Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc325_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 19 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003743 translation initiation factor activity 2.469E-10 4.691E-9 1.664E-8 4.691E-9 4 51
2 GO:0008135 translation factor activity, RNA binding 2.520E-9 1.671E-8 5.929E-8 4.788E-8 4 90
3 GO:0000339 RNA cap binding 2.639E-9 1.671E-8 5.929E-8 5.014E-8 3 13
4 GO:0008190 eukaryotic initiation factor 4E binding 2.582E-6 1.227E-5 4.352E-5 4.907E-5 2 10
5 GO:0031369 translation initiation factor binding 3.405E-5 1.294E-4 4.591E-4 6.470E-4 2 35
6 GO:0030371 translation repressor activity 6.148E-3 1.947E-2
6.907E-2
1.168E-1
 1 23
7 GO:0045182 translation regulator activity 1.120E-2 3.041E-2
1.079E-1
2.129E-1
 1 42
8 GO:0004004 ATP-dependent RNA helicase activity 1.756E-2 3.437E-2
1.219E-1
3.337E-1
 1 66
9 GO:0008186 RNA-dependent ATPase activity 1.756E-2 3.437E-2
1.219E-1
3.337E-1
 1 66
10 GO:0003725 double-stranded RNA binding 1.809E-2 3.437E-2
1.219E-1
3.437E-1
 1 68
11 GO:0003724 RNA helicase activity 1.994E-2 3.444E-2
1.222E-1
3.788E-1
 1 75
12 GO:0070035 purine NTP-dependent helicase activity 2.965E-2 4.334E-2
1.538E-1
5.634E-1
 1 112
13 GO:0008026 ATP-dependent helicase activity 2.965E-2 4.334E-2
1.538E-1
5.634E-1
 1 112
Show 8 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 49 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006413 translational initiation 1.165E-10 5.710E-9 2.558E-8 5.710E-9 5 194
2 GO:0006446 regulation of translational initiation 1.919E-9 3.566E-8 1.597E-7 9.403E-8 4 84
3 GO:0006417 regulation of translation 2.183E-9 3.566E-8 1.597E-7 1.070E-7 5 347
4 GO:0034248 regulation of cellular amide metabolic process 3.447E-9 4.222E-8 1.891E-7 1.689E-7 5 380
5 GO:0010608 posttranscriptional regulation of gene expression 1.058E-8 1.036E-7 4.642E-7 5.182E-7 5 475
6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 2.851E-5 2.329E-4 1.043E-3 1.397E-3 2 32
7 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1.304E-4 9.131E-4 4.090E-3 6.392E-3 2 68
8 GO:0017148 negative regulation of translation 5.929E-4 3.631E-3 1.627E-2 2.905E-2 2 145
9 GO:0034249 negative regulation of cellular amide metabolic process 6.684E-4 3.639E-3 1.630E-2 3.275E-2 2 154
10 GO:0000956 nuclear-transcribed mRNA catabolic process 1.146E-3 5.615E-3 2.515E-2
5.615E-2
 2 202
11 GO:0006402 mRNA catabolic process 1.333E-3 5.937E-3 2.659E-2
6.530E-2
 2 218
12 GO:0060903 positive regulation of meiosis I 1.610E-3 6.432E-3 2.881E-2
7.889E-2
 1 6
13 GO:0006401 RNA catabolic process 1.706E-3 6.432E-3 2.881E-2
8.362E-2
 2 247
14 GO:0060631 regulation of meiosis I 2.414E-3 8.450E-3 3.785E-2
1.183E-1
 1 9
15 GO:0045836 positive regulation of meiotic nuclear division 4.556E-3 1.433E-2
6.421E-2
2.233E-1
 1 17
16 GO:0034655 nucleobase-containing compound catabolic process 4.805E-3 1.433E-2
6.421E-2
2.355E-1
 2 418
17 GO:0051446 positive regulation of meiotic cell cycle 5.359E-3 1.433E-2
6.421E-2
2.626E-1
 1 20
18 GO:0044270 cellular nitrogen compound catabolic process 5.844E-3 1.433E-2
6.421E-2
2.863E-1
 2 462
19 GO:0046700 heterocycle catabolic process 5.893E-3 1.433E-2
6.421E-2
2.888E-1
 2 464
20 GO:0045947 negative regulation of translational initiation 5.893E-3 1.433E-2
6.421E-2
2.888E-1
 1 22
21 GO:0019439 aromatic compound catabolic process 6.143E-3 1.433E-2
6.421E-2
3.010E-1
 2 474
22 GO:0040020 regulation of meiotic nuclear division 8.830E-3 1.967E-2
8.809E-2
4.327E-1
 1 33
23 GO:0001662 behavioral fear response 1.149E-2 2.266E-2
1.015E-1
5.632E-1
 1 43
24 GO:0002209 behavioral defense response 1.176E-2 2.266E-2
1.015E-1
5.762E-1
 1 44
25 GO:0051445 regulation of meiotic cell cycle 1.202E-2 2.266E-2
1.015E-1
5.892E-1
 1 45
26 GO:0010501 RNA secondary structure unwinding 1.202E-2 2.266E-2
1.015E-1
5.892E-1
 1 45
27 GO:0042596 fear response 1.256E-2 2.279E-2
1.021E-1
6.153E-1
 1 47
28 GO:2000243 positive regulation of reproductive process 1.680E-2 2.940E-2
1.317E-1
8.233E-1
 1 63
29 GO:0051785 positive regulation of nuclear division 1.760E-2 2.973E-2
1.332E-1
8.622E-1
 1 66
30 GO:0031100 animal organ regeneration 2.393E-2 3.908E-2
1.750E-1
1.000E0
 1 90
31 GO:0033555 multicellular organismal response to stress 2.472E-2 3.908E-2
1.750E-1
1.000E0
 1 93
32 GO:0007127 meiosis I 2.735E-2 4.178E-2
1.872E-1
1.000E0
 1 103
33 GO:0045727 positive regulation of translation 2.814E-2 4.178E-2
1.872E-1
1.000E0
 1 106
34 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 3.207E-2 4.622E-2
2.070E-1
1.000E0
 1 121
35 GO:0034250 positive regulation of cellular amide metabolic process 3.312E-2 4.636E-2
2.077E-1
1.000E0
 1 125
36 GO:0051781 positive regulation of cell division 3.703E-2 4.914E-2
2.201E-1
1.000E0
 1 140
37 GO:0043488 regulation of mRNA stability 3.807E-2 4.914E-2
2.201E-1
1.000E0
 1 144
38 GO:0043487 regulation of RNA stability 3.911E-2 4.914E-2
2.201E-1
1.000E0
 1 148
39 GO:2000241 regulation of reproductive process 3.911E-2 4.914E-2
2.201E-1
1.000E0
 1 148
