Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc321_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 10 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003777 microtubule motor activity 1.339E-6 1.339E-5 3.922E-5 1.339E-5 3 77
2 GO:0003774 motor activity 6.813E-6 3.406E-5 9.977E-5 6.813E-5 3 132
3 GO:0019894 kinesin binding 7.376E-5 1.850E-4 5.418E-4 7.376E-4 2 42
4 GO:0015631 tubulin binding 7.399E-5 1.850E-4 5.418E-4 7.399E-4 3 293
5 GO:0008017 microtubule binding 1.905E-3 3.810E-3 1.116E-2 1.905E-2 2 214
6 GO:0008432 JUN kinase binding 4.173E-3 6.955E-3 2.037E-2 4.173E-2 1 13
7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed 5.454E-3 7.618E-3 2.231E-2
5.454E-2
 1 17
8 GO:1990939 ATP-dependent microtubule motor activity 6.094E-3 7.618E-3 2.231E-2
6.094E-2
 1 19
Show 3 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 153 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0010970 transport along microtubule 1.910E-8 2.908E-6 1.632E-5 2.922E-6 4 113
2 GO:0030705 cytoskeleton-dependent intracellular transport 3.802E-8 2.908E-6 1.632E-5 5.816E-6 4 134
3 GO:0007018 microtubule-based movement 3.635E-7 1.854E-5 1.040E-4 5.561E-5 4 235
4 GO:0044782 cilium organization 5.397E-5 1.543E-3 8.656E-3 8.257E-3 3 263
5 GO:0042073 intraciliary transport 5.732E-5 1.543E-3 8.656E-3 8.771E-3 2 37
6 GO:0098840 protein transport along microtubule 6.050E-5 1.543E-3 8.656E-3 9.257E-3 2 38
7 GO:0008088 axo-dendritic transport 7.406E-5 1.619E-3 9.082E-3 1.133E-2 2 42
8 GO:1905152 positive regulation of voltage-gated sodium channel activity 3.222E-4 5.477E-3 3.073E-2 4.929E-2 1 1
9 GO:1905150 regulation of voltage-gated sodium channel activity 3.222E-4 5.477E-3 3.073E-2 4.929E-2 1 1
10 GO:0031503 protein-containing complex localization 5.973E-4 8.961E-3
5.028E-2
9.138E-2
 2 119
11 GO:0035617 stress granule disassembly 6.443E-4 8.961E-3
5.028E-2
9.857E-2
 1 2
12 GO:0072383 plus-end-directed vesicle transport along microtubule 2.253E-3 2.463E-2
1.382E-1
3.448E-1
 1 7
13 GO:0072386 plus-end-directed organelle transport along microtubule 2.253E-3 2.463E-2
1.382E-1
3.448E-1
 1 7
14 GO:0035735 intraciliary transport involved in cilium assembly 2.253E-3 2.463E-2
1.382E-1
3.448E-1
 1 7
15 GO:1902018 negative regulation of cilium assembly 2.897E-3 2.850E-2
1.599E-1
4.432E-1
 1 9
16 GO:0060271 cilium assembly 3.001E-3 2.850E-2
1.599E-1
4.591E-1
 2 269
17 GO:0031340 positive regulation of vesicle fusion 3.218E-3 2.850E-2
1.599E-1
4.923E-1
 1 10
18 GO:0032988 ribonucleoprotein complex disassembly 3.539E-3 2.850E-2
1.599E-1
5.415E-1
 1 11
19 GO:0007028 cytoplasm organization 3.539E-3 2.850E-2
1.599E-1
5.415E-1
 1 11
20 GO:1901673 regulation of mitotic spindle assembly 4.503E-3 3.280E-2
1.840E-1
6.889E-1
 1 14
21 GO:0010927 cellular component assembly involved in morphogenesis 4.640E-3 3.280E-2
1.840E-1
7.100E-1
 2 336
22 GO:2000651 positive regulation of sodium ion transmembrane transporter activity 4.824E-3 3.280E-2
1.840E-1
7.380E-1
 1 15
23 GO:0032230 positive regulation of synaptic transmission, GABAergic 5.145E-3 3.280E-2
1.840E-1
7.871E-1
 1 16
24 GO:0090169 regulation of spindle assembly 5.145E-3 3.280E-2
1.840E-1
7.871E-1
 1 16
25 GO:1902307 positive regulation of sodium ion transmembrane transport 6.427E-3 3.782E-2
2.122E-1
9.834E-1
 1 20
26 GO:0060236 regulation of mitotic spindle organization 6.427E-3 3.782E-2
2.122E-1
9.834E-1
 1 20
27 GO:0090224 regulation of spindle organization 7.068E-3 4.005E-2
2.247E-1
1.000E0
 1 22
28 GO:0030031 cell projection assembly 7.707E-3 4.211E-2
2.363E-1
1.000E0
 2 436
29 GO:1902116 negative regulation of organelle assembly 8.669E-3 4.573E-2
2.566E-1
1.000E0
 1 27
Show 24 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 25 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035253 ciliary rootlet 2.078E-9 5.195E-8 1.982E-7 5.195E-8 3 10
2 GO:0005871 kinesin complex 4.519E-7 5.649E-6 2.155E-5 1.130E-5 3 55
3 GO:0044441 ciliary part 1.685E-6 1.404E-5 5.357E-5 4.212E-5 4 353
4 GO:0005874 microtubule 3.561E-6 2.226E-5 8.494E-5 8.904E-5 4 426
5 GO:0005875 microtubule associated complex 1.056E-5 5.281E-5 2.015E-4 2.641E-4 3 156
6 GO:0016938 kinesin I complex 3.148E-4 1.312E-3 5.005E-3 7.869E-3 1 1
7 GO:0031514 motile cilium 7.117E-4 2.542E-3 9.699E-3 1.779E-2 2 133
