Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc323_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 58 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003870 5-aminolevulinate synthase activity 8.615E-8 4.997E-6 2.322E-5 4.997E-6 2 2
2 GO:0050897 cobalt ion binding 2.410E-6 6.990E-5 3.248E-4 1.398E-4 2 8
3 GO:0008199 ferric iron binding 3.872E-6 7.487E-5 3.479E-4 2.246E-4 2 10
4 GO:0005506 iron ion binding 1.237E-5 1.794E-4 8.333E-4 7.174E-4 3 161
5 GO:0016749 N-succinyltransferase activity 3.990E-5 4.113E-4 1.911E-3 2.314E-3 2 31
6 GO:0016748 succinyltransferase activity 4.255E-5 4.113E-4 1.911E-3 2.468E-3 2 32
7 GO:0030170 pyridoxal phosphate binding 1.224E-4 1.014E-3 4.711E-3 7.098E-3 2 54
8 GO:0015099 nickel cation transmembrane transporter activity 3.215E-4 1.554E-3 7.220E-3 1.865E-2 1 1
9 GO:0070835 chromium ion transmembrane transporter activity 3.215E-4 1.554E-3 7.220E-3 1.865E-2 1 1
10 GO:0015094 lead ion transmembrane transporter activity 3.215E-4 1.554E-3 7.220E-3 1.865E-2 1 1
11 GO:0015086 cadmium ion transmembrane transporter activity 3.215E-4 1.554E-3 7.220E-3 1.865E-2 1 1
12 GO:0015100 vanadium ion transmembrane transporter activity 3.215E-4 1.554E-3 7.220E-3 1.865E-2 1 1
13 GO:0016410 N-acyltransferase activity 6.251E-4 2.486E-3 1.155E-2 3.625E-2 2 122
14 GO:0033570 transferrin transmembrane transporter activity 6.430E-4 2.486E-3 1.155E-2 3.729E-2 1 2
15 GO:0015087 cobalt ion transmembrane transporter activity 6.430E-4 2.486E-3 1.155E-2 3.729E-2 1 2
16 GO:0072510 trivalent inorganic cation transmembrane transporter activity 9.643E-4 3.290E-3 1.529E-2
5.593E-2
 1 3
17 GO:0015091 ferric iron transmembrane transporter activity 9.643E-4 3.290E-3 1.529E-2
5.593E-2
 1 3
18 GO:0015093 ferrous iron transmembrane transporter activity 1.607E-3 4.818E-3 2.239E-2
9.319E-2
 1 5
19 GO:0005375 copper ion transmembrane transporter activity 1.928E-3 4.818E-3 2.239E-2
1.118E-1
 1 6
20 GO:0016724 oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 1.928E-3 4.818E-3 2.239E-2
1.118E-1
 1 6
21 GO:0016151 nickel cation binding 1.928E-3 4.818E-3 2.239E-2
1.118E-1
 1 6
22 GO:0046870 cadmium ion binding 1.928E-3 4.818E-3 2.239E-2
1.118E-1
 1 6
23 GO:0004322 ferroxidase activity 1.928E-3 4.818E-3 2.239E-2
1.118E-1
 1 6
24 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups 1.994E-3 4.818E-3 2.239E-2
1.156E-1
 2 219
25 GO:0005384 manganese ion transmembrane transporter activity 2.249E-3 5.217E-3 2.424E-2
1.304E-1
 1 7
26 GO:0016746 transferase activity, transferring acyl groups 2.732E-3 6.095E-3 2.832E-2
1.585E-1
 2 257
27 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity 2.891E-3 6.210E-3 2.885E-2
1.677E-1
 1 9
28 GO:0048037 cofactor binding 3.166E-3 6.423E-3 2.984E-2
1.836E-1
 2 277
29 GO:0005381 iron ion transmembrane transporter activity 3.211E-3 6.423E-3 2.984E-2
1.863E-1
 1 10
30 GO:0016594 glycine binding 4.814E-3 9.307E-3 4.324E-2
2.792E-1
 1 15
31 GO:0016722 oxidoreductase activity, oxidizing metal ions 5.774E-3 1.080E-2
5.020E-2
3.349E-1
 1 18
32 GO:0008320 protein transmembrane transporter activity 6.094E-3 1.105E-2
5.132E-2
3.535E-1
 1 19
33 GO:0022884 macromolecule transmembrane transporter activity 7.054E-3 1.240E-2
5.760E-2
4.091E-1
 1 22
34 GO:0005385 zinc ion transmembrane transporter activity 7.373E-3 1.258E-2
5.844E-2
4.277E-1
 1 23
35 GO:0015295 solute:proton symporter activity 8.651E-3 1.434E-2
6.661E-2
5.018E-1
 1 27
36 GO:0035035 histone acetyltransferase binding 9.608E-3 1.548E-2
7.192E-2
5.573E-1
 1 30
37 GO:0046915 transition metal ion transmembrane transporter activity 1.343E-2 2.105E-2
9.782E-2
7.789E-1
 1 42
38 GO:0030145 manganese ion binding 1.629E-2 2.486E-2
1.155E-1
9.447E-1
 1 51
39 GO:0005507 copper ion binding 1.914E-2 2.846E-2
1.323E-1
1.000E0
 1 60
40 GO:0015294 solute:cation symporter activity 3.110E-2 4.510E-2
2.095E-1
1.000E0
 1 98
41 GO:0008565 protein transporter activity 3.204E-2 4.533E-2
2.106E-1
1.000E0
 1 101
42 GO:0015078 proton transmembrane transporter activity 3.454E-2 4.770E-2
2.216E-1
1.000E0
 1 109
43 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity 3.766E-2 4.965E-2
2.307E-1
1.000E0
 1 119
44 GO:0015399 primary active transmembrane transporter activity 3.766E-2 4.965E-2
2.307E-1
1.000E0
 1 119
Show 39 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 158 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0055072 iron ion homeostasis 6.334E-12 1.001E-9 5.647E-9 1.001E-9 5 77
2 GO:0055076 transition metal ion homeostasis 6.097E-11 4.817E-9 2.718E-8 9.634E-9 5 120
3 GO:0006879 cellular iron ion homeostasis 6.319E-10 3.328E-8 1.878E-7 9.984E-8 4 49
4 GO:0046916 cellular transition metal ion homeostasis 6.931E-9 2.738E-7 1.545E-6 1.095E-6 4 88
5 GO:0006783 heme biosynthetic process 3.283E-8 1.037E-6 5.854E-6 5.187E-6 3 23
6 GO:0006779 porphyrin-containing compound biosynthetic process 6.769E-8 1.782E-6 1.006E-5 1.069E-5 3 29
7 GO:0033014 tetrapyrrole biosynthetic process 9.185E-8 2.073E-6 1.170E-5 1.451E-5 3 32
8 GO:0042168 heme metabolic process 1.438E-7 2.840E-6 1.603E-5 2.272E-5 3 37
9 GO:0006778 porphyrin-containing compound metabolic process 2.806E-7 4.926E-6 2.780E-5 4.434E-5 3 46
10 GO:0046148 pigment biosynthetic process 5.118E-7 8.087E-6 4.563E-5 8.087E-5 3 56
11 GO:0006826 iron ion transport 6.641E-7 9.539E-6 5.383E-5 1.049E-4 3 61
12 GO:0033013 tetrapyrrole metabolic process 8.833E-7 1.163E-5 6.563E-5 1.396E-4 3 67
13 GO:0042440 pigment metabolic process 1.401E-6 1.703E-5 9.608E-5 2.213E-4 3 78
14 GO:0006782 protoporphyrinogen IX biosynthetic process 3.111E-6 3.511E-5 1.981E-4 4.916E-4 2 9
15 GO:0030218 erythrocyte differentiation 4.293E-6 4.522E-5 2.552E-4 6.783E-4 3 113
16 GO:0046501 protoporphyrinogen IX metabolic process 4.752E-6 4.546E-5 2.565E-4 7.508E-4 2 11
17 GO:0000041 transition metal ion transport 4.891E-6 4.546E-5 2.565E-4 7.728E-4 3 118
18 GO:0034101 erythrocyte homeostasis 5.542E-6 4.865E-5 2.745E-4 8.757E-4 3 123
19 GO:0097286 iron ion import 7.859E-6 6.535E-5 3.688E-4 1.242E-3 2 14
20 GO:0002262 myeloid cell homeostasis 9.864E-6 7.792E-5 4.397E-4 1.558E-3 3 149
21 GO:0051188 cofactor biosynthetic process 1.768E-5 1.330E-4 7.505E-4 2.793E-3 3 181
22 GO:0048872 homeostasis of number of cells 6.298E-5 4.523E-4 2.553E-3 9.951E-3 3 277
23 GO:0001666 response to hypoxia 8.973E-5 6.164E-4 3.478E-3 1.418E-2 3 312
24 GO:0036293 response to decreased oxygen levels 9.764E-5 6.428E-4 3.627E-3 1.543E-2 3 321
25 GO:0070482 response to oxygen levels 1.138E-4 7.192E-4 4.059E-3 1.798E-2 3 338
26 GO:0030099 myeloid cell differentiation 1.713E-4 1.041E-3 5.874E-3 2.706E-2 3 388
27 GO:0051186 cofactor metabolic process 2.002E-4 1.172E-3 6.611E-3 3.163E-2 3 409
28 GO:0015676 vanadium ion transport 3.222E-4 1.642E-3 9.266E-3
5.090E-2
 1 1
29 GO:0015692 lead ion transport 3.222E-4 1.642E-3 9.266E-3
5.090E-2
 1 1
30 GO:0035444 nickel cation transmembrane transport 3.222E-4 1.642E-3 9.266E-3
5.090E-2
 1 1
31 GO:0015675 nickel cation transport 3.222E-4 1.642E-3 9.266E-3
5.090E-2
 1 1
32 GO:0006880 intracellular sequestering of iron ion 6.443E-4 2.908E-3 1.641E-2
1.018E-1
 1 2
33 GO:1903181 positive regulation of dopamine biosynthetic process 6.443E-4 2.908E-3 1.641E-2
1.018E-1
 1 2
34 GO:0097577 sequestering of iron ion 6.443E-4 2.908E-3 1.641E-2
1.018E-1
 1 2
35 GO:1903179 regulation of dopamine biosynthetic process 6.443E-4 2.908E-3 1.641E-2
1.018E-1
 1 2
36 GO:0070574 cadmium ion transmembrane transport 1.288E-3 5.356E-3 3.023E-2
2.035E-1
 1 4
37 GO:1903874 ferrous iron transmembrane transport 1.288E-3 5.356E-3 3.023E-2
2.035E-1
 1 4
38 GO:0015691 cadmium ion transport 1.288E-3 5.356E-3 3.023E-2
2.035E-1
 1 4
39 GO:0048625 myoblast fate commitment 1.610E-3 6.205E-3 3.501E-2
2.544E-1
 1 5
40 GO:0070627 ferrous iron import 1.610E-3 6.205E-3 3.501E-2
2.544E-1
 1 5
41 GO:0003032 detection of oxygen 1.610E-3 6.205E-3 3.501E-2
2.544E-1
 1 5
42 GO:0045964 positive regulation of dopamine metabolic process 1.932E-3 6.635E-3 3.744E-2
3.052E-1
 1 6
43 GO:0032364 oxygen homeostasis 1.932E-3 6.635E-3 3.744E-2
3.052E-1
 1 6
44 GO:0045915 positive regulation of catecholamine metabolic process 1.932E-3 6.635E-3 3.744E-2
3.052E-1
 1 6
45 GO:0006824 cobalt ion transport 1.932E-3 6.635E-3 3.744E-2
3.052E-1
 1 6
46 GO:0035434 copper ion transmembrane transport 1.932E-3 6.635E-3 3.744E-2
3.052E-1
 1 6
47 GO:0034599 cellular response to oxidative stress 2.537E-3 8.137E-3 4.592E-2
4.009E-1
 2 247
48 GO:0034755 iron ion transmembrane transport 2.575E-3 8.137E-3 4.592E-2
4.069E-1
 1 8
49 GO:0071421 manganese ion transmembrane transport 2.575E-3 8.137E-3 4.592E-2
4.069E-1
 1 8
50 GO:0042421 norepinephrine biosynthetic process 2.575E-3 8.137E-3 4.592E-2
