
|
2.907E-7
|
2.005E-6
|
1.337E-5
|
6
|
347
|
|
47
|
GSM476675 500
|
gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3
|
Immgen.org, GSE15907
|
2.498E-8
|
2.944E-7
|
2.030E-6
|
1.384E-5
|
6
|
349
|
|
48
|
10X Human 8K PBMC CD4 T cells Subtype CD4 T cells-RP5-1171I10.5, GZMA, CCL5 Top 200 Genes
|
10X Human 8K PBMC CD4 T cells Subtype CD4 T cells-RP5-1171I10.5, GZMA, CCL5 Top 200 Genes
|
|
2.955E-8
|
3.410E-7
|
2.352E-6
|
1.637E-5
|
6
|
359
|
|
49
|
6mo cortical organoids wt 6mo cortical organoids wt Subtype mature neuron 1 s9 mature neuron 1 Subtype mature neuron 1 s9 Top 100 Genes
|
6mo cortical organoids wt 6mo cortical organoids wt Subtype mature neuron 1 s9 mature neuron 1 Subtype mature neuron 1 s9 Top 100 Genes
|
|
3.931E-8
|
4.378E-7
|
3.019E-6
|
2.178E-5
|
5
|
176
|
|
50
|
GSM538418 500
|
B cells, proB.FrBC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-1
|
Immgen.org, GSE15907
|
3.951E-8
|
4.378E-7
|
3.019E-6
|
2.189E-5
|
6
|
377
|
Show 45 more annotations
|
15: Computational [Display Chart]
10 input genes in category / 111 annotations before applied cutoff / 10037 genes in category
|
16: MicroRNA [Display Chart]
13 input genes in category / 479 annotations before applied cutoff / 72241 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
hsa-miR-633:Functional MTI
|
Functional MTI
|
miRTarbase
|
3.852E-7
|
1.845E-4
|
1.246E-3
|
1.845E-4
|
3
|
81
|
|
2
|
hsa-miR-378j:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.098E-5
|
4.670E-3
|
3.152E-2
|
1.963E-2
|
2
|
53
|
|
3
|
hsa-miR-6839-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.098E-5
|
4.670E-3
|
3.152E-2
|
1.963E-2
|
2
|
53
|
|
4
|
hsa-miR-149-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
4.522E-5
|
4.670E-3
|
3.152E-2
|
2.166E-2
|
3
|
397
|
|
5
|
hsa-miR-1179:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.085E-5
|
4.670E-3
|
3.152E-2
|
2.436E-2
|
2
|
59
|
|
6
|
hsa-miR-885-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
5.989E-5
|
4.670E-3
|
3.152E-2
|
2.869E-2
|
2
|
64
|
|
7
|
hsa-miR-4326:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.586E-5
|
4.670E-3
|
3.152E-2
|
3.634E-2
|
2
|
72
|
|
8
|
hsa-miR-6748-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.799E-5
|
4.670E-3
|
3.152E-2
|
3.736E-2
|
2
|
73
|
|
9
|
hsa-miR-3975:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
9.372E-5
|
4.950E-3
|
3.341E-2
|
4.489E-2
|
2
|
80
|
|
10
|
hsa-miR-4790-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.033E-4
|
4.950E-3
|
3.341E-2
|
4.950E-2
|
2
|
84
|
|
11
|
hsa-miR-4327:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.350E-4
|
5.868E-3
|
3.961E-2
|
6.467E-2
|
2
|
96
|
|
12
|
hsa-miR-497-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.494E-4
|
5.868E-3
|
3.961E-2
|
7.159E-2
|
2
|
101
|
|
13
|