Show 34 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 3 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016281 eukaryotic translation initiation factor 4F complex 1.146E-13 3.437E-13 6.301E-13 3.437E-13 4 9
2 GO:0005845 mRNA cap binding complex 3.144E-3 3.667E-3 6.724E-3 9.432E-3 1 12
3 GO:0034518 RNA cap binding complex 3.667E-3 3.667E-3 6.724E-3 1.100E-2 1 14

4: Human Phenotype [Display Chart] 2 input genes in category / 8 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 27 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 5 input genes in category / 38 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS51366 MI PROSITE 8.544E-7 5.681E-6 2.402E-5 3.247E-5 2 6
2 IPR003891 Initiation fac eIF4g MI InterPro 8.544E-7 5.681E-6 2.402E-5 3.247E-5 2 6
3 PF02847 MA3 Pfam 8.544E-7 5.681E-6 2.402E-5 3.247E-5 2 6
4 SM00544 MA3 SMART 8.544E-7 5.681E-6 2.402E-5 3.247E-5 2 6
5 IPR003307 W2 domain InterPro 1.196E-6 5.681E-6 2.402E-5 4.545E-5 2 7
6 PS51363 W2 PROSITE 1.196E-6 5.681E-6 2.402E-5 4.545E-5 2 7
7 PF02020 W2 Pfam 1.196E-6 5.681E-6 2.402E-5 4.545E-5 2 7
8 SM00515 eIF5C SMART 1.196E-6 5.681E-6 2.402E-5 4.545E-5 2 7
9 PF02854 MIF4G Pfam 2.562E-6 8.851E-6 3.742E-5 9.736E-5 2 10
10 SM00543 MIF4G SMART 2.562E-6 8.851E-6 3.742E-5 9.736E-5 2 10
11 IPR003890 MIF4G-like typ-3 InterPro 2.562E-6 8.851E-6 3.742E-5 9.736E-5 2 10
12 IPR016021 MIF4-like InterPro 5.975E-6 1.747E-5 7.384E-5 2.270E-4 2 15
13 1.25.40.180 - Gene3D 5.975E-6 1.747E-5 7.384E-5 2.270E-4 2 15
14 IPR031258 EIF4A1/2 InterPro 5.337E-4 1.449E-3 6.125E-3 2.028E-2 1 2
15 PF05456 eIF 4EBP Pfam 8.005E-4 1.789E-3 7.565E-3 3.042E-2 1 3
16 IPR008606 EIF4EBP InterPro 8.005E-4 1.789E-3 7.565E-3 3.042E-2 1 3
17 IPR019770 TIF eIF 4E CS InterPro 8.005E-4 1.789E-3 7.565E-3 3.042E-2 1 3
18 PF01652 IF4E Pfam 1.067E-3 2.134E-3 9.024E-3 4.055E-2 1 4
19 PS00813 IF4E PROSITE 1.067E-3 2.134E-3 9.024E-3 4.055E-2 1 4
20 IPR023398 TIF eIF4e-like InterPro 1.334E-3 2.304E-3 9.741E-3
5.069E-2
 1 5
21 3.30.760.10 - Gene3D 1.334E-3 2.304E-3 9.741E-3
5.069E-2
 1 5
22 IPR001040 TIF eIF 4E InterPro 1.334E-3 2.304E-3 9.741E-3
5.069E-2
 1 5
23 IPR016024 ARM-type fold InterPro 3.167E-3 5.232E-3 2.212E-2
1.203E-1
 2 340
24 PS00039 DEAD ATP HELICASE PROSITE 8.247E-3 1.306E-2
5.521E-2
3.134E-1
 1 31
25 IPR000629 RNA-helicase DEAD-box CS InterPro 8.777E-3 1.334E-2
5.640E-2
3.335E-1
 1 33
26 PS51195 Q MOTIF PROSITE 9.837E-3 1.384E-2
5.853E-2
3.738E-1
 1 37
27 IPR014014 RNA helicase DEAD Q motif InterPro 9.837E-3 1.384E-2
5.853E-2
3.738E-1
 1 37
28 IPR000357 HEAT InterPro 1.539E-2 2.088E-2
8.828E-2
5.846E-1
 1 58
29 PS50077 HEAT REPEAT PROSITE 1.854E-2 2.370E-2
1.002E-1
7.047E-1
 1 70
30 PF00270 DEAD Pfam 1.933E-2 2.370E-2
1.002E-1
7.347E-1
 1 73
31 IPR011545 DEAD/DEAH box helicase dom InterPro 1.933E-2 2.370E-2
1.002E-1
7.347E-1
 1 73
32 SM00490 HELICc SMART 2.823E-2 2.902E-2
1.227E-1
1.000E0
 1 107
33 PF00271 Helicase C Pfam 2.823E-2 2.902E-2
1.227E-1
1.000E0
 1 107
34 IPR001650 Helicase C InterPro 2.850E-2 2.902E-2
1.227E-1
1.000E0
 1 108
35 SM00487 DEXDc SMART 2.876E-2 2.902E-2
1.227E-1
1.000E0
 1 109
36 PS51192 HELICASE ATP BIND 1 PROSITE 2.876E-2 2.902E-2
1.227E-1
1.000E0
 1 109
37 PS51194 HELICASE CTER PROSITE 2.876E-2 2.902E-2
1.227E-1
1.000E0
 1 109
38 IPR014001 Helicase ATP-bd InterPro 2.902E-2 2.902E-2
1.227E-1
1.000E0
 1 110
Show 33 more annotations

7: Pathway [Display Chart] 5 input genes in category / 41 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 177876 RNA transport BioSystems: KEGG 4.612E-10 1.891E-8 8.136E-8 1.891E-8 5 171
2 1269316 Antiviral mechanism by IFN-stimulated genes BioSystems: REACTOME 6.731E-9 9.199E-8 3.958E-7 2.760E-7 4 77
3 1269317 ISG15 antiviral mechanism BioSystems: REACTOME 6.731E-9 9.199E-8 3.958E-7 2.760E-7 4 77
4 M7721 Eukaryotic protein translation MSigDB C2 BIOCARTA (v6.0) 1.739E-8 1.782E-7 7.669E-7 7.129E-7 3 16
5 M16563 mTOR Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 5.494E-8 4.290E-7 1.846E-6 2.253E-6 3 23
6 M4791 Regulation of eIF4e and p70 S6 Kinase MSigDB C2 BIOCARTA (v6.0) 6.279E-8 4.290E-7 1.846E-6 2.574E-6 3 24
7 1269311 Interferon Signaling BioSystems: REACTOME 3.322E-7 1.946E-6 8.372E-6 1.362E-5 4 202
8 1269713 Deadenylation of mRNA BioSystems: REACTOME 3.857E-5 1.977E-4 8.506E-4 1.581E-3 2 25
9 1269712 Deadenylation-dependent mRNA decay BioSystems: REACTOME 2.041E-4 8.380E-4 3.606E-3 8.370E-3 2 57
10 125138 Viral myocarditis BioSystems: KEGG 2.188E-4 8.380E-4 3.606E-3 8.970E-3 2 59
11 1268685 Ribosomal scanning and start codon recognition BioSystems: REACTOME 2.496E-4 8.380E-4 3.606E-3 1.023E-2 2 63
12 1268684 Translation initiation complex formation BioSystems: REACTOME 2.576E-4 8.380E-4 3.606E-3 1.056E-2 2 64
13 1268683 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S BioSystems: REACTOME 2.657E-4 8.380E-4 3.606E-3 1.089E-2 2 65
14 169351 Validated targets of C-MYC transcriptional activation BioSystems: Pathway Interaction Database 4.128E-4 1.209E-3 5.202E-3 1.693E-2 2 81
15 1268686 GTP hydrolysis and joining of the 60S ribosomal subunit BioSystems: REACTOME 8.891E-4 2.278E-3 9.803E-3 3.645E-2 2 119
