1: GO: Molecular Function [Display Chart]
12 input genes in category / 44 annotations before applied cutoff / 18661 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0070182
|
DNA polymerase binding
|
|
2.945E-5
|
1.296E-3
|
5.667E-3
|
1.296E-3
|
2
|
13
|
2
|
GO:0048257
|
3'-flap endonuclease activity
|
|
1.286E-3
|
2.829E-2
|
1.237E-1
|
5.657E-2
|
1
|
2
|
3
|
GO:0017108
|
5'-flap endonuclease activity
|
|
3.853E-3
|
4.073E-2
|
1.781E-1
|
1.695E-1
|
1
|
6
|
4
|
GO:0008821
|
crossover junction endodeoxyribonuclease activity
|
|
5.134E-3
|
4.073E-2
|
1.781E-1
|
2.259E-1
|
1
|
8
|
5
|
GO:0048256
|
flap endonuclease activity
|
|
5.134E-3
|
4.073E-2
|
1.781E-1
|
2.259E-1
|
1
|
8
|
6
|
GO:0016889
|
endodeoxyribonuclease activity, producing 3'-phosphomonoesters
|
|
6.413E-3
|
4.073E-2
|
1.781E-1
|
2.822E-1
|
1
|
10
|
7
|
GO:0061630
|
ubiquitin protein ligase activity
|
|
7.866E-3
|
4.073E-2
|
1.781E-1
|
3.461E-1
|
2
|
212
|
8
|
GO:0061659
|
ubiquitin-like protein ligase activity
|
|
8.227E-3
|
4.073E-2
|
1.781E-1
|
3.620E-1
|
2
|
217
|
9
|
GO:0016888
|
endodeoxyribonuclease activity, producing 5'-phosphomonoesters
|
|
8.330E-3
|
4.073E-2
|
1.781E-1
|
3.665E-1
|
1
|
13
|
Show 4 more annotations
|
2: GO: Biological Process [Display Chart]
12 input genes in category / 173 annotations before applied cutoff / 18623 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0036297
|
interstrand cross-link repair
|
|
1.183E-25
|
2.047E-23
|
1.174E-22
|
2.047E-23
|
10
|
44
|
2
|
GO:2000348
|
regulation of CD40 signaling pathway
|
|
7.979E-6
|
6.902E-4
|
3.957E-3
|
1.380E-3
|
2
|
7
|
3
|
GO:0023035
|
CD40 signaling pathway
|
|
1.367E-5
|
7.882E-4
|
4.519E-3
|
2.365E-3
|
2
|
9
|
4
|
GO:0008585
|
female gonad development
|
|
6.363E-5
|
2.122E-3
|
1.216E-2
|
1.101E-2
|
3
|
126
|
5
|
GO:0046545
|
development of primary female sexual characteristics
|
|
7.144E-5
|
2.122E-3
|
1.216E-2
|
1.236E-2
|
3
|
131
|
6
|
GO:0045589
|
regulation of regulatory T cell differentiation
|
|
8.730E-5
|
2.122E-3
|
1.216E-2
|
1.510E-2
|
2
|
22
|
7
|
GO:0046660
|
female sex differentiation
|
|
9.860E-5
|
2.122E-3
|
1.216E-2
|
1.706E-2
|
3
|
146
|
8
|
GO:0097150
|
neuronal stem cell population maintenance
|
|
1.042E-4
|
2.122E-3
|
1.216E-2
|
1.803E-2
|
2
|
24
|
9
|
GO:0045066
|
regulatory T cell differentiation
|
|
1.133E-4
|
2.122E-3
|
1.216E-2
|
1.959E-2
|
2
|
25
|
10
|
GO:0000732
|
strand displacement
|
|
1.226E-4
|
2.122E-3
|
1.216E-2
|
2.122E-2
|
2
|
26
|
11
|
GO:0006302
|
double-strand break repair
|
|
2.355E-4
|
3.704E-3
|
2.124E-2
|
4.074E-2
|
3
|
196
|
12
|
GO:0048854
|
brain morphogenesis
|
|
3.547E-4
|
5.114E-3
|
2.932E-2
|
6.136E-2
|
2
|
44
|
13
|
GO:0000075
|
cell cycle checkpoint
|
|
3.962E-4
|
5.273E-3
|
3.023E-2
|
6.855E-2
|
3
|
234
|
14
|
GO:0008406
|
gonad development
|
|
4.864E-4
|
5.943E-3
|
3.407E-2
|
8.415E-2
|
3
|
251
|
15
|
GO:0045137
|
development of primary sexual characteristics
|
|
5.153E-4
|
5.943E-3
|
3.407E-2
|
8.914E-2
|
3
|
256
|
16
|
GO:0006310
|
DNA recombination
|
|
5.825E-4
|
6.298E-3
|
3.611E-2
|
1.008E-1
|
3
|
267
|
17
|
GO:0007548
|
sex differentiation
|
|
8.906E-4
|
9.063E-3
|
5.196E-2
|
1.541E-1
|
3
|
309
|
18
|
GO:0001541
|
ovarian follicle development
|
|
1.002E-3
|
9.369E-3
|
5.372E-2
|
1.733E-1
|
2
|
74
|
19
|
GO:0000731
|
DNA synthesis involved in DNA repair
|
|
1.029E-3
|
9.369E-3
|
5.372E-2
|
1.780E-1
|
2
|
75
|
20
|
GO:0000724
|
double-strand break repair via homologous recombination
|
|
1.576E-3
|
1.326E-2
|
7.603E-2
|
2.727E-1
|
2
|
93
|
21
|
GO:0000725
|
recombinational repair
|
|
1.610E-3
|
1.326E-2
|
7.603E-2
|
2.785E-1
|
2
|
94
|
22
|
GO:0016236
|
macroautophagy
|
|
2.168E-3
|
1.651E-2
|
9.467E-2
|
3.750E-1
|
3
|
421
|
23
|
GO:0022602
|
ovulation cycle process
|
|
2.195E-3
|
1.651E-2
|
9.467E-2
|
3.798E-1
|
2
|
110
|
24
|
GO:0006289
|
nucleotide-excision repair
|
|
2.563E-3
|
1.712E-2
|
9.818E-2
|
4.434E-1
|
2
|
119
|
25
|
GO:1904431
|
positive regulation of t-circle formation
|
|
2.575E-3
|
1.712E-2
|
9.818E-2
|
4.455E-1
|
1
|
4
|
26
|
GO:0072429
|
response to intra-S DNA damage checkpoint signaling
|
|
2.575E-3
|
1.712E-2
|
9.818E-2
|
4.455E-1
|
1
|
4
|
27
|
GO:0048608
|
reproductive structure development
|
|
3.203E-3
|
1.712E-2
|
9.818E-2
|
5.541E-1
|
3
|
483
|
28
|
GO:0045580
|
regulation of T cell differentiation
|
|
3.235E-3
|
1.712E-2
|
9.818E-2
|
5.597E-1
|
2
|
134
|
29
|
GO:0061458
|
reproductive system development
|
|
3.279E-3
|
1.712E-2
|
9.818E-2
|
5.672E-1
|
3
|
487
|
30
|
GO:0098779
|
positive regulation of mitophagy in response to mitochondrial depolarization
|
|
3.379E-3
|
1.712E-2
|
9.818E-2
|
5.845E-1
|
2
|
137
|
31
|
GO:0098780
|
response to mitochondrial depolarisation
|
|
3.379E-3
|
1.712E-2
|
9.818E-2
|
5.845E-1
|
2
|
137
|
32
|
GO:0042698
|
ovulation cycle
|
|
3.427E-3
|
1.712E-2
|
9.818E-2
|
5.929E-1
|
2
|
138
|
33
|
GO:0000423
|
mitophagy
|
|
3.574E-3
|
1.712E-2
|
9.818E-2
|
6.184E-1
|
2
|
141
|
34
|
GO:0031052
|
chromosome breakage
|
|
3.860E-3
|
1.712E-2
|
9.818E-2
|
6.679E-1
|
1
|
6
|
35
|
GO:0072396
|
response to cell cycle checkpoint signaling
|
|
3.860E-3
|
1.712E-2
|
9.818E-2
|
6.679E-1
|
1
|
6
|
36
|
GO:0031049
|
programmed DNA elimination
|
|
3.860E-3
|
1.712E-2
|
9.818E-2
|
6.679E-1
|
1
|
6
|
37
|
GO:0072423
|
response to DNA damage checkpoint signaling
|
|
3.860E-3
|
1.712E-2
|
9.818E-2
|
6.679E-1
|
1
|
6
|
38
|
GO:0072402
|
response to DNA integrity checkpoint signaling
|
|
3.860E-3
|
1.712E-2
|
9.818E-2
|
6.679E-1
|
1
|
6
|
39
|
GO:0010792
|
DNA double-strand break processing involved in repair via single-strand annealing
|
|
3.860E-3
|
1.712E-2
|
9.818E-2
|
6.679E-1
|
1
|
6
|
40
|
GO:0000077
|
DNA damage checkpoint
|
|
4.247E-3
|
1.837E-2
|
1.053E-1
|
7.347E-1
|
2
|
154
|
41
|
GO:0045002
|
double-strand break repair via single-strand annealing
|
|
4.503E-3
|
1.855E-2
|
1.063E-1
|
7.789E-1
|
1
|
7
|
42
|
GO:1904429
|
regulation of t-circle formation
|
|
4.503E-3
|
1.855E-2
|
1.063E-1
|
7.789E-1
|
1
|
7
|
43
|
GO:0045619
|
regulation of lymphocyte differentiation
|
|
4.687E-3
|
1.886E-2
|
1.081E-1
|
8.109E-1
|
2
|
162
|
44
|
GO:0031570
|
DNA integrity checkpoint
|
|
4.801E-3
|
1.888E-2
|
1.082E-1
|
8.305E-1
|
2
|
164
|
45
|
GO:0090656
|
t-circle formation
|
|
5.144E-3
|
1.978E-2
|
1.134E-1
|
8.900E-1
|
1
|
8
|
46
|
GO:0019827
|
stem cell population maintenance
|
|
5.387E-3
|
2.026E-2
|
1.162E-1
|
9.319E-1
|
2
|
174
|
47
|
GO:0098727
|
maintenance of cell number
|
|
5.569E-3
|
2.050E-2
|
1.175E-1
|
9.634E-1
|
2
|
177
|
48
|
GO:1903046
|
meiotic cell cycle process
|
|
6.719E-3
|
2.422E-2
|
1.388E-1
|
1.000E0
|
2
|
195
|
49
|
GO:0000422
|
autophagy of mitochondrion
|
|
7.612E-3
|
2.634E-2
|
1.510E-1
|
1.000E0
|
2
|
208
|
50
|
GO:0061726
|
mitochondrion disassembly
|
|
7.612E-3
|
2.634E-2
|
1.510E-1
|
1.000E0
|
2
|
208
|
Show 45 more annotations
|
3: GO: Cellular Component [Display Chart]
12 input genes in category / 14 annotations before applied cutoff / 19061 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
GO:0043240
|
Fanconi anaemia nuclear complex
|
|
7.372E-24
|
1.032E-22
|
3.356E-22
|
1.032E-22
|
8
|
15
|
2
|
GO:0033557
|
Slx1-Slx4 complex
|
|
1.888E-3
|
8.809E-3
|
2.864E-2
|
2.643E-2
|
1
|
3
|
3
|
GO:0070522
|
ERCC4-ERCC1 complex
|
|
1.888E-3
|
8.809E-3
|
2.864E-2
|
2.643E-2
|
1
|
3
|
4
|
GO:0048476
|
Holliday junction resolvase complex
|
|
3.144E-3
|
1.100E-2
|
3.578E-2
|
4.402E-2
|
1
|
5
|
5
|
GO:0000109
|
nucleotide-excision repair complex
|
|
8.781E-3
|
2.459E-2
|
7.994E-2
|
1.229E-1
|
1
|
14
|
|
4: Human Phenotype [Display Chart]
12 input genes in category / 441 annotations before applied cutoff / 4707 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
HP:0005522
|
Pyridoxine-responsive sideroblastic anemia
|
|
5.173E-31
|
2.281E-28
|
1.521E-27
|
2.281E-28
|
12
|
20
|
2
|
HP:0010293
|
Aplasia/Hypoplasia of the uvula
|
|
1.207E-30
|
2.662E-28
|
1.775E-27
|
5.323E-28
|
12
|
21
|
3
|
HP:0010469
|
Absent testis
|
|
2.656E-30
|
3.904E-28
|
2.603E-27
|
1.171E-27
|
12
|
22
|
4
|
HP:0200005
|
Abnormal shape of the palpebral fissure
|
|
1.111E-29
|
9.795E-28
|
6.531E-27
|
4.897E-27
|
12
|
24
|
5
|
HP:0007874
|
Almond-shaped palpebral fissure
|
|
1.111E-29
|
9.795E-28
|
6.531E-27
|
4.897E-27
|