hsa-miR-3674:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.709E-4
|
5.868E-3
|
3.961E-2
|
8.185E-2
|
2
|
108
|
|
14
|
hsa-miR-605-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.805E-4
|
5.868E-3
|
3.961E-2
|
8.645E-2
|
2
|
111
|
|
15
|
hsa-miR-188-5p:Non-Functional MTI
|
Non-Functional MTI
|
miRTarbase
|
1.837E-4
|
5.868E-3
|
3.961E-2
|
8.802E-2
|
2
|
112
|
|
16
|
hsa-miR-193a-3p:Non-Functional MTI
|
Non-Functional MTI
|
miRTarbase
|
2.399E-4
|
7.181E-3
|
4.847E-2
|
1.149E-1
|
2
|
128
|
|
17
|
hsa-miR-6771-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.172E-4
|
1.085E-2
|
7.325E-2
|
1.998E-1
|
2
|
169
|
|
18
|
hsa-miR-5699-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.421E-4
|
1.085E-2
|
7.325E-2
|
2.118E-1
|
2
|
174
|
|
19
|
hsa-miR-4421:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.421E-4
|
1.085E-2
|
7.325E-2
|
2.118E-1
|
2
|
174
|
|
20
|
hsa-miR-208a:mirSVR highEffct
|
hsa-miR-208a:mirSVR conserved highEffect-0.5
|
MicroRNA.org
|
4.677E-4
|
1.085E-2
|
7.325E-2
|
2.240E-1
|
2
|
179
|
|
21
|
hsa-miR-106a-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.834E-4
|
1.085E-2
|
7.325E-2
|
2.316E-1
|
2
|
182
|
|
22
|
hsa-miR-5680:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.211E-4
|
1.085E-2
|
7.325E-2
|
2.496E-1
|
2
|
189
|
|
23
|
hsa-miR-208b:mirSVR highEffct
|
hsa-miR-208b:mirSVR conserved highEffect-0.5
|
MicroRNA.org
|
5.211E-4
|
1.085E-2
|
7.325E-2
|
2.496E-1
|
2
|
189
|
|
24
|
hsa-miR-6876-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.773E-4
|
1.106E-2
|
7.466E-2
|
2.765E-1
|
2
|
199
|
|
25
|
hsa-miR-4476:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
5.773E-4
|
1.106E-2
|
7.466E-2
|
2.765E-1
|
2
|
199
|
|
26
|
hsa-miR-6746-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.182E-4
|
1.139E-2
|
7.688E-2
|
2.961E-1
|
2
|
206
|
|
27
|
hsa-miR-539-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
6.423E-4
|
1.139E-2
|
7.691E-2
|
3.077E-1
|
2
|
210
|
|
28
|
hsa-miR-6736-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
8.647E-4
|
1.479E-2
|
9.985E-2
|
4.142E-1
|
2
|
244
|
|
29
|
hsa-miR-409-5p:mirSVR highEffct
|
hsa-miR-409-5p:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
1.135E-3
|
1.875E-2
|
1.266E-1
|
5.437E-1
|
2
|
280
|
|
30
|
hsa-miR-4755-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.258E-3
|
2.009E-2
|
1.356E-1
|
6.027E-1
|
2
|
295
|
|
31
|
hsa-miR-196a-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.327E-3
|
2.050E-2
|
1.384E-1
|
6.354E-1
|
2
|
303
|
|
32
|
hsa-miR-499a-5p:TargetScan
|
hsa-miR-499a-5p
|
TargetScan
|
1.423E-3
|
2.130E-2
|
1.438E-1
|
6.817E-1
|
2
|
314
|
|
33
|
hsa-let-7i-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.607E-3
|
2.333E-2
|
1.575E-1
|
7.699E-1
|
2
|
334
|
|
34
|
hsa-miR-340-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.674E-3
|
2.359E-2
|
1.592E-1
