Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc31_32, positive side

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Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 32 input genes in category / 115 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005267 potassium channel activity 1.460E-72 1.679E-70 8.941E-70 1.679E-70 32 122
2 GO:0015079 potassium ion transmembrane transporter activity 1.014E-69 5.833E-68 3.107E-67 1.167E-67 32 146
3 GO:0005261 cation channel activity 1.430E-58 5.481E-57 2.919E-56 1.644E-56 32 306
4 GO:0022836 gated channel activity 2.012E-57 5.785E-56 3.081E-55 2.314E-55 32 331
5 GO:0015077 monovalent inorganic cation transmembrane transporter activity 1.316E-55 3.028E-54 1.613E-53 1.514E-53 32 375
6 GO:0005216 ion channel activity 7.875E-54 1.509E-52 8.039E-52 9.056E-52 32 424
7 GO:0046873 metal ion transmembrane transporter activity 9.207E-54 1.513E-52 8.057E-52 1.059E-51 32 426
8 GO:0022838 substrate-specific channel activity 2.316E-53 3.329E-52 1.773E-51 2.664E-51 32 438
9 GO:0015267 channel activity 2.398E-52 2.959E-51 1.576E-50 2.758E-50 32 470
10 GO:0022803 passive transmembrane transporter activity 2.573E-52 2.959E-51 1.576E-50 2.959E-50 32 471
11 GO:0005249 voltage-gated potassium channel activity 1.210E-50 1.265E-49 6.741E-49 1.392E-48 24 91
12 GO:0005244 voltage-gated ion channel activity 7.327E-47 6.481E-46 3.452E-45 8.426E-45 26 198
13 GO:0022832 voltage-gated channel activity 7.327E-47 6.481E-46 3.452E-45 8.426E-45 26 198
14 GO:0005251 delayed rectifier potassium channel activity 5.299E-46 4.353E-45 2.319E-44 6.094E-44 19 37
15 GO:0022843 voltage-gated cation channel activity 1.529E-45 1.172E-44 6.245E-44 1.759E-43 24 141
16 GO:0015459 potassium channel regulator activity 4.092E-24 2.941E-23 1.566E-22 4.705E-22 12 48
17 GO:0015271 outward rectifier potassium channel activity 1.423E-20 9.627E-20 5.128E-19 1.637E-18 8 12
18 GO:0016247 channel regulator activity 3.575E-18 2.284E-17 1.217E-16 4.111E-16 12 139
19 GO:0044325 ion channel binding 1.066E-16 6.454E-16 3.438E-15 1.226E-14 11 127
20 GO:0015269 calcium-activated potassium channel activity 6.770E-16 3.893E-15 2.074E-14 7.786E-14 7 18
21 GO:0005227 calcium activated cation channel activity 4.271E-14 2.339E-13 1.246E-12 4.911E-12 7 30
22 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2.238E-13 1.170E-12 6.232E-12 2.574E-11 5 7
23 GO:0022839 ion gated channel activity 9.353E-13 4.677E-12 2.491E-11 1.076E-10 7 45
24 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 7.119E-12 3.411E-11 1.817E-10 8.187E-10 4 4
25 GO:0005250 A-type (transient outward) potassium channel activity 1.830E-8 8.418E-8 4.484E-7 2.105E-6 3 4
26 GO:0005516 calmodulin binding 7.484E-7 3.310E-6 1.763E-5 8.607E-5 6 190
27 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization 2.849E-6 1.213E-5 6.463E-5 3.276E-4 2 2
28 GO:0005242 inward rectifier potassium channel activity 9.046E-6 3.715E-5 1.979E-4 1.040E-3 3 24
29 GO:0016286 small conductance calcium-activated potassium channel activity 1.706E-5 6.764E-5 3.603E-4 1.961E-3 2 4
30 GO:0000155 phosphorelay sensor kinase activity 4.255E-5 1.631E-4 8.688E-4 4.893E-3 2 6
31 GO:0004673 protein histidine kinase activity 5.951E-5 2.207E-4 1.176E-3 6.843E-3 2 7
32 GO:0097110 scaffold protein binding 1.131E-4 3.887E-4 2.071E-3 1.301E-2 3 55
33 GO:0022834 ligand-gated channel activity 1.149E-4 3.887E-4 2.071E-3 1.322E-2 4 148
34 GO:0015276 ligand-gated ion channel activity 1.149E-4 3.887E-4 2.071E-3 1.322E-2 4 148
35 GO:0016775 phosphotransferase activity, nitrogenous group as acceptor 2.196E-4 7.216E-4 3.843E-3 2.525E-2 2 13
36 GO:0051393 alpha-actinin binding 8.338E-4 2.664E-3 1.419E-2
9.589E-2
 2 25
37 GO:0047485 protein N-terminus binding 1.043E-3 3.243E-3 1.727E-2
1.200E-1
 3 117
38 GO:0022894 Intermediate conductance calcium-activated potassium channel activity 1.715E-3 4.854E-3 2.586E-2
1.972E-1
 1 1
39 GO:0086087 voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization 1.715E-3 4.854E-3 2.586E-2
1.972E-1
 1 1
40 GO:0086090 voltage-gated potassium channel activity involved in SA node cell action potential repolarization 1.715E-3 4.854E-3 2.586E-2
1.972E-1
 1 1
41 GO:0042805 actinin binding 1.731E-3 4.854E-3 2.586E-2
1.990E-1
 2 36
42 GO:0008200 ion channel inhibitor activity 2.029E-3 5.556E-3 2.959E-2
2.333E-1
 2 39
43 GO:0016248 channel inhibitor activity 2.241E-3 5.992E-3 3.192E-2
2.577E-1
 2 41
44 GO:0060072 large conductance calcium-activated potassium channel activity 3.427E-3 8.956E-3 4.771E-2
3.941E-1
 1 2
45 GO:0046923 ER retention sequence binding 8.546E-3 2.136E-2
1.138E-1
9.827E-1
 1 5
46 GO:0031433 telethonin binding 8.546E-3 2.136E-2
1.138E-1
9.827E-1
 1 5
47 GO:0055131 C3HC4-type RING finger domain binding 1.025E-2 2.507E-2
1.335E-1
1.000E0
 1 6
48 GO:0019870 potassium channel inhibitor activity 1.364E-2 3.268E-2
1.741E-1
1.000E0
 1 8
Show 43 more annotations

