Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc280_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 30 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990450 linear polyubiquitin binding 3.215E-4 9.644E-3 3.853E-2 9.646E-3 1 1
2 GO:0070009 serine-type aminopeptidase activity 6.430E-4 9.644E-3 3.853E-2 1.929E-2 1 2
3 GO:0015057 thrombin-activated receptor activity 1.607E-3 1.607E-2
6.419E-2
 4.820E-2 1 5
4 GO:0070008 serine-type exopeptidase activity 6.094E-3 3.207E-2
1.281E-1
1.828E-1
 1 19
5 GO:0042975 peroxisome proliferator activated receptor binding 6.094E-3 3.207E-2
1.281E-1
1.828E-1
 1 19
6 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6.414E-3 3.207E-2
1.281E-1
1.924E-1
 1 20
Show 1 more annotation

2: GO: Biological Process [Display Chart] 6 input genes in category / 156 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007597 blood coagulation, intrinsic pathway 1.797E-8 2.804E-6 1.578E-5 2.804E-6 3 19
2 GO:0072378 blood coagulation, fibrin clot formation 4.818E-8 3.758E-6 2.116E-5 7.516E-6 3 26
3 GO:0072376 protein activation cascade 4.180E-6 2.173E-4 1.224E-3 6.520E-4 3 112
4 GO:0042730 fibrinolysis 3.025E-5 1.180E-3 6.643E-3 4.720E-3 2 27
5 GO:0030195 negative regulation of blood coagulation 1.095E-4 2.285E-3 1.286E-2 1.709E-2 2 51
6 GO:1900047 negative regulation of hemostasis 1.095E-4 2.285E-3 1.286E-2 1.709E-2 2 51
7 GO:0050819 negative regulation of coagulation 1.183E-4 2.285E-3 1.286E-2 1.846E-2 2 53
8 GO:0007596 blood coagulation 1.406E-4 2.285E-3 1.286E-2 2.194E-2 3 363
9 GO:0007599 hemostasis 1.464E-4 2.285E-3 1.286E-2 2.285E-2 3 368
10 GO:0050817 coagulation 1.464E-4 2.285E-3 1.286E-2 2.285E-2 3 368
11 GO:0061045 negative regulation of wound healing 1.729E-4 2.451E-3 1.380E-2 2.697E-2 2 64
12 GO:1902532 negative regulation of intracellular signal transduction 3.413E-4 3.874E-3 2.181E-2
5.324E-2
 3 490
13 GO:1900046 regulation of hemostasis 3.575E-4 3.874E-3 2.181E-2
5.577E-2
 2 92
14 GO:0030193 regulation of blood coagulation 3.575E-4 3.874E-3 2.181E-2
5.577E-2
 2 92
15 GO:0050818 regulation of coagulation 3.892E-4 3.874E-3 2.181E-2
6.071E-2
 2 96
16 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 3.973E-4 3.874E-3 2.181E-2
6.198E-2
 2 97
17 GO:0061041 regulation of wound healing 7.790E-4 7.149E-3 4.025E-2
1.215E-1
 2 136
18 GO:2001242 regulation of intrinsic apoptotic signaling pathway 1.076E-3 9.323E-3
5.249E-2
1.678E-1
 2 160
19 GO:0030168 platelet activation 1.185E-3 9.729E-3
5.478E-2
1.849E-1
 2 168
20 GO:0051919 positive regulation of fibrinolysis 1.288E-3 1.005E-2
5.657E-2
2.010E-1
 1 4
21 GO:1903035 negative regulation of response to wounding 1.434E-3 1.065E-2
5.998E-2
2.237E-1
 2 185
22 GO:2001234 negative regulation of apoptotic signaling pathway 2.167E-3 1.537E-2
8.652E-2
3.381E-1
 2 228
23 GO:0097341 zymogen inhibition 3.218E-3 2.008E-2
1.131E-1
5.020E-1
 1 10
24 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process 3.218E-3 2.008E-2
1.131E-1
5.020E-1
 1 10
25 GO:0097340 inhibition of cysteine-type endopeptidase activity 3.218E-3 2.008E-2
1.131E-1
5.020E-1
 1 10
26 GO:0070493 thrombin-activated receptor signaling pathway 3.539E-3 2.045E-2
1.151E-1
5.521E-1
 1 11
27 GO:2000773 negative regulation of cellular senescence 3.539E-3 2.045E-2
1.151E-1
5.521E-1
 1 11
28 GO:0097193 intrinsic apoptotic signaling pathway 3.741E-3 2.085E-2
1.174E-1
5.837E-1
 2 301
29 GO:0032102 negative regulation of response to external stimulus 4.141E-3 2.174E-2
1.224E-1
6.460E-1
 2 317
30 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.182E-3 2.174E-2
1.224E-1
6.523E-1
 1 13
31 GO:0051917 regulation of fibrinolysis 4.503E-3 2.266E-2
1.276E-1
7.024E-1
 1 14
32 GO:0016485 protein processing 4.694E-3 2.289E-2
1.289E-1
7.323E-1
 2 338
33 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5.145E-3 2.432E-2
1.369E-1
8.025E-1
 1 16
34 GO:0090344 negative regulation of cell aging 5.465E-3 2.444E-2
1.376E-1
8.526E-1
 1 17
35 GO:0051604 protein maturation 5.483E-3 2.444E-2
1.376E-1
8.554E-1
 2 366
36 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 6.427E-3 2.710E-2
1.526E-1
1.000E0
 1 20
37 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 6.427E-3 2.710E-2
1.526E-1
1.000E0
 1 20
38 GO:0031639 plasminogen activation 6.748E-3 2.723E-2
1.533E-1
1.000E0
 1 21
39 GO:2001233 regulation of apoptotic signaling pathway 6.807E-3 2.723E-2
1.533E-1
1.000E0
 2 409
40 GO:0007250 activation of NF-kappaB-inducing kinase activity 7.068E-3 2.757E-2
1.552E-1
1.000E0
 1 22
41 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 8.669E-3 3.145E-2
1.771E-1
1.000E0
 1 27
42 GO:0035666 TRIF-dependent toll-like receptor signaling pathway 8.669E-3 3.145E-2
1.771E-1
1.000E0
 1 27
43 GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator 8.669E-3 3.145E-2
1.771E-1
1.000E0
 1 27
44 GO:1903034 regulation of response to wounding 8.987E-3 3.186E-2
1.794E-1
1.000E0
 2 472
45 GO:2000772 regulation of cellular senescence 9.308E-3 3.227E-2
1.817E-1
1.000E0
 1 29
46 GO:1901797 negative regulation of signal transduction by p53 class mediator 9.628E-3 3.265E-2
1.838E-1
1.000E0
 1 30
47 GO:0002756 MyD88-independent toll-like receptor signaling pathway 9.948E-3 3.302E-2
1.859E-1
1.000E0
 1 31
48 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 1.027E-2 3.337E-2
1.879E-1
1.000E0
 1 32
49 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1.059E-2 3.370E-2
1.898E-1
1.000E0
 1 33
50 GO:0090342 regulation of cell aging 1.154E-2 3.421E-2
1.926E-1
1.000E0
 1 36
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 16 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008385 IkappaB kinase complex 3.458E-3 4.851E-2
1.640E-1
5.533E-2
 1 11
2 GO:0031362 anchored component of external side of plasma membrane 7.219E-3 4.851E-2
1.640E-1
1.155E-1
 1 23
3 GO:0031233 intrinsic component of external side of plasma membrane 9.095E-3 4.851E-2
1.640E-1
1.455E-1
