Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc32_14, positive side

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1: GO: Molecular Function [Display Chart] 14 input genes in category / 58 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003924 GTPase activity 2.260E-5 1.311E-3 6.089E-3 1.311E-3 4 236
2 GO:0017016 Ras GTPase binding 1.087E-3 2.164E-2
1.005E-1
6.306E-2
 3 281
3 GO:0031267 small GTPase binding 1.325E-3 2.164E-2
1.005E-1
7.688E-2
 3 301
4 GO:0051020 GTPase binding 1.681E-3 2.164E-2
1.005E-1
9.752E-2
 3 327
5 GO:0060589 nucleoside-triphosphatase regulator activity 1.944E-3 2.164E-2
1.005E-1
1.127E-1
 3 344
6 GO:0005525 GTP binding 2.542E-3 2.164E-2
1.005E-1
1.474E-1
 3 378
7 GO:0032561 guanyl ribonucleotide binding 2.963E-3 2.164E-2
1.005E-1
1.719E-1
 3 399
8 GO:0019001 guanyl nucleotide binding 2.984E-3 2.164E-2
1.005E-1
1.731E-1
 3 400
9 GO:0017034 Rap guanyl-nucleotide exchange factor activity 3.746E-3 2.414E-2
1.122E-1
2.173E-1
 1 5
10 GO:0008046 axon guidance receptor activity 5.987E-3 3.473E-2
1.613E-1
3.473E-1
 1 8
11 GO:0005005 transmembrane-ephrin receptor activity 7.479E-3 3.556E-2
1.652E-1
4.338E-1
 1 10
12 GO:0000774 adenyl-nucleotide exchange factor activity 7.479E-3 3.556E-2
1.652E-1
4.338E-1
 1 10
13 GO:0004713 protein tyrosine kinase activity 7.970E-3 3.556E-2
1.652E-1
4.623E-1
 2 182
14 GO:0070410 co-SMAD binding 8.968E-3 3.715E-2
1.726E-1
5.202E-1
 1 12
15 GO:0008022 protein C-terminus binding 1.187E-2 4.590E-2
2.133E-1
6.885E-1
 2 224
16 GO:0005088 Ras guanyl-nucleotide exchange factor activity 1.269E-2 4.601E-2
2.138E-1
7.361E-1
 2 232
17 GO:0005003 ephrin receptor activity 1.417E-2 4.803E-2
2.232E-1
8.216E-1
 1 19
18 GO:0070064 proline-rich region binding 1.491E-2 4.803E-2
2.232E-1
8.645E-1
 1 20
Show 13 more annotations

2: GO: Biological Process [Display Chart] 14 input genes in category / 593 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030031 cell projection assembly 4.075E-7 2.417E-4 1.683E-3 2.417E-4 6 436
2 GO:0030033 microvillus assembly 8.704E-7 2.581E-4 1.797E-3 5.161E-4 3 26
3 GO:0032528 microvillus organization 1.656E-6 3.273E-4 2.279E-3 9.820E-4 3 32
4 GO:0007265 Ras protein signal transduction 3.111E-6 4.612E-4 3.211E-3 1.845E-3 5 333
5 GO:0061028 establishment of endothelial barrier 4.100E-6 4.863E-4 3.386E-3 2.432E-3 3 43
6 GO:0050766 positive regulation of phagocytosis 1.072E-5 8.804E-4 6.130E-3 6.360E-3 3 59
7 GO:1900029 positive regulation of ruffle assembly 1.100E-5 8.804E-4 6.130E-3 6.521E-3 2 7
8 GO:0034329 cell junction assembly 1.188E-5 8.804E-4 6.130E-3 7.043E-3 4 200
9 GO:0001885 endothelial cell development 1.371E-5 9.037E-4 6.292E-3 8.133E-3 3 64
10 GO:0034330 cell junction organization 3.230E-5 1.704E-3 1.187E-2 1.915E-2 4 258
11 GO:0050764 regulation of phagocytosis 3.336E-5 1.704E-3 1.187E-2 1.978E-2 3 86
12 GO:0090557 establishment of endothelial intestinal barrier 3.449E-5 1.704E-3 1.187E-2 2.045E-2 2 12
13 GO:0031532 actin cytoskeleton reorganization 3.823E-5 1.726E-3 1.202E-2 2.267E-2 3 90
14 GO:0032486 Rap protein signal transduction 4.074E-5 1.726E-3 1.202E-2 2.416E-2 2 13
15 GO:0051056 regulation of small GTPase mediated signal transduction 5.448E-5 2.154E-3 1.500E-2 3.231E-2 4 295
16 GO:0045446 endothelial cell differentiation 6.774E-5 2.511E-3 1.748E-2 4.017E-2 3 109
17 GO:0003158 endothelium development 1.118E-4 3.899E-3 2.715E-2
6.628E-2
 3 129
18 GO:1900027 regulation of ruffle assembly 1.202E-4 3.905E-3 2.719E-2
7.127E-2
 2 22
19 GO:0045807 positive regulation of endocytosis 1.251E-4 3.905E-3 2.719E-2
7.419E-2
 3 134
20 GO:1903306 negative regulation of regulated secretory pathway 1.688E-4 5.005E-3 3.485E-2
1.001E-1
 2 26
21 GO:0031032 actomyosin structure organization 2.192E-4 6.190E-3 4.310E-2
1.300E-1
 3 162
22 GO:0097178 ruffle assembly 2.410E-4 6.349E-3 4.421E-2
1.429E-1
 2 31
23 GO:2000249 regulation of actin cytoskeleton reorganization 2.570E-4 6.349E-3 4.421E-2
1.524E-1
 2 32
24 GO:0045920 negative regulation of exocytosis 2.570E-4 6.349E-3 4.421E-2
1.524E-1
 2 32
25 GO:0060491 regulation of cell projection assembly 2.705E-4 6.417E-3 4.468E-2
1.604E-1
 3 174
26 GO:0046578 regulation of Ras protein signal transduction 4.070E-4 9.283E-3
6.464E-2
2.414E-1
 3 200
27 GO:0034260 negative regulation of GTPase activity 4.876E-4 1.013E-2
7.055E-2
2.891E-1
 2 44
28 GO:0031529 ruffle organization 5.330E-4 1.013E-2
7.055E-2
3.161E-1
 2 46
29 GO:0046326 positive regulation of glucose import 5.564E-4 1.013E-2
7.055E-2
3.300E-1
 2 47
30 GO:0072659 protein localization to plasma membrane 5.741E-4 1.013E-2
7.055E-2
3.404E-1
 3 225
31 GO:0030100 regulation of endocytosis 5.815E-4 1.013E-2
7.055E-2
3.449E-1
 3 226
32 GO:1990778 protein localization to cell periphery 5.891E-4 1.013E-2
7.055E-2
3.493E-1
 3 227
33 GO:0045216 cell-cell junction organization 6.120E-4 1.013E-2
7.055E-2
3.629E-1
 3 230
34 GO:0010828 positive regulation of glucose transmembrane transport 7.344E-4 1.013E-2
7.055E-2
4.355E-1
 2 54
35 GO:0046777 protein autophosphorylation 7.354E-4 1.013E-2
7.055E-2
4.361E-1
 3 245
36 GO:0002064 epithelial cell development 7.442E-4 1.013E-2
7.055E-2
4.413E-1
 3 246
37 GO:1904441 regulation of thyroid gland epithelial cell proliferation 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
38 GO:1990789 thyroid gland epithelial cell proliferation 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
39 GO:1990792 cellular response to glial cell derived neurotrophic factor 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
40 GO:1990790 response to glial cell derived neurotrophic factor 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
41 GO:1903697 negative regulation of microvillus assembly 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
42 GO:0097327 response to antineoplastic agent 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
43 GO:1901350 cell-cell signaling involved in cell-cell junction organization 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
44 GO:1904442 negative regulation of thyroid gland epithelial cell proliferation 7.518E-4 1.013E-2
7.055E-2
4.458E-1
 1 1
45 GO:0006909 phagocytosis 8.259E-4 1.088E-2
7.579E-2
4.898E-1
 3 255
46 GO:0007009 plasma membrane organization 1.210E-3 1.559E-2
1.086E-1
7.174E-1
 3 291
47 GO:0032956 regulation of actin cytoskeleton organization 1.346E-3 1.698E-2
1.183E-1
7.982E-1
 3 302
48 GO:0046324 regulation of glucose import 1.411E-3 1.744E-2
1.214E-1
8.369E-1
 2 75
49 GO:1904425 negative regulation of GTP binding 1.503E-3 1.774E-2
1.235E-1
8.913E-1
 1 2
50 GO:0043314 negative regulation of neutrophil degranulation 1.503E-3 1.774E-2
1.235E-1
8.913E-1
 1 2
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 14 input genes in category / 73 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005913 cell-cell adherens junction 1.537E-5 1.122E-3 5.469E-3 1.122E-3 3 68