|
8.020E-1
|
2
|
341
|
|
35
|
hsa-miR-183-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.772E-3
|
2.425E-2
|
1.637E-1
|
8.489E-1
|
2
|
351
|
|
36
|
hsa-miR-6504-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.935E-3
|
2.561E-2
|
1.728E-1
|
9.267E-1
|
2
|
367
|
|
37
|
hsa-miR-369-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.978E-3
|
2.561E-2
|
1.728E-1
|
9.474E-1
|
1
|
11
|
|
38
|
hsa-miR-127-3p:mirSVR lowEffct
|
hsa-miR-127-3p:mirSVR conserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.072E-3
|
2.611E-2
|
1.763E-1
|
9.923E-1
|
2
|
380
|
|
39
|
hsa-miR-450a-1-3p:Functional MTI
|
Functional MTI
|
miRTarbase
|
2.202E-3
|
2.650E-2
|
1.789E-1
|
1.000E0
|
2
|
392
|
|
40
|
hsa-let-7d-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
2.224E-3
|
2.650E-2
|
1.789E-1
|
1.000E0
|
2
|
394
|
|
41
|
hsa-miR-638:mirSVR lowEffct
|
hsa-miR-638:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.269E-3
|
2.650E-2
|
1.789E-1
|
1.000E0
|
2
|
398
|
|
42
|
hsa-miR-6082:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.337E-3
|
2.665E-2
|
1.799E-1
|
1.000E0
|
1
|
13
|
|
43
|
hsa-miR-383-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.521E-3
|
2.808E-2
|
1.896E-1
|
1.000E0
|
2
|
420
|
|
44
|
hsa-miR-8053:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.696E-3
|
2.935E-2
|
1.981E-1
|
1.000E0
|
1
|
15
|
|
45
|
hsa-miR-186-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.936E-3
|
3.125E-2
|
2.110E-1
|
1.000E0
|
2
|
454
|
|
46
|
hsa-miR-4722-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
3.051E-3
|
3.136E-2
|
2.117E-1
|
1.000E0
|
2
|
463
|
|
47
|
hsa-miR-6727-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
3.077E-3
|
3.136E-2
|
2.117E-1
|
1.000E0
|
2
|
465
|
|
48
|
hsa-miR-4284:mirSVR highEffct
|
hsa-miR-4284:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
3.234E-3
|
3.227E-2
|
2.178E-1
|
1.000E0
|
2
|
477
|
|
49
|
hsa-miR-769-3p:mirSVR highEffct
|
hsa-miR-769-3p:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
3.435E-3
|
3.358E-2
|
2.267E-1
|
1.000E0
|
2
|
492
|
|
50
|
hsa-miR-6717-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
4.131E-3
|
3.958E-2
|
2.672E-1
|
1.000E0
|
1
|
23
|
Show 45 more annotations
|
17: Drug [Display Chart]
13 input genes in category / 1505 annotations before applied cutoff / 22841 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
CID000004122
|
nocodazole
|
Stitch
|
7.853E-20
|
1.182E-16
|
9.330E-16
|
1.182E-16
|
12
|
478
|
|
2
|
CID009914412
|
ZM447439
|
Stitch
|
1.074E-16
|
8.085E-14
|
6.382E-13
|
1.617E-13
|
6
|
17
|
|
3
|
ctd:D008154
|
Lucanthone
|
CTD
|
2.984E-16
|
1.497E-13
|
1.182E-12
|
4.492E-13
|
9
|
212
|
|
4
|
CID000351065
|
bu-b
|
Stitch
|
6.316E-15
|
2.376E-12
|
1.876E-11
|
9.505E-12
|
7
|
77
|
|
5
|
ctd:C072581
|
16-hydroxycleroda-3,13(14)-dien-15,16-olide
|