 1 29

4: Human Phenotype [Display Chart] 4 input genes in category / 522 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000132 Menorrhagia 1.932E-6 1.008E-3 6.893E-3 1.008E-3 3 38
2 HP:0006298 Prolonged bleeding after dental extraction 5.413E-6 1.413E-3 9.657E-3 2.825E-3 2 5
3 HP:0003010 Prolonged bleeding time 1.142E-5 1.987E-3 1.358E-2 5.962E-3 3 68
4 HP:0003454 Platelet antibody positive 2.432E-5 2.692E-3 1.840E-2 1.270E-2 2 10
5 HP:0011890 Prolonged bleeding following procedure 3.565E-5 2.692E-3 1.840E-2 1.861E-2 2 12
6 HP:0011878 Abnormal platelet membrane protein expression 4.212E-5 2.692E-3 1.840E-2 2.199E-2 2 13
7 HP:0004807 Thrombasthenia 4.212E-5 2.692E-3 1.840E-2 2.199E-2 2 13
8 HP:0001975 Decreased platelet glycoprotein IIb-IIIa 4.212E-5 2.692E-3 1.840E-2 2.199E-2 2 13
9 HP:0001934 Persistent bleeding after trauma 4.913E-5 2.692E-3 1.840E-2 2.565E-2 2 14
10 HP:0000421 Epistaxis 5.157E-5 2.692E-3 1.840E-2 2.692E-2 3 112
11 HP:0001902 Giant platelets 7.336E-5 3.481E-3 2.380E-2 3.830E-2 2 17
12 HP:0011875 Abnormal platelet morphology 1.888E-4 8.213E-3
5.614E-2
9.856E-2
 2 27
13 HP:0011877 Increased mean platelet volume 2.338E-4 9.387E-3
6.417E-2
1.220E-1
 2 30
14 HP:0011876 Abnormal platelet volume 2.835E-4 1.057E-2
7.227E-2
1.480E-1
 2 33
15 HP:0002277 Horner syndrome 3.770E-4 1.284E-2
8.774E-2
1.968E-1
 2 38
16 HP:0003540 Impaired platelet aggregation 4.180E-4 1.284E-2
8.774E-2
2.182E-1
 2 40
17 HP:0030402 Abnormal platelet aggregation 4.180E-4 1.284E-2
8.774E-2
2.182E-1
 2 40
18 HP:0000616 Miosis 6.812E-4 1.932E-2
1.321E-1
3.556E-1
 2 51
19 HP:0007535 Hypopigmented streaks 8.498E-4 1.932E-2
1.321E-1
4.436E-1
 1 1
20 HP:0007850 Retinal vascular proliferation 8.498E-4 1.932E-2
1.321E-1
4.436E-1
 1 1
21 HP:0007572 Hyperpigmented streaks 8.498E-4 1.932E-2
1.321E-1
4.436E-1
 1 1
22 HP:0004529 Atrophic, patchy alopecia 8.498E-4 1.932E-2
1.321E-1
4.436E-1
 1 1
23 HP:0011869 Abnormal platelet function 8.512E-4 1.932E-2
1.321E-1
4.443E-1
 2 57
24 HP:0007686 Abnormal pupillary function 1.007E-3 2.190E-2
1.497E-1
5.257E-1
 2 62
25 HP:0003346 Abnormal immunological laboratory finding 1.295E-3 2.705E-2
1.849E-1
6.762E-1
 3 330
26 HP:0011275 Recurrent mycobacterium avium complex infections 1.699E-3 3.411E-2
2.332E-1
8.869E-1
 1 2
27 HP:0011029 Internal hemorrhage 2.010E-3 3.886E-2
2.656E-1
1.000E0
 3 383
28 HP:0030057 Autoimmune antibody positivity 2.258E-3 4.210E-2
2.878E-1
1.000E0
 2 93
29 HP:0002847 Impaired memory B cell generation 2.548E-3 4.433E-2
3.030E-1
1.000E0
 1 3
30 HP:0007546 Linear hyperpigmentation 2.548E-3 4.433E-2
3.030E-1
1.000E0
 1 3
31 HP:0000615 Abnormal pupil morphology 2.818E-3 4.746E-2
3.244E-1
1.000E0
 2 104
Show 26 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 286 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005606 increased bleeding time 1.288E-5 3.685E-3 2.297E-2 3.685E-3 3 91
2 MP:0004566 myocardial fiber degeneration 1.949E-4 2.060E-2
1.285E-1
5.574E-2
 2 38
3 MP:0003888 liver hemorrhage 2.161E-4 2.060E-2
1.285E-1
6.181E-2
 2 40
4 MP:0002551 abnormal blood coagulation 3.721E-4 2.174E-2
1.355E-1
1.064E-1
 3 281
5 MP:0009676 abnormal hemostasis 3.800E-4 2.174E-2
1.355E-1
1.087E-1
 3 283
6 MP:0003333 liver fibrosis 7.220E-4 3.031E-2
1.890E-1
2.065E-1
 2 73
7 MP:0002599 increased mean platelet volume 7.419E-4 3.031E-2
1.890E-1
2.122E-1
 2 74
8 MP:0001654 hepatic necrosis 1.324E-3 3.896E-2
2.429E-1
3.786E-1
 2 99
9 MP:0002586 abnormal platelet volume 1.544E-3 3.896E-2
2.429E-1
4.417E-1
 2 107
10 MP:0002417 abnormal megakaryocyte morphology 1.631E-3 3.896E-2
2.429E-1
4.666E-1
 2 110
11 MP:0013660 abnormal bone marrow hematopoietic cell morphology 1.906E-3 3.896E-2
2.429E-1
5.451E-1
 2 119
12 MP:0005048 abnormal thrombosis 2.002E-3 3.896E-2
2.429E-1
5.726E-1
 2 122
13 MP:0008253 absent megakaryocytes 2.316E-3 3.896E-2
2.429E-1
6.624E-1
 1 4
14 MP:0011009 increased circulating glutamate dehydrogenase level 2.316E-3 3.896E-2
2.429E-1
6.624E-1
 1 4
15 MP:0003454 erythroderma 2.316E-3 3.896E-2
2.429E-1
6.624E-1
 1 4
16 MP:0011008 abnormal circulating glutamate dehydrogenase level 2.316E-3 3.896E-2
2.429E-1
6.624E-1
 1 4
17 MP:0011144 thin lung-associated mesenchyme 2.316E-3 3.896E-2
2.429E-1
6.624E-1
 1 4
Show 12 more annotations

6: Domain [Display Chart] 6 input genes in category / 50 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01462 LRRNT Pfam 1.169E-4 3.202E-3 1.441E-2 5.847E-3 2 53
2 SM00082 LRRCT SMART 3.381E-4 3.202E-3 1.441E-2 1.690E-2 2 90
3 IPR000483 Cys-rich flank reg C InterPro 3.381E-4 3.202E-3 1.441E-2 1.690E-2 2 90
4 IPR000372 LRRNT InterPro 4.007E-4 3.202E-3 1.441E-2 2.004E-2 2 98
5 SM00013 LRRNT SMART 4.007E-4 3.202E-3 1.441E-2 2.004E-2 2 98
6 IPR000177 Apple InterPro 6.404E-4 3.202E-3 1.441E-2 3.202E-2 1 2
7 SM00223 APPLE SMART 6.404E-4 3.202E-3 1.441E-2 3.202E-2 1 2
8 PF11577 NEMO Pfam 6.404E-4 3.202E-3 1.441E-2 3.202E-2 1 2
9 PS00495 APPLE PROSITE 6.404E-4 3.202E-3 1.441E-2 3.202E-2 1 2
10 IPR021063 NEMO N InterPro 6.404E-4 3.202E-3 1.441E-2 3.202E-2 1 2
11 IPR032419 CC2-LZ dom InterPro 9.605E-4 3.202E-3 1.441E-2 4.803E-2 1 3
12 PF16516 CC2-LZ Pfam 9.605E-4 3.202E-3 1.441E-2 4.803E-2 1 3
13 IPR021537 HIF alpha subunit InterPro 9.605E-4 3.202E-3 1.441E-2 4.803E-2 1 3
14 PS51801 ZF CCHC NOA PROSITE 9.605E-4 3.202E-3 1.441E-2 4.803E-2 1 3
15 PF11413 HIF-1 Pfam 9.605E-4 3.202E-3 1.441E-2 4.803E-2 1 3
16 IPR003609 Pan app InterPro 2.240E-3 6.222E-3 2.800E-2
1.120E-1
 1 7
17 PF00024 PAN 1 Pfam 2.240E-3 6.222E-3 2.800E-2
1.120E-1
 1 7
18 PS50948 PAN PROSITE 2.240E-3 6.222E-3 2.800E-2
1.120E-1
 1 7
19 PS01258 BH2 PROSITE 4.157E-3 1.042E-2 4.687E-2
2.078E-1
 1 13
20 3.80.10.10 - Gene3D 4.194E-3 1.042E-2 4.687E-2
2.097E-1
 2 321
21 IPR032675 L dom-like InterPro 4.375E-3 1.042E-2 4.687E-2
2.188E-1
 2 328
22 PF08447 PAS 3 Pfam 7.344E-3 1.537E-2
6.915E-2
3.672E-1
 1 23
23 IPR013655 PAS fold 3 InterPro 7.344E-3 1.537E-2