16 1268688 L13a-mediated translational silencing of Ceruloplasmin expression BioSystems: REACTOME 8.891E-4 2.278E-3 9.803E-3 3.645E-2 2 119
17 1268680 Cap-dependent Translation Initiation BioSystems: REACTOME 1.012E-3 2.305E-3 9.917E-3 4.149E-2 2 127
18 1268679 Eukaryotic Translation Initiation BioSystems: REACTOME 1.012E-3 2.305E-3 9.917E-3 4.149E-2 2 127
19 1268678 Translation BioSystems: REACTOME 1.701E-3 3.670E-3 1.579E-2
6.973E-2
 2 165
20 1269438 mTORC1-mediated signalling BioSystems: REACTOME 9.204E-3 1.887E-2
8.119E-2
3.774E-1
 1 23
21 1269436 mTOR signalling BioSystems: REACTOME 1.596E-2 3.049E-2
1.312E-1
6.545E-1
 1 40
22 1269434 PKB-mediated events BioSystems: REACTOME 1.636E-2 3.049E-2
1.312E-1
6.708E-1
 1 41
23 1269726 AUF1 (hnRNP D0) binds and destabilizes mRNA BioSystems: REACTOME 2.347E-2 4.145E-2
1.784E-1
9.625E-1
 1 59
24 138001 mTOR signaling pathway BioSystems: Pathway Interaction Database 2.426E-2 4.145E-2
1.784E-1
9.948E-1
 1 61
Show 19 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 390 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9418880 A novel functional human eukaryotic translation initiation factor 4G. Pubmed 1.077E-11 4.200E-9 2.749E-8 4.200E-9 3 5
2 15153109 Characterization of mammalian eIF4E-family members. Pubmed 3.769E-11 7.350E-9 4.810E-8 1.470E-8 3 7
3 23478064 Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Pubmed 1.371E-8 6.684E-7 4.375E-6 5.347E-6 2 2
4 10872469 eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Pubmed 1.371E-8 6.684E-7 4.375E-6 5.347E-6 2 2
5 18606994 Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Pubmed 1.371E-8 6.684E-7 4.375E-6 5.347E-6 2 2
6 23023399 Translational repression precedes and is required for ZAP-mediated mRNA decay. Pubmed 1.371E-8 6.684E-7 4.375E-6 5.347E-6 2 2
7 21377182 Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation. Pubmed 1.371E-8 6.684E-7 4.375E-6 5.347E-6 2 2
8 17130132 Functional analysis of individual binding activities of the scaffold protein eIF4G. Pubmed 1.371E-8 6.684E-7 4.375E-6 5.347E-6 2 2
9 9857202 A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
10 17284590 Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
11 10880459 Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
12 19153607 Structural basis for translational inhibition by the tumour suppressor Pdcd4. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
13 17060447 Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
14 18296639 PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
15 21840318 Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
16 19203580 Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Pubmed 4.113E-8 1.003E-6 6.561E-6 1.604E-5 2 3
17 8449919 The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A. Pubmed 8.226E-8 1.528E-6 9.998E-6 3.208E-5 2 4
18 11408474 Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo. Pubmed 8.226E-8 1.528E-6 9.998E-6 3.208E-5 2 4
19 9372926 Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Pubmed 8.226E-8 1.528E-6 9.998E-6 3.208E-5 2 4
20 24248602 Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. Pubmed 8.226E-8 1.528E-6 9.998E-6 3.208E-5 2 4
21 21454508 Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor. Pubmed 8.226E-8 1.528E-6 9.998E-6 3.208E-5 2 4
22 22678294 An oxygen-regulated switch in the protein synthesis machinery. Pubmed 1.371E-7 2.139E-6 1.400E-5 5.347E-5 2 5
23 9878069 Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. Pubmed 1.371E-7 2.139E-6 1.400E-5 5.347E-5 2 5
24 27864334 Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Pubmed 1.371E-7 2.139E-6 1.400E-5 5.347E-5 2 5
25 16648488 Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Pubmed 1.371E-7 2.139E-6 1.400E-5 5.347E-5 2 5
26 18426977 eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. Pubmed 2.056E-7 2.765E-6 1.810E-5 8.019E-5 2 6
27 16932749 p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. Pubmed 2.056E-7 2.765E-6 1.810E-5 8.019E-5 2 6
28 10022874 Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Pubmed 2.056E-7 2.765E-6 1.810E-5 8.019E-5 2 6
29 26095252 Differential Requirements for eIF4E Dose in Normal Development and Cancer. Pubmed 2.056E-7 2.765E-6 1.810E-5 8.019E-5 2 6
30 17053147 S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Pubmed 2.879E-7 3.742E-6 2.449E-5 1.123E-4 2 7
31 24768540 A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Pubmed 3.838E-7 4.677E-6 3.061E-5 1.497E-4 2 8
32 16541103 mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin. Pubmed 3.838E-7 4.677E-6 3.061E-5 1.497E-4 2 8
33 15361857 eIF4G is required for the pioneer round of translation in mammalian cells. Pubmed 4.934E-7 5.660E-6 3.704E-5 1.924E-4 2 9
34 22586265 Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Pubmed 4.934E-7 5.660E-6 3.704E-5 1.924E-4 2 9
35 21182205 Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Pubmed 2.583E-6 2.878E-5 1.884E-4 1.007E-3 3 245
36 25940091 La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). Pubmed 8.173E-5 4.364E-4 2.856E-3 3.188E-2 2 110