2: GO: Biological Process [Display Chart] 32 input genes in category / 517 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071805 potassium ion transmembrane transport 2.238E-66 5.785E-64 3.949E-63 1.157E-63 32 181
2 GO:0071804 cellular potassium ion transport 2.238E-66 5.785E-64 3.949E-63 1.157E-63 32 181
3 GO:0006813 potassium ion transport 2.713E-63 4.676E-61 3.192E-60 1.403E-60 32 222
4 GO:0034765 regulation of ion transmembrane transport 1.048E-41 1.354E-39 9.246E-39 5.418E-39 28 455
5 GO:0034762 regulation of transmembrane transport 3.197E-41 3.306E-39 2.257E-38 1.653E-38 28 473
6 GO:0042391 regulation of membrane potential 3.063E-26 2.639E-24 1.801E-23 1.583E-23 20 391
7 GO:0035637 multicellular organismal signaling 6.346E-26 4.687E-24 3.199E-23 3.281E-23 17 197
8 GO:0071435 potassium ion export 1.447E-20 9.348E-19 6.381E-18 7.479E-18 8 12
9 GO:0043266 regulation of potassium ion transport 1.819E-20 1.045E-18 7.134E-18 9.405E-18 12 91
10 GO:0001508 action potential 3.512E-20 1.816E-18 1.239E-17 1.816E-17 13 138
11 GO:1901379 regulation of potassium ion transmembrane transport 5.609E-20 2.636E-18 1.799E-17 2.900E-17 11 66
12 GO:1903522 regulation of blood circulation 9.570E-17 4.123E-15 2.814E-14 4.947E-14 14 334
13 GO:0086009 membrane repolarization 1.096E-15 4.360E-14 2.976E-13 5.668E-13 8 37
14 GO:0061337 cardiac conduction 1.184E-14 4.372E-13 2.985E-12 6.121E-12 10 131
15 GO:1904062 regulation of cation transmembrane transport 1.201E-13 4.138E-12 2.825E-11 6.207E-11 11 238
16 GO:0019228 neuronal action potential 4.722E-13 1.526E-11 1.042E-10 2.441E-10 7 41
17 GO:0010959 regulation of metal ion transport 5.681E-13 1.728E-11 1.179E-10 2.937E-10 12 374
18 GO:0019226 transmission of nerve impulse 7.835E-13 2.250E-11 1.536E-10 4.051E-10 8 80
19 GO:0051260 protein homooligomerization 1.508E-12 4.104E-11 2.802E-10 7.798E-10 11 300
20 GO:0008016 regulation of heart contraction 5.724E-12 1.480E-10 1.010E-9 2.959E-9 10 242
21 GO:0086013 membrane repolarization during cardiac muscle cell action potential 8.477E-12 2.087E-10 1.425E-9 4.382E-9 5 12
22 GO:0060306 regulation of membrane repolarization 9.031E-12 2.122E-10 1.449E-9 4.669E-9 6 30
23 GO:0060047 heart contraction 2.103E-11 4.605E-10 3.143E-9 1.087E-8 10 276
24 GO:0005513 detection of calcium ion 2.138E-11 4.605E-10 3.143E-9 1.105E-8 5 14
25 GO:0003015 heart process 2.339E-11 4.838E-10 3.302E-9 1.209E-8 10 279
26 GO:0043267 negative regulation of potassium ion transport 2.454E-11 4.880E-10 3.331E-9 1.269E-8 6 35
27 GO:0086011 membrane repolarization during action potential 3.202E-11 6.132E-10 4.186E-9 1.656E-8 5 15
28 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential 1.074E-10 1.983E-9 1.354E-8 5.553E-8 4 6
29 GO:0099623 regulation of cardiac muscle cell membrane repolarization 2.154E-10 3.841E-9 2.622E-8 1.114E-7 5 21
30 GO:0086001 cardiac muscle cell action potential 3.016E-10 5.197E-9 3.548E-8 1.559E-7 6 52
31 GO:1901380 negative regulation of potassium ion transmembrane transport 3.554E-10 5.927E-9 4.046E-8 1.837E-7 5 23
32 GO:0099622 cardiac muscle cell membrane repolarization 5.598E-10 9.044E-9 6.173E-8 2.894E-7 5 25
33 GO:1903817 negative regulation of voltage-gated potassium channel activity 1.496E-9 2.275E-8 1.553E-7 7.737E-7 4 10
34 GO:1902260 negative regulation of delayed rectifier potassium channel activity 1.496E-9 2.275E-8 1.553E-7 7.737E-7 4 10
35 GO:0051592 response to calcium ion 1.604E-9 2.370E-8 1.618E-7 8.295E-7 7 126
36 GO:0086091 regulation of heart rate by cardiac conduction 1.777E-9 2.552E-8 1.742E-7 9.188E-7 5 31
37 GO:0086002 cardiac muscle cell action potential involved in contraction 3.919E-9 5.477E-8 3.738E-7 2.026E-6 5 36
38 GO:0099625 ventricular cardiac muscle cell membrane repolarization 2.160E-8 2.791E-7 1.905E-6 1.117E-5 4 18
39 GO:1901017 negative regulation of potassium ion transmembrane transporter activity 2.160E-8 2.791E-7 1.905E-6 1.117E-5 4 18
40 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 2.160E-8 2.791E-7 1.905E-6 1.117E-5 4 18
41 GO:0086003 cardiac muscle cell contraction 2.650E-8 3.342E-7 2.281E-6 1.370E-5 5 52
42 GO:1902259 regulation of delayed rectifier potassium channel activity 2.732E-8 3.363E-7 2.296E-6 1.413E-5 4 19
43 GO:1904064 positive regulation of cation transmembrane transport 4.071E-8 4.894E-7 3.341E-6 2.105E-5 6 116
44 GO:0086005 ventricular cardiac muscle cell action potential 7.445E-8 8.748E-7 5.972E-6 3.849E-5 4 24
45 GO:1904063 negative regulation of cation transmembrane transport 9.671E-8 1.097E-6 7.486E-6 5.000E-5 5 67
46 GO:0006936 muscle contraction 9.758E-8 1.097E-6 7.486E-6 5.045E-5 8 348
47 GO:0010038 response to metal ion 1.377E-7 1.515E-6 1.034E-5 7.121E-5 8 364
48 GO:0043271 negative regulation of ion transport 1.540E-7 1.659E-6 1.132E-5 7.963E-5 6 145
49 GO:0034767 positive regulation of ion transmembrane transport 2.036E-7 2.149E-6 1.467E-5 1.053E-4 6 152
50 GO:1901381 positive regulation of potassium ion transmembrane transport 2.186E-7 2.261E-6 1.543E-5 1.130E-4 4 31
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 32 input genes in category / 86 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008076 voltage-gated potassium channel complex 1.656E-73 1.068E-71 5.381E-71 1.424E-71 31 92
2 GO:0034705 potassium channel complex 2.484E-73 1.068E-71 5.381E-71 2.137E-71 31 93
3 GO:0034703 cation channel complex 1.655E-63 4.744E-62 2.390E-61 1.423E-61 31 176
4 GO:0034702 ion channel complex 3.066E-56 6.592E-55 3.320E-54 2.637E-54 31 291
5 GO:1902495 transmembrane transporter complex 1.374E-54 2.363E-53 1.190E-52 1.181E-52 31 327
6 GO:1990351 transporter complex 2.480E-54 3.554E-53 1.790E-52 2.133E-52 31 333
7 GO:0098857 membrane microdomain 1.418E-10 1.525E-9 7.680E-9 1.220E-8 10 343
8 GO:0045121 membrane raft 1.418E-10 1.525E-9 7.680E-9 1.220E-8 10 343
9 GO:0033267 axon part 1.392E-9 1.330E-8 6.699E-8 1.197E-7 9 309
10 GO:0044304 main axon 2.329E-9 2.003E-8 1.009E-7 2.003E-7 6 74
11 GO:0032809 neuronal cell body membrane 1.508E-7 1.081E-6 5.445E-6 1.297E-5 4 29
12 GO:0044298 cell body membrane 1.508E-7 1.081E-6 5.445E-6 1.297E-5 4 29
13 GO:0044224 juxtaparanode region of axon 5.117E-7 3.385E-6 1.705E-5 4.400E-5 3 10
14 GO:0043679 axon terminus 5.844E-7 3.590E-6 1.808E-5 5.026E-5 6 186
15 GO:0044306 neuron projection terminus 8.679E-7 4.976E-6 2.507E-5 7.464E-5 6 199
16 GO:0043204 perikaryon 3.662E-6 1.968E-5 9.915E-5 3.149E-4 5 142
17 GO:0042383 sarcolemma 5.110E-6 2.585E-5 1.302E-4 4.394E-4 5 152
18 GO:0042734 presynaptic membrane 7.710E-6 3.683E-5 1.856E-4 6.630E-4 4 76
19 GO:0097060 synaptic membrane 8.936E-6 4.045E-5 2.037E-4 7.685E-4 6 298
20 GO:0016324 apical plasma membrane 1.736E-5 7.466E-5 3.761E-4 1.493E-3 6 335
21 GO:0005901 caveola 1.950E-5 7.985E-5 4.022E-4 1.677E-3 4 96
22 GO:0044853 plasma membrane raft 2.776E-5 1.085E-4 5.467E-4 2.388E-3 4 105
23 GO:0045177 apical part of cell 6.834E-5 2.555E-4 1.287E-3 5.877E-3 6 428
24 GO:0043194 axon initial segment 2.105E-4 7.544E-4 3.800E-3 1.811E-2 2 13
25 GO:0097038 perinuclear endoplasmic reticulum 2.828E-4 9.729E-4 4.901E-3 2.432E-2 2 15
26 GO:0033268 node of Ranvier 3.229E-4 1.068E-3 5.380E-3 2.777E-2 2 16
27 GO:0098794 postsynapse 8.448E-4 2.691E-3 1.355E-2
7.265E-2
 5 449
28 GO:0030018 Z disc 1.031E-3 3.167E-3 1.595E-2
8.868E-2
 3 119
29 GO:0031674 I band 1.483E-3 4.397E-3 2.215E-2
1.275E-1
 3 135
30 GO:1990031 pinceau fiber 1.679E-3 4.813E-3 2.424E-2
1.444E-1
 1 1
31 GO:0031256 leading edge membrane 2.004E-3 5.560E-3 2.801E-2
1.724E-1
 3 150
32 GO:0098793 presynapse 2.437E-3 6.549E-3 3.299E-2
2.096E-1
 4 341
33 GO:0032589 neuron projection membrane 3.057E-3 7.966E-3 4.013E-2
2.629E-1
 2 49
34 GO:0030017 sarcomere 4.387E-3 1.110E-2
5.589E-2
3.773E-1
 3 198
35 GO:0030315 T-tubule 4.548E-3 1.118E-2
5.630E-2
3.911E-1
 2 60
36 GO:0046691 intracellular canaliculus 5.028E-3 1.201E-2
6.051E-2
4.324E-1
 1 3
37 GO:0044449 contractile fiber part 5.516E-3 1.282E-2
6.458E-2
4.744E-1
 3 215
38 GO:0030016 myofibril 5.878E-3 1.330E-2
6.701E-2
5.055E-1
 3 220
39 GO:0045211 postsynaptic membrane 6.255E-3 1.379E-2
6.948E-2
5.379E-1
 3 225
40 GO:0043292 contractile fiber 6.968E-3 1.498E-2
7.546E-2
5.992E-1
 3 234
41 GO:0016323 basolateral plasma membrane 7.815E-3 1.639E-2
8.258E-2
6.721E-1
 3 244
42 GO:0048787 presynaptic active zone membrane 8.367E-3 1.713E-2
8.630E-2
7.195E-1
 1 5
43 GO:0031253 cell projection membrane 1.788E-2 3.577E-2
1.802E-1
1.000E0
 3 332
44 GO:0042589 zymogen granule membrane 2.326E-2 4.546E-2
2.290E-1
1.000E0
 1 14
45 GO:0033270 paranode region of axon 2.490E-2 4.758E-2
2.397E-1
1.000E0
 1 15
46 GO:0043197 dendritic spine 2.647E-2 4.860E-2
2.448E-1
1.000E0
 2 151
47 GO:0031252 cell leading edge 2.701E-2 4.860E-2
2.448E-1
1.000E0
 3 389
48 GO:0044309 neuron spine 2.713E-2 4.860E-2
2.448E-1
1.000E0
 2 153
Show 43 more annotations

4: Human Phenotype [Display Chart] 20 input genes in category / 708 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001657 Prolonged QT interval 7.352E-8 3.228E-5 2.305E-4 5.205E-5 6 56
2 HP:0031547 Abnormal QT interval 9.118E-8 3.228E-5 2.305E-4 6.456E-5 6 58
3 HP:0006682 Ventricular extrasystoles 1.777E-7 4.195E-5 2.995E-4 1.258E-4 5 33
4 HP:0005110 Atrial fibrillation 3.120E-7 4.529E-5 3.234E-4 2.209E-4 6 71
5 HP:0001692 Atrial arrhythmia 4.005E-7 4.529E-5 3.234E-4 2.835E-4 6 74
6 HP:0003115 Abnormal EKG 4.702E-7 4.529E-5 3.234E-4 3.329E-4 6 76
7 HP:0500014 Abnormal test result 6.396E-7 4.529E-5 3.234E-4 4.529E-4 6 80
8 HP:0500015 Abnormal cardiac test 6.396E-7 4.529E-5 3.234E-4 4.529E-4 6 80
9 HP:0004755 Supraventricular tachycardia 6.396E-7 4.529E-5 3.234E-4 4.529E-4 6 80
10 HP:0003114 Abnormal cardiological findings 6.396E-7 4.529E-5 3.234E-4 4.529E-4 6 80
11 HP:0005115 Supraventricular arrhythmia 7.415E-7 4.773E-5 3.408E-4 5.250E-4 6 82
12 HP:0001663 Ventricular fibrillation 1.232E-6 7.268E-5 5.190E-4 8.722E-4 5 48
13 HP:0001962 Palpitations 3.210E-6 1.748E-4 1.248E-3 2.272E-3 5 58
14 HP:0006696 Polymorphic and polytopic ventricular extrasystoles 5.424E-6 2.743E-4 1.959E-3 3.840E-3 3 9
15 HP:0001649 Tachycardia 1.328E-5 6.270E-4 4.477E-3 9.406E-3 6 134
16 HP:0011198 EEG with generalized epileptiform discharges 2.532E-5 1.120E-3 8.000E-3 1.793E-2 5 88
17 HP:0011182 Interictal epileptiform activity 3.491E-5 1.454E-3 1.038E-2 2.472E-2 5 94
18 HP:0001279 Syncope 3.867E-5 1.521E-3 1.086E-2 2.738E-2 5 96
19 HP:0001645 Sudden cardiac death 6.828E-5 2.544E-3 1.817E-2 4.834E-2 5 108
20 HP:0001664 Torsade de pointes 9.599E-5 3.398E-3 2.426E-2
6.796E-2
 3 22
21 HP:0001695 Cardiac arrest 1.480E-4 4.852E-3 3.465E-2
1.048E-1
 5 127
22 HP:0025373 Interictal EEG abnormality 1.702E-4 4.852E-3 3.465E-2
1.205E-1
 2 5
23 HP:0040168 Focal seizures, afebril 1.702E-4 4.852E-3 3.465E-2
1.205E-1
 2 5
24 HP:0002372 Normal interictal EEG 1.702E-4 4.852E-3 3.465E-2
1.205E-1
 2 5
25 HP:0004308 Ventricular arrhythmia 1.713E-4 4.852E-3 3.465E-2
1.213E-1
 5 131
26 HP:0011702 Abnormal electrophysiology of sinoatrial node origin 3.610E-4 9.300E-3
6.641E-2
2.556E-1
 3 34
27 HP:0005142 Atrioventricular nodal disease 3.678E-4 9.300E-3
6.641E-2
2.604E-1
 4 84
28 HP:0005150 Abnormal atrioventricular conduction 3.678E-4 9.300E-3
6.641E-2
2.604E-1
 4 84
29 HP:0012232 Shortened QT interval 4.730E-4 1.155E-2
8.246E-2
3.349E-1
 2 8
30 HP:0001699 Sudden death 6.311E-4 1.489E-2
1.063E-1
4.468E-1
 3 41
31 HP:0012722 Heart block 7.154E-4 1.623E-2
1.159E-1
5.065E-1
 4 100
32 HP:0031546 Cardiac conduction abnormality 7.429E-4 1.623E-2
1.159E-1
5.260E-1
 4 101
33 HP:0012534 Dysesthesia 7.564E-4 1.623E-2
1.159E-1
5.355E-1
 2 10
34 HP:0002266 Focal clonic seizures 9.221E-4 1.920E-2
1.371E-1
6.528E-1
 2 11
35 HP:0011097 Epileptic spasms 1.005E-3 2.032E-2
1.451E-1
7.113E-1
 3 48
36 HP:0001665 Abnormality of cardiac conduction 1.055E-3 2.074E-2
1.481E-1
7.467E-1
 6 295
37 HP:0004756 Ventricular tachycardia 1.418E-3 2.641E-2
1.886E-1
1.000E0
 3 54
38 HP:0002121 Absence seizure 1.418E-3 2.641E-2
1.886E-1
1.000E0
 3 54
39 HP:0005141 Episodes of ventricular tachycardia 1.986E-3 3.516E-2
2.510E-1
1.000E0
 2 16
40 HP:0005184 Prolonged QTc interval 1.986E-3 3.516E-2
2.510E-1
1.000E0
 2 16
41 HP:0007334 Generalized tonic-clonic seizures with focal onset 2.520E-3 4.267E-2
3.047E-1
1.000E0
 2 18
42 HP:0200134 Epileptic encephalopathy 2.531E-3 4.267E-2
3.047E-1
1.000E0
 3 66
43 HP:0002521 Hypsarrhythmia 2.757E-3 4.420E-2
3.156E-1
1.000E0
 3 68
44 HP:0011150 Myoclonic absence 2.809E-3 4.420E-2
3.156E-1
1.000E0
 2 19
45 HP:0011148 Absence seizures with special features 2.809E-3 4.420E-2
3.156E-1
1.000E0
 2 19
46 HP:0011146 Dialeptic seizures 3.119E-3 4.801E-2
3.428E-1
1.000E0
 3 71
Show 41 more annotations