8 GO:0097225 sperm midpiece 5.340E-3 1.669E-2
6.368E-2
1.335E-1
 1 17
9 GO:0030992 intraciliary transport particle B 6.280E-3 1.744E-2
6.657E-2
1.570E-1
 1 20
10 GO:0097228 sperm principal piece 7.219E-3 1.805E-2
6.887E-2
1.805E-1
 1 23
11 GO:0044295 axonal growth cone 9.095E-3 2.067E-2
7.888E-2
2.274E-1
 1 29
12 GO:0030990 intraciliary transport particle 1.003E-2 2.090E-2
7.975E-2
2.508E-1
 1 32
13 GO:0097542 ciliary tip 1.408E-2 2.708E-2
1.034E-1
3.521E-1
 1 45
14 GO:0036126 sperm flagellum 2.400E-2 4.285E-2
1.635E-1
5.999E-1
 1 77
Show 9 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 27 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007054 Hyperreflexia proximally 2.124E-4 5.736E-3 2.232E-2 5.736E-3 1 1
2 HP:0007002 Motor axonal neuropathy 2.974E-3 3.585E-2
1.395E-1
8.031E-2
 1 14
3 HP:0002267 Exaggerated startle response 4.249E-3 3.585E-2
1.395E-1
1.147E-1
 1 20
4 HP:0003390 Sensory axonal neuropathy 5.311E-3 3.585E-2
1.395E-1
1.434E-1
 1 25

5: Mouse Phenotype [Display Chart] 4 input genes in category / 43 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 46 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR002151 Kinesin light InterPro 5.127E-7 1.965E-5 8.678E-5 2.358E-5 2 4
2 IPR015390 Rabaptin Rab5-bd dom InterPro 1.281E-6 1.965E-5 8.678E-5 5.894E-5 2 6
3 PF09311 Rab5-bind Pfam 1.281E-6 1.965E-5 8.678E-5 5.894E-5 2 6
4 IPR013105 TPR 2 InterPro 1.040E-4 9.567E-4 4.226E-3 4.784E-3 2 50
5 PF07719 TPR 2 Pfam 1.040E-4 9.567E-4 4.226E-3 4.784E-3 2 50
6 IPR026644 CEP170 InterPro 3.203E-4 1.728E-3 7.631E-3 1.473E-2 1 1
7 IPR029600 IFT81 InterPro 3.203E-4 1.728E-3 7.631E-3 1.473E-2 1 1
8 IPR001440 TPR 1 InterPro 3.381E-4 1.728E-3 7.631E-3 1.555E-2 2 90
9 PF00515 TPR 1 Pfam 3.381E-4 1.728E-3 7.631E-3 1.555E-2 2 90
10 PF15308 CEP170 C Pfam 6.404E-4 2.606E-3 1.151E-2 2.946E-2 1 2
11 IPR029300 CEP170 C InterPro 6.404E-4 2.606E-3 1.151E-2 2.946E-2 1 2
12 SM00028 TPR SMART 6.930E-4 2.606E-3 1.151E-2 3.188E-2 2 129
13 IPR019734 TPR repeat InterPro 7.364E-4 2.606E-3 1.151E-2 3.388E-2 2 133
14 IPR013026 TPR-contain dom InterPro 9.352E-4 2.761E-3 1.220E-2 4.302E-2 2 150
15 IPR015792 Kinesin light repeat InterPro 9.605E-4 2.761E-3 1.220E-2 4.418E-2 1 3
16 PS01160 KINESIN LIGHT PROSITE 9.605E-4 2.761E-3 1.220E-2 4.418E-2 1 3
17 PS50005 TPR PROSITE 1.130E-3 2.888E-3 1.275E-2
5.198E-2
 2 165
18 PS50293 TPR REGION PROSITE 1.130E-3 2.888E-3 1.275E-2
5.198E-2
 2 165
19 1.25.40.10 - Gene3D 1.787E-3 4.326E-3 1.911E-2
8.219E-2
 2 208
20 PF13374 TPR 10 Pfam 1.920E-3 4.417E-3 1.951E-2
8.833E-2
 1 6
21 IPR011990 TPR-like helical dom InterPro 2.254E-3 4.938E-3 2.181E-2
1.037E-1
 2 234
22 IPR002885 Pentatricopeptide repeat InterPro 7.344E-3 1.536E-2
6.782E-2
3.378E-1
 1 23
23 SM00240 FHA SMART 8.935E-3 1.787E-2
7.893E-2
4.110E-1
 1 28
24 PF00498 FHA Pfam 9.888E-3 1.819E-2
8.036E-2
4.549E-1
 1 31
25 PS50006 FHA DOMAIN PROSITE 9.888E-3 1.819E-2
8.036E-2
4.549E-1
 1 31
26 IPR000253 FHA dom InterPro 1.148E-2 1.841E-2
8.133E-2
5.279E-1
 1 36
27 2.60.200.20 - Gene3D 1.148E-2 1.841E-2
8.133E-2
5.279E-1
 1 36
28 IPR019821 Kinesin motor CS InterPro 1.306E-2 1.841E-2
8.133E-2
6.008E-1
 1 41
29 IPR027640 Kinesin-like fam InterPro 1.369E-2 1.841E-2
8.133E-2
6.299E-1
 1 43
30 PF00225 Kinesin Pfam 1.401E-2 1.841E-2
8.133E-2
6.445E-1
 1 44
31 SM00129 KISc SMART 1.401E-2 1.841E-2
8.133E-2
6.445E-1
 1 44
32 3.40.850.10 - Gene3D 1.401E-2 1.841E-2
8.133E-2
6.445E-1
 1 44
33 IPR001752 Kinesin motor dom InterPro 1.401E-2 1.841E-2
8.133E-2
6.445E-1
 1 44
34 PS00411 KINESIN MOTOR 1 PROSITE 1.401E-2 1.841E-2
8.133E-2
6.445E-1
 1 44
35 PS50067 KINESIN MOTOR 2 PROSITE 1.401E-2 1.841E-2
8.133E-2
6.445E-1
 1 44
36 IPR008984 SMAD FHA domain InterPro 1.654E-2 2.113E-2
9.335E-2
7.609E-1
 1 52
37 PF00612 IQ Pfam 2.253E-2 2.765E-2
1.221E-1
1.000E0
 1 71
38 IPR009053 Prefoldin InterPro 2.284E-2 2.765E-2
1.221E-1
1.000E0
 1 72
39 SM00015 IQ SMART 2.567E-2 3.027E-2
1.337E-1
1.000E0
 1 81
40 IPR000048 IQ motif EF-hand-BS InterPro 2.848E-2 3.276E-2
1.447E-1
1.000E0
 1 90
41 PS50096 IQ PROSITE 2.942E-2 3.301E-2
1.458E-1
1.000E0
 1 93
Show 36 more annotations

7: Pathway [Display Chart] 5 input genes in category / 20 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269515 RHO GTPases activate KTN1 BioSystems: REACTOME 5.126E-9 1.025E-7 3.689E-7 1.025E-7 3 11