12
|
24
|
6
|
HP:0012848
|
Small intestinal stenosis
|
|
2.136E-29
|
1.345E-27
|
8.971E-27
|
9.418E-27
|
12
|
25
|
7
|
HP:0100867
|
Duodenal stenosis
|
|
2.136E-29
|
1.345E-27
|
8.971E-27
|
9.418E-27
|
12
|
25
|
8
|
HP:0001905
|
Congenital thrombocytopenia
|
|
7.139E-29
|
3.935E-27
|
2.624E-26
|
3.148E-26
|
12
|
27
|
9
|
HP:0100587
|
Abnormality of the preputium
|
|
2.131E-28
|
9.399E-27
|
6.267E-26
|
9.399E-26
|
12
|
29
|
10
|
HP:0004859
|
Amegakaryocytic thrombocytopenia
|
|
2.131E-28
|
9.399E-27
|
6.267E-26
|
9.399E-26
|
12
|
29
|
11
|
HP:0011133
|
Increased sensitivity to ionizing radiation
|
|
9.273E-28
|
3.718E-26
|
2.479E-25
|
4.089E-25
|
12
|
32
|
12
|
HP:0030976
|
Abnormal factor VIII activity
|
|
2.252E-27
|
7.094E-26
|
4.730E-25
|
9.931E-25
|
12
|
34
|
13
|
HP:0003125
|
Reduced factor VIII activity
|
|
2.252E-27
|
7.094E-26
|
4.730E-25
|
9.931E-25
|
12
|
34
|
14
|
HP:0003254
|
Abnormality of DNA repair
|
|
2.252E-27
|
7.094E-26
|
4.730E-25
|
9.931E-25
|
12
|
34
|
15
|
HP:0005510
|
Transient erythroblastopenia
|
|
3.427E-27
|
1.008E-25
|
6.717E-25
|
1.511E-24
|
12
|
35
|
16
|
HP:0002245
|
Meckel diverticulum
|
|
7.608E-27
|
2.097E-25
|
1.398E-24
|
3.355E-24
|
12
|
37
|
17
|
HP:0005505
|
Refractory anemia
|
|
1.112E-26
|
2.884E-25
|
1.923E-24
|
4.903E-24
|
12
|
38
|
18
|
HP:0011018
|
Abnormality of the cell cycle
|
|
2.294E-26
|
5.621E-25
|
3.748E-24
|
1.012E-23
|
12
|
40
|
19
|
HP:0000813
|
Bicornuate uterus
|
|
4.541E-26
|
1.054E-24
|
7.028E-24
|
2.003E-23
|
12
|
42
|
20
|
HP:0004810
|
Congenital hypoplastic anemia
|
|
1.181E-25
|
2.604E-24
|
1.736E-23
|
5.209E-23
|
12
|
45
|
21
|
HP:0100760
|
Clubbing of toes
|
|
1.598E-25
|
3.356E-24
|
2.237E-23
|
7.047E-23
|
12
|
46
|
22
|
HP:0000297
|
Facial hypotonia
|
|
4.986E-25
|
8.456E-24
|
5.638E-23
|
2.199E-22
|
12
|
50
|
23
|
HP:0002246
|
Abnormality of the duodenum
|
|
4.986E-25
|
8.456E-24
|
5.638E-23
|
2.199E-22
|
12
|
50
|
24
|
HP:0009619
|
Accessory phalanx of the thumb
|
|
4.986E-25
|
8.456E-24
|
5.638E-23
|
2.199E-22
|
12
|
50
|
25
|
HP:0001199
|
Triphalangeal thumb
|
|
4.986E-25
|
8.456E-24
|
5.638E-23
|
2.199E-22
|
12
|
50
|
26
|
HP:0004820
|
Acute myelomonocytic leukemia
|
|
4.986E-25
|
8.456E-24
|
5.638E-23
|
2.199E-22
|
12
|
50
|
27
|
HP:0001549
|
Abnormal ileum morphology
|
|
6.520E-25
|
1.027E-23
|
6.846E-23
|
2.875E-22
|
12
|
51
|
28
|
HP:0003220
|
Abnormality of chromosome stability
|
|
6.520E-25
|
1.027E-23
|
6.846E-23
|
2.875E-22
|
12
|
51
|
29
|
HP:0007565
|
Multiple cafe-au-lait spots
|
|
2.293E-24
|
3.487E-23
|
2.325E-22
|
1.011E-21
|
12
|
56
|
30
|
HP:0012324
|
Myeloid leukemia
|
|
2.905E-24
|
4.132E-23
|
2.755E-22
|
1.281E-21
|
12
|
57
|
31
|
HP:0001924
|
Sideroblastic anemia
|
|
2.905E-24
|
4.132E-23
|
2.755E-22
|
1.281E-21
|
12
|
57
|
32
|
HP:0005344
|
Abnormal carotid artery morphology
|
|
5.747E-24
|
7.920E-23
|
5.280E-22
|
2.534E-21
|
12
|
60
|
33
|
HP:0010989
|
Abnormality of the intrinsic pathway
|
|
1.096E-23
|
1.464E-22
|
9.764E-22
|
4.833E-21
|
12
|
63
|
34
|
HP:0040071
|
Abnormal morphology of ulna
|
|
2.991E-23
|
3.768E-22
|
2.512E-21
|
1.319E-20
|
12
|
68
|
35
|
HP:0003022
|
Hypoplasia of the ulna
|
|
2.991E-23
|
3.768E-22
|
2.512E-21
|
1.319E-20
|
12
|
68
|
36
|
HP:0004431
|
Complement deficiency
|
|
3.620E-23
|
4.315E-22
|
2.877E-21
|
1.596E-20
|
12
|
69
|
37
|
HP:0000072
|
Hydroureter
|
|
3.620E-23
|
4.315E-22
|
2.877E-21
|
1.596E-20
|
12
|
69
|
38
|
HP:0009778
|
Short thumb
|
|
1.274E-22
|
1.441E-21
|
9.605E-21
|
5.618E-20
|
12
|
76
|
39
|
HP:0006495
|
Aplasia/Hypoplasia of the ulna
|
|
1.274E-22
|
1.441E-21
|
9.605E-21
|
5.618E-20
|
12
|
76
|
40
|
HP:0001972
|
Macrocytic anemia
|
|
1.509E-22
|
1.623E-21
|
1.082E-20
|
6.656E-20
|
12
|
77
|
41
|
HP:0008572
|
External ear malformation
|
|
1.509E-22
|
1.623E-21
|
1.082E-20
|
6.656E-20
|
12
|
77
|
42
|
HP:0001217
|
Clubbing
|
|
1.784E-22
|
1.873E-21
|
1.249E-20
|
7.866E-20
|
12
|
78
|
43
|
HP:0002575
|
Tracheoesophageal fistula
|
|
2.103E-22
|
2.108E-21
|
1.405E-20
|
9.275E-20
|
12
|
79
|
44
|
HP:0002916
|
Abnormality of chromosome segregation
|
|
2.103E-22
|
2.108E-21
|
1.405E-20
|
9.275E-20
|
12
|
79
|
45
|
HP:0001908
|
Hypoplastic anemia
|
|
3.977E-22
|
3.898E-21
|
2.599E-20
|
1.754E-19
|
12
|
83
|
46
|
HP:0012745
|
Short palpebral fissure
|
|
4.640E-22
|
4.449E-21
|
2.966E-20
|
2.046E-19
|
12
|
84
|
47
|
HP:0005528
|
Bone marrow hypocellularity
|
|
6.279E-22
|
5.769E-21
|
3.847E-20
|
2.769E-19
|
12
|
86
|
48
|
HP:0006501
|
Aplasia/Hypoplasia of the radius
|
|
6.279E-22
|
5.769E-21
|
3.847E-20
|
2.769E-19
|
12
|
86
|
49
|
HP:0000453
|
Choanal atresia
|
|
8.434E-22
|
7.591E-21
|
5.061E-20
|
3.719E-19
|
12
|
88
|
50
|
HP:0009821
|
Forearm undergrowth
|
|
9.749E-22
|
8.598E-21
|
5.733E-20
|
4.299E-19
|
12
|
89
|
Show 45 more annotations
|
5: Mouse Phenotype [Display Chart]
11 input genes in category / 314 annotations before applied cutoff / 10355 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
MP:0004030
|
induced chromosome breakage
|
|
4.748E-14
|
1.491E-11
|
9.434E-11
|
1.491E-11
|
6
|
25
|
2
|
MP:0004028
|
chromosome breakage
|
|
1.881E-13
|
2.953E-11
|
1.869E-10
|
5.907E-11
|
7
|
72
|
3
|
MP:0001131
|
abnormal ovarian follicle morphology
|
|
4.571E-12
|
4.784E-10
|
3.028E-9
|
1.435E-9
|
8
|
214
|
4
|
MP:0008866
|
chromosomal instability
|
|
7.040E-12
|
4.980E-10
|
3.151E-9
|
2.211E-9
|
7
|
119
|
5
|
MP:0010094
|
abnormal chromosome stability
|
|
7.930E-12
|
4.980E-10
|
3.151E-9
|
2.490E-9
|
7
|
121
|
6
|
MP:0001126
|
abnormal ovary morphology
|
|
1.348E-10
|
7.052E-9
|
4.463E-8
|
4.231E-8
|
8
|
326
|
7
|
MP:0013324
|
abnormal female reproductive gland morphology
|
|
3.112E-10
|
1.396E-8
|
8.835E-8
|
9.772E-8
|
8
|
362
|
8
|
MP:0001127
|
small ovary
|
|
3.355E-9
|
1.235E-7
|
7.815E-7
|
1.053E-6
|
6
|
148
|
9
|
MP:0009209
|
abnormal internal female genitalia morphology
|
|
3.690E-9
|
1.235E-7
|
7.815E-7
|
1.159E-6
|
8
|
494
|
10
|
MP:0002209
|
decreased germ cell number
|
|
3.933E-9
|
1.235E-7
|
7.815E-7
|
1.235E-6
|
8
|
498
|
11
|
MP:0004853
|
abnormal ovary size
|
|
7.468E-9
|
2.132E-7
|
1.349E-6
|
2.345E-6
|
6
|
169
|
12
|
MP:0002216
|
abnormal seminiferous tubule morphology
|
|
1.314E-8
|
3.438E-7
|
2.176E-6
|
4.126E-6
|
7
|
347
|
13
|
MP:0008391
|
abnormal primordial germ cell morphology
|
|
4.995E-8
|
1.206E-6
|
7.635E-6
|
1.568E-5
|
4
|
38
|
14
|
MP:0002673
|
abnormal sperm number
|
|
5.703E-8
|
1.279E-6
|
8.094E-6
|
1.791E-5
|
7
|
429
|
15
|
MP:0004901
|
decreased male germ cell number
|
|
7.341E-8
|
1.492E-6
|
9.445E-6
|
2.305E-5
|
7
|
445
|
16
|
MP:0002687
|
oligozoospermia
|
|
7.605E-8
|
1.492E-6
|
9.445E-6
|
2.388E-5
|
6
|
249
|
17
|
MP:0008871
|
abnormal ovarian follicle number
|
|
1.517E-7
|
2.802E-6
|
1.773E-5
|
4.764E-5
|
5
|
135
|
18
|
MP:0001149
|
testicular hyperplasia
|
|
2.121E-7
|
3.701E-6
|
2.342E-5
|
6.661E-5
|
4
|
54
|
19
|
MP:0008943
|
increased sensitivity to induced cell death
|
|
6.733E-7
|
1.113E-5
|
7.042E-5
|
2.114E-4
|
5
|
182
|
20
|
MP:0003111
|
abnormal cell nucleus morphology
|
|
9.010E-7
|
1.415E-5
|
8.951E-5
|
2.829E-4
|
5
|
193
|
21
|
MP:0003702
|
abnormal chromosome morphology
|
|
1.046E-6
|
1.564E-5
|
9.898E-5
|
3.285E-4
|
4
|
80
|
22
|
MP:0001148
|
enlarged testis
|
|
1.336E-6
|
1.906E-5
|
1.206E-4
|
4.194E-4
|
4
|
85
|
23
|
MP:0014040
|
increased cellular sensitivity to DNA damaging agents
|
|
2.288E-6
|
3.124E-5
|
1.977E-4
|
7.185E-4
|
3
|
26
|
24
|
MP:0001130
|
abnormal ovarian folliculogenesis
|
|
3.119E-6
|
4.081E-5
|
2.582E-4
|
9.794E-4
|
4
|
105
|
25
|
MP:0008942
|
abnormal induced cell death
|
|
3.564E-6
|
4.477E-5
|
2.833E-4
|
1.119E-3
|
5
|
255
|
26
|
MP:0004029
|
spontaneous chromosome breakage
|
|
4.350E-6
|
5.253E-5
|
3.324E-4
|
1.366E-3
|
3
|
32
|
27
|
MP:0008392
|
decreased primordial germ cell number
|
|
5.730E-6
|
6.664E-5
|
4.217E-4
|
1.799E-3
|
3
|
35
|
28
|
MP:0002016
|
ovary cysts
|
|
2.270E-5
|
2.546E-4
|
1.611E-3
|
7.129E-3
|
3
|
55
|
29
|
MP:0002682
|
decreased mature ovarian follicle number
|
|
3.260E-5
|
3.529E-4
|
2.233E-3
|
1.024E-2
|
3
|
62
|
30
|
MP:0005158
|
ovary hypoplasia
|
|
3.679E-5
|
3.726E-4
|
2.358E-3
|
1.155E-2
|
2
|
9
|
31
|
MP:0002776
|
Sertoli cell hyperplasia
|
|
3.679E-5
|
3.726E-4
|
2.358E-3
|
1.155E-2
|
2
|
9
|
32