5: Mouse Phenotype [Display Chart] 27 input genes in category / 458 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003484 abnormal channel response 4.520E-10 1.356E-7 9.089E-7 2.070E-7 6 38
2 MP:0002272 abnormal nervous system electrophysiology 5.919E-10 1.356E-7 9.089E-7 2.711E-7 11 359
3 MP:0005402 abnormal action potential 4.556E-8 6.956E-6 4.664E-5 2.087E-5 7 138
4 MP:0003412 abnormal afterhyperpolarization 1.094E-7 1.253E-5 8.400E-5 5.011E-5 4 18
5 MP:0008006 increased stomach pH 4.444E-6 4.071E-4 2.729E-3 2.035E-3 3 13
6 MP:0008004 abnormal stomach pH 8.656E-6 6.607E-4 4.430E-3 3.964E-3 3 16
7 MP:0001994 increased blinking frequency 1.961E-5 1.283E-3 8.604E-3 8.982E-3 2 3
8 MP:0003883 enlarged stomach 2.356E-5 1.349E-3 9.043E-3 1.079E-2 3 22
9 MP:0002578 impaired ability to fire action potentials 3.085E-5 1.570E-3 1.053E-2 1.413E-2 3 24
10 MP:0002064 seizures 4.705E-5 2.155E-3 1.445E-2 2.155E-2 7 390
11 MP:0003285 gastric hypertrophy 6.516E-5 2.296E-3 1.539E-2 2.984E-2 2 5
12 MP:0008003 achlorhydria 6.516E-5 2.296E-3 1.539E-2 2.984E-2 2 5
13 MP:0008001 hypochlorhydria 6.516E-5 2.296E-3 1.539E-2 2.984E-2 2 5
14 MP:0000501 abnormal digestive secretion 8.188E-5 2.679E-3 1.796E-2 3.750E-2 3 33
15 MP:0004737 absent distortion product otoacoustic emissions 9.788E-5 2.989E-3 2.004E-2 4.483E-2 3 35
16 MP:0004731 increased circulating gastrin level 1.816E-4 5.197E-3 3.485E-2
8.316E-2
 2 8
17 MP:0004730 abnormal circulating gastrin level 2.331E-4 6.279E-3 4.210E-2
1.067E-1
 2 9
18 MP:0001993 abnormal blinking 3.549E-4 8.556E-3
5.737E-2
1.626E-1
 2 11
19 MP:0010505 abnormal T wave 3.549E-4 8.556E-3
5.737E-2
1.626E-1
 2 11
20 MP:0002733 abnormal thermal nociception 7.132E-4 1.604E-2
1.075E-1
3.266E-1
 4 159
21 MP:0004736 abnormal distortion product otoacoustic emission 7.386E-4 1.604E-2
1.075E-1
3.383E-1
 3 69
22 MP:0006336 abnormal otoacoustic response 7.703E-4 1.604E-2
1.075E-1
3.528E-1
 3 70
23 MP:0001636 irregular heartbeat 9.059E-4 1.794E-2
1.203E-1
4.149E-1
 3 74
24 MP:0001963 abnormal hearing physiology 9.698E-4 1.794E-2
1.203E-1
4.442E-1
 6 458
25 MP:0004994 abnormal brain wave pattern 9.791E-4 1.794E-2
1.203E-1
4.484E-1
 3 76
26 MP:0001522 impaired swimming 1.056E-3 1.848E-2
1.239E-1
4.836E-1
 3 78
27 MP:0004140 abnormal gastric chief cell morphology 1.089E-3 1.848E-2
1.239E-1
4.990E-1
 2 19
28 MP:0003477 abnormal nerve fiber response 1.209E-3 1.977E-2
1.325E-1
5.535E-1
 2 20
29 MP:0000745 tremors 1.368E-3 2.161E-2
1.449E-1
6.266E-1
 5 326
30 MP:0009357 abnormal seizure response to inducing agent 1.524E-3 2.327E-2
1.560E-1
6.980E-1
 4 195
31 MP:0003137 abnormal impulse conducting system conduction 2.143E-3 3.160E-2
2.119E-1
9.815E-1
 4 214
32 MP:0004139 abnormal gastric parietal cell morphology 2.208E-3 3.160E-2
2.119E-1
1.000E0
 2 27
33 MP:0003478 abnormal nerve fiber response threshold 2.607E-3 3.228E-2
2.164E-1
1.000E0
 1 1
34 MP:0003483 decreased nerve fiber response threshold 2.607E-3 3.228E-2
2.164E-1
1.000E0
 1 1
35 MP:0006324 abnormal cochlear nerve fiber response 2.607E-3 3.228E-2
2.164E-1
1.000E0
 1 1
36 MP:0013468 chromodacryorrhea 2.607E-3 3.228E-2
2.164E-1
1.000E0
 1 1
37 MP:0009531 increased parotid gland size 2.607E-3 3.228E-2
2.164E-1
1.000E0
 1 1
38 MP:0001650 abnormal seizure response to electrical stimulation 2.723E-3 3.282E-2
2.200E-1
1.000E0
 2 30
39 MP:0002906 increased susceptibility to pharmacologically induced seizures 2.834E-3 3.308E-2
2.218E-1
1.000E0
 3 110
40 MP:0008739 abnormal spleen iron level 2.906E-3 3.308E-2
2.218E-1
1.000E0
 2 31
41 MP:0012349 increased susceptibility to induction of seizure by inducing agent 2.982E-3 3.308E-2
2.218E-1
1.000E0
 3 112
42 MP:0001664 abnormal digestion 3.058E-3 3.308E-2
2.218E-1
1.000E0
 3 113
43 MP:0006335 abnormal hearing electrophysiology 3.106E-3 3.308E-2
2.218E-1
1.000E0
 5 393
44 MP:0001970 abnormal pain threshold 3.813E-3 3.806E-2
2.552E-1
1.000E0
 4 251
45 MP:0003892 abnormal gastric gland morphology 3.906E-3 3.806E-2
2.552E-1
1.000E0
 2 36
46 MP:0006329 sensorineural hearing impairment 3.906E-3 3.806E-2
2.552E-1
1.000E0
 2 36
47 MP:0004740 sensorineural hearing loss 3.906E-3 3.806E-2
2.552E-1
1.000E0
 2 36
48 MP:0004432 abnormal cochlear hair cell physiology 4.344E-3 4.145E-2
2.779E-1
1.000E0
 2 38
49 MP:0010634 increased QRS amplitude 5.208E-3 4.632E-2
3.106E-1
1.000E0
 1 2
50 MP:0013569 gastric gland hyperplasia 5.208E-3 4.632E-2
3.106E-1
1.000E0
 1 2
Show 45 more annotations