4.069E-1
 1 8
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 29 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070288 ferritin complex 8.258E-8 1.197E-6 4.743E-6 2.395E-6 2 2
2 GO:0008043 intracellular ferritin complex 8.258E-8 1.197E-6 4.743E-6 2.395E-6 2 2
3 GO:0070826 paraferritin complex 3.148E-4 3.043E-3 1.205E-2 9.129E-3 1 1
4 GO:0005759 mitochondrial matrix 7.011E-3 4.187E-2
1.659E-1
2.033E-1
 2 425
5 GO:0030904 retromer complex 7.219E-3 4.187E-2
1.659E-1
2.094E-1
 1 23

4: Human Phenotype [Display Chart] 5 input genes in category / 89 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011031 Abnormality of iron homeostasis 5.621E-6 4.651E-4 2.359E-3 5.003E-4 3 40
2 HP:0011030 Abnormality of transition element cation homeostasis 1.045E-5 4.651E-4 2.359E-3 9.302E-4 3 49
3 HP:0040133 Abnormal serum ferritin 4.997E-4 1.112E-2
5.638E-2
 4.447E-2 2 34
4 HP:0003281 Increased serum ferritin 4.997E-4 1.112E-2
5.638E-2
 4.447E-2 2 34
5 HP:0012343 Decreased serum ferritin 1.062E-3 1.351E-2
6.849E-2
9.454E-2
 1 1
6 HP:0012187 Increased erythrocyte protoporphyrin concentration 1.062E-3 1.351E-2
6.849E-2
9.454E-2
 1 1
7 HP:0007007 Cavitation of the basal ganglia 1.062E-3 1.351E-2
6.849E-2
9.454E-2
 1 1
8 HP:0010929 Abnormality of cation homeostasis 3.291E-3 3.661E-2
1.857E-1
2.929E-1
 3 338
9 HP:0003111 Abnormality of ion homeostasis 4.142E-3 4.096E-2
2.077E-1
3.687E-1
 3 366
Show 4 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 200 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001770 abnormal iron level 2.879E-9 3.539E-7 2.080E-6 5.758E-7 5 144
2 MP:0005637 abnormal iron homeostasis 3.539E-9 3.539E-7 2.080E-6 7.079E-7 5 150
3 MP:0008738 abnormal liver iron level 1.419E-6 9.460E-5 5.561E-4 2.838E-4 3 44
4 MP:0004152 abnormal circulating iron level 1.332E-5 6.658E-4 3.913E-3 2.663E-3 3 92
5 MP:0008743 decreased liver iron level 2.928E-5 1.171E-3 6.885E-3 5.856E-3 2 15
6 MP:0008808 decreased spleen iron level 3.791E-5 1.264E-3 7.427E-3 7.581E-3 2 17
7 MP:0008739 abnormal spleen iron level 1.291E-4 3.690E-3 2.169E-2 2.583E-2 2 31
8 MP:0008810 increased circulating iron level 3.523E-4 8.807E-3
5.177E-2
7.046E-2
 2 51
9 MP:0010376 decreased kidney iron level 5.794E-4 1.288E-2
7.569E-2
1.159E-1
 1 1
10 MP:0001577 anemia 8.753E-4 1.751E-2
1.029E-1
1.751E-1
 3 376
11 MP:0011091 prenatal lethality, complete penetrance 1.080E-3 1.931E-2
1.135E-1
2.159E-1
 3 404
12 MP:0020366 decreased brain iron level 1.159E-3 1.931E-2
1.135E-1
2.317E-1
 1 2
13 MP:0003131 increased erythrocyte cell number 1.377E-3 2.119E-2
1.246E-1
2.755E-1
 2 101
14 MP:0006357 abnormal circulating mineral level 1.815E-3 2.593E-2
1.524E-1
3.630E-1
 3 483
15 MP:0010021 heart vascular congestion 2.316E-3 2.895E-2
1.702E-1
4.632E-1
 1 4
16 MP:0020368 decreased heart iron level 2.316E-3 2.895E-2
1.702E-1
4.632E-1
 1 4
17 MP:0011288 decreased erythropoietin level 2.894E-3 3.047E-2
1.791E-1
5.789E-1
 1 5
18 MP:0011286 decreased circulating erythropoietin level 2.894E-3 3.047E-2
1.791E-1
5.789E-1
 1 5
19 MP:0002593 high mean erythrocyte cell number 2.894E-3 3.047E-2
1.791E-1
5.789E-1
 1 5
20 MP:0008811 abnormal brain iron level 3.472E-3 3.416E-2
2.008E-1
6.945E-1
 1 6
21 MP:0004952 increased spleen weight 3.587E-3 3.416E-2
2.008E-1
7.173E-1
 2 164
22 MP:0010034 abnormal erythrocyte clearance 4.050E-3 3.522E-2
2.070E-1
8.100E-1
 1 7
23 MP:0010035 increased erythrocyte clearance 4.050E-3 3.522E-2
2.070E-1
8.100E-1
 1 7
24 MP:0005664 decreased circulating noradrenaline level 4.628E-3 3.702E-2
2.176E-1
9.255E-1
 1 8
25 MP:0008956 decreased cellular hemoglobin content 4.628E-3 3.702E-2
2.176E-1
9.255E-1
 1 8
26 MP:0011188 increased erythrocyte protoporphyrin level 5.205E-3 3.730E-2
2.193E-1
1.000E0
 1 9
27 MP:0008741 abnormal heart iron level 5.205E-3 3.730E-2
2.193E-1
1.000E0
 1 9
28 MP:0000208 decreased hematocrit 5.342E-3 3.730E-2
2.193E-1
1.000E0
 2 201
29 MP:0002874 decreased hemoglobin content 5.552E-3 3.730E-2
2.193E-1
1.000E0
 2 205
30 MP:0008954 abnormal cellular hemoglobin content 5.782E-3 3.730E-2
2.193E-1
1.000E0
 1 10
31 MP:0011890 increased circulating ferritin level 5.782E-3 3.730E-2
2.193E-1
1.000E0
 1 10
32 MP:0003717 pallor 6.771E-3 4.079E-2
2.398E-1
1.000E0
 2 227
33 MP:0010811 decreased type II pneumocyte number 6.935E-3 4.079E-2
2.398E-1
1.000E0
 1 12
34 MP:0001396 unidirectional circling 6.935E-3 4.079E-2
2.398E-1
1.000E0
 1 12
35 MP:0010460 pulmonary artery hypoplasia 7.511E-3 4.260E-2
2.504E-1
1.000E0
 1 13
36 MP:0002875 decreased erythrocyte cell number 7.668E-3 4.260E-2
2.504E-1
1.000E0
 2 242
37 MP:0011889 abnormal circulating ferritin level 8.087E-3 4.371E-2
2.569E-1
1.000E0
 1 14
38 MP:0004951 abnormal spleen weight 8.359E-3 4.399E-2
2.586E-1
1.000E0
 2 253
39 MP:0008941 reticulocytopenia 9.237E-3 4.567E-2
2.685E-1
1.000E0
 1 16
40 MP:0008742 abnormal kidney iron level 9.237E-3 4.567E-2
2.685E-1
1.000E0
 1 16
41 MP:0004147 increased porphyrin level 9.812E-3 4.567E-2
2.685E-1
1.000E0
 1 17
42 MP:0011989 abnormal porphyrin level 9.812E-3 4.567E-2
2.685E-1
1.000E0
 1 17
43 MP:0002596 abnormal hematocrit 9.891E-3 4.567E-2
2.685E-1
1.000E0
 2 276
44 MP:0011285 increased circulating erythropoietin level 1.039E-2 4.567E-2
2.685E-1
1.000E0
 1 18
45 MP:0011287 increased erythropoietin level 1.039E-2 4.567E-2
2.685E-1
1.000E0
 1 18
46 MP:0005563 abnormal hemoglobin content 1.074E-2 4.567E-2
2.685E-1
1.000E0
 2 288
47 MP:0011283 abnormal erythropoietin level 1.096E-2 4.567E-2
2.685E-1
1.000E0
 1 19
48 MP:0011284 abnormal circulating erythropoietin level 1.096E-2 4.567E-2
2.685E-1
1.000E0
 1 19
49 MP:0013663 increased myeloid cell number 1.199E-2 4.844E-2
2.847E-1
1.000E0
 2 305
50 MP:0005663 abnormal circulating noradrenaline level 1.211E-2 4.844E-2
2.847E-1
1.000E0
 1 21
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 45 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF09029 Preseq ALAS Pfam 8.547E-8 1.282E-6 5.635E-6 3.846E-6 2 2
2 IPR010961 4pyrrol synth NH2levulA synth InterPro 8.547E-8 1.282E-6 5.635E-6 3.846E-6 2 2
3 IPR015118 5aminolev synth preseq InterPro 8.547E-8 1.282E-6 5.635E-6 3.846E-6 2 2
4 IPR014034 Ferritin CS InterPro 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
5 IPR009040 Ferritin-like diiron InterPro 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
6 PS00204 FERRITIN 2 PROSITE 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
7 PF00210 Ferritin Pfam 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
8 IPR008331 Ferritin DPS dom InterPro 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
9 PS00540 FERRITIN 1 PROSITE 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
10 PS50905 FERRITIN LIKE PROSITE 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
11 IPR001519 Ferritin InterPro 5.127E-7 2.097E-6 9.218E-6 2.307E-5 2 4
12 1.20.1260.10 - Gene3D 8.544E-7 3.204E-6 1.408E-5 3.845E-5 2 5
13 IPR001917 Aminotrans II pyridoxalP BS InterPro 1.281E-6 3.844E-6 1.689E-5 5.766E-5 2 6
14 IPR012347 Ferritin-rel InterPro 1.281E-6 3.844E-6 1.689E-5 5.766E-5 2 6
15 PS00599 AA TRANSFER CLASS 2 PROSITE 1.281E-6 3.844E-6 1.689E-5 5.766E-5 2 6
16 IPR009078 Ferritin-like SF InterPro 7.765E-6 2.184E-5 9.598E-5 3.494E-4 2 14
17 IPR004839 Aminotransferase I/II InterPro 1.160E-5 2.900E-5 1.275E-4 5.220E-4 2 17
18 PF00155 Aminotran 1 2 Pfam 1.160E-5 2.900E-5 1.275E-4 5.220E-4 2 17
19 3.90.1150.10 - Gene3D 5.359E-5 1.269E-4 5.578E-4 2.411E-3 2 36
20 IPR015422 PyrdxlP-dep Trfase major sub2 InterPro 5.664E-5 1.274E-4 5.601E-4 2.549E-3 2 37
21 3.40.640.10 - Gene3D 6.631E-5 1.421E-4 6.245E-4 2.984E-3 2 40
22 IPR015421 PyrdxlP-dep Trfase major sub1 InterPro 7.318E-5 1.432E-4 6.292E-4 3.293E-3 2 42
23 IPR015424 PyrdxlP-dep Trfase InterPro 7.318E-5 1.432E-4 6.292E-4 3.293E-3 2 42
24 IPR001046 NRAMP fam InterPro 6.404E-4 1.067E-3 4.691E-3 2.882E-2 1 2
25 IPR014887 HIF-1 TAD C InterPro 6.404E-4 1.067E-3 4.691E-3 2.882E-2 1 2
26 PF01566 Nramp Pfam 6.404E-4 1.067E-3 4.691E-3 2.882E-2 1 2
27 PF08778 HIF-1a CTAD Pfam 6.404E-4 1.067E-3 4.691E-3 2.882E-2 1 2
28 IPR021537 HIF alpha subunit InterPro 9.605E-4 1.490E-3 6.550E-3 4.322E-2 1 3
29 PF11413 HIF-1 Pfam 9.605E-4 1.490E-3 6.550E-3 4.322E-2 1 3
30 IPR001067 Nuc translocat InterPro 2.560E-3 3.839E-3 1.687E-2
1.152E-1
 1 8
31 PF08447 PAS 3 Pfam 7.344E-3 9.828E-3 4.319E-2
3.305E-1
 1 23
32 IPR013655 PAS fold 3 InterPro 7.344E-3 9.828E-3 4.319E-2
3.305E-1
 1 23
33 IPR000700 PAS-assoc C InterPro 7.663E-3 9.828E-3 4.319E-2
3.448E-1
 1 24
34 IPR013767 PAS fold InterPro 7.981E-3 9.828E-3 4.319E-2
3.591E-1
 1 25
35 PF00989 PAS Pfam 7.981E-3 9.828E-3 4.319E-2
3.591E-1
 1 25
36 IPR001610 PAC InterPro 8.299E-3 9.828E-3 4.319E-2