2 GO:0043296 apical junction complex 1.093E-4 3.988E-3 1.944E-2 7.976E-3 3 131
3 GO:0005911 cell-cell junction 1.917E-4 4.664E-3 2.273E-2 1.399E-2 4 418
4 GO:0005912 adherens junction 3.357E-4 6.126E-3 2.986E-2 2.450E-2 4 484
5 GO:0005899 insulin receptor complex 2.202E-3 3.215E-2
1.567E-1
1.607E-1
 1 3
6 GO:0005923 bicellular tight junction 3.132E-3 3.435E-2
1.674E-1
2.286E-1
 2 115
7 GO:0070160 tight junction 3.294E-3 3.435E-2
1.674E-1
2.405E-1
 2 118
8 GO:0055037 recycling endosome 4.600E-3 3.702E-2
1.804E-1
3.358E-1
 2 140
9 GO:0036056 filtration diaphragm 5.862E-3 3.702E-2
1.804E-1
4.279E-1
 1 8
10 GO:0036057 slit diaphragm 5.862E-3 3.702E-2
1.804E-1
4.279E-1
 1 8
11 GO:0032045 guanyl-nucleotide exchange factor complex 6.592E-3 3.702E-2
1.804E-1
4.812E-1
 1 9
12 GO:0046581 intercellular canaliculus 6.592E-3 3.702E-2
1.804E-1
4.812E-1
 1 9
13 GO:0005915 zonula adherens 6.592E-3 3.702E-2
1.804E-1
4.812E-1
 1 9
14 GO:0016600 flotillin complex 8.052E-3 4.198E-2
2.047E-1
5.878E-1
 1 11
Show 9 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 1129 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 12 input genes in category / 485 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000260 abnormal angiogenesis 7.092E-5 3.440E-2
2.326E-1
 3.440E-2 5 425
2 MP:0005602 decreased angiogenesis 1.752E-4 4.248E-2
2.873E-1
8.496E-2
 3 99

6: Domain [Display Chart] 14 input genes in category / 146 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS51421 RAS PROSITE 2.144E-6 1.856E-4 1.033E-3 3.130E-4 3 35
2 IPR020849 Small GTPase Ras InterPro 2.543E-6 1.856E-4 1.033E-3 3.712E-4 3 37
3 PF00071 Ras Pfam 1.284E-4 6.251E-3 3.478E-2 1.875E-2 3 136
4 IPR001806 Small GTPase InterPro 2.076E-4 6.878E-3 3.827E-2 3.032E-2 3 160
5 IPR005225 Small GTP-bd dom InterPro 2.356E-4 6.878E-3 3.827E-2 3.439E-2 3 167
6 4.10.280.30 - Gene3D 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
7 IPR033633 RASSF9 InterPro 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
8 IPR021622 Afadin/alpha-actinin-bd InterPro 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
9 IPR005418 ZO-1 InterPro 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
10 PF09036 Bcr-Abl Oligo Pfam 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
11 PF11559 ADIP Pfam 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
12 IPR015123 Bcr-Abl oncoprot oligo InterPro 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
13 IPR028506 CAP/ponsin InterPro 7.473E-4 8.392E-3 4.670E-2
1.091E-1
 1 1
14 IPR027310 Profilin CS InterPro 1.494E-3 1.487E-2
8.272E-2
2.181E-1
 1 2
15 PF07653 SH3 2 Pfam 1.871E-3 1.487E-2
8.272E-2
2.731E-1
 2 87
16 IPR011511 SH3 2 InterPro 1.871E-3 1.487E-2
8.272E-2
2.731E-1
 2 87
17 IPR003127 SoHo dom InterPro 2.240E-3 1.487E-2
8.272E-2
3.271E-1
 1 3
18 IPR005417 ZO InterPro 2.240E-3 1.487E-2
8.272E-2
3.271E-1
 1 3
19 PF02208 Sorb Pfam 2.240E-3 1.487E-2
8.272E-2
3.271E-1
 1 3
20 PS50831 SOHO PROSITE 2.240E-3 1.487E-2
8.272E-2
3.271E-1
 1 3
21 SM00459 Sorb SMART 2.240E-3 1.487E-2
8.272E-2
3.271E-1
 1 3
22 IPR005454 Profilin1/2/3 vertebrate InterPro 2.240E-3 1.487E-2
8.272E-2
3.271E-1
 1 3
23 IPR033593 N-RASSF InterPro 2.986E-3 1.615E-2
8.984E-2
4.359E-1
 1 4
24 PF00235 Profilin Pfam 2.986E-3 1.615E-2
8.984E-2
4.359E-1
 1 4
25 IPR005455 PFN InterPro 2.986E-3 1.615E-2
8.984E-2
4.359E-1
 1 4
26 SM00392 PROF SMART 2.986E-3 1.615E-2
8.984E-2
4.359E-1
 1 4
27 PS00414 PROFILIN PROSITE 2.986E-3 1.615E-2
8.984E-2
4.359E-1
 1 4
28 PF02188 GoLoco Pfam 5.220E-3 2.458E-2
1.368E-1
7.621E-1
 1 7
29 PS50877 GOLOCO PROSITE 5.220E-3 2.458E-2
1.368E-1
7.621E-1
 1 7
30 IPR003109 GoLoco motif InterPro 5.220E-3 2.458E-2
1.368E-1
7.621E-1
 1 7
31 SM00390 GoLoco SMART 5.220E-3 2.458E-2
1.368E-1
7.621E-1
 1 7
32 SM00218 ZU5 SMART 6.707E-3 3.060E-2
1.703E-1
9.792E-1
 1 9
33 PS51145 ZU5 PROSITE 7.449E-3 3.103E-2
1.727E-1
1.000E0
 1 10
34 PF02145 Rap GAP Pfam 7.449E-3 3.103E-2
1.727E-1
1.000E0
 1 10
35 PS50085 RAPGAP PROSITE 8.191E-3 3.103E-2
1.727E-1
1.000E0
 1 11
36 IPR000331 Rap GAP dom InterPro 8.191E-3 3.103E-2
1.727E-1
1.000E0
 1 11
37 PF07699 Ephrin rec like Pfam 8.191E-3 3.103E-2
1.727E-1
1.000E0
 1 11
38 IPR000906 ZU5 dom InterPro 8.933E-3 3.103E-2
1.727E-1
1.000E0
 1 12
39 PF00791 ZU5 Pfam 8.933E-3 3.103E-2
1.727E-1
1.000E0
 1 12
40 PS51550 EPH LBD PROSITE 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
41 IPR027936 Eph TM InterPro 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
42 PS00790 RECEPTOR TYR KIN V 1 PROSITE 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
43 IPR001090 Ephrin rcpt lig-bd dom InterPro 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
44 SM00615 EPH lbd SMART 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
45 PF01404 Ephrin lbd Pfam 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
46 IPR016257 Tyr kinase ephrin rcpt InterPro 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
47 PF14575 EphA2 TM Pfam 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
48 IPR001426 Tyr kinase rcpt V CS InterPro 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
49 PS00791 RECEPTOR TYR KIN V 2 PROSITE 1.041E-2 3.103E-2
1.727E-1
1.000E0
 1 14
50 SM00326 SH3 SMART 1.109E-2 3.174E-2
1.766E-1
1.000E0
 2 217
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 344 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3342 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 7.347E-6 2.527E-3 1.622E-2 2.527E-3 3 38
2 868086 Rap1 signaling pathway BioSystems: KEGG 4.992E-5 5.835E-3 3.745E-2 1.717E-2 4 210
3 83070 Adherens junction BioSystems: KEGG 5.088E-5 5.835E-3 3.745E-2 1.750E-2 3 72
4 1269202 Rap1 signalling BioSystems: REACTOME 1.198E-4 1.030E-2
6.613E-2
 4.121E-2 2 16
5 M7897 Inhibition of Cellular Proliferation by Gleevec MSigDB C2 BIOCARTA (v6.0) 2.515E-4 1.255E-2
8.057E-2
8.652E-2
 2 23
6 M17200 Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. MSigDB C2 BIOCARTA (v6.0) 2.742E-4 1.255E-2
8.057E-2
9.433E-2
 2 24
7 M6355 Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia MSigDB C2 BIOCARTA (v6.0) 2.742E-4 1.255E-2
8.057E-2
9.433E-2
 2 24
8 138047 EPHB forward signaling BioSystems: Pathway Interaction Database 5.218E-4 1.255E-2
8.057E-2
1.795E-1
 2 33
9 SMP00320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine SMPDB 5.218E-4 1.255E-2
8.057E-2
1.795E-1
 2 33
10 138051 EPO signaling pathway BioSystems: Pathway Interaction Database 5.218E-4 1.255E-2
8.057E-2
1.795E-1
 2 33
11 SMP00321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine SMPDB 5.541E-4 1.255E-2
8.057E-2
1.906E-1
 2 34
12 1457783 Signaling by high-kinase activity BRAF mutants BioSystems: REACTOME 5.873E-4 1.255E-2
8.057E-2
2.020E-1
 2 35
13 P00034 Integrin signalling pathway PantherDB 6.141E-4 1.255E-2
8.057E-2
2.113E-1
 3 167
14 83071 Tight junction BioSystems: KEGG 6.469E-4 1.255E-2
8.057E-2
2.225E-1
 3 170