2 1269378 Kinesins BioSystems: REACTOME 3.819E-7 3.819E-6 1.374E-5 7.639E-6 3 43
3 1383042 COPI-dependent Golgi-to-ER retrograde traffic BioSystems: REACTOME 2.830E-6 1.887E-5 6.788E-5 5.660E-5 3 83
4 1269200 MHC class II antigen presentation BioSystems: REACTOME 5.434E-6 2.717E-5 9.775E-5 1.087E-4 3 103
5 1383041 Golgi-to-ER retrograde transport BioSystems: REACTOME 6.809E-6 2.724E-5 9.798E-5 1.362E-4 3 111
6 1269377 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 1.931E-5 6.438E-5 2.316E-4 3.863E-4 3 157
7 1383038 Intra-Golgi and retrograde Golgi-to-ER traffic BioSystems: REACTOME 2.910E-5 8.313E-5 2.991E-4 5.819E-4 3 180
8 1269509 RHO GTPase Effectors BioSystems: REACTOME 1.271E-4 3.178E-4 1.143E-3 2.542E-3 3 295
9 P00003 Alzheimer disease-amyloid secretase pathway PantherDB 2.657E-4 5.904E-4 2.124E-3 5.314E-3 2 65
10 1269507 Signaling by Rho GTPases BioSystems: REACTOME 3.885E-4 7.769E-4 2.795E-3 7.769E-3 3 430
11 375172 Salmonella infection BioSystems: KEGG 4.653E-4 8.460E-4 3.044E-3 9.306E-3 2 86
12 1268846 Cilium Assembly BioSystems: REACTOME 2.295E-3 3.824E-3 1.376E-2 4.589E-2 2 192
13 1268838 Organelle biogenesis and maintenance BioSystems: REACTOME 7.081E-3 1.089E-2 3.919E-2
1.416E-1
 2 341
14 1268747 Insulin processing BioSystems: REACTOME 1.120E-2 1.599E-2
5.754E-2
2.239E-1
 1 28
15 137919 N-cadherin signaling events BioSystems: Pathway Interaction Database 1.319E-2 1.758E-2
6.325E-2
2.637E-1
 1 33
16 1268853 Intraflagellar transport BioSystems: REACTOME 1.636E-2 2.045E-2
7.358E-2
3.272E-1
 1 41
17 1268746 Peptide hormone metabolism BioSystems: REACTOME 3.602E-2 4.238E-2
1.525E-1
7.204E-1
 1 91
18 1268847 Anchoring of the basal body to the plasma membrane BioSystems: REACTOME 3.953E-2 4.392E-2
1.580E-1
7.905E-1
 1 100
Show 13 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 264 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10491391 Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. Pubmed 2.154E-11 5.686E-9 3.500E-8 5.686E-9 3 5
2 19164528 Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Pubmed 4.307E-11 5.686E-9 3.500E-8 1.137E-8 3 6
3 9624122 Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. Pubmed 1.809E-10 1.592E-8 9.797E-8 4.775E-8 3 9
4 16018997 The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Pubmed 4.736E-10 2.501E-8 1.539E-7 1.250E-7 3 12
5 16301330 Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. Pubmed 4.736E-10 2.501E-8 1.539E-7 1.250E-7 3 12
6 19773350 Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. Pubmed 2.057E-8 9.049E-7 5.570E-6 5.430E-6 2 2
7 15324660 Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Pubmed 2.927E-8 1.104E-6 6.794E-6 7.726E-6 4 256
8 8786141 Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Pubmed 6.170E-8 1.810E-6 1.114E-5 1.629E-5 2 3
9 25855459 Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Pubmed 6.170E-8 1.810E-6 1.114E-5 1.629E-5 2 3
10 19861499 Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. Pubmed 1.234E-7 3.257E-6 2.005E-5 3.257E-5 2 4
11 21750526 Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility. Pubmed 2.056E-7 4.935E-6 3.038E-5 5.428E-5 2 5
12 17979178 A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. Pubmed 2.272E-7 4.998E-6 3.076E-5 5.998E-5 3 87
13 21335237 Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles. Pubmed 4.318E-7 8.768E-6 5.397E-5 1.140E-4 2 7
14 11969417 Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. Pubmed 7.400E-7 1.396E-5 8.589E-5 1.954E-4 2 9
15 19825938 Dynein and kinesin regulate stress-granule and P-body dynamics. Pubmed 9.250E-7 1.526E-5 9.394E-5 2.442E-4 2 10
16 21915095 A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. Pubmed 9.250E-7 1.526E-5 9.394E-5 2.442E-4 2 10
17 28625565 The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Pubmed 1.356E-6 2.106E-5 1.297E-4 3.581E-4 2 12
18 15161933 Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. Pubmed 1.626E-6 2.385E-5 1.468E-4 4.294E-4 3 167
19 19765186 Identification of novel spartin-interactors shows spartin is a multifunctional protein. Pubmed 3.513E-6 4.416E-5 2.718E-4 9.274E-4 2 19
20 24421332 The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Pubmed 3.513E-6 4.416E-5 2.718E-4 9.274E-4 2 19
