Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc29_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 42 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005212 structural constituent of eye lens 3.263E-8 1.370E-6 5.930E-6 1.370E-6 3 23
2 GO:0051082 unfolded protein binding 4.461E-4 6.613E-3 2.861E-2 1.874E-2 2 103
3 GO:0031072 heat shock protein binding 4.724E-4 6.613E-3 2.861E-2 1.984E-2 2 106
4 GO:0004517 nitric-oxide synthase activity 9.643E-4 1.013E-2 4.381E-2 4.050E-2 1 3
5 GO:0034617 tetrahydrobiopterin binding 1.286E-3 1.080E-2 4.672E-2
5.399E-2
 1 4
6 GO:0046870 cadmium ion binding 1.928E-3 1.157E-2
5.005E-2
8.097E-2
 1 6
7 GO:0055131 C3HC4-type RING finger domain binding 1.928E-3 1.157E-2
5.005E-2
8.097E-2
 1 6
8 GO:0034618 arginine binding 2.249E-3 1.181E-2
5.108E-2
9.445E-2
 1 7
9 GO:0044183 protein binding involved in protein folding 4.814E-3 2.022E-2
8.748E-2
2.022E-1
 1 15
10 GO:0010181 FMN binding 4.814E-3 2.022E-2
8.748E-2
2.022E-1
 1 15
11 GO:0050998 nitric-oxide synthase binding 7.054E-3 2.693E-2
1.165E-1
2.963E-1
 1 22
12 GO:0003785 actin monomer binding 8.332E-3 2.916E-2
1.262E-1
3.499E-1
 1 26
13 GO:0045296 cadherin binding 1.025E-2 3.226E-2
1.396E-1
4.303E-1
 1 32
14 GO:0051059 NF-kappaB binding 1.120E-2 3.226E-2
1.396E-1
4.705E-1
 1 35
15 GO:0051879 Hsp90 protein binding 1.152E-2 3.226E-2
1.396E-1
4.839E-1
 1 36
16 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1.343E-2 3.525E-2
1.525E-1
5.641E-1
 1 42
17 GO:0050661 NADP binding 1.534E-2 3.789E-2
1.639E-1
6.441E-1
 1 48
18 GO:0097110 scaffold protein binding 1.756E-2 4.097E-2
1.772E-1
7.374E-1
 1 55
19 GO:0003725 double-stranded RNA binding 2.167E-2 4.749E-2
2.055E-1
9.101E-1
 1 68
20 GO:0001618 virus receptor activity 2.262E-2 4.749E-2
2.055E-1
9.498E-1
 1 71
21 GO:0050660 flavin adenine dinucleotide binding 2.419E-2 4.838E-2
2.093E-1
1.000E0
 1 76
Show 16 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 366 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0009408 response to heat 1.015E-7 3.715E-5 2.407E-4 3.715E-5 4 171
2 GO:0009266 response to temperature stimulus 3.697E-7 6.766E-5 4.385E-4 1.353E-4 4 236
3 GO:0042026 protein refolding 2.182E-5 2.662E-3 1.725E-2 7.986E-3 2 23
4 GO:1900034 regulation of cellular response to heat 2.439E-4 1.685E-2
1.092E-1
8.928E-2
 2 76
5 GO:0006979 response to oxidative stress 2.468E-4 1.685E-2
1.092E-1
9.032E-2
 3 439
6 GO:0031439 positive regulation of mRNA cleavage 3.222E-4 1.685E-2
1.092E-1
1.179E-1
 1 1
7 GO:1902380 positive regulation of endoribonuclease activity 3.222E-4 1.685E-2
1.092E-1
1.179E-1
 1 1
8 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 5.388E-4 1.965E-2
1.274E-1
1.972E-1
 2 113
9 GO:0034605 cellular response to heat 5.388E-4 1.965E-2
1.274E-1
1.972E-1
 2 113
10 GO:0014806 smooth muscle hyperplasia 6.443E-4 1.965E-2
1.274E-1
2.358E-1
 1 2
11 GO:0031437 regulation of mRNA cleavage 6.443E-4 1.965E-2
1.274E-1
2.358E-1
 1 2
12 GO:0014740 negative regulation of muscle hyperplasia 6.443E-4 1.965E-2
1.274E-1
2.358E-1
 1 2
13 GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation 9.663E-4 2.050E-2
1.329E-1
3.537E-1
 1 3
14 GO:0014738 regulation of muscle hyperplasia 9.663E-4 2.050E-2
1.329E-1
3.537E-1
 1 3
15 GO:0060699 regulation of endoribonuclease activity 9.663E-4 2.050E-2
1.329E-1
3.537E-1
 1 3
16 GO:0032387 negative regulation of intracellular transport 1.089E-3 2.050E-2
1.329E-1
3.986E-1
 2 161
17 GO:2001236 regulation of extrinsic apoptotic signaling pathway 1.256E-3 2.050E-2
1.329E-1
4.596E-1
 2 173
18 GO:0006986 response to unfolded protein 1.270E-3 2.050E-2
1.329E-1
4.649E-1
 2 174
19 GO:0014900 muscle hyperplasia 1.288E-3 2.050E-2
1.329E-1
4.715E-1
 1 4
20 GO:0014805 smooth muscle adaptation 1.288E-3 2.050E-2
1.329E-1
4.715E-1
 1 4
21 GO:0070370 cellular heat acclimation 1.288E-3 2.050E-2
1.329E-1
4.715E-1
 1 4
22 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway 1.288E-3 2.050E-2
1.329E-1
4.715E-1
 1 4
23 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 1.288E-3 2.050E-2
1.329E-1
4.715E-1
 1 4
24 GO:0035966 response to topologically incorrect protein 1.419E-3 2.164E-2
1.402E-1
5.193E-1
 2 184
25 GO:0010286 heat acclimation 1.610E-3 2.266E-2
1.469E-1
5.893E-1
 1 5
26 GO:0007525 somatic muscle development 1.610E-3 2.266E-2
1.469E-1
5.893E-1
 1 5
27 GO:0003100 regulation of systemic arterial blood pressure by endothelin 1.932E-3 2.281E-2
1.478E-1
7.070E-1
 1 6
28 GO:0070309 lens fiber cell morphogenesis 1.932E-3 2.281E-2
1.478E-1
7.070E-1
 1 6
29 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1.932E-3 2.281E-2
1.478E-1
7.070E-1
 1 6
30 GO:0060700 regulation of ribonuclease activity 1.932E-3 2.281E-2
1.478E-1
7.070E-1
 1 6
31 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway 1.932E-3 2.281E-2
1.478E-1
7.070E-1
 1 6
32 GO:0090257 regulation of muscle system process 2.002E-3 2.289E-2
1.484E-1
7.326E-1
 2 219
33 GO:2001234 negative regulation of apoptotic signaling pathway 2.167E-3 2.356E-2
1.527E-1
7.932E-1
 2 228
34 GO:0070432 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 2.253E-3 2.356E-2
1.527E-1
8.248E-1
 1 7
35 GO:0006457 protein folding 2.320E-3 2.356E-2
1.527E-1
8.490E-1
 2 236
36 GO:0034599 cellular response to oxidative stress 2.537E-3 2.356E-2
1.527E-1
9.286E-1
 2 247
37 GO:0097191 extrinsic apoptotic signaling pathway 2.537E-3 2.356E-2
1.527E-1
9.286E-1
 2 247
38 GO:0003057 regulation of the force of heart contraction by chemical signal 2.575E-3 2.356E-2
1.527E-1
9.425E-1
 1 8
39 GO:0070141 response to UV-A 2.575E-3 2.356E-2
1.527E-1
9.425E-1
 1 8
40 GO:0014745 negative regulation of muscle adaptation 2.575E-3 2.356E-2
1.527E-1
9.425E-1
 1 8
41 GO:0000302 response to reactive oxygen species 2.639E-3 2.356E-2
1.527E-1
9.660E-1
 2 252
42 GO:1903896 positive regulation of IRE1-mediated unfolded protein response 2.897E-3 2.465E-2
1.598E-1
1.000E0
 1 9
43 GO:0098787 mRNA cleavage involved in mRNA processing 2.897E-3 2.465E-2
1.598E-1
1.000E0
 1 9
44 GO:0007021 tubulin complex assembly 3.218E-3 2.617E-2
1.696E-1
1.000E0
 1 10
45 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway 3.218E-3 2.617E-2
1.696E-1
1.000E0
 1 10
46 GO:0090084 negative regulation of inclusion body assembly 3.539E-3 2.699E-2
1.749E-1
1.000E0
 1 11
47 GO:0006527 arginine catabolic process 3.539E-3 2.699E-2
1.749E-1
1.000E0
 1 11
48 GO:0031284 positive regulation of guanylate cyclase activity 3.539E-3 2.699E-2
1.749E-1
1.000E0
 1 11
49 GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 3.860E-3 2.884E-2
1.869E-1
1.000E0
 1 12
50 GO:0001542 ovulation from ovarian follicle 4.182E-3 2.888E-2
1.872E-1
1.000E0
 1 13
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 19 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 3 input genes in category / 133 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 502 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 42 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001436 Alpha-crystallin/HSP InterPro 3.681E-13 1.012E-11 4.380E-11 1.546E-11 4 9
2 IPR002068 A-crystallin/Hsp20 dom InterPro 9.640E-13 1.012E-11 4.380E-11 4.049E-11 4 11
3 PF00011 HSP20 Pfam 9.640E-13 1.012E-11 4.380E-11 4.049E-11 4 11
4 PS01031 HSP20 PROSITE 9.640E-13 1.012E-11 4.380E-11 4.049E-11 4 11
5 IPR008978 HSP20-like chaperone InterPro 4.362E-11 3.664E-10 1.585E-9 1.832E-9 4 26
6 IPR031107 HSP20 InterPro 1.532E-9 1.072E-8 4.640E-8 6.434E-8 3 9