CTD
|
1.417E-11
|
4.264E-9
|
3.366E-8
|
2.132E-8
|
5
|
39
|
|
6
|
ctd:D000069439
|
Dasatinib
|
CTD
|
4.075E-11
|
1.000E-8
|
7.894E-8
|
6.133E-8
|
8
|
478
|
|
7
|
ctd:C070081
|
fulvestrant
|
CTD
|
4.651E-11
|
1.000E-8
|
7.894E-8
|
7.000E-8
|
8
|
486
|
|
8
|
ctd:C063002
|
2,3-dimethoxy-1,4-naphthoquinone
|
CTD
|
1.351E-10
|
2.542E-8
|
2.007E-7
|
2.034E-7
|
6
|
153
|
|
9
|
ctd:D007840
|
Latex
|
CTD
|
5.165E-10
|
8.354E-8
|
6.595E-7
|
7.774E-7
|
6
|
191
|
|
10
|
ctd:C464760
|
copper-1,10-phenanthroline
|
CTD
|
5.551E-10
|
8.354E-8
|
6.595E-7
|
8.354E-7
|
4
|
23
|
|
11
|
ctd:D020123
|
Sirolimus
|
CTD
|
1.926E-9
|
2.467E-7
|
1.948E-6
|
2.898E-6
|
7
|
458
|
|
12
|
CID000005510
|
tolnaftate
|
Stitch
|
1.967E-9
|
2.467E-7
|
1.948E-6
|
2.961E-6
|
4
|
31
|
|
13
|
CID000028780
|
benomyl
|
Stitch
|
6.343E-9
|
7.343E-7
|
5.797E-6
|
9.546E-6
|
5
|
128
|
|
14
|
CID000448763
|
1tom
|
Stitch
|
1.553E-8
|
1.669E-6
|
1.318E-5
|
2.337E-5
|
4
|
51
|
|
15
|
CID002759434
|
2-morpholinoethyl isocyanide
|
Stitch
|
2.450E-8
|
2.458E-6
|
1.940E-5
|
3.687E-5
|
4
|
57
|
|
16
|
ctd:C500026
|
palbociclib
|
CTD
|
2.719E-8
|
2.552E-6
|
2.014E-5
|
4.092E-5
|
5
|
171
|
|
17
|
ctd:C001899
|
triptolide
|
CTD
|
2.882E-8
|
2.552E-6
|
2.014E-5
|
4.338E-5
|
5
|
173
|
|
18
|
904 DN
|
5109870; Down 200; 25uM; MCF7; HT HG-U133A EA
|
Broad Institute CMAP Down
|
3.419E-8
|
2.785E-6
|
2.198E-5
|
5.145E-5
|
5
|
179
|
|
19
|
5027 DN
|
Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
3.515E-8
|
2.785E-6
|
2.198E-5
|
5.291E-5
|
5
|
180
|
|
20
|
3317 DN
|
Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
3.818E-8
|
2.873E-6
|
2.268E-5
|
5.747E-5
|
5
|
183
|
|
21
|
3241 DN
|
Etoposide [33419-42-0]; Down 200; 6.8uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
4.032E-8
|
2.889E-6
|
2.281E-5
|
6.068E-5
|
5
|
185
|
|
22
|
5023 DN
|
Ciclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
4.255E-8
|
2.910E-6
|
2.298E-5
|
6.403E-5
|
5
|
187
|
|
23
|
ctd:C006551
|
2-amino-2-methyl-1-propanol
|
CTD
|
8.899E-7
|
5.823E-5
|
4.597E-4
|
1.339E-3
|
5
|
345
|
|
24
|
ctd:C550258
|
MLN 8237
|
CTD
|
1.793E-6
|
1.124E-4
|
8.876E-4
|
2.698E-3
|
2
|
4
|
|
25
|
ctd:C058305
|
phenethyl isothiocyanate
|
CTD
|
1.981E-6
|
1.193E-4
|
9.415E-4
|
2.982E-3
|
5
|
406
|
|
26
|
958 DN
|
resveratrol; Down 200; 10uM; MCF7; HT HG-U133A EA
|
Broad Institute CMAP Down
|
2.307E-6
|
1.315E-4
|
1.038E-3
|
3.472E-3
|
4
|
176
|
|
27
|
841 DN
|
resveratrol; Down 200; 10uM; MCF7; HT HG-U133A EA
|
Broad Institute CMAP Down
|
2.360E-6
|
1.315E-4
|
1.038E-3
|
3.552E-3
|
4
|
177
|
|
28
|
5000 DN
|
Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
2.874E-6
|
1.443E-4
|
1.139E-3
|
4.326E-3
|
4
|
186
|
|
29
|
595 DN
|
resveratrol; Down 200; 50uM; MCF7; HG-U133A
|
Broad Institute CMAP Down
|
2.999E-6
|
1.443E-4
|
1.139E-3
|
4.514E-3
|
4
|
