Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc281_10, positive side

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1: GO: Molecular Function [Display Chart] 10 input genes in category / 53 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051721 protein phosphatase 2A binding 7.188E-7 3.810E-5 1.736E-4 3.810E-5 3 35
2 GO:0070016 armadillo repeat domain binding 2.010E-5 5.326E-4 2.427E-3 1.065E-3 2 13
3 GO:0019903 protein phosphatase binding 4.978E-5 8.795E-4 4.008E-3 2.638E-3 3 142
4 GO:0019902 phosphatase binding 1.128E-4 1.254E-3 5.713E-3 5.980E-3 3 187
5 GO:0005516 calmodulin binding 1.183E-4 1.254E-3 5.713E-3 6.269E-3 3 190
6 GO:0016005 phospholipase A2 activator activity 1.071E-3 9.465E-3 4.313E-2
5.679E-2
 1 2
7 GO:0061676 importin-alpha family protein binding 1.607E-3 1.065E-2 4.851E-2
8.516E-2
 1 3
8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis 1.607E-3 1.065E-2 4.851E-2
8.516E-2
 1 3
9 GO:0005519 cytoskeletal regulatory protein binding 2.142E-3 1.261E-2
5.748E-2
1.135E-1
 1 4
10 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 6.413E-3 3.090E-2
1.408E-1
3.399E-1
 1 12
11 GO:0016004 phospholipase activator activity 6.413E-3 3.090E-2
1.408E-1
3.399E-1
 1 12
12 GO:0060229 lipase activator activity 7.479E-3 3.266E-2
1.488E-1
3.964E-1
 1 14
13 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process 8.011E-3 3.266E-2
1.488E-1
4.246E-1
 1 15
14 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1.067E-2 3.957E-2
1.803E-1
5.654E-1
 1 20
15 GO:0005123 death receptor binding 1.120E-2 3.957E-2
1.803E-1
5.936E-1
 1 21
16 GO:0016505 peptidase activator activity involved in apoptotic process 1.226E-2 4.061E-2
1.851E-1
6.498E-1
 1 23
17 GO:0030291 protein serine/threonine kinase inhibitor activity 1.596E-2 4.961E-2
2.261E-1
8.461E-1
 1 30
18 GO:0001786 phosphatidylserine binding 1.755E-2 4.961E-2
2.261E-1
9.300E-1
 1 33
19 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1.913E-2 4.961E-2
2.261E-1
1.000E0
 1 36
20 GO:0004190 aspartic-type endopeptidase activity 1.913E-2 4.961E-2
2.261E-1
1.000E0
 1 36
21 GO:0070001 aspartic-type peptidase activity 1.966E-2 4.961E-2
2.261E-1
1.000E0
 1 37
Show 16 more annotations

2: GO: Biological Process [Display Chart] 10 input genes in category / 393 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0051645 Golgi localization 2.018E-5 3.556E-3 2.330E-2 7.930E-3 2 13
2 GO:0048313 Golgi inheritance 2.354E-5 3.556E-3 2.330E-2 9.249E-3 2 14
3 GO:0048308 organelle inheritance 2.715E-5 3.556E-3 2.330E-2 1.067E-2 2 15

3: GO: Cellular Component [Display Chart] 10 input genes in category / 62 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043197 dendritic spine 7.659E-7 2.503E-5 1.179E-4 4.749E-5 4 151
2 GO:0044309 neuron spine 8.073E-7 2.503E-5 1.179E-4 5.005E-5 4 153
3 GO:0000159 protein phosphatase type 2A complex 4.683E-5 8.835E-4 4.164E-3 2.904E-3 2 20
4 GO:0098794 postsynapse 5.700E-5 8.835E-4 4.164E-3 3.534E-3 4 449
5 GO:1903293 phosphatase complex 2.994E-4 3.094E-3 1.458E-2 1.856E-2 2 50
6 GO:0008287 protein serine/threonine phosphatase complex 2.994E-4 3.094E-3 1.458E-2 1.856E-2 2 50
7 GO:0032580 Golgi cisterna membrane 6.735E-4 5.966E-3 2.811E-2 4.176E-2 2 75
8 GO:0044307 dendritic branch 1.049E-3 8.130E-3 3.831E-2
6.504E-2
 1 2
9 GO:0031985 Golgi cisterna 1.193E-3 8.219E-3 3.873E-2
7.397E-2
 2 100
10 GO:0042585 germinal vesicle 1.573E-3 9.183E-3 4.327E-2
9.754E-2
 1 3
11 GO:0015629 actin cytoskeleton 1.629E-3 9.183E-3 4.327E-2
1.010E-1
 3 476
12 GO:0005795 Golgi stack 2.065E-3 1.067E-2
5.028E-2
1.280E-1
 2 132
13 GO:0001674 female germ cell nucleus 3.144E-3 1.499E-2
7.066E-2
1.949E-1
 1 6
14 GO:0000137 Golgi cis cisterna 4.190E-3 1.732E-2
8.161E-2
2.598E-1
 1 8
15 GO:0032059 bleb 4.190E-3 1.732E-2
8.161E-2
2.598E-1
 1 8
16 GO:0031264 death-inducing signaling complex 4.713E-3 1.826E-2
8.606E-2
2.922E-1
 1 9
17 GO:0001520 outer dense fiber 5.757E-3 2.100E-2
9.895E-2
3.570E-1
 1 11
18 GO:0033391 chromatoid body 7.322E-3 2.522E-2
1.189E-1
4.540E-1
 1 14
19 GO:0005938 cell cortex 8.109E-3 2.646E-2
1.247E-1
5.028E-1
 2 266
20 GO:0099568 cytoplasmic region 1.191E-2 3.538E-2
1.667E-1
7.387E-1
 2 325
21 GO:0098791 Golgi subcompartment 1.199E-2 3.538E-2
1.667E-1
7.431E-1
 2 326
22 GO:0031984 organelle subcompartment 1.306E-2 3.681E-2
1.734E-1
8.097E-1
 2 341
23 GO:0043073 germ cell nucleus 1.408E-2 3.795E-2
1.788E-1
8.729E-1
 1 27
24 GO:0030133 transport vesicle 1.557E-2 4.022E-2
1.895E-1
9.653E-1
 2 374
25 GO:0005874 microtubule 1.991E-2 4.836E-2
2.279E-1
1.000E0
 2 426
26 GO:0005801 cis-Golgi network 2.028E-2 4.836E-2
2.279E-1
1.000E0
 1 39
Show 21 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 41 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012749 Focal T2 hypointense brainstem lesion 1.274E-3 1.045E-2 4.497E-2
5.225E-2
 1 3
2 HP:0011513 Retinal cavernous angioma 1.274E-3 1.045E-2 4.497E-2
5.225E-2
 1 3
3 HP:0030430 Neuroma 1.274E-3 1.045E-2 4.497E-2
5.225E-2
 1 3
4 HP:0007797 Retinal vascular malformation 1.274E-3 1.045E-2 4.497E-2
5.225E-2
 1 3
5 HP:0012748 Focal T2 hyperintense brainstem lesion 1.274E-3 1.045E-2 4.497E-2