7 2.60.40.790 - Gene3D 3.225E-8 1.935E-7 8.371E-7 1.354E-6 3 23
8 IPR003090 Alpha-crystallin N InterPro 5.127E-7 2.393E-6 1.035E-5 2.153E-5 2 4
9 PF00525 Crystallin Pfam 5.127E-7 2.393E-6 1.035E-5 2.153E-5 2 4
10 IPR012274 Alpha-crystallin A InterPro 6.404E-4 2.445E-3 1.058E-2 2.690E-2 1 2
11 IPR012273 Alpha-crystallin B InterPro 6.404E-4 2.445E-3 1.058E-2 2.690E-2 1 2
12 IPR004030 NOS N InterPro 9.605E-4 2.521E-3 1.091E-2 4.034E-2 1 3
13 PF02898 NO synthase Pfam 9.605E-4 2.521E-3 1.091E-2 4.034E-2 1 3
14 3.90.340.10 - Gene3D 9.605E-4 2.521E-3 1.091E-2 4.034E-2 1 3
15 PS60001 NOS PROSITE 9.605E-4 2.521E-3 1.091E-2 4.034E-2 1 3
16 IPR012144 NOS euk InterPro 9.605E-4 2.521E-3 1.091E-2 4.034E-2 1 3
17 1.20.990.10 - Gene3D 1.920E-3 4.033E-3 1.745E-2
8.065E-2
 1 6
18 IPR003097 FAD-binding 1 InterPro 1.920E-3 4.033E-3 1.745E-2
8.065E-2
 1 6
19 PF00667 FAD binding 1 Pfam 1.920E-3 4.033E-3 1.745E-2
8.065E-2
 1 6
20 IPR023173 NADPH Cyt P450 Rdtase dom3 InterPro 1.920E-3 4.033E-3 1.745E-2
8.065E-2
 1 6
21 IPR008254 Flavodoxin/NO synth InterPro 2.560E-3 4.479E-3 1.938E-2
1.075E-1
 1 8
22 PS50902 FLAVODOXIN LIKE PROSITE 2.560E-3 4.479E-3 1.938E-2
1.075E-1
 1 8
23 IPR001094 Flavdoxin-like InterPro 2.560E-3 4.479E-3 1.938E-2
1.075E-1
 1 8
24 PF00258 Flavodoxin 1 Pfam 2.560E-3 4.479E-3 1.938E-2
1.075E-1
 1 8
25 3.40.50.360 - Gene3D 3.199E-3 4.976E-3 2.153E-2
1.343E-1
 1 10
26 IPR001709 Flavoprot Pyr Nucl cyt Rdtase InterPro 3.199E-3 4.976E-3 2.153E-2
1.343E-1
 1 10
27 IPR029039 Flavoprotein-like dom InterPro 3.199E-3 4.976E-3 2.153E-2
1.343E-1
 1 10
28 PF00175 NAD binding 1 Pfam 3.837E-3 5.135E-3 2.222E-2
1.612E-1
 1 12
29 IPR029047 HSP70 peptide-bd InterPro 3.837E-3 5.135E-3 2.222E-2
1.612E-1
 1 12
30 IPR001433 OxRdtase FAD/NAD-bd InterPro 3.837E-3 5.135E-3 2.222E-2
1.612E-1
 1 12
31 2.60.34.10 - Gene3D 3.837E-3 5.135E-3 2.222E-2
1.612E-1
 1 12
32 1.20.1270.10 - Gene3D 4.157E-3 5.135E-3 2.222E-2
1.746E-1
 1 13
33 IPR029048 HSP70 C InterPro 4.157E-3 5.135E-3 2.222E-2
1.746E-1
 1 13
34 IPR018181 Heat shock 70 CS InterPro 4.157E-3 5.135E-3 2.222E-2
1.746E-1
 1 13
35 PF00012 HSP70 Pfam 5.114E-3 6.005E-3 2.598E-2
2.148E-1
 1 16
36 PS00329 HSP70 2 PROSITE 5.433E-3 6.005E-3 2.598E-2
2.282E-1
 1 17
37 PS00297 HSP70 1 PROSITE 5.433E-3 6.005E-3 2.598E-2
2.282E-1
 1 17
38 PS01036 HSP70 3 PROSITE 5.433E-3 6.005E-3 2.598E-2
2.282E-1
 1 17
39 IPR013126 Hsp 70 fam InterPro 5.752E-3 6.070E-3 2.626E-2
2.416E-1
 1 18
40 IPR017927 Fd Rdtase FAD-bd InterPro 6.070E-3 6.070E-3 2.626E-2
2.550E-1
 1 19
41 PS51384 FAD FR PROSITE 6.070E-3 6.070E-3 2.626E-2
2.550E-1
 1 19
42 IPR017938 Riboflavin synthase-like b-brl InterPro 6.070E-3 6.070E-3 2.626E-2
2.550E-1
 1 19
Show 37 more annotations

7: Pathway [Display Chart] 4 input genes in category / 76 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00056 VEGF signaling pathway PantherDB 3.826E-7 2.907E-5 1.429E-4 2.907E-5 3 58
2 P00005 Angiogenesis PantherDB 6.797E-6 2.583E-4 1.269E-3 5.166E-4 3 150
3 1269122 Viral RNP Complexes in the Host Cell Nucleus BioSystems: REACTOME 3.213E-4 6.920E-3 3.401E-2 2.442E-2 1 1
4 799177 Estrogen signaling pathway BioSystems: KEGG 3.642E-4 6.920E-3 3.401E-2 2.768E-2 2 98
5 1270118 NOSIP mediated eNOS trafficking BioSystems: REACTOME 6.425E-4 9.766E-3 4.799E-2 4.883E-2 1 2
6 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 1.042E-3 1.320E-2
6.485E-2
7.918E-2
 2 166
7 585562 Epstein-Barr virus infection BioSystems: KEGG 1.553E-3 1.356E-2
6.664E-2
1.181E-1
 2 203
8 1270119 NOSTRIN mediated eNOS trafficking BioSystems: REACTOME 1.606E-3 1.356E-2
6.664E-2
1.220E-1
 1 5
9 703092 citrulline-nitric oxide cycle BioSystems: BIOCYC 1.606E-3 1.356E-2
6.664E-2
1.220E-1
 1 5
10 1270120 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation BioSystems: REACTOME 3.850E-3 2.541E-2
1.249E-1
2.926E-1
 1 12
11 1270117 eNOS activation BioSystems: REACTOME 3.850E-3 2.541E-2
1.249E-1
2.926E-1
 1 12
12 1270424 Attenuation phase BioSystems: REACTOME 4.811E-3 2.541E-2
1.249E-1
3.656E-1
 1 15
13 M2587 Stress Induction of HSP Regulation MSigDB C2 BIOCARTA (v6.0) 4.811E-3 2.541E-2
1.249E-1
3.656E-1
 1 15
14 M13324 Hypoxia-Inducible Factor in the Cardiovascular System MSigDB C2 BIOCARTA (v6.0) 4.811E-3 2.541E-2
1.249E-1
3.656E-1
 1 15
15 M9546 Chaperones modulate interferon Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 6.091E-3 2.541E-2
1.249E-1
4.629E-1
 1 19
16 M225 Downregulated of MTA-3 in ER-negative Breast Tumors MSigDB C2 BIOCARTA (v6.0) 6.091E-3 2.541E-2
1.249E-1
4.629E-1
 1 19
17 M10066 Corticosteroids and cardioprotection MSigDB C2 BIOCARTA (v6.0) 6.411E-3 2.541E-2
1.249E-1
4.872E-1
 1 20
18 82943 Arginine biosynthesis BioSystems: KEGG 6.731E-3 2.541E-2
1.249E-1
5.115E-1
 1 21
19 1270115 Metabolism of nitric oxide BioSystems: REACTOME 7.050E-3 2.541E-2
1.249E-1
5.358E-1
 1 22
20 1270116 eNOS activation and regulation BioSystems: REACTOME 7.050E-3 2.541E-2
1.249E-1
5.358E-1
 1 22
21 M5202 Hypoxia and p53 in the Cardiovascular system MSigDB C2 BIOCARTA (v6.0) 7.370E-3 2.541E-2
1.249E-1
5.601E-1
 1 23
22 1270423 HSF1-dependent transactivation BioSystems: REACTOME 7.370E-3 2.541E-2
1.249E-1
5.601E-1
 1 23
23 1269343 Nitric oxide stimulates guanylate cyclase BioSystems: REACTOME 7.689E-3 2.541E-2
1.249E-1
5.844E-1
 1 24
24 138009 Plasma membrane estrogen receptor signaling BioSystems: Pathway Interaction Database 8.328E-3 2.614E-2
1.285E-1
6.329E-1
 1 26
25 M12975 VEGF, Hypoxia, and Angiogenesis MSigDB C2 BIOCARTA (v6.0) 9.286E-3 2.614E-2
1.285E-1
7.057E-1
 1 29
26 1269484 VEGFR2 mediated vascular permeability BioSystems: REACTOME 9.286E-3 2.614E-2
1.285E-1
7.057E-1
 1 29
27 137924 VEGFR1 specific signals BioSystems: Pathway Interaction Database 9.286E-3 2.614E-2
1.285E-1
7.057E-1
 1 29
28 M4383 Actions of Nitric Oxide in the Heart MSigDB C2 BIOCARTA (v6.0) 9.924E-3 2.660E-2
1.307E-1
7.542E-1
 1 31
29 1269121 Export of Viral Ribonucleoproteins from Nucleus BioSystems: REACTOME 1.024E-2 2.660E-2
1.307E-1
7.785E-1
 1 32
30 1269138 ROS, RNS production in phagocytes BioSystems: REACTOME 1.056E-2 2.660E-2
1.307E-1
8.027E-1
 1 33
31 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 1.088E-2 2.660E-2
1.307E-1
8.269E-1
 1 34
32 101144 Prion diseases BioSystems: KEGG 1.120E-2 2.660E-2
1.307E-1
8.511E-1
 1 35
33 MAP00330 Arginine and proline metabolism MAP00330 Arginine and proline metabolism GenMAPP 1.215E-2 2.799E-2
1.376E-1
9.237E-1
 1 38
34 M862 p38 MAPK Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.279E-2 2.859E-2
1.405E-1
9.721E-1
 1 40
35 138060 Thromboxane A2 receptor signaling BioSystems: Pathway Interaction Database 1.438E-2 3.123E-2
1.535E-1
1.000E0
 1 45
36 P00048 PI3 kinase pathway PantherDB 1.533E-2 3.150E-2
1.548E-1
1.000E0
 1 48
37 137917 Angiopoietin receptor Tie2-mediated signaling BioSystems: Pathway Interaction Database 1.533E-2 3.150E-2
1.548E-1
1.000E0
 1 48
38 82957 Arginine and proline metabolism BioSystems: KEGG 1.597E-2 3.194E-2
1.570E-1
1.000E0
 1 50
39 469200 Legionellosis BioSystems: KEGG 1.756E-2 3.406E-2
1.674E-1
1.000E0
 1 55
40 M2404 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) MSigDB C2 BIOCARTA (v6.0) 1.851E-2 3.406E-2
1.674E-1
1.000E0
 1 58
41 83066 VEGF signaling pathway BioSystems: KEGG 1.882E-2 3.406E-2
1.674E-1
1.000E0
 1 59
42 1269726 AUF1 (hnRNP D0) binds and destabilizes mRNA BioSystems: REACTOME 1.882E-2 3.406E-2
1.674E-1
1.000E0
 1 59