|
MP:0009364
|
abnormal mature ovarian follicle morphology
|
|
4.497E-5
|
4.413E-4
|
2.793E-3
|
1.412E-2
|
3
|
69
|
33
|
MP:0003179
|
thrombocytopenia
|
|
5.819E-5
|
5.537E-4
|
3.504E-3
|
1.827E-2
|
4
|
220
|
34
|
MP:0002784
|
abnormal Sertoli cell morphology
|
|
6.010E-5
|
5.550E-4
|
3.512E-3
|
1.887E-2
|
3
|
76
|
35
|
MP:0008390
|
abnormal primordial germ cell proliferation
|
|
7.952E-5
|
7.134E-4
|
4.514E-3
|
2.497E-2
|
2
|
13
|
36
|
MP:0001154
|
seminiferous tubule degeneration
|
|
1.207E-4
|
1.053E-3
|
6.664E-3
|
3.791E-2
|
3
|
96
|
37
|
MP:0001923
|
reduced female fertility
|
|
1.466E-4
|
1.244E-3
|
7.872E-3
|
4.602E-2
|
4
|
279
|
38
|
MP:0008873
|
increased physiological sensitivity to xenobiotic
|
|
1.591E-4
|
1.315E-3
|
8.322E-3
|
4.997E-2
|
4
|
285
|
39
|
MP:0010288
|
increased gland tumor incidence
|
|
1.725E-4
|
1.382E-3
|
8.746E-3
|
5.416E-2
|
4
|
291
|
40
|
MP:0011750
|
abnormal seminiferous tubule epithelium morphology
|
|
1.761E-4
|
1.382E-3
|
8.746E-3
|
5.528E-2
|
3
|
109
|
41
|
MP:0011898
|
abnormal platelet cell number
|
|
1.890E-4
|
1.426E-3
|
9.027E-3
|
5.936E-2
|
4
|
298
|
42
|
MP:0002679
|
abnormal corpus luteum morphology
|
|
1.908E-4
|
1.426E-3
|
9.027E-3
|
5.991E-2
|
3
|
112
|
43
|
MP:0008058
|
abnormal DNA repair
|
|
2.640E-4
|
1.928E-3
|
1.220E-2
|
8.290E-2
|
3
|
125
|
44
|
MP:0020363
|
abnormal germ cell physiology
|
|
3.037E-4
|
2.167E-3
|
1.372E-2
|
9.537E-2
|
2
|
25
|
45
|
MP:0001935
|
decreased litter size
|
|
3.318E-4
|
2.316E-3
|
1.465E-2
|
1.042E-1
|
4
|
345
|
46
|
MP:0001933
|
abnormal litter size
|
|
3.702E-4
|
2.527E-3
|
1.599E-2
|
1.162E-1
|
4
|
355
|
47
|
MP:0002590
|
increased mean corpuscular volume
|
|
4.170E-4
|
2.786E-3
|
1.763E-2
|
1.309E-1
|
3
|
146
|
48
|
MP:0008280
|
abnormal male germ cell apoptosis
|
|
4.693E-4
|
3.070E-3
|
1.943E-2
|
1.474E-1
|
3
|
152
|
49
|
MP:0004720
|
abnormal platelet morphology
|
|
5.721E-4
|
3.666E-3
|
2.320E-2
|
1.796E-1
|
4
|
398
|
50
|
MP:0013662
|
decreased myeloid cell number
|
|
6.765E-4
|
4.248E-3
|
2.689E-2
|
2.124E-1
|
4
|
416
|
Show 45 more annotations
|
6: Domain [Display Chart]
12 input genes in category / 76 annotations before applied cutoff / 18735 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
PF11793
|
FANCL C
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
2
|
IPR029305
|
FANCI S1-cap
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
3
|
PF09765
|
WD-3
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
4
|
IPR029310
|
FANCI HD1
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
5
|
PF16756
|
PALB2 WD40
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
6
|
IPR031729
|
Fanconi A N
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
7
|
IPR029312
|
FANCI HD2
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
8
|
PF14631
|
FancD2
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
9
|
IPR029313
|
FANCI S3
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
10
|
PF14674
|
FANCI S1-cap
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
11
|
IPR029448
|
FANCD2
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
12
|
IPR025825
|
FANCF
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
13
|
IPR019162
|
FancL WD-rpt cont dom
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
14
|
IPR029308
|
FANCI S1
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
15
|
IPR026848
|
Fancl
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
16
|
IPR021025
|
Fanconi anaemia gr E prot C
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
17
|
PD321645
|
PD321645
|
ProDom
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
18
|
IPR026850
|
FANCL C
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
19
|
PF14675
|
FANCI S1
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
20
|
IPR033333
|
FANCB
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
21
|
IPR031920
|
PALB2 WD40
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
22
|
PF14680
|
FANCI HD2
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
23
|
PF14677
|
FANCI S3
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
24
|
PF02106
|
Fanconi C
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
25
|
PF15865
|
Fanconi A N
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
26
|
PF03511
|
Fanconi A
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
27
|
PF14676
|
FANCI S2
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
28
|
IPR026171
|
FANCI
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
29
|
IPR018574
|
Structure-sp endonuc su Slx4
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
30
|
IPR003516
|
FANCA
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
31
|
PF14678
|
FANCI S4
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
32
|
IPR029315
|
FANCI S2
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
33
|
PF09494
|
Slx4
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
34
|
IPR000686
|
Fanconi
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
35
|
PF14679
|
FANCI HD1
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
36
|
PF11510
|
FA FANCE
|
Pfam
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
37
|
IPR029314
|
FANCI S4
|
InterPro
|
6.405E-4
|
1.316E-3
|
6.466E-3
|
4.868E-2
|
1
|
1
|
38
|
IPR013020
|
DNA helicase DNA-repair Rad3
|
InterPro
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
39
|
PF13307
|
Helicase C 2
|
Pfam
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
40
|
SM00491
|
HELICc2
|
SMART
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
41
|
SM00488
|
DEXDc2
|
SMART
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
42
|
PS51193
|
HELICASE ATP BIND 2
|
PROSITE
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
43
|
IPR014013
|
Helic SF1/SF2 ATP-bd DinG/Rad3
|
InterPro
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
44
|
IPR006555
|
ATP-dep Helicase C
|
InterPro
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
45
|
PF06733
|
DEAD 2
|
Pfam
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
46
|
IPR010614
|
DEAD 2
|
InterPro
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
47
|
IPR006554
|
Helicase-like DEXD c2
|
InterPro
|
2.560E-3
|
4.139E-3
|
2.034E-2
|
1.945E-1
|
1
|
4
|
48
|
IPR009075
|
AcylCo DH/oxidase C
|
InterPro
|
1.020E-2
|
1.616E-2
|
7.939E-2
|
7.754E-1
|
1
|
16
|
49
|
IPR002464
|
DNA/RNA helicase DEAH CS
|
InterPro
|
2.220E-2
|
3.443E-2
|
1.692E-1
|
1.000E0
|
1
|
35
|
50
|
PS00690
|
DEAH ATP HELICASE
|
PROSITE
|
2.408E-2
|
3.660E-2
|
1.799E-1
|
1.000E0
|
1
|
38
|
Show 45 more annotations
|
7: Pathway [Display Chart]
12 input genes in category / 26 annotations before applied cutoff / 12450 genes in category
|
8: Pubmed [Display Chart]
12 input genes in category / 1022 annotations before applied cutoff / 38193 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
20301575
|
Fanconi Anemia
|
Pubmed
|
1.464E-41
|
1.496E-38
|
1.123E-37
|
1.496E-38
|
12
|
21
|
2
|
20301753
|
Esophageal Atresia/Tracheoesophageal Fistula Overview
|
Pubmed
|
3.221E-41
|
1.646E-38
|
1.236E-37
|
3.292E-38
|
12
|
22
|
3
|
27986371
|
Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.
|
Pubmed
|
3.303E-31
|
1.125E-28
|
8.448E-28
|
3.376E-28
|
9
|
13
|
4
|
19536649
|
The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.
|
Pubmed
|
2.312E-30
|
5.907E-28
|
4.434E-27
|
2.363E-27
|
9
|
15
|
5
|
15502827
|
X-linked inheritance of Fanconi anemia complementation group B.
|
Pubmed
|
4.411E-30
|
9.017E-28
|
6.769E-27
|
4.508E-27
|
8
|
8
|
6
|
16116422
|
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
|
Pubmed
|
2.183E-27
|
3.718E-25
|
2.791E-24
|
2.231E-24
|
8
|
12
|
7
|
19690177
|
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.
|
Pubmed
|
9.302E-27
|
1.358E-24
|
1.020E-23
|
9.506E-24
|
9
|
31
|
8
|
22705371
|
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
|
Pubmed
|
5.551E-25
|
7.091E-23
|
5.323E-22
|
5.673E-22
|
8
|
20
|
9
|
17396147
|
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.
|
Pubmed
|
1.213E-24
|
1.239E-22
|
9.303E-22
|
1.239E-21
|
7
|
9
|
10
|
23303816
|
Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1.
|
Pubmed
|
1.213E-24
|
1.239E-22
|
9.303E-22
|
1.239E-21
|
7
|
9
|
11
|
12973351
|
A novel ubiquitin ligase is deficient in Fanconi anemia.