5.225E-2
 1 3
6 HP:0007872 Choroidal hemangioma 1.699E-3 1.161E-2 4.996E-2
6.966E-2
 1 4
7 HP:0012747 Abnormal brainstem MRI signal intensity 2.124E-3 1.244E-2
5.352E-2
8.707E-2
 1 5
8 HP:0006576 Hepatic vascular malformations 2.972E-3 1.354E-2
5.827E-2
1.219E-1
 1 7
9 HP:0012721 Venous malformation 2.972E-3 1.354E-2
5.827E-2
1.219E-1
 1 7
10 HP:0002572 Episodic vomiting 1.017E-2 4.171E-2
1.795E-1
4.171E-1
 1 24
Show 5 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 285 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 10 input genes in category / 53 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR013258 Striatin N InterPro 7.691E-7 2.037E-5 9.284E-5 4.076E-5 2 3
2 PF08232 Striatin Pfam 7.691E-7 2.037E-5 9.284E-5 4.076E-5 2 3
3 PF09727 CortBP2 Pfam 1.538E-6 2.037E-5 9.284E-5 8.150E-5 2 4
4 IPR019131 Cortactin-binding p2 N InterPro 1.538E-6 2.037E-5 9.284E-5 8.150E-5 2 4
5 IPR015470 Caspase 3 InterPro 5.338E-4 3.327E-3 1.516E-2 2.829E-2 1 1
6 IPR009652 PDCD10 InterPro 5.338E-4 3.327E-3 1.516E-2 2.829E-2 1 1
7 IPR020472 G-protein beta WD-40 rep InterPro 8.940E-4 3.327E-3 1.516E-2 4.738E-2 2 85
8 PF02063 MARCKS Pfam 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
9 SM01292 N1221 SMART 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
10 PS00826 MARCKS 1 PROSITE 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
11 PF07923 N1221 Pfam 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
12 IPR002101 MARCKS InterPro 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
13 PS00827 MARCKS 2 PROSITE 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
14 SM01293 DUF3402 SMART 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
15 IPR012486 N1221 InterPro 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
16 PF11882 DUF3402 Pfam 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
17 IPR021819 DUF3402 InterPro 1.067E-3 3.327E-3 1.516E-2
5.657E-2
 1 2
18 IPR019775 WD40 repeat CS InterPro 3.273E-3 8.988E-3 4.096E-2
1.735E-1
 2 164
19 PF03637 Mob1 phocein Pfam 3.731E-3 8.988E-3 4.096E-2
1.977E-1
 1 7
20 IPR005301 MOB kinase act fam InterPro 3.731E-3 8.988E-3 4.096E-2
1.977E-1
 1 7
21 1.20.140.30 - Gene3D 3.731E-3 8.988E-3 4.096E-2
1.977E-1
 1 7
22 SM01388 Mob1 phocein SMART 3.731E-3 8.988E-3 4.096E-2
1.977E-1
 1 7
23 PS01121 CASPASE HIS PROSITE 5.857E-3 1.161E-2
5.292E-2
3.104E-1
 1 11
24 PS01122 CASPASE CYS PROSITE 6.388E-3 1.161E-2
5.292E-2
3.386E-1
 1 12
25 IPR002138 Pept C14 p10 InterPro 6.388E-3 1.161E-2
5.292E-2
3.386E-1
 1 12
26 IPR016129 Caspase his AS InterPro 6.388E-3 1.161E-2
5.292E-2
3.386E-1
 1 12
27 IPR033139 Caspase cys AS InterPro 6.388E-3 1.161E-2
5.292E-2
3.386E-1
 1 12
28 PS50207 CASPASE P10 PROSITE 6.388E-3 1.161E-2
5.292E-2
3.386E-1
 1 12
29 IPR015917 Pept C14A InterPro 6.919E-3 1.161E-2
5.292E-2
3.667E-1
 1 13
30 SM00115 CASc SMART 6.919E-3 1.161E-2
5.292E-2
3.667E-1
 1 13
31 PS50208 CASPASE P20 PROSITE 7.449E-3 1.161E-2
5.292E-2
3.948E-1
 1 14
32 IPR029030 Caspase-like dom InterPro 7.449E-3 1.161E-2
5.292E-2
3.948E-1
 1 14
33 IPR001309 Pept C14 p20 InterPro 7.449E-3 1.161E-2
5.292E-2
3.948E-1
 1 14
34 3.40.50.1460 - Gene3D 7.449E-3 1.161E-2
5.292E-2
3.948E-1
 1 14
35 PF00400 WD40 Pfam 7.963E-3 1.206E-2
5.495E-2
4.220E-1
 2 259
36 SM00320 WD40 SMART 8.505E-3 1.207E-2
5.502E-2
4.508E-1
 2 268
37 IPR001680 WD40 repeat InterPro 8.751E-3 1.207E-2
5.502E-2
4.638E-1
 2 272
38 PS00678 WD REPEATS 1 PROSITE 9.126E-3 1.207E-2
5.502E-2
4.837E-1
 2 278
39 PS50082 WD REPEATS 2 PROSITE 9.190E-3 1.207E-2
5.502E-2
4.871E-1
 2 279
40 PS50294 WD REPEATS REGION PROSITE 9.190E-3 1.207E-2
5.502E-2
4.871E-1
 2 279
41 IPR024858 Golgin A InterPro 9.569E-3 1.207E-2
5.502E-2
5.071E-1
 1 18
42 PF15070 GOLGA2L5 Pfam 9.569E-3 1.207E-2
5.502E-2
5.071E-1
 1 18
43 IPR017986 WD40 repeat dom InterPro 1.036E-2 1.277E-2
5.820E-2
5.492E-1
 2 297
44 2.130.10.10 - Gene3D 1.290E-2 1.537E-2
7.002E-2
6.836E-1
 2 333
45 IPR015943 WD40/YVTN repeat-like dom InterPro 1.305E-2 1.537E-2
7.002E-2
6.915E-1
 2 335
Show 40 more annotations

7: Pathway [Display Chart] 5 input genes in category / 106 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270294 Stimulation of the cell death response by PAK-2p34 BioSystems: REACTOME 8.031E-4 2.831E-2
1.485E-1
8.513E-2
 1 2
2 1270286 SMAC-mediated dissociation of IAP:caspase complexes BioSystems: REACTOME 2.007E-3 2.831E-2
1.485E-1
2.127E-1
 1 5
3 1270284 SMAC-mediated apoptotic response BioSystems: REACTOME 2.007E-3 2.831E-2
1.485E-1
2.127E-1
 1 5
4 1270281 Cytochrome c-mediated apoptotic response BioSystems: REACTOME 2.007E-3 2.831E-2
1.485E-1
2.127E-1
 1 5
5 1270283 Activation of caspases through apoptosome-mediated cleavage BioSystems: REACTOME 2.007E-3 2.831E-2
1.485E-1
2.127E-1
 1 5
6 1270285 SMAC binds to IAPs BioSystems: REACTOME 2.007E-3 2.831E-2
1.485E-1
2.127E-1
 1 5
7 PW:0000106 extrinsic apoptotic Pathway Ontology 2.408E-3 2.831E-2
1.485E-1
2.552E-1
 1 6
8 1269450 NADE modulates death signalling BioSystems: REACTOME 2.408E-3 2.831E-2
1.485E-1
2.552E-1
 1 6
9 1270280 Apoptotic factor-mediated response BioSystems: REACTOME 2.809E-3 2.831E-2
1.485E-1
2.977E-1
 1 7