3.735E-1
 1 26
37 SM00086 PAC SMART 8.299E-3 9.828E-3 4.319E-2
3.735E-1
 1 26
38 PS50113 PAC PROSITE 8.299E-3 9.828E-3 4.319E-2
3.735E-1
 1 26
39 SM00091 PAS SMART 1.021E-2 1.178E-2
5.176E-2
4.593E-1
 1 32
40 IPR000014 PAS InterPro 1.084E-2 1.190E-2
5.229E-2
4.878E-1
 1 34
41 PS50112 PAS PROSITE 1.084E-2 1.190E-2
5.229E-2
4.878E-1
 1 34
42 PF00010 HLH Pfam 3.534E-2 3.752E-2
1.649E-1
1.000E0
 1 112
43 SM00353 HLH SMART 3.689E-2 3.752E-2
1.649E-1
1.000E0
 1 117
44 PS50888 BHLH PROSITE 3.721E-2 3.752E-2
1.649E-1
1.000E0
 1 118
45 IPR011598 bHLH dom InterPro 3.752E-2 3.752E-2
1.649E-1
1.000E0
 1 119
Show 40 more annotations

7: Pathway [Display Chart] 6 input genes in category / 46 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1510435 Ferroptosis BioSystems: KEGG 6.104E-7 1.881E-5 8.306E-5 2.808E-5 3 40
2 1269948 Iron uptake and transport BioSystems: REACTOME 8.177E-7 1.881E-5 8.306E-5 3.761E-5 3 44
3 212237 Mineral absorption BioSystems: KEGG 1.284E-6 1.969E-5 8.696E-5 5.907E-5 3 51
4 142231 tetrapyrrole biosynthesis BioSystems: BIOCYC 1.934E-6 2.225E-5 9.825E-5 8.898E-5 2 5
5 545289 heme biosynthesis BioSystems: BIOCYC 5.413E-6 4.980E-5 2.199E-4 2.490E-4 2 8
6 PW:0000218 heme biosynthetic Pathway Ontology 6.958E-6 5.334E-5 2.356E-4 3.201E-4 2 9
7 1270187 Heme biosynthesis BioSystems: REACTOME 1.063E-5 6.982E-5 3.084E-4 4.888E-4 2 11
8 M19553 Hemoglobin's Chaperone MSigDB C2 BIOCARTA (v6.0) 1.506E-5 8.661E-5 3.825E-4 6.929E-4 2 13
9 PW:0000047 glycine, serine and threonine metabolic Pathway Ontology 1.757E-5 8.980E-5 3.966E-4 8.082E-4 2 14
10 1270186 Metabolism of porphyrins BioSystems: REACTOME 2.624E-5 1.207E-4 5.331E-4 1.207E-3 2 17
11 1269899 Scavenging by Class A Receptors BioSystems: REACTOME 4.048E-5 1.693E-4 7.477E-4 1.862E-3 2 21
12 137956 HIF-2-alpha transcription factor network BioSystems: Pathway Interaction Database 1.078E-4 4.134E-4 1.826E-3 4.961E-3 2 34
13 82949 Glycine, serine and threonine metabolism BioSystems: KEGG 1.498E-4 5.299E-4 2.340E-3 6.889E-3 2 40
14 83021 Porphyrin and chlorophyll metabolism BioSystems: KEGG 1.652E-4 5.429E-4 2.398E-3 7.601E-3 2 42
15 1269897 Binding and Uptake of Ligands by Scavenger Receptors BioSystems: REACTOME 2.253E-4 6.911E-4 3.052E-3 1.037E-2 2 49
16 1269882 Golgi Associated Vesicle Biogenesis BioSystems: REACTOME 3.053E-4 8.777E-4 3.877E-3 1.404E-2 2 57
17 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 5.010E-4 1.280E-3 5.655E-3 2.305E-2 2 73
18 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 5.010E-4 1.280E-3 5.655E-3 2.305E-2 2 73
19 1270417 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 1.445E-3 3.499E-3 1.545E-2
6.648E-2
 1 3
20 1383026 PTK6 Expression BioSystems: REACTOME 2.408E-3 5.538E-3 2.446E-2
1.108E-1
 1 5
21 1270419 Regulation of gene expression by Hypoxia-inducible Factor BioSystems: REACTOME 5.770E-3 1.264E-2
5.583E-2
2.654E-1
 1 12
22 SMP00024 Porphyrin Metabolism SMPDB 7.209E-3 1.507E-2
6.657E-2
3.316E-1
 1 15
23 MAP00260 Glycine serine and threonine metabolism MAP00260 Glycine serine and threonine metabolism GenMAPP 1.104E-2 2.206E-2
9.744E-2
5.076E-1
 1 23
24 1269930 Metal ion SLC transporters BioSystems: REACTOME 1.199E-2 2.206E-2
9.744E-2
5.516E-1
 1 25
25 SMP00004 Glycine, Serine and Threonine Metabolism SMPDB 1.199E-2 2.206E-2
9.744E-2
5.516E-1
 1 25
26 1270346 Transcriptional regulation of pluripotent stem cells BioSystems: REACTOME 1.723E-2 3.048E-2
1.346E-1
7.925E-1
 1 36
27 137911 FOXA2 and FOXA3 transcription factor networks BioSystems: Pathway Interaction Database 2.102E-2 3.410E-2
1.506E-1
9.670E-1
 1 44
28 1457780 Neutrophil degranulation BioSystems: REACTOME 2.103E-2 3.410E-2
1.506E-1
9.674E-1
 2 492
29 1268841 Transcriptional activation of mitochondrial biogenesis BioSystems: REACTOME 2.150E-2 3.410E-2
1.506E-1
9.888E-1
 1 45
30 1268839 Mitochondrial biogenesis BioSystems: REACTOME 2.575E-2 3.948E-2
1.744E-1
1.000E0
 1 54
31 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 2.905E-2 4.310E-2
1.904E-1
1.000E0
 1 61
32 137940 Signaling events mediated by VEGFR1 and VEGFR2 BioSystems: Pathway Interaction Database 2.999E-2 4.310E-2
1.904E-1
1.000E0
 1 63
33 83107 Renal cell carcinoma BioSystems: KEGG 3.093E-2 4.311E-2
1.904E-1
1.000E0
 1 65
34 1383025 Signaling by PTK6 BioSystems: REACTOME 3.233E-2 4.311E-2
1.904E-1
1.000E0
 1 68
35 1270418 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 3.280E-2 4.311E-2
1.904E-1
1.000E0
 1 69
36 1270415 Cellular response to hypoxia BioSystems: REACTOME 3.748E-2 4.660E-2
2.058E-1
1.000E0
 1 79
37 1270416 Regulation of Hypoxia-inducible Factor (HIF) by oxygen BioSystems: REACTOME 3.748E-2 4.660E-2
2.058E-1
1.000E0
 1 79
Show 32 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1374 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19596281 Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Pubmed 4.307E-11 5.918E-8 4.618E-7 5.918E-8 3 6
2 16787915 Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. Pubmed 1.205E-9 7.436E-7 5.803E-6 1.656E-6 3 16
3 22760008 The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
4 12387819 Active human ferritin H/L-hybrid and sequence effect on folding efficiency in Escherichia coli. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
5 18160403 Ferritin L and H subunits are differentially regulated on a post-transcriptional level. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
6 8630420 Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
7 2263504 Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
8 11566198 The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
9 14615048 Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
10 17970701 Analysis of ferritin genes in Parkinson disease. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
11 29046127 Serum ferritin is a different predictor from transfusion history for allogeneic transplantation outcome in patients with severe aplastic anemia. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
12 659425 On ferritin heterogeneity. Further evidence for heteropolymers. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
13 8969195 Role of H and L subunits in mouse ferritin. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
14 19917609 Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
15 28636371 Iron Oxidation and Core Formation in Recombinant Heteropolymeric Human Ferritins. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
16 20088381 [Expression of FTL and FTH genes encoding ferretin subunits in lung and renal carcinomas]. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
17 15727900 Intra-leukocytic hemosiderin inclusions detected as pseudoeosinophils by automated depolarization analysis in a patient with beta-thalassaemia major and immune hemolysis. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
18 20472835 Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
19 10652280 Early embryonic lethality of H ferritin gene deletion in mice. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
20 21029774 Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
21 2347585 Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
22 24282296 Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
23 26518749 The importance of eukaryotic ferritins in iron handling and cytoprotection. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
24 28349628 Ferritin, cellular iron storage and regulation. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
25 8892964 Expression of H and L ferritin mRNAs in mouse small intestine. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
26 22117997 Oxidative stress levels in myelodysplastic syndrome patients: their relationship to serum ferritin and haemoglobin values. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
27 3857215 Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
28 2780318 Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
29 2708374 Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
30 3023856 Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
31 6653779 The amino acid sequence of human liver apoferritin. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
32 25629408 Systemic and cerebral iron homeostasis in ferritin knock-out mice. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
33 8626471 Novel properties of L-type polypeptide subunits in mouse ferritin molecules. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
34 3858810 Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
35 27611581 Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
36 26602884 Ferritin is associated with neural differentiation of bone marrow-derived mesenchymal stem cells under extremely low-frequency electromagnetic field. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