43 1340713 Longevity regulating pathway - multiple species BioSystems: KEGG 1.977E-2 3.470E-2
1.705E-1
1.000E0
 1 62
44 137940 Signaling events mediated by VEGFR1 and VEGFR2 BioSystems: Pathway Interaction Database 2.009E-2 3.470E-2
1.705E-1
1.000E0
 1 63
45 1270425 Regulation of HSF1-mediated heat shock response BioSystems: REACTOME 2.230E-2 3.767E-2
1.851E-1
1.000E0
 1 70
46 P00019 Endothelin signaling pathway PantherDB 2.325E-2 3.841E-2
1.888E-1
1.000E0
 1 73
47 83074 Antigen processing and presentation BioSystems: KEGG 2.451E-2 3.964E-2
1.948E-1
1.000E0
 1 77
48 1270421 Cellular response to heat stress BioSystems: REACTOME 2.829E-2 4.404E-2
2.164E-1
1.000E0
 1 89
49 1269341 Platelet homeostasis BioSystems: REACTOME 2.892E-2 4.404E-2
2.164E-1
1.000E0
 1 91
50 P00036 Interleukin signaling pathway PantherDB 2.924E-2 4.404E-2
2.164E-1
1.000E0
 1 92
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 4153 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19464326 HSPB7 is a SC35 speckle resident small heat shock protein. Pubmed 2.132E-14 8.853E-11 7.887E-10 8.853E-11 4 9
2 17661394 Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Pubmed 1.209E-13 2.511E-10 2.237E-9 5.023E-10 4 13
3 21905118 Inhibition of α-synuclein aggregation by small heat shock proteins. Pubmed 4.307E-11 5.963E-8 5.312E-7 1.789E-7 3 6
4 19845507 Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Pubmed 6.170E-8 2.847E-5 2.536E-4 2.562E-4 2 3
5 28317868 HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway. Pubmed 6.170E-8 2.847E-5 2.536E-4 2.562E-4 2 3
6 27570075 A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism. Pubmed 6.170E-8 2.847E-5 2.536E-4 2.562E-4 2 3
7 17438522 alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
8 23590631 Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
9 11157875 Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
10 23188086 Binding determinants of the small heat shock protein, αB-crystallin: recognition of the 'IxI' motif. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
11 16675842 Alpha-crystallin expression affects microtubule assembly and prevents their aggregation. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
12 12546709 Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
13 18384969 Expression of the small heat shock protein family in the mouse CNS: differential anatomical and biochemical compartmentalization. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
14 26694816 Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
15 16225851 Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
16 18191123 Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
17 28181153 An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
18 14594798 Interaction of human HSP22 (HSPB8) with other small heat shock proteins. Pubmed 1.234E-7 2.847E-5 2.536E-4 5.124E-4 2 4
19 16439475 Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice. Pubmed 2.056E-7 3.882E-5 3.458E-4 8.540E-4 2 5
20 17893660 Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice. Pubmed 2.056E-7 3.882E-5 3.458E-4 8.540E-4 2 5
21 20959464 Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis. Pubmed 2.056E-7 3.882E-5 3.458E-4 8.540E-4 2 5
22 21731611 HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes. Pubmed 2.056E-7 3.882E-5 3.458E-4 8.540E-4 2 5
23 11342557 HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27). Pubmed 3.084E-7 5.569E-5 4.961E-4 1.281E-3 2 6
24 12601044 Alteration of protein-protein interactions of congenital cataract crystallin mutants. Pubmed 4.318E-7 7.471E-5 6.656E-4 1.793E-3 2 7
25 18675797 Eye formation in the absence of retina. Pubmed 7.400E-7 1.229E-4 1.095E-3 3.073E-3 2 9
26 11714668 The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Pubmed 1.130E-6 1.806E-4 1.609E-3 4.695E-3 2 11
27 11304494 Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Pubmed 1.356E-6 2.086E-4 1.859E-3 5.633E-3 2 12
28 10603348 Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Pubmed 3.143E-6 3.696E-4 3.293E-3 1.305E-2 2 18
29 27483141 Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction. Pubmed 6.160E-6 3.696E-4 3.293E-3 2.558E-2 2 25
30 12082592 Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. Pubmed 3.626E-5 3.696E-4 3.293E-3
1.506E-1
 2 60
31 18977241 Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Pubmed 1.384E-4 3.696E-4 3.293E-3
5.750E-1
 2 117
32 17601350 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Pubmed 1.432E-4 3.696E-4 3.293E-3
5.948E-1
 2 119
33 22496890 Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Pubmed 1.505E-4 3.696E-4 3.293E-3
6.252E-1
 2 122
34 24019403 Target sequencing, cell experiments, and a population study establish endothelial nitric oxide synthase (eNOS) gene as hypertension susceptibility gene. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
35 22542467 Cardiac H11 kinase/Hsp22 stimulates oxidative phosphorylation and modulates mitochondrial reactive oxygen species production: Involvement of a nitric oxide-dependent mechanism. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
36 18575589 Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
37 28946141 The Endothelial Nitric Oxide Synthase Gene Polymorphism is Associated with the Susceptibility to Immunoglobulin a Nephropathy in Chinese Population. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
38 12573525 Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
39 20810793 Endothelial nitric oxide synthase gene variation associated with chronic kidney disease after liver transplant. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
40 16368881 Red blood cells express a functional endothelial nitric oxide synthase. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
41 21963726 Endothelial nitric oxide synthase G894T gene polymorphism and essential hypertension in the Chinese population: a meta-analysis involving 11,248 subjects. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
42 12473258 The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
43 18495009 Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
44 3789668 A rapidly progressive autosomal dominant scapulohumeral form of spinal muscular atrophy. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
45 15476407 Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
46 21687995 The 894G>T endothelial nitric oxide synthase genetic polymorphism affects hemodynamic responses to mental stress performed before and after exercise. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
47 16377020 Association of the endothelial nitric oxide synthase (ecNOS) gene polymorphism with carotid atherosclerosis in type 2 diabetes. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
48 25018622 Comparison of effect of gamma ray irradiation on wild-type and N-terminal mutants of αA-crystallin. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
49 12456486 H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
50 19255933 A family-based study does not support the association of a functional polymorphism in the gene for endothelial nitric oxide synthase with risk for rheumatoid arthritis. Pubmed 1.571E-4 3.696E-4 3.293E-3
6.524E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 506 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:HSPB8 HSPB8 interactions 1.538E-7 7.783E-5 5.296E-4 7.783E-5 3 36
2 int:SNCA SNCA interactions 3.353E-7 8.482E-5 5.772E-4 1.696E-4 4 219