37 11606767 HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
38 9139875 Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
39 16236269 Effect of leptin on liver alcohol dehydrogenase. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
40 24471916 Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
41 25079319 RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
42 8961935 A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
43 12054764 In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
44 22707335 Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
45 23112151 DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
46 7601469 Human protein synthesis initiation factor eIF-4 gamma is encoded by a single gene (EIF4G) that maps to chromosome 3q27-qter. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
47 24704100 EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
48 23490116 Mutations in EIF4G1 are not a common cause of Parkinson's disease. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
49 15713657 Embryonic poly(A)-binding protein stimulates translation in germ cells. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
50 25765080 The EIF4G1 gene and Parkinson's disease. Pubmed 1.309E-4 4.364E-4 2.856E-3
5.106E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 335 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:EIF4E EIF4E interactions 9.925E-10 3.325E-7 2.125E-6 3.325E-7 4 68
2 int:EIF4G3 EIF4G3 interactions 1.428E-7 2.391E-5 1.529E-4 4.782E-5 3 44
3 int:EIF4A2 EIF4A2 interactions 6.413E-7 7.161E-5 4.578E-4 2.148E-4 3 72
4 int:EIF4G2 EIF4G2 interactions 9.515E-7 7.969E-5 5.094E-4 3.188E-4 3 82
5 int:EIF3B EIF3B interactions 1.788E-6 1.099E-4 7.024E-4 5.989E-4 3 101
6 int:EIF3F EIF3F interactions 2.069E-6 1.099E-4 7.024E-4 6.930E-4 3 106
7 int:EIF4EBP3 EIF4EBP3 interactions 2.296E-6 1.099E-4 7.024E-4 7.691E-4 2 9
8 int:EIF3H EIF3H interactions 2.859E-6 1.197E-4 7.654E-4 9.578E-4 3 118
9 int:EIF4A1 EIF4A1 interactions 3.828E-6 1.312E-4 8.390E-4 1.282E-3 3 130
10 int:EIF4G1 EIF4G1 interactions 3.918E-6 1.312E-4 8.390E-4 1.312E-3 3 131
11 int:RPTOR RPTOR interactions 2.265E-5 6.897E-4 4.409E-3 7.586E-3 3 235
12 int:OTUD6B OTUD6B interactions 3.155E-5 8.807E-4 5.630E-3 1.057E-2 2 32
13 int:PABPC1 PABPC1 interactions 3.865E-5 9.584E-4 6.127E-3 1.295E-2 3 281
14 int:NFATC2IP NFATC2IP interactions 4.005E-5 9.584E-4 6.127E-3 1.342E-2 2 36
15 int:MKNK1 MKNK1 interactions 5.736E-5 1.281E-3 8.190E-3 1.922E-2 2 43
16 int:PUS7 PUS7 interactions 6.288E-5 1.316E-3 8.416E-3 2.106E-2 2 45
17 int:PDCD4 PDCD4 interactions 1.048E-4 2.066E-3 1.321E-2 3.512E-2 2 58
18 int:USP10 USP10 interactions 1.664E-4 2.934E-3 1.875E-2
5.574E-2
 2 73
19 int:KIF1B KIF1B interactions 1.664E-4 2.934E-3 1.875E-2
5.574E-2
 2 73
20 int:TAF2 TAF2 interactions 2.204E-4 3.692E-3 2.360E-2
7.384E-2
 2 84
21 int:UPF2 UPF2 interactions 2.879E-4 4.476E-3 2.862E-2
9.646E-2
 2 96
22 int:EIF4B EIF4B interactions 2.940E-4 4.476E-3 2.862E-2
9.848E-2
 2 97
23 int:EIF3I EIF3I interactions 4.130E-4 6.016E-3 3.846E-2
1.384E-1
 2 115
24 int:LIG4 LIG4 interactions 5.686E-4 7.846E-3
5.016E-2
1.905E-1
 2 135
25 int:EIF3A EIF3A interactions 5.855E-4 7.846E-3
5.016E-2
1.962E-1
 2 137
26 int:EIF4E2 EIF4E2 interactions 7.107E-4 9.157E-3
5.854E-2
2.381E-1
 2 151
27 int:SF3A2 SF3A2 interactions 7.679E-4 9.528E-3
6.091E-2
2.573E-1
 2 157
28 int:PABPC4 PABPC4 interactions 8.579E-4 1.026E-2
6.562E-2
2.874E-1
 2 166
29 int:LGR4 LGR4 interactions 1.433E-3 1.615E-2
1.033E-1
4.801E-1
 2 215
30 int:PSMC3 PSMC3 interactions 1.446E-3 1.615E-2
1.033E-1
4.845E-1
 2 216
31 int:ATP5F1A ATP5F1A interactions 1.638E-3 1.719E-2
1.099E-1
5.487E-1
 2 230
32 int:PLPPR4 PLPPR4 interactions 1.694E-3 1.719E-2
1.099E-1
5.674E-1
 1 6
33 int:MAMDC2 MAMDC2 interactions 1.694E-3 1.719E-2
1.099E-1
5.674E-1
 1 6
34 int:EIF4E3 EIF4E3 interactions 1.976E-3 1.947E-2
1.244E-1
6.619E-1
 1 7
35 int:UBE3A UBE3A interactions 2.040E-3 1.952E-2
1.248E-1
6.833E-1
 2 257
36 int:RAD21 RAD21 interactions 2.298E-3 2.096E-2
1.340E-1
7.698E-1
 2 273
37 int:SPDL1 SPDL1 interactions 2.314E-3 2.096E-2
1.340E-1
7.753E-1
 2 274
38 int:UNK UNK interactions 2.731E-3 2.408E-2
1.539E-1
9.149E-1
 2 298
39 int:HTRA4 HTRA4 interactions 3.103E-3 2.666E-2
1.704E-1
1.000E0
 1 11
40 int:TRIM14 TRIM14 interactions 3.519E-3 2.925E-2
1.870E-1
1.000E0
 2 339
41 int:PDSS2 PDSS2 interactions 3.667E-3 2.925E-2
1.870E-1
1.000E0
 1 13
42 int:TGM5 TGM5 interactions 3.667E-3 2.925E-2
1.870E-1
1.000E0
 1 13
43 int:ZNF598 ZNF598 interactions 3.895E-3 2.939E-2
1.879E-1
1.000E0
 2 357
44 int:CAPN13 CAPN13 interactions 3.948E-3 2.939E-2
1.879E-1
1.000E0
 1 14
45 int:CCNQ CCNQ interactions 3.948E-3 2.939E-2
1.879E-1
1.000E0
 1 14
46 int:TARDBP TARDBP interactions 4.047E-3 2.947E-2
1.884E-1
1.000E0
 2 364
47 int:TMPO TMPO interactions 4.223E-3 2.952E-2
1.887E-1
1.000E0
 2 372
48 int:GCHFR GCHFR interactions 4.230E-3 2.952E-2
1.887E-1
1.000E0
 1 15
49 int:ZC3H7B ZC3H7B interactions 4.793E-3 3.277E-2
2.095E-1
1.000E0
 1 17
50 int:EIF4EBP2 EIF4EBP2 interactions 5.074E-3 3.400E-2
2.173E-1
1.000E0