37 24512320 Ferritin as prognostic marker in multiple myeloma patients undergoing autologous transplantation. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
38 2004762 Mouse ferritin H sequences map to chromosomes 3, 6, and 19. Pubmed 2.057E-8 7.436E-7 5.803E-6 2.826E-5 2 2
39 28289076 Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
40 16234850 Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
41 29729700 Fcγ receptor III expression and morphological maturity on neutrophil are associated with higher iron level of major beta-thalassemia. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
42 23119080 Hyperferritinemia and hyperuricemia may be associated with liver function abnormality in obese adolescents. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
43 18621011 Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
44 3840162 Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
45 17761032 The association of circulating ferritin with serum concentrations of fibroblast growth factor-23 measured by three commercial assays. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
46 7636015 Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
47 19120692 Haemopexin affects iron distribution and ferritin expression in mouse brain. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
48 8612737 A link between ferritin gene expression and ribonucleotide reductase R2 protein, as demonstrated by retroviral vector mediated stable expression of R2 cDNA. Pubmed 6.170E-8 1.766E-6 1.378E-5 8.477E-5 2 3
49 23892696 Iron and proinflammatory cytokines in chronic hepatitis C virus infection. Pubmed 1.234E-7 3.460E-6 2.700E-5 1.695E-4 2 4
50 17116749 Comparative proteomics of clathrin-coated vesicles. Pubmed 2.056E-7 5.651E-6 4.409E-5 2.825E-4 2 5
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 307 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NCOA4 NCOA4 interactions 4.727E-5 1.443E-2
9.100E-2
 1.451E-2 2 32
2 int:FTL FTL interactions 1.359E-4 1.443E-2
9.100E-2
 4.173E-2 2 54
3 int:PPL PPL interactions 1.410E-4 1.443E-2
9.100E-2
 4.330E-2 2 55
4 int:KPNA3 KPNA3 interactions 4.040E-4 2.312E-2
1.458E-1
1.240E-1
 2 93
5 int:SPP1 SPP1 interactions 4.304E-4 2.312E-2
1.458E-1
1.321E-1
 2 96
6 int:FTH1 FTH1 interactions 4.669E-4 2.312E-2
1.458E-1
1.433E-1
 2 100
7 int:CEP57 CEP57 interactions 6.276E-4 2.312E-2
1.458E-1
1.927E-1
 2 116
8 int:IGDCC3 IGDCC3 interactions 6.778E-4 2.312E-2
1.458E-1
2.081E-1
 1 2
9 int:TMSB4XP2 TMSB4XP2 interactions 6.778E-4 2.312E-2
1.458E-1
2.081E-1
 1 2
10 int:TMSB4XP1 TMSB4XP1 interactions 1.016E-3 3.121E-2
1.968E-1
3.121E-1
 1 3
11 int:C2orf42 C2orf42 interactions 1.355E-3 3.375E-2
2.128E-1
4.160E-1
 1 4
12 int:TMSB4XP6 TMSB4XP6 interactions 1.355E-3 3.375E-2
2.128E-1
4.160E-1
 1 4
13 int:MAX MAX interactions 1.551E-3 3.375E-2
2.128E-1
4.762E-1
 2 183
14 int:LUC7L2 LUC7L2 interactions 1.619E-3 3.375E-2
2.128E-1
4.970E-1
 2 187
15 int:ALAS2 ALAS2 interactions 1.694E-3 3.375E-2
2.128E-1
5.200E-1
 1 5
16 int:IGSF8 IGSF8 interactions 1.759E-3 3.375E-2
2.128E-1
5.399E-1
 2 195
17 int:KLHL35 KLHL35 interactions 2.032E-3 3.444E-2
2.172E-1
6.239E-1
 1 6
18 int:SDR16C5 SDR16C5 interactions 2.032E-3 3.444E-2
2.172E-1
6.239E-1
 1 6
19 int:SDCBP SDCBP interactions 2.312E-3 3.444E-2
2.172E-1
7.098E-1
 2 224
20 int:UCHL5 UCHL5 interactions 2.333E-3 3.444E-2
2.172E-1
7.161E-1
 2 225
21 int:RTL8B RTL8B interactions 2.709E-3 3.444E-2
2.172E-1
8.316E-1
 1 8
22 int:SLC11A2 SLC11A2 interactions 2.709E-3 3.444E-2
2.172E-1
8.316E-1
 1 8
23 int:ZNF175 ZNF175 interactions 3.047E-3 3.444E-2
2.172E-1
9.354E-1
 1 9
24 int:NR3C1 NR3C1 interactions 3.290E-3 3.444E-2
2.172E-1
1.000E0
 2 268
25 int:ZMAT1 ZMAT1 interactions 3.385E-3 3.444E-2
2.172E-1
1.000E0
 1 10
26 int:ZNF558 ZNF558 interactions 3.385E-3 3.444E-2
2.172E-1
1.000E0
 1 10
27 int:IL1RN IL1RN interactions 3.723E-3 3.444E-2
2.172E-1
1.000E0
 1 11
28 int:HERC2 HERC2 interactions 3.841E-3 3.444E-2
2.172E-1
1.000E0
 2 290
29 int:IL37 IL37 interactions 4.061E-3 3.444E-2
2.172E-1
1.000E0
 1 12
30 int:TREX2 TREX2 interactions 4.061E-3 3.444E-2
2.172E-1
1.000E0
 1 12
31 int:MYL3 MYL3 interactions 4.061E-3 3.444E-2
2.172E-1
1.000E0
 1 12
32 int:HIF3A HIF3A interactions 4.061E-3 3.444E-2
2.172E-1
1.000E0
 1 12
33 int:SERPINB7 SERPINB7 interactions 4.399E-3 3.444E-2
2.172E-1
1.000E0
 1 13
34 int:TGM5 TGM5 interactions 4.399E-3 3.444E-2
2.172E-1
1.000E0
 1 13
35 int:ECHDC2 ECHDC2 interactions 5.074E-3 3.444E-2
2.172E-1
1.000E0
 1 15
36 int:PLBD1 PLBD1 interactions 5.074E-3 3.444E-2
2.172E-1
1.000E0
 1 15
37 int:TMSB10 TMSB10 interactions 5.411E-3 3.444E-2
2.172E-1
1.000E0
 1 16
38 int:RBP4 RBP4 interactions 5.411E-3 3.444E-2
2.172E-1
1.000E0
 1 16
39 int:CAPNS2 CAPNS2 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
40 int:SPINK7 SPINK7 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
41 int:KLK10 KLK10 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
42 int:SNX20 SNX20 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
43 int:MTFR2 MTFR2 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
44 int:THEM4 THEM4 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
45 int:CD99 CD99 interactions 5.749E-3 3.444E-2
2.172E-1
1.000E0
 1 17
46 int:VHL VHL interactions 5.892E-3 3.444E-2
2.172E-1
1.000E0
 2 361
47 int:DBP DBP interactions 6.086E-3 3.444E-2
2.172E-1
1.000E0
 1 18
48 int:ELL3 ELL3 interactions 6.086E-3 3.444E-2
2.172E-1
1.000E0
 1 18
49 int:BATF2 BATF2 interactions 6.086E-3 3.444E-2
2.172E-1
1.000E0
 1 18
50 int:AURKA AURKA interactions 6.214E-3 3.444E-2
2.172E-1
1.000E0
 2 371
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2p21-p16 2p21-p16 6.923E-4 4.154E-3 1.018E-2 4.154E-3 1 4
2 Xp11.21 Xp11.21 6.044E-3 1.553E-2 3.805E-2 3.626E-2 1 35
3 3p21.1 3p21.1 7.765E-3 1.553E-2 3.805E-2 4.659E-2 1 45
4 12q13 12q13 1.223E-2 1.834E-2 4.494E-2
7.337E-2
 1 71
5 19q13.33 19q13.33 1.855E-2 2.042E-2
5.004E-2
1.113E-1
 1 108
6 11q13 11q13 2.042E-2 2.042E-2
5.004E-2
1.225E-1
 1 119
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 15 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 420 Basic helix-loop-helix proteins genenames.org 1.206E-2 2.411E-2 3.617E-2 2.411E-2 1 110
2 752 Solute carriers genenames.org 4.295E-2 4.295E-2
6.443E-2
8.590E-2
 1 395

13: Coexpression [Display Chart] 6 input genes in category / 1032 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19489030-SuppTable4 Human Prostate Chambers09 196genes GeneSigDB 4.561E-6 2.666E-3 2.004E-2 4.707E-3 3 143
2 16310191-Table2 Human Leukemia Gonzalez05 25genes GeneSigDB 9.565E-6 2.666E-3 2.004E-2 9.871E-3 2 19
3 M4606 Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v6.0) 1.230E-5 2.666E-3 2.004E-2 1.269E-2 3 199
4 M4492 Genes down-regulated in comparison of naive CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 1.248E-5 2.666E-3 2.004E-2 1.288E-2 3 200
5 M1407 Genes up-regulated after GATA1 [GeneID=2623] activation in G1E-ER4 cells (erythroid precursors engineered to express GATA1 upon addition of estradiol [PubChem=5757]). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.292E-5 2.666E-3 2.004E-2 1.333E-2 2 22
6 16140920-Table1b Human Brain Natsume05 54genes GeneSigDB 2.268E-5 3.901E-3 2.933E-2 2.341E-2 2 29
7 19489030-SuppTable5 Human Prostate Chambers09 47genes GeneSigDB 3.322E-5 4.537E-3 3.410E-2 3.428E-2 2 35
8 M6891 Genes known to modulate ROS or whose expression changes in response to ROS MSigDB C2: CGP Curated Gene Sets (v6.0) 3.517E-5 4.537E-3 3.410E-2 3.629E-2 2 36
9 M854 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.470E-5 6.121E-3 4.601E-2
5.645E-2
 3 328
10 M12636 Genes up-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.982E-5 6.121E-3 4.601E-2
6.173E-2
 3 338
11 19096012-TableS3 Human Viral Chetaille09 425genes GeneSigDB 6.524E-5 6.121E-3 4.601E-2
6.733E-2
 3 348
12 M2567 Genes down-regulated in T98 cells (glioma) 48 h after treatment with interferon beta. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.389E-5 6.354E-3 4.776E-2
7.625E-2
 2 52
13 M19971 Genes up-regulated in peripheral blood mononucleocytes by HGF [GeneID=3082] compared to those regulated by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.047E-4 7.244E-3
5.445E-2
1.080E-1
 3 408
14 12176889-Table1 Human Lung Dekker02 68genes GeneSigDB 1.052E-4 7.244E-3
5.445E-2
1.086E-1
 2 62
15 M18149 Genes up-regulated in peripheral blood monocytes by HGF [GeneID=3082]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.124E-4 7.244E-3
5.445E-2
1.160E-1
 3 418