6.915E-2
3.672E-1
 1 23
24 IPR013767 PAS fold InterPro 7.981E-3 1.537E-2
6.915E-2
3.990E-1
 1 25
25 PF00989 PAS Pfam 7.981E-3 1.537E-2
6.915E-2
3.990E-1
 1 25
26 IPR001610 PAC InterPro 8.299E-3 1.537E-2
6.915E-2
4.149E-1
 1 26
27 SM00086 PAC SMART 8.299E-3 1.537E-2
6.915E-2
4.149E-1
 1 26
28 PF01463 LRRCT Pfam 1.021E-2 1.749E-2
7.867E-2
5.103E-1
 1 32
29 SM00091 PAS SMART 1.021E-2 1.749E-2
7.867E-2
5.103E-1
 1 32
30 PS50112 PAS PROSITE 1.084E-2 1.749E-2
7.867E-2
5.420E-1
 1 34
31 IPR000014 PAS InterPro 1.084E-2 1.749E-2
7.867E-2
5.420E-1
 1 34
32 IPR009053 Prefoldin InterPro 2.284E-2 3.569E-2
1.606E-1
1.000E0
 1 72
33 IPR033116 TRYPSIN SER InterPro 2.848E-2 4.306E-2
1.937E-1
1.000E0
 1 90
34 IPR018114 TRYPSIN HIS InterPro 3.254E-2 4.306E-2
1.937E-1
1.000E0
 1 103
35 PS00135 TRYPSIN SER PROSITE 3.347E-2 4.306E-2
1.937E-1
1.000E0
 1 106
36 PS00134 TRYPSIN HIS PROSITE 3.379E-2 4.306E-2
1.937E-1
1.000E0
 1 107
37 IPR001314 Peptidase S1A InterPro 3.565E-2 4.306E-2
1.937E-1
1.000E0
 1 113
38 PS50240 TRYPSIN DOM PROSITE 3.627E-2 4.306E-2
1.937E-1
1.000E0
 1 115
39 SM00020 Tryp SPc SMART 3.689E-2 4.306E-2
1.937E-1
1.000E0
 1 117
40 SM00353 HLH SMART 3.689E-2 4.306E-2
1.937E-1
1.000E0
 1 117
41 PS50888 BHLH PROSITE 3.721E-2 4.306E-2
1.937E-1
1.000E0
 1 118
42 IPR011598 bHLH dom InterPro 3.752E-2 4.306E-2
1.937E-1
1.000E0
 1 119
43 IPR001254 Trypsin dom InterPro 3.814E-2 4.306E-2
1.937E-1
1.000E0
 1 121
44 PF00089 Trypsin Pfam 3.814E-2 4.306E-2
1.937E-1
1.000E0
 1 121
45 IPR009003 Peptidase S1 PA InterPro 3.876E-2 4.306E-2
1.937E-1
1.000E0
 1 123
Show 40 more annotations

7: Pathway [Display Chart] 5 input genes in category / 163 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269370 Intrinsic Pathway of Fibrin Clot Formation BioSystems: REACTOME 4.778E-8 7.789E-6 4.419E-5 7.789E-6 3 22
2 1269368 Formation of Fibrin Clot (Clotting Cascade) BioSystems: REACTOME 2.830E-7 2.306E-5 1.309E-4 4.613E-5 3 39
3 PW:0000508 platelet aggregation Pathway Ontology 1.934E-6 1.051E-4 5.963E-4 3.153E-4 2 6
4 1269351 GP1b-IX-V activation signalling BioSystems: REACTOME 5.799E-6 2.363E-4 1.341E-3 9.453E-4 2 10
5 1269349 Platelet Adhesion to exposed collagen BioSystems: REACTOME 1.005E-5 3.275E-4 1.858E-3 1.638E-3 2 13
6 1269358 Platelet Aggregation (Plug Formation) BioSystems: REACTOME 9.019E-5 2.329E-3 1.322E-2 1.470E-2 2 38
7 P00011 Blood coagulation PantherDB 1.000E-4 2.329E-3 1.322E-2 1.631E-2 2 40
8 83068 ECM-receptor interaction BioSystems: KEGG 4.231E-4 8.620E-3 4.891E-2
6.896E-2
 2 82
9 83078 Hematopoietic cell lineage BioSystems: KEGG 5.917E-4 1.072E-2
6.080E-2
9.645E-2
 2 97
10 1269167 IKBKB deficiency causes SCID BioSystems: REACTOME 8.031E-4 1.309E-2
7.427E-2
1.309E-1
 1 2
11 952858 Platelet activation BioSystems: KEGG 9.495E-4 1.407E-2
7.983E-2
1.548E-1
 2 123
12 1269168 IkBA variant leads to EDA-ID BioSystems: REACTOME 2.809E-3 2.448E-2
1.389E-1
4.578E-1
 1 7
13 1269166 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) BioSystems: REACTOME 3.209E-3 2.448E-2
1.389E-1
5.231E-1
 1 8
14 PW:0000474 coagulation cascade Pathway Ontology 3.610E-3 2.448E-2
1.389E-1
5.884E-1
 1 9
15 1269208 IRAK1 recruits IKK complex BioSystems: REACTOME 4.411E-3 2.448E-2
1.389E-1
7.189E-1
 1 11
16 1269230 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation BioSystems: REACTOME 4.411E-3 2.448E-2
1.389E-1
7.189E-1
 1 11
17 PW:0000233 tumor necrosis factor mediated signaling Pathway Ontology 4.811E-3 2.448E-2
1.389E-1
7.842E-1
 1 12
18 1270419 Regulation of gene expression by Hypoxia-inducible Factor BioSystems: REACTOME 4.811E-3 2.448E-2
1.389E-1
7.842E-1
 1 12
19 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 4.887E-3 2.448E-2
1.389E-1
7.965E-1
 2 282
20 1269261 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 BioSystems: REACTOME 5.211E-3 2.448E-2
1.389E-1
8.494E-1
 1 13
21 PW:0000499 Nuclear Factor Kappa B signaling Pathway Ontology 5.211E-3 2.448E-2
1.389E-1
8.494E-1
 1 13
22 M6487 Platelet Amyloid Precursor Protein Pathway MSigDB C2 BIOCARTA (v6.0) 5.611E-3 2.448E-2
1.389E-1
9.146E-1
 1 14
23 138056 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha BioSystems: Pathway Interaction Database 6.011E-3 2.448E-2
1.389E-1
9.797E-1
 1 15
24 M16697 CD40L Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 6.011E-3 2.448E-2
1.389E-1
9.797E-1
 1 15
25 1309122 MAP3K8 (TPL2)-dependent MAPK1/3 activation BioSystems: REACTOME 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
26 SMP00288 Aprotinin Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
27 SMP00282 Streptokinase Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
28 SMP00284 Urokinase Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
29 SMP00287 Tranexamic Acid Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
30 SMP00283 Tenecteplase Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
31 M10183 Acetylation and Deacetylation of RelA in The Nucleus MSigDB C2 BIOCARTA (v6.0) 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
32 SMP00281 Anistreplase Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
33 SMP00286 Aminocaproic Acid Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
34 SMP00285 Reteplase Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
35 SMP00280 Alteplase Pathway SMPDB 6.410E-3 2.448E-2
1.389E-1
1.000E0
 1 16
36 SMP00279 Ximelagatran Pathway SMPDB 6.810E-3 2.448E-2
1.389E-1
1.000E0
 1 17
37 SMP00276 Argatroban Pathway SMPDB 6.810E-3 2.448E-2
1.389E-1
1.000E0
 1 17
38 SMP00277 Bivalirudin Pathway SMPDB 6.810E-3 2.448E-2
1.389E-1
1.000E0
 1 17
39 SMP00278 Lepirudin Pathway SMPDB 6.810E-3 2.448E-2
1.389E-1
1.000E0
 1 17
40 SMP00275 Ardeparin Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
41 SMP00274 Heparin Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
42 SMP00271 Phenprocoumon Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
43 SMP00272 Enoxaparin Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