3 int:CRYGC CRYGC interactions 3.443E-6 5.613E-4 3.819E-3 1.742E-3 2 9
4 int:HSPB6 HSPB6 interactions 5.258E-6 5.613E-4 3.819E-3 2.661E-3 2 11
5 int:CRYAB CRYAB interactions 5.546E-6 5.613E-4 3.819E-3 2.806E-3 3 117
6 int:HSPB2 HSPB2 interactions 1.502E-5 1.033E-3 7.028E-3 7.599E-3 3 163
7 int:HSPB3 HSPB3 interactions 1.633E-5 1.033E-3 7.028E-3 8.262E-3 2 19
8 int:CRYAA CRYAA interactions 1.633E-5 1.033E-3 7.028E-3 8.262E-3 2 19
9 int:ST13 ST13 interactions 1.072E-4 6.029E-3 4.103E-2
5.426E-2
 2 48
10 int:DNAJB6 DNAJB6 interactions 2.354E-4 1.191E-2
8.106E-2
1.191E-1
 2 71
11 int:TXNIP TXNIP interactions 2.627E-4 1.209E-2
8.224E-2
1.329E-1
 2 75
12 int:HSPB1 HSPB1 interactions 2.923E-4 1.233E-2
8.387E-2
1.479E-1
 3 442
13 int:BAG3 BAG3 interactions 3.637E-4 1.415E-2
9.632E-2
1.840E-1
 3 476
14 int:BEX4 BEX4 interactions 6.778E-4 2.303E-2
1.567E-1
3.429E-1
 1 2
15 int:A2M A2M interactions 6.826E-4 2.303E-2
1.567E-1
3.454E-1
 2 121
16 int:HSF1 HSF1 interactions 7.754E-4 2.416E-2
1.644E-1
3.923E-1
 2 129
17 int:AIFM1 AIFM1 interactions 8.116E-4 2.416E-2
1.644E-1
4.107E-1
 2 132
18 int:UQCRHL UQCRHL interactions 1.016E-3 2.572E-2
1.750E-1
5.143E-1
 1 3
19 int:SLC5A1 SLC5A1 interactions 1.016E-3 2.572E-2
1.750E-1
5.143E-1
 1 3
20 int:AGAP11 AGAP11 interactions 1.016E-3 2.572E-2
1.750E-1
5.143E-1
 1 3
21 int:SLC25A42 SLC25A42 interactions 1.355E-3 2.857E-2
1.944E-1
6.857E-1
 1 4
22 int:DNAJB7 DNAJB7 interactions 1.355E-3 2.857E-2
1.944E-1
6.857E-1
 1 4
23 int:CRYGD CRYGD interactions 1.355E-3 2.857E-2
1.944E-1
6.857E-1
 1 4
24 int:THEMIS2 THEMIS2 interactions 1.355E-3 2.857E-2
1.944E-1
6.857E-1
 1 4
25 int:PLIN4 PLIN4 interactions 1.694E-3 2.857E-2
1.944E-1
8.570E-1
 1 5
26 int:CPT1B CPT1B interactions 1.694E-3 2.857E-2
1.944E-1
8.570E-1
 1 5
27 int:RNF207 RNF207 interactions 1.694E-3 2.857E-2
1.944E-1
8.570E-1
 1 5
28 int:NOSTRIN NOSTRIN interactions 1.694E-3 2.857E-2
1.944E-1
8.570E-1
 1 5
29 int:CYP1B1 CYP1B1 interactions 1.694E-3 2.857E-2
1.944E-1
8.570E-1
 1 5
30 int:CRAT CRAT interactions 1.694E-3 2.857E-2
1.944E-1
8.570E-1
 1 5
31 int:LAMA2 LAMA2 interactions 2.032E-3 2.926E-2
1.991E-1
1.000E0
 1 6
32 int:MAOB MAOB interactions 2.032E-3 2.926E-2
1.991E-1
1.000E0
 1 6
33 int:CACNA1E CACNA1E interactions 2.032E-3 2.926E-2
1.991E-1
1.000E0
 1 6
34 int:CRYBB2 CRYBB2 interactions 2.032E-3 2.926E-2
1.991E-1
1.000E0
 1 6
35 int:GATD3B GATD3B interactions 2.032E-3 2.926E-2
1.991E-1
1.000E0
 1 6
36 int:MYOM2 MYOM2 interactions 2.370E-3 2.926E-2
1.991E-1
1.000E0
 1 7
37 int:THUMPD2 THUMPD2 interactions 2.370E-3 2.926E-2
1.991E-1
1.000E0
 1 7
38 int:ABCC9 ABCC9 interactions 2.370E-3 2.926E-2
1.991E-1
1.000E0
 1 7
39 int:APOO APOO interactions 2.370E-3 2.926E-2
1.991E-1
1.000E0
 1 7
40 int:CRYBA1 CRYBA1 interactions 2.370E-3 2.926E-2
1.991E-1
1.000E0
 1 7
41 int:LALBA LALBA interactions 2.370E-3 2.926E-2
1.991E-1
1.000E0
 1 7
42 int:ATP5F1A ATP5F1A interactions 2.436E-3 2.934E-2
1.997E-1
1.000E0
 2 230
43 int:MB MB interactions 2.709E-3 3.046E-2
2.073E-1
1.000E0
 1 8
44 int:OGDHL OGDHL interactions 2.709E-3 3.046E-2
2.073E-1
1.000E0
 1 8
45 int:AUH AUH interactions 2.709E-3 3.046E-2
2.073E-1
1.000E0
 1 8
46 int:MT-CO3 MT-CO3 interactions 3.047E-3 3.352E-2
2.281E-1
1.000E0
 1 9
47 int:CDC37 CDC37 interactions 3.147E-3 3.380E-2
2.300E-1
1.000E0
 2 262
48 int:SNRK SNRK interactions 3.385E-3 3.380E-2
2.300E-1
1.000E0
 1 10
49 int:EXPH5 EXPH5 interactions 3.385E-3 3.380E-2
2.300E-1
1.000E0
 1 10
50 int:PRKCA PRKCA interactions 3.636E-3 3.380E-2
2.300E-1
1.000E0
 2 282
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q22-q23 11q22-q23 1.038E-3 6.230E-3 1.526E-2 6.230E-3 1 6
2 12q24.23 12q24.23 3.457E-3 9.330E-3 2.286E-2 2.074E-2 1 20
3 7q36 7q36 4.665E-3 9.330E-3 2.286E-2 2.799E-2 1 27
4 19q13.12 19q13.12 1.274E-2 1.911E-2 4.683E-2
7.646E-2
 1 74
5 21q22.3 21q22.3 2.348E-2 2.818E-2
6.904E-2
1.409E-1
 1 137
6 6p21.3 6p21.3 4.367E-2 4.367E-2
1.070E-1
2.620E-1
 1 257
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 63 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$HSF2 01 V$HSF2 01 7.837E-5 4.938E-3 2.335E-2 4.938E-3 3 197
2 RGAANNTTC V$HSF1 01 RGAANNTTC V$HSF1 01 4.505E-4 1.419E-2
6.709E-2
 2.838E-2 3 355
3 TTCNRGNNNNTTC V$HSF Q6 TTCNRGNNNNTTC V$HSF Q6 1.389E-3 2.916E-2
1.379E-1
8.749E-2
 2 117
4 V$HSF Q6 V$HSF Q6 2.332E-3 3.673E-2
1.736E-1
1.469E-1
 2 152

12: Gene Family [Display Chart] 5 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 585 Small heat shock proteins genenames.org 3.614E-13 1.084E-12 1.988E-12 1.084E-12 4 11
2 583 Heat shock 70kDa proteins genenames.org 4.664E-3 6.995E-3 1.283E-2 1.399E-2 1 17
3 694 Protein phosphatase 1 regulatory subunits genenames.org 4.877E-2 4.877E-2
8.941E-2
1.463E-1
 1 181

13: Coexpression [Display Chart] 6 input genes in category / 578 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19286929-SuppTable2o Mouse Lung Rangasamy09 12genes GeneSigDB 3.079E-6 1.237E-3 8.580E-3 1.780E-3 2 11
2 15642130-TableS1b Rat Immune Rioja04 188genes GeneSigDB 4.279E-6 1.237E-3 8.580E-3 2.474E-3 3 140
3 M8465 Genes down-regulated in activated CD4 [GeneID=920] T cells: wildtype versus over-expressing MIR17 [GeneID=406952]. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.804E-3 1.252E-2 7.216E-3 3 200
4 M9689 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 10h versus 30h. MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 1.804E-3 1.252E-2 7.216E-3 3 200
5 M2340 Top genes up-regulated in HEK293 cells (fibroblast) in response to trichostatin A (TSA) [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.268E-5 2.622E-3 1.819E-2 1.311E-2 2 29
6 18787207-TableS1 Mouse Viral Craft08 69genes GeneSigDB 5.521E-5 4.559E-3 3.163E-2 3.191E-2 2 45
7 17714734-Table4 Human pancreas Yang09 44genes GeneSigDB 5.521E-5 4.559E-3 3.163E-2 3.191E-2 2 45
8 18787207-Table1 Mouse Viral Craft08 83genes GeneSigDB 1.501E-4 9.973E-3
6.919E-2
8.677E-2
 2 74
9 17638894-Table2 Mouse Breast Piechocki07 87genes GefitinibSensitiveResistant GeneSigDB 1.584E-4 9.973E-3
6.919E-2
9.154E-2
 2 76
10 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 1.725E-4 9.973E-3
6.919E-2
9.973E-2
 3 483
11 15885264-Table1 Mouse Lung not cancer Lee05 127genes GeneSigDB 3.140E-4 1.650E-2
1.145E-1
1.815E-1
 2 107
12 M11672 Genes from the blue module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.992E-4 2.404E-2
1.668E-1
2.885E-1
 2 135
13 M2758 Genes down-regulated in HCT116 cells (colon carcinoma) upon knockdown of PTEN [Gene ID=5728] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 5.598E-4 2.423E-2
1.681E-1
3.236E-1
 2 143
14 11282888-SuppTable3 Human Lung not cancer Geraci01 4genes GeneSigDB 1.037E-3 2.423E-2
1.681E-1
5.994E-1
 1 4
15 M12824 Cluster 4 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts good survival outcome. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.047E-3 2.423E-2
1.681E-1
6.053E-1
 2 196
16 M8159 Genes up-regulated in HEK293 cells at 6h after stimulation by muramyl dipeptide [PubChem=11620162]: over-expressing wildtype NOD2 [GeneID=64127] versus control. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.423E-2
1.681E-1
6.115E-1
 2 197
17 M7568 Genes down-regulated in CD11b+ cells from BALB/c mice: spleen versus bone marrow. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.423E-2
1.681E-1
6.115E-1
 2 197