16 M11720 Genes down-regulated in cancer stem cells derived from glyoblastoma tumors: CD133+ [GeneID=8842] vs. CD133- cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.193E-4 7.244E-3
5.445E-2
1.231E-1
 2 66
17 16533762-Table1 Human Uterine Matsumura06 67genes GeneSigDB 1.193E-4 7.244E-3
5.445E-2
1.231E-1
 2 66
18 M10508 Genes known to be induced by hypoxia MSigDB C2: CGP Curated Gene Sets (v6.0) 1.799E-4 1.032E-2
7.755E-2
1.857E-1
 2 81
19 17483311-SuppTable3 Human Brain Beier07 117genes GeneSigDB 2.688E-4 1.460E-2
1.098E-1
2.774E-1
 2 99
20 15976005-Table2 Human Breast Graham05 133genes GeneSigDB 3.199E-4 1.480E-2
1.113E-1
3.301E-1
 2 108
21 M2392 Genes up-regulated in 745A cells (erythroleukemia) upon knockdown of FLI1 [GeneID=2313] by RNAi and down-regulation of SPI1 [GeneID=6688] by HMBA [PubChem=3616]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.626E-4 1.480E-2
1.113E-1
3.742E-1
 2 115
22 M9016 Genes down-regulated in polysomal and total RNA samples from SW480 cells (primary colorectal carcinoma, CRC) compared to the SW620 cells (lymph node metastasis from the same individual). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.066E-4 1.480E-2
1.113E-1
5.228E-1
 2 136
23 15812645-Table2c Mouse Thymus Stremmel05 2genes GeneSigDB 5.186E-4 1.480E-2
1.113E-1
5.352E-1
 1 2
24 14767473-Table3 Human Pancreas Nakamura04 168genes GeneSigDB 6.239E-4 1.480E-2
1.113E-1
6.438E-1
 2 151
25 15980968-Table3b Human Brain Bandres05 182genes GeneSigDB 6.488E-4 1.480E-2
1.113E-1
6.695E-1
 2 154
26 16081686-SuppTable2 Human Lymphoma Tome05 357genes GeneSigDB 6.572E-4 1.480E-2
1.113E-1
6.782E-1
 2 155
27 M9556 Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.087E-4 1.480E-2
1.113E-1
7.314E-1
 2 161
28 M6701 Genes down-regulated in endothelial cells: interferon alpha versus interferon beta. MSigDB C7: Immunologic Signatures (v6.0) 7.352E-4 1.480E-2
1.113E-1
7.587E-1
 2 164
29 M12498 Molecular timetable composed of 162 time-indicating genes (182 probes) in the peripheral (liver) clock. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.804E-4 1.480E-2
1.113E-1
8.054E-1
 2 169
30 M2980 Genes down-regulated in B lymphocytes: control versus stimulated by anti-IgM for 12h. MSigDB C7: Immunologic Signatures (v6.0) 7.896E-4 1.480E-2
1.113E-1
8.149E-1
 2 170
31 M7625 Genes up-regulated in memory CD8 T cells: 1' versus 4'. MSigDB C7: Immunologic Signatures (v6.0) 8.269E-4 1.480E-2
1.113E-1
8.534E-1
 2 174
32 M7624 Genes up-regulated in memory CD8 T cells: 2' versus 4'. MSigDB C7: Immunologic Signatures (v6.0) 8.459E-4 1.480E-2
1.113E-1
8.730E-1
 2 176
33 M8898 Genes down-regulated in CD4 [GeneID=920] versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 8.651E-4 1.480E-2
1.113E-1
8.928E-1
 2 178
34 M2946 Genes down-regulated in induced T reg: wildtype versus non-functional FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 9.041E-4 1.480E-2
1.113E-1
9.330E-1
 2 182
35 M2630 Genes down-regulated in mouse fibroblasts over-expressing E2F1 [Gene ID=1869] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.005E-3 1.480E-2
1.113E-1
1.000E0
 2 192
36 M2634 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] and engineered to express ligand-activatable EGFR [Gene ID=1956]. MSigDB C6: Oncogenic Signatures (v6.0) 1.016E-3 1.480E-2
1.113E-1
1.000E0
 2 193
37 M2728 Genes up-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.026E-3 1.480E-2
1.113E-1
1.000E0
 2 194
38 M3114 Genes down-regulated in comarison of effector memory T cells versus peripheral blood mononuclear cells (PBMC). MSigDB C7: Immunologic Signatures (v6.0) 1.069E-3 1.480E-2
1.113E-1
1.000E0
 2 198
39 M8672 Genes up-regulated in monocytes (6h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.480E-2
1.113E-1
1.000E0
 2 199
40 M3028 Genes down-regulated in comparison of naive versus memory CD8 T cells (day 40+ following LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.480E-2
1.113E-1
1.000E0
 2 199
41 M3110 Genes down-regulated in comparison of naive T cells versus peripheral blood mononuclear cells (PBMC). MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.480E-2
1.113E-1
1.000E0
 2 199
42 M8356 Genes down-regulated in atherosclerosis macrophages: control anti miR ctrl versus untreated. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 1.480E-2
1.113E-1
1.000E0
 2 199
43 M4476 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
44 M5945 Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation. MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
45 M5726 Genes down-regulated in comparison of NK cells treated with IL15 [GeneID=3567] versus total splenocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
46 M3032 Genes down-regulated in comparison of effector CD8 T cells at the peak expansion phase (day8) versus those at contraction (day 15) after LCMV-Armstrong infection in mice. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
47 M3132 Genes down-regulated in comparison of untreated macrophages versus those cultured with M-CSF [GeneID=1435], IFNG [GeneID=3458] and Pam3Cys (TLR2 agonist). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
48 M3425 Genes up-regulated in comparison of control CD4 [GeneID=920] CD8 thymocytes versus those after stimulation with anti-Valpha2 antibodies. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
49 M8367 Genes down-regulated in T reg from: peripheral blood versus cord blood. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
50 M3264 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) cultured for 0 h versus PBMC cultured for 12 h with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 1.480E-2
1.113E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 1260 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F8 Adult, Development, and Cancer types 1.889E-7 2.380E-4 1.836E-3 2.380E-4 2 3
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour VHL RCC R U/Kidney Tumour VHL RCC R21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour VHL RCC R U/Kidney Tumour VHL RCC R21 Adult, Development, and Cancer types 1.762E-6 1.110E-3 8.564E-3 2.220E-3 2 8
3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC Adult, Development, and Cancer types 2.830E-6 1.188E-3 9.168E-3 3.566E-3 2 10
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP/Kidney Normal-Cortex Wilms MNP Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP/Kidney Normal-Cortex Wilms MNP Adult, Development, and Cancer types 4.904E-6 1.188E-3 9.168E-3 6.180E-3 2 13
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour RCC Endothelium/Kidney Tumour RCC T11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour RCC Endothelium/Kidney Tumour RCC T11 Adult, Development, and Cancer types 5.721E-6 1.188E-3 9.168E-3 7.209E-3 2 14
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal-Cortex post-natal kidney Normal cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Normal cell/Kidney Normal-Cortex post-natal kidney Normal cell Adult, Development, and Cancer types 6.600E-6 1.188E-3 9.168E-3 8.317E-3 2 15
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal-Cortex post-natal kidney Junk Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal-Cortex post-natal kidney Junk Adult, Development, and Cancer types 6.600E-6 1.188E-3 9.168E-3 8.317E-3 2 15
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT4 Adult, Development, and Cancer types 9.614E-6 1.514E-3 1.168E-2 1.211E-2 2 18
9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour RCC R U/Kidney Tumour RCC R11 Adult, Development, and Cancer types 1.451E-5 1.783E-3 1.376E-2 1.828E-2 2 22
10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell/Kidney Normal-Cortex Wilms NK3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell/Kidney Normal-Cortex Wilms NK3 Adult, Development, and Cancer types 1.589E-5 1.783E-3 1.376E-2 2.002E-2 2 23
11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U/Kidney Normal-Cortex Wilms R3 Adult, Development, and Cancer types 1.589E-5 1.783E-3 1.376E-2 2.002E-2 2 23
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex Wilms NK cell Adult, Development, and Cancer types 1.884E-5 1.783E-3 1.376E-2 2.373E-2 2 25
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex post-natal kidney Ureter epithelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex post-natal kidney Ureter epithelium Adult, Development, and Cancer types 1.884E-5 1.783E-3 1.376E-2 2.373E-2 2 25
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Normal-Cortex post-natal kidney Th cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Normal-Cortex post-natal kidney Th cell Adult, Development, and Cancer types 2.040E-5 1.783E-3 1.376E-2 2.571E-2 2 26