44 SMP00270 Dicumarol Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
45 SMP00268 Warfarin Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
46 M10082 TNFR2 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
47 SMP00269 Acenocoumarol Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
48 SMP00273 Fondaparinux Pathway SMPDB 7.209E-3 2.448E-2
1.389E-1
1.000E0
 1 18
49 1269212 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 BioSystems: REACTOME 7.608E-3 2.531E-2
1.436E-1
1.000E0
 1 19
50 1269213 activated TAK1 mediates p38 MAPK activation BioSystems: REACTOME 8.008E-3 2.610E-2
1.481E-1
1.000E0
 1 20
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1398 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12522011 Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
2 27148783 Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
3 15317813 Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
4 15375170 Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
5 17095718 Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
6 17597992 A short history of platelet glycoprotein Ib complex. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
7 3353370 The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence. Pubmed 2.057E-8 3.920E-6 3.066E-5 2.875E-5 2 2
8 18789323 Juxtamembrane basic residues in glycoprotein Ibbeta cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
9 18674540 Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
10 7690959 Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
11 21699652 Molecular basis of Bernard-Soulier syndrome in 27 patients from India. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
12 12463594 Genetic abnormalities of Bernard-Soulier syndrome. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
13 11943773 Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
14 24051142 Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
15 12693941 A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
16 28148841 Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
17 12968031 Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
18 17922811 Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
19 19808696 Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
20 9454760 Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
21 23995613 Novel genetic abnormalities in Bernard-Soulier syndrome in India. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
22 10627461 Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V. Pubmed 6.170E-8 3.920E-6 3.066E-5 8.625E-5 2 3
23 23929303 Bernard-Soulier syndrome: an update. Pubmed 1.234E-7 6.160E-6 4.818E-5 1.725E-4 2 4
24 21507943 Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shear. Pubmed 1.234E-7 6.160E-6 4.818E-5 1.725E-4 2 4
25 2557900 Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex. Pubmed 1.234E-7 6.160E-6 4.818E-5 1.725E-4 2 4
26 9425086 Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. Pubmed 1.234E-7 6.160E-6 4.818E-5 1.725E-4 2 4
27 27834869 MicroRNAs 10a and 10b Regulate the Expression of Human Platelet Glycoprotein Ibα for Normal Megakaryopoiesis. Pubmed 1.234E-7 6.160E-6 4.818E-5 1.725E-4 2 4
28 8608228 Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. Pubmed 1.234E-7 6.160E-6 4.818E-5 1.725E-4 2 4
29 21037087 Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Pubmed 2.056E-7 8.711E-6 6.812E-5 2.875E-4 2 5
30 10887121 Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta. Pubmed 2.056E-7 8.711E-6 6.812E-5 2.875E-4 2 5
31 15477207 Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. Pubmed 2.056E-7 8.711E-6 6.812E-5 2.875E-4 2 5
32 11812775 Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3. Pubmed 2.056E-7 8.711E-6 6.812E-5 2.875E-4 2 5
33 12855811 Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Pubmed 2.056E-7 8.711E-6 6.812E-5 2.875E-4 2 5
34 21529934 Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin. Pubmed 3.084E-7 1.198E-5 9.366E-5 4.312E-4 2 6
35 20667040 The allele frequencies of HPA 1-16 determined by PCR-SSP in Chinese Cantonese donors. Pubmed 3.084E-7 1.198E-5 9.366E-5 4.312E-4 2 6
36 19570064 Simultaneous genotyping of human platelet antigen-1 to 17w by polymerase chain reaction sequence-based typing. Pubmed 3.084E-7 1.198E-5 9.366E-5 4.312E-4 2 6
37 1939645 von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. Pubmed 4.318E-7 1.631E-5 1.276E-4 6.036E-4 2 7
38 10429193 A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. Pubmed 5.756E-7 2.118E-5 1.656E-4 8.047E-4 2 8
39 8467233 Platelet alpha-granules. Pubmed 7.400E-7 2.653E-5 2.075E-4 1.035E-3 2 9
40 10391209 Characterization of single-nucleotide polymorphisms in coding regions of human genes. Pubmed 4.527E-5 4.980E-4 3.895E-3
6.328E-2
 2 67
41 22176836 NEMO expression in human hepatocellular carcinoma and its association with clinical outcome. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
42 23305485 Genetic analysis in FXI deficient patients from northwestern Italy: three novel and one recurrent mutation. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
43 22704541 Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
44 27006387 A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
45 2070794 Identification of the disulphide bonds in human platelet glycocalicin. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
46 15107419 The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
47 2628181 The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
48 18769159 What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
49 11167769 Genetic linkage of Kozak sequence polymorphism of the platelet glycoprotein Ib alpha with human platelet antigen-2 and variable number of tandem repeats polymorphism, and its relationship with coronary artery disease. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