 1 18
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q27 3q27 3.601E-3 7.017E-3 1.602E-2 1.801E-2 1 25
2 5q31.3 5q31.3 5.183E-3 7.017E-3 1.602E-2 2.591E-2 1 36
3 17p13 17p13 5.326E-3 7.017E-3 1.602E-2 2.663E-2 1 37
4 1p36.12 1p36.12 5.614E-3 7.017E-3 1.602E-2 2.807E-2 1 39
5 2q37.1 2q37.1 9.771E-3 9.771E-3 2.231E-2 4.886E-2 1 68

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 97 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 672 Parkinson disease associated genes|Ubiquitin C-terminal hydrolases genenames.org 1.758E-3 3.516E-3 5.274E-3 3.516E-3 1 16
2 499 DEAD-box helicases genenames.org 4.612E-3 4.612E-3 6.918E-3 9.223E-3 1 42

13: Coexpression [Display Chart] 5 input genes in category / 471 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17638893-SuppTable8 Human Breast Larsson07 24genes GeneSigDB 5.709E-6 1.479E-3 9.962E-3 2.689E-3 2 18
2 M8305 Genes up-regulated in activated T cells: CD4 [GeneID=920] versus Va24- NKT. MSigDB C7: Immunologic Signatures (v6.0) 6.282E-6 1.479E-3 9.962E-3 2.959E-3 3 200
3 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v6.0) 2.342E-4 2.459E-2
1.656E-1
1.103E-1
 2 113
4 M18086 'Cancer prone response profile' (CPRP): genes common to estradiol and bisphenol A [PubChem=5757;6623] response of epithelial cell cultures from patients at high risk of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.553E-4 2.459E-2
1.656E-1
1.203E-1
 2 118
5 M6324 Genes down-regulated in untreated spleen: DUSP1 [GeneID=1843] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 5.732E-4 2.459E-2
1.656E-1
2.700E-1
 2 177
6 M6089 Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by TGFB1 and IL4 [GeneID=7040;3565] (48h). MSigDB C7: Immunologic Signatures (v6.0) 7.164E-4 2.459E-2
1.656E-1
3.374E-1
 2 198
7 M9701 Genes down-regulated in macrophage differentiated by: CSF1 [GeneID=1435] versus CSF1 [GeneID=1435] and IL27 [GeneID=246778]. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.459E-2
1.656E-1
3.408E-1
 2 199
8 M5972 Genes down-regulated in liver: IFNG [GeneID=3458] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
9 M7789 Genes up-regulated in neutrophils: untreated versus stimulated by CSF2 and IFNG [GeneID=1437;3458]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
10 M9047 Genes up-regulated in T reg: wildtype versus ADORA2A [GeneID=135]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
11 M8297 Genes down-regulated in B lymphocytes from: peritoneal cavity versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
12 M4467 Genes down-regulated in comparison of neutrophils versusl monocytes. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
13 M4977 Genes down-regulated in comparison of monocytes from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
14 M8330 Genes down-regulated in naïve CD4 [GeneID=920] Tcells versus T conv cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.459E-2
1.656E-1
3.442E-1
 2 200
15 16424041-SuppTable2 Human Brain Lu06 285genes GeneSigDB 1.221E-3 3.833E-2
2.581E-1
5.750E-1
 2 259
16 M2292 Genes down-regulated in HSA/c and KYSE140 cells (esophageal squamous cell carcinoma, ESCC) after knockdown of PTTG1 [GeneID=9232] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.944E-3 4.965E-2
3.343E-1
9.154E-1
 1 9
17 M14105 Genes down-regulated in fibroblasts expressing the XP/CS mutant form of ERCC3 [GeneID=2071], after low dose UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.944E-3 4.965E-2
3.343E-1
9.154E-1
 1 9
18 16467079-Table3b Human HeadandNeck Slebos06 17genes GeneSigDB 2.591E-3 4.965E-2
3.343E-1
1.000E0
 1 12
19 M19652 Genes specifically up-regulated in pediadric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.806E-3 4.965E-2
3.343E-1
1.000E0
 1 13
20 15231654-Table3 Human Kidney Myers04 21genes GeneSigDB 4.100E-3 4.965E-2
3.343E-1
1.000E0
 1 19
21 18451147-Table3 Human Esophagus Ito08 22genes GeneSigDB 4.530E-3 4.965E-2
3.343E-1
1.000E0
 1 21
22 M3256 Genes changed in the B cell chronic lymphocytic leukemia (B-CLL) with deletions in the 17p13 region. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.965E-2
3.343E-1
1.000E0
 1 21
23 18714348-Table2 Human Breast Martin08 22genes GeneSigDB 4.530E-3 4.965E-2
3.343E-1
1.000E0
 1 21
24 M13202 Genes down-regulated late in HMEC cells (mammary epithelium) during acinar development in vitro. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.965E-2
3.343E-1
1.000E0
 1 21
25 M11403 Primary down-regulated targets of TP53 [GeneID=7157] in the H1299 (lung cancer) cell line. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.965E-2
3.343E-1
1.000E0
 1 21
26 19930681-Table2-2 Human Breast Cecco09 24genes GeneSigDB 4.746E-3 4.965E-2
3.343E-1
1.000E0
 1 22
27 M16374 Genes down-regulated during transition from G1 (well differentiated tumor, infected with HCV) to G2 (moderately differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.391E-3 4.965E-2
3.343E-1
1.000E0
 1 25
28 17069663-Table2 Human Breast Hannemann06 35genes DCIS v IBC GeneSigDB 5.607E-3 4.965E-2
3.343E-1
1.000E0
 1 26