18 M7139 Genes down-regulated in CD8A- [GeneID=925] splenic dendritic cells: wildtype versus IFNAR1 [GeneID=3454] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 2.423E-2
1.681E-1
6.176E-1
 2 198
19 M3189 Genes up-regulated in comparison of IgD+ peripheral blood B cells versus dark zone germincal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.423E-2
1.681E-1
6.238E-1
 2 199
20 M3187 Genes up-regulated in comparison of IgD+ B cells from peripheral blood versus CD19 pre-germinal center tonsil B cell MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.423E-2
1.681E-1
6.238E-1
 2 199
21 M3850 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.423E-2
1.681E-1
6.301E-1
 2 200
22 M9637 Genes down-regulated in CD4 [GeneID=920] T helper cells (1h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.423E-2
1.681E-1
6.301E-1
 2 200
23 M5241 Genes up-regulated in comparison of macrophages exposed to L. donovani versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.423E-2
1.681E-1
6.301E-1
 2 200
24 M7471 Genes up-regulated in CD4 [GeneID=920] T cells: medium versus TGF beta. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.423E-2
1.681E-1
6.301E-1
 2 200
25 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 2.423E-2
1.681E-1
6.301E-1
 2 200
26 M5181 Genes up-regulated in comparison of dendritic cells exposed to L. major versus macrophages exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.423E-2
1.681E-1
6.301E-1
 2 200
27 M1098 Genes down-regulated in ME-A cells (breast cancer) undergoing apoptosis upon serum starvation (5% to 0% FCS) for 22 hr. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.487E-3 3.184E-2
2.209E-1
8.597E-1
 2 234
28 15173083-Table3 Human Brain Levy04 12genes GeneSigDB 2.073E-3 3.994E-2
2.771E-1
1.000E0
 1 8
29 M1265 Selected genes up-regulated in Rat1Ras cells (fibroblasts) which were transformed by expression of an oncogenic activated form of HRAS [GeneID=3265] compared to the parental Rat1 cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.073E-3 3.994E-2
2.771E-1
1.000E0
 1 8
30 16585964-SuppTable5 Mouse Lung not cancer Thimmulappa06 15genes GeneSigDB 2.073E-3 3.994E-2
2.771E-1
1.000E0
 1 8
31 M1338 Genes commonly up-regulated in both non-tumorous and tumorous liver tissues of PARK2 [GeneID=5071] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.591E-3 4.538E-2
3.148E-1
1.000E0
 1 10
32 16529784-Table6 Rat Lung not cancer Gate06 12genes GeneSigDB 2.591E-3 4.538E-2
3.148E-1
1.000E0
 1 10
33 M4000 Protein kinase genes most significantly up-regulated in ASPS (alveolar soft part sarcoma) tumors compared to four other types of primitive sarcomas. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.591E-3 4.538E-2
3.148E-1
1.000E0
 1 10
34 M2504 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.052E-3 4.856E-2
3.369E-1
1.000E0
 2 337
35 M7700 Genes up-regulated in hepatocellular carcinoma (HCC) with early recurrence. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.108E-3 4.856E-2
3.369E-1
1.000E0
 1 12
36 17895889-Table1a Human Leukemia Hamamura07 12genes GeneSigDB 3.108E-3 4.856E-2
3.369E-1
1.000E0
 1 12
37 M15228 Genes up-regulated in naive T lymphocytes lacking FURIN [GeneID=5045]: Cre-Lox knockout of FURIN in CD4+ [GeneID=920] cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.108E-3 4.856E-2
3.369E-1
1.000E0
 1 12
38 M2576 Genes consistently down-regulated in mammary luminal progenitor cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.625E-3 4.989E-2
3.461E-1
1.000E0
 1 14
39 19026495-table1 Human Prostate Alonso09 16genes GeneSigDB 3.625E-3 4.989E-2
3.461E-1
1.000E0
 1 14
40 18593933-Table1a Human Lung Magda08 21genes GeneSigDB 3.625E-3 4.989E-2
3.461E-1
1.000E0
 1 14
41 17304115-Figure4 Rat Lung not cancer Colombo06 17genes GeneSigDB 3.625E-3 4.989E-2
3.461E-1
1.000E0
 1 14
42 M1807 Genes important for ovulation, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.625E-3 4.989E-2
3.461E-1
1.000E0
 1 14
Show 37 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 549 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 200 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.190E-6 3.333E-3 2.295E-2 4.497E-3 3 164
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/cardiac muscle cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/cardiac muscle cell Tabula Muris Consortium 1.214E-5 3.333E-3 2.295E-2 6.665E-3 3 187
3 PCBC ratio SC blastocyst vs SC cord blood cfr-2X-p05 SC blastocyst vs SC cord blood-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.644E-5 8.376E-3
5.768E-2
 2.550E-2 2 39
4 gudmap kidney single cell adult JuxtaGlomCell Ren1Gfp Scamp k3 1000 kidney single cell adult JuxtaGlomCell Ren1Gfp StemCellamp k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.200E-5 8.376E-3
5.768E-2
 3.404E-2 2 45
5 gudmap developingLowerUrinaryTract adult bladder 500 DevelopingLowerUrinaryTract adult bladder emap-29457 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.989E-5 8.376E-3
5.768E-2
5.484E-2
 3 379
6 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.071E-4 8.376E-3
5.768E-2
5.880E-2
 3 388
7 gudmap developingLowerUrinaryTract P1 bladder 500 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.087E-4 8.376E-3
5.768E-2
5.970E-2
 3 390
8 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/1 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/1 TCGA-Prostate 1.220E-4 8.376E-3
5.768E-2
6.701E-2
 2 63
9 Facebase ST1 Univ 500 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 FaceBase_ST1 1.423E-4 8.678E-3
5.976E-2
7.811E-2
 3 427
10 Facebase ST1 e10.5 ColumEpith Maxil 100 e10.5 ColumEpith Maxil top-relative-expression-ranked 100 FaceBase_ST1 2.020E-4 1.091E-2
7.514E-2
1.109E-1
 2 81
11 PCBC ctl geo-heart 500 geo heart top-relative-expression-ranked 500 PCBC 2.256E-4 1.091E-2
7.514E-2
1.238E-1
 3 499
12 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 100 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.385E-4 1.091E-2
7.514E-2
1.309E-1
 2 88
13 gudmap developingLowerUrinaryTract adult bladder 500 k4 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.525E-4 1.489E-2
1.025E-1
1.935E-1
 2 107
14 geo heart 500 K4 geo heart top-relative-expression-ranked 500 k-means-cluster#4 PCBC 6.109E-4 2.300E-2
1.584E-1
3.354E-1
 2 141
15 JC fibro 1000 K2 JC fibro top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 6.283E-4 2.300E-2
1.584E-1
3.449E-1
 2 143
16 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/4 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/4 TCGA-Liver 7.002E-4 2.382E-2
1.640E-1
3.844E-1
 2 151
17 Facebase ST1 e10.5 ColumEpith Maxil 250 e10.5 ColumEpith Maxil top-relative-expression-ranked 250 FaceBase_ST1 7.661E-4 2.382E-2
1.640E-1
4.206E-1
 2 158
18 gudmap developingLowerUrinaryTract P1 bladder 200 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.052E-4 2.382E-2
1.640E-1
4.420E-1
 2 162
19 Facebase ST1 e9.5 NeuroEpith OverFaceMesench 500 4 e9.5 NeuroEpith OverFaceMesench top-relative-expression-ranked 500 4 FaceBase_ST1 8.244E-4 2.382E-2
1.640E-1
4.526E-1
 1 3
20 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Cbr2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Cbr2 BrainMap 8.860E-4 2.432E-2
1.675E-1
4.864E-1
 2 170
21 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/5 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/5 TCGA-Esophagus 9.599E-4 2.475E-2
1.704E-1
5.270E-1
 2 177
22 gudmap developingLowerUrinaryTract P1 ureter 1000 k2 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.037E-3 2.475E-2