6: Domain [Display Chart] 32 input genes in category / 104 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR028325 VG K chnl InterPro 6.323E-38 6.576E-36 3.437E-35 6.576E-36 16 33
2 IPR005821 Ion trans dom InterPro 1.408E-32 4.882E-31 2.551E-30 1.464E-30 18 114
3 PF00520 Ion trans Pfam 1.408E-32 4.882E-31 2.551E-30 1.464E-30 18 114
4 IPR003968 K chnl volt-dep Kv InterPro 3.649E-22 9.487E-21 4.958E-20 3.795E-20 10 27
5 IPR003972 K chnl volt-dep Kv1 InterPro 1.675E-19 3.484E-18 1.821E-17 1.742E-17 7 8
6 IPR003131 T1-type BTB InterPro 8.203E-19 1.219E-17 6.369E-17 8.531E-17 10 53
7 PF02214 BTB 2 Pfam 8.203E-19 1.219E-17 6.369E-17 8.531E-17 10 53
8 1.20.120.350 - Gene3D 1.809E-18 2.090E-17 1.092E-16 1.881E-16 10 57
9 IPR027359 Channel four-helix dom InterPro 1.809E-18 2.090E-17 1.092E-16 1.881E-16 10 57
10 IPR013821 K chnl volt-dep KCNQ C InterPro 1.047E-14 9.078E-14 4.745E-13 1.089E-12 5 5
11 IPR003937 K chnl volt-dep KCNQ InterPro 1.047E-14 9.078E-14 4.745E-13 1.089E-12 5 5
12 PF03520 KCNQ channel Pfam 1.047E-14 9.078E-14 4.745E-13 1.089E-12 5 5
13 SM00225 BTB SMART 2.800E-13 2.240E-12 1.171E-11 2.912E-11 10 180
14 IPR000210 BTB/POZ dom InterPro 3.689E-13 2.740E-12 1.432E-11 3.836E-11 10 185
15 IPR011333 SKP1/BTB/POZ InterPro 4.573E-13 3.171E-12 1.657E-11 4.756E-11 10 189
16 PF03185 CaKB Pfam 7.007E-12 4.287E-11 2.240E-10 7.288E-10 4 4
17 IPR003930 K chnl Ca-activ BK bsu InterPro 7.007E-12 4.287E-11 2.240E-10 7.288E-10 4 4
18 IPR000369 K chnl KCNE InterPro 1.049E-10 5.740E-10 3.000E-9 1.091E-8 4 6
19 PF02060 ISK Channel Pfam 1.049E-10 5.740E-10 3.000E-9 1.091E-8 4 6
20 IPR028846 Recoverin InterPro 1.280E-6 6.654E-6 3.478E-5 1.331E-4 3 13
21 IPR020969 Ankyrin-G BS InterPro 2.826E-6 1.278E-5 6.679E-5 2.939E-4 2 2
22 PF11956 KCNQC3-Ank-G bd Pfam 2.826E-6 1.278E-5 6.679E-5 2.939E-4 2 2
23 IPR003947 K chnl volt-dep KCNQ2 InterPro 2.826E-6 1.278E-5 6.679E-5 2.939E-4 2 2
24 IPR024587 K chnl volt-dep Kv4 C InterPro 8.470E-6 3.146E-5 1.644E-4 8.809E-4 2 3
25 PF11879 DUF3399 Pfam 8.470E-6 3.146E-5 1.644E-4 8.809E-4 2 3
26 IPR021645 Shal-type N InterPro 8.470E-6 3.146E-5 1.644E-4 8.809E-4 2 3
27 IPR003975 K chnl volt-dep Kv4 InterPro 8.470E-6 3.146E-5 1.644E-4 8.809E-4 2 3
28 PF11601 Shal-type Pfam 8.470E-6 3.146E-5 1.644E-4 8.809E-4 2 3
29 IPR015449 K chnl Ca-activ SK InterPro 1.692E-5 5.333E-5 2.787E-4 1.760E-3 2 4
30 IPR004178 CaM-bd dom InterPro 1.692E-5 5.333E-5 2.787E-4 1.760E-3 2 4
31 SM01053 CaMBD SMART 1.692E-5 5.333E-5 2.787E-4 1.760E-3 2 4
32 PF02888 CaMBD Pfam 1.692E-5 5.333E-5 2.787E-4 1.760E-3 2 4
33 PF03530 SK channel Pfam 1.692E-5 5.333E-5 2.787E-4 1.760E-3 2 4
34 PF13833 EF-hand 8 Pfam 2.613E-5 7.992E-5 4.177E-4 2.717E-3 3 34
35 PF13426 PAS 9 Pfam 1.261E-4 3.747E-4 1.958E-3 1.311E-2 2 10
36 IPR003938 K chnl volt-dep EAG/ELK/ERG InterPro 2.539E-4 7.336E-4 3.834E-3 2.641E-2 2 14
37 PF13499 EF-hand 7 Pfam 4.065E-4 1.143E-3 5.972E-3 4.228E-2 3 85
38 IPR013099 K chnl dom InterPro 5.816E-4 1.551E-3 8.106E-3
6.049E-2
 2 21
39 PF07885 Ion trans 2 Pfam 5.816E-4 1.551E-3 8.106E-3
6.049E-2
 2 21
40 IPR000700 PAS-assoc C InterPro 7.620E-4 1.981E-3 1.035E-2
7.925E-2
 2 24
41 IPR013767 PAS fold InterPro 8.274E-4 2.049E-3 1.071E-2
8.604E-2
 2 25
42 PF00989 PAS Pfam 8.274E-4 2.049E-3 1.071E-2
8.604E-2
 2 25
43 IPR001610 PAC InterPro 8.953E-4 2.069E-3 1.081E-2
9.312E-2
 2 26
44 SM00086 PAC SMART 8.953E-4 2.069E-3 1.081E-2
9.312E-2
 2 26
45 PS50113 PAC PROSITE 8.953E-4 2.069E-3 1.081E-2
9.312E-2
 2 26
46 PS00888 CNMP BINDING 1 PROSITE 1.358E-3 2.337E-3 1.222E-2
1.412E-1
 2 32
47 PS00889 CNMP BINDING 2 PROSITE 1.358E-3 2.337E-3 1.222E-2
1.412E-1
 2 32
48 SM00091 PAS SMART 1.358E-3 2.337E-3 1.222E-2
1.412E-1
 2 32
49 PS50112 PAS PROSITE 1.532E-3 2.337E-3 1.222E-2
1.594E-1
 2 34
50 SM00100 cNMP SMART 1.532E-3 2.337E-3 1.222E-2
1.594E-1
 2 34
Show 45 more annotations

7: Pathway [Display Chart] 32 input genes in category / 64 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268821 Potassium Channels BioSystems: REACTOME 5.200E-48 3.328E-46 1.579E-45 3.328E-46 25 100
2 1268830 Voltage gated Potassium channels BioSystems: REACTOME 5.924E-38 1.896E-36 8.993E-36 3.791E-36 18 44
3 1268763 Neuronal System BioSystems: REACTOME 2.154E-33 4.595E-32 2.180E-31 1.378E-31 25 351
4 1268822 Ca2+ activated K+ channels BioSystems: REACTOME 1.315E-17 2.104E-16 9.979E-16 8.414E-16 7 9
5 1339120 Phase 3 - rapid repolarisation BioSystems: REACTOME 4.894E-15 6.264E-14 2.972E-13 3.132E-13 6 8
6 1339115 Cardiac conduction BioSystems: REACTOME 3.019E-14 3.221E-13 1.528E-12 1.932E-12 11 142
7 1269868 Muscle contraction BioSystems: REACTOME 1.667E-12 1.353E-11 6.420E-11 1.067E-10 11 204
8 1339118 Phase 1 - inactivation of fast Na+ channels BioSystems: REACTOME 1.692E-12 1.353E-11 6.420E-11 1.083E-10 5 7
9 SMP00324 Procainamide (Antiarrhythmic) Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
10 SMP00332 Ibutilide Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
11 SMP00330 Tocainide Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
12 SMP00329 Mexiletine Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
13 SMP00326 Fosphenytoin (Antiarrhythmic) Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
14 SMP00325 Disopyramide Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
15 SMP00328 Lidocaine (Antiarrhythmic) Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
16 SMP00331 Flecainide Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
17 SMP00327 Phenytoin (Antiarrhythmic) Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
18 SMP00323 Quinidine Pathway SMPDB 3.857E-10 1.372E-9 6.506E-9 2.469E-8 6 37
19 1269344 cGMP effects BioSystems: REACTOME 6.766E-10 2.279E-9 1.081E-8 4.330E-8 5 18
20 777534 Insulin secretion BioSystems: KEGG 1.577E-9 5.045E-9 2.393E-8 1.009E-7 7 85
21 1269343 Nitric oxide stimulates guanylate cyclase BioSystems: REACTOME 3.320E-9 1.012E-8 4.800E-8 2.125E-7 5 24
22 SMP00375 Verapamil Pathway SMPDB 5.809E-9 1.616E-8 7.668E-8 3.718E-7 6 57
23 SMP00359 Diltiazem Pathway SMPDB 5.809E-9 1.616E-8 7.668E-8 3.718E-7 6 57
24 1339119 Phase 2 - plateau phase BioSystems: REACTOME 7.622E-9 2.033E-8 9.642E-8 4.878E-7 5 28
25 1269341 Platelet homeostasis BioSystems: REACTOME 3.218E-6 8.237E-6 3.908E-5 2.059E-4 5 91
26 217716 Cholinergic synapse BioSystems: KEGG 8.936E-6 2.200E-5 1.043E-4 5.719E-4 5 112
27 96530 Vascular smooth muscle contraction BioSystems: KEGG 1.303E-5 3.088E-5 1.465E-4 8.337E-4 5 121
28 983748 cGMP-PKG signaling pathway BioSystems: KEGG 5.473E-5 1.251E-4 5.935E-4 3.503E-3 5 163
29 PW:0000060 long term potentiation Pathway Ontology 2.278E-4 5.028E-4 2.385E-3 1.458E-2 2 9
30 PW:0000455 Excitatory synaptic transmission Pathway Ontology 2.843E-4 6.066E-4 2.878E-3 1.820E-2 2 10
31 172847 Protein digestion and absorption BioSystems: KEGG 1.557E-3 3.214E-3 1.525E-2
9.964E-2
 3 90
32 1270325 Interaction between L1 and Ankyrins BioSystems: REACTOME 2.662E-3 5.324E-3 2.525E-2
1.704E-1
 2 30
33 154409 Gastric acid secretion BioSystems: KEGG 1.580E-2 3.065E-2
1.454E-1
1.000E0
 2 75
34 153376 Salivary secretion BioSystems: KEGG 2.227E-2 3.389E-2
1.608E-1
1.000E0
 2 90
35 169306 Pancreatic secretion BioSystems: KEGG 2.512E-2 3.389E-2
1.608E-1
1.000E0
 2 96
36 SMP00400 Oxybuprocaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
37 SMP00395 Cocaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
38 SMP00396 Dibucaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
39 SMP00404 Ropivacaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
40 SMP00401 Prilocaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
41 SMP00394 Chloroprocaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
42 SMP00397 Levobupivacaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
43 SMP00402 Procaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
44 SMP00398 Lidocaine (Local Anaesthetic) Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
45 SMP00399 Mepivacaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
46 SMP00393 Bupivacaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
47 SMP00392 Benzocaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
48 SMP00403 Proparacaine Pathway SMPDB 2.542E-2 3.389E-2
1.608E-1
1.000E0
 1 10
49 1270323 L1CAM interactions BioSystems: REACTOME 2.810E-2 3.671E-2
1.741E-1
1.000E0
 2 102
50 525336 Serotonergic synapse BioSystems: KEGG 3.393E-2 4.343E-2
2.060E-1
1.000E0
 2 113
Show 45 more annotations