29 16203770-Table3 Human Prostate Best05 28genes GeneSigDB 6.037E-3 4.965E-2
3.343E-1
1.000E0
 1 28
30 M15501 Up-regulated in CD4+ [GeneID=920] T lymphocytes after 4 h treatment with 100 nM TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.037E-3 4.965E-2
3.343E-1
1.000E0
 1 28
31 17786710-Table2 Human Lymphoma Uyttebroeck07 52genes GeneSigDB 6.037E-3 4.965E-2
3.343E-1
1.000E0
 1 28
32 M16789 Cluster 3: genes strongly up-regulated in B493-6 cells (B lymphocytes) by a combination of MYC [GeneID=4609] and serum but not by each of them alone. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.897E-3 4.965E-2
3.343E-1
1.000E0
 1 32
33 12082545-Table2b Human Uterine Kitahara02 50genes GeneSigDB 7.327E-3 4.965E-2
3.343E-1
1.000E0
 1 34
34 M13327 Genes down-regulated in uterine fibroids with deletions in the 7q region vs those without the deletion. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.756E-3 4.965E-2
3.343E-1
1.000E0
 1 36
35 M1801 Up-regulated genes from the set D (Fig. 5a): specific signature shared by cells expressing MLL-AF4 [GeneID=4297;4299] alone and those expressing both MLL-AF4 and AF4-MLL fusion proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.186E-3 4.965E-2
3.343E-1
1.000E0
 1 38
36 12917207-TableS5 Human Colon Glebov03 87genes GeneSigDB 8.400E-3 4.965E-2
3.343E-1
1.000E0
 1 39
37 15843827-TableS9 Human Leukemia Andersson05 50genes GeneSigDB 8.615E-3 4.965E-2
3.343E-1
1.000E0
 1 40
38 17429429-Table2 Mouse Leukemia Lin07 57genes SCL-LMO1T-cellTumors GeneSigDB 8.615E-3 4.965E-2
3.343E-1
1.000E0
 1 40
39 14581339-SuppTable6 Human Lung Yamagata03 54genes GeneSigDB 8.615E-3 4.965E-2
3.343E-1
1.000E0
 1 40
40 M19148 Genes up-regulated in prostate cancer vs benign prostate tissue, based on a meta-analysis of five gene expression profiling studies. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.615E-3 4.965E-2
3.343E-1
1.000E0
 1 40
41 15817677-TableS2c Human Leukemia Falt05 50genes UpRegulatedVH3a GeneSigDB 8.830E-3 4.965E-2
3.343E-1
1.000E0
 1 41
42 M14940 Genes down-regulated in B-CLL (B-cell chronic leukemia) samples expressing high levels of LPL [GeneID=4023] compared with those expressing low levels of the gene. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.044E-3 4.965E-2
3.343E-1
1.000E0
 1 42
43 15572690-SuppTable5b Mouse Leukemia Walter04 62genes b GeneSigDB 9.044E-3 4.965E-2
3.343E-1
1.000E0
 1 42
44 15608061-Table1 Human Breast Zucchi04 50genes down-regulated INV MET GeneSigDB 9.044E-3 4.965E-2
3.343E-1
1.000E0
 1 42
45 M3782 Genes down-regulated in ST1 cells (adult T-cell leukemia, ATL) after knockdown of FRA2 [GeneID=2355] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.965E-2
3.343E-1
1.000E0
 1 43
46 M2377 Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-133 microRNA. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.965E-2
3.343E-1
1.000E0
 1 43
47 M15164 Genes up-regulated in samples from B-CLL (B-cell chronic lymphocytic leukemia) with the immunoglobulin heavy chain VH3-21 gene. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.473E-3 4.965E-2
3.343E-1
1.000E0
 1 44
48 M16826 The 50 most down-regulated genes in primary invasive breast dutcal carcinoma (IDC) or lymph node metastases, compared to normal mammary epithelium. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.473E-3 4.965E-2
3.343E-1
1.000E0
 1 44
49 15817677-TableS1b Human Leukemia Falt05 50genes UpRegulatedVH3 GeneSigDB 9.902E-3 4.965E-2
3.343E-1
1.000E0
 1 46
50 16886892-Table2 Human Breast Chalabi06 57genes GeneSigDB 9.902E-3 4.965E-2
3.343E-1
1.000E0
 1 46
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 241 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 3 input genes in category / 48 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8114 MODULE 81 Genes in the cancer module 81. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.130E-5 5.426E-4 2.419E-3 5.426E-4 2 20
2 M18002 MORF CSNK2B Neighborhood of CSNK2B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.314E-5 5.554E-4 2.477E-3 1.111E-3 3 287
3 M12287 MORF SKP1A Neighborhood of SKP1A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.193E-3 1.651E-2
7.362E-2
5.727E-2
 2 202
4 M2967 MORF AP2M1 Neighborhood of AP2M1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.376E-3 1.651E-2
7.362E-2
6.605E-2
 2 217

16: MicroRNA [Display Chart] 5 input genes in category / 177 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3126-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.291E-5 2.027E-3 1.167E-2 4.054E-3 2 110
2 hsa-miR-6875-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.291E-5 2.027E-3 1.167E-2 4.054E-3 2 110
3 hsa-miR-455-3p.2:TargetScan hsa-miR-455-3p.2 TargetScan 1.166E-4 6.878E-3 3.959E-2 2.063E-2 2 248
4 hsa-miR-718:mirSVR lowEffct hsa-miR-718:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.891E-4 7.123E-3 4.100E-2 3.347E-2 2 316
5 hsa-miR-212-5p:TargetScan hsa-miR-212-5p TargetScan 2.012E-4 7.123E-3 4.100E-2 3.561E-2 2 326
6 hsa-miR-744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.591E-4 1.059E-2
6.097E-2
6.356E-2
 2 436