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour RCC NK cell/Kidney Tumour RCC NK11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour RCC NK cell/Kidney Tumour RCC NK11 Adult, Development, and Cancer types 2.372E-5 1.783E-3 1.376E-2 2.989E-2 2 28
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-C/Ureter Normal RCC EN-C/Ureter Normal RCC EN1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-C/Ureter Normal RCC EN-C/Ureter Normal RCC EN1 Adult, Development, and Cancer types 2.372E-5 1.783E-3 1.376E-2 2.989E-2 2 28
17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex Wilms R U Adult, Development, and Cancer types 2.548E-5 1.783E-3 1.376E-2 3.210E-2 2 29
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour VHL RCC NK cell/Kidney Tumour VHL RCC NK5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour VHL RCC NK cell/Kidney Tumour VHL RCC NK5 Adult, Development, and Cancer types 2.548E-5 1.783E-3 1.376E-2 3.210E-2 2 29
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium Adult, Development, and Cancer types 3.312E-5 2.086E-3 1.610E-2 4.173E-2 2 33
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal-Cortex Wilms CD8 T cell/Kidney Normal-Cortex Wilms IT3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal-Cortex Wilms CD8 T cell/Kidney Normal-Cortex Wilms IT3 Adult, Development, and Cancer types 3.312E-5 2.086E-3 1.610E-2 4.173E-2 2 33
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Normal Wilms EN-G Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Normal Wilms EN-G Adult, Development, and Cancer types 3.518E-5 2.111E-3 1.629E-2 4.433E-2 2 34
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N14 Adult, Development, and Cancer types 3.731E-5 2.137E-3 1.649E-2 4.701E-2 2 35
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Cortex post-natal kidney Nephrogenesis Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Cortex post-natal kidney Nephrogenesis Adult, Development, and Cancer types 4.644E-5 2.544E-3 1.963E-2
5.852E-2
 2 39
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal-Cortex Wilms Junk Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal-Cortex Wilms Junk Adult, Development, and Cancer types 4.888E-5 2.566E-3 1.980E-2
6.159E-2
 2 40
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour RCC Nephron epithelium/Kidney Tumour RCC N11 Adult, Development, and Cancer types 5.395E-5 2.614E-3 2.017E-2
6.797E-2
 2 42
26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Tumour RCC EN-B/Kidney Tumour RCC EN11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Tumour RCC EN-B/Kidney Tumour RCC EN11 Adult, Development, and Cancer types 5.395E-5 2.614E-3 2.017E-2
6.797E-2
 2 42
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour Wilms R U/Kidney Tumour Wilms R4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour Wilms R U/Kidney Tumour Wilms R4 Adult, Development, and Cancer types 5.926E-5 2.765E-3 2.134E-2
7.466E-2
 2 44
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U7 Adult, Development, and Cancer types 6.769E-5 3.019E-3 2.330E-2
8.529E-2
 2 47
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Cortex post-natal kidney Renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Cortex post-natal kidney Renal cell carcinoma Adult, Development, and Cancer types 7.362E-5 3.019E-3 2.330E-2
9.276E-2
 2 49
30 Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C6-KC3 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Stroma Stroma Subtype E14-Six2TGC-Stroma2-C6-KC3 Top 200 Genes 7.491E-5 3.019E-3 2.330E-2
9.438E-2
 3 344
31 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex Wilms Endothelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex Wilms Endothelium Adult, Development, and Cancer types 7.668E-5 3.019E-3 2.330E-2
9.661E-2
 2 50
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Normal RCC EN-U/Kidney Normal RCC EN15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney Normal RCC EN-U/Kidney Normal RCC EN15 Adult, Development, and Cancer types 7.668E-5 3.019E-3 2.330E-2
9.661E-2
 2 50
33 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Cortex Wilms PT-U/Kidney Normal-Cortex Wilms PT7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal-Cortex Wilms PT-U/Kidney Normal-Cortex Wilms PT7 Adult, Development, and Cancer types 7.980E-5 3.047E-3 2.351E-2
1.005E-1
 2 51
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex post-natal kidney Endothelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex post-natal kidney Endothelium Adult, Development, and Cancer types 9.632E-5 3.570E-3 2.754E-2
1.214E-1
 2 56
35 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal VHL RCC U U/Kidney Normal VHL RCC U6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal VHL RCC U U/Kidney Normal VHL RCC U6 Adult, Development, and Cancer types 1.220E-4 4.394E-3 3.390E-2
1.538E-1
 2 63
36 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium Adult, Development, and Cancer types 1.381E-4 4.834E-3 3.730E-2
1.740E-1
 2 67
37 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal-Cortex Wilms CD8 T cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney Normal-Cortex Wilms CD8 T cell Adult, Development, and Cancer types 1.640E-4 5.439E-3 4.197E-2
2.067E-1
 2 73
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium/Kidney Normal-Cortex Wilms U3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium/Kidney Normal-Cortex Wilms U3 Adult, Development, and Cancer types 1.640E-4 5.439E-3 4.197E-2
2.067E-1
 2 73
39 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour VHL RCC PT-U/Kidney Tumour VHL RCC PT17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour VHL RCC PT-U/Kidney Tumour VHL RCC PT17 Adult, Development, and Cancer types 1.686E-4 5.446E-3 4.202E-2
2.124E-1
 2 74
40 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC/Kidney Normal-Cortex post-natal kidney MNP PapRCC Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP PapRCC/Kidney Normal-Cortex post-natal kidney MNP PapRCC Adult, Development, and Cancer types 1.778E-4 5.601E-3 4.322E-2
2.241E-1
 2 76
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal-Medulla post-natal kidney EN-A/Kidney Normal-Medulla post-natal kidney EN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal-Medulla post-natal kidney EN-A/Kidney Normal-Medulla post-natal kidney EN4 Adult, Development, and Cancer types 1.922E-4 5.898E-3 4.551E-2
2.421E-1
 2 79
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK4 Adult, Development, and Cancer types 2.121E-4 5.898E-3 4.551E-2
2.673E-1
 2 83
43 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Tumour PapRCC Junk/Kidney Tumour PapRCC IF4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Tumour PapRCC Junk/Kidney Tumour PapRCC IF4 Adult, Development, and Cancer types 2.173E-4 5.898E-3 4.551E-2
2.738E-1
 2 84
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal-Cortex Wilms Junk/Kidney Normal-Cortex Wilms IN3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Normal-Cortex Wilms Junk/Kidney Normal-Cortex Wilms IN3 Adult, Development, and Cancer types 2.173E-4 5.898E-3 4.551E-2
2.738E-1
 2 84
45 gudmap dev gonad e13.5 M gudmap devVasTestis Flk 100 dev gonad e13.5 M DevVasTestis Flk top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.173E-4 5.898E-3 4.551E-2
2.738E-1
 2 84
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal Wilms EN-A/Kidney Normal Wilms EN7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal Wilms EN-A/Kidney Normal Wilms EN7 Adult, Development, and Cancer types 2.225E-4 5.898E-3 4.551E-2
2.804E-1
 2 85
47 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/leukocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Lung/leukocyte Tabula Muris Consortium 2.439E-4 5.898E-3 4.551E-2
3.074E-1
 2 89
48 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour PapRCC Th cell/Kidney Tumour PapRCC IN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour PapRCC Th cell/Kidney Tumour PapRCC IN4 Adult, Development, and Cancer types 2.495E-4 5.898E-3 4.551E-2
3.143E-1
 2 90
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R4 Adult, Development, and Cancer types 2.721E-4 5.898E-3 4.551E-2
3.429E-1
 2 94
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal VHL RCC MNP1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal VHL RCC MNP1 Adult, Development, and Cancer types 2.749E-4 5.898E-3 4.551E-2
3.463E-1
 1 1
Show 45 more annotations

15: Computational [Display Chart] 6 input genes in category / 60 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11185 MODULE 128 Genes in the cancer module 128. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.380E-3 2.122E-2
9.929E-2
8.279E-2
 2 98
2 M8286 MODULE 79 Genes in the cancer module 79. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.436E-3 2.122E-2