|
Pubmed
|
2.667E-23
|
2.478E-21
|
1.860E-20
|
2.725E-20
|
7
|
12
|
12
|
12649160
|
Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems.
|
Pubmed
|
2.144E-22
|
1.581E-20
|
1.187E-19
|
2.191E-19
|
6
|
6
|
13
|
12093742
|
FANCE: the link between Fanconi anaemia complex assembly and activity.
|
Pubmed
|
2.144E-22
|
1.581E-20
|
1.187E-19
|
2.191E-19
|
6
|
6
|
14
|
17289582
|
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
|
Pubmed
|
2.166E-22
|
1.581E-20
|
1.187E-19
|
2.214E-19
|
7
|
15
|
15
|
20347428
|
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
|
Pubmed
|
3.850E-22
|
2.623E-20
|
1.969E-19
|
3.935E-19
|
7
|
16
|
16
|
22343915
|
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.
|
Pubmed
|
1.071E-21
|
6.840E-20
|
5.135E-19
|
1.094E-18
|
7
|
18
|
17
|
24451376
|
The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.
|
Pubmed
|
1.501E-21
|
8.521E-20
|
6.397E-19
|
1.534E-18
|
6
|
7
|
18
|
16720839
|
Evidence for subcomplexes in the Fanconi anemia pathway.
|
Pubmed
|
1.501E-21
|
8.521E-20
|
6.397E-19
|
1.534E-18
|
6
|
7
|
19
|
18550849
|
HES1 is a novel interactor of the Fanconi anemia core complex.
|
Pubmed
|
4.500E-20
|
2.421E-18
|
1.817E-17
|
4.599E-17
|
6
|
10
|
20
|
12724401
|
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
|
Pubmed
|
1.980E-19
|
1.012E-17
|
7.594E-17
|
2.023E-16
|
6
|
12
|
21
|
16474167
|
The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.
|
Pubmed
|
1.170E-18
|
4.598E-17
|
3.452E-16
|
1.196E-15
|
5
|
5
|
22
|
9382107
|
Evidence for at least eight Fanconi anemia genes.
|
Pubmed
|
1.170E-18
|
4.598E-17
|
3.452E-16
|
1.196E-15
|
5
|
5
|
23
|
17082180
|
Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.
|
Pubmed
|
1.170E-18
|
4.598E-17
|
3.452E-16
|
1.196E-15
|
5
|
5
|
24
|
11157805
|
Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway.
|
Pubmed
|
1.170E-18
|
4.598E-17
|
3.452E-16
|
1.196E-15
|
5
|
5
|
25
|
15262960
|
The Fanconi anemia gene product FANCF is a flexible adaptor protein.
|
Pubmed
|
1.170E-18
|
4.598E-17
|
3.452E-16
|
1.196E-15
|
5
|
5
|
26
|
12239156
|
The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC.
|
Pubmed
|
1.170E-18
|
4.598E-17
|
3.452E-16
|
1.196E-15
|
5
|
5
|
27
|
15082718
|
The Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartments.
|
Pubmed
|
2.456E-17
|
9.296E-16
|
6.978E-15
|
2.510E-14
|
5
|
7
|
28
|
18950845
|
Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
|
Pubmed
|
2.300E-16
|
8.339E-15
|
6.260E-14
|
2.350E-13
|
7
|
89
|
29
|
19714462
|
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
|
Pubmed
|
2.366E-16
|
8.339E-15
|
6.260E-14
|
2.418E-13
|
6
|
33
|
30
|
16889989
|
alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.
|
Pubmed
|
2.873E-16
|
9.711E-15
|
7.290E-14
|
2.936E-13
|
6
|
34
|
31
|
19321451
|
The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling.
|
Pubmed
|
2.946E-16
|
9.711E-15
|
7.290E-14
|
3.010E-13
|
5
|
10
|
32
|
20347429
|
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.
|
Pubmed
|
2.339E-15
|
7.469E-14
|
5.607E-13
|
2.390E-12
|
5
|
14
|
33
|
27760317
|
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
|
Pubmed
|
5.101E-15
|
1.542E-13
|
1.158E-12
|
5.213E-12
|
5
|
16
|
34
|
16127171
|
FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.
|
Pubmed
|
5.584E-15
|
1.542E-13
|
1.158E-12
|
5.707E-12
|
4
|
4
|
35
|
11063725
|
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.
|
Pubmed
|
5.584E-15
|
1.542E-13
|
1.158E-12
|
5.707E-12
|
4
|
4
|
36
|
11750104
|
Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells.
|
Pubmed
|
5.584E-15
|
1.542E-13
|
1.158E-12
|
5.707E-12
|
4
|
4
|
37
|
12444097
|
Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants.
|
Pubmed
|
5.584E-15
|
1.542E-13
|
1.158E-12
|
5.707E-12
|
4
|
4
|
38
|
20496165
|
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
|
Pubmed
|
2.327E-14
|
6.225E-13
|
4.673E-12
|
2.379E-11
|
6
|
68
|
39
|
19064572
|
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
|
Pubmed
|
2.375E-14
|
6.225E-13
|
4.673E-12
|
2.428E-11
|
7
|
170
|
40
|
22653977
|
FANCL ubiquitinates β-catenin and enhances its nuclear function.
|
Pubmed
|
2.792E-14
|
7.132E-13
|
5.354E-12
|
2.853E-11
|
4
|
5
|
41
|
26277624
|
Analysis of a FANCE Splice Isoform in Regard to DNA Repair.
|
Pubmed
|
8.373E-14
|
1.945E-12
|
1.460E-11
|
8.557E-11
|
4
|
6
|
42
|
18212739
|
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.
|
Pubmed
|
8.373E-14
|
1.945E-12
|
1.460E-11
|
8.557E-11
|
4
|
6
|
43
|
20450923
|
Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance.
|
Pubmed
|
8.373E-14
|
1.945E-12
|
1.460E-11
|
8.557E-11
|
4
|
6
|
44
|
20518497
|
Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.
|
Pubmed
|
8.373E-14
|
1.945E-12
|
1.460E-11
|
8.557E-11
|
4
|
6
|
45
|
22266823
|
Regulation of Rev1 by the Fanconi anemia core complex.
|
Pubmed
|
1.953E-13
|
4.248E-12
|
3.189E-11
|
1.996E-10
|
4
|
7
|
46
|
24469828
|
The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression.
|
Pubmed
|
1.953E-13
|
4.248E-12
|
3.189E-11
|
1.996E-10
|
4
|
7
|
47
|
24910428
|
Modularized functions of the Fanconi anemia core complex.
|
Pubmed
|
1.953E-13
|
4.248E-12
|
3.189E-11
|
1.996E-10
|
4
|
7
|
48
|
19995904
|
DNA polymerase POLN participates in cross-link repair and homologous recombination.
|
Pubmed
|
3.906E-13
|
8.317E-12
|
6.244E-11
|
3.992E-10
|
4
|
8
|
49
|
26269593
|
Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).
|
Pubmed
|
7.030E-13
|
1.466E-11
|
1.101E-10
|
7.185E-10
|
4
|
9
|
50
|
26625197
|
Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response.
|
Pubmed
|
1.841E-12
|
3.762E-11
|
2.824E-10
|
1.881E-9
|
4
|
11
|
Show 45 more annotations
|
9: Interaction [Display Chart]
12 input genes in category / 1871 annotations before applied cutoff / 17703 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
int:FAAP20
|
FAAP20 interactions
|
|
4.206E-22
|
7.869E-19
|
6.383E-18
|
7.869E-19
|
8
|
21
|
2
|
int:FANCM
|
FANCM interactions
|
|
1.967E-19
|
1.515E-16
|
1.229E-15
|
3.680E-16
|
8
|
41
|
3
|
int:FANCL
|
FANCL interactions
|
|
2.429E-19
|
1.515E-16
|
1.229E-15
|
4.545E-16
|
8
|
42
|
4
|
int:FANCB
|
FANCB interactions
|
|
5.667E-19
|
2.651E-16
|
2.150E-15
|
1.060E-15
|
7
|
20
|
5
|
int:FANCF
|
FANCF interactions
|
|
1.246E-18
|
4.663E-16
|
3.783E-15
|
2.332E-15
|
7
|
22
|
6
|
int:FANCC
|
FANCC interactions
|
|
1.546E-18
|
4.820E-16
|
3.910E-15
|
2.892E-15
|
8
|
52
|
7
|
int:FANCE
|
FANCE interactions
|
|
6.481E-18
|
1.516E-15
|
1.229E-14
|
1.213E-14
|
7
|
27
|
8
|
int:CENPS
|
CENPS interactions
|
|
6.481E-18
|
1.516E-15
|
1.229E-14
|
1.213E-14
|
7
|
27
|
9
|
int:FANCG
|
FANCG interactions
|
|
3.449E-17
|
7.171E-15
|
5.817E-14
|
6.454E-14
|
8
|
75
|
10
|
int:FAAP100
|
FAAP100 interactions
|
|
1.962E-16
|
3.670E-14
|
2.977E-13
|
3.670E-13
|
7
|
42
|
11
|
int:FANCA
|
FANCA interactions
|
|
1.116E-15
|
1.899E-13
|
1.540E-12
|
2.089E-12
|
8
|
114
|
12
|
int:CENPX
|
CENPX interactions
|
|
2.173E-15
|
3.388E-13
|
2.748E-12
|
4.065E-12
|
6
|
23
|
13
|
int:POLN
|
POLN interactions
|
|
1.276E-14
|
1.836E-12
|
1.489E-11
|
2.386E-11
|
6
|
30
|
14
|
int:HES1
|
HES1 interactions
|
|
5.509E-13
|
7.363E-11
|
5.973E-10
|
1.031E-9
|
6
|
54
|
15
|
int:SPTA1
|
SPTA1 interactions
|
|
1.308E-12
|
1.632E-10
|
1.324E-9
|
2.448E-9
|
6
|
62
|
16
|
int:CTBP1
|
CTBP1 interactions
|
|
1.435E-11
|
1.678E-9
|
1.361E-8
|
2.685E-8
|
7
|
197
|
17
|
int:FAAP24
|
FAAP24 interactions
|
|
4.664E-10
|
5.134E-8
|
4.164E-7
|
8.727E-7
|
4
|
19
|
18
|
int:FOXF1
|
FOXF1 interactions
|
|
1.795E-9
|
1.865E-7
|
1.513E-6
|
3.358E-6
|
4
|
26
|
19
|
int:BRCA2
|
BRCA2 interactions
|
|
5.622E-9
|
5.536E-7
|
4.490E-6
|
1.052E-5
|
5
|
107
|
20
|
int:ERCC4
|
ERCC4 interactions
|
|
7.896E-9
|
7.387E-7
|
5.992E-6
|
1.477E-5
|
4
|
37
|
21
|
int:CAPN1
|
CAPN1 interactions
|
|
1.685E-8
|
1.501E-6
|
1.218E-5
|
3.153E-5
|
5
|
133
|
22
|
int:TOP3A
|
TOP3A interactions
|
|
5.034E-8
|
4.281E-6
|
3.473E-5
|
9.419E-5
|
4
|
58
|
23
|
int:SPTAN1
|
SPTAN1 interactions
|
|
2.186E-7
|
1.778E-5
|
1.442E-4
|
4.090E-4
|
5
|
222
|
24
|
int:PCNA
|
PCNA interactions