10 M5060 The TNF-type receptor Fas induces apoptosis on ligand binding. MSigDB C2 BIOCARTA (v6.0) 3.610E-3 2.831E-2
1.485E-1
3.826E-1
 1 9
11 M7239 Apoptotic DNA fragmentation and tissue homeostasis MSigDB C2 BIOCARTA (v6.0) 4.010E-3 2.831E-2
1.485E-1
4.251E-1
 1 10
12 1270104 Acetylcholine regulates insulin secretion BioSystems: REACTOME 4.010E-3 2.831E-2
1.485E-1
4.251E-1
 1 10
13 1270267 Ligand-independent caspase activation via DCC BioSystems: REACTOME 4.411E-3 2.831E-2
1.485E-1
4.675E-1
 1 11
14 1270290 Apoptotic cleavage of cell adhesion proteins BioSystems: REACTOME 4.411E-3 2.831E-2
1.485E-1
4.675E-1
 1 11
15 M15513 D4-GDI Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 5.211E-3 2.831E-2
1.485E-1
5.523E-1
 1 13
16 1270293 Activation of DNA fragmentation factor BioSystems: REACTOME 5.211E-3 2.831E-2
1.485E-1
5.523E-1
 1 13
17 1270289 Caspase-mediated cleavage of cytoskeletal proteins BioSystems: REACTOME 5.211E-3 2.831E-2
1.485E-1
5.523E-1
 1 13
18 1270292 Apoptosis induced DNA fragmentation BioSystems: REACTOME 5.211E-3 2.831E-2
1.485E-1
5.523E-1
 1 13
19 852705 MicroRNAs in cancer BioSystems: KEGG 5.479E-3 2.831E-2
1.485E-1
5.808E-1
 2 299
20 1269812 Golgi Cisternae Pericentriolar Stack Reorganization BioSystems: REACTOME 5.611E-3 2.831E-2
1.485E-1
5.947E-1
 1 14
21 PW:0000009 programmed cell death Pathway Ontology 6.011E-3 2.831E-2
1.485E-1
6.371E-1
 1 15
22 M2587 Stress Induction of HSP Regulation MSigDB C2 BIOCARTA (v6.0) 6.011E-3 2.831E-2
1.485E-1
6.371E-1
 1 15
23 PW:0000018 Parkinson disease Pathway Ontology 6.410E-3 2.831E-2
1.485E-1
6.795E-1
 1 16
24 M4835 B Cell Survival Pathway MSigDB C2 BIOCARTA (v6.0) 6.410E-3 2.831E-2
1.485E-1
6.795E-1
 1 16
25 M3430 Effects of calcineurin in Keratinocyte Differentiation MSigDB C2 BIOCARTA (v6.0) 7.608E-3 2.908E-2
1.526E-1
8.065E-1
 1 19
26 M7997 Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. MSigDB C2 BIOCARTA (v6.0) 7.608E-3 2.908E-2
1.526E-1
8.065E-1
 1 19
27 PW:0000017 Huntington disease Pathway Ontology 8.008E-3 2.908E-2
1.526E-1
8.488E-1
 1 20
28 M16257 Role of Mitochondria in Apoptotic Signaling MSigDB C2 BIOCARTA (v6.0) 8.407E-3 2.908E-2
1.526E-1
8.911E-1
 1 21
29 1269616 Signaling by Hippo BioSystems: REACTOME 8.407E-3 2.908E-2
1.526E-1
8.911E-1
 1 21
30 M3873 Apoptotic Signaling in Response to DNA Damage MSigDB C2 BIOCARTA (v6.0) 8.806E-3 2.908E-2
1.526E-1
9.334E-1
 1 22
31 M17902 Caspase Cascade in Apoptosis MSigDB C2 BIOCARTA (v6.0) 9.204E-3 2.908E-2
1.526E-1
9.757E-1
 1 23
32 1457788 Neurodegenerative Diseases BioSystems: REACTOME 9.204E-3 2.908E-2
1.526E-1
9.757E-1
 1 23
33 1457789 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models BioSystems: REACTOME 9.204E-3 2.908E-2
1.526E-1
9.757E-1
 1 23
34 PW:0000015 Alzheimer disease Pathway Ontology 9.603E-3 2.908E-2
1.526E-1
1.000E0
 1 24
35 PW:0000007 mitogen activated protein kinase signaling Pathway Ontology 9.603E-3 2.908E-2
1.526E-1
1.000E0
 1 24
36 138009 Plasma membrane estrogen receptor signaling BioSystems: Pathway Interaction Database 1.040E-2 2.998E-2
1.572E-1
1.000E0
 1 26
37 M7871 Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v6.0) 1.080E-2 2.998E-2
1.572E-1
1.000E0
 1 27
38 1270263 Caspase activation via extrinsic apoptotic signalling pathway BioSystems: REACTOME 1.120E-2 2.998E-2
1.572E-1
1.000E0
 1 28
39 M3618 TNFR1 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.159E-2 2.998E-2
1.572E-1
1.000E0
 1 29
40 PW:0000104 intrinsic apoptotic Pathway Ontology 1.159E-2 2.998E-2
1.572E-1
1.000E0
 1 29
41 M18030 Tumor Necrosis Factor Pathway. MSigDB C2 BIOCARTA (v6.0) 1.159E-2 2.998E-2
1.572E-1
1.000E0
 1 29
42 M9503 FAS signaling pathway ( CD95 ) MSigDB C2 BIOCARTA (v6.0) 1.199E-2 3.027E-2
1.588E-1
1.000E0
 1 30
43 P00020 FAS signaling pathway PantherDB 1.239E-2 3.038E-2
1.594E-1
1.000E0
 1 31
44 1384747 Apoptosis - multiple species BioSystems: KEGG 1.319E-2 3.038E-2
1.594E-1
1.000E0
 1 33
45 138031 Syndecan-2-mediated signaling events BioSystems: Pathway Interaction Database 1.319E-2 3.038E-2
1.594E-1
1.000E0
 1 33
46 M14971 Induction of apoptosis through DR3 and DR4/5 Death Receptors MSigDB C2 BIOCARTA (v6.0) 1.319E-2 3.038E-2
1.594E-1
1.000E0
 1 33
47 138081 FAS (CD95) signaling pathway BioSystems: Pathway Interaction Database 1.398E-2 3.087E-2
1.619E-1
1.000E0
 1 35
48 137995 HIV-1 Nef: Negative effector of Fas and TNF-alpha BioSystems: Pathway Interaction Database 1.398E-2 3.087E-2
1.619E-1
1.000E0
 1 35
49 1270288 Apoptotic cleavage of cellular proteins BioSystems: REACTOME 1.557E-2 3.368E-2
1.766E-1
1.000E0
 1 39
50 138007 PLK1 signaling events BioSystems: Pathway Interaction Database 1.755E-2 3.647E-2
1.913E-1
1.000E0
 1 44
Show 45 more annotations

8: Pubmed [Display Chart] 10 input genes in category / 3492 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18782753 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Pubmed 2.725E-19 9.515E-16 8.312E-15 9.515E-16 7 46
2 23277359 HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. Pubmed 4.786E-16 8.356E-13 7.300E-12 1.671E-12 5 13
3 19156129 An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Pubmed 8.728E-14 8.398E-11 7.336E-10 3.048E-10 6 107