15 M19358 Signaling of Hepatocyte Growth Factor Receptor MSigDB C2 BIOCARTA (v6.0) 6.567E-4 1.255E-2
8.057E-2
2.259E-1
 2 37
16 1268864 Signaling by FGFR1 in disease BioSystems: REACTOME 6.927E-4 1.255E-2
8.057E-2
2.383E-1
 2 38
17 137915 Signaling events regulated by Ret tyrosine kinase BioSystems: Pathway Interaction Database 6.927E-4 1.255E-2
8.057E-2
2.383E-1
 2 38
18 1269287 MAP2K and MAPK activation BioSystems: REACTOME 7.297E-4 1.255E-2
8.057E-2
2.510E-1
 2 39
19 1457785 Paradoxical activation of RAF signaling by kinase inactive BRAF BioSystems: REACTOME 7.297E-4 1.255E-2
8.057E-2
2.510E-1
 2 39
20 1457784 Signaling by moderate kinase activity BRAF mutants BioSystems: REACTOME 7.297E-4 1.255E-2
8.057E-2
2.510E-1
 2 39
21 1270332 EPHB-mediated forward signaling BioSystems: REACTOME 8.464E-4 1.387E-2
8.901E-2
2.912E-1
 2 42
22 138026 Insulin Pathway BioSystems: Pathway Interaction Database 8.872E-4 1.387E-2
8.905E-2
3.052E-1
 2 43
23 1457782 Signaling by RAS mutants BioSystems: REACTOME 1.247E-3 1.865E-2
1.197E-1
4.289E-1
 2 51
24 1457786 Signaling by BRAF and RAF fusions BioSystems: REACTOME 1.779E-3 2.550E-2
1.637E-1
6.120E-1
 2 61
25 1268863 Signaling by FGFR in disease BioSystems: REACTOME 1.896E-3 2.609E-2
1.675E-1
6.523E-1
 2 63
26 83107 Renal cell carcinoma BioSystems: KEGG 2.017E-3 2.669E-2
1.713E-1
6.939E-1
 2 65
27 83085 Long-term potentiation BioSystems: KEGG 2.142E-3 2.693E-2
1.728E-1
7.368E-1
 2 67
28 83102 Epithelial cell signaling in Helicobacter pylori infection BioSystems: KEGG 2.205E-3 2.693E-2
1.728E-1
7.587E-1
 2 68
29 1457794 Signaling by MET BioSystems: REACTOME 2.270E-3 2.693E-2
1.728E-1
7.809E-1
 2 69
30 83116 Chronic myeloid leukemia BioSystems: KEGG 2.402E-3 2.754E-2
1.768E-1
8.261E-1
 2 71
31 1427866 RET signaling BioSystems: REACTOME 2.534E-3 2.812E-2
1.805E-1
8.716E-1
 3 273
32 1457781 Oncogenic MAPK signaling BioSystems: REACTOME 2.746E-3 2.937E-2
1.886E-1
9.447E-1
 2 76
33 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 2.818E-3 2.937E-2
1.886E-1
9.693E-1
 2 77
34 1269893 Regulation of gap junction activity BioSystems: REACTOME 3.130E-3 3.076E-2
1.974E-1
1.000E0
 1 3
35 1269894 c-src mediated regulation of Cx43 function and closure of gap junctions BioSystems: REACTOME 3.130E-3 3.076E-2
1.974E-1
1.000E0
 1 3
36 375172 Salmonella infection BioSystems: KEGG 3.501E-3 3.346E-2
2.148E-1
1.000E0
 2 86
37 83072 Gap junction BioSystems: KEGG 3.663E-3 3.405E-2
2.186E-1
1.000E0
 2 88
38 1457787 RAS signaling downstream of NF1 loss-of-function variants BioSystems: REACTOME 4.171E-3 3.753E-2
2.409E-1
1.000E0
 1 4
39 1270330 EPH-Ephrin signaling BioSystems: REACTOME 4.255E-3 3.753E-2
2.409E-1
1.000E0
 2 95
40 1269187 Activation of RAS in B cells BioSystems: REACTOME 5.211E-3 4.481E-2
2.877E-1
1.000E0
 1 5
41 P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PantherDB 5.763E-3 4.835E-2
3.104E-1
1.000E0
 2 111
42 83083 Leukocyte transendothelial migration BioSystems: KEGG 6.069E-3 4.880E-2
3.133E-1
1.000E0
 2 114
43 1268855 Diseases of signal transduction BioSystems: REACTOME 6.100E-3 4.880E-2
3.133E-1
1.000E0
 3 373
44 137951 EphrinB-EPHB pathway BioSystems: Pathway Interaction Database 6.250E-3 4.886E-2
3.137E-1
1.000E0
 1 6
Show 39 more annotations

8: Pubmed [Display Chart] 14 input genes in category / 3484 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17254020 The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. Pubmed 3.920E-11 1.366E-7 1.193E-6 1.366E-7 3 3
2 9523700 Identification of a specific effector of the small GTP-binding protein Rap2. Pubmed 3.919E-10 4.551E-7 3.975E-6 1.365E-6 3 5
3 25533468 Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. Pubmed 3.919E-10 4.551E-7 3.975E-6 1.365E-6 3 5
4 12581858 Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Pubmed 7.836E-10 6.825E-7 5.960E-6 2.730E-6 3 6
5 15469846 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Pubmed 1.371E-9 7.961E-7 6.952E-6 4.776E-6 3 7
6 10922060 The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Pubmed 1.371E-9 7.961E-7 6.952E-6 4.776E-6 3 7
7 11786539 The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. Pubmed 6.458E-9 3.214E-6 2.807E-5 2.250E-5 3 11
8 10926822 RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Pubmed 8.608E-9 3.332E-6 2.910E-5 2.999E-5 3 12
9 15031288 Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. Pubmed 8.608E-9 3.332E-6 2.910E-5 2.999E-5 3 12
10 22797597 Rap2A links intestinal cell polarity to brush border formation. Pubmed 1.779E-8 6.199E-6 5.413E-5 6.199E-5 3 15
11 10862698 Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Pubmed 2.041E-8 6.464E-6 5.646E-5 7.111E-5 4 83
12 26212757 Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Pubmed 8.974E-8 2.174E-5 1.898E-4 3.127E-4 3 25
13 14607972 Rap1 GTPase: functions, regulation, and malignancy. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
14 18056342 Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
15 12891710 Rap1, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
16 12202034 Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
17 19218462 Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
18 15031297 Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
19 17300802 Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
20 19700408 Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis. Pubmed 1.248E-7 2.174E-5 1.898E-4 4.347E-4 2 2
21 15254236 Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
22 15725075 Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
23 16698549 GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
24 3045729 Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
25 10608844 RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
26 11489913 Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
27 16963453 Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
28 15677455 Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
29 12904304 Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
30 17954608 KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
31 11022048 Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
32 10334923 In vivo interaction of AF-6 with activated Ras and ZO-1. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
33 23469100 Rap1 and Rap2 antagonistically control endothelial barrier resistance. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
34 23568966 Tissue-specific expression of occludin, zona occludens-1, and junction adhesion molecule A in the duodenum, ileum, colon, kidney, liver, lung, brain, and skeletal muscle of C57BL mice. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
35 17716979 Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
36 11880369 RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
37 24642466 Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
38 18789886 Beta2 integrins target Rap GTPases to the plasma membrane by means of degranulation. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