9.929E-2
8.617E-2
 2 100
3 M2944 MODULE 170 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.465E-3 2.122E-2
9.929E-2
8.789E-2
 2 101
4 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.649E-3 2.122E-2
9.929E-2
9.895E-2
 3 453
5 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.768E-3 2.122E-2
9.929E-2
1.061E-1
 3 464
6 M15748 MODULE 540 Iron ion homeostasis. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.964E-3 4.240E-2
1.984E-1
3.579E-1
 1 10
7 M443 MODULE 377 Energy pathways and carbohydrate metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.559E-3 4.240E-2
1.984E-1
3.936E-1
 1 11
8 M1136 MODULE 335 Genes in the cancer module 335. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.342E-3 4.240E-2
1.984E-1
5.005E-1
 1 14
9 M586 MODULE 227 Genes in the cancer module 227. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.936E-3 4.240E-2
1.984E-1
5.361E-1
 1 15
10 M9798 MODULE 14 Genes in the cancer module 13. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.936E-3 4.240E-2
1.984E-1
5.361E-1
 1 15
11 M17504 MODULE 539 Genes in the cancer module 539. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.529E-3 4.240E-2
1.984E-1
5.717E-1
 1 16
12 M10264 MODULE 516 Genes in the cancer module 516. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.529E-3 4.240E-2
1.984E-1
5.717E-1
 1 16
13 M17345 MODULE 178 Genes in the cancer module 178. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.012E-2 4.240E-2
1.984E-1
6.073E-1
 1 17
14 M575 MODULE 444 Genes in the cancer module 444. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.071E-2 4.240E-2
1.984E-1
6.429E-1
 1 18
15 M3341 MODULE 311 Genes in the cancer module 311. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.071E-2 4.240E-2
1.984E-1
6.429E-1
 1 18
16 M17192 MODULE 191 Genes in the cancer module 191. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.131E-2 4.240E-2
1.984E-1
6.784E-1
 1 19
17 M7112 MODULE 362 Angiogenesis. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.249E-2 4.252E-2
1.990E-1
7.495E-1
 1 21
18 M4582 MODULE 249 Genes in the cancer module 249. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.308E-2 4.252E-2
1.990E-1
7.850E-1
 1 22
19 M2667 MODULE 19 Adrenal gland - metabolic genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.346E-2 4.252E-2
1.990E-1
8.078E-1
 2 314
20 M2027 MODULE 212 Catalytic activities / metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.472E-2 4.417E-2
2.067E-1
8.834E-1
 2 329
21 M18929 MODULE 12 Spinal cord (neuro-development) genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.749E-2 4.996E-2
2.338E-1
1.000E0
 2 360
Show 16 more annotations

16: MicroRNA [Display Chart] 6 input genes in category / 188 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-423-3p:Functional MTI Functional MTI miRTarbase 1.501E-4 1.734E-2
1.008E-1
 2.822E-2 2 230
2 hsa-miR-6771-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.844E-4 1.734E-2
1.008E-1
 3.467E-2 2 255
3 hsa-miR-1537-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.411E-3 3.917E-2
2.278E-1
2.653E-1
 1 17
4 hsa-miR-4655-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.075E-3 3.917E-2
2.278E-1
3.900E-1
 1 25
5 hsa-miR-6763-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.323E-3 3.917E-2
2.278E-1
4.368E-1
 1 28
6 hsa-miR-5579-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.566E-3 3.917E-2
2.278E-1
6.704E-1
 1 43
7 TCTGATC,MIR-383:MSigDB TCTGATC,MIR-383:MSigDB MSigDB 3.897E-3 3.917E-2
2.278E-1
7.327E-1
 1 47
8 hsa-miR-550a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.063E-3 3.917E-2
2.278E-1
7.638E-1
 1 49
9 hsa-miR-200c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 3.917E-2
2.278E-1
7.794E-1
 1 50
10 hsa-miR-3667-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 3.917E-2
2.278E-1
8.261E-1
 1 53
11 hsa-miR-941:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 3.917E-2
2.278E-1
8.572E-1
 1 55
12 hsa-miR-4758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 3.917E-2
2.278E-1
1.000E0
 1 65
13 hsa-miR-6126:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.917E-2
2.278E-1
1.000E0
 1 70
14 hsa-miR-548ba:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.917E-2
2.278E-1
1.000E0
 1 70
15 hsa-miR-548ai:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.883E-3 3.917E-2
2.278E-1
1.000E0
 1 71
16 hsa-miR-570-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.917E-2
2.278E-1
1.000E0
 1 72
17 hsa-miR-4725-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.917E-2
2.278E-1
1.000E0
 1 73
18 hsa-miR-548ag:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 3.917E-2
2.278E-1
1.000E0
 1 73
19 hsa-miR-7108-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.461E-3 3.917E-2
2.278E-1
1.000E0
 1 78
20 hsa-miR-6864-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.461E-3 3.917E-2
2.278E-1
1.000E0
 1 78
21 hsa-miR-6889-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 3.917E-2
2.278E-1
1.000E0
 1 83
22 hsa-miR-6777-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 3.917E-2
2.278E-1
1.000E0
 1 83
23 hsa-miR-4790-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.917E-2
2.278E-1
1.000E0
 1 84
24 hsa-miR-4511:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 3.917E-2
2.278E-1
1.000E0
 1 84
25 hsa-miR-1225-5p:PITA hsa-miR-1225-5p:PITA TOP PITA 7.204E-3 3.917E-2
2.278E-1
1.000E0
 1 87
26 GGCAGTG,MIR-324-3P:MSigDB GGCAGTG,MIR-324-3P:MSigDB MSigDB 7.204E-3 3.917E-2
2.278E-1
1.000E0
 1 87
27 hsa-miR-548m:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 3.917E-2
2.278E-1
1.000E0
 1 95
28 hsa-miR-938:PITA hsa-miR-938:PITA TOP PITA 8.112E-3 3.917E-2
2.278E-1
1.000E0
 1 98
29 hsa-miR-621:PITA hsa-miR-621:PITA TOP PITA 8.360E-3 3.917E-2
2.278E-1
1.000E0
 1 101
30 hsa-miR-345:PITA hsa-miR-345:PITA TOP PITA 8.442E-3 3.917E-2
2.278E-1
1.000E0
 1 102
31 hsa-miR-3124:mirSVR lowEffct hsa-miR-3124:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.102E-3 3.917E-2
2.278E-1
1.000E0
 1 110
32 hsa-miR-383-5p:Functional MTI Functional MTI miRTarbase 9.267E-3 3.917E-2
2.278E-1
1.000E0
 1 112
33 hsa-miR-4496:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.843E-3 3.917E-2
2.278E-1
1.000E0
 1 119
34 hsa-miR-5694:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.009E-2 3.917E-2
2.278E-1
1.000E0
 1 122
35 hsa-miR-423-3p:mirSVR highEffct hsa-miR-423-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.009E-2 3.917E-2
2.278E-1
1.000E0
 1 122
36 hsa-miR-655-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.026E-2 3.917E-2
2.278E-1
1.000E0
 1 124
37 hsa-miR-4451:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.058E-2 3.917E-2
2.278E-1
1.000E0
 1 128
38 hsa-miR-133a-3p:Functional MTI Functional MTI miRTarbase 1.075E-2 3.917E-2
2.278E-1
1.000E0
 1 130
39 hsa-miR-4696:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 3.917E-2
2.278E-1
1.000E0
 1 135
40 hsa-miR-383:PITA hsa-miR-383:PITA TOP PITA 1.133E-2 3.917E-2
2.278E-1
1.000E0
 1 137
41 GAGCCAG,MIR-149:MSigDB GAGCCAG,MIR-149:MSigDB MSigDB 1.141E-2 3.917E-2
2.278E-1
1.000E0
 1 138
42 CTCTGGA,MIR-525:MSigDB CTCTGGA,MIR-525:MSigDB MSigDB 1.165E-2 3.917E-2
2.278E-1
1.000E0
 1 141
43 CTCTGGA,MIR-520A:MSigDB CTCTGGA,MIR-520A:MSigDB MSigDB 1.165E-2 3.917E-2
2.278E-1
1.000E0
 1 141
44 hsa-miR-551b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.190E-2 3.917E-2
2.278E-1
1.000E0
 1 144
45 hsa-miR-582-5p:Functional MTI Functional MTI miRTarbase 1.231E-2 3.917E-2
2.278E-1
1.000E0
 1 149
46 hsa-miR-451b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.239E-2 3.917E-2
2.278E-1
1.000E0
 1 150
47 GTGACTT,MIR-224:MSigDB GTGACTT,MIR-224:MSigDB MSigDB 1.239E-2 3.917E-2
2.278E-1
1.000E0
 1 150
48 hsa-miR-6501-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.297E-2 3.917E-2
2.278E-1
1.000E0
 1 157
49 hsa-miR-1252-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.346E-2 3.917E-2
2.278E-1
1.000E0
 1 163
50 hsa-miR-365:PITA hsa-miR-365:PITA TOP PITA 1.387E-2 3.917E-2
2.278E-1
1.000E0
 1 168
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 1921 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D003676 Deferoxamine CTD 2.023E-10 3.885E-7 3.162E-6 3.885E-7 5 186
2 ctd:D006427 Hemin CTD 3.839E-9 3.687E-6 3.001E-5 7.374E-6 4 93
3 ctd:D007501 Iron CTD 7.545E-9 4.831E-6 3.932E-5 1.449E-5 5 382
4 CID000004973 heme b Stitch 1.603E-8 6.665E-6 5.424E-5 3.079E-5 5 444
5 CID000000137 5-aminolevulinic acid Stitch 1.735E-8 6.665E-6 5.424E-5 3.332E-5 4 135
6 CID005353883 NSC368648 Stitch 3.291E-8 9.206E-6 7.492E-5 6.323E-5 3 28
7 CID003086464 heme arginate Stitch 4.515E-8 9.206E-6 7.492E-5 8.673E-5 3 31