4 24366813 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Pubmed 9.619E-14 8.398E-11 7.336E-10 3.359E-10 7 270
5 23455922 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Pubmed 3.290E-12 2.298E-9 2.007E-8 1.149E-8 7 446
6 24255178 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Pubmed 4.950E-10 2.881E-7 2.517E-6 1.728E-6 6 446
7 18571342 WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties. Pubmed 6.170E-8 2.693E-5 2.353E-4 2.155E-4 2 2
8 11251078 Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines. Pubmed 6.170E-8 2.693E-5 2.353E-4 2.155E-4 2 2
9 11319234 A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. Pubmed 1.851E-7 7.181E-5 6.273E-4 6.463E-4 2 3
10 15345747 Phosphoproteomic analysis of the developing mouse brain. Pubmed 2.899E-7 1.012E-4 8.843E-4 1.012E-3 4 236
11 10748158 Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. Pubmed 3.701E-7 1.175E-4 1.026E-3 1.292E-3 2 4
12 25743393 CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Pubmed 6.167E-7 1.657E-4 1.447E-3 2.154E-3 2 5
13 18502210 The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Pubmed 6.167E-7 1.657E-4 1.447E-3 2.154E-3 2 5
14 10681496 WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. Pubmed 9.250E-7 2.153E-4 1.881E-3 3.230E-3 2 6
15 25531779 STRIPAK components determine mode of cancer cell migration and metastasis. Pubmed 9.250E-7 2.153E-4 1.881E-3 3.230E-3 2 6
16 20332113 CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. Pubmed 1.295E-6 2.826E-4 2.469E-3 4.521E-3 2 7
17 29587143 A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Pubmed 2.773E-6 5.697E-4 4.977E-3 9.685E-3 2 10
18 29467281 The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics. Pubmed 4.038E-6 6.762E-4 5.907E-3 1.410E-2 3 125
19 24384391 Dual function of Yap in the regulation of lens progenitor cells and cellular polarity. Pubmed 4.067E-6 6.762E-4 5.907E-3 1.420E-2 2 12
20 20223754 The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Pubmed 4.067E-6 6.762E-4 5.907E-3 1.420E-2 2 12
21 27471260 Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis. Pubmed 4.067E-6 6.762E-4 5.907E-3 1.420E-2 2 12
22 27436040 Gestational stress induces the unfolded protein response, resulting in heart defects. Pubmed 4.805E-6 7.627E-4 6.663E-3 1.678E-2 2 13
23 21880782 Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Pubmed 5.605E-6 8.510E-4 7.434E-3 1.957E-2 2 14
24 30228103 Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics. Pubmed 7.390E-6 1.075E-3 9.392E-3 2.580E-2 2 16
25 16512683 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Pubmed 8.006E-6 1.118E-3 9.769E-3 2.796E-2 3 157
26 23533177 Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Pubmed 1.421E-5 1.808E-3 1.580E-2 4.963E-2 2 22
27 26383973 Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Pubmed 1.698E-5 1.808E-3 1.580E-2
5.928E-2
 2 24
28 24210661 Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Pubmed 2.158E-5 1.808E-3 1.580E-2
7.536E-2
 2 27
29 26685160 The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand. Pubmed 2.496E-5 1.808E-3 1.580E-2
8.715E-2
 2 29
30 30022023 The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Pubmed 2.496E-5 1.808E-3 1.580E-2
8.715E-2
 2 29
31 29180572 The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Pubmed 2.673E-5 1.808E-3 1.580E-2
9.336E-2
 2 30
32 17540176 The tumor suppressor PP2A Abeta regulates the RalA GTPase. Pubmed 3.048E-5 1.808E-3 1.580E-2
1.064E-1
 2 32
33 27802273 Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
34 9512515 Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
35 12169388 Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
36 21151119 Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
37 15033815 Glycoxidation of low-density lipoprotein increases TUNEL positivity and CPP32 activation in human coronary cells. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
38 23376641 Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
39 15803189 Absence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcome. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
40 21038681 [Effect of cisplatin on apoptosis of spiral ganglion cell and expression of caspase-3 in mouse cochlea]. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
41 16380626 CCM3 mutations are uncommon in cerebral cavernous malformations. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
42 25451273 Surveying genetic variants and molecular phylogeny of cerebral cavernous malformation gene, CCM3/PDCD10. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
43 12960074 Gene expression analysis of prostate hyperplasia in mice overexpressing the prolactin gene specifically in the prostate. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
44 19013511 KIOM-79 prevents apoptotic cell death and AGEs accumulation in retinas of diabetic db/db mice. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
45 12581734 Staurosporine-induced death of MCF-7 human breast cancer cells: a distinction between caspase-3-dependent steps of apoptosis and the critical lethal lesions. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