39 28170369 LMO2 Enhances Lamellipodia/Filopodia Formation in Basal-Type Breast Cancer Cells by Mediating ARP3-Profilin1 Interaction. Pubmed 3.742E-7 3.343E-5 2.920E-4 1.304E-3 2 3
40 12082090 MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
41 10085114 Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
42 11689568 Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
43 16540189 Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
44 21248063 Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
45 7862125 A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
46 17638918 BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
47 15657046 Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
48 12444546 Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
49 18596699 Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
50 24803656 The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. Pubmed 7.483E-7 4.919E-5 4.296E-4 2.607E-3 2 4
Show 45 more annotations

9: Interaction [Display Chart] 14 input genes in category / 1090 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:AFDN AFDN interactions 3.612E-28 3.937E-25 2.981E-24 3.937E-25 13 118
2 int:RALGDS RALGDS interactions 6.627E-9 3.612E-6 2.735E-5 7.224E-6 4 30
3 int:APBB1IP APBB1IP interactions 2.191E-7 7.962E-5 6.029E-4 2.389E-4 3 16
4 int:RASIP1 RASIP1 interactions 3.787E-7 8.676E-5 6.569E-4 4.128E-4 3 19
5 int:LATS2 LATS2 interactions 4.410E-7 8.676E-5 6.569E-4 4.807E-4 5 213
6 int:RASA1 RASA1 interactions 4.776E-7 8.676E-5 6.569E-4 5.206E-4 4 85
7 int:GRIN1 GRIN1 interactions 1.447E-6 2.253E-4 1.706E-3 1.577E-3 4 112
8 int:GRIN2D GRIN2D interactions 3.011E-6 4.103E-4 3.106E-3 3.282E-3 3 37
9 int:ZBTB12 ZBTB12 interactions 3.481E-6 4.216E-4 3.193E-3 3.795E-3 2 4
10 int:PPP1R13B PPP1R13B interactions 8.018E-6 8.617E-4 6.524E-3 8.739E-3 3 51
11 int:RASGRP4 RASGRP4 interactions 8.696E-6 8.617E-4 6.524E-3 9.478E-3 2 6
12 int:RGL4 RGL4 interactions 1.217E-5 1.020E-3 7.725E-3 1.326E-2 2 7
13 int:IL3 IL3 interactions 1.217E-5 1.020E-3 7.725E-3 1.326E-2 2 7
14 int:SOS1 SOS1 interactions 2.370E-5 1.845E-3 1.397E-2 2.583E-2 3 73
15 int:PARD3 PARD3 interactions 3.361E-5 2.442E-3 1.849E-2 3.663E-2 3 82
16 int:RAPGEF3 RAPGEF3 interactions 4.508E-5 3.071E-3 2.325E-2 4.913E-2 2 13
17 int:CEP128 CEP128 interactions 5.116E-5 3.280E-3 2.484E-2
5.577E-2
 4 276
18 int:TNIK TNIK interactions 5.563E-5 3.369E-3 2.551E-2
6.064E-2
 4 282
19 int:ERBIN ERBIN interactions 8.304E-5 4.764E-3 3.607E-2
9.051E-2
 3 111
20 int:RGS14 RGS14 interactions 1.095E-4 5.965E-3 4.517E-2
1.193E-1
 2 20
21 int:RAP1GAP RAP1GAP interactions 1.455E-4 7.208E-3
5.458E-2
1.586E-1
 2 23
22 int:RAPGEF4 RAPGEF4 interactions 1.455E-4 7.208E-3
5.458E-2
1.586E-1
 2 23
23 int:RAPGEF6 RAPGEF6 interactions 1.587E-4 7.208E-3
5.458E-2
1.730E-1
 2 24
24 int:ELF2 ELF2 interactions 1.587E-4 7.208E-3
5.458E-2
1.730E-1
 2 24
25 int:RAPGEF1 RAPGEF1 interactions 1.724E-4 7.229E-3
5.473E-2
1.879E-1
 2 25
26 int:F11R F11R interactions 1.724E-4 7.229E-3
5.473E-2
1.879E-1
 2 25
27 int:FBF1 FBF1 interactions 1.909E-4 7.708E-3
5.836E-2
2.081E-1
 3 147
28 int:BRAF BRAF interactions 2.190E-4 8.306E-3
6.289E-2
2.387E-1
 3 154
29 int:BTRC BTRC interactions 2.210E-4 8.306E-3
6.289E-2
2.409E-1
 4 403
30 int:CNTRL CNTRL interactions 2.451E-4 8.771E-3
6.641E-2
2.672E-1
 3 160
31 int:RAPGEF5 RAPGEF5 interactions 2.495E-4 8.771E-3
6.641E-2
2.719E-1
 2 30
32 int:DLGAP1 DLGAP1 interactions 2.780E-4 8.850E-3
6.701E-2
3.031E-1
 3 167
33 int:S1PR1 S1PR1 interactions 2.842E-4 8.850E-3
6.701E-2
3.098E-1
 2 32
34 int:PDE6D PDE6D interactions 2.842E-4 8.850E-3
6.701E-2
3.098E-1
 2 32
35 int:MGST3 MGST3 interactions 2.842E-4 8.850E-3
6.701E-2
3.098E-1
 2 32
36 int:ARHGEF1 ARHGEF1 interactions 3.404E-4 1.031E-2
7.805E-2
3.711E-1
 2 35
37 int:BEX2 BEX2 interactions 3.603E-4 1.061E-2
8.037E-2
3.927E-1
 2 36
38 int:PIK3CG PIK3CG interactions 4.017E-4 1.095E-2
8.288E-2
4.378E-1
 2 38
39 int:CYP2S1 CYP2S1 interactions 4.017E-4 1.095E-2
8.288E-2
4.378E-1
 2 38
40 int:TGS1 TGS1 interactions 4.017E-4 1.095E-2
8.288E-2
4.378E-1
 2 38
41 int:PHF19 PHF19 interactions 4.679E-4 1.244E-2
9.419E-2
5.100E-1
 2 41
42 int:MTOR MTOR interactions 4.856E-4 1.245E-2
9.425E-2
5.293E-1
 3 202
43 int:EFNB1 EFNB1 interactions 4.911E-4 1.245E-2
9.425E-2
5.353E-1
 2 42
44 int:RUNDC3A RUNDC3A interactions 5.148E-4 1.275E-2
9.656E-2
5.611E-1
 2 43
45 int:ABL2 ABL2 interactions 5.391E-4 1.306E-2
9.887E-2
5.876E-1
 2 44
46 int:RASSF5 RASSF5 interactions 5.639E-4 1.315E-2
9.953E-2
6.146E-1
 2 45
47 int:ACTA1 ACTA1 interactions 5.668E-4 1.315E-2
9.953E-2
6.178E-1
 3 213
48 int:RAF1 RAF1 interactions 7.178E-4 1.630E-2
1.234E-1
7.823E-1
 3 231
49 int:CDC42 CDC42 interactions 7.452E-4 1.641E-2
1.243E-1
8.122E-1
 3 234
50 int:RAB8B RAB8B interactions 7.529E-4 1.641E-2
1.243E-1
8.207E-1
 2 52
Show 45 more annotations

10: Cytoband [Display Chart] 14 input genes in category / 14 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q21.2-q21.3 1q21.2-q21.3 8.077E-4 1.131E-2 3.677E-2 1.131E-2 1 2
2 15q13 15q13 3.630E-3 1.694E-2
5.508E-2
5.082E-2
 1 9
3 1p36.1-p35 1p36.1-p35 3.630E-3 1.694E-2
5.508E-2
5.082E-2
 1 9
4 12q21.31 12q21.31 7.247E-3 1.930E-2
6.277E-2
1.015E-1
 1 18
5 1p22.3 1p22.3 8.851E-3 1.930E-2
6.277E-2
1.239E-1
 1 22
6 10q23.33 10q23.33 9.652E-3 1.930E-2
6.277E-2
1.351E-1
 1 24
7 3q21 3q21 9.652E-3 1.930E-2
6.277E-2
1.351E-1
 1 24
8 Xp11.4 Xp11.4 1.484E-2 2.598E-2
8.447E-2
2.078E-1
 1 37
9 22q11.23 22q11.23 2.160E-2 3.051E-2
9.919E-2
3.023E-1
 1 54
10 13q34 13q34 2.397E-2 3.051E-2
9.919E-2
3.356E-1
 1 60
11 11p13 11p13 2.397E-2 3.051E-2
9.919E-2
3.356E-1
 1 60
12 1p13.3 1p13.3 2.791E-2 3.256E-2
1.059E-1
3.908E-1
 1 70
13 17p13.3 17p13.3 3.692E-2 3.976E-2
1.293E-1
5.169E-1
 1 93
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 135 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 16 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 389 RAS type GTPase family genenames.org 5.331E-7 8.530E-6 2.884E-5 8.530E-6 3 31
2 1198 Ras association domain family genenames.org 5.484E-3 4.091E-2
1.383E-1
8.775E-2
 1 10
3 1095 Fibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors genenames.org 7.670E-3 4.091E-2
1.383E-1
1.227E-1
 1 14

13: Coexpression [Display Chart] 14 input genes in category / 1657 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 5.324E-5 2.104E-2
1.681E-1
8.822E-2
 4 364
2 M422 Genes down-regulated in dendritic cells: immature versus mature inhibitory treated by prostaglandin E2 [PubChem=5280360]. MSigDB C7: Immunologic Signatures (v6.0) 7.677E-5 2.104E-2
1.681E-1
1.272E-1
 3 141
3 M2137 Genes identified as synthetic lethal with imatinib [PubChem=5291] in RNAi screen in K562 cells (CML, chronic myelogenous leukemia). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.342E-5 2.104E-2
1.681E-1
1.382E-1
 3 145