7 CGCTGCT,MIR-503:MSigDB CGCTGCT,MIR-503:MSigDB MSigDB 1.314E-3 2.694E-2
1.550E-1
2.326E-1
 1 19
8 hsa-miR-6770-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.384E-3 2.694E-2
1.550E-1
2.449E-1
 1 20
9 hsa-miR-566:PITA hsa-miR-566:PITA TOP PITA 1.384E-3 2.694E-2
1.550E-1
2.449E-1
 1 20
10 hsa-miR-611:PITA hsa-miR-611:PITA TOP PITA 1.522E-3 2.694E-2
1.550E-1
2.694E-1
 1 22
11 hsa-miR-3200-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.351E-3 2.855E-2
1.643E-1
4.161E-1
 1 34
12 hsa-miR-4724-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.973E-3 2.855E-2
1.643E-1
5.262E-1
 1 43
13 hsa-miR-517c:PITA hsa-miR-517c:PITA TOP PITA 3.042E-3 2.855E-2
1.643E-1
5.384E-1
 1 44
14 hsa-miR-517a:PITA hsa-miR-517a:PITA TOP PITA 3.042E-3 2.855E-2
1.643E-1
5.384E-1
 1 44
15 hsa-miR-3613-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.249E-3 2.855E-2
1.643E-1
5.750E-1
 1 47
16 hsa-miR-1284:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 2.855E-2
1.643E-1
5.995E-1
 1 49
17 hsa-miR-601:PITA hsa-miR-601:PITA TOP PITA 4.008E-3 2.855E-2
1.643E-1
7.094E-1
 1 58
18 hsa-miR-3189-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.215E-3 2.855E-2
1.643E-1
7.460E-1
 1 61
19 hsa-miR-4758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.491E-3 2.855E-2
1.643E-1
7.949E-1
 1 65
20 hsa-miR-4467:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.698E-3 2.855E-2
1.643E-1
8.315E-1
 1 68
21 hsa-miR-6813-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.698E-3 2.855E-2
1.643E-1
8.315E-1
 1 68
22 ACAACTT,MIR-382:MSigDB ACAACTT,MIR-382:MSigDB MSigDB 4.767E-3 2.855E-2
1.643E-1
8.437E-1
 1 69
23 hsa-miR-503:PITA hsa-miR-503:PITA TOP PITA 4.836E-3 2.855E-2
1.643E-1
8.559E-1
 1 70
24 hsa-miR-5699-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.836E-3 2.855E-2
1.643E-1
8.559E-1
 1 70
25 AAGGGAT,MIR-188:MSigDB AAGGGAT,MIR-188:MSigDB MSigDB 4.905E-3 2.855E-2
1.643E-1
8.681E-1
 1 71
26 hsa-miR-1293:PITA hsa-miR-1293:PITA TOP PITA 5.111E-3 2.855E-2
1.643E-1
9.047E-1
 1 74
27 hsa-miR-885-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.318E-3 2.855E-2
1.643E-1
9.413E-1
 1 77
28 ATGTCAC,MIR-489:MSigDB ATGTCAC,MIR-489:MSigDB MSigDB 5.801E-3 2.855E-2
1.643E-1
1.000E0
 1 84
29 GGCAGTG,MIR-324-3P:MSigDB GGCAGTG,MIR-324-3P:MSigDB MSigDB 6.007E-3 2.855E-2
1.643E-1
1.000E0
 1 87
30 hsa-miR-493-3p:Functional MTI Functional MTI miRTarbase 6.076E-3 2.855E-2
1.643E-1
1.000E0
 1 88
31 hsa-miR-4802-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.214E-3 2.855E-2
1.643E-1
1.000E0
 1 90
32 hsa-miR-4519:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.352E-3 2.855E-2
1.643E-1
1.000E0
 1 92
33 hsa-miR-7845-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.765E-3 2.855E-2
1.643E-1
1.000E0
 1 98
34 hsa-miR-6834-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.902E-3 2.855E-2
1.643E-1
1.000E0
 1 100
35 ACTGCAG,MIR-17-3P:MSigDB ACTGCAG,MIR-17-3P:MSigDB MSigDB 6.902E-3 2.855E-2
1.643E-1
1.000E0
 1 100
36 GGTGTGT,MIR-329:MSigDB GGTGTGT,MIR-329:MSigDB MSigDB 7.109E-3 2.855E-2
1.643E-1
1.000E0
 1 103
37 hsa-miR-543:Functional MTI Functional MTI miRTarbase 7.384E-3 2.855E-2
1.643E-1
1.000E0
 1 107
38 hsa-miR-3674:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.453E-3 2.855E-2
1.643E-1
1.000E0
 1 108
39 hsa-miR-935:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.278E-3 2.855E-2
1.643E-1
1.000E0
 1 120
40 hsa-miR-6798-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.278E-3 2.855E-2
1.643E-1
1.000E0
 1 120
41 hsa-miR-7109-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.553E-3 2.855E-2
1.643E-1
1.000E0
 1 124
42 hsa-miR-493-3p:TargetScan hsa-miR-493-3p TargetScan 8.691E-3 2.855E-2
1.643E-1
1.000E0
 1 126
43 hsa-miR-623:PITA hsa-miR-623:PITA TOP PITA 8.897E-3 2.855E-2
1.643E-1
1.000E0
 1 129
44 hsa-miR-1245:PITA hsa-miR-1245:PITA TOP PITA 9.103E-3 2.855E-2
1.643E-1
1.000E0
 1 132
45 hsa-miR-1268:mirSVR highEffct hsa-miR-1268:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.172E-3 2.855E-2
1.643E-1
1.000E0
 1 133
46 hsa-miR-608:PITA hsa-miR-608:PITA TOP PITA 9.309E-3 2.855E-2
1.643E-1
1.000E0
 1 135
47 hsa-miR-1238-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.309E-3 2.855E-2
1.643E-1
1.000E0
 1 135
48 hsa-miR-770-5p:PITA hsa-miR-770-5p:PITA TOP PITA 9.378E-3 2.855E-2
1.643E-1
1.000E0
 1 136
49 hsa-miR-6765-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.378E-3 2.855E-2
1.643E-1
1.000E0
 1 136
50 hsa-miR-1266:PITA hsa-miR-1266:PITA TOP PITA 9.447E-3 2.855E-2
1.643E-1
1.000E0
 1 137
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 483 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000122035 AC1Q6S1Y Stitch 1.776E-12 8.577E-10 5.797E-9 8.577E-10 5 104
2 CID000001896 AC1L1CH3 Stitch 8.904E-10 1.809E-7 1.222E-6 4.301E-7 4 85
3 CID000414014 NSC99363 Stitch 1.123E-9 1.809E-7 1.222E-6 5.426E-7 4 90
4 CID000446000 AC1L9IXX Stitch 7.126E-8 8.605E-6 5.815E-5 3.442E-5 3 45
5 CID000125643 UDP-FGlc Stitch 1.897E-7 1.833E-5 1.239E-4 9.163E-5 3 62
6 CID000008420 2-naphthalenesulfonate Stitch 6.287E-7 5.061E-5 3.420E-4 3.037E-4 3 92