8: Pubmed [Display Chart] 32 input genes in category / 3392 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16985003 Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Pubmed 6.315E-66 2.142E-62 1.865E-61 2.142E-62 28 137
2 16382104 International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pubmed 2.269E-44 3.849E-41 3.351E-40 7.697E-41 17 40
3 25798587 Ion channel expression in the developing enteric nervous system. Pubmed 1.347E-32 1.523E-29 1.326E-28 4.568E-29 13 36
4 1383027 Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. Pubmed 1.715E-20 1.454E-17 1.266E-16 5.818E-17 7 10
5 7905852 Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. Pubmed 4.558E-20 3.092E-17 2.692E-16 1.546E-16 8 23
6 20943905 Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. Pubmed 2.103E-19 1.019E-16 8.872E-16 7.133E-16 6 6
7 9286706 Physical mapping of potassium channel gene clusters on mouse chromosomes three and six. Pubmed 2.103E-19 1.019E-16 8.872E-16 7.133E-16 6 6
8 27619418 Pore size matters for potassium channel conductance. Pubmed 1.471E-18 6.238E-16 5.431E-15 4.990E-15 6 7
9 12435606 N-terminal PDZ-binding domain in Kv1 potassium channels. Pubmed 5.881E-18 2.217E-15 1.930E-14 1.995E-14 6 8
10 8034307 Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome. Pubmed 1.675E-16 5.682E-14 4.947E-13 5.682E-13 7 28
11 20132415 The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Pubmed 2.974E-16 7.761E-14 6.757E-13 1.009E-12 5 5
12 10428084 Subunit composition of Kv1 channels in human CNS. Pubmed 2.974E-16 7.761E-14 6.757E-13 1.009E-12 5 5
13 19204046 {beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia. Pubmed 2.974E-16 7.761E-14 6.757E-13 1.009E-12 5 5
14 26378152 LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Pubmed 6.026E-16 1.421E-13 1.238E-12 2.044E-12 7 33
15 10758170 HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Pubmed 6.286E-16 1.421E-13 1.238E-12 2.132E-12 6 14
16 20533308 Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting. Pubmed 1.784E-15 3.184E-13 2.772E-12 6.050E-12 5 6
17 18603586 Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). Pubmed 1.784E-15 3.184E-13 2.772E-12 6.050E-12 5 6
18 14686897 Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly. Pubmed 1.784E-15 3.184E-13 2.772E-12 6.050E-12 5 6
19 21730298 Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia. Pubmed 1.784E-15 3.184E-13 2.772E-12 6.050E-12 5 6
20 9852577 Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. Pubmed 6.239E-15 1.058E-12 9.212E-12 2.116E-11 5 7
21 21859894 KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. Pubmed 1.663E-14 2.686E-12 2.338E-11 5.640E-11 5 8
22 28283561 Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness. Pubmed 2.346E-13 3.617E-11 3.149E-10 7.957E-10 5 12
23 12944270 KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
24 12136044 New disguises for an old channel: MaxiK channel beta-subunits. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
25 10219239 MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
26 23890619 Postmortem molecular analysis of KCNQ1, KCNH2, KCNE1 and KCNE2 genes in sudden unexplained nocturnal death syndrome in the Chinese Han population. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
27 14661677 Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
28 16239150 The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
29 16487223 Genetic polymorphisms in KCNQ1, HERG, KCNE1 and KCNE2 genes in the Chinese, Malay and Indian populations of Singapore. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
30 10792058 A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
31 16487842 Effect of clinical phenotype on yield of long QT syndrome genetic testing. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
32 12524525 A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
33 12388098 Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
34 15746444 Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
35 10692449 Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
36 10713961 Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. Pubmed 4.057E-13 3.822E-11 3.328E-10 1.376E-9 4 4
37 23542581 Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis. Pubmed 5.923E-13 5.430E-11 4.728E-10 2.009E-9 5 14
38 11289718 Correlation of genetic etiology with response to beta-adrenergic blockade among symptomatic patients with familial long-QT syndrome. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
39 19149796 Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
40 19716085 Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
41 17534376 Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
42 15840476 Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
43 23714088 Do LQTS gene single nucleotide polymorphisms alter QTc intervals at rest and during exercise stress testing? Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
44 16818214 Allelic dropout in long QT syndrome genetic testing: a possible mechanism underlying false-negative results. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
45 20108749 The electrocardiographic abnormalities in highly trained athletes compared to the genetic study related to causes of unexpected sudden cardiac death. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
46 19322600 Contribution of long-QT syndrome genetic variants in sudden infant death syndrome. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
47 20386770 Torsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
48 16303284 Expression and transcriptional control of human KCNE genes. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
49 21063070 Cardiac ion channel gene mutations in Greek long QT syndrome patients. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
50 21233214 Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. Pubmed 2.027E-12 1.146E-10 9.978E-10 6.876E-9 4 5
Show 45 more annotations

9: Interaction [Display Chart] 30 input genes in category / 466 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KCNA3 KCNA3 interactions 2.157E-15 7.364E-13 4.951E-12 1.005E-12 7 21
2 int:KCNA2 KCNA2 interactions 3.161E-15 7.364E-13 4.951E-12 1.473E-12 7 22
3 int:KCNE4 KCNE4 interactions 6.385E-15 9.918E-13 6.667E-12 2.975E-12 6 11
4 int:KCND2 KCND2 interactions 1.376E-12 1.603E-10 1.077E-9 6.411E-10 6 23
5 int:KCNA4 KCNA4 interactions 3.127E-12 2.914E-10 1.959E-9 1.457E-9 6 26
6 int:KCNA1 KCNA1 interactions 4.514E-12 3.506E-10 2.357E-9 2.104E-9 5 11
7 int:KCNIP2 KCNIP2 interactions 7.730E-12 5.146E-10 3.459E-9 3.602E-9 5 12
8 int:KCNAB2 KCNAB2 interactions 3.117E-11 1.816E-9 1.221E-8 1.453E-8 6 37
9 int:KCNQ1 KCNQ1 interactions 1.499E-10 7.761E-9 5.218E-8 6.985E-8 5 20
10 int:KCNQ3 KCNQ3 interactions 2.336E-10 9.898E-9 6.654E-8 1.089E-7 4 7
11 int:KCNIP1 KCNIP1 interactions 2.336E-10 9.898E-9 6.654E-8 1.089E-7 4 7
12 int:GOLM1 GOLM1 interactions 8.014E-9 3.112E-7 2.092E-6 3.735E-6 5 42
13 int:KCNB1 KCNB1 interactions 3.185E-8 1.074E-6 7.222E-6 1.484E-5 4 20
14 int:KCNA5 KCNA5 interactions 3.227E-8 1.074E-6 7.222E-6 1.504E-5 5 55
15 int:KCNE2 KCNE2 interactions 4.381E-8 1.361E-6 9.150E-6 2.042E-5 3 5
16 int:KCNE1 KCNE1 interactions 1.530E-7 4.456E-6 2.996E-5 7.130E-5 3 7
17 int:DLG4 DLG4 interactions 2.959E-7 8.111E-6 5.452E-5 1.379E-4 7 274
18 int:KCNQ2 KCNQ2 interactions 7.180E-7 1.859E-5 1.250E-4 3.346E-4 3 11
19 int:KCNA6 KCNA6 interactions 9.562E-7 2.345E-5 1.577E-4 4.456E-4 3 12
20 int:DLG1 DLG1 interactions 1.064E-6 2.480E-5 1.667E-4 4.959E-4 5 110
21 int:CALM1 CALM1 interactions 1.364E-6 3.026E-5 2.034E-4 6.355E-4 7 344
22 int:DOLK DOLK interactions 2.423E-6 5.132E-5 3.450E-4 1.129E-3 3 16
23 int:KCNIP4 KCNIP4 interactions 2.939E-6 5.954E-5 4.003E-4 1.369E-3 3 17
24 int:KCNAB1 KCNAB1 interactions 3.522E-6 6.839E-5 4.598E-4 1.641E-3 3 18
25 int:KCNH2 KCNH2 interactions 1.558E-5 2.903E-4 1.952E-3 7.258E-3 3 29
26 int:DPP10 DPP10 interactions 1.662E-5 2.979E-4 2.003E-3 7.746E-3 2 4
27 int:NEDD4L NEDD4L interactions 2.744E-5 4.736E-4 3.184E-3 1.279E-2 5 214
28 int:IL16 IL16 interactions 4.482E-5 7.460E-4 5.015E-3 2.089E-2 3 41
29 int:KCNRG KCNRG interactions 5.799E-5 9.008E-4 6.056E-3 2.702E-2 2 7
30 int:KCNMB1 KCNMB1 interactions 5.799E-5 9.008E-4 6.056E-3 2.702E-2 2 7
31 int:KCNQ4 KCNQ4 interactions 7.724E-5 1.161E-3 7.806E-3 3.600E-2 2 8
32 int:KCNH1 KCNH1 interactions 1.239E-4 1.804E-3 1.213E-2
5.773E-2
 2 10
33 int:KCNQ5 KCNQ5 interactions 1.512E-4 2.136E-3 1.436E-2
7.048E-2
 2 11
34 int:CALM3 CALM3 interactions 2.322E-4 3.183E-3 2.140E-2
1.082E-1
 3 71
35 int:NEU1 NEU1 interactions 3.283E-4 4.371E-3 2.938E-2
1.530E-1
 2 16
36 int:KCNA10 KCNA10 interactions 4.177E-4 5.406E-3 3.634E-2
1.946E-1
 2 18
37 int:SRC SRC interactions 5.435E-4 6.845E-3 4.602E-2
2.533E-1
 5 405
38 int:KCNIP3 KCNIP3 interactions 6.870E-4 8.425E-3
5.664E-2
3.201E-1
 2 23
39 int:CNTNAP1 CNTNAP1 interactions 7.487E-4 8.774E-3
5.898E-2
3.489E-1
 2 24
40 int:ACTN2 ACTN2 interactions 7.531E-4 8.774E-3
5.898E-2
3.510E-1
 3 106
41 int:ALG10 ALG10 interactions 8.129E-4 9.239E-3
6.211E-2
3.788E-1
 2 25
42 int:C1orf43 C1orf43 interactions 1.021E-3 1.133E-2
7.616E-2
4.758E-1
 2 28
43 int:TBXA2R TBXA2R interactions 1.252E-3 1.357E-2
9.122E-2
5.835E-1
 2 31
44 int:KCND3 KCND3 interactions 1.419E-3 1.503E-2
1.010E-1
6.611E-1
 2 33
45 int:KCNS3 KCNS3 interactions 1.595E-3 1.652E-2
1.111E-1
7.435E-1
 2 35
46 int:LEMD2 LEMD2 interactions 1.782E-3 1.791E-2
1.204E-1
8.304E-1
 2 37
47 int:STUB1 STUB1 interactions 1.806E-3 1.791E-2
1.204E-1
8.418E-1
 4 312
48 int:COL1A2 COL1A2 interactions 2.743E-3 2.640E-2
1.775E-1
1.000E0
 2 46
49 int:DLGAP1 DLGAP1 interactions 2.776E-3 2.640E-2
1.775E-1
1.000E0
 3 167
50 int:CALM2 CALM2 interactions 2.983E-3 2.726E-2
1.833E-1
1.000E0
 2 48
Show 45 more annotations