4 12163391-Table2 Human Brain Watson02 24genes GeneSigDB 9.313E-5 2.104E-2
1.681E-1
1.543E-1
 2 24
5 M15009 Genes down-regulated in Kelly cells (neuroblastoma) by overexpressing INHBA [GeneID=3624] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.313E-5 2.104E-2
1.681E-1
1.543E-1
 2 24
6 16581771-table1 Mouse StemCell Si06 35genes GeneSigDB 1.465E-4 2.104E-2
1.681E-1
2.427E-1
 2 30
7 M8252 Genes down-regulated in B lymphocytes stimulated by anti-IgM for 16h: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.944E-4 2.104E-2
1.681E-1
3.221E-1
 3 193
8 M8400 Genes down-regulated in brain microglia versus spleen CD8- dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 2.096E-4 2.104E-2
1.681E-1
3.473E-1
 3 198
9 M4510 Genes up-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 48 h versus stimulated CD4 [GeneID=920] Th2 cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 2.127E-4 2.104E-2
1.681E-1
3.525E-1
 3 199
10 M4944 Genes down-regulated in comparison of B cells versus myeloid dendritic cells (mDC). MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
11 M7290 Genes up-regulated in lymphocytes treated with medium for 24h: T conv versus T reg cells. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
12 M4545 Genes up-regulated in comparison of thymic progenitors versus DN2 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
13 M5172 Genes up-regulated in comparison of dendritic cells (DC) versus untreated macrophages. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
14 M2719 Genes down-regulated in primary thyrocyte cultures in response to cAMP signaling pathway activation by thyrotropin (TSH). MSigDB C6: Oncogenic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
15 M7447 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: TGF beta versus TGF beta and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
16 M6038 Genes up-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
17 M5915 Genes encoding components of apical junction complex. MSigDB H: Hallmark Gene Sets (v6.0) 2.159E-4 2.104E-2
1.681E-1
3.577E-1
 3 200
18 15955831-Table4 Human StemCell Komor05 39genes GeneSigDB 2.487E-4 2.290E-2
1.830E-1
4.122E-1
 2 39
19 M3961 Genes with GO annotation and up-regulated after DNA damage in cell lines from young donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.052E-4 2.661E-2
2.127E-1
5.057E-1
 3 225
20 17970077-Table5 Human Viral Uchimura07 50genes GeneSigDB 3.619E-4 2.915E-2
2.329E-1
5.996E-1
 2 47
21 18537973-SuppTable1b Human Lymphoma Miyazaki08 70genes GeneSigDB 3.775E-4 2.915E-2
2.329E-1
6.255E-1
 2 48
22 M19693 Genes up-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.870E-4 2.915E-2
2.329E-1
6.412E-1
 3 244
23 16204010-SuppTable Human Ovarian Spentzos05 93genes GeneSigDB 5.139E-4 3.591E-2
2.869E-1
8.516E-1
 2 56
24 M11472 Genes down-regulated in three-dimentional (3D) cultures of preinvasive (S3-C) vs invasive (T4-2) breast cancer cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.201E-4 3.591E-2
2.869E-1
8.618E-1
 3 270
Show 19 more annotations

14: Coexpression Atlas [Display Chart] 14 input genes in category / 1496 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Kidney10XCellRanger Six2KI P0 Endo Endo Top 200 Kidney10XCellRanger Six2KI P0 Endo Endo Top 200 1.494E-8 2.235E-5 1.763E-4 2.235E-5 6 292
2 Kidney10XCellRanger Six2KI P0 Endo Endo Subtype P0-Six2KI-Endo-C4-KC8 Top 200 Genes Kidney10XCellRanger Six2KI P0 Endo Endo Subtype P0-Six2KI-Endo-C4-KC8 Top 200 Genes 1.179E-7 8.816E-5 6.954E-4 1.763E-4 5 201
3 Kidney10XCellRanger Six2KI P0 Endo Endo Subtype P0-Six2KI-Endo-C7-KC8 Top 200 Genes Kidney10XCellRanger Six2KI P0 Endo Endo Subtype P0-Six2KI-Endo-C7-KC8 Top 200 Genes 4.477E-7 2.233E-4 1.761E-3 6.698E-4 5 263
4 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes 2.131E-6 7.969E-4 6.286E-3 3.188E-3 5 361
5 Kidney10XCellRanger Six2KI E14 Endo Endo Overall Top 200 Genes Kidney10XCellRanger Six2KI E14 Endo Endo Overall Top 200 Genes 4.678E-6 1.088E-3 8.584E-3 6.998E-3 4 185
6 Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC8 Top 200 Genes Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC8 Top 200 Genes 4.882E-6 1.088E-3 8.584E-3 7.303E-3 4 187
7 Kidney10XCellRanger Six2KI P0 Endo Endo Overall Top 200 Genes Kidney10XCellRanger Six2KI P0 Endo Endo Overall Top 200 Genes 5.092E-6 1.088E-3 8.584E-3 7.617E-3 4 189
8 Lungmap Mouse Lung E16.5 Endothelial Lungmap Mouse Lung E16.5 Endothelial Lungmap CCHMC 6.252E-6 1.169E-3 9.222E-3 9.353E-3 5 450
9 Kidney10XCellRanger Six2KI P0 Endo Endo Subtype P0-Six2KI-Endo-C6-KC8 Top 200 Genes Kidney10XCellRanger Six2KI P0 Endo Endo Subtype P0-Six2KI-Endo-C6-KC8 Top 200 Genes 7.299E-6 1.213E-3 9.570E-3 1.092E-2 4 207
10 Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC1 Top 200 Genes Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC1 Top 200 Genes 3.059E-5 4.576E-3 3.609E-2 4.576E-2 4 298
11 Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC4 Top 200 Genes Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC4 Top 200 Genes 4.089E-5 5.561E-3 4.387E-2
6.117E-2
 4 321
12 Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC2 Top 200 Genes Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC2 Top 200 Genes 4.829E-5 6.021E-3 4.749E-2
7.225E-2
 4 335
13 Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC10 Top 200 Genes Kidney10XCellRanger Six2TGC E14 Endo Endo Subtype E14-Six2TGC-Endo-C3-KC10 Top 200 Genes 5.791E-5 6.537E-3
5.157E-2
8.663E-2
 4 351
14 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells B Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells B Top 200 Genes 6.118E-5 6.537E-3
5.157E-2
9.152E-2
 4 356
15 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Oligodendrocyte/Oligodendrocyte/Oligodendrocyte/Tnf BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Oligodendrocyte/Oligodendrocyte/Oligodendrocyte/Tnf BrainMap 1.375E-4 1.372E-2
1.082E-1
2.057E-1
 3 162
16 Lung Development Lungmap - Mouse FluidigmC1 Endothelial Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Endothelial Overall Top 500 Genes 1.620E-4 1.477E-2
1.165E-1
2.424E-1
 4 458
17 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Overall Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Overall Top 200 Genes 1.877E-4 1.477E-2
1.165E-1
2.808E-1
 3 180
18 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Overall Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Overall Top 200 Genes 1.939E-4 1.477E-2
1.165E-1
2.901E-1
 3 182
19 Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Overall Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Overall Top 200 Genes 1.971E-4 1.477E-2
1.165E-1
2.949E-1
 3 183
20 Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Subtype P0-Six2TGC Tsc1-Endo-C8-KC6 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 P0 Endo Endo Subtype P0-Six2TGC Tsc1-Endo-C8-KC6 Top 200 Genes 2.068E-4 1.477E-2