46 25909216 Deficiency of caspase 3 in tumor xenograft impairs therapeutic effect of measles virus Edmoston strain. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
47 23531848 Overexpression of survivin and caspase 3 in oral carcinogenesis. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
48 20862502 Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
49 28585712 A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
50 19056468 Excitatory tonus is required for the survival of granule cell precursors during postnatal development within the cerebellum. Pubmed 2.618E-4 1.808E-3 1.580E-2
9.143E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 10 input genes in category / 783 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:STK25 STK25 interactions 2.283E-19 1.788E-16 1.294E-15 1.788E-16 8 55
2 int:CTTNBP2 CTTNBP2 interactions 4.729E-18 1.415E-15 1.025E-14 3.703E-15 7 33
3 int:STK26 STK26 interactions 5.421E-18 1.415E-15 1.025E-14 4.245E-15 8 80
4 int:STK24 STK24 interactions 7.375E-18 1.444E-15 1.045E-14 5.774E-15 8 83
5 int:CTTNBP2NL CTTNBP2NL interactions 2.486E-17 3.893E-15 2.819E-14 1.946E-14 7 41
6 int:STRIP2 STRIP2 interactions 1.900E-16 2.480E-14 1.796E-13 1.488E-13 6 20
7 int:STRIP1 STRIP1 interactions 3.316E-16 3.245E-14 2.350E-13 2.596E-13 7 58
8 int:PDCD10 PDCD10 interactions 3.316E-16 3.245E-14 2.350E-13 2.596E-13 7 58
9 int:STRN3 STRN3 interactions 7.564E-15 6.581E-13 4.765E-12 5.922E-12 7 89
10 int:ZRANB1 ZRANB1 interactions 9.520E-15 7.454E-13 5.398E-12 7.454E-12 6 36
11 int:STRN STRN interactions 1.212E-14 7.873E-13 5.701E-12 9.490E-12 7 95
12 int:STRN4 STRN4 interactions 1.212E-14 7.873E-13 5.701E-12 9.490E-12 7 95
13 int:MOB4 MOB4 interactions 1.307E-14 7.873E-13 5.701E-12 1.023E-11 7 96
14 int:PRDM14 PRDM14 interactions 5.237E-14 2.929E-12 2.121E-11 4.101E-11 6 47
15 int:PPP2CA PPP2CA interactions 3.813E-13 1.991E-11 1.441E-10 2.986E-10 8 313
16 int:PPP2CB PPP2CB interactions 7.472E-13 3.657E-11 2.648E-10 5.850E-10 7 169
17 int:STK4 STK4 interactions 1.245E-12 5.735E-11 4.153E-10 9.750E-10 6 78
18 int:SPINK2 SPINK2 interactions 1.398E-12 6.079E-11 4.402E-10 1.094E-9 5 27
19 int:STK3 STK3 interactions 3.935E-12 1.622E-10 1.174E-9 3.081E-9 6 94
20 int:TRAF3IP3 TRAF3IP3 interactions 8.667E-12 3.232E-10 2.340E-9 6.786E-9 5 38
21 int:SIKE1 SIKE1 interactions 8.667E-12 3.232E-10 2.340E-9 6.786E-9 5 38
22 int:FGFR1OP2 FGFR1OP2 interactions 4.473E-11 1.592E-9 1.153E-8 3.502E-8 5 52
23 int:SLMAP SLMAP interactions 1.533E-10 5.219E-9 3.779E-8 1.200E-7 5 66
24 int:PPP2R1A PPP2R1A interactions 2.658E-10 8.673E-9 6.280E-8 2.081E-7 7 389
25 int:RASSF3 RASSF3 interactions 4.522E-10 1.416E-8 1.026E-7 3.541E-7 4 23
26 int:ZNF550 ZNF550 interactions 2.084E-9 6.276E-8 4.545E-7 1.632E-6 4 33
27 int:PPP2R1B PPP2R1B interactions 2.276E-9 6.601E-8 4.780E-7 1.782E-6 5 112
28 int:YPEL1 YPEL1 interactions 7.258E-9 2.030E-7 1.470E-6 5.683E-6 3 8
29 int:MCC MCC interactions 1.602E-8 4.324E-7 3.131E-6 1.254E-5 4 54
30 int:ZNF331 ZNF331 interactions 2.465E-8 6.435E-7 4.659E-6 1.930E-5 4 60
31 int:NHSL2 NHSL2 interactions 1.252E-7 3.162E-6 2.289E-5 9.801E-5 3 19
32 int:TNIK TNIK interactions 2.337E-7 5.719E-6 4.141E-5 1.830E-4 5 282
33 int:TNFRSF1A TNFRSF1A interactions 1.892E-6 4.490E-5 3.251E-4 1.482E-3 4 176
34 int:CCT8 CCT8 interactions 3.894E-6 8.968E-5 6.494E-4 3.049E-3 4 211
35 int:CCT5 CCT5 interactions 4.274E-6 9.358E-5 6.776E-4 3.346E-3 4 216
36 int:SNAI3 SNAI3 interactions 4.303E-6 9.358E-5 6.776E-4 3.369E-3 2 6
37 int:CCT6A CCT6A interactions 5.970E-6 1.263E-4 9.148E-4 4.675E-3 4 235
38 int:TCP1 TCP1 interactions 6.174E-6 1.272E-4 9.212E-4 4.834E-3 4 237
39 int:PKN1 PKN1 interactions 6.381E-6 1.281E-4 9.276E-4 4.996E-3 3 68
40 int:DYNLL1 DYNLL1 interactions 6.597E-6 1.291E-4 9.351E-4 5.165E-3 4 241
41 int:GIPC1 GIPC1 interactions 9.657E-6 1.844E-4 1.335E-3 7.561E-3 3 78
42 int:PKN3 PKN3 interactions 1.042E-5 1.943E-4 1.407E-3 8.161E-3 3 80
43 int:CCT2 CCT2 interactions 1.447E-5 2.634E-4 1.907E-3 1.133E-2 4 294
44 int:PCOLCE2 PCOLCE2 interactions 1.575E-5 2.798E-4 2.026E-3 1.233E-2 2 11
45 int:CCT3 CCT3 interactions 1.608E-5 2.798E-4 2.026E-3 1.259E-2 4 302
46 int:DFFB DFFB interactions 7.220E-5 1.203E-3 8.710E-3
5.653E-2
 2 23
47 int:LRRCC1 LRRCC1 interactions 7.220E-5 1.203E-3 8.710E-3
5.653E-2
 2 23
48 int:RAB29 RAB29 interactions 7.874E-5 1.284E-3 9.301E-3
6.165E-2
 2 24
49 int:ATP6V1C2 ATP6V1C2 interactions 8.556E-5 1.367E-3 9.900E-3
6.700E-2
 2 25
50 int:SNX24 SNX24 interactions 9.266E-5 1.451E-3 1.051E-2
7.256E-2
 2 26
Show 45 more annotations

10: Cytoband [Display Chart] 10 input genes in category / 10 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q22.2 6q22.2 5.769E-4 4.327E-3 1.267E-2 5.769E-3 1 2
2 14q13-q21 14q13-q21 8.653E-4 4.327E-3 1.267E-2 8.653E-3 1 3
3 4q34 4q34 1.442E-3 4.806E-3 1.408E-2 1.442E-2 1 5
4 2p22.2 2p22.2 4.607E-3 1.152E-2 3.374E-2 4.607E-2 1 16
5 7q31 7q31 7.763E-3 1.389E-2 4.070E-2
7.763E-2
 1 27
6 3q26.1 3q26.1 8.336E-3 1.389E-2 4.070E-2
8.336E-2
 1 29
7 1p13.2 1p13.2 1.348E-2 1.863E-2
5.456E-2
1.348E-1
 1 47
8 2q33.1 2q33.1 1.490E-2 1.863E-2