8 CID000135006 pregnanedione Stitch 5.751E-8 9.206E-6 7.492E-5 1.105E-4 2 2
9 ctd:C005038 homocarnosine CTD 5.751E-8 9.206E-6 7.492E-5 1.105E-4 2 2
10 ctd:D005561 Formates CTD 5.751E-8 9.206E-6 7.492E-5 1.105E-4 2 2
11 ctd:D000861 Anserine CTD 5.751E-8 9.206E-6 7.492E-5 1.105E-4 2 2
12 CID000440714 2-amino-3-ketoadipate Stitch 5.751E-8 9.206E-6 7.492E-5 1.105E-4 2 2
13 CID000073270 5-sulfaminouracil Stitch 7.799E-8 1.084E-5 8.824E-5 1.498E-4 3 37
14 CID000000321 coproporphyrinogen III Stitch 8.467E-8 1.084E-5 8.824E-5 1.627E-4 3 38
15 CID000009732 4-fluorophenol Stitch 8.467E-8 1.084E-5 8.824E-5 1.627E-4 3 38
16 ctd:D005297 Ferrozine CTD 1.725E-7 2.071E-5 1.685E-4 3.314E-4 2 3
17 DB00893 Iron Dextran Drug Bank 3.450E-7 3.898E-5 3.172E-4 6.627E-4 2 4
18 CID000029863 metoxuron Stitch 5.718E-7 5.812E-5 4.730E-4 1.098E-3 3 71
19 CID000128553 2,3,5-trichlorophenyl methyl sulfone Stitch 5.749E-7 5.812E-5 4.730E-4 1.104E-3 2 5
20 CID000002973 deferoxamine Stitch 7.320E-7 7.031E-5 5.722E-4 1.406E-3 4 343
21 CID000009414 Zectran Stitch 8.622E-7 7.084E-5 5.765E-4 1.656E-3 2 6
22 CID000100800 thioacetamide-S-oxide Stitch 8.622E-7 7.084E-5 5.765E-4 1.656E-3 2 6
23 CID000137957 AC1L3BQY Stitch 8.622E-7 7.084E-5 5.765E-4 1.656E-3 2 6
24 CID000007516 phenylhydrazine Stitch 8.850E-7 7.084E-5 5.765E-4 1.700E-3 3 82
25 CID000168414 heptacarboxylic porphyrin Stitch 1.207E-6 9.274E-5 7.547E-4 2.318E-3 2 7
26 CID000002416 BMS-186282 Stitch 1.381E-6 1.021E-4 8.306E-4 2.654E-3 3 95
27 CID000161295 AC1L4P5P Stitch 1.609E-6 1.104E-4 8.984E-4 3.091E-3 2 8
28 CID003081462 harderoporphyrin Stitch 1.609E-6 1.104E-4 8.984E-4 3.091E-3 2 8
29 ctd:C020748 ferrous sulfate CTD 1.923E-6 1.274E-4 1.037E-3 3.695E-3 3 106
30 CID000161350 cobalt mesoporphyrin Stitch 2.069E-6 1.325E-4 1.078E-3 3.974E-3 2 9
31 CID000098810 6-oxoheptanoic acid Stitch 2.210E-6 1.370E-4 1.115E-3 4.246E-3 3 111
32 ctd:C025340 manganese chloride CTD 2.318E-6 1.392E-4 1.133E-3 4.454E-3 4 458
33 CID000086453 first rate Stitch 3.159E-6 1.686E-4 1.372E-3 6.069E-3 2 11
34 ctd:C023844 potassium nitrate CTD 3.159E-6 1.686E-4 1.372E-3 6.069E-3 2 11
35 CID000455606 AC1L9T6Z Stitch 3.159E-6 1.686E-4 1.372E-3 6.069E-3 2 11
36 CID000019388 EBIs Stitch 3.159E-6 1.686E-4 1.372E-3 6.069E-3 2 11
37 CID004472505 2-amino-4-methoxy-3-butenoic acid Stitch 3.791E-6 1.968E-4 1.602E-3 7.282E-3 2 12
38 CID009548659 porphyrinogen Stitch 4.480E-6 2.265E-4 1.843E-3 8.605E-3 2 13
39 CID000066868 porphyrin Stitch 4.840E-6 2.384E-4 1.940E-3 9.298E-3 3 144
40 CID000024288 cobalt(II) chloride Stitch 5.045E-6 2.390E-4 1.945E-3 9.692E-3 3 146
41 ctd:C030735 7-aminocephalosporanic acid CTD 5.226E-6 2.390E-4 1.945E-3 1.004E-2 2 14
42 ctd:C036617 salsolinol CTD 5.226E-6 2.390E-4 1.945E-3 1.004E-2 2 14
43 CID000004971 protoporphyrin Stitch 5.583E-6 2.494E-4 2.030E-3 1.072E-2 3 151
44 ctd:D017665 Hydroxyl Radical CTD 6.029E-6 2.632E-4 2.142E-3 1.158E-2 2 15
45 CID000072423 uroporphyrin III Stitch 6.889E-6 2.877E-4 2.341E-3 1.323E-2 2 16
46 ctd:C436526 EUK-189 CTD 6.889E-6 2.877E-4 2.341E-3 1.323E-2 2 16
47 CID000119412 4,5-dioxovalerate Stitch 7.807E-6 3.124E-4 2.543E-3 1.500E-2 2 17
48 ctd:D008299 Maleic Anhydrides CTD 7.807E-6 3.124E-4 2.543E-3 1.500E-2 2 17
49 CID000440776 coproporphyrinogen I Stitch 8.782E-6 3.443E-4 2.802E-3 1.687E-2 2 18
50 CID004474585 Ethyl carbylamine Stitch 9.814E-6 3.697E-4 3.008E-3 1.885E-2 2 19
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 224 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0282193 Iron Overload DisGeNET Curated 1.645E-11 3.686E-9 2.208E-8 3.686E-9 5 81
2 C3469186 HEMOCHROMATOSIS, TYPE 1 DisGeNET Curated 1.111E-6 1.244E-4 7.453E-4 2.488E-4 3 63
3 C0018995 Hemochromatosis DisGeNET Curated 2.123E-6 1.342E-4 8.043E-4 4.756E-4 3 78
4 C1853578 Neuroferritinopathy DisGeNET Curated 2.397E-6 1.342E-4 8.043E-4 5.370E-4 2 7
5 C0162568 Erythropoietic Protoporphyria DisGeNET Curated 5.134E-6 2.300E-4 1.378E-3 1.150E-3 2 10
6 C3854388 Hyperferritinaemia DisGeNET Curated 1.038E-5 2.905E-4 1.741E-3 2.324E-3 2 14
7 C0241013 Serum ferritin increased DisGeNET Curated 1.038E-5 2.905E-4 1.741E-3 2.324E-3 2 14
8 C0743912 Increased ferritin DisGeNET Curated 1.038E-5 2.905E-4 1.741E-3 2.324E-3 2 14
9 C0271901 Microcytic hypochromic anemia (disorder) DisGeNET Curated 1.743E-5 4.339E-4 2.600E-3 3.905E-3 2 18
10 C0085576 Iron-Refractory Iron Deficiency Anemia DisGeNET Curated 4.947E-5 1.108E-3 6.639E-3 1.108E-2 2 30
11 C0162565 Acute intermittent porphyria DisGeNET Curated 8.856E-5 1.803E-3 1.080E-2 1.984E-2 2 40
12 C0240066 Iron deficiency DisGeNET BeFree 2.209E-4 2.304E-3 1.380E-2 4.948E-2 2 63
13 C0002871 Anemia DisGeNET Curated 3.691E-4 2.304E-3 1.380E-2
8.268E-2
 3 438
14 OMIN:600886 HYPERFERRITINEMIA-CATARACT SYNDROME OMIM 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
15 C0241012 Serum ferritin decreased DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
16 cv:C1853578 Neuroferritinopathy Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
17 C4023007 Increased erythrocyte protoporphyrin concentration DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
18 C0339946 Pulmonary tularemia DisGeNET BeFree 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
19 OMIN:611783 ERYTHROCYTOSIS, FAMILIAL, 4; ECYT4 OMIM 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
20 C2673187 Erythrocytosis, Familial, 4 DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
21 cv:C2677889 Protoporphyria, erythropoietic, X-linked Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
22 OMIN:300752 PROTOPORPHYRIA, ERYTHROPOIETIC, X-LINKED DOMINANT; XLDPP OMIM 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
23 C3806153 ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD 1 DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
24 OMIN:206100 ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD OMIM 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
25 C4025183 Macrocytic dyserythropoietic anemia DisGeNET BeFree 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
26 C4024952 Cavitation of the basal ganglia DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
27 cv:C2673187 Erythrocytosis, familial, 4 Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
28 cv:C1833213 Hyperferritinemia cataract syndrome Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
29 cv:C0221018 Hereditary sideroblastic anemia Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
30 C3810090 L-FERRITIN DEFICIENCY DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
31 cv:C2673913 Hypochromic microcytic anemia with iron overload Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
32 OMIN:606159 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 3; NBIA3 OMIM 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
33 cv:CN183734 L-ferritin deficiency Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
34 C2677889 Protoporphyria, Erythropoietic, X-Linked Dominant DisGeNET Curated 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
35 cv:CN181217 Hemochromatosis, type 5 Clinical Variations 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
36 OMIN:300751 ANEMIA, SIDEROBLASTIC, X-LINKED; XLSA OMIM 3.703E-4 2.304E-3 1.380E-2
8.294E-2
 1 1
37 C4023583 Abnormality of iron homeostasis DisGeNET Curated 7.404E-4 4.253E-3 2.548E-2
1.658E-1
 1 2
38 C0854279 Basal ganglion degeneration DisGeNET BeFree 7.404E-4 4.253E-3 2.548E-2
1.658E-1
 1 2
39 C1851316 Iron Overload, Autosomal Dominant DisGeNET Curated 7.404E-4 4.253E-3 2.548E-2
1.658E-1
 1 2
40 C0162119 Hemoglobin low DisGeNET Curated 8.955E-4 5.015E-3 3.004E-2
2.006E-1
 2 127
41 C4021768 Abnormality of metabolism/homeostasis DisGeNET Curated 1.026E-3 5.076E-3 3.041E-2
2.298E-1
 2 136
42 C0007786 Brain Ischemia DisGeNET Curated 1.041E-3 5.076E-3 3.041E-2
2.332E-1
 2 137
43 C2673913 Anemia, Hypochromic Microcytic, With Iron Overload DisGeNET Curated 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
44 C1368041 Pancreatic Somatostatinoma DisGeNET BeFree 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
45 C0340044 Acute exacerbation of chronic obstructive airways disease DisGeNET BeFree 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
46 C0026709 Mucopolysaccharidosis VI DisGeNET Curated 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
47 C4045968 Altitude Hypoxia DisGeNET BeFree 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
48 C0002351 Altitude Sickness DisGeNET BeFree 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
49 C0234517 Anarthria speech disorder DisGeNET Curated 1.110E-3 5.076E-3 3.041E-2
2.487E-1
 1 3
50 C0027626 Neoplasm Invasiveness DisGeNET Curated 1.133E-3 5.077E-3 3.042E-2
2.539E-1
 2 143
Show 45 more annotations