10: Cytoband [Display Chart] 31 input genes in category / 28 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21q22.12 21q22.12 1.044E-4 2.923E-3 1.148E-2 2.923E-3 2 17
2 12p13 12p13 1.602E-3 1.680E-2
6.598E-2
 4.487E-2 2 66
3 1p13.3 1p13.3 1.800E-3 1.680E-2
6.598E-2
5.040E-2
 2 70
4 3q26.3-q27 3q26.3-q27 2.681E-3 1.877E-2
7.370E-2
7.506E-2
 1 3
5 11p14 11p14 3.573E-3 2.001E-2
7.858E-2
1.000E-1
 1 4
6 6q14 6q14 6.244E-3 2.808E-2
1.103E-1
1.748E-1
 1 7
7 3q26.32 3q26.32 7.133E-3 2.808E-2
1.103E-1
1.997E-1
 1 8
8 5q22.3 5q22.3 8.022E-3 2.808E-2
1.103E-1
2.246E-1
 1 9
9 12p13.32 12p13.32 1.068E-2 3.323E-2
1.305E-1
2.991E-1
 1 12
10 1p36.3 1p36.3 1.245E-2 3.486E-2
1.369E-1
3.486E-1
 1 14
11 4p15.32 4p15.32 1.422E-2 3.523E-2
1.384E-1
3.981E-1
 1 16
12 1p13 1p13 1.510E-2 3.523E-2
1.384E-1
4.228E-1
 1 17
13 20q13.3 20q13.3 1.774E-2 3.821E-2
1.501E-1
4.968E-1
 1 20
14 2q36.1 2q36.1 1.950E-2 3.881E-2
1.524E-1
5.460E-1
 1 22
15 7q31 7q31 2.388E-2 3.881E-2
1.524E-1
6.686E-1
 1 27
16 1q32.2 1q32.2 2.475E-2 3.881E-2
1.524E-1
6.931E-1
 1 28
17 20q13.2 20q13.2 2.562E-2 3.881E-2
1.524E-1
7.175E-1
 1 29
18 8q24 8q24 2.562E-2 3.881E-2
1.524E-1
7.175E-1
 1 29
19 1p34 1p34 2.824E-2 3.881E-2
1.524E-1
7.907E-1
 1 32
20 5q34 5q34 2.911E-2 3.881E-2
1.524E-1
8.151E-1
 1 33
21 1p13.1 1p13.1 2.911E-2 3.881E-2
1.524E-1
8.151E-1
 1 33
22 10q24 10q24 3.085E-2 3.926E-2
1.542E-1
8.637E-1
 1 35
23 10q22.3 10q22.3 4.035E-2 4.912E-2
1.929E-1
1.000E0
 1 46
Show 18 more annotations

11: Transcription Factor Binding Site [Display Chart] 28 input genes in category / 282 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NGFIC 01 V$NGFIC 01 1.621E-5 4.570E-3 2.843E-2 4.570E-3 6 197
2 V$MYOD Q6 01 V$MYOD Q6 01 2.035E-4 2.870E-2
1.785E-1
5.739E-2
 5 195

12: Gene Family [Display Chart] 32 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 274 Potassium voltage-gated channels genenames.org 6.736E-39 5.389E-38 1.465E-37 5.389E-38 17 40
2 858 Potassium voltage-gated channel regulatory subunits|EF-hand domain containing genenames.org 2.258E-19 9.031E-19 2.455E-18 1.806E-18 8 15
3 857 Potassium calcium-activated channel subfamily M regulatory beta subunits genenames.org 7.879E-12 2.101E-11 5.710E-11 6.303E-11 4 4
4 255 Potassium calcium-activated channels genenames.org 9.849E-8 1.970E-7 5.354E-7 7.879E-7 3 6
5 863 EF-hand domain containing genenames.org 6.597E-3 1.056E-2 2.869E-2
5.278E-2
 3 219
6 399 Aldo-keto reductases genenames.org 2.607E-2 3.476E-2
9.447E-2
2.086E-1
 1 15
Show 1 more annotation

13: Coexpression [Display Chart] 32 input genes in category / 1742 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19658189-TableS8d Human EmbryonicStemCell Xu09 85genes GeneSigDB 1.650E-15 2.875E-12 2.311E-11 2.875E-12 9 83
2 M1954 Genes with high-CpG-density promoters (HCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.066E-9 4.412E-6 3.548E-5 8.824E-6 9 434
3 15785748-Table3 Human Uterine Santin05 178genes GeneSigDB 5.437E-5 3.157E-2
2.539E-1
9.472E-2
 4 151
4 M7327 Genes down-regulated in neurons after NPAS4 [GeneID=266743] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.133E-4 4.679E-2
3.762E-1
1.974E-1
 3 68
5 M3094 Genes up-regulated in comparison of healthy B cells versus systemic lupus erythematosus B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.551E-4 4.679E-2
3.762E-1
2.701E-1
 4 198
6 M7166 Genes up-regulated in memory CD8 T cells: wildtype wt versus ZBTB7B [GeneID=51043] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.612E-4 4.679E-2
3.762E-1
2.808E-1
 4 200
Show 1 more annotation

14: Coexpression Atlas [Display Chart] 31 input genes in category / 1572 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap 1.361E-8 2.139E-5 1.698E-4 2.139E-5 9 476
2 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap 2.232E-7 1.356E-4 1.076E-3 3.509E-4 7 312
3 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup9 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup9 Top 200 Genes BrainMap 3.129E-7 1.356E-4 1.076E-3 4.919E-4 7 328
4 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k2 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.756E-7 1.356E-4 1.076E-3 5.904E-4 7 337
5 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Slc17a7 Top 200 Genes BrainMap 4.313E-7 1.356E-4 1.076E-3 6.780E-4 7 344
6 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Top 200 BrainMap 1.350E-6 3.031E-4 2.406E-3 2.122E-3 6 254
7 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Subtype Neuron.excitatory.Slc17a6.Rora Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Subtype Neuron.excitatory.Slc17a6.Rora Top 200 Genes BrainMap 1.350E-6 3.031E-4 2.406E-3 2.122E-3 6 254
8 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap 4.427E-6 7.007E-4 5.562E-3 6.960E-3 6 312
9 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Slc17a8 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Slc17a8 BrainMap 5.011E-6 7.007E-4 5.562E-3 7.877E-3 5 179
10 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup2 Top 200 Genes BrainMap 5.305E-6 7.007E-4 5.562E-3 8.340E-3 6 322
11 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap 5.400E-6 7.007E-4 5.562E-3 8.489E-3 6 323
12 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap 5.795E-6 7.007E-4 5.562E-3 9.109E-3 6 327
13 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb Top 200 Genes BrainMap 5.795E-6 7.007E-4 5.562E-3 9.109E-3 6 327
14 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Nefm Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Nefm Top 200 Genes BrainMap 6.653E-6 7.471E-4 5.930E-3 1.046E-2 6 335
15 GSM399367 500 alpha beta T cells, T.4int8+.Th, 4int 8+ TCRhi, Thymus, avg-3 Immgen.org, GSE15907 5.034E-5 4.946E-3 3.926E-2
7.914E-2
 5 289
16 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Nnat Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Nnat Top 200 Genes BrainMap 5.034E-5 4.946E-3 3.926E-2
7.914E-2
 5 289
17 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 GlobusPallidus Top 200 Genes BrainMap 5.916E-5 5.470E-3 4.342E-2
9.299E-2
 5 299
18 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Gad1,Gad2 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Gad1,Gad2 Top 200 Genes 7.345E-5 6.414E-3
5.091E-2
1.155E-1
 5 313
19 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup3 Inhibitory.subGroup3 Subtype Inhibitory.subGroup3 Thalamus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup3 Inhibitory.subGroup3 Subtype Inhibitory.subGroup3 Thalamus Top 200 Genes BrainMap 8.152E-5 6.598E-3
5.238E-2
1.282E-1
 5 320
20 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes 8.395E-5 6.598E-3
5.238E-2
1.320E-1
 5 322
21 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma TCGA-Bone and Soft Tissue 9.919E-5 7.425E-3
5.894E-2
1.559E-1
 4 172
22 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/5 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/5 TCGA-Esophagus 1.108E-4 7.517E-3
5.967E-2
1.742E-1
 4 177
23 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup7/Rora BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup7/Rora BrainMap 1.108E-4 7.517E-3
5.967E-2
1.742E-1
 4 177
24 BM Top 100 - cerebellum BM Top 100 - cerebellum Body Map 1.275E-4 7.517E-3
5.967E-2
2.005E-1
 3 69
25 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Overall Top 200 Genes BrainMap 1.341E-4 7.517E-3
5.967E-2
2.109E-1
 4 186
26 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap 1.398E-4 7.517E-3
5.967E-2
2.197E-1
 4 188
27 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap 1.398E-4 7.517E-3
5.967E-2
2.197E-1
 4 188
28 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6 Top 200 Genes 1.398E-4 7.517E-3
5.967E-2
2.198E-1
 5 359
29 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Overall Top 200 Genes BrainMap 1.426E-4 7.517E-3
5.967E-2
2.242E-1
 4 189
30 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap 1.485E-4 7.517E-3
5.967E-2
2.335E-1
 4 191
31 BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Top 200 BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Top 200 BrainMap 1.530E-4 7.517E-3
5.967E-2
2.405E-1
 5 366
32 BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Subtype Mural.Acta2.Rgs5.Acta2,Rgs5. PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Subtype Mural.Acta2.Rgs5.Acta2,Rgs5. PosteriorCortex Top 200 Genes BrainMap 1.530E-4 7.517E-3
5.967E-2
2.405E-1
 5 366
33 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr PosteriorCortex Top 200 Genes BrainMap 1.630E-4 7.765E-3
6.164E-2
2.562E-1
 5 371
34 BM Top 100 - parietal lobe BM Top 100 - parietal lobe Body Map 1.699E-4 7.857E-3
6.237E-2
2.672E-1
 3 76
35 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/5/3 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/5/3 TCGA-Brain 1.757E-4 7.893E-3
6.265E-2
2.763E-1
 2 14
36 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k1 1000 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-6689 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.421E-4 1.057E-2
8.392E-2
3.806E-1
 4 217
37 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k5 1000 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.711E-4 1.152E-2
9.143E-2
4.262E-1
 3 89
38 smooth muscle smooth muscle Human Protein Atlas 2.802E-4 1.159E-2
9.201E-2
4.405E-1
 3 90
39 adrenal gland adrenal gland Human Protein Atlas 4.020E-4 1.584E-2
1.257E-1
6.319E-1
 4 248
40 gudmap developingLowerUrinaryTract e14.5 urogenital sinus 500 k3 DevelopingLowerUrinaryTract e14.5 urogenital sinus emap-5517 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.030E-4 1.584E-2
1.257E-1
6.336E-1
 2 21
41 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/ Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/ Tabula Muris Consortium 4.166E-4 1.597E-2
1.268E-1
6.549E-1
 3 103
42 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Top 200 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Top 200 BrainMap 4.308E-4 1.606E-2
1.275E-1
6.771E-1
 5 458
43 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Top 200 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Top 200 BrainMap 4.394E-4 1.606E-2
1.275E-1
6.907E-1
 5 460
44 gudmap developingKidney e15.5 Ureteral Smooth Musc 1000 k2 DevelopingKidney e15.5 Ureteral Smooth Musc emap-28812 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.537E-4 1.978E-2
1.570E-1
8.704E-1
 4 270
45 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup6 Top 200 Genes BrainMap 5.692E-4 1.988E-2
1.578E-1
8.948E-1
 4 272
46 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap 5.851E-4 1.999E-2
1.587E-1
9.198E-1
 4 274
47 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup3 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup3 Top 200 Genes BrainMap 6.604E-4 2.192E-2
1.740E-1
1.000E0
 4 283
48 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup3 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup3 Top 200 Genes BrainMap 6.692E-4 2.192E-2
1.740E-1
1.000E0
 4 284
49 Arv EB-LF 2500 K4 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 8.109E-4 2.562E-2
2.034E-1
1.000E0
 4 299
50 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap 8.313E-4 2.562E-2
2.034E-1
1.000E0
 4 301
Show 45 more annotations

