|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
11753387
|
Positional cloning of the combined hyperlipidemia gene Hyplip1.
|
Pubmed
|
1.751E-23
|
2.874E-20
|
2.293E-19
|
2.874E-20
|
7
|
9
|
|
2
|
18326817
|
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
|
Pubmed
|
1.721E-8
|
1.412E-5
|
1.127E-4
|
2.823E-5
|
3
|
13
|
|
3
|
15998830
|
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
4
|
27072365
|
Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
5
|
22398782
|
Serum hemojuvelin and hepcidin levels in chronic kidney disease.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
6
|
23375327
|
Hemojuvelin and iron metabolism in kidney and heart allograft recipients.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
7
|
16075058
|
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
8
|
24356769
|
Obesity does not influence hepcidin and hemojuvelin levels in hemodialysis patients.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
9
|
18421430
|
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
10
|
21088809
|
Hemojuvelin and hepcidin gene mutations in patients with porphyria cutanea tarda from Southern France.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
11
|
15685557
|
Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
12
|
20301349
|
Juvenile Hereditary Hemochromatosis
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
13
|
26405701
|
The Relationship of Serum Hemojuvelin and Hepcidin Levels with Iron Overload in Nonalcoholic Fatty Liver Disease.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
14
|
18445598
|
Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
15
|
18827264
|
Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
16
|
19564337
|
Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
17
|
19287179
|
Hemojuvelin: the hepcidin story continues.
|
Pubmed
|
1.645E-7
|
1.588E-5
|
1.268E-4
|
2.700E-4
|
2
|
2
|
|
18
|
16103673
|
Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
19
|
18287331
|
Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
20
|
28924039
|
Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
21
|
21039223
|
Hemojuvelin and hepcidin genes sequencing in Brazilian patients with primary iron overload.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
22
|
18335997
|
Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
23
|
20937842
|
Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
24
|
19214511
|
Mutations in HAMP and HJV genes and their impact on expression of clinical hemochromatosis in a cohort of 100 Spanish patients homozygous for the C282Y mutation of HFE gene.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
25
|
22893705
|
Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
26
|
22365732
|
Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy.
|
Pubmed
|
4.935E-7
|
3.115E-5
|
2.486E-4
|
8.098E-4
|
2
|
3
|
|
27
|
27051019
|
BMP6 and BMP4 expression in patients with cancer-related anemia and its relationship with hepcidin and s-HJV.
|
Pubmed
|
9.867E-7
|
5.397E-5
|
4.307E-4
|
1.619E-3
|
2
|
4
|
|
28
|
26633544
|
The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data.
|
Pubmed
|
9.867E-7
|
5.397E-5
|
4.307E-4
|
1.619E-3
|
2
|
4
|
|
29
|
18762941
|
Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes.
|
Pubmed
|
9.867E-7
|
5.397E-5
|
4.307E-4
|
1.619E-3
|
2
|
4
|
|
30
|
17942375
|
Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J.
|
Pubmed
|
9.867E-7
|
5.397E-5
|
4.307E-4
|
1.619E-3
|
2
|
4
|
|
31
|
16032658
|
Gene expression of the repulsive guidance molecules during development of the mouse intestine.
|
Pubmed
|
1.644E-6
|
8.703E-5
|
6.946E-4
|
2.698E-3
|
2
|
5
|
|
32
|
19787796
|
HFE, SLC40A1, HAMP, HJV, TFR2, and FTL mutations detected by denaturing high-performance liquid chromatography after iron phenotyping and HFE C282Y and H63D genotyping in 785 HEIRS Study participants.
|
Pubmed
|
2.466E-6
|
1.264E-4
|
1.009E-3
|
4.046E-3
|
2
|
6
|
|
33
|
19252486
|
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.
|
Pubmed
|
5.913E-6
|
2.940E-4
|
2.347E-3
|
9.703E-3
|
2
|
9
|
|
34
|
17847004
|
Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.
|
Pubmed
|
9.029E-6
|
4.358E-4
|
3.478E-3
|
1.482E-2
|
2
|
11
|
|
35
|
20065295
|
Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.
|
Pubmed
|
1.083E-5
|
5.079E-4
|
4.053E-3
|
1.778E-2
|
2
|
12
|
|
36
|
20801192
|
Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
37
|
28455998
|
New mutations in GJA8 expand the phenotype to include total sclerocornea.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
38
|
16868025
|
Complex biosynthesis of the muscle-enriched iron regulator RGMc.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
39
|
29149203
|
ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
40
|
26055723
|
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
41
|
26174669
|
Mutant connexin 50 (S276F) inhibits channel and hemichannel functions inducing cataract.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
42
|
24283717
|
Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
43
|
20713458
|
Immunoassay for human serum hemojuvelin.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
44
|
11023900
|
Properties of gap junction channels formed by Cx46 alone and in combination with Cx50.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
45
|
30056060
|
Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
46
|
18333366
|
IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
47
|
30057485
|
Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
48
|
24954786
|
Hepcidin in tumor-related iron deficiency anemia and tumor-related anemia of chronic disease: pathogenic mechanisms and diagnosis.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
49
|
27702549
|
Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|
|
50
|
17675577
|
High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1.
|
Pubmed
|
4.189E-4
|
1.088E-3
|
8.681E-3
|
6.875E-1
|
1
|
1
|