21 15529118 Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Pubmed 3.513E-6 4.416E-5 2.718E-4 9.274E-4 2 19
22 22261722 Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Pubmed 9.544E-6 1.145E-4 7.049E-4 2.520E-3 2 31
23 20114047 Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Pubmed 2.613E-5 3.000E-4 1.846E-3 6.899E-3 2 51
24 15778465 Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Pubmed 8.743E-5 6.284E-4 3.868E-3 2.308E-2 2 93
25 25902401 Examining kinesin processivity within a general gating framework. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
26 11130971 Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
27 8606779 Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
28 30015159 Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
29 23402760 Dissect Kif5b in nuclear positioning during myogenesis: the light chain binding domain and the autoinhibitory peptide are both indispensable. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
30 24072715 Motor domain phosphorylation modulates kinesin-1 transport. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
31 25450690 Kinesin-1 translocation: Surprising differences between bovine brain and MCF7-derived microtubules. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
32 25676575 Identification of tail binding effect of kinesin-1 using an elastic network model. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
33 21925109 Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
34 10210276 Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
35 25537000 Decrypting the structural, dynamic, and energetic basis of a monomeric kinesin interacting with a tubulin dimer in three ATPase states by all-atom molecular dynamics simulation. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
36 22198464 A metal switch for controlling the activity of molecular motor proteins. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
37 28284467 Moonlighting Motors: Kinesin, Dynein, and Cell Polarity. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
38 17925227 Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
39 28460050 IFT81 as a Candidate Gene for Nonsyndromic Retinal Degeneration. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
40 20152113 Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
41 26884162 The light chains of kinesin-1 are autoinhibited. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
42 19242560 Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
43 18817524 Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
44 25818289 Kinesin's front head is gated by the backward orientation of its neck linker. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
45 22561200 KLC3 is involved in sperm tail midpiece formation and sperm function. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
46 19348763 The Kinesin-1 tail conformationally restricts the nucleotide pocket. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
47 29229862 A small-molecule activator of kinesin-1 drives remodeling of the microtubule network. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
48 28242773 Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
49 18579780 The kinesin-1 motor protein is regulated by a direct interaction of its head and tail. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
50 20071331 Microtubule-associated protein-like binding of the kinesin-1 tail to microtubules. Pubmed 1.571E-4 6.284E-4 3.868E-3 4.147E-2 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 437 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KIF5C KIF5C interactions 2.127E-7 4.448E-5 2.961E-4 9.296E-5 3 40
2 int:MYCL MYCL interactions 2.656E-7 4.448E-5 2.961E-4 1.161E-4 3 43
3 int:KIF5A KIF5A interactions 3.053E-7 4.448E-5 2.961E-4 1.334E-4 3 45
4 int:KLC4 KLC4 interactions 1.124E-6 1.228E-4 8.176E-4 4.912E-4 3 69
5 int:KLC3 KLC3 interactions 1.694E-6 1.331E-4 8.862E-4 7.404E-4 3 79
6 int:KLC2 KLC2 interactions 1.827E-6 1.331E-4 8.862E-4 7.986E-4 3 81
7 int:KLC1 KLC1 interactions 2.513E-6 1.516E-4 1.009E-3 1.098E-3 3 90
8 int:SYNE4 SYNE4 interactions 2.775E-6 1.516E-4 1.009E-3 1.213E-3 3 93
9 int:YWHAG YWHAG interactions 5.677E-6 2.757E-4 1.835E-3 2.481E-3 4 445
10 int:KIF5B KIF5B interactions 7.440E-6 3.167E-4 2.109E-3 3.251E-3 3 129