|
|
1.335E-6
|
1.041E-4
|
8.442E-4
|
2.498E-3
|
5
|
320
|
25
|
int:BLM
|
BLM interactions
|
|
1.766E-6
|
1.321E-4
|
1.072E-3
|
3.303E-3
|
4
|
140
|
26
|
int:RAD51
|
RAD51 interactions
|
|
1.922E-6
|
1.383E-4
|
1.122E-3
|
3.595E-3
|
4
|
143
|
27
|
int:UBE2T
|
UBE2T interactions
|
|
2.318E-6
|
1.595E-4
|
1.294E-3
|
4.337E-3
|
3
|
40
|
28
|
int:MSH2
|
MSH2 interactions
|
|
2.387E-6
|
1.595E-4
|
1.294E-3
|
4.467E-3
|
4
|
151
|
29
|
int:FAN1
|
FAN1 interactions
|
|
3.794E-6
|
2.448E-4
|
1.986E-3
|
7.099E-3
|
3
|
47
|
30
|
int:MMS19
|
MMS19 interactions
|
|
7.289E-6
|
4.546E-4
|
3.688E-3
|
1.364E-2
|
4
|
200
|
31
|
int:RPA1
|
RPA1 interactions
|
|
1.150E-5
|
6.940E-4
|
5.629E-3
|
2.151E-2
|
5
|
497
|
32
|
int:SAMD3
|
SAMD3 interactions
|
|
1.512E-5
|
8.771E-4
|
7.115E-3
|
2.830E-2
|
2
|
9
|
33
|
int:NOTCH1
|
NOTCH1 interactions
|
|
1.547E-5
|
8.771E-4
|
7.115E-3
|
2.894E-2
|
4
|
242
|
34
|
int:GGN
|
GGN interactions
|
|
1.890E-5
|
9.867E-4
|
8.004E-3
|
3.536E-2
|
2
|
10
|
35
|
int:PRDX3
|
PRDX3 interactions
|
|
1.898E-5
|
9.867E-4
|
8.004E-3
|
3.552E-2
|
3
|
80
|
36
|
int:FANCI
|
FANCI interactions
|
|
1.898E-5
|
9.867E-4
|
8.004E-3
|
3.552E-2
|
3
|
80
|
37
|
int:HELQ
|
HELQ interactions
|
|
2.770E-5
|
1.401E-3
|
1.136E-2
|
5.182E-2
|
2
|
12
|
38
|
int:KRT1
|
KRT1 interactions
|
|
3.385E-5
|
1.667E-3
|
1.352E-2
|
6.333E-2
|
3
|
97
|
39
|
int:NBN
|
NBN interactions
|
|
3.490E-5
|
1.674E-3
|
1.358E-2
|
6.531E-2
|
3
|
98
|
40
|
int:PIAS4
|
PIAS4 interactions
|
|
4.414E-5
|
2.065E-3
|
1.675E-2
|
8.258E-2
|
3
|
106
|
41
|
int:DCLRE1B
|
DCLRE1B interactions
|
|
5.028E-5
|
2.294E-3
|
1.861E-2
|
9.407E-2
|
2
|
16
|
42
|
int:IKZF3
|
IKZF3 interactions
|
|
5.203E-5
|
2.318E-3
|
1.880E-2
|
9.734E-2
|
3
|
112
|
43
|
int:CDK1
|
CDK1 interactions
|
|
6.131E-5
|
2.668E-3
|
2.164E-2
|
1.147E-1
|
4
|
344
|
44
|
int:AZIN1
|
AZIN1 interactions
|
|
6.406E-5
|
2.724E-3
|
2.210E-2
|
1.199E-1
|
2
|
18
|
45
|
int:ATR
|
ATR interactions
|
|
7.047E-5
|
2.930E-3
|
2.377E-2
|
1.318E-1
|
3
|
124
|
46
|
int:MRE11
|
MRE11 interactions
|
|
9.478E-5
|
3.844E-3
|
3.118E-2
|
1.773E-1
|
3
|
137
|
47
|
int:IL6R
|
IL6R interactions
|
|
9.657E-5
|
3.844E-3
|
3.118E-2
|
1.807E-1
|
2
|
22
|
48
|
int:RMI1
|
RMI1 interactions
|
|
1.153E-4
|
4.494E-3
|
3.646E-2
|
2.157E-1
|
2
|
24
|
49
|
int:XRCC3
|
XRCC3 interactions
|
|
1.447E-4
|
5.481E-3
|
4.446E-2
|
2.706E-1
|
3
|
158
|
50
|
int:REV1
|
REV1 interactions
|
|
1.465E-4
|
5.481E-3
|
4.446E-2
|
2.740E-1
|
2
|
27
|
Show 45 more annotations
|
10: Cytoband [Display Chart]
12 input genes in category / 12 annotations before applied cutoff / 34661 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
17q22.2
|
17q22.2
|
|
3.462E-4
|
4.154E-3
|
1.289E-2
|
4.155E-3
|
1
|
1
|
2
|
6p22-p21
|
6p22-p21
|
|
6.923E-4
|
4.154E-3
|
1.289E-2
|
8.308E-3
|
1
|
2
|
3
|
3p26
|
3p26
|
|
3.112E-3
|
1.244E-2
|
3.861E-2
|
3.734E-2
|
1
|
9
|
4
|
9q22.3
|
9q22.3
|
|
4.147E-3
|
1.244E-2
|
3.861E-2
|
4.977E-2
|
1
|
12
|
5
|
9p13
|
9p13
|
|
7.935E-3
|
1.904E-2
|
5.910E-2
|
9.522E-2
|
1
|
23
|
6
|
2p16.1
|
2p16.1
|
|
1.102E-2
|
2.154E-2
|
6.684E-2
|
1.323E-1
|
1
|
32
|
7
|
16p12.2
|
16p12.2
|
|
1.274E-2
|
2.154E-2
|
6.684E-2
|
1.528E-1
|
1
|
37
|
8
|
Xp22.2
|
Xp22.2
|
|
1.445E-2
|
2.154E-2
|
6.684E-2
|
1.734E-1
|
1
|
42
|
9
|
11p15
|
11p15
|
|
1.615E-2
|
2.154E-2
|
6.684E-2
|
1.938E-1
|
1
|
47
|
10
|
16q24.3
|
16q24.3
|
|
1.922E-2
|
2.306E-2
|
7.157E-2
|
2.306E-1
|
1
|
56
|
11
|
15q26.1
|
15q26.1
|
|
2.126E-2
|
2.319E-2
|
7.197E-2
|
2.551E-1
|
1
|
62
|
Show 6 more annotations
|
11: Transcription Factor Binding Site [Display Chart]
7 input genes in category / 37 annotations before applied cutoff / 9770 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
V$E2F1 Q6
|
V$E2F1 Q6
|
|
2.072E-4
|
1.452E-3
|
6.102E-3
|
7.667E-3
|
3
|
181
|
2
|
V$E2F1DP2 01
|
V$E2F1DP2 01
|
|
2.176E-4
|
1.452E-3
|
6.102E-3
|
8.050E-3
|
3
|
184
|
3
|
V$E2F1DP1 01
|
V$E2F1DP1 01
|
|
2.176E-4
|
1.452E-3
|
6.102E-3
|
8.050E-3
|
3
|
184
|
4
|
V$E2F4DP2 01
|
V$E2F4DP2 01
|
|
2.176E-4
|
1.452E-3
|
6.102E-3
|
8.050E-3
|
3
|
184
|
5
|
V$E2F 02
|
V$E2F 02
|
|
2.176E-4
|
1.452E-3
|
6.102E-3
|
8.050E-3
|
3
|
184
|
6
|
V$E2F4DP1 01
|
V$E2F4DP1 01
|
|
2.355E-4
|
1.452E-3
|
6.102E-3
|
8.714E-3
|
3
|
189
|
7
|
SGCGSSAAA V$E2F1DP2 01
|
SGCGSSAAA V$E2F1DP2 01
|
|
3.585E-3
|
1.895E-2
|
7.962E-2
|
1.327E-1
|
2
|
131
|
8
|
V$E2F1 Q4 01
|
V$E2F1 Q4 01
|
|
6.742E-3
|
2.261E-2
|
9.500E-2
|
2.495E-1
|
2
|
181
|
9
|
V$E2F Q6 01
|
V$E2F Q6 01
|
|
6.961E-3
|
2.261E-2
|
9.500E-2
|
2.576E-1
|
2
|
184
|
10
|
V$E2F Q4 01
|
V$E2F Q4 01
|
|
7.035E-3
|
2.261E-2
|
9.500E-2
|
2.603E-1
|
2
|
185
|
11
|
V$E2F Q3 01
|
V$E2F Q3 01
|
|
7.109E-3
|
2.261E-2
|
9.500E-2
|
2.630E-1
|
2
|
186
|
12
|
V$E2F1 Q6 01
|
V$E2F1 Q6 01
|
|
7.333E-3
|
2.261E-2
|
9.500E-2
|
2.713E-1
|
2
|
189
|
Show 7 more annotations
|
12: Gene Family [Display Chart]
12 input genes in category / 5 annotations before applied cutoff / 18194 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
548
|
Fanconi anemia complementation groups
|
genenames.org
|
4.603E-38
|
2.302E-37
|
5.255E-37
|
2.302E-37
|
12
|
20
|
2
|
1335
|
Fanconi anemia complementation groups|DNA helicases|BRCA1 B complex
|
genenames.org
|
2.636E-3
|
6.590E-3
|
1.505E-2
|
1.318E-2
|
1
|
4
|
3
|
1167
|
INO80 complex |DNA helicases
|
genenames.org
|
1.116E-2
|
1.860E-2
|
4.246E-2
|
5.579E-2
|
1
|
17
|
|
13: Coexpression [Display Chart]
12 input genes in category / 830 annotations before applied cutoff / 23137 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
M12972
|
Genes identified with the Fanconi anemia (FA) and the FA pathway.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.314E-30
|
1.921E-27
|
1.402E-26
|
1.921E-27
|
9
|
11
|
2
|
19695104-AF1-3
|
Human Breast Lin09 10genes
|
GeneSigDB
|
1.215E-19
|
5.040E-17
|
3.679E-16
|
1.008E-16
|
6
|
8
|
3
|
M11563
|
Genes involved in DNA repair, compiled manually by the authors.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.737E-16
|
4.806E-14
|
3.508E-13
|
1.442E-13
|
9
|
230
|
4
|
14993899-TableS1
|
Human Futreal04 427genes ConsensusCancerGenes
|
GeneSigDB
|
1.629E-12
|
3.380E-10
|
2.467E-9
|
1.352E-9
|
8
|
364
|
5
|
M9575
|
DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.484E-11
|
1.076E-8
|
7.856E-8
|
5.381E-8
|
5
|
58
|
6
|
19695104-AF2
|
Human Breast Lin09 128genes
|
GeneSigDB
|
1.586E-10
|
2.194E-8
|
1.601E-7
|
1.316E-7
|
5
|
69
|
7
|
M1819
|
Meitic and DNA repair genes important for female fertility, based on mouse models with female fertility defects.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.378E-9
|
4.005E-7
|
2.923E-6
|
2.804E-6
|
4
|
39
|
8
|
M9150
|
Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.085E-9
|
5.716E-7
|
4.173E-6
|
5.051E-6
|
6
|
323
|
9
|
M2156
|
Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
6.199E-9
|
5.716E-7
|
4.173E-6
|
5.145E-6
|
6
|
324
|
10
|
M2431
|
DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.130E-8
|
1.768E-6
|
1.290E-5
|
1.768E-5
|
4
|
61
|
11
|
M9419
|
Genes up-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
2.540E-6
|
1.917E-4
|
1.399E-3
|
2.108E-3
|
4
|
200
|
12
|
17150101-TableS1h
|
Human Breast Troester06 364genes up DOX-MCF7
|
GeneSigDB
|
9.901E-6
|
6.848E-4
|
4.999E-3
|
8.218E-3
|
4
|
282
|
13
|
M15356
|
Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.726E-5
|
1.102E-3
|
8.044E-3
|
1.433E-2
|
3
|
101
|
14
|
15489886-TableS1b
|
Human Sarcoma Mason04 549genes
|
GeneSigDB
|
6.956E-5
|
3.886E-3
|
2.836E-2
|
5.773E-2
|
4
|
464
|
15
|
M2075
|
Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the S phase of cell cycle.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
7.077E-5
|
3.886E-3
|
2.836E-2
|
5.874E-2
|
3
|
162
|
16
|
19043454-TableS2
|
Human Breast Thorner09 217genes
|
GeneSigDB
|
7.746E-5
|
3.886E-3
|
2.836E-2
|
6.429E-2
|
3
|
167
|
17
|
15548681-Table2
|
Human Breast Wang04 33genes
|
GeneSigDB
|
7.959E-5
|
3.886E-3
|
2.836E-2
|
6.606E-2
|
2
|
26
|
18
|
M2848
|
Genes down-regulated in MOLM-14 cells (AML) with knockdown of HOXA9 [Gene ID=3205] gene by RNAi vs controls.