50 28961024 Gene of the issue: GP1BA gene mutations associated with bleeding. Pubmed 1.571E-4 4.980E-4 3.895E-3
2.196E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 407 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GP9 GP9 interactions 1.435E-6 5.841E-4 3.848E-3 5.841E-4 2 6
2 int:GP1BA GP1BA interactions 1.299E-5 2.643E-3 1.741E-2 5.287E-3 2 17
3 int:GP1BB GP1BB interactions 6.342E-5 8.604E-3
5.668E-2
 2.581E-2 2 37
4 int:F2 F2 interactions 8.999E-5 8.729E-3
5.750E-2
 3.663E-2 2 44
5 int:KNG1 KNG1 interactions 1.072E-4 8.729E-3
5.750E-2
 4.365E-2 2 48
6 int:DDIT3 DDIT3 interactions 2.915E-4 1.978E-2
1.303E-1
1.187E-1
 2 79
7 int:NRARP NRARP interactions 6.778E-4 3.034E-2
1.999E-1
2.758E-1
 1 2
8 int:EPAS1 EPAS1 interactions 6.939E-4 3.034E-2
1.999E-1
2.824E-1
 2 122
9 int:PADI2 PADI2 interactions 1.016E-3 3.034E-2
1.999E-1
4.137E-1
 1 3
10 int:C19orf12 C19orf12 interactions 1.016E-3 3.034E-2
1.999E-1
4.137E-1
 1 3
11 int:BCL2L1 BCL2L1 interactions 1.234E-3 3.034E-2
1.999E-1
5.021E-1
 2 163
12 int:KIR3DX1 KIR3DX1 interactions 1.355E-3 3.034E-2
1.999E-1
5.515E-1
 1 4
13 int:GP5 GP5 interactions 1.355E-3 3.034E-2
1.999E-1
5.515E-1
 1 4
14 int:MAFIP MAFIP interactions 1.355E-3 3.034E-2
1.999E-1
5.515E-1
 1 4
15 int:TCP11 TCP11 interactions 1.355E-3 3.034E-2
1.999E-1
5.515E-1
 1 4
16 int:MYL5 MYL5 interactions 1.355E-3 3.034E-2
1.999E-1
5.515E-1
 1 4
17 int:ACBD6 ACBD6 interactions 1.355E-3 3.034E-2
1.999E-1
5.515E-1
 1 4
18 int:ARNT ARNT interactions 1.404E-3 3.034E-2
1.999E-1
5.714E-1
 2 174
19 int:KPNA7 KPNA7 interactions 1.694E-3 3.034E-2
1.999E-1
6.893E-1
 1 5
20 int:ODAM ODAM interactions 2.032E-3 3.034E-2
1.999E-1
8.271E-1
 1 6
21 int:ANGPTL8 ANGPTL8 interactions 2.032E-3 3.034E-2
1.999E-1
8.271E-1
 1 6
22 int:TFPI2 TFPI2 interactions 2.032E-3 3.034E-2
1.999E-1
8.271E-1
 1 6
23 int:HPD HPD interactions 2.370E-3 3.034E-2
1.999E-1
9.648E-1
 1 7
24 int:PNMA8A PNMA8A interactions 2.370E-3 3.034E-2
1.999E-1
9.648E-1
 1 7
25 int:LYN LYN interactions 2.478E-3 3.034E-2
1.999E-1
1.000E0
 2 232
26 int:FRMD8 FRMD8 interactions 2.709E-3 3.034E-2
1.999E-1
1.000E0
 1 8
27 int:NECAB3 NECAB3 interactions 2.709E-3 3.034E-2
1.999E-1
1.000E0
 1 8
28 int:GRK4 GRK4 interactions 2.709E-3 3.034E-2
1.999E-1
1.000E0
 1 8
29 int:NFKBIZ NFKBIZ interactions 2.709E-3 3.034E-2
1.999E-1
1.000E0
 1 8
30 int:TRIM40 TRIM40 interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
31 int:BCL2L12 BCL2L12 interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
32 int:TSLP TSLP interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
33 int:ARPP19 ARPP19 interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
34 int:RPL41 RPL41 interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
35 int:ROS1 ROS1 interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
36 int:AMY2A AMY2A interactions 3.047E-3 3.034E-2
1.999E-1
1.000E0
 1 9
37 int:CNTN2 CNTN2 interactions 3.385E-3 3.034E-2
1.999E-1
1.000E0
 1 10
38 int:NKX3-2 NKX3-2 interactions 3.385E-3 3.034E-2
1.999E-1
1.000E0
 1 10
39 int:LGALS2 LGALS2 interactions 3.385E-3 3.034E-2
1.999E-1
1.000E0
 1 10
40 int:LMCD1 LMCD1 interactions 3.385E-3 3.034E-2
1.999E-1
1.000E0
 1 10
41 int:F11 F11 interactions 3.723E-3 3.034E-2
1.999E-1
1.000E0
 1 11
42 int:CALB1 CALB1 interactions 3.723E-3 3.034E-2
1.999E-1
1.000E0
 1 11
43 int:SELP SELP interactions 3.723E-3 3.034E-2
1.999E-1
1.000E0
 1 11
44 int:AVPI1 AVPI1 interactions 3.723E-3 3.034E-2
1.999E-1
1.000E0
 1 11
45 int:RUBCN RUBCN interactions 3.723E-3 3.034E-2
1.999E-1
1.000E0
 1 11
46 int:AMMECR1L AMMECR1L interactions 4.061E-3 3.034E-2
1.999E-1
1.000E0
 1 12
47 int:ADAP2 ADAP2 interactions 4.061E-3 3.034E-2
1.999E-1
1.000E0
 1 12
48 int:HIF3A HIF3A interactions 4.061E-3 3.034E-2
1.999E-1
1.000E0
 1 12
49 int:INHA INHA interactions 4.061E-3 3.034E-2
1.999E-1
1.000E0
 1 12
50 int:LZIC LZIC interactions 4.061E-3 3.034E-2
1.999E-1
1.000E0
 1 12
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q35 4q35 2.306E-3 1.153E-2 2.633E-2 1.153E-2 1 16
2 19q13.32 19q13.32 1.134E-2 2.010E-2 4.589E-2
5.672E-2
 1 79
3 19q13.3 19q13.3 1.206E-2 2.010E-2 4.589E-2
6.030E-2
 1 84
4 22q11.21 22q11.21 1.748E-2 2.185E-2 4.988E-2
8.738E-2
 1 122
5 Xq28 Xq28 2.768E-2 2.768E-2
6.319E-2
1.384E-1
 1 194

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 17 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1057 BCL2 family genenames.org 3.842E-3 5.973E-3 1.244E-2 1.537E-2 1 14
2 66 Zinc fingers|Zinc fingers C2HC-type genenames.org 4.390E-3 5.973E-3 1.244E-2 1.756E-2 1 16
3 471 CD molecules|Tumor necrosis factor superfamily genenames.org 4.480E-3 5.973E-3 1.244E-2 1.792E-2 2 394
4 420 Basic helix-loop-helix proteins genenames.org 2.987E-2 2.987E-2
6.223E-2
1.195E-1
 1 110

13: Coexpression [Display Chart] 6 input genes in category / 348 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5946 Genes encoding components of blood coagulation system; also up-regulated in platelets. MSigDB H: Hallmark Gene Sets (v6.0) 5.215E-4 2.231E-2
1.435E-1
1.815E-1
 2 138
2 15980968-Table3b Human Brain Bandres05 182genes GeneSigDB 6.488E-4 2.231E-2
1.435E-1
2.258E-1
 2 154
3 M9556 Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.087E-4 2.231E-2
1.435E-1
2.466E-1
 2 161
4 M2640 Genes down-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 24h. MSigDB C6: Oncogenic Signatures (v6.0) 8.845E-4 2.231E-2
1.435E-1
3.078E-1
 2 180
5 12738660-TableS3 Human Leukemia Yagi03 213genes GeneSigDB 9.744E-4 2.231E-2
1.435E-1
3.391E-1
 2 189
6 M8283 Genes down-regulated in thymic memory like CD8 cells: wildtype versus KFL13 [GeneID=51621] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.016E-3 2.231E-2
1.435E-1
3.535E-1
 2 193
7 M4722 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.037E-3 2.231E-2
1.435E-1
3.608E-1
 2 195
8 M4985 Genes up-regulated in comparison of B cells from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.231E-2
1.435E-1
3.719E-1