11 int:ODF2 ODF2 interactions 7.973E-6 3.167E-4 2.109E-3 3.484E-3 3 132
12 int:CENPJ CENPJ interactions 1.079E-5 3.930E-4 2.617E-3 4.716E-3 3 146
13 int:FGFR1OP FGFR1OP interactions 1.218E-5 4.094E-4 2.726E-3 5.322E-3 3 152
14 int:AZIN1 AZIN1 interactions 1.461E-5 4.561E-4 3.037E-3 6.385E-3 2 18
15 int:PPIL2 PPIL2 interactions 3.348E-5 9.341E-4 6.219E-3 1.463E-2 2 27
16 int:CROCC CROCC interactions 3.604E-5 9.341E-4 6.219E-3 1.575E-2 2 28
17 int:NINL NINL interactions 3.634E-5 9.341E-4 6.219E-3 1.588E-2 3 219
18 int:CCDC151 CCDC151 interactions 4.432E-5 1.076E-3 7.164E-3 1.937E-2 2 31
19 int:YWHAH YWHAH interactions 5.203E-5 1.197E-3 7.967E-3 2.274E-2 3 247
20 int:TRAK2 TRAK2 interactions 6.342E-5 1.352E-3 9.001E-3 2.772E-2 2 37
21 int:OFD1 OFD1 interactions 6.561E-5 1.352E-3 9.001E-3 2.867E-2 3 267
22 int:PCM1 PCM1 interactions 7.086E-5 1.352E-3 9.001E-3 3.097E-2 3 274
23 int:CEP128 CEP128 interactions 7.241E-5 1.352E-3 9.001E-3 3.164E-2 3 276
24 int:SPART SPART interactions 7.424E-5 1.352E-3 9.001E-3 3.244E-2 2 40
25 int:PPP4R3B PPP4R3B interactions 8.193E-5 1.432E-3 9.535E-3 3.580E-2 2 42
26 int:KPTN KPTN interactions 1.072E-4 1.802E-3 1.200E-2 4.686E-2 2 48
27 int:HAUS8 HAUS8 interactions 1.212E-4 1.961E-3 1.306E-2
5.295E-2
 2 51
28 int:IFT74 IFT74 interactions 1.359E-4 2.121E-3 1.412E-2
5.940E-2
 2 54
29 int:SERPINB2 SERPINB2 interactions 1.410E-4 2.125E-3 1.415E-2
6.163E-2
 2 55
30 int:PTPN23 PTPN23 interactions 1.515E-4 2.207E-3 1.470E-2
6.622E-2
 2 57
31 int:SLAIN2 SLAIN2 interactions 1.569E-4 2.212E-3 1.473E-2
6.857E-2
 2 58
32 int:MED4 MED4 interactions 1.633E-4 2.231E-3 1.485E-2
7.138E-2
 3 363
33 int:NEURL4 NEURL4 interactions 2.159E-4 2.858E-3 1.903E-2
9.436E-2
 2 68
34 int:NUP43 NUP43 interactions 2.223E-4 2.858E-3 1.903E-2
9.716E-2
 2 69
35 int:SNAP23 SNAP23 interactions 2.421E-4 2.862E-3 1.906E-2
1.058E-1
 2 72
36 int:YWHAB YWHAB interactions 2.427E-4 2.862E-3 1.906E-2
1.061E-1
 3 415
37 int:PRKAR2B PRKAR2B interactions 2.489E-4 2.862E-3 1.906E-2
1.088E-1
 2 73
38 int:CHRNA9 CHRNA9 interactions 2.489E-4 2.862E-3 1.906E-2
1.088E-1
 2 73
39 int:ARHGEF2 ARHGEF2 interactions 2.558E-4 2.866E-3 1.908E-2
1.118E-1
 2 74
40 int:CEP104 CEP104 interactions 2.627E-4 2.870E-3 1.911E-2
1.148E-1
 2 75
41 int:SASS6 SASS6 interactions 2.842E-4 2.957E-3 1.969E-2
1.242E-1
 2 78
42 int:VPS52 VPS52 interactions 2.842E-4 2.957E-3 1.969E-2
1.242E-1
 2 78
43 int:NDC80 NDC80 interactions 2.915E-4 2.963E-3 1.973E-2
1.274E-1
 2 79
44 int:COG6 COG6 interactions 2.990E-4 2.969E-3 1.977E-2
1.307E-1
 2 80
45 int:KIF2A KIF2A interactions 3.296E-4 3.201E-3 2.131E-2
1.440E-1
 2 84
46 int:RAB3IP RAB3IP interactions 3.953E-4 3.756E-3 2.501E-2
1.728E-1
 2 92
47 int:CEP120 CEP120 interactions 4.394E-4 4.085E-3 2.720E-2
1.920E-1
 2 97
48 int:SUGT1 SUGT1 interactions 5.545E-4 5.048E-3 3.361E-2
2.423E-1
 2 109
49 int:LCA5 LCA5 interactions 6.494E-4 5.791E-3 3.856E-2
2.838E-1
 2 118
50 int:BICDL2 BICDL2 interactions 6.778E-4 5.924E-3 3.944E-2
2.962E-1
 1 2
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10p11.22 10p11.22 2.767E-3 8.300E-3 2.034E-2 1.660E-2 1 16
2 3q12.3 3q12.3 2.767E-3 8.300E-3 2.034E-2 1.660E-2 1 16
3 12q24.13 12q24.13 4.665E-3 8.807E-3 2.158E-2 2.799E-2 1 27
4 19q13 19q13 5.872E-3 8.807E-3 2.158E-2 3.523E-2 1 34
5 11q13.2 11q13.2 8.625E-3 1.035E-2 2.536E-2
5.175E-2
 1 50
6 1q44 1q44 1.957E-2 1.957E-2 4.796E-2
1.174E-1
 1 114
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 2 input genes in category / 12 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TAANNYSGCG UNKNOWN TAANNYSGCG UNKNOWN 1.286E-2 4.413E-2
1.369E-1
1.543E-1
 1 63
2 YGCANTGCR UNKNOWN YGCANTGCR UNKNOWN 2.118E-2 4.413E-2
1.369E-1
2.541E-1
 1 104
3 WWTAAGGC UNKNOWN WWTAAGGC UNKNOWN 2.401E-2 4.413E-2
1.369E-1
2.881E-1
 1 118
4 GCCNNNWTAAR UNKNOWN GCCNNNWTAAR UNKNOWN 2.442E-2 4.413E-2
1.369E-1
2.930E-1
 1 120
5 V$ZF5 01 V$ZF5 01 3.912E-2 4.413E-2
1.369E-1
4.694E-1
 1 193
6 V$MYOD Q6 01 V$MYOD Q6 01 3.952E-2 4.413E-2
1.369E-1
4.743E-1
 1 195
7 V$AP2 Q6 V$AP2 Q6 4.073E-2 4.413E-2
1.369E-1
4.887E-1
 1 201
8 V$LMO2COM 01 V$LMO2COM 01 4.093E-2 4.413E-2
1.369E-1
4.911E-1
 1 202
9 V$TFIIA Q6 V$TFIIA Q6 4.313E-2 4.413E-2
1.369E-1
5.176E-1
 1 213
10 V$PAX4 03 V$PAX4 03 4.313E-2 4.413E-2
1.369E-1
5.176E-1
 1 213