|
MSigDB C6: Oncogenic Signatures (v6.0)
|
1.189E-4
|
4.638E-3
|
3.386E-2
|
9.872E-2
|
3
|
193
|
19
|
18338247-SuppTable4A
|
Human Breast Harvell08 308genes
|
GeneSigDB
|
1.245E-4
|
4.638E-3
|
3.386E-2
|
1.033E-1
|
3
|
196
|
20
|
M7185
|
Genes up-regulated in transitional CR2 [GeneID=1380] high B lymphocytes versus those from cord blood.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.322E-4
|
4.638E-3
|
3.386E-2
|
1.097E-1
|
3
|
200
|
21
|
M5303
|
Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 72 h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.322E-4
|
4.638E-3
|
3.386E-2
|
1.097E-1
|
3
|
200
|
22
|
M8109
|
Genes down-regulated in IL10 [GeneID=3586] knockout macrophages: unstimulated versus stimulated by IL10 [GeneID=3586] and LPS.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.322E-4
|
4.638E-3
|
3.386E-2
|
1.097E-1
|
3
|
200
|
23
|
M5292
|
Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 40 h.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
1.322E-4
|
4.638E-3
|
3.386E-2
|
1.097E-1
|
3
|
200
|
24
|
M14340
|
Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.341E-4
|
4.638E-3
|
3.386E-2
|
1.113E-1
|
3
|
201
|
25
|
20035825-TableS8b
|
Human Lung Mikkonen10 59genes
|
GeneSigDB
|
1.999E-4
|
6.638E-3
|
4.845E-2
|
1.660E-1
|
2
|
41
|
26
|
16886892-Table2
|
Human Breast Chalabi06 57genes
|
GeneSigDB
|
2.520E-4
|
7.752E-3
|
5.658E-2
|
2.092E-1
|
2
|
46
|
27
|
M11318
|
Genes down-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.522E-4
|
7.752E-3
|
5.658E-2
|
2.093E-1
|
3
|
249
|
28
|
16912175-SuppTable3a
|
Human HeadandNeck Sengupta06 403genes
|
GeneSigDB
|
3.864E-4
|
1.145E-2
|
8.360E-2
|
3.207E-1
|
3
|
288
|
29
|
M15969
|
Cluster 1: genes up-regulated by RB1, CDNK2A [GeneID=1029;5925], and one of the E2Fs (E2F1, E2F2, or E2F3 [GeneID=1869;1870;1871]).
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
5.840E-4
|
1.671E-2
|
1.220E-1
|
4.847E-1
|
2
|
70
|
30
|
19139136-TableS2
|
Human Prostate John-Aryankalayil09 450genes
|
GeneSigDB
|
6.217E-4
|
1.720E-2
|
1.256E-1
|
5.161E-1
|
3
|
339
|
31
|
18662380-S3-AURKA
|
Human Breast Wirapati08 355genes AURKA Module
|
GeneSigDB
|
6.488E-4
|
1.737E-2
|
1.268E-1
|
5.385E-1
|
3
|
344
|
32
|
M1916
|
Genes down-regulated in neural stem cells (NSC) at both 36 h and 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
9.417E-4
|
2.443E-2
|
1.783E-1
|
7.816E-1
|
2
|
89
|
33
|
M9516
|
Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.181E-3
|
2.969E-2
|
2.167E-1
|
9.799E-1
|
3
|
423
|
34
|
M18855
|
Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.221E-3
|
2.981E-2
|
2.176E-1
|
1.000E0
|
3
|
428
|
35
|
17150101-TableS1c
|
Human Breast Troester06 134genes up DoxTreated-HME-CC
|
GeneSigDB
|
1.357E-3
|
3.217E-2
|
2.348E-1
|
1.000E0
|
2
|
107
|
36
|
M8520
|
Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
1.466E-3
|
3.379E-2
|
2.466E-1
|
1.000E0
|
3
|
456
|
37
|
M2802
|
Genes up-regulated in primary keratinocytes from RB1 and RBL1 [Gene ID=5925, 5933] skin specific knockout mice.
|
MSigDB C6: Oncogenic Signatures (v6.0)
|
2.274E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
139
|
38
|
M6085
|
Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (2h) versus IL4 [GeneID=3565] (2h).
|
MSigDB C7: Immunologic Signatures (v6.0)
|
2.274E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
139
|
39
|
M3045
|
Genes up-regulated in CD4+ [GeneID=920] T lymphocytes after stimulation with prostaglandin E2 [PubChem=5280360].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.504E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
146
|
40
|
M2114
|
Set 'Proliferation Cluster': genes defined in human breast tumor expression data.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
2.538E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
147
|
41
|
M438
|
Genes up-regulated in CAL1 cells (plasmacytoid dendritic cells) versus MOLT4 (immature T cells).
|
MSigDB C7: Immunologic Signatures (v6.0)
|
2.675E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
151
|
42
|
M8235
|
Genes up-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype versus RORC [GeneID=6097] knockout.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
3.034E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
161
|
43
|
M19957
|
Genes up-regulated in genomically unstable Ewing's sarcoma tumors compared to the stable ones.
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.259E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
167
|
44
|
20068086-ST1-5
|
Human Breast Lee10 184genes
|
GeneSigDB
|
3.375E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
170
|
45
|
M17193
|
Down-regulated genes distinguishing in multiple myeloma (MM) samples with lower expression of TACI [GeneID=23495].
|
MSigDB C2: CGP Curated Gene Sets (v6.0)
|
3.453E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
172
|
46
|
M6694
|
Genes down-regulated in endothelial cells: untreated versus interferon beta.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
3.492E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
173
|
47
|
M8990
|
Genes up-regulated in CD4 [GeneID=920] T cells treated with rosiglitazone [PubChem=77999] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 isoform of PPARG [GeneID=5468].
|
MSigDB C7: Immunologic Signatures (v6.0)
|
3.532E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
174
|
48
|
20035825-TableS7b
|
Human Lung Mikkonen10 209genes
|
GeneSigDB
|
3.572E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
175
|
49
|
18498629-GeneList
|
Human Breast Loi08 239genes
|
GeneSigDB
|
3.692E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
178
|
50
|
M6857
|
Genes up-regulated in spleens from mice immunized with ova peptides alone versus those immunized with monophosphoryl lipid A as adjuvant.
|
MSigDB C7: Immunologic Signatures (v6.0)
|
3.774E-3
|
3.581E-2
|
2.614E-1
|
1.000E0
|
2
|
180
|
Show 45 more annotations
|
14: Coexpression Atlas [Display Chart]
12 input genes in category / 302 annotations before applied cutoff / 21829 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
gudmap dev gonad e13.5 F MeioticGermCell Oct k2 500
|
dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
1.167E-8
|
3.524E-6
|
2.216E-5
|
3.524E-6
|
5
|
152
|
2
|
gudmap dev gonad e12.5 M GermCellTestis Oct k2 1000
|
dev gonad e12.5 M GermCellTestis Oct k-means-cluster#2 top-relative-expression-ranked 1000
|
Gudmap Mouse ST 1.0
|
1.911E-7
|
2.445E-5
|
1.538E-4
|
5.772E-5
|
5
|
266
|
3
|
gudmap dev gonad e12.5 M GermCellTestis Oct k1 500
|
dev gonad e12.5 M GermCellTestis Oct k-means-cluster#1 top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
2.429E-7
|
2.445E-5
|
1.538E-4
|
7.335E-5
|
4
|
105
|
4
|
gudmap dev gonad e12.5 F GermCellOvary Oct k3 500
|
dev gonad e12.5 F GermCellOvary Oct k-means-cluster#3 top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
3.381E-7
|
2.553E-5
|
1.606E-4
|
1.021E-4
|
4
|
114
|
5
|
gudmap dev gonad e13.5 F MeioticGermCell Oct k2 1000
|
dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000
|
Gudmap Mouse ST 1.0
|
8.663E-7
|
5.232E-5
|
3.291E-4
|
2.616E-4
|
5
|
361
|
6
|
gudmap dev gonad e13.5 F MeioticGermCell Oct 500
|
dev gonad e13.5 F MeioticGermCell Oct top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
1.189E-6
|
5.987E-5
|
3.765E-4
|
3.592E-4
|
5
|
385
|
7
|
gudmap dev gonad e12.5 F GermCellOvary Oct 500
|
dev gonad e12.5 F GermCellOvary Oct top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
1.545E-6
|
6.664E-5
|
4.191E-4
|
4.664E-4
|
5
|
406
|
8
|
Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Papillary Muscle Invasive Urothelial Carcinoma/2/4
|
Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Papillary Muscle Invasive Urothelial Carcinoma/2/4
|
TCGA-Bladder
|
2.395E-6
|
9.041E-5
|
5.686E-4
|
7.233E-4
|
4
|
186
|
9
|
gudmap dev gonad e11.5 M PrimGermCell Oct k2 1000
|
dev gonad e11.5 M PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000
|
Gudmap Mouse ST 1.0
|
8.759E-6
|
2.939E-4
|
1.849E-3
|
2.645E-3
|
4
|
258
|
10
|
gudmap dev gonad e11.5 F PrimGermCell Oct k2 1000
|
dev gonad e11.5 F PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000
|
Gudmap Mouse ST 1.0
|
2.240E-5
|
6.640E-4
|
4.176E-3
|
6.765E-3
|
3
|
104
|
11
|
gudmap dev gonad e13.5 M GermCell Oct k1 1000
|
dev gonad e13.5 M GermCell Oct k-means-cluster#1 top-relative-expression-ranked 1000
|
Gudmap Mouse ST 1.0
|
2.418E-5
|
6.640E-4
|
4.176E-3
|
7.304E-3
|
4
|
334
|
12
|
gudmap dev gonad e11.5 F PrimGermCell Oct 500