15: Computational [Display Chart] 19 input genes in category / 108 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5770 MODULE 63 Porins / transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.070E-9 1.262E-7 6.641E-7 2.236E-7 8 211
2 M785 MODULE 316 Ion channels. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.336E-9 1.262E-7 6.641E-7 2.523E-7 6 70
3 M6788 MODULE 201 Genes in the cancer module 201. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.066E-4 3.836E-3 2.019E-2 1.151E-2 3 50
4 M7693 MODULE 500 Genes in the cancer module 500. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.431E-3 3.864E-2
2.034E-1
1.545E-1
 2 30

16: MicroRNA [Display Chart] 32 input genes in category / 887 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-330-5p:TargetScan hsa-miR-330-5p TargetScan 6.084E-7 2.698E-4 1.987E-3 5.397E-4 5 369
2 hsa-miR-326:TargetScan hsa-miR-326 TargetScan 6.084E-7 2.698E-4 1.987E-3 5.397E-4 5 369
3 hsa-miR-1305:PITA hsa-miR-1305:PITA TOP PITA 1.661E-6 4.911E-4 3.617E-3 1.473E-3 5 453
4 hsa-miR-934:PITA hsa-miR-934:PITA TOP PITA 1.131E-5 2.007E-3 1.478E-2 1.004E-2 3 97
5 hsa-miR-409-5p:TargetScan hsa-miR-409-5p TargetScan 1.131E-5 2.007E-3 1.478E-2 1.004E-2 3 97
6 hsa-miR-323a-3p:TargetScan hsa-miR-323a-3p TargetScan 1.996E-5 2.951E-3 2.173E-2 1.770E-2 4 362
7 hsa-miR-574-5p:Functional MTI Functional MTI miRTarbase 3.398E-5 3.842E-3 2.830E-2 3.014E-2 4 415
8 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 3.796E-5 3.842E-3 2.830E-2 3.367E-2 4 427
9 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 4.190E-5 3.842E-3 2.830E-2 3.717E-2 4 438
10 hsa-miR-197:PITA hsa-miR-197:PITA TOP PITA 4.331E-5 3.842E-3 2.830E-2 3.842E-2 3 152
11 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.024E-5 3.892E-3 2.866E-2 4.456E-2 4 459
12 hsa-miR-190b:TargetScan hsa-miR-190b TargetScan 5.728E-5 3.892E-3 2.866E-2
5.081E-2
 3 167
13 hsa-miR-190a-5p:TargetScan hsa-miR-190a-5p TargetScan 5.728E-5 3.892E-3 2.866E-2
5.081E-2
 3 167
14 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 6.468E-5 3.892E-3 2.866E-2
5.737E-2
 4 490
15 hsa-miR-1206:PITA hsa-miR-1206:PITA TOP PITA 6.581E-5 3.892E-3 2.866E-2
5.838E-2
 3 175
16 hsa-miR-6776-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.396E-5 4.655E-3 3.428E-2
7.447E-2
 3 190
17 hsa-miR-18a-5p:TargetScan hsa-miR-18a-5p TargetScan 1.457E-4 7.179E-3
5.288E-2
1.292E-1
 3 229
18 hsa-miR-18b-5p:TargetScan hsa-miR-18b-5p TargetScan 1.457E-4 7.179E-3
5.288E-2
1.292E-1
 3 229
19 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 2.140E-4 9.705E-3
7.148E-2
1.898E-1
 3 261
20 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 2.188E-4 9.705E-3
7.148E-2
1.941E-1
 3 263
21 hsa-miR-940:PITA hsa-miR-940:PITA TOP PITA 2.574E-4 1.016E-2
7.486E-2
2.283E-1
 3 278
22 hsa-miR-365a-3p:TargetScan hsa-miR-365a-3p TargetScan 2.769E-4 1.016E-2
7.486E-2
2.456E-1
 3 285
23 hsa-miR-365b-3p:TargetScan hsa-miR-365b-3p TargetScan 2.769E-4 1.016E-2
7.486E-2
2.456E-1
 3 285
24 hsa-miR-26b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.884E-4 1.016E-2
7.486E-2
2.558E-1
 2 56
25 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 3.032E-4 1.016E-2
7.486E-2
2.689E-1
 3 294
26 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 3.032E-4 1.016E-2
7.486E-2
2.689E-1
 3 294
27 CAAGGAT,MIR-362:MSigDB CAAGGAT,MIR-362:MSigDB MSigDB 3.094E-4 1.016E-2
7.486E-2
2.744E-1
 2 58
28 hsa-miR-512-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.506E-4 1.111E-2
8.181E-2
3.110E-1
 3 309
29 hsa-miR-190a-5p:Non-Functional MTI Non-Functional MTI miRTarbase 3.767E-4 1.152E-2
8.486E-2
3.341E-1
 2 64
30 GTGGTGA,MIR-197:MSigDB GTGGTGA,MIR-197:MSigDB MSigDB 4.006E-4 1.184E-2
8.724E-2
3.553E-1
 2 66
31 hsa-miR-153:PITA hsa-miR-153:PITA TOP PITA 4.751E-4 1.339E-2
9.866E-2
4.215E-1
 3 343
32 hsa-miR-499-3p:PITA hsa-miR-499-3p:PITA TOP PITA 4.832E-4 1.339E-2
9.866E-2
4.286E-1
 3 345
33 hsa-miR-1293:PITA hsa-miR-1293:PITA TOP PITA 5.033E-4 1.353E-2
9.964E-2
4.464E-1
 2 74
34 hsa-miR-4731-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.107E-4 1.593E-2
1.174E-1
5.417E-1
 3 374
35 hsa-miR-1225-5p:PITA hsa-miR-1225-5p:PITA TOP PITA 6.946E-4 1.704E-2
1.255E-1
6.161E-1
 2 87
36 hsa-miR-670-3p:TargetScan hsa-miR-670-3p TargetScan 7.525E-4 1.704E-2
1.255E-1
6.674E-1
 3 402
37 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 8.021E-4 1.704E-2
1.255E-1
7.115E-1
 3 411
38 hsa-miR-122*:mirSVR lowEffct hsa-miR-122*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.191E-4 1.704E-2
1.255E-1
7.266E-1
 3 414
39 hsa-miR-205-5p:TargetScan hsa-miR-205-5p TargetScan 8.480E-4 1.704E-2
1.255E-1
7.521E-1
 3 419
40 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 8.597E-4 1.704E-2
1.255E-1
7.625E-1
 3 421
41 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 8.597E-4 1.704E-2
1.255E-1
7.625E-1
 3 421
42 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 8.597E-4 1.704E-2
1.255E-1
7.625E-1
 3 421
43 hsa-miR-4433b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.621E-4 1.704E-2
1.255E-1
7.647E-1
 2 97
44 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 9.198E-4 1.704E-2
1.255E-1
8.159E-1
 3 431
45 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 9.198E-4 1.704E-2
1.255E-1
8.159E-1
 3 431
46 hsa-miR-579:PITA hsa-miR-579:PITA TOP PITA 9.446E-4 1.704E-2
1.255E-1
8.378E-1
 3 435
47 TCCAGAT,MIR-516-5P:MSigDB TCCAGAT,MIR-516-5P:MSigDB MSigDB 9.710E-4 1.704E-2
1.255E-1
8.613E-1
 2 103
48 hsa-miR-147b:mirSVR highEffct hsa-miR-147b:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.898E-4 1.704E-2
1.255E-1
8.779E-1
 2 104
49 hsa-miR-139-5p:Functional MTI Functional MTI miRTarbase 1.009E-3 1.704E-2
1.255E-1
8.947E-1
 2 105
50 TGCAAAC,MIR-452:MSigDB TGCAAAC,MIR-452:MSigDB MSigDB 1.009E-3 1.704E-2
1.255E-1
8.947E-1
 2 105
Show 45 more annotations