11 V$PAX4 01 V$PAX4 01 4.393E-2 4.413E-2
1.369E-1
5.272E-1
 1 217
12 V$OLF1 01 V$OLF1 01 4.413E-2 4.413E-2
1.369E-1
5.296E-1
 1 218
Show 7 more annotations

12: Gene Family [Display Chart] 4 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 769 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 2.357E-4 7.070E-4 1.296E-3 7.070E-4 2 115
2 615 RAB, member RAS oncogene GTPases|Intraflagellar transport proteins|Bardet-Biedl syndrome associated genenames.org 5.266E-3 7.900E-3 1.448E-2 1.580E-2 1 24
3 622 Kinesins|Protein phosphatase 1 regulatory subunits genenames.org 1.008E-2 1.008E-2 1.847E-2 3.023E-2 1 46

13: Coexpression [Display Chart] 6 input genes in category / 412 annotations before applied cutoff / 23137 genes in category

No results to display

14: Coexpression Atlas [Display Chart] 6 input genes in category / 242 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 2 input genes in category / 9 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11233 GCM PPM1D Neighborhood of PPM1D MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.174E-3 3.617E-2
1.023E-1
 4.657E-2 1 26
2 M16631 GCM MAP1B Neighborhood of MAP1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.291E-2 3.617E-2
1.023E-1
1.162E-1
 1 65
3 M14067 GCM SUFU Neighborhood of SUFU MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.529E-2 3.617E-2
1.023E-1
1.376E-1
 1 77
4 M16691 GCM RBM8A Neighborhood of RBM8A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.608E-2 3.617E-2
1.023E-1
1.447E-1
 1 81
5 M1101 GCM ZNF198 Neighborhood of ZNF198 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.338E-2 3.802E-2
1.075E-1
2.104E-1
 1 118
6 M3543 GCM NCAM1 Neighborhood of NCAM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.534E-2 3.802E-2
1.075E-1
2.281E-1
 1 128
7 M5805 GCM UBE2N Neighborhood of UBE2N MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.065E-2 3.845E-2
1.088E-1
2.758E-1
 1 155
8 M8150 GCM MYST2 Neighborhood of MYST2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.418E-2 3.845E-2
1.088E-1
3.076E-1
 1 173
Show 3 more annotations

16: MicroRNA [Display Chart] 6 input genes in category / 337 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3926:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.476E-6 4.976E-4 3.184E-3 4.976E-4 3 305
2 hsa-miR-142-3p.2:TargetScan hsa-miR-142-3p.2 TargetScan 4.104E-6 6.916E-4 4.425E-3 1.383E-3 3 429
3 hsa-miR-633:Functional MTI Functional MTI miRTarbase 1.857E-5 2.086E-3 1.335E-2 6.258E-3 2 81
4 hsa-miR-6771-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.844E-4 1.312E-2
8.396E-2
6.215E-2
 2 255
5 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 1.947E-4 1.312E-2
8.396E-2
6.560E-2
 2 262
6 hsa-miR-6742-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.635E-4 1.368E-2
8.751E-2
8.881E-2
 2 305
7 hsa-miR-1271:PITA hsa-miR-1271:PITA TOP PITA 3.585E-4 1.368E-2
8.751E-2
1.208E-1
 2 356
8 hsa-miR-96:PITA hsa-miR-96:PITA TOP PITA 3.625E-4 1.368E-2
8.751E-2
1.222E-1
 2 358
9 hsa-miR-450a-1-3p:Functional MTI Functional MTI miRTarbase 4.342E-4 1.368E-2
8.751E-2
1.463E-1
 2 392
10 hsa-miR-125b-5p:Functional MTI Functional MTI miRTarbase 5.243E-4 1.368E-2
8.751E-2
1.767E-1
 2 431
11 hsa-miR-939-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.438E-4 1.368E-2
8.751E-2
1.833E-1
 2 439
12 hsa-miR-1277:mirSVR highEffct hsa-miR-1277:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.687E-4 1.368E-2
8.751E-2
1.916E-1
 2 449
13 hsa-miR-598:mirSVR lowEffct hsa-miR-598:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.788E-4 1.368E-2
8.751E-2
1.951E-1
 2 453
14 hsa-miR-661:Functional MTI Functional MTI miRTarbase 5.941E-4 1.368E-2
8.751E-2
2.002E-1
 2 459
15 hsa-miR-4253:mirSVR highEffct hsa-miR-4253:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.439E-4 1.368E-2
8.751E-2
2.170E-1
 2 478
16 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 6.493E-4 1.368E-2
8.751E-2
2.188E-1
 2 480
17 hsa-miR-450a-5p:Functional MTI Functional MTI miRTarbase 1.411E-3 2.642E-2
1.691E-1
4.756E-1
 1 17
18 hsa-miR-4737:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.411E-3 2.642E-2
1.691E-1
4.756E-1
 1 17
19 hsa-miR-1247-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.743E-3 3.091E-2
1.978E-1
5.874E-1
 1 21
20 hsa-miR-381-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.992E-3 3.292E-2