|
dev gonad e11.5 F PrimGermCell Oct top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
4.259E-5
|
9.994E-4
|
6.285E-3
|
1.286E-2
|
4
|
386
|
13
|
gudmap dev gonad e12.5 M GermCellTestis Oct 500
|
dev gonad e12.5 M GermCellTestis Oct top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
4.302E-5
|
9.994E-4
|
6.285E-3
|
1.299E-2
|
4
|
387
|
14
|
GSM399452 500
|
B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3
|
Immgen.org, GSE15907
|
5.336E-5
|
1.085E-3
|
6.822E-3
|
1.612E-2
|
4
|
409
|
15
|
GSM538387 500
|
alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3
|
Immgen.org, GSE15907
|
5.387E-5
|
1.085E-3
|
6.822E-3
|
1.627E-2
|
4
|
410
|
16
|
GSM399403 500
|
alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3
|
Immgen.org, GSE15907
|
5.754E-5
|
1.086E-3
|
6.831E-3
|
1.738E-2
|
4
|
417
|
17
|
gudmap kidney e15.5 SmlBldVes Tie2 k3 1000
|
kidney e15.5 SmlBldVes Tie2 k-means-cluster#3 top-relative-expression-ranked 1000
|
Gudmap Mouse MOE430.2
|
2.398E-4
|
4.260E-3
|
2.679E-2
|
7.242E-2
|
3
|
231
|
18
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes
|
|
6.224E-4
|
9.398E-3
|
5.911E-2
|
1.880E-1
|
3
|
320
|
19
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200
|
Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200
|
|
6.224E-4
|
9.398E-3
|
5.911E-2
|
1.880E-1
|
3
|
320
|
20
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes
|
BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes
|
BrainMap
|
6.224E-4
|
9.398E-3
|
5.911E-2
|
1.880E-1
|
3
|
320
|
21
|
gudmap dev gonad e11.5 F PrimGermCell Oct k3 500
|
dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 500
|
Gudmap Mouse ST 1.0
|
6.931E-4
|
9.968E-3
|
6.269E-2
|
2.093E-1
|
2
|
72
|
22
|
GSM538207 500
|
B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3
|
Immgen.org, GSE15907
|
1.024E-3
|
1.406E-2
|
8.845E-2
|
3.094E-1
|
3
|
380
|
23
|
GSM791143 500
|
alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.162E-3
|
1.456E-2
|
9.156E-2
|
3.511E-1
|
3
|
397
|
24
|
GSM399397 500
|
alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3
|
Immgen.org, GSE15907
|
1.179E-3
|
1.456E-2
|
9.156E-2
|
3.562E-1
|
3
|
399
|
25
|
GSM605898 500
|
alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3
|
Immgen.org, GSE15907
|
1.205E-3
|
1.456E-2
|
9.156E-2
|
3.640E-1
|
3
|
402
|
26
|
GSM476664 500
|
gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3
|
Immgen.org, GSE15907
|
1.358E-3
|
1.495E-2
|
9.402E-2
|
4.101E-1
|
3
|
419
|
27
|
GSM791141 500
|
alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2
|
Immgen.org, GSE15907
|
1.367E-3
|
1.495E-2
|
9.402E-2
|
4.129E-1
|
3
|
420
|
28
|
GSM538357 500
|
B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1
|
Immgen.org, GSE15907
|
1.386E-3
|
1.495E-2
|
9.402E-2
|
4.186E-1
|
3
|
422
|
29
|
Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/late fetal/CM f
|
Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/late fetal/CM f
|
Fetal, Development
|
1.908E-3
|
1.987E-2
|
1.250E-1
|
5.762E-1
|
2
|
120
|
30
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/Thalamus
|
BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/Thalamus
|
BrainMap
|
2.167E-3
|
2.181E-2
|
1.372E-1
|
6.543E-1
|
2
|
128
|
31
|
Facebase RNAseq e10.5 Lateral Nasal Eminence 500 K3
|
FacebaseRNAseq e10.5 Lateral Nasal Eminence top-relative-expression-ranked 500 k-means-cluster#3
|
FaceBase_RNAseq
|
2.406E-3
|
2.344E-2
|
1.474E-1
|
7.266E-1
|
2
|
135
|
32
|
Cap mesenchyme (CM)/Cap mesenchyme (CM) f
|
Cap mesenchyme (CM)/Cap mesenchyme (CM) f
|
|
5.089E-3
|
4.803E-2
|
3.021E-1
|
1.000E0
|
2
|
198
|
Show 27 more annotations
|
15: Computational [Display Chart]
9 input genes in category / 83 annotations before applied cutoff / 10037 genes in category
|
16: MicroRNA [Display Chart]
12 input genes in category / 316 annotations before applied cutoff / 72241 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
hsa-miR-4268:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
7.738E-5
|
2.445E-2
|
1.549E-1
|
2.445E-2
|
2
|
79
|
2
|
hsa-miR-1273:mirSVR highEffct
|
hsa-miR-1273:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
4.748E-4
|
3.877E-2
|
2.456E-1
|
1.500E-1
|
2
|
196
|
3
|
hsa-miR-6783-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.135E-4
|
3.877E-2
|
2.456E-1
|
1.939E-1
|
2
|
223
|
4
|
hsa-miR-1343-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
6.135E-4
|
3.877E-2
|
2.456E-1
|
1.939E-1
|
2
|
223
|
5
|
hsa-miR-505-3p:Functional MTI
|
Functional MTI
|
miRTarbase
|
6.135E-4
|
3.877E-2
|
2.456E-1
|
1.939E-1
|
2
|
223
|
6
|
hsa-miR-4755-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.068E-3
|
4.303E-2
|
2.726E-1
|
3.374E-1
|
2
|
295
|
7
|
hsa-miR-4664-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.328E-3
|
4.303E-2
|
2.726E-1
|
4.197E-1
|
1
|
8
|
8
|
hsa-miR-1247-3p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
1.454E-3
|
4.303E-2
|
2.726E-1
|
4.595E-1
|
2
|
345
|
9
|
hsa-miR-30e-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.471E-3
|
4.303E-2
|
2.726E-1
|
4.648E-1
|
2
|
347
|
10
|
hsa-miR-886-5p:mirSVR lowEffct
|
hsa-miR-886-5p:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
1.590E-3
|
4.303E-2
|
2.726E-1
|
5.025E-1
|
2
|
361
|
11
|
hsa-miR-30d-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
1.651E-3
|
4.303E-2
|
2.726E-1
|
5.218E-1
|
2
|
368
|
12
|
hsa-miR-3194:mirSVR highEffct
|
hsa-miR-3194:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
1.741E-3
|
4.303E-2
|
2.726E-1
|
5.501E-1
|
2
|
378
|
13
|
hsa-miR-4286:mirSVR highEffct
|
hsa-miR-4286:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
1.870E-3
|
4.303E-2
|
2.726E-1
|
5.909E-1
|
2
|
392
|
14
|
hsa-miR-553:mirSVR highEffct
|
hsa-miR-553:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
1.955E-3
|
4.303E-2
|
2.726E-1
|
6.179E-1
|
2
|
401
|
15
|
hsa-miR-30b-5p:Functional MTI
|
Functional MTI
|
miRTarbase
|
2.102E-3
|
4.303E-2
|
2.726E-1
|
6.641E-1
|
2
|
416
|
16
|
hsa-miR-744-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
2.304E-3
|
4.303E-2
|
2.726E-1
|
7.282E-1
|
2
|
436
|
17
|
hsa-miR-611:mirSVR lowEffct
|
hsa-miR-611:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.315E-3
|
4.303E-2
|
2.726E-1
|
7.315E-1
|
2
|
437
|
18
|
hsa-miR-542-5p:mirSVR lowEffct
|
hsa-miR-542-5p:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.604E-3
|
4.342E-2
|
2.750E-1
|
8.227E-1
|
2
|
464
|
19
|
hsa-miR-4284:mirSVR highEffct
|
hsa-miR-4284:mirSVR nonconserved highEffect-0.5
|
MicroRNA.org
|
2.748E-3
|
4.342E-2
|
2.750E-1
|
8.685E-1
|
2
|
477
|
20
|
hsa-miR-3141:mirSVR lowEffct
|
hsa-miR-3141:mirSVR nonconserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.794E-3
|
4.342E-2
|
2.750E-1
|
8.828E-1
|
2
|
481
|
21
|
hsa-miR-210:mirSVR lowEffct
|
hsa-miR-210:mirSVR conserved lowEffect-0.1-0.5
|
MicroRNA.org
|
2.885E-3
|
4.342E-2
|
2.750E-1
|
9.118E-1
|
2
|
489
|
22
|
CGCTGCT,MIR-503:MSigDB
|
CGCTGCT,MIR-503:MSigDB
|
MSigDB
|
3.152E-3
|
4.527E-2
|
2.868E-1
|
9.960E-1
|
1
|
19
|
23
|
hsa-miR-6840-5p:Functional MTI (Weak)
|
Functional MTI (Weak)
|
miRTarbase
|
3.317E-3
|
4.558E-2
|
2.887E-1
|
1.000E0
|
1
|
20
|
Show 18 more annotations
|
17: Drug [Display Chart]
12 input genes in category / 2177 annotations before applied cutoff / 22841 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
CID000004638
|
AC1L1IM7
|
Stitch
|
7.246E-30
|
1.577E-26
|
1.303E-25
|
1.577E-26
|
11
|
46
|
2
|
CID000004915
|
procarbazine
|
Stitch
|
3.305E-26
|
3.597E-23
|
2.973E-22
|
7.195E-23
|
11
|
93
|
3
|
CID000121904
|
6-deoxyerythronolide B
|
Stitch
|
5.391E-26
|
3.912E-23
|
3.233E-22
|
1.174E-22
|
11
|
97
|
4
|
CID000011254
|
diepoxybutane
|
Stitch
|
3.149E-25
|
1.678E-22
|
1.387E-21
|
6.856E-22
|
11
|
113
|
5
|
CID004629339
|
AC1NDP1U
|
Stitch
|
3.854E-25
|
1.678E-22
|
1.387E-21
|
8.390E-22
|
11
|
115
|
6
|
CID000002249
|
atenolol
|
Stitch
|
7.598E-25
|
2.757E-22
|
2.278E-21
|
1.654E-21
|
11
|
122
|
7
|
CID000005746
|
mitomycin C
|
Stitch
|
1.706E-21
|
5.305E-19
|
4.384E-18
|
3.714E-18
|
11
|
241
|
8
|
CID004631220
|
AC1NDT8D
|
Stitch
|
4.878E-21
|
1.327E-18
|
1.097E-17
|
1.062E-17
|
8
|
34
|
9
|
CID000025440
|
Demetric acid
|
Stitch
|
2.064E-20
|
4.993E-18
|
4.126E-17
|
4.493E-17
|
8
|
40
|
10
|
CID011968289
|
[(2S)-2-[(Z)-dodec-9-enoyl]oxy-3-tetradecanoyloxypropyl] [(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl] phosphate
|
Stitch
|
6.846E-19
|
1.490E-16
|
1.231E-15
|
1.490E-15
|
8
|
60
|
11
|
ctd:C471109
|
4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline
|
CTD
|
2.497E-18
|
4.941E-16