1.704E-1
5.691E-1
 2 184
23 gudmap developingKidney e15.5 Ureteral Smooth Musc 500 k5 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.070E-3 2.475E-2
1.704E-1
5.877E-1
 2 187
24 Sample Type by Project: Shred 1/TCGA-Brain/Glioblastoma/Primary GBM/0/0 Sample Type by Project: Shred 1/TCGA-Brain/Glioblastoma/Primary GBM/0/0 TCGA-Brain 1.082E-3 2.475E-2
1.704E-1
5.939E-1
 2 188
25 gudmap developingLowerUrinaryTract P1 bladder B 1000 k1 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.128E-3 2.477E-2
1.706E-1
6.192E-1
 2 192
26 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 1.297E-3 2.641E-2
1.819E-1
7.119E-1
 2 206
27 PCBC ratio MESO-30 from-ESC vs MESO-30 from-episomal cfr-2X-p05 Mesoderm Day 30-method NA vs Mesoderm Day 30-method episomal-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.347E-3 2.641E-2
1.819E-1
7.395E-1
 2 210
28 PCBC ratio MESO-30 from-ESC vs MESO-30 from-OSK-L-l-p53KD cfr-2X-p05 Mesoderm Day 30-reprogram NA vs Mesoderm Day 30-reprogram OSK-L-l-p53KD-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.347E-3 2.641E-2
1.819E-1
7.395E-1
 2 210
29 Facebase ST1 Univ 500 4 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 4 FaceBase_ST1 1.411E-3 2.671E-2
1.840E-1
7.747E-1
 2 215
30 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k1 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.797E-3 3.289E-2
2.265E-1
9.868E-1
 2 243
31 gudmap developingLowerUrinaryTract P1 bladder J 1000 k2 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.916E-3 3.393E-2
2.337E-1
1.000E0
 2 251
32 gudmap kidney adult GlomCapSys Tie2 k1 1000 kidney adult GlomCapSys Tie2 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.213E-3 3.681E-2
2.535E-1
1.000E0
 2 270
33 gudmap developingKidney e15.5 Ureteral Smooth Musc 1000 k2 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.213E-3 3.681E-2
2.535E-1
1.000E0
 2 270
34 Facebase ST1 e10.5 ColumEpith Maxil 500 e10.5 ColumEpith Maxil top-relative-expression-ranked 500 FaceBase_ST1 2.444E-3 3.755E-2
2.586E-1
1.000E0
 2 284
35 gudmap kidney single cell adult JuxtaGlomCell Ren1Gfp Scamp 500 kidney single cell adult JuxtaGlomCell Ren1Gfp StemCellamp top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.495E-3 3.755E-2
2.586E-1
1.000E0
 2 287
36 BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1.Cdkn1c Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1.Cdkn1c Top 200 Genes BrainMap 2.547E-3 3.755E-2
2.586E-1
1.000E0
 2 290
37 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Stalk Subtype Flt1.Cdkn1c Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Stalk Subtype Flt1.Cdkn1c Top 200 Genes 2.547E-3 3.755E-2
2.586E-1
1.000E0
 2 290
38 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Cnn1 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Cnn1 Top 200 Genes 2.599E-3 3.755E-2
2.586E-1
1.000E0
 2 293
39 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Stalk Subtype Flt1.Mgp Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Endothelial Stalk Subtype Flt1.Mgp Top 200 Genes 2.849E-3 3.815E-2
2.627E-1
1.000E0
 2 307
40 geo heart 1000 K2 geo heart top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 2.849E-3 3.815E-2
2.627E-1
1.000E0
 2 307
41 BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1.Mgp Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1.Mgp Top 200 Genes BrainMap 2.849E-3 3.815E-2
2.627E-1
1.000E0
 2 307
42 BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5.Cnn1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5.Cnn1 Top 200 Genes BrainMap 3.167E-3 4.140E-2
2.851E-1
1.000E0
 2 324
43 Facebase ST1 e10.5 ColumEpith Mandib 500 e10.5 ColumEpith Mandib top-relative-expression-ranked 500 FaceBase_ST1 3.644E-3 4.540E-2
3.127E-1
1.000E0
 2 348
44 Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte F PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte F PND01-03 Top 200 Genes 3.644E-3 4.540E-2
3.127E-1
1.000E0
 2 348
45 JC fibro 2500 K3 JC fibro top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 3.852E-3 4.540E-2
3.127E-1
1.000E0
 2 358
46 Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte F Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte F Top 200 Genes 3.873E-3 4.540E-2
3.127E-1
1.000E0
 2 359
47 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 100 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 4.116E-3 4.540E-2
3.127E-1
1.000E0
 1 15
48 gudmap kidney single cell adult JuxtaGlomCell Ren1Gfp Scamp k3 100 kidney single cell adult JuxtaGlomCell Ren1Gfp StemCellamp k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.116E-3 4.540E-2
3.127E-1
1.000E0
 1 15
49 PCBC ratio MESO-30 blastocyst vs MESO-30 fibroblast cfr-2X-p05 MESO-30 blastocyst vs MESO-30 fibroblast-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.218E-3 4.540E-2
3.127E-1
1.000E0
 2 375
50 PCBC ratio MESO-30 from-ESC vs MESO-30 from-OSKM - NLT cfr-2X-p05 Mesoderm Day 30-reprogram NA vs Mesoderm Day 30-reprogram OSKM - NLT-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.218E-3 4.540E-2
3.127E-1
1.000E0
 2 375
Show 45 more annotations

15: Computational [Display Chart] 4 input genes in category / 33 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3336 MORF LTK Neighborhood of LTK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.254E-3 1.911E-2
7.814E-2
 4.138E-2 2 147
2 M1006 MORF RAGE Neighborhood of RAGE MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.271E-3 1.911E-2
7.814E-2
 4.194E-2 2 148
3 M2430 MORF RBBP8 Neighborhood of RBBP8 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.615E-3 1.911E-2
7.814E-2
8.629E-2
 2 213
4 M19723 MORF BCL2 Neighborhood of BCL2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.838E-3 1.911E-2
7.814E-2
9.364E-2
 2 222
5 M6229 MORF FDXR Neighborhood of FDXR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.939E-3 1.911E-2
7.814E-2
9.700E-2
 2 226
6 M15921 MORF MT4 Neighborhood of MT4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.475E-3 1.911E-2
7.814E-2
1.147E-1
 2 246
7 M18296 MORF TNFRSF25 Neighborhood of TNFRSF25 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.113E-3 1.939E-2
7.928E-2
1.357E-1
 2 268
8 M5502 MODULE 371 Genes in the cancer module 371. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.032E-2 3.307E-2
1.352E-1
3.407E-1
 1 26
9 M14348 MODULE 226 Genes in the cancer module 226. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.072E-2 3.307E-2
1.352E-1
3.537E-1
 1 27
10 M15268 MODULE 281 Phosphatase regulators. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.111E-2 3.307E-2
1.352E-1
3.668E-1
 1 28
11 M4563 MODULE 355 Protein folding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.151E-2 3.307E-2
1.352E-1
3.798E-1
 1 29
12 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.202E-2 3.307E-2
1.352E-1
3.968E-1
 2 464
13 M4634 MODULE 299 Genes in the cancer module 299. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.388E-2 3.523E-2
1.440E-1
4.580E-1
 1 35
14 M15255 MODULE 287 Genes in the cancer module 287. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.978E-2 4.663E-2
1.906E-1
6.528E-1
 1 50
Show 9 more annotations

16: MicroRNA [Display Chart] 6 input genes in category / 91 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-886-3p:mirSVR lowEffct hsa-miR-886-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.306E-4 2.918E-2
1.486E-1
5.739E-2
 2 473