2.107E-1
6.712E-1
 1 24
21 hsa-miR-6786-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.323E-3 3.292E-2
2.107E-1
7.830E-1
 1 28
22 hsa-miR-4791:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.152E-3 3.292E-2
2.107E-1
1.000E0
 1 38
23 hsa-miR-3201:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 3.292E-2
2.107E-1
1.000E0
 1 40
24 hsa-miR-1296:PITA hsa-miR-1296:PITA TOP PITA 3.318E-3 3.292E-2
2.107E-1
1.000E0
 1 40
25 hsa-miR-3945:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.401E-3 3.292E-2
2.107E-1
1.000E0
 1 41
26 GCAAGAC,MIR-431:MSigDB GCAAGAC,MIR-431:MSigDB MSigDB 3.566E-3 3.292E-2
2.107E-1
1.000E0
 1 43
27 hsa-miR-376c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.566E-3 3.292E-2
2.107E-1
1.000E0
 1 43
28 hsa-miR-376b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.566E-3 3.292E-2
2.107E-1
1.000E0
 1 43
29 hsa-miR-5684:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.897E-3 3.292E-2
2.107E-1
1.000E0
 1 47
30 hsa-miR-4512:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 3.292E-2
2.107E-1
1.000E0
 1 48
31 hsa-miR-7705:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 3.292E-2
2.107E-1
1.000E0
 1 52
32 hsa-miR-7160-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.477E-3 3.292E-2
2.107E-1
1.000E0
 1 54
33 hsa-miR-4686:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.477E-3 3.292E-2
2.107E-1
1.000E0
 1 54
34 hsa-miR-184:Functional MTI Functional MTI miRTarbase 4.560E-3 3.292E-2
2.107E-1
1.000E0
 1 55
35 hsa-miR-4473:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.292E-2
2.107E-1
1.000E0
 1 56
36 hsa-miR-892a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 3.292E-2
2.107E-1
1.000E0
 1 60
37 hsa-miR-6849-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 3.292E-2
2.107E-1
1.000E0
 1 61
38 hsa-miR-3681-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 3.292E-2
2.107E-1
1.000E0
 1 61
39 hsa-miR-3147:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.139E-3 3.292E-2
2.107E-1
1.000E0
 1 62
40 hsa-miR-3936:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 3.292E-2
2.107E-1
1.000E0
 1 64
41 hsa-miR-885-5p:Functional MTI Functional MTI miRTarbase 5.304E-3 3.292E-2
2.107E-1
1.000E0
 1 64
42 hsa-miR-6862-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 3.292E-2
2.107E-1
1.000E0
 1 68
43 hsa-miR-4253:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.292E-2
2.107E-1
1.000E0
 1 69
44 hsa-miR-520f-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 3.292E-2
2.107E-1
1.000E0
 1 69
45 hsa-miR-7852-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.292E-2
2.107E-1
1.000E0
 1 70
46 hsa-miR-1228*:mirSVR highEffct hsa-miR-1228*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.883E-3 3.292E-2
2.107E-1
1.000E0
 1 71
47 hsa-miR-6508-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 3.292E-2
2.107E-1
1.000E0
 1 74
48 hsa-miR-2054:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 3.292E-2
2.107E-1
1.000E0
 1 75
49 CAGGGTC,MIR-504:MSigDB CAGGGTC,MIR-504:MSigDB MSigDB 6.461E-3 3.292E-2
2.107E-1
1.000E0
 1 78
50 hsa-miR-2053:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.544E-3 3.292E-2
2.107E-1
1.000E0
 1 79
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 896 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000115349 Q AB Stitch 5.253E-4 3.455E-2
2.548E-1
4.707E-1
 1 2
2 CID000092880 methyl lithocholate Stitch 5.253E-4 3.455E-2
2.548E-1
4.707E-1
 1 2
3 CID000193328 Dimba Stitch 7.879E-4 3.455E-2
2.548E-1
7.059E-1
 1 3
4 CID000094203 methyl cholate Stitch 1.050E-3 3.455E-2
2.548E-1
9.412E-1
 1 4
5 4308 DN Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.053E-3 3.455E-2
2.548E-1
9.432E-1
 2 194
6 2185 DN Halcinonide [3093-35-4]; Down 200; 8.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.053E-3 3.455E-2
2.548E-1
9.432E-1
 2 194
7 1163 DN 2-propylpentanoic acid; Down 200; 50uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.063E-3 3.455E-2
2.548E-1
9.528E-1
 2 195
8 632 DN novobiocin sodium, USP; Down 200; 100uM; SKMEL5; HG-U133A Broad Institute CMAP Down 1.063E-3 3.455E-2
2.548E-1
9.528E-1
 2 195
9 3457 DN Hecogenin [467-55-0]; Down 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.063E-3 3.455E-2
2.548E-1
9.528E-1
 2 195