5.456E-2
1.490E-1
 1 52
9 9q34.11 9q34.11 1.689E-2 1.877E-2
5.498E-2
1.689E-1
 1 59
10 1p13.3 1p13.3 2.002E-2 2.002E-2
5.863E-2
2.002E-1
 1 70
Show 5 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 72 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1371 STRIPAK complex genenames.org 4.739E-21 2.843E-20 6.966E-20 2.843E-20 7 20
2 696 Protein phosphatase 2 regulatory subunits genenames.org 1.771E-5 5.314E-5 1.302E-4 1.063E-4 2 15
3 647 MOB kinase activators genenames.org 3.074E-3 6.149E-3 1.506E-2 1.845E-2 1 7
4 362 Ring finger proteins|WD repeat domain containing genenames.org 5.463E-3 6.844E-3 1.677E-2 3.278E-2 2 262
5 468 Caspases genenames.org 5.703E-3 6.844E-3 1.677E-2 3.422E-2 1 13

13: Coexpression [Display Chart] 10 input genes in category / 1021 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8250 Genes down-regulated in B lymphocytes: control versus stimulated by anti-IgM for 3h. MSigDB C7: Immunologic Signatures (v6.0) 3.552E-5 2.485E-2
1.865E-1
 3.627E-2 3 157
2 M4880 Genes up-regulated in comparison of neutrophils versus monocyte macrophages. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 2.485E-2
1.865E-1
7.455E-2
 3 200
3 M9625 Genes down-regulated in CD4 [GeneID=920] T helper cells Th0: control versus NaCl treatment. MSigDB C7: Immunologic Signatures (v6.0) 7.301E-5 2.485E-2
1.865E-1
7.455E-2
 3 200

14: Coexpression Atlas [Display Chart] 10 input genes in category / 566 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM854255 500 Myeloid Cells, DC.103-11b+.LuLN, MHCII+ CD11c+ CD8- CD11b+ CD103-, Lymph Node, avg-3 Immgen.org, GSE15907 5.140E-4 3.081E-2
2.131E-1
2.909E-1
 3 366
2 GSM854243 500 Myeloid Cells, DC.103+11b-.LuLN, MHCII+ CD11c+ CD8- CD11b- CD103+, Lymph Node, avg-3 Immgen.org, GSE15907 5.560E-4 3.081E-2
2.131E-1
3.147E-1
 3 376
3 GSM854290 500 Myeloid Cells, DC.8-4-11b-.SLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-1 Immgen.org, GSE15907 5.604E-4 3.081E-2
2.131E-1
3.172E-1
 3 377
4 GSM538277 500 Myeloid Cells, DC.IIhilang-103-11blo.SLN, MHCIIhi CD11c+ Langerin- CD103- CD11b-, Lymph Node, avg-3 Immgen.org, GSE15907 6.003E-4 3.081E-2
2.131E-1
3.398E-1
 3 386
5 GSM538268 500 Myeloid Cells, DC.IIhilang+103+11blo.SLN, MHCIIhi CD11c+ Langerin+ CD103+ CD11b-, Lymph Node, avg-3 Immgen.org, GSE15907 6.372E-4 3.081E-2
2.131E-1
3.607E-1
 3 394
6 GSM605834 500 Myeloid Cells, DC.8-4-11b-.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-2 Immgen.org, GSE15907 6.805E-4 3.081E-2
2.131E-1
3.852E-1
 3 403
7 GSM854287 500 Myeloid Cells, DC.8-4-11b+.SLN, CD11b-FITC CD4-PE CD11c-eFluor780 CD8a-eFluor450 C, Lymph Node, avg-1 Immgen.org, GSE15907 7.004E-4 3.081E-2
2.131E-1
3.964E-1
 3 407
8 GSM538274 500 Myeloid Cells, DC.IIhilang-103-11b+.SLN, MHCIIhi CD11c+ Langerin- CD103- CD11b+, Lymph Node, avg-3 Immgen.org, GSE15907 7.206E-4 3.081E-2
2.131E-1
4.079E-1
 3 411
9 GSM538271 500 Myeloid Cells, DC.IIhilang+103-11b+.SLN, MHCIIhi CD11c+ Langerin+ CD103- CD11b+, Lymph Node, avg-3 Immgen.org, GSE15907 7.257E-4 3.081E-2
2.131E-1
4.107E-1
 3 412
10 GSM538263 500 Myeloid Cells, DC.8-4-11b+.MLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-2 Immgen.org, GSE15907 7.308E-4 3.081E-2
2.131E-1
4.136E-1
 3 413
11 GSM538262 500 Myeloid Cells, DC.8-4-11b+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-1 Immgen.org, GSE15907 7.360E-4 3.081E-2
2.131E-1
4.166E-1
 3 414
12 GSM605836 500 Myeloid Cells, DC.8-4-11b-.MLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-3 Immgen.org, GSE15907 7.568E-4 3.081E-2
2.131E-1
4.284E-1
 3 418
13 GSM854291 500 Myeloid Cells, DC.8-4-11b-.SLN, CD11b-FITC CD4-PE CD11c-eFluor780 CD8a-eFluor450 C, Lymph Node, avg-3 Immgen.org, GSE15907 7.568E-4 3.081E-2
2.131E-1
4.284E-1
 3 418
14 GSM854285 500 Myeloid Cells, DC.8-4-11b+.SLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-2 Immgen.org, GSE15907 7.621E-4 3.081E-2
2.131E-1
4.314E-1
 3 419
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal fetal kidney Nephrogenesis/Kidney Normal fetal kidney F1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal fetal kidney Nephrogenesis/Kidney Normal fetal kidney F1 Adult, Development, and Cancer types 9.160E-4 3.456E-2
2.391E-1
5.185E-1
 1 2
16 gudmap dev gonad e13.5 M InterstitFLeydig MafB k2 1000 dev gonad e13.5 M InterstitFLeydig MafB k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.006E-3 3.558E-2
2.461E-1
5.692E-1
 2 105
Show 11 more annotations

15: Computational [Display Chart] 7 input genes in category / 33 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 10 input genes in category / 609 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 1.074E-7 4.135E-5 2.890E-4 6.540E-5 4 347
2 hsa-miR-30d-5p:Functional MTI Functional MTI miRTarbase 1.358E-7 4.135E-5 2.890E-4 8.270E-5 4 368
3 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 2.215E-7 4.496E-5 3.142E-4 1.349E-4 4 416
4 ACACTAC,MIR-142-3P:MSigDB ACACTAC,MIR-142-3P:MSigDB MSigDB 5.871E-7 8.939E-5 6.248E-4 3.575E-4 3 124
5 hsa-miR-142-3p:PITA hsa-miR-142-3p:PITA TOP PITA 2.436E-6 2.967E-4 2.074E-3 1.483E-3 3 199
6 GTTTGTT,MIR-495:MSigDB GTTTGTT,MIR-495:MSigDB MSigDB 4.061E-6 4.122E-4 2.881E-3 2.473E-3 3 236