 2 198
9 M5163 Genes down-regulated in comparison of macrophages versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.231E-2
1.435E-1
3.756E-1
 2 199
10 M3687 Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with LPS (TLR4 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
11 M6630 Genes down-regulated in bone marrow-derived macrophages with IL10 [GeneID=3486] knockout and 45 min of stimulation by: LPS versus LPS and IL10 [GeneID=3486]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
12 M9608 Genes up-regulated in CD42 low [GeneID=100133941] cells from thymus: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
13 M3132 Genes down-regulated in comparison of untreated macrophages versus those cultured with M-CSF [GeneID=1435], IFNG [GeneID=3458] and Pam3Cys (TLR2 agonist). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
14 M4884 Genes up-regulated in comparison of naive follicular B cells versus early germinal center (GC) B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
15 M6375 Genes up-regulated in B lymphocytes: naïve versus germinal center. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
16 M9164 Genes up-regulated in CD4 T conv over-expressing GATA1 [GeneID=2623] versus GATA1 and FOX3P [GeneID=2623;50943]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
17 M9696 Genes up-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 10h versus 30h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.231E-2
1.435E-1
3.793E-1
 2 200
18 M2213 Genes down-regulated in CD34+ [GeneID=947] cells by intermediate activity levels of STAT5A [GeneID=6776]; predominant long-term growth and self-renewal phenotype. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.235E-3 2.387E-2
1.535E-1
4.297E-1
 2 213
19 M2885 Genes down-regulated in epithelial lung and breast cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 2.226E-3 4.076E-2
2.621E-1
7.745E-1
 2 287
20 16584549-Table2 Human Colon Xi06 11genes GeneSigDB 2.849E-3 4.882E-2
3.140E-1
9.916E-1
 1 11
21 17174972-TableS1 Human Zola07 426genes CellDifferentiationMarkers GeneSigDB 3.196E-3 4.882E-2
3.140E-1
1.000E0
 2 345
22 19112599-Table2b Human Breast Ellsworth09 13genes GeneSigDB 3.367E-3 4.882E-2
3.140E-1
1.000E0
 1 13
23 18849563-Table5 Human Lung not cancer Bhattacharya09 16genes GeneSigDB 3.367E-3 4.882E-2
3.140E-1
1.000E0
 1 13
24 M9811 Genes up-regulated in 293 cells (embryonic kidney) expressing polymorphic variants S427G (SNP ID=rs2070235) or I624M (SNP ID=rs11556379) of BMYB [GeneID=4605]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.367E-3 4.882E-2
3.140E-1
1.000E0
 1 13
Show 19 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 163 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 6 input genes in category / 35 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 150 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3195:mirSVR lowEffct hsa-miR-3195:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.022E-5 7.533E-3 4.212E-2 7.533E-3 2 133
2 hsa-miR-886-5p:mirSVR lowEffct hsa-miR-886-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.686E-4 2.765E-2
1.546E-1
5.529E-2
 2 361
3 hsa-miR-3199:mirSVR highEffct hsa-miR-3199:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.682E-4 3.341E-2
1.868E-1
1.002E-1
 2 487
4 hsa-miR-887-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.411E-3 3.475E-2
1.943E-1
2.117E-1
 1 17
5 hsa-miR-8056:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 3.475E-2
1.943E-1
3.858E-1
 1 31
6 hsa-miR-210-3p:TargetScan hsa-miR-210-3p TargetScan 2.655E-3 3.475E-2
1.943E-1
3.982E-1
 1 32
7 hsa-miR-643:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.401E-3 3.475E-2
1.943E-1
5.101E-1
 1 41
8 hsa-miR-3670:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 3.475E-2
1.943E-1
5.970E-1
 1 48
9 hsa-miR-1284:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.475E-2
1.943E-1
6.094E-1
 1 49
10 hsa-miR-4320:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.475E-2
1.943E-1
6.094E-1
 1 49
11 hsa-miR-3162-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 3.475E-2
1.943E-1
6.467E-1
 1 52
12 hsa-miR-1910-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.890E-3 3.475E-2
1.943E-1
7.336E-1
 1 59
13 hsa-miR-488-5p:Functional MTI Functional MTI miRTarbase 4.890E-3 3.475E-2
1.943E-1
7.336E-1
 1 59
14 hsa-miR-4758-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.475E-2
1.943E-1
7.956E-1
 1 64
15 hsa-miR-1238-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 3.475E-2
1.943E-1
8.328E-1
 1 67
16 hsa-miR-2054:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.475E-2
1.943E-1
9.320E-1
 1 75
17 hsa-miR-6505-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.461E-3 3.475E-2
1.943E-1
9.692E-1
 1 78
18 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 3.475E-2
1.943E-1
1.000E0
 1 83
19 hsa-miR-1234:mirSVR highEffct hsa-miR-1234:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.287E-3 3.475E-2
1.943E-1
1.000E0
 1 88
20 hsa-miR-8087:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 3.475E-2
1.943E-1
1.000E0
 1 94
21 hsa-miR-4264:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.475E-2
1.943E-1
1.000E0
 1 98
22 hsa-miR-4801:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.475E-2
1.943E-1
1.000E0
 1 98
23 hsa-miR-4731-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.195E-3 3.475E-2
1.943E-1
1.000E0
 1 99
24 hsa-miR-4303:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.277E-3 3.475E-2
1.943E-1
1.000E0
 1 100
25 hsa-miR-3616-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.442E-3 3.475E-2
1.943E-1
1.000E0
 1 102
26 hsa-miR-708-5p:Functional MTI Functional MTI miRTarbase 8.607E-3 3.475E-2
1.943E-1
1.000E0
 1 104
27 hsa-miR-890:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 3.475E-2
1.943E-1
1.000E0
 1 105
28 hsa-miR-338-5p:Non-Functional MTI Non-Functional MTI miRTarbase 8.689E-3 3.475E-2
1.943E-1
1.000E0