10 5447 DN Isradipine [75695-93-1]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 3.455E-2
2.548E-1
9.626E-1
 2 196
11 3524 DN Netilmicin sulfate [56931-57-2]; Down 200; 2.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 3.455E-2
2.548E-1
9.626E-1
 2 196
12 1182 DN estradiol, USP; Down 200; 0.01uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.074E-3 3.455E-2
2.548E-1
9.626E-1
 2 196
13 3453 DN Sulfameter [651-06-9]; Down 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 3.455E-2
2.548E-1
9.626E-1
 2 196
14 4739 DN Heliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.074E-3 3.455E-2
2.548E-1
9.626E-1
 2 196
15 6257 DN Cinoxacin [28657-80-9]; Down 200; 15.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.085E-3 3.455E-2
2.548E-1
9.723E-1
 2 197
16 6010 DN Triamterene [396-01-0]; Down 200; 15.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.085E-3 3.455E-2
2.548E-1
9.723E-1
 2 197
17 2958 DN Etomidate [33125-97-2]; Down 200; 16.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.085E-3 3.455E-2
2.548E-1
9.723E-1
 2 197
18 2972 DN Penbutolol sulfate [38363-32-5]; Down 200; 5.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.085E-3 3.455E-2
2.548E-1
9.723E-1
 2 197
19 7150 DN (+,-)-Synephrine [94-07-5]; Down 200; 24uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.085E-3 3.455E-2
2.548E-1
9.723E-1
 2 197
20 1470 DN Amiloride hydrochloride dihydrate [17440-83-4]; Down 200; 13.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.085E-3 3.455E-2
2.548E-1
9.723E-1
 2 197
21 3557 DN Ronidazole [7681-76-7]; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.096E-3 3.455E-2
2.548E-1
9.821E-1
 2 198
22 5286 DN Dichlorphenamide [120-97-8]; Down 200; 13.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.096E-3 3.455E-2
2.548E-1
9.821E-1
 2 198
23 5829 DN Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.096E-3 3.455E-2
2.548E-1
9.821E-1
 2 198
24 7095 UP SC 19220; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.096E-3 3.455E-2
2.548E-1
9.821E-1
 2 198
25 1510 DN Erythromycin [114-07-8]; Down 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.096E-3 3.455E-2
2.548E-1
9.821E-1
 2 198
26 1945 DN Azathioprine [446-86-6]; Down 200; 14.4uM; PC3; HG-U133A Broad Institute CMAP Down 1.107E-3 3.455E-2
2.548E-1
9.920E-1
 2 199
27 6148 DN 2-Chloropyrazine [14508-49-7]; Down 200; 35uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.107E-3 3.455E-2
2.548E-1
9.920E-1
 2 199
28 3430 DN Tinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.107E-3 3.455E-2
2.548E-1
9.920E-1
 2 199
29 7129 DN Drofenine hydrochloride [548-66-3]; Down 200; 11.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.118E-3 3.455E-2
2.548E-1
1.000E0
 2 200
Show 24 more annotations

18: Disease [Display Chart] 4 input genes in category / 15 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1836010 Spastic Paraplegia, Optic Atrophy, and Neuropathy DisGeNET Curated 4.936E-4 7.402E-3 2.456E-2 7.404E-3 1 2
2 C2845975 Malignant neuroendocrine tumor DisGeNET BeFree 1.234E-3 7.402E-3 2.456E-2 1.851E-2 1 5
3 C0393555 Pure hereditary spastic paraplegia DisGeNET BeFree 1.480E-3 7.402E-3 2.456E-2 2.221E-2 1 6
4 C0279557 Adenosquamous cell lung cancer DisGeNET BeFree 2.220E-3 8.013E-3 2.659E-2 3.330E-2 1 9
5 C1858712 Spastic paraplegia 10, autosomal dominant DisGeNET Curated 2.713E-3 8.013E-3 2.659E-2 4.069E-2 1 11
6 C1266002 Non-small cell carcinoma DisGeNET BeFree 3.205E-3 8.013E-3 2.659E-2 4.808E-2 1 13
7 C0854988 Adenocarcinoma of lung, stage IV DisGeNET BeFree 4.190E-3 8.979E-3 2.979E-2
6.285E-2
 1 17
8 C0037773 Spastic Paraplegia, Hereditary DisGeNET Curated 1.595E-2 2.821E-2
9.360E-2
2.392E-1
 1 65
9 C0080032 Pleural Effusion, Malignant DisGeNET BeFree 1.692E-2 2.821E-2
9.360E-2
2.539E-1
 1 69
10 C0007120 Bronchioloalveolar Adenocarcinoma DisGeNET Curated 1.887E-2 2.822E-2
9.364E-2
2.831E-1
 1 77
11 C0260037 Multiple tumors DisGeNET BeFree 2.082E-2 2.822E-2
9.364E-2
3.123E-1
 1 85
12 C0027868 Neuromuscular Diseases DisGeNET Curated 2.349E-2 2.822E-2
9.364E-2
3.523E-1
 1 96
13 C0034152 Henoch-Schoenlein Purpura DisGeNET Curated 2.446E-2 2.822E-2
9.364E-2
3.669E-1
 1 100
14 C0220650 Metastatic malignant neoplasm to brain DisGeNET BeFree 3.844E-2 4.118E-2
1.367E-1
5.766E-1
 1 158
Show 9 more annotations