7 hsa-miR-498:Functional MTI Functional MTI miRTarbase 1.010E-5 8.785E-4 6.140E-3 6.149E-3 3 320
8 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 2.808E-5 2.137E-3 1.494E-2 1.710E-2 3 451
9 hsa-miR-2053:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.283E-5 3.553E-3 2.483E-2 3.218E-2 2 79
10 hsa-miR-6889-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.834E-5 3.553E-3 2.483E-2 3.553E-2 2 83
11 hsa-miR-5585-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.710E-5 3.715E-3 2.597E-2 4.086E-2 2 89
12 hsa-miR-4715-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.082E-4 5.493E-3 3.840E-2
6.592E-2
 2 113
13 hsa-miR-525-3p:mirSVR highEffct hsa-miR-525-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.303E-4 5.947E-3 4.157E-2
7.937E-2
 2 124
14 hsa-miR-524-3p:mirSVR highEffct hsa-miR-524-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.367E-4 5.947E-3 4.157E-2
8.326E-2
 2 127
15 hsa-miR-770-5p:PITA hsa-miR-770-5p:PITA TOP PITA 1.568E-4 6.364E-3 4.449E-2
9.546E-2
 2 136
16 hsa-miR-33a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.806E-4 6.767E-3 4.730E-2
1.100E-1
 2 146
17 hsa-miR-581:PITA hsa-miR-581:PITA TOP PITA 1.906E-4 6.767E-3 4.730E-2
1.161E-1
 2 150
18 hsa-miR-758:PITA hsa-miR-758:PITA TOP PITA 2.035E-4 6.767E-3 4.730E-2
1.239E-1
 2 155
19 hsa-miR-432:PITA hsa-miR-432:PITA TOP PITA 2.168E-4 6.767E-3 4.730E-2
1.320E-1
 2 160
20 hsa-miR-885-5p:PITA hsa-miR-885-5p:PITA TOP PITA 2.305E-4 6.767E-3 4.730E-2
1.404E-1
 2 165
21 hsa-miR-567:PITA hsa-miR-567:PITA TOP PITA 2.333E-4 6.767E-3 4.730E-2
1.421E-1
 2 166
22 hsa-miR-3680-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.682E-4 7.423E-3
5.189E-2
1.633E-1
 2 178
23 hsa-miR-335:PITA hsa-miR-335:PITA TOP PITA 2.959E-4 7.834E-3
5.476E-2
1.802E-1
 2 187
24 hsa-miR-188-5p:PITA hsa-miR-188-5p:PITA TOP PITA 3.151E-4 7.834E-3
5.476E-2
1.919E-1
 2 193
25 hsa-miR-1305:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.216E-4 7.834E-3
5.476E-2
1.958E-1
 2 195
26 hsa-miR-425:PITA hsa-miR-425:PITA TOP PITA 3.382E-4 7.922E-3
5.537E-2
2.060E-1
 2 200
27 hsa-miR-297:PITA hsa-miR-297:PITA TOP PITA 4.621E-4 1.042E-2
7.286E-2
2.814E-1
 2 234
28 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 4.941E-4 1.075E-2
7.511E-2
3.009E-1
 2 242
29 hsa-miR-136:PITA hsa-miR-136:PITA TOP PITA 5.567E-4 1.107E-2
7.736E-2
3.390E-1
 2 257
30 hsa-miR-194:PITA hsa-miR-194:PITA TOP PITA 6.185E-4 1.107E-2
7.736E-2
3.767E-1
 2 271
31 hsa-miR-142-3p.1:TargetScan hsa-miR-142-3p.1 TargetScan 6.276E-4 1.107E-2
7.736E-2
3.822E-1
 2 273
32 ACATTCC,MIR-206:MSigDB ACATTCC,MIR-206:MSigDB MSigDB 6.740E-4 1.107E-2
7.736E-2
4.105E-1
 2 283
33 ACATTCC,MIR-1:MSigDB ACATTCC,MIR-1:MSigDB MSigDB 6.740E-4 1.107E-2
7.736E-2
4.105E-1
 2 283
34 hsa-miR-4789-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.221E-4 1.107E-2
7.736E-2
4.397E-1
 2 293
35 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 7.269E-4 1.107E-2
7.736E-2
4.427E-1
 2 294
36 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 7.269E-4 1.107E-2
7.736E-2
4.427E-1
 2 294
37 hsa-miR-449a:PITA hsa-miR-449a:PITA TOP PITA 7.319E-4 1.107E-2
7.736E-2
4.457E-1
 2 295
38 hsa-miR-34c-5p:PITA hsa-miR-34c-5p:PITA TOP PITA 7.319E-4 1.107E-2
7.736E-2
4.457E-1
 2 295
39 hsa-miR-34a:PITA hsa-miR-34a:PITA TOP PITA 7.319E-4 1.107E-2
7.736E-2
4.457E-1
 2 295
40 hsa-miR-449b:PITA hsa-miR-449b:PITA TOP PITA 7.319E-4 1.107E-2
7.736E-2
4.457E-1
 2 295
41 hsa-miR-606:PITA hsa-miR-606:PITA TOP PITA 7.616E-4 1.107E-2
7.736E-2
4.638E-1
 2 301
42 hsa-miR-342-3p:Functional MTI Functional MTI miRTarbase 7.768E-4 1.107E-2
7.736E-2
4.730E-1
 2 304
43 hsa-miR-335-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.818E-4 1.107E-2
7.736E-2
4.761E-1
 2 305
44 hsa-miR-512-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.023E-4 1.107E-2
7.736E-2
4.886E-1
 2 309
45 hsa-miR-1259:PITA hsa-miR-1259:PITA TOP PITA 8.178E-4 1.107E-2
7.736E-2
4.980E-1
 2 312
46 hsa-miR-4438:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.920E-4 1.181E-2
8.254E-2
5.432E-1
 2 326
47 hsa-miR-5589-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.358E-4 1.213E-2
8.476E-2
5.699E-1
 2 334
48 hsa-let-7g-5p:Functional MTI Functional MTI miRTarbase 9.750E-4 1.229E-2
8.589E-2
5.938E-1
 2 341
49 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 1.056E-3 1.229E-2
8.589E-2
6.430E-1
 2 355
50 hsa-miR-216a:PITA hsa-miR-216a:PITA TOP PITA 1.103E-3 1.229E-2
8.589E-2
6.719E-1
 2 363
Show 45 more annotations

17: Drug [Display Chart] 10 input genes in category / 5564 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C471674 10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone CTD 1.566E-5 1.668E-2
1.535E-1
8.710E-2
 2 14
2 CID000011496 AC1L1XHD Stitch 2.338E-5 1.668E-2
1.535E-1
1.301E-1
 2 17
3 ctd:D004040 Dietary Carbohydrates CTD 6.513E-5 1.668E-2
1.535E-1
3.624E-1
 3 190
4 1076 UP ICI 182,780; Up 200; 0.01uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 6.719E-5 1.668E-2
1.535E-1
3.738E-1
 3 192
5 7001 DN Rapamycin; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 6.929E-5 1.668E-2
1.535E-1
3.855E-1