7 CID000072981 palinavir Stitch 8.047E-7 5.553E-5 3.753E-4 3.887E-4 2 7
8 CID000446186 1i32 Stitch 1.745E-6 1.054E-4 7.122E-4 8.431E-4 3 129
9 CID000004265 AC1L1HRY Stitch 3.781E-5 2.029E-3 1.371E-2 1.826E-2 2 45
10 CID000003324 famciclovir Stitch 5.061E-5 2.445E-3 1.652E-2 2.445E-2 2 52
11 CID000447945 AC1L9LF4 Stitch 7.687E-5 3.375E-3 2.281E-2 3.713E-2 2 64
12 CID000439298 poly (A Stitch 1.057E-4 4.255E-3 2.875E-2
5.106E-2
 2 75
13 CID000121958 m(7)GpppG Stitch 3.845E-4 1.322E-2
8.931E-2
1.857E-1
 2 143
14 CID000004330 ICE inhibitor Stitch 4.007E-4 1.322E-2
8.931E-2
1.935E-1
 2 146
15 ctd:C017516 7-methylguanosine triphosphate CTD 4.378E-4 1.322E-2
8.931E-2
2.114E-1
 1 2
16 CID000100136 N-Formyl-Met-Val Stitch 4.378E-4 1.322E-2
8.931E-2
2.114E-1
 1 2
17 985 DN ICI 182,780; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 5.880E-4 1.348E-2
9.113E-2
2.840E-1
 2 177
18 3998 DN Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.947E-4 1.348E-2
9.113E-2
2.872E-1
 2 178
19 ctd:D011748 Pyrogallol CTD 6.013E-4 1.348E-2
9.113E-2
2.904E-1
 2 179
20 4585 DN Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 6.013E-4 1.348E-2
9.113E-2
2.904E-1
 2 179
21 5310 DN Puromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 6.080E-4 1.348E-2
9.113E-2
2.937E-1
 2 180
22 1043 DN ICI 182,780; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 6.216E-4 1.348E-2
9.113E-2
3.002E-1
 2 182
23 6735 DN Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 6.630E-4 1.348E-2
9.113E-2
3.202E-1
 2 188
24 1045 DN Rapamycin; Down 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 6.700E-4 1.348E-2
9.113E-2
3.236E-1
 2 189
25 3431 DN Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.057E-4 1.363E-2
9.215E-2
3.409E-1
 2 194
26 CID000001652 3-deazacytidine Stitch 7.951E-4 1.477E-2
9.983E-2
3.840E-1
 2 206
27 ctd:C421324 pateamine A CTD 1.313E-3 2.349E-2
1.587E-1
6.341E-1
 1 6
28 CID000452638 CP-77 Stitch 1.969E-3 3.396E-2
2.295E-1
9.509E-1
 1 9
29 CID000000544 arsenite Stitch 2.233E-3 3.719E-2
2.513E-1
1.000E0
 2 347
30 ctd:C546012 N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide CTD 2.624E-3 4.225E-2
2.855E-1
1.000E0
 1 12
31 CID000008542 AC1L1R7G Stitch 2.843E-3 4.429E-2
2.993E-1
1.000E0
 1 13
32 ctd:C553294 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one CTD 3.061E-3 4.518E-2
3.053E-1
1.000E0
 1 14
33 CID000430167 2-amino-4-chloro-6-hydroxy-s-triazine Stitch 3.498E-3 4.518E-2
3.053E-1
1.000E0
 1 16
34 CID000414699 AC1MW7VF Stitch 4.153E-3 4.518E-2
3.053E-1
1.000E0
 1 19
35 CID000007327 DPBs Stitch 4.153E-3 4.518E-2
3.053E-1
1.000E0
 1 19
36 CID005351257 NSC178249 Stitch 4.589E-3 4.518E-2
3.053E-1
1.000E0
 1 21
37 CID000008927 elaidyl alcohol Stitch 5.025E-3 4.518E-2
3.053E-1
1.000E0
 1 23
38 CID000010583 elemene Stitch 5.679E-3 4.518E-2
3.053E-1
1.000E0
 1 26
39 CID005159169 AC1NPJ0W Stitch 5.679E-3 4.518E-2
3.053E-1
1.000E0
 1 26
40 ctd:C573233 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one CTD 5.679E-3 4.518E-2
3.053E-1
1.000E0
 1 26
41 ctd:D000068338 Everolimus CTD 5.897E-3 4.518E-2
3.053E-1
1.000E0
 1 27
42 CID000213100 S 30 Stitch 6.550E-3 4.518E-2
3.053E-1
1.000E0
 1 30
43 CID011644425 CGP57380 Stitch 6.768E-3 4.518E-2
3.053E-1
1.000E0
 1 31
44 CID000462147 AC1LA5IX Stitch 6.768E-3 4.518E-2
3.053E-1
1.000E0
 1 31
45 CID000004526 AC1Q5ZRG Stitch 7.856E-3 4.518E-2
3.053E-1
1.000E0
 1 36
46 CID000004987 K00014 Stitch 8.291E-3 4.518E-2
3.053E-1
1.000E0
 1 38
47 CID000003295 ethoxzolamide Stitch 8.726E-3 4.518E-2
3.053E-1
1.000E0
 1 40
48 CID005289515 U-U-U Stitch 8.944E-3 4.518E-2
3.053E-1
1.000E0
 1 41
49 CID000166290 Antibiotic Ps 6 Stitch 8.944E-3 4.518E-2
3.053E-1
1.000E0
 1 41
50 ctd:C018511 4-dichlorobenzene CTD 1.155E-2 4.518E-2
3.053E-1
1.000E0
 1 53
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 31 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0276447 Rhinovirus infection DisGeNET BeFree 7.840E-5 2.431E-3 9.788E-3 2.431E-3 2 46
2 C3280271 PARKINSON DISEASE 18 DisGeNET Curated 3.085E-4 3.188E-3 1.284E-2 9.565E-3 1 1
3 cv:C3280271 Parkinson disease 18 Clinical Variations 3.085E-4 3.188E-3 1.284E-2 9.565E-3 1 1
4 C0206617 Cardiovirus Infections DisGeNET Curated 9.254E-4 7.172E-3 2.888E-2 2.869E-2 1 3
5 C0393590 Fahr's syndrome (disorder) DisGeNET Curated 1.850E-3 1.147E-2 4.620E-2
5.735E-2
 1 6
6 C0752098 Autosomal Dominant Parkinsonism DisGeNET BeFree 3.082E-3 1.314E-2
5.290E-2
9.554E-2
 1 10
7 C4274355 Autosomal dominant late onset Parkinson disease DisGeNET Curated 3.082E-3 1.314E-2
5.290E-2
9.554E-2
 1 10
8 C0153653 Malignant tumor of parathyroid gland DisGeNET BeFree 3.390E-3 1.314E-2
5.290E-2
1.051E-1
 1 11
9 C0687150 Parathyroid Gland Adenocarcinoma DisGeNET Curated 9.836E-3 3.144E-2
1.266E-1
3.049E-1
 1 32
10 C3489791 Parkinson Disease, Familial, Type 1 DisGeNET BeFree 1.014E-2 3.144E-2
1.266E-1
3.144E-1
 1 33
11 C1332225 Aggressive Non-Hodgkin Lymphoma DisGeNET BeFree 1.167E-2 3.289E-2
1.325E-1
3.618E-1
 1 38
12 C0025268 Multiple Endocrine Neoplasia Type 2a DisGeNET Curated 1.838E-2 4.748E-2
1.912E-1
5.697E-1
 1 60
Show 7 more annotations