 1 105
29 hsa-miR-6761-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.937E-3 3.475E-2
1.943E-1
1.000E0
 1 108
30 hsa-miR-4329:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.267E-3 3.475E-2
1.943E-1
1.000E0
 1 112
31 hsa-miR-3978:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.596E-3 3.475E-2
1.943E-1
1.000E0
 1 116
32 hsa-miR-4251:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.001E-2 3.475E-2
1.943E-1
1.000E0
 1 121
33 hsa-miR-6081:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.009E-2 3.475E-2
1.943E-1
1.000E0
 1 122
34 hsa-miR-210-3p:Functional MTI Functional MTI miRTarbase 1.017E-2 3.475E-2
1.943E-1
1.000E0
 1 123
35 hsa-miR-4481:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.050E-2 3.475E-2
1.943E-1
1.000E0
 1 127
36 hsa-miR-4745-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.058E-2 3.475E-2
1.943E-1
1.000E0
 1 128
37 hsa-miR-4646-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.100E-2 3.475E-2
1.943E-1
1.000E0
 1 133
38 hsa-miR-4632-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.100E-2 3.475E-2
1.943E-1
1.000E0
 1 133
39 hsa-miR-7843-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.100E-2 3.475E-2
1.943E-1
1.000E0
 1 133
40 hsa-miR-6735-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 3.475E-2
1.943E-1
1.000E0
 1 135
41 hsa-miR-6165:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.133E-2 3.475E-2
1.943E-1
1.000E0
 1 137
42 hsa-miR-4436b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.133E-2 3.475E-2
1.943E-1
1.000E0
 1 137
43 hsa-miR-6835-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.141E-2 3.475E-2
1.943E-1
1.000E0
 1 138
44 hsa-miR-6879-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.141E-2 3.475E-2
1.943E-1
1.000E0
 1 138
45 hsa-miR-513b-5p:Functional MTI Functional MTI miRTarbase 1.190E-2 3.475E-2
1.943E-1
1.000E0
 1 144
46 hsa-miR-3197:mirSVR highEffct hsa-miR-3197:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.223E-2 3.475E-2
1.943E-1
1.000E0
 1 148
47 hsa-miR-147a:Functional MTI Functional MTI miRTarbase 1.231E-2 3.475E-2
1.943E-1
1.000E0
 1 149
48 hsa-miR-1282:mirSVR highEffct hsa-miR-1282:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.297E-2 3.475E-2
1.943E-1
1.000E0
 1 157
49 hsa-miR-1276:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.322E-2 3.475E-2
1.943E-1
1.000E0
 1 160
50 hsa-miR-5582-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.338E-2 3.475E-2
1.943E-1
1.000E0
 1 162
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1025 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3614 UP Graveoline [485-61-0]; Up 200; 14.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.278E-5 7.335E-3
5.509E-2
 1.310E-2 3 199
2 CID000001495 AC1N4DEC Stitch 7.005E-5 7.335E-3
5.509E-2
7.180E-2
 2 50
3 CID011979316 vasopressin Stitch 9.365E-5 7.335E-3
5.509E-2
9.599E-2
 3 388
4 CID006328166 AC1O3H1D Stitch 1.262E-4 7.335E-3
5.509E-2
1.293E-1
 2 67
5 CID000002259 aurintricarboxylic acid Stitch 2.330E-4 7.335E-3
5.509E-2
2.389E-1
 2 91
6 CID006857691 AC1OAH2D Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
7 DB07212 N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
8 DB07071 (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
9 CID006857705 AC1OAH3J Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
10 CID003366356 AC1MOB6C Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
11 CID000043345 P 1075 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
12 ctd:C040190 S 2366 CTD 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
13 CID006328152 bismuth oxychloride Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
14 DB07077 (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
15 ctd:D003040 Cobra Venoms CTD 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
16 DB07074 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
17 CID000129312 NA 0345 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
18 CID000159960 Campel Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
19 CID006857702 AC1OAH3A Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
20 CID006857688 DB07023 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
21 CID006857700 AC1OAH34 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
22 CID011304895 DB07022 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
23 CID009953722 BIBM1015 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
24 CID006857697 AC1OAH2V Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
25 CID006857687 AC1OAH21 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
26 CID005282453 polyquaternium-1 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
27 CID000594044 A26-61 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
28 CID006852141 DB07074 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
29 DB07887 (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
30 DB07299 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
31 CID006857698 2fda Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
32 CID006857692 AC1OAH2G Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
33 DB07023 (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
34 CID006852140 DB07212 Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
35 DB07022 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE Drug Bank 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
36 CID006857695 AC1OAH2P Stitch 2.627E-4 7.335E-3
5.509E-2
2.693E-1
 1 1
37 CID000024380 FeCl3 Stitch 2.648E-4 7.335E-3
5.509E-2
2.714E-1
 2 97
38 CID003036757 PPACK Stitch 3.592E-4 9.689E-3
7.277E-2
3.682E-1
 2 113
39 CID000027991 DDAVP Stitch 4.254E-4 1.118E-2
8.397E-2
4.360E-1
 2 123
40 CID003080721 TUDP Stitch 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
41 CID000448593 2srt Stitch 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
42 ctd:D007616 Kaolin CTD 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