1.165E-1
3.093E-1
 3 186
21 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/endothelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/endothelial cell Tabula Muris Consortium 2.134E-4 1.477E-2
1.165E-1
3.192E-1
 3 188
22 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Overall Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Overall Top 200 Genes StanfordMouse+HumanSingleCells 2.270E-4 1.477E-2
1.165E-1
3.396E-1
 3 192
23 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B Top 200 Genes 2.270E-4 1.477E-2
1.165E-1
3.396E-1
 3 192
24 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C Top 200 Genes 2.636E-4 1.486E-2
1.172E-1
3.943E-1
 3 202
25 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND01-03 Top 200 Genes 2.792E-4 1.486E-2
1.172E-1
4.177E-1
 3 206
26 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B PND07-28 Top 200 Genes 2.913E-4 1.486E-2
1.172E-1
4.358E-1
 3 209
27 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells B E18.5 Top 200 Genes 2.954E-4 1.486E-2
1.172E-1
4.420E-1
 3 210
28 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C PND07-28 Top 200 Genes 2.996E-4 1.486E-2
1.172E-1
4.482E-1
 3 211
29 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells C PND01-03 Top 200 Genes 2.996E-4 1.486E-2
1.172E-1
4.482E-1
 3 211
30 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells D Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells D Top 200 Genes 3.080E-4 1.486E-2
1.172E-1
4.608E-1
 3 213
31 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells D PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells D PND01-03 Top 200 Genes 3.253E-4 1.486E-2
1.172E-1
4.866E-1
 3 217
32 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Fetal Endothelial E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Fetal Endothelial E16.5 Top 200 Genes 3.431E-4 1.486E-2
1.172E-1
5.133E-1
 3 221
33 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Fetal Endothelial Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Fetal Endothelial Top 200 Genes 3.431E-4 1.486E-2
1.172E-1
5.133E-1
 3 221
34 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells A Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells A Top 200 Genes 3.477E-4 1.486E-2
1.172E-1
5.202E-1
 3 222
35 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells A E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells A E18.5 Top 200 Genes 3.477E-4 1.486E-2
1.172E-1
5.202E-1
 3 222
36 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Matrix Endothelial Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Matrix Endothelial Top 200 Genes 4.262E-4 1.723E-2
1.359E-1
6.377E-1
 3 238
37 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Matrix Endothelial E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Matrix Endothelial E16.5 Top 200 Genes 4.262E-4 1.723E-2
1.359E-1
6.377E-1
 3 238
38 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Proliferative Endothelial E16.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Proliferative Endothelial E16.5 Top 200 Genes 4.639E-4 1.754E-2
1.384E-1
6.940E-1
 3 245
39 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Proliferative Endothelial Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype Proliferative Endothelial Top 200 Genes 4.639E-4 1.754E-2
1.384E-1
6.940E-1
 3 245
40 gudmap kidney adult RenMedVasc Tie2 k3 200 kidney adult RenMedVasc Tie2 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.783E-4 1.754E-2
1.384E-1
7.156E-1
 2 51
41 Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells D PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Endothelial Endothelial Subtype endothelial cells D PND07-28 Top 200 Genes 4.807E-4 1.754E-2
1.384E-1
7.191E-1
 3 248
42 gudmap RNAseq e15.5 Endothelial 2500 K4 gudmap RNAseq e15.5 Endothelial 2500 K4 Gudmap RNAseq 7.205E-4 2.566E-2
2.024E-1
1.000E0
 3 285
43 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s3 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s3 Top 200 Genes StanfordMouse+HumanSingleCells 7.807E-4 2.716E-2
2.143E-1
1.000E0
 3 293
44 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells D Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells D Top 200 Genes 8.041E-4 2.734E-2
2.157E-1
1.000E0
 3 296
45 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-B(1) Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-B(1) Lungmap CCHMC 8.605E-4 2.792E-2
2.202E-1
1.000E0
 3 303
46 Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC7 Top 200 Genes Kidney10XCellRanger Six2TGC P0 Stroma Stroma Subtype P0-Six2TGC-Stroma2-C4-KC7 Top 200 Genes 8.770E-4 2.792E-2
2.202E-1
1.000E0
 3 305
47 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells D PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells D PND01-03 Top 200 Genes 8.770E-4 2.792E-2
2.202E-1
1.000E0
 3 305
48 Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells D PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Endothelial Subtype endothelial cells D PND07-28 Top 200 Genes 9.022E-4 2.812E-2
2.218E-1
1.000E0
 3 308
49 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap 1.035E-3 2.967E-2
2.340E-1
1.000E0
 3 323
50 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/1/5 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/1/5 TCGA-Colorectal 1.087E-3 2.967E-2
2.340E-1
1.000E0
 2 77
Show 45 more annotations

15: Computational [Display Chart] 13 input genes in category / 85 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13925 MODULE 86 Small monomeric GTPases. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.033E-5 1.728E-3 8.686E-3 1.728E-3 3 43

16: MicroRNA [Display Chart] 14 input genes in category / 643 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TACTTGA,MIR-26B:MSigDB TACTTGA,MIR-26B:MSigDB MSigDB 2.238E-7 7.194E-5 5.068E-4 1.439E-4 4 283
2 TACTTGA,MIR-26A:MSigDB TACTTGA,MIR-26A:MSigDB MSigDB 2.238E-7 7.194E-5 5.068E-4 1.439E-4 4 283
3 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 8.959E-7 1.848E-4 1.302E-3 5.761E-4 4 401
4 hsa-miR-26b:PITA hsa-miR-26b:PITA TOP PITA 1.724E-6 1.848E-4 1.302E-3 1.109E-3 4 473
5 hsa-miR-1297:PITA hsa-miR-1297:PITA TOP PITA 1.724E-6 1.848E-4 1.302E-3 1.109E-3 4 473
6 hsa-miR-26a:PITA hsa-miR-26a:PITA TOP PITA 1.724E-6 1.848E-4 1.302E-3 1.109E-3 4 473
7 hsa-miR-326:PITA hsa-miR-326:PITA TOP PITA 6.281E-6 4.725E-4 3.328E-3 4.038E-3 3 189
8 hsa-miR-330-5p:PITA hsa-miR-330-5p:PITA TOP PITA 6.281E-6 4.725E-4 3.328E-3 4.038E-3 3 189
9 hsa-miR-585-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.613E-6 4.725E-4 3.328E-3 4.252E-3 2 20
10 TGCTTTG,MIR-330:MSigDB TGCTTTG,MIR-330:MSigDB MSigDB 2.857E-5 1.837E-3 1.294E-2 1.837E-2 3 314
11 hsa-miR-1268b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.914E-5 2.114E-3 1.489E-2 2.517E-2 2 48
12 hsa-miR-1200:PITA hsa-miR-1200:PITA TOP PITA 3.945E-5 2.114E-3 1.489E-2 2.536E-2 3 350