2 hsa-miR-4284:mirSVR highEffct hsa-miR-4284:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.413E-4 2.918E-2
1.486E-1
5.835E-2
 2 477
3 hsa-miR-656-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.406E-3 3.278E-2
1.670E-1
2.190E-1
 1 29
4 hsa-miR-1231:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.732E-3 3.278E-2
1.670E-1
3.396E-1
 1 45
5 hsa-miR-6735-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 3.278E-2
1.670E-1
3.622E-1
 1 48
6 hsa-miR-4491:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.278E-2
1.670E-1
5.504E-1
 1 73
7 hsa-miR-4657:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.278E-2
1.670E-1
5.504E-1
 1 73
8 hsa-miR-4682:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 3.278E-2
1.670E-1
5.579E-1
 1 74
9 hsa-miR-29b-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.278E-2
1.670E-1
5.654E-1
 1 75
10 hsa-miR-4424:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.278E-2
1.670E-1
5.654E-1
 1 75
11 hsa-miR-6833-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.535E-3 3.278E-2
1.670E-1
6.856E-1
 1 91
12 hsa-miR-675:mirSVR highEffct hsa-miR-675:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.700E-3 3.278E-2
1.670E-1
7.007E-1
 1 93
13 hsa-miR-6742-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.112E-3 3.278E-2
1.670E-1
7.382E-1
 1 98
14 hsa-miR-1296-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.195E-3 3.278E-2
1.670E-1
7.457E-1
 1 99
15 hsa-miR-595:Functional MTI Functional MTI miRTarbase 8.360E-3 3.278E-2
1.670E-1
7.607E-1
 1 101
16 hsa-miR-6811-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.772E-3 3.278E-2
1.670E-1
7.982E-1
 1 106
17 hsa-miR-6511b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.854E-3 3.278E-2
1.670E-1
8.057E-1
 1 107
18 hsa-miR-543:Functional MTI Functional MTI miRTarbase 8.854E-3 3.278E-2
1.670E-1
8.057E-1
 1 107
19 hsa-miR-99a*:mirSVR highEffct hsa-miR-99a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.514E-3 3.278E-2
1.670E-1
8.658E-1
 1 115
20 hsa-miR-496:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.009E-2 3.278E-2
1.670E-1
9.182E-1
 1 122
21 hsa-miR-6132:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.058E-2 3.278E-2
1.670E-1
9.632E-1
 1 128
22 hsa-miR-6836-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.058E-2 3.278E-2
1.670E-1
9.632E-1
 1 128
23 hsa-miR-577:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.067E-2 3.278E-2
1.670E-1
9.707E-1
 1 129
24 hsa-miR-6079:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.067E-2 3.278E-2
1.670E-1
9.707E-1
 1 129
25 hsa-miR-99b*:mirSVR highEffct hsa-miR-99b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.075E-2 3.278E-2
1.670E-1
9.782E-1
 1 130
26 hsa-miR-194-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.091E-2 3.278E-2
1.670E-1
9.931E-1
 1 132
27 hsa-miR-3170:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.190E-2 3.278E-2
1.670E-1
1.000E0
 1 144
28 hsa-miR-6855-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.190E-2 3.278E-2
1.670E-1
1.000E0
 1 144
29 hsa-miR-4645-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.198E-2 3.278E-2
1.670E-1
1.000E0
 1 145
30 hsa-miR-4673:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.215E-2 3.278E-2
1.670E-1
1.000E0
 1 147
31 hsa-miR-6828-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.231E-2 3.278E-2
1.670E-1
1.000E0
 1 149
32 hsa-miR-629:PITA hsa-miR-629:PITA TOP PITA 1.264E-2 3.278E-2
1.670E-1
1.000E0
 1 153
33 hsa-miR-503:mirSVR highEffct hsa-miR-503:mirSVR conserved highEffect-0.5 MicroRNA.org 1.281E-2 3.278E-2
1.670E-1
1.000E0
 1 155
34 hsa-miR-3120-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.289E-2 3.278E-2
1.670E-1
1.000E0
 1 156
35 hsa-miR-3190-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.289E-2 3.278E-2
1.670E-1
1.000E0
 1 156
36 hsa-miR-671-5p:Functional MTI Functional MTI miRTarbase 1.297E-2 3.278E-2
1.670E-1
1.000E0
 1 157
37 hsa-miR-521:mirSVR highEffct hsa-miR-521:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.478E-2 3.407E-2
1.735E-1
1.000E0
 1 179
38 hsa-miR-6722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.494E-2 3.407E-2
1.735E-1
1.000E0
 1 181
39 hsa-miR-1909-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.510E-2 3.407E-2
1.735E-1
1.000E0
 1 183
40 hsa-miR-1307:mirSVR lowEffct hsa-miR-1307:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.527E-2 3.407E-2
1.735E-1
1.000E0
 1 185
41 hsa-miR-6783-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.535E-2 3.407E-2
1.735E-1
1.000E0
 1 186
42 hsa-miR-425-5p:TargetScan hsa-miR-425-5p TargetScan 1.666E-2 3.450E-2
1.757E-1
1.000E0
 1 202
43 hsa-miR-146a-5p:Functional MTI Functional MTI miRTarbase 1.666E-2 3.450E-2
1.757E-1
1.000E0
 1 202
44 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 1.764E-2 3.450E-2
1.757E-1
1.000E0
 1 214
45 hsa-miR-193b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.773E-2 3.450E-2
1.757E-1
1.000E0
 1 215
46 hsa-miR-1226-3p:Functional MTI Functional MTI miRTarbase 1.871E-2 3.450E-2
1.757E-1
1.000E0
 1 227
47 hsa-miR-4533:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.895E-2 3.450E-2
1.757E-1
1.000E0
 1 230
48 hsa-miR-4725-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.912E-2 3.450E-2
1.757E-1
1.000E0
 1 232
49 hsa-miR-6780b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.912E-2 3.450E-2
1.757E-1
1.000E0
 1 232
50 hsa-miR-4271:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.944E-2 3.450E-2
1.757E-1
1.000E0
 1 236
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1965 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000043297 nitroindole Stitch 4.028E-11 7.915E-8 6.460E-7 7.915E-8 3 4
2 CID006450978 Dasm Stitch 1.208E-9 1.187E-6 9.684E-6 2.373E-6 3 10
3 CID000195871 Cbz-leu-leu-glu-2nnp Stitch 1.725E-7 1.025E-4 8.369E-4 3.390E-4 2 3
4 CID000657023 T1 p Stitch 2.087E-7 1.025E-4 8.369E-4 4.102E-4 3 51
5 CID000020591 2-amino-3-hydroxyacetophenone Stitch 3.450E-7 1.180E-4 9.632E-4 6.778E-4 2 4
6 CID000006763 9,10-phenanthrenequinone Stitch 3.604E-7 1.180E-4 9.632E-4 7.082E-4 3 61
7 CID000123808 bis-ANS Stitch 8.527E-7 2.118E-4 1.728E-3 1.676E-3 3 81
8 CID000022463 2,2'-dihydroxy-6,6'-dinaphthyldisulfide Stitch 8.622E-7 2.118E-4 1.728E-3 1.694E-3 2 6
9 ctd:C011994 pirimicarb CTD 1.207E-6 2.635E-4 2.150E-3 2.372E-3 2 7
10 CID000127761 AC1L2SL2 Stitch 1.609E-6 3.162E-4 2.580E-3 3.162E-3 2 8
11 CID011819039 imidazolon Stitch 2.069E-6 3.695E-4 3.015E-3 4.065E-3 2 9
12 CID003386230 AC1MPJID Stitch 2.591E-6 4.242E-4 3.462E-3 5.090E-3 3 117
13 CID000016017 aminoguanidine hydrochloride Stitch 4.480E-6 5.868E-4 4.789E-3 8.803E-3 2 13
14 ctd:C035359 monorden CTD 4.480E-6 5.868E-4 4.789E-3 8.803E-3 2 13
15 CID000095686 NSC29727 Stitch 4.480E-6 5.868E-4 4.789E-3 8.803E-3 2 13
16 CID000123554 CH3SOH Stitch 6.029E-6 7.132E-4 5.820E-3 1.185E-2 2 15
17 CID000000880 methylglyoxal Stitch 6.276E-6 7.132E-4 5.820E-3 1.233E-2 3 157
18 CID000121834 1,5-AEDANS Stitch 6.889E-6 7.132E-4 5.820E-3 1.354E-2 2 16
19 CID000007898 2-cyanoacetamide Stitch 6.896E-6 7.132E-4 5.820E-3 1.355E-2 3 162
20 CID000004897 Prednisolut Stitch 7.807E-6 7.670E-4 6.260E-3 1.534E-2 2 17
21 CID000004510 nitroglycerin Stitch 1.417E-5 1.326E-3 1.082E-2 2.785E-2 3 206
22 CID011378442 potassium cyanate Stitch 1.583E-5 1.414E-3 1.154E-2 3.111E-2 2 24
23 CID000123850 NBD-PE Stitch 1.721E-5 1.470E-3 1.200E-2 3.381E-2 2 25
24 CID000021157 buthionine sulfoximine Stitch 1.946E-5 1.582E-3 1.291E-2 3.823E-2 3 229