43 CID000127283 Ppmc Stitch 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
44 CID000076047 bromophenol red Stitch 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
45 CID000204937 Pb 30 Stitch 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
46 CID000203734 B328 Stitch 5.253E-4 1.171E-2
8.791E-2
5.384E-1
 1 2
47 CID000000564 EACA Stitch 6.400E-4 1.396E-2
1.048E-1
6.560E-1
 2 151
48 CID002771670 imidazo[1,2-a]pyrazine Stitch 7.879E-4 1.553E-2
1.166E-1
8.076E-1
 1 3
49 CID006540266 2bq6 Stitch 7.879E-4 1.553E-2
1.166E-1
8.076E-1
 1 3
50 CID005289220 DB08434 Stitch 7.879E-4 1.553E-2
1.166E-1
8.076E-1
 1 3
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 309 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0005129 Bernard-Soulier Syndrome DisGeNET Curated 6.467E-8 1.998E-5 1.261E-4 1.998E-5 3 25
2 C1458140 Bleeding tendency DisGeNET Curated 2.181E-7 2.647E-5 1.671E-4 6.740E-5 3 37
3 cv:C0005129 Bernard Soulier syndrome Clinical Variations 3.427E-7 2.647E-5 1.671E-4 1.059E-4 2 3
4 OMIN:231200 BERNARD-SOULIER SYNDROME; BSS OMIM 3.427E-7 2.647E-5 1.671E-4 1.059E-4 2 3
5 C3854603 FNAITP DisGeNET Curated 1.713E-6 8.820E-5 5.567E-4 5.292E-4 2 6
6 C1096367 Increased mean platelet volume DisGeNET Curated 1.713E-6 8.820E-5 5.567E-4 5.292E-4 2 6
7 C4020869 Abnormality of the abdomen DisGeNET Curated 1.038E-5 4.580E-4 2.891E-3 3.206E-3 2 14
8 C0025323 Menorrhagia DisGeNET Curated 1.550E-5 5.321E-4 3.359E-3 4.789E-3 2 17
9 C0031256 Petechiae DisGeNET Curated 1.550E-5 5.321E-4 3.359E-3 4.789E-3 2 17
10 C0034150 Purpura DisGeNET Curated 4.618E-5 1.427E-3 9.007E-3 1.427E-2 2 29
11 C0151529 Bleeding time prolonged DisGeNET Curated 5.287E-5 1.485E-3 9.375E-3 1.634E-2 2 31
12 C0042974 von Willebrand Disease DisGeNET BeFree 6.761E-5 1.741E-3 1.099E-2 2.089E-2 2 35
13 C0014591 Epistaxis DisGeNET Curated 1.025E-4 2.436E-3 1.537E-2 3.166E-2 2 43
14 OMIN:300584 IMMUNODEFICIENCY WITHOUT ANHIDROTIC ECTODERMAL DYSPLASIA OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
15 C1845919 Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
16 C0266009 Congenital absence of breast DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
17 C4225596 INCONTINENTIA PIGMENTI, ATYPICAL DisGeNET BeFree 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
18 cv:C1845919 Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
19 C4025314 Atrophic, patchy alopecia DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
20 cv:C2750610 Bernard-Soulier syndrome, type A2, autosomal dominant Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
21 OMIN:300640 INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2; IPD2 OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
22 cv:C1280798 Pseudo von Willebrand disease Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
23 OMIN:308300 INCONTINENTIA PIGMENTI; IP OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
24 cv:C1845073 Invasive pneumococcal disease, recurrent isolated, 2 Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
25 C3277076 BERNARD-SOULIER SYNDROME, TYPE A2, AUTOSOMAL DOMINANT DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
26 OMIN:258660 NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY, SUSCEPTIBILITY TO OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
27 cv:C1847711 Nonarteritic anterior ischemic optic neuropathy, susceptibility to Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
28 OMIN:177820 PSEUDO-VON WILLEBRAND DISEASE OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
29 C1970879 ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
30 OMIN:612416 FACTOR XI DEFICIENCY OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
31 C1845117 Immunodeficiency without anhidrotic ectodermal dysplasia DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
32 cv:C0015523 Hereditary factor XI deficiency disease Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
33 cv:C1970879 X-linked familial atypical mycobacteriosis, type 1 Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
34 C1969572 Prolonged bleeding after dental extraction DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
35 cv:C1846006 Hypohidrotic ectodermal dysplasia with immune deficiency Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
36 C1845073 INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
37 cv:C1845117 Immunodeficiency without anhidrotic ectodermal dysplasia Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
38 OMIN:300636 ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1; AMCBX1 OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
39 C1847711 NONARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY, SUSCEPTIBILITY TO DisGeNET Curated 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
40 OMIN:153670 BERNARD-SOULIER SYNDROME, AUTOSOMAL DOMINANT OMIM 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
41 cv:C0021171 Incontinentia pigmenti syndrome Clinical Variations 3.703E-4 2.790E-3 1.761E-2
1.144E-1
 1 1
42 C0019069 Hemophilia A DisGeNET Curated 4.815E-4 3.542E-3 2.236E-2
1.488E-1
 2 93
43 C0392386 Decreased platelet count DisGeNET Curated 6.974E-4 4.669E-3 2.947E-2
2.155E-1
 2 112
44 C0220992 Histidinemia DisGeNET Curated 7.404E-4 4.669E-3 2.947E-2
2.288E-1
 1 2
45 C0343537 Specific viral infections DisGeNET BeFree 7.404E-4 4.669E-3 2.947E-2
2.288E-1
 1 2
46 C1839167 Intermittent thrombocytopenia DisGeNET Curated 7.404E-4 4.669E-3 2.947E-2
2.288E-1
 1 2
47 C1737260 Recurrent mycobacterium avium complex infections DisGeNET Curated 7.404E-4 4.669E-3 2.947E-2
2.288E-1
 1 2
48 C0272340 High molecular weight kininogen deficiency DisGeNET Curated 7.404E-4 4.669E-3 2.947E-2
2.288E-1
 1 2
49 C4025109 Abnormal hand morphology DisGeNET Curated 7.404E-4 4.669E-3 2.947E-2
2.288E-1
 1 2
50 C0008767 Cicatrization DisGeNET Curated 1.110E-3 6.239E-3 3.938E-2
3.431E-1
 1 3
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