188
|
|
30
|
ctd:C053541
|
bicalutamide
|
CTD
|
2.999E-6
|
1.443E-4
|
1.139E-3
|
4.514E-3
|
4
|
188
|
|
31
|
5312 DN
|
Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
3.063E-6
|
1.443E-4
|
1.139E-3
|
4.610E-3
|
4
|
189
|
|
32
|
622 DN
|
resveratrol; Down 200; 50uM; MCF7; HG-U133A
|
Broad Institute CMAP Down
|
3.128E-6
|
1.443E-4
|
1.139E-3
|
4.707E-3
|
4
|
190
|
|
33
|
7176 DN
|
Trifluridine [70-00-8]; Down 200; 13.6uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
3.261E-6
|
1.443E-4
|
1.139E-3
|
4.907E-3
|
4
|
192
|
|
34
|
1599 DN
|
Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; HL60; HG-U133A
|
Broad Institute CMAP Down
|
3.261E-6
|
1.443E-4
|
1.139E-3
|
4.907E-3
|
4
|
192
|
|
35
|
CID000794323
|
S)-monastrol
|
Stitch
|
3.513E-6
|
1.511E-4
|
1.192E-3
|
5.287E-3
|
3
|
54
|
|
36
|
ctd:D015739
|
Nocodazole
|
CTD
|
5.608E-6
|
2.344E-4
|
1.851E-3
|
8.439E-3
|
3
|
63
|
|
37
|
ctd:D048789
|
Phytoestrogens
|
CTD
|
6.756E-6
|
2.748E-4
|
2.169E-3
|
1.017E-2
|
3
|
67
|
|
38
|
CID000005097
|
NSC683246
|
Stitch
|
7.139E-6
|
2.828E-4
|
2.232E-3
|
1.074E-2
|
4
|
234
|
|
39
|
ctd:D014747
|
Vinblastine
|
CTD
|
1.098E-5
|
4.239E-4
|
3.346E-3
|
1.653E-2
|
4
|
261
|
|
40
|
ctd:C484810
|
VX680
|
CTD
|
1.640E-5
|
6.020E-4
|
4.752E-3
|
2.468E-2
|
2
|
11
|
|
41
|
CID003031661
|
6,7-dimethoxyquinazoline
|
Stitch
|
1.640E-5
|
6.020E-4
|
4.752E-3
|
2.468E-2
|
2
|
11
|
|
42
|
CID000005798
|
benzimidazole
|
Stitch
|
1.814E-5
|
6.502E-4
|
5.133E-3
|
2.731E-2
|
3
|
93
|
|
43
|
CID000004111
|
AC1L1HFP
|
Stitch
|
1.934E-5
|
6.769E-4
|
5.344E-3
|
2.911E-2
|
3
|
95
|
|
44
|
CID000021768
|
geranyl nitrile
|
Stitch
|
2.324E-5
|
7.950E-4
|
6.276E-3
|
3.498E-2
|
2
|
13
|
|
45
|
ctd:C008461
|
methyl isocyanate
|
CTD
|
4.047E-5
|
1.354E-3
|
1.069E-2
|
6.091E-2
|
2
|
17
|
|
46
|
CID000012391
|
pentadecane
|
Stitch
|
5.086E-5
|
1.664E-3
|
1.313E-2
|
7.654E-2
|
2
|
19
|
|
47
|
ctd:C059765
|
amphotericin B, deoxycholate drug combination
|
CTD
|
5.297E-5
|
1.696E-3
|
1.339E-2
|
7.972E-2
|
4
|
390
|
|
48
|
ctd:C024015
|
cryptolepine
|
CTD
|
7.515E-5
|
2.356E-3
|
1.860E-2
|
1.131E-1
|
2
|
23
|
|
49
|
CID000072271
|
UCN-01
|
Stitch
|
8.180E-5
|
2.513E-3
|
1.983E-2
|
1.231E-1
|
3
|
154
|
|
50
|
CID000167551
|
anacardic acid
|
Stitch
|
1.289E-4
|
3.880E-3
|
3.063E-2
|
1.940E-1
|
2
|
30
|
Show 45 more annotations
|
18: Disease [Display Chart]
13 input genes in category / 330 annotations before applied cutoff / 16205 genes in category
|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
C1850343
|
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME
|
DisGeNET Curated
|
8.055E-9
|
1.329E-6
|
8.477E-6
|
2.658E-6
|
3
|
6
|
|
2
|
C4023676
|
Increased nuchal translucency
|
DisGeNET Curated
|
8.055E-9
|
1.329E-6
|
8.477E-6
|
2.658E-6
|
3
|
6
|
|
3
|
C0003962
|
Ascites
|
DisGeNET Curated
|