13 hsa-miR-1268a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.599E-5 2.275E-3 1.602E-2 2.957E-2 2 52
14 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 5.604E-5 2.574E-3 1.813E-2 3.604E-2 3 394
15 hsa-miR-1284:PITA hsa-miR-1284:PITA TOP PITA 7.111E-5 3.048E-3 2.147E-2 4.573E-2 3 427
16 hsa-miR-10a-5p:Functional MTI Functional MTI miRTarbase 9.034E-5 3.464E-3 2.440E-2
5.809E-2
 3 463
17 hsa-miR-203a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.345E-5 3.464E-3 2.440E-2
6.009E-2
 2 74
18 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 1.023E-4 3.464E-3 2.440E-2
6.581E-2
 3 483
19 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 1.023E-4 3.464E-3 2.440E-2
6.581E-2
 3 483
20 hsa-miR-1283:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.322E-4 4.251E-3 2.995E-2
8.503E-2
 2 88
21 AACTGAC,MIR-223:MSigDB AACTGAC,MIR-223:MSigDB MSigDB 1.477E-4 4.410E-3 3.107E-2
9.497E-2
 2 93
22 hsa-miR-4799-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.509E-4 4.410E-3 3.107E-2
9.702E-2
 2 94
23 hsa-miR-617:PITA hsa-miR-617:PITA TOP PITA 1.674E-4 4.679E-3 3.296E-2
1.076E-1
 2 99
24 hsa-miR-224-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.219E-4 5.807E-3 4.090E-2
1.427E-1
 2 114
25 hsa-miR-522-3p:Non-Functional MTI Non-Functional MTI miRTarbase 2.258E-4 5.807E-3 4.090E-2
1.452E-1
 2 115
26 hsa-miR-6827-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.458E-4 6.078E-3 4.282E-2
1.580E-1
 2 120
27 hsa-miR-6732-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.883E-4 6.825E-3 4.808E-2
1.854E-1
 2 130
28 hsa-miR-340-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.972E-4 6.825E-3 4.808E-2
1.911E-1
 2 132
29 hsa-miR-455-5p:PITA hsa-miR-455-5p:PITA TOP PITA 3.201E-4 6.960E-3 4.903E-2
2.058E-1
 2 137
30 GAGCCAG,MIR-149:MSigDB GAGCCAG,MIR-149:MSigDB MSigDB 3.247E-4 6.960E-3 4.903E-2
2.088E-1
 2 138
31 hsa-miR-4486:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.390E-4 7.031E-3 4.952E-2
2.179E-1
 2 141
32 CCCAGAG,MIR-326:MSigDB CCCAGAG,MIR-326:MSigDB MSigDB 3.683E-4 7.273E-3
5.123E-2
2.368E-1
 2 147
33 hsa-miR-1274a:PITA hsa-miR-1274a:PITA TOP PITA 3.733E-4 7.273E-3
5.123E-2
2.400E-1
 2 148
34 hsa-miR-502-3p:PITA hsa-miR-502-3p:PITA TOP PITA 4.860E-4 8.491E-3
5.981E-2
3.125E-1
 2 169
35 hsa-miR-149:PITA hsa-miR-149:PITA TOP PITA 4.917E-4 8.491E-3
5.981E-2
3.162E-1
 2 170
36 hsa-miR-501-3p:PITA hsa-miR-501-3p:PITA TOP PITA 4.917E-4 8.491E-3
5.981E-2
3.162E-1
 2 170
37 hsa-miR-10a:PITA hsa-miR-10a:PITA TOP PITA 5.091E-4 8.491E-3
5.981E-2
3.274E-1
 2 173
38 hsa-miR-10b:PITA hsa-miR-10b:PITA TOP PITA 5.091E-4 8.491E-3
5.981E-2
3.274E-1
 2 173
39 hsa-miR-125a-3p:PITA hsa-miR-125a-3p:PITA TOP PITA 5.150E-4 8.491E-3
5.981E-2
3.311E-1
 2 174
40 hsa-miR-584:PITA hsa-miR-584:PITA TOP PITA 5.817E-4 9.319E-3
6.564E-2
3.740E-1
 2 185
41 hsa-miR-759:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.942E-4 9.319E-3
6.564E-2
3.821E-1
 2 187
42 hsa-miR-876-5p:PITA hsa-miR-876-5p:PITA TOP PITA 6.656E-4 1.019E-2
7.178E-2
4.280E-1
 2 198
43 hsa-miR-1321:PITA hsa-miR-1321:PITA TOP PITA 6.857E-4 1.025E-2
7.223E-2
4.409E-1
 2 201
44 hsa-miR-760:PITA hsa-miR-760:PITA TOP PITA 7.479E-4 1.050E-2
7.394E-2
4.809E-1
 2 210
45 TTTTGAG,MIR-373:MSigDB TTTTGAG,MIR-373:MSigDB MSigDB 7.621E-4 1.050E-2
7.394E-2
4.900E-1
 2 212
46 hsa-miR-361-5p:TargetScan hsa-miR-361-5p TargetScan 7.764E-4 1.050E-2
7.394E-2
4.992E-1
 2 214
47 hsa-miR-329:PITA hsa-miR-329:PITA TOP PITA 7.836E-4 1.050E-2
7.394E-2
5.039E-1
 2 215
48 hsa-miR-362-3p:PITA hsa-miR-362-3p:PITA TOP PITA 7.836E-4 1.050E-2
7.394E-2
5.039E-1
 2 215
49 hsa-miR-654-3p:PITA hsa-miR-654-3p:PITA TOP PITA 8.127E-4 1.067E-2
7.513E-2
5.226E-1
 2 219
50 hsa-miR-24:PITA hsa-miR-24:PITA TOP PITA 8.424E-4 1.083E-2
7.631E-2
5.417E-1
 2 223
Show 45 more annotations

17: Drug [Display Chart] 14 input genes in category / 3614 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000657007 1-4a Stitch 8.379E-8 3.028E-4 2.656E-3 3.028E-4 4 71
2 CID000166768 p-hydroxymandelonitrile Stitch 6.291E-7 9.261E-4 8.122E-3 2.274E-3 4 117
3 CID000448294 AC1L9LT0 Stitch 7.688E-7 9.261E-4 8.122E-3 2.778E-3 4 123
4 CID000008474 metanilic acid Stitch 1.046E-6 9.453E-4 8.290E-3 3.781E-3 2 3
5 ctd:C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CTD 2.824E-6 2.041E-3 1.790E-2 1.020E-2 5 400
6 DB04137 Guanosine-5'-Triphosphate Drug Bank 3.485E-6 2.099E-3 1.841E-2 1.259E-2 2 5
7 2940 UP Methyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.822E-6 2.314E-3 2.030E-2 1.743E-2 4 195
8 5064 DN Ornidazole [16773-42-5]; Down 200; 18.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.123E-6 2.314E-3 2.030E-2 1.851E-2 4 198
9 ctd:C073007 ibandronic acid CTD 9.748E-6 3.914E-3 3.433E-2 3.523E-2 2 8
10 DB04315 Guanosine-5'-Diphosphate Drug Bank 2.711E-5 9.796E-3
8.591E-2
9.796E-2
 2 13
11 ctd:D000068296 Risedronate Sodium CTD 3.161E-5 1.039E-2
9.109E-2
1.143E-1
 2 14
12 CID005288823 heptamolybdate Stitch 4.016E-5 1.210E-2
1.061E-1
1.452E-1
 3 112
13 ctd:C104820 N-(3-(aminomethyl)benzyl)acetamidine CTD 4.720E-5 1.218E-2
1.068E-1
1.706E-1
 2 17
14 CID003060593 AC1MHZYF Stitch 4.720E-5 1.218E-2
1.068E-1
1.706E-1
 2 17
15 ctd:C017338 geranylgeraniol CTD 5.308E-5 1.279E-2
1.122E-1
1.918E-1
 2 18
16 ctd:C416927 SU 6656 CTD 6.587E-5 1.400E-2
1.228E-1
2.380E-1
 2 20
17 CID000644262 B-Go Stitch 6.587E-5 1.400E-2
1.228E-1
2.380E-1
 2 20
18 CID000003541 AC1MBZ1C Stitch 7.100E-5 1.426E-2
1.250E-1
2.566E-1
 4 387
19 CID003038489 Lauroguadine Stitch 1.124E-4 2.139E-2
1.876E-1
4.063E-1
 2 26
20 ctd:D017632 Asbestos, Serpentine CTD 1.316E-4 2.348E-2
2.060E-1
4.757E-1
 4 454
21 6546 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.538E-4 2.348E-2
2.060E-1
5.558E-1
 3 176
22 5743 DN Cycloheximide [66-81-9]; Down 200; 14.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.671E-4 2.348E-2
2.060E-1
6.037E-1
 3 181
23 1971 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP Up 1.928E-4 2.348E-2
2.060E-1
6.966E-1
 3 190
24 2846 UP Trimethadione [127-48-0]; Up 200; 28uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.988E-4 2.348E-2
2.060E-1
7.185E-1
 3 192
25 942 UP prazosin hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 2.050E-4 2.348E-2
2.060E-1
7.407E-1
 3 194
26 4839 DN Sulfaguanidine [57-67-0]; Down 200; 18.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.050E-4 2.348E-2
2.060E-1
7.407E-1
 3 194
27 CID000003037 Dichloro-phen Stitch 2.052E-4 2.348E-2
2.060E-1
7.416E-1
 2 35
28 2283 DN Hydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.081E-4 2.348E-2
2.060E-1
7.520E-1
 3 195
29 1990 UP Diflunisal [22494-42-4]; Up 200; 16uM; HL60; HG-U133A Broad Institute CMAP Up 2.112E-4 2.348E-2
2.060E-1
7.634E-1
 3 196
30 1968 UP Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; HL60; HG-U133A Broad Institute CMAP Up 2.112E-4 2.348E-2
2.060E-1
7.634E-1
 3 196
31 2035 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP Up 2.112E-4 2.348E-2
2.060E-1