25 CID000516871 NaSCN Stitch 2.013E-5 1.582E-3 1.291E-2 3.955E-2 2 27
26 CID000122214 IANBD Stitch 2.327E-5 1.759E-3 1.435E-2 4.573E-2 2 29
27 CID000001127 tetrahydrothiophene Stitch 3.608E-5 2.584E-3 2.109E-2
7.091E-2
 2 36
28 CID000123933 DTSSP Stitch 3.814E-5 2.584E-3 2.109E-2
7.495E-2
 2 37
29 CID000119532 MIANS Stitch 3.814E-5 2.584E-3 2.109E-2
7.495E-2
 2 37
30 CID000094176 erythrose Stitch 4.466E-5 2.925E-3 2.387E-2
8.775E-2
 2 40
31 CID000000910 formylkynurenine Stitch 4.694E-5 2.975E-3 2.428E-2
9.224E-2
 2 41
32 CID000073046 mm o Stitch 7.877E-5 4.691E-3 3.828E-2
1.548E-1
 2 53
33 ctd:C016299 chelerythrine CTD 7.877E-5 4.691E-3 3.828E-2
1.548E-1
 2 53
34 ctd:C044101 endotoxin, Escherichia coli CTD 8.487E-5 4.765E-3 3.888E-2
1.668E-1
 2 55
35 CID000000540 cyanate Stitch 8.487E-5 4.765E-3 3.888E-2
1.668E-1
 2 55
36 ctd:D019820 Xanthine CTD 9.119E-5 4.883E-3 3.985E-2
1.792E-1
 2 57
37 ctd:C093642 SB 203580 CTD 9.365E-5 4.883E-3 3.985E-2
1.840E-1
 3 388
38 CID000000089 hydroxykynurenine Stitch 9.444E-5 4.883E-3 3.985E-2
1.856E-1
 2 58
39 ctd:C031721 naphthalene CTD 1.111E-4 5.598E-3 4.568E-2
2.183E-1
 3 411
40 CID000119593 pentosidine Stitch 1.151E-4 5.654E-3 4.614E-2
2.262E-1
 2 64
41 CID000019001 dithiotreitol Stitch 1.270E-4 6.082E-3 4.963E-2
2.496E-1
 3 430
42 CID000034750 dimethyl suberimidate Stitch 1.300E-4 6.082E-3 4.963E-2
2.554E-1
 2 68
43 ctd:C005435 phenylmethylpyrazolone CTD 1.339E-4 6.117E-3 4.992E-2
2.630E-1
 2 69
44 CID000445522 H-Mn Stitch 1.418E-4 6.190E-3
5.051E-2
2.785E-1
 2 71
45 ctd:D016566 Organoselenium Compounds CTD 1.418E-4 6.190E-3
5.051E-2
2.785E-1
 2 71
46 CID000009369 L-Carnosine Stitch 1.499E-4 6.373E-3
5.200E-2
2.945E-1
 2 73
47 CID000001369 8-anilino-1-naphthalenesulfonate Stitch 1.625E-4 6.373E-3
5.200E-2
3.193E-1
 2 76
48 CID000000847 L-methionine sulfoxide Stitch 1.668E-4 6.373E-3
5.200E-2
3.277E-1
 2 77
49 CID000107904 bityrosine Stitch 1.668E-4 6.373E-3
5.200E-2
3.277E-1
 2 77
50 ctd:C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine CTD 1.712E-4 6.373E-3
5.200E-2
3.363E-1
 2 78
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 476 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3711384 Distal Hereditary Motor Neuropathy, Type II DisGeNET BeFree 6.853E-7 3.262E-4 2.200E-3 3.262E-4 2 4
2 C1847823 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F DisGeNET Curated 1.713E-6 4.076E-4 2.749E-3 8.152E-4 2 6
3 C0151744 Myocardial Ischemia DisGeNET Curated 6.464E-6 1.026E-3 6.917E-3 3.077E-3 4 421
4 C0026780 Mumps DisGeNET BeFree 3.414E-5 4.063E-3 2.740E-2 1.625E-2 2 25
5 C0340100 High altitude pulmonary edema DisGeNET Curated 5.639E-5 4.510E-3 3.041E-2 2.684E-2 2 32
6 C0917798 Cerebral Ischemia DisGeNET Curated 5.684E-5 4.510E-3 3.041E-2 2.706E-2 3 233
7 C0007785 Cerebral Infarction DisGeNET Curated 7.789E-5 4.751E-3 3.204E-2 3.708E-2 3 259
8 C0235025 Peripheral motor neuropathy DisGeNET Curated 7.984E-5 4.751E-3 3.204E-2 3.800E-2 2 38
9 C0085220 Cerebral Amyloid Angiopathy DisGeNET Curated 9.308E-5 4.923E-3 3.320E-2 4.431E-2 2 41
10 C3714636 Pneumonitis DisGeNET BeFree 1.316E-4 5.805E-3 3.914E-2
6.264E-2
 3 309
11 C0333463 Senile Plaques DisGeNET BeFree 1.341E-4 5.805E-3 3.914E-2
6.385E-2
 3 311
12 C0035220 Respiratory Distress Syndrome, Newborn DisGeNET Curated 1.807E-4 7.168E-3 4.834E-2
8.601E-2
 2 57
13 C0270921 Axonal neuropathy DisGeNET Curated 2.139E-4 7.833E-3
5.282E-2
1.018E-1
 2 62
14 C2609414 Acute kidney injury DisGeNET Curated 2.887E-4 8.392E-3
5.660E-2
1.374E-1
 2 72
15 cv:C1858679 Cataract, autosomal dominant Clinical Variations 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
16 OMIN:158590 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIA; HMN2A OMIM 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
17 cv:C1834692 Distal hereditary motor neuronopathy type 2A Clinical Variations 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
18 OMIN:608673 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2L; CMT2L OMIM 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
19 cv:C1837552 Charcot-Marie-Tooth disease, type 2L Clinical Variations 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
20 C1834692 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIA DisGeNET Curated 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
21 C0282507 Heat Stress Disorders DisGeNET Curated 3.703E-4 8.392E-3
5.660E-2
1.762E-1
 1 1
22 C0035126 Reperfusion Injury DisGeNET Curated 4.023E-4 8.705E-3
5.870E-2
1.915E-1
 2 85
23 C1719672 Severe Sepsis DisGeNET BeFree 4.410E-4 9.127E-3
6.155E-2
2.099E-1
 2 89
24 C0032460 Polycystic Ovary Syndrome DisGeNET Curated 4.832E-4 9.274E-3
6.254E-2
2.300E-1
 3 480
25 C0740391 Middle Cerebral Artery Occlusion DisGeNET BeFree 6.368E-4 9.274E-3
6.254E-2
3.031E-1
 2 107
26 C0520679 Sleep Apnea, Obstructive DisGeNET Curated 6.728E-4 9.274E-3
6.254E-2
3.203E-1
 2 110
27 C2713497 Saccular Aneurysm DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
28 C0340557 Atherosclerotic renal artery stenosis DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
29 C2985307 Maternal Hypotension DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
30 C0262385 Autonomic nervous system imbalance DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
31 C0264656 Cardiovascular renal disease DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
32 C4024943 Decreased amplitude of sensory action potentials DisGeNET Curated 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
33 C4025696 Paresis of extensor muscles of the big toe DisGeNET Curated 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
34 cv:C0032914 Preeclampsia/eclampsia 1 Clinical Variations 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
35 C0852036 Pregnancy associated hypertension DisGeNET Curated 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
36 C0349453 Mass of thyroid gland DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
37 C0340569 Internal Carotid Artery Stenosis DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
38 C2903074 Vasculogenic erectile dysfunction DisGeNET BeFree 7.404E-4 9.274E-3
6.254E-2
3.524E-1
 1 2
39 C0949664 Tauopathies DisGeNET Curated 8.815E-4 1.076E-2
7.255E-2
4.196E-1
 2 126
40 C0340520 Athlete's heart DisGeNET BeFree 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
41 C1837552 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2L (disorder) DisGeNET Curated 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
42 C0033103 Pretibial myxedema DisGeNET BeFree 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
43 C0000832 Abruptio Placentae DisGeNET Curated 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
44 C2931193 Prinzmetal's variant angina DisGeNET BeFree 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
45 C0341318 Enterocutaneous Fistula DisGeNET BeFree 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
46 C0849925 Ventricular failure DisGeNET BeFree 1.110E-3 1.132E-2
7.633E-2
5.286E-1
 1 3
47 C0339573 Glaucoma, Primary Open Angle DisGeNET Curated 1.118E-3 1.132E-2
7.633E-2
5.320E-1
 2 142
48 C0007959 Charcot-Marie-Tooth Disease DisGeNET Curated 1.213E-3 1.203E-2
8.113E-2
5.775E-1
 2 148
49 C3888087 Charcot-Marie-Tooth disease, Type 2I DisGeNET Curated 1.480E-3 1.281E-2
8.640E-2
7.046E-1
 1 4
50 OMIN:604219 CATARACT, AUTOSOMAL DOMINANT OMIM 1.480E-3 1.281E-2
8.640E-2
7.046E-1
 1 4
Show 45 more annotations