5.320E-7
|
5.852E-5
|
3.732E-4
|
1.755E-4
|
3
|
21
|
|
4
|
C1864711
|
Muscle biopsy shows dystrophic changes
|
DisGeNET Curated
|
3.625E-6
|
2.501E-4
|
1.595E-3
|
1.196E-3
|
3
|
39
|
|
5
|
C4025846
|
Abnormality of vision
|
DisGeNET Curated
|
4.224E-6
|
2.501E-4
|
1.595E-3
|
1.394E-3
|
3
|
41
|
|
6
|
C0010964
|
Dandy-Walker Syndrome
|
DisGeNET Curated
|
4.547E-6
|
2.501E-4
|
1.595E-3
|
1.501E-3
|
3
|
42
|
|
7
|
C0521719
|
Clouding of corneal stroma
|
DisGeNET Curated
|
8.214E-6
|
3.385E-4
|
2.159E-3
|
2.711E-3
|
3
|
51
|
|
8
|
C1335177
|
Ovarian Serous Adenocarcinoma
|
DisGeNET BeFree
|
8.713E-6
|
3.385E-4
|
2.159E-3
|
2.875E-3
|
3
|
52
|
|
9
|
C0010038
|
Corneal Opacity
|
DisGeNET Curated
|
9.232E-6
|
3.385E-4
|
2.159E-3
|
3.047E-3
|
3
|
53
|
|
10
|
C1835884
|
Triangular face
|
DisGeNET Curated
|
1.213E-5
|
4.003E-4
|
2.553E-3
|
4.003E-3
|
3
|
58
|
|
11
|
C0020224
|
Polyhydramnios
|
DisGeNET Curated
|
3.835E-5
|
1.151E-3
|
7.338E-3
|
1.266E-2
|
3
|
85
|
|
12
|
C4280625
|
Decreased size of eyeball
|
DisGeNET Curated
|
5.693E-5
|
1.445E-3
|
9.217E-3
|
1.879E-2
|
3
|
97
|
|
13
|
C4280808
|
Abnormally small eyeball
|
DisGeNET Curated
|
5.693E-5
|
1.445E-3
|
9.217E-3
|
1.879E-2
|
3
|
97
|
|
14
|
C0334588
|
Giant Cell Glioblastoma
|
DisGeNET Curated
|
8.025E-5
|
1.892E-3
|
1.206E-2
|
2.648E-2
|
2
|
17
|
|
15
|
OMIN:114500
|
COLORECTAL CANCER; CRC
|
OMIM
|
1.764E-4
|
3.880E-3
|
2.475E-2
|
5.821E-2
|
2
|
25
|
|
16
|
C0280631
|
Leiomyosarcoma of uterus
|
DisGeNET Curated
|
3.093E-4
|
6.241E-3
|
3.980E-2
|
1.021E-1
|
2
|
33
|
|
17
|
C0026010
|
Microphthalmos
|
DisGeNET Curated
|
3.215E-4
|
6.241E-3
|
3.980E-2
|
1.061E-1
|
3
|
174
|
|
18
|
C0678230
|
Congenital Epicanthus
|
DisGeNET Curated
|
3.551E-4
|
6.511E-3
|
4.153E-2
|
1.172E-1
|
3
|
180
|
|
19
|
C0026850
|
Muscular Dystrophy
|
DisGeNET Curated
|
3.910E-4
|
6.780E-3
|
4.324E-2
|
1.290E-1
|
3
|
186
|
|
20
|
C1332225
|
Aggressive Non-Hodgkin Lymphoma
|
DisGeNET BeFree
|
4.109E-4
|
6.780E-3
|
4.324E-2
|
1.356E-1
|
2
|
38
|
|
21
|
C0021367
|
Mammary Ductal Carcinoma
|
DisGeNET BeFree
|
7.121E-4
|
8.273E-3
|
5.276E-2
|
2.350E-1
|
2
|
50
|
|
22
|
C1510497
|
Lens Opacities
|
DisGeNET Curated
|
7.450E-4
|
8.273E-3
|
5.276E-2
|
2.459E-1
|
3
|
232
|
|
23
|
OMIN:613615
|
SENIOR-LOKEN SYNDROME 7; SLSN7
|
OMIM
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
24
|
cv:C3150877
|
Senior-Loken syndrome 7
|
Clinical Variations
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
25
|
cv:C1864389
|
Premature chromatid separation trait
|
Clinical Variations
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
26
|
cv:C1858516
|
Primary autosomal recessive microcephaly 4
|
Clinical Variations
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
27
|
C3662259
|
Fetal anencephaly
|
DisGeNET BeFree
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