 3 194
6 5489 DN Prenylamine lactate [69-43-2]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.143E-5 1.668E-2
1.535E-1
3.974E-1
 3 196
7 6372 DN 3-nitropropionic acid; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.252E-5 1.668E-2
1.535E-1
4.035E-1
 3 197
8 1693 UP Sulindac [38194-50-2]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.252E-5 1.668E-2
1.535E-1
4.035E-1
 3 197
9 2940 DN Methyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.473E-5 1.668E-2
1.535E-1
4.158E-1
 3 199
10 1542 DN Paclitaxel [33069-62-4]; Down 200; 4.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.473E-5 1.668E-2
1.535E-1
4.158E-1
 3 199
11 CID000164073 Pkcs Stitch 8.891E-5 1.668E-2
1.535E-1
4.947E-1
 3 211
12 CID000000684 deoxythymidine diphosphate-glucose Stitch 9.043E-5 1.668E-2
1.535E-1
5.032E-1
 2 33
13 CID000208907 ladostigil Stitch 2.007E-4 1.668E-2
1.535E-1
1.000E0
 2 49
14 ctd:C055494 caffeic acid phenethyl ester CTD 2.875E-4 1.668E-2
1.535E-1
1.000E0
 3 314
15 CID006914565 AC1OCA7P Stitch 3.536E-4 1.668E-2
1.535E-1
1.000E0
 2 65
16 CID000114736 PDMP Stitch 3.757E-4 1.668E-2
1.535E-1
1.000E0
 2 67
17 ctd:C018584 linalool CTD 4.338E-4 1.668E-2
1.535E-1
1.000E0
 2 72
18 ctd:C005998 dihydroxyfumarate CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
19 ctd:C507889 polylactide-polyethylene glycol-polylactide CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
20 CID000073677 stictic acid Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
21 ctd:C512706 4-(1-benzenesulfonyl-1H-indol-2-yl)-4-hydroxycyclohexa-2,5-dienone CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
22 ctd:C000977 dihydroouabain CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
23 CID005327325 Inhibitor 47a Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
24 CID005327344 Inhibitor 55 Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
25 ctd:C434652 tetrachloroguaiacol CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
26 ctd:C494582 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
27 CID000348462 methyl 3-oxo-3-phenylpropanoate Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
28 CID010255842 5-[[6-[[(2R)-1-carboxy-3-oxopropan-2-yl]amino]-6-oxo-5-thiophen-2-ylhexyl]sulfamoyl]-2-hydroxybenzoic acid Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
29 CID005321083 CID5321083 Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
30 ctd:C458523 BIBR 1532 CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
31 DB08497 (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate Drug Bank 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
32 ctd:C044556 2-iodomelatonin CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
33 DB03124 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Drug Bank 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
34 CID005327345 inhibitor 56 Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
35 CID000073726 diphenylpropane Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
36 CID005327330 Inhibitor 69a Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
37 DB08213 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE Drug Bank 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
38 CID011632008 Isoquinoline-1,3,4-trione 6k Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
39 CID005327316 Inhibitor 67a Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
40 DB08251 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID Drug Bank 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
41 ctd:C471867 4-(benzothiazol-2-yl)-4-hydroxy-2,5-cyclohexadien-1-one CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
42 ctd:C530601 arsenic triiodide CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
43 CID009870833 sulfonamide analog 9 Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
44 CID005327315 Inhibitor 65b Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
45 CID005476815 stannic;3-[(1Z,4Z,10Z,14Z)-18-(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinyl-porphine-21,22,23,24-tetraid-2-yl]propionic acid Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
46 CID010459952 sulfonamide analog 14 Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
47 ctd:C071861 inostamycin CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
48 ctd:C100269 ergocryptine CTD 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
49 CID005327339 inhibitor 50 Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
50 CID005327327 Inhibitor 67b Stitch 4.378E-4 1.668E-2
1.535E-1
1.000E0
 1 1
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 306 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1864040 Cerebral Cavernous Malformations 3 DisGeNET Curated 1.804E-5 5.522E-3 3.480E-2 5.522E-3 2 12
2 C2937358 Cerebral Hemorrhage DisGeNET Curated 2.115E-4 3.237E-2
2.040E-1
6.473E-2
 2 40
3 OMIN:603285 CEREBRAL CAVERNOUS MALFORMATIONS 3; CCM3 OMIM 5.554E-4 3.399E-2
2.142E-1
1.699E-1
 1 1
4 C0393971 Spinal cord stroke DisGeNET BeFree 5.554E-4 3.399E-2
2.142E-1
1.699E-1
 1 1
5 cv:C1864040 Cerebral cavernous malformations 3 Clinical Variations 5.554E-4 3.399E-2
2.142E-1
1.699E-1
 1 1