17: Drug [Display Chart] 32 input genes in category / 5696 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000003019 diazoxide Stitch 6.350E-56 3.617E-52 3.337E-51 3.617E-52 29 227
2 CID000001727 4-AP Stitch 2.329E-51 6.633E-48 6.119E-47 1.327E-47 28 258
3 CID000005413 tetraethylammonium Stitch 4.880E-47 9.266E-44 8.548E-43 2.780E-43 26 236
4 CID000002520 verapamil Stitch 8.383E-46 1.194E-42 1.101E-41 4.775E-42 29 490
5 CID000003184 E 4031 Stitch 1.007E-40 1.147E-37 1.059E-36 5.737E-37 18 54
6 CID000002798 clofilium Stitch 1.353E-40 1.285E-37 1.185E-36 7.708E-37 19 74
7 CID000093460 pyraclofos Stitch 6.907E-40 5.620E-37 5.184E-36 3.934E-36 20 106
8 CID000001065 quindine Stitch 1.825E-35 1.299E-32 1.198E-31 1.039E-31 21 219
9 CID000656732 XE991 Stitch 2.660E-30 1.683E-27 1.553E-26 1.515E-26 13 33
10 CID000003488 glibenclamide Stitch 3.351E-28 1.909E-25 1.761E-24 1.909E-24 20 382
11 CID000005253 sotalol Stitch 1.389E-27 7.190E-25 6.633E-24 7.909E-24 14 73
12 CID000104810 barium Stitch 2.306E-27 1.095E-24 1.010E-23 1.314E-23 16 148
13 CID000005673 AC1Q646P Stitch 2.732E-25 1.197E-22 1.104E-21 1.556E-21 12 47
14 CID000121846 chromanol 293B Stitch 1.111E-24 4.520E-22 4.170E-21 6.328E-21 11 33
15 CID000003355 flecainide Stitch 6.566E-23 2.493E-20 2.300E-19 3.740E-19 12 71
16 ctd:D013793 Thallium CTD 2.962E-21 1.054E-18 9.726E-18 1.687E-17 9 22
17 CID000214350 BMS-204352 Stitch 7.342E-21 2.460E-18 2.269E-17 4.182E-17 8 13
18 CID000003932 linopirdine Stitch 1.130E-20 3.577E-18 3.300E-17 6.439E-17 10 43
19 CID000121892 retigabine Stitch 3.839E-20 1.151E-17 1.062E-16 2.187E-16 10 48
20 CID000175064 LY97241 Stitch 1.881E-19 5.357E-17 4.942E-16 1.071E-15 7 9
21 CID000071329 dofetilide Stitch 7.404E-19 2.008E-16 1.853E-15 4.217E-15 10 63
22 ctd:D011188 Potassium CTD 1.500E-18 3.884E-16 3.583E-15 8.546E-15 11 106
23 ctd:C476437 N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide CTD 4.598E-18 1.139E-15 1.050E-14 2.619E-14 6 6
24 CID006603977 Psora-4 Stitch 8.932E-18 2.120E-15 1.955E-14 5.088E-14 7 13
25 CID000008932 digitoxigenine Stitch 1.764E-17 4.020E-15 3.708E-14 1.005E-13 9 51
26 CID000004697 AC1L1IR1 Stitch 3.076E-17 6.738E-15 6.216E-14 1.752E-13 9 54
27 CID000007168 benzanilide Stitch 5.937E-17 1.253E-14 1.155E-13 3.382E-13 7 16
28 CID000017248 tetrapentylammonium Stitch 1.008E-16 2.051E-14 1.892E-13 5.744E-13 7 17
29 CID000092890 4-chromanol Stitch 1.315E-16 2.505E-14 2.311E-13 7.492E-13 8 35
30 CID005183170 AC1NPPZW Stitch 1.320E-16 2.505E-14 2.311E-13 7.516E-13 10 103
31 CID000082320 1-EBIO Stitch 2.154E-16 3.957E-14 3.650E-13 1.227E-12 8 37
32 CID000127718 MK-499 Stitch 2.608E-16 4.642E-14 4.282E-13 1.485E-12 7 19
33 CID000142984 Pro-val Stitch 1.738E-15 3.000E-13 2.767E-12 9.898E-12 8 47
34 CID000002812 clotrimazole Stitch 3.856E-15 6.461E-13 5.960E-12 2.197E-11 10 143
35 CID000002156 amiodarone Stitch 1.210E-14 1.969E-12 1.816E-11 6.890E-11 10 160
36 CID000004552 Ns 1619 Stitch 1.345E-14 2.109E-12 1.946E-11 7.663E-11 7 31
37 CID000070970 methanesulfonanilide Stitch 1.370E-14 2.109E-12 1.946E-11 7.803E-11 6 14
38 CID000105153 rubidium Stitch 1.606E-14 2.408E-12 2.221E-11 9.149E-11 8 61
39 CID010948590 CID10948590 Stitch 2.331E-14 3.404E-12 3.140E-11 1.328E-10 5 6
40 CID000001341 AC1L1B9H Stitch 1.259E-13 1.792E-11 1.653E-10 7.169E-10 8 78
41 CID000179344 eslicarbazepine acetate Stitch 2.171E-13 2.876E-11 2.653E-10 1.237E-9 5 8
42 CID006918293 valrocemide Stitch 2.171E-13 2.876E-11 2.653E-10 1.237E-9 5 8
43 CID000010930 isovaleramide Stitch 2.171E-13 2.876E-11 2.653E-10 1.237E-9 5 8
44 CID000002247 astemizole Stitch 2.291E-13 2.965E-11 2.735E-10 1.305E-9 7 45
45 CID000016591 APDs Stitch 3.168E-13 4.011E-11 3.700E-10 1.805E-9 7 47
46 CID009543520 triphosphoinositide Stitch 2.582E-12 3.198E-10 2.950E-9 1.471E-8 10 273
47 CID000002073 NSC15627 Stitch 6.017E-12 7.170E-10 6.614E-9 3.427E-8 6 34
48 CID000004488 niflumic acid Stitch 6.042E-12 7.170E-10 6.614E-9 3.441E-8 8 125
49 CID000020382 tetradotoxin Stitch 7.972E-12 9.268E-10 8.549E-9 4.541E-8 11 428
50 CID000024587 Barium permanganate Stitch 9.989E-12 1.138E-9 1.050E-8 5.690E-8 8 133
Show 45 more annotations

18: Disease [Display Chart] 29 input genes in category / 581 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0023976 Long QT Syndrome DisGeNET Curated 9.286E-27 5.395E-24 3.746E-23 5.395E-24 14 68
2 C0035828 Romano-Ward Syndrome DisGeNET Curated 1.757E-17 5.103E-15 3.543E-14 1.021E-14 8 23
3 C0040479 Torsades de Pointes DisGeNET Curated 8.431E-16 1.633E-13 1.134E-12 4.898E-13 7 18
4 C1141890 Congenital long QT syndrome DisGeNET BeFree 3.100E-14 4.502E-12 3.126E-11 1.801E-11 7 28
5 C1720983 Channelopathies DisGeNET BeFree 4.899E-14 5.693E-12 3.953E-11 2.846E-11 8 56
6 C0022387 Jervell-Lange Nielsen Syndrome DisGeNET Curated 2.673E-13 2.588E-11 1.797E-10 1.553E-10 5 7
7 C0403654 Bladder outflow obstruction DisGeNET BeFree 8.269E-12 6.863E-10 4.765E-9 4.804E-9 4 4
8 C1852581 EPILEPSY, BENIGN NEONATAL, 2 DisGeNET Curated 1.237E-10 7.189E-9 4.991E-8 7.189E-8 4 6
9 C0270851 Benign neonatal epilepsy DisGeNET Curated 1.237E-10 7.189E-9 4.991E-8 7.189E-8 4 6
10 C3889476 Benign Familial Convulsion DisGeNET BeFree 1.237E-10 7.189E-9 4.991E-8 7.189E-8 4 6
11 C0004238 Atrial Fibrillation DisGeNET Curated 1.689E-10 8.923E-9 6.195E-8 9.815E-8 9 232
12 C1142166 Brugada Syndrome (disorder) DisGeNET Curated 1.931E-10 9.349E-9 6.491E-8 1.122E-7 6 47
13 C1563715 Andersen Syndrome DisGeNET Curated 2.546E-10 1.138E-8 7.899E-8 1.479E-7 5 21
14 C0042510 Ventricular Fibrillation DisGeNET Curated 2.485E-9 9.896E-8 6.871E-7 1.444E-6 5 32
15 C3150943 Long Qt Syndrome 2 DisGeNET Curated 2.705E-9 9.896E-8 6.871E-7 1.572E-6 4 11
16 C0038644 Sudden infant death syndrome DisGeNET Curated 2.725E-9 9.896E-8 6.871E-7 1.583E-6 6 72
17 C0039070 Syncope DisGeNET Curated 4.630E-9 1.582E-7 1.099E-6 2.690E-6 5 36
18 C0340489 Lone atrial fibrillation DisGeNET BeFree 5.847E-9 1.887E-7 1.310E-6 3.397E-6 4 13
19 C0151878 Prolonged QT interval DisGeNET Curated 1.937E-8 5.922E-7 4.112E-6 1.125E-5 4 17
20 C0391957 idiopathic epilepsy DisGeNET BeFree 3.928E-8 1.141E-6 7.922E-6 2.282E-5 4 20
21 C1843687 ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) DisGeNET Curated 5.916E-8 1.637E-6 1.136E-5 3.437E-5 4 22
22 C1631597 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) DisGeNET Curated 7.152E-8 1.889E-6 1.311E-5 4.156E-5 4 23
23 C0085612 Ventricular arrhythmia DisGeNET Curated 9.045E-8 2.285E-6 1.586E-5 5.255E-5 5 64
24 C2348199 Short Qt Syndrome DisGeNET BeFree 1.027E-7 2.386E-6 1.657E-5 5.966E-5 3 6
25 C0159020 Convulsions in the newborn DisGeNET BeFree 1.027E-7 2.386E-6 1.657E-5 5.966E-5 3 6
26 C0085298 Sudden Cardiac Death DisGeNET Curated 1.904E-7 4.255E-6 2.954E-5 1.106E-4 4 29
27 C0684219 Myokymia DisGeNET Curated 4.297E-7 9.247E-6 6.420E-5 2.497E-4 3 9
28 C0042514 Tachycardia, Ventricular DisGeNET Curated 8.000E-7 1.660E-5 1.153E-4 4.648E-4 4 41
29 C0030443 Familial Periodic Paralysis DisGeNET BeFree 1.456E-6 2.820E-5 1.958E-4 8.460E-4 3 13
30 C0235222 Diastolic hypertension DisGeNET BeFree 1.456E-6 2.820E-5 1.958E-4 8.460E-4 3 13
31 C1279412 periodic paralysis (finding) DisGeNET Curated 1.851E-6 3.469E-5 2.409E-4 1.075E-3 3 14
32 C0220669 Familial benign neonatal epilepsy DisGeNET Curated 2.311E-6 4.196E-5 2.913E-4 1.343E-3 3 15
33 C0339789 Congenital deafness DisGeNET Curated 2.501E-6 4.403E-5 3.057E-4 1.453E-3 6 226
34 C0543888 Epileptic encephalopathy DisGeNET Curated 3.059E-6 4.856E-5 3.371E-4 1.778E-3 4 57
35 OMIN:220400 JERVELL AND LANGE-NIELSEN SYNDROME 1; JLNS1 OMIM 3.092E-6 4.856E-5 3.371E-4 1.797E-3 2 2
36 C1837014 Atrial Fibrillation, Familial, 3 DisGeNET Curated 3.092E-6 4.856E-5 3.371E-4 1.797E-3 2 2
37 OMIN:607554 ATRIAL FIBRILLATION, FAMILIAL, 3; ATFB3 OMIM 3.092E-6 4.856E-5 3.371E-4 1.797E-3 2 2
38 C0030252 Palpitations DisGeNET Curated 4.130E-6 6.314E-5 4.384E-4 2.399E-3 3 18
39 C0018781 Noise-induced hearing loss DisGeNET Curated 7.756E-6 1.155E-4 8.022E-4 4.506E-3 3 22
40 C1719788 Episodic ataxia type 1 DisGeNET Curated 9.267E-6 1.346E-4 9.345E-4 5.384E-3 2 3
41 C0751785 Unverricht-Lundborg Syndrome DisGeNET Curated 1.825E-5 2.501E-4 1.737E-3 1.060E-2 3 29
42 C3698186 Cardiac channelopathy DisGeNET BeFree 1.851E-5 2.501E-4 1.737E-3 1.076E-2 2 4
43 C1865020 Short QT Syndrome 1 DisGeNET Curated 1.851E-5 2.501E-4 1.737E-3 1.076E-2 2 4
44 C0232197 Fibrillation DisGeNET BeFree 2.239E-5 2.891E-4 2.007E-3 1.301E-2 3 31
45 C0270853 Myoclonic Epilepsy, Juvenile DisGeNET Curated 2.239E-5 2.891E-4 2.007E-3 1.301E-2 3 31
46 C0238357 Hyperkalemic periodic paralysis DisGeNET Curated 3.082E-5 3.731E-4 2.590E-3 1.791E-2 2 5
47 C1859062 LONG QT SYNDROME 3 DisGeNET Curated 3.082E-5 3.731E-4 2.590E-3 1.791E-2 2 5
48 C0151879 Shortened QT interval DisGeNET Curated 3.082E-5 3.731E-4 2.590E-3 1.791E-2 2 5
49 C0027066 Myoclonus DisGeNET Curated 3.622E-5 4.294E-4 2.981E-3 2.104E-2 4 106
50 C0265246 Townes syndrome DisGeNET Curated 4.618E-5 5.160E-4 3.582E-3 2.683E-2 2 6
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