7.634E-1
 3 196
32 1556 DN Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP Down 2.144E-4 2.348E-2
2.060E-1
7.750E-1
 3 197
33 2177 UP Benfotiamine [22457-89-2]; Up 200; 8.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.144E-4 2.348E-2
2.060E-1
7.750E-1
 3 197
34 CID004489307 AC1NB8R3 Stitch 2.698E-4 2.868E-2
2.515E-1
9.750E-1
 3 213
35 CID000005976 dimethylhydrazine Stitch 2.822E-4 2.914E-2
2.555E-1
1.000E0
 2 41
36 CID000124370 2-piperazinotetralin Stitch 2.962E-4 2.973E-2
2.608E-1
1.000E0
 2 42
37 CID003060591 AC1MHZY9 Stitch 3.105E-4 3.033E-2
2.660E-1
1.000E0
 2 43
38 CID000083697 hydroxyisocaproate Stitch 3.252E-4 3.093E-2
2.712E-1
1.000E0
 2 44
39 ctd:C012526 quercitrin CTD 4.164E-4 3.858E-2
3.384E-1
1.000E0
 3 247
40 CID000004133 methyl salicylate Stitch 4.372E-4 3.950E-2
3.465E-1
1.000E0
 2 51
41 CID000076495 tridodecyl phosphite Stitch 4.722E-4 4.028E-2
3.532E-1
1.000E0
 2 53
42 CID000448384 de-O Stitch 5.085E-4 4.028E-2
3.532E-1
1.000E0
 2 55
43 CID000448022 1q6k Stitch 5.655E-4 4.028E-2
3.532E-1
1.000E0
 2 58
44 DB08751 N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE Drug Bank 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
45 ctd:D009353 Zinostatin CTD 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
46 CID000083674 xenon difluoride Stitch 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
47 CID000096902 tetrapentyltin Stitch 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
48 CID000440258 C04208 Stitch 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
49 ctd:D011005 Plutonium CTD 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
50 CID000072906 pBPH4 Stitch 6.129E-4 4.028E-2
3.532E-1
1.000E0
 1 1
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 706 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0040136 Thyroid Neoplasm DisGeNET Curated 1.119E-4 2.574E-2
1.837E-1
7.903E-2
 4 336
2 C0003076 Aniridia DisGeNET Curated 1.360E-4 2.574E-2
1.837E-1
9.601E-2
 2 22
3 C0432333 Abnormal dermatoglyphic pattern DisGeNET Curated 1.764E-4 2.574E-2
1.837E-1
1.245E-1
 2 25
4 C0279543 Philadelphia chromosome positive chronic myelogenous leukemia DisGeNET BeFree 2.219E-4 2.574E-2
1.837E-1
1.567E-1
 2 28
5 C1844505 Pointed chin DisGeNET Curated 3.093E-4 2.574E-2
1.837E-1
2.184E-1
 2 33
6 C0238461 Anaplastic thyroid carcinoma DisGeNET Curated 3.437E-4 2.574E-2
1.837E-1
2.426E-1
 3 178
7 C0003492 Aortic coarctation DisGeNET Curated 4.329E-4 2.574E-2
1.837E-1
3.056E-1
 2 39
8 C1868571 Thick, flared eyebrows DisGeNET Curated 4.786E-4 2.574E-2
1.837E-1
3.379E-1
 2 41
9 C4020849 Bowed and upward slanting eyebrows DisGeNET Curated 4.786E-4 2.574E-2
1.837E-1
3.379E-1
 2 41
10 C0935681 Non-Hematologic Malignancy DisGeNET BeFree 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
11 cv:CN143708 Amyotrophic lateral sclerosis 18 Clinical Variations 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
12 cv:C0023473 Chronic myeloid leukemia Clinical Variations 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
13 C0334328 Microfollicular adenoma DisGeNET BeFree 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
14 OMIN:608232 LEUKEMIA, CHRONIC MYELOID; CML OMIM 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
15 cv:C0587248 Costello syndrome Clinical Variations 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
16 C2931658 Phacomatosis pigmentokeratotica DisGeNET Curated 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
17 cv:CN186197 Mental retardation, X-linked 99 Clinical Variations 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
18 C0346099 Nevus spilus DisGeNET BeFree 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
19 C0042548 Plantar wart DisGeNET BeFree 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
20 C3806746 MENTAL RETARDATION, X-LINKED 99 DisGeNET Curated 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
21 C3553719 AMYOTROPHIC LATERAL SCLEROSIS 18 DisGeNET Curated 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
22 C0456877 High grade T-cell lymphoma DisGeNET BeFree 8.022E-4 2.574E-2
1.837E-1
5.664E-1
 1 1
23 C0027659 Neoplasms, Experimental DisGeNET Curated 8.928E-4 2.741E-2
1.956E-1
6.303E-1
 2 56
24 C0079748 Precursor cell lymphoblastic lymphoma DisGeNET BeFree 1.129E-3 3.320E-2
2.370E-1
7.968E-1
 2 63
25 C0233315 Premature birth of newborn DisGeNET Curated 1.275E-3 3.448E-2
2.461E-1
9.005E-1
 2 67
26 C0346023 Syringocystadenoma DisGeNET BeFree 1.604E-3 3.448E-2
2.461E-1
1.000E0
 1 2
27 C0919997 Thickened Achilles tendon DisGeNET Curated 1.604E-3 3.448E-2
2.461E-1
1.000E0
 1 2
28 C3277753 Deep-set nails DisGeNET Curated 1.604E-3 3.448E-2
2.461E-1
1.000E0
 1 2
29 OMIN:218040 COSTELLO SYNDROME OMIM 1.604E-3 3.448E-2
2.461E-1
1.000E0
 1 2
30 C0278785 recurrent adult acute lymphoblastic leukemia DisGeNET BeFree 1.604E-3 3.448E-2
2.461E-1
1.000E0
 1 2
31 C0151526 Premature Birth DisGeNET Curated 1.637E-3 3.448E-2
2.461E-1
1.000E0
 2 76
32 C3553764 Joint hyperflexibility DisGeNET Curated 1.724E-3 3.448E-2
2.461E-1
1.000E0
 2 78
33 C3278024 Enlarged cerebellum DisGeNET Curated 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
34 C2678480 Chromosome 22q11.2 Deletion Syndrome, Distal DisGeNET Curated 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
35 C4025736 Abnormality of basophils DisGeNET Curated 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
36 C1622345 Meretoja syndrome DisGeNET Curated 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
37 C0265329 Organoid Nevus Phakomatosis DisGeNET BeFree 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
38 C2674737 Finger abnormalities DisGeNET Curated 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
39 C0334263 Trichilemmoma DisGeNET Curated 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
40 cv:C0023449 Acute lymphoid leukemia Clinical Variations 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
41 C2717981 Poroma DisGeNET BeFree 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
42 C1332899 Cerebellar Glioblastoma DisGeNET BeFree 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
43 C1533161 Eccrine Poroma DisGeNET BeFree 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
44 cv:C0265318 Epidermal nevus syndrome Clinical Variations 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
45 C0406803 Syringocystadenoma Papilliferum DisGeNET BeFree 2.405E-3 3.448E-2
2.461E-1
1.000E0
 1 3
46 C0024301 Lymphoma, Follicular DisGeNET Curated 2.412E-3 3.448E-2
2.461E-1
1.000E0
 3 349
47 C0026985 Myelodysplasia DisGeNET Curated 2.439E-3 3.448E-2
2.461E-1
1.000E0
 2 93
48 C0751072 Frontotemporal Lobar Degeneration DisGeNET Curated 2.650E-3 3.448E-2
2.461E-1
1.000E0
 2 97
49 C0023480 Leukemia, Myelomonocytic, Chronic DisGeNET Curated 3.096E-3 3.448E-2
2.461E-1
1.000E0
 2 105
50 OMIN:162900 NEVUS, EPIDERMAL OMIM 3.205E-3 3.448E-2
2.461E-1
1.000E0
 1 4
Show 45 more annotations