28
|
OMIN:176430
|
PREMATURE CHROMATID SEPARATION TRAIT; PCS
|
OMIM
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
29
|
C1850348
|
Hypodysplasia of the corpus callosum
|
DisGeNET Curated
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
30
|
cv:C1850343
|
Mosaic variegated aneuploidy syndrome
|
Clinical Variations
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
31
|
OMIN:257300
|
MOSAIC VARIEGATED ANEUPLOIDY SYNDROME; MVA
|
OMIM
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
32
|
cv:CN120370
|
Bardet-Biedl syndrome 16
|
Clinical Variations
|
8.022E-4
|
8.273E-3
|
5.276E-2
|
2.647E-1
|
1
|
1
|
|
33
|
C0022679
|
Cystic kidney
|
DisGeNET Curated
|
1.165E-3
|
1.165E-2
|
7.427E-2
|
3.843E-1
|
2
|
64
|
|
34
|
C1857130
|
Hypoplastic mandible condyle
|
DisGeNET Curated
|
1.232E-3
|
1.165E-2
|
7.428E-2
|
4.064E-1
|
3
|
276
|
|
35
|
C0025990
|
Micrognathism
|
DisGeNET Curated
|
1.271E-3
|
1.165E-2
|
7.428E-2
|
4.193E-1
|
3
|
279
|
|
36
|
C0240295
|
Mandibular hypoplasia
|
DisGeNET Curated
|
1.271E-3
|
1.165E-2
|
7.428E-2
|
4.193E-1
|
3
|
279
|
|
37
|
C0017601
|
Glaucoma
|
DisGeNET Curated
|
1.324E-3
|
1.181E-2
|
7.530E-2
|
4.368E-1
|
3
|
283
|
|
38
|
C1858516
|
MICROCEPHALY 4, PRIMARY, AUTOSOMAL RECESSIVE
|
DisGeNET Curated
|
1.604E-3
|
1.260E-2
|
8.037E-2
|
5.293E-1
|
1
|
2
|
|
39
|
C4021899
|
Premature chromatid separation
|
DisGeNET Curated
|
1.604E-3
|
1.260E-2
|
8.037E-2
|
5.293E-1
|
1
|
2
|
|
40
|
C0238141
|
Gingival Carcinoma
|
DisGeNET BeFree
|
1.604E-3
|
1.260E-2
|
8.037E-2
|
5.293E-1
|
1
|
2
|
|
41
|
C1864389
|
PREMATURE CHROMATID SEPARATION TRAIT
|
DisGeNET Curated
|
1.604E-3
|
1.260E-2
|
8.037E-2
|
5.293E-1
|
1
|
2
|
|
42
|
OMIN:604321
|
MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 4; MCPH4
|
OMIM
|
1.604E-3
|
1.260E-2
|
8.037E-2
|
5.293E-1
|
1
|
2
|
|
43
|
C3887499
|
Renal cyst
|
DisGeNET Curated
|
1.903E-3
|
1.427E-2
|
9.102E-2
|
6.279E-1
|
2
|
82
|
|
44
|
C0278704
|
Malignant Childhood Neoplasm
|
DisGeNET BeFree
|
1.903E-3
|
1.427E-2
|
9.102E-2
|
6.279E-1
|
2
|
82
|
|
45
|
C0260037
|
Multiple tumors
|
DisGeNET BeFree
|
2.043E-3
|
1.498E-2
|
9.554E-2
|
6.741E-1
|
2
|
85
|
|
46
|
C1527349
|
Ductal Breast Carcinoma
|
DisGeNET BeFree
|
2.237E-3
|
1.605E-2
|
1.023E-1
|
7.381E-1
|
2
|
89
|
|
47
|
C1559154
|
Rash and Dermatitis Adverse Event Associated with Chemoradiation
|
DisGeNET BeFree
|
2.337E-3
|
1.620E-2
|
1.033E-1
|
7.711E-1
|
2
|
91
|
|
48
|
C4277690
|
Ciliopathies
|
DisGeNET BeFree
|
2.388E-3
|
1.620E-2
|
1.033E-1
|
7.879E-1
|
2
|
92
|
|
49
|
C1855330
|
Cerebral hypoplasia
|
DisGeNET Curated
|
2.405E-3
|
1.620E-2
|
1.033E-1
|
7.936E-1
|
1
|
3
|
|
50
|
C0007138
|
Carcinoma, Transitional Cell
|
DisGeNET Curated
|
2.594E-3
|
1.712E-2
|
1.092E-1
|
8.559E-1
|
3
|
358
|
Show 45 more annotations
|
|