|
4.083E-15
|
5.435E-15
|
7
|
30
|
12
|
CID000006235
|
Trenimon
|
Stitch
|
1.268E-16
|
2.301E-14
|
1.901E-13
|
2.761E-13
|
6
|
19
|
13
|
ctd:C408982
|
CPG-oligonucleotide
|
CTD
|
7.328E-15
|
1.227E-12
|
1.014E-11
|
1.595E-11
|
8
|
184
|
14
|
CID000004114
|
8-MOP
|
Stitch
|
6.358E-14
|
9.886E-12
|
8.169E-11
|
1.384E-10
|
7
|
118
|
15
|
CID000175468
|
12-bromolaurate
|
Stitch
|
1.682E-13
|
2.441E-11
|
2.017E-10
|
3.661E-10
|
6
|
57
|
16
|
CID000001292
|
PPCM
|
Stitch
|
2.087E-13
|
2.840E-11
|
2.347E-10
|
4.544E-10
|
6
|
59
|
17
|
CID000002907
|
cyclophosphamide
|
Stitch
|
7.632E-13
|
9.773E-11
|
8.076E-10
|
1.661E-9
|
8
|
327
|
18
|
CID000001642
|
AC1L1BWR
|
Stitch
|
1.009E-12
|
1.220E-10
|
1.008E-9
|
2.196E-9
|
6
|
76
|
19
|
CID000002973
|
deferoxamine
|
Stitch
|
1.120E-12
|
1.283E-10
|
1.060E-9
|
2.438E-9
|
8
|
343
|
20
|
CID000008420
|
2-naphthalenesulfonate
|
Stitch
|
3.279E-12
|
3.569E-10
|
2.949E-9
|
7.138E-9
|
6
|
92
|
21
|
CID006433481
|
hygromycin A
|
Stitch
|
5.815E-12
|
6.029E-10
|
4.982E-9
|
1.266E-8
|
6
|
101
|
22
|
CID005493470
|
NM-3
|
Stitch
|
4.777E-11
|
4.727E-9
|
3.906E-8
|
1.040E-7
|
5
|
54
|
23
|
CID000001800
|
5-amidinobenzimidazole
|
Stitch
|
7.611E-11
|
7.204E-9
|
5.953E-8
|
1.657E-7
|
6
|
154
|
24
|
CID005323583
|
rufochromomycin
|
Stitch
|
2.549E-9
|
2.312E-7
|
1.910E-6
|
5.549E-6
|
4
|
36
|
25
|
CID000446186
|
1i32
|
Stitch
|
4.078E-9
|
3.551E-7
|
2.934E-6
|
8.878E-6
|
5
|
129
|
26
|
CID000446057
|
1hef
|
Stitch
|
4.376E-9
|
3.664E-7
|
3.027E-6
|
9.526E-6
|
4
|
41
|
27
|
CID000070065
|
Pb-D
|
Stitch
|
6.855E-9
|
5.527E-7
|
4.567E-6
|
1.492E-5
|
5
|
143
|
28
|
CID000167827
|
fusigen
|
Stitch
|
1.327E-8
|
1.006E-6
|
8.311E-6
|
2.888E-5
|
3
|
10
|
29
|
CID000004156
|
methyl methanesulfonate
|
Stitch
|
1.340E-8
|
1.006E-6
|
8.311E-6
|
2.917E-5
|
6
|
364
|
30
|
CID000064960
|
1,5-AG
|
Stitch
|
2.301E-8
|
1.661E-6
|
1.372E-5
|
5.010E-5
|
5
|
182
|
31
|
CID000023939
|
platinum
|
Stitch
|
2.365E-8
|
1.661E-6
|
1.372E-5
|
5.149E-5
|
5
|
183
|
32
|
CID000134350
|
PADP
|
Stitch
|
7.502E-8
|
5.104E-6
|
4.217E-5
|
1.633E-4
|
3
|
17
|
33
|
CID000001174
|
uracil
|
Stitch
|
1.616E-7
|
1.066E-5
|
8.809E-5
|
3.518E-4
|
5
|
269
|
34
|
CID000656926
|
AC1LCVPZ
|
Stitch
|
2.447E-7
|
1.567E-5
|
1.294E-4
|
5.326E-4
|
4
|
110
|
35
|
CID000019390
|
AC1L2E0P
|
Stitch
|
3.113E-7
|
1.936E-5
|
1.600E-4
|
6.777E-4
|
5
|
307
|
36
|
CID005460240
|
tungstopterin
|
Stitch
|
4.936E-7
|
2.985E-5
|
2.467E-4
|
1.075E-3
|
4
|
131
|
37
|
CID000065577
|
Topo
|
Stitch
|
9.189E-7
|
5.407E-5
|
4.468E-4
|
2.001E-3
|
4
|
153
|
38
|
CID000063306
|
NU1025
|
Stitch
|
1.257E-6
|
7.203E-5
|
5.952E-4
|
2.737E-3
|
3
|
42
|
39
|
CID000001478
|
AC1L1BKI
|
Stitch
|
1.660E-6
|
9.269E-5
|
7.659E-4
|
3.615E-3
|
3
|
46
|
40
|
CID000005192
|
sebacate
|
Stitch
|
1.797E-6
|
9.779E-5
|
8.080E-4
|
3.912E-3
|
4
|
181
|
41
|
3283 DN
|
Digoxin [20830-75-5]; Down 200; 5.2uM; MCF7; HT HG-U133A
|
Broad Institute CMAP Down
|
2.046E-6
|
1.086E-4
|
8.976E-4
|
4.454E-3
|
4
|
187
|
42
|
CID000004199
|
minaprine
|
Stitch
|
2.707E-6
|
1.403E-4
|
1.159E-3
|
5.893E-3
|
3
|
54
|
43
|
CID000409844
|
5H-purin-2-amine
|
Stitch
|
1.847E-5
|
9.352E-4
|
7.728E-3
|
4.022E-2
|
3
|
102
|
44
|
ctd:D010042
|
Ouabain
|
CTD
|
3.005E-5
|
1.463E-3
|
1.209E-2
|
6.543E-2
|
3
|
120
|
45
|
CID000000671
|
d Na
|
Stitch
|
3.024E-5
|
1.463E-3
|
1.209E-2
|
6.583E-2
|
2
|
16
|
46
|
CID000000955
|
o-succinylbenzoic acid
|
Stitch
|
3.853E-5
|
1.824E-3
|
1.507E-2
|
8.388E-2
|
2
|
18
|
47
|
ctd:D016685
|
Mitomycin
|
CTD
|
4.518E-5
|
2.093E-3
|
1.729E-2
|
9.836E-2
|
4
|
410
|
48
|
CID000003657
|
hydroxyurea
|
Stitch
|
5.844E-5
|
2.650E-3
|
2.190E-2
|
1.272E-1
|
4
|
438
|
49
|
CID005289542
|
UV-C
|
Stitch
|
7.487E-5
|
3.326E-3
|
2.749E-2
|
1.630E-1
|
3
|
163
|
50
|
ctd:C007366
|
erythritol anhydride
|
CTD
|
8.166E-5
|
3.486E-3
|
2.880E-2
|
1.778E-1
|
2
|
26
|
Show 45 more annotations
|
18: Disease [Display Chart]
12 input genes in category / 296 annotations before applied cutoff / 16205 genes in category
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
cv:C1861028
|
Tracheoesophageal fistula
|
Clinical Variations
|
4.311E-37
|
1.276E-34
|
8.000E-34
|
1.276E-34
|
12
|
21
|
2
|
C0272027
|
Pyridoxine-responsive sideroblastic anemia
|
DisGeNET Curated
|
2.521E-26
|
3.731E-24
|
2.339E-23
|
7.461E-24
|
9
|
17
|
3
|
C4024780
|
Almond-shaped eyes
|
DisGeNET Curated
|
3.235E-24
|
3.192E-22
|
2.001E-21
|
9.575E-22
|
9
|
26
|
4
|
C1859424
|
Increased chromosomal breakage
|
DisGeNET Curated
|
4.852E-24
|
3.590E-22
|
2.251E-21
|
1.436E-21
|
9
|
27
|
5
|
C0014850
|
Esophageal Atresia
|
DisGeNET Curated
|
1.036E-23
|
5.113E-22
|
3.205E-21
|
3.068E-21
|
9
|
29
|
6
|
C2749463
|
Radial aplasia/hypoplasia
|
DisGeNET Curated
|
1.036E-23
|
5.113E-22
|
3.205E-21
|
3.068E-21
|
9
|
29
|
7
|
C0376628
|
Chromosome Breakage
|
DisGeNET Curated
|
2.901E-23
|
1.227E-21
|
7.691E-21
|
8.587E-21
|
9
|
32
|
8
|
C1860236
|
Irregular hyperpigmentation
|
DisGeNET Curated
|
3.988E-23
|
1.476E-21
|
9.251E-21
|
1.181E-20
|
9
|
33
|
9
|
OMIN:227650
|
FANCONI ANEMIA; FA
|
OMIM
|
1.089E-22
|
3.583E-21
|
2.246E-20
|
3.224E-20
|
7
|
8
|
10
|
C0040588
|
Tracheoesophageal Fistula
|
DisGeNET Curated
|
1.286E-22
|
3.805E-21
|
2.386E-20
|
3.805E-20
|
9
|
37
|
11
|
C3469521
|
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
DisGeNET Curated
|
1.539E-22
|
4.142E-21
|
2.596E-20
|
4.556E-20
|
12
|
252
|
12
|
C0423112
|
Short palpebral fissure
|
DisGeNET Curated
|
1.684E-22
|
4.155E-21
|
2.605E-20
|
4.986E-20
|
9
|
38
|
13
|
C0015625
|
Fanconi Anemia
|
DisGeNET Curated
|
6.953E-22
|
1.583E-20
|
9.925E-20
|
2.058E-19
|
12
|
285
|
14
|
C1836735
|
hypopigmented skin patch
|
DisGeNET Curated
|
1.522E-20
|
3.218E-19
|
2.017E-18
|
4.505E-18
|
9
|
60
|
15
|
C0392386
|
Decreased platelet count
|
DisGeNET Curated
|
5.607E-18
|
1.107E-16
|
6.937E-16
|
1.660E-15
|
9
|
112
|
16
|
C0023530
|
Leukopenia
|
DisGeNET Curated
|
5.360E-15
|
9.916E-14
|
6.217E-13
|
1.587E-12
|
9
|
236
|
17
|
C0037932
|
Curvature of spine
|
DisGeNET Curated
|
3.178E-14
|
5.534E-13
|
3.469E-12
|
9.407E-12
|
9
|
287
|
18
|
C0040034
|
Thrombocytopenia
|
DisGeNET Curated
|
4.751E-14
|
7.813E-13
|
4.898E-12
|
1.406E-11
|
9
|
300
|
19
|
C0700208
|
Acquired scoliosis
|
DisGeNET Curated
|
5.357E-14
|
8.346E-13
|
5.233E-12
|
1.586E-11
|
9
|
304
|
20
|
C4025639
|
Prolonged G2 phase of cell cycle
|
DisGeNET Curated
|
1.723E-13
|
2.319E-12
|
1.454E-11
|
5.101E-11
|
4
|
4
|
21
|
C4025640
|
Deficient excision of UV-induced pyrimidine dimers in DNA
|
DisGeNET Curated
|
1.723E-13
|
2.319E-12
|
1.454E-11
|
5.101E-11
|
4
|
4
|
22
|
C4025811
|
Anemic pallor
|
DisGeNET Curated
|
1.723E-13
|
2.319E-12
|
1.454E-11
|
5.101E-11
|
4
|
4
|
23
|
C1849314
|
Absence of radius and ulna
|
DisGeNET Curated
|
2.546E-13
|
3.277E-12
|
2.054E-11
|
7.537E-11
|
5
|
15
|
24
|
C0424688
|
Small head
|
DisGeNET Curated
|
3.581E-13
|
4.059E-12
|
2.545E-11
|
1.060E-10
|
9
|
375
|
25
|
C3278811
|
Thumb aplasia
|
DisGeNET Curated
|
3.702E-13
|
4.059E-12
|
2.545E-11
|
1.096E-10
|
5
|
16
|
26
|
C1405984
|
Absent radius
|
DisGeNET Curated
|
3.702E-13
|
4.059E-12
|
2.545E-11
|
1.096E-10
|
5
|
16
|
27
|
C1838608
|
Radial aplasia
|
DisGeNET Curated
|
3.702E-13
|
4.059E-12
|
2.545E-11
|
1.096E-10
|
5
|
16
|
28
|
C4021737
|
Chromosomal breakage induced by crosslinking agents
|
DisGeNET Curated
|
8.613E-13
|
9.106E-12
|
5.709E-11
|
2.550E-10
|
4
|
5
|
29
|
C0162119
|
Hemoglobin low
|
DisGeNET Curated
|
1.178E-12
|
1.202E-11
|
7.539E-11
|
3.487E-10
|
7
|
127
|
30
|
C3554724
|
Digitalization of thumbs
|
DisGeNET Curated
|
2.583E-12
|
2.549E-11
|
1.598E-10
|
7.646E-10
|
4
|
6
|
31
|
C1858565
|
Duplicated collecting system
|
DisGeNET Curated
|
6.025E-12
|
5.753E-11
|
3.606E-10
|
1.783E-9
|
4
|
7
|
32
|
C0265974
|
Birthmark
|
DisGeNET Curated
|
2.733E-11
|
2.528E-10
|
1.585E-9
|
8.089E-9
|
5
|
35
|
33
|
C0858867
|
Reticulocytopenia
|
DisGeNET Curated
|
3.611E-11
|
3.192E-10
|
2.001E-9
|
1.069E-8
|
4
|
10
|
34
|
C0221263
|
Cafe-au-Lait Spots
|
DisGeNET Curated
|
3.667E-11
|
3.192E-10
|
2.001E-9
|
1.085E-8
|
5
|
37
|
35
|
C0542519
|
Congenital absence of kidney
|
DisGeNET Curated
|
7.143E-11
|
6.041E-10
|
3.787E-9
|
2.114E-8
|
5
|
42
|
36
|
C0238207
|
Ectopic kidney
|
DisGeNET Curated
|
8.504E-11
|
6.992E-10
|
4.383E-9
|
2.517E-8
|
4
|
12
|
37
|
C0002871
|
Anemia
|
DisGeNET Curated
|
1.204E-10
|
9.631E-10
|
6.038E-9
|
3.563E-8
|
8
|
438
|
38
|
C0853697
|
Neutrophil count decreased
|
DisGeNET Curated
|
1.435E-10
|
1.118E-9
|
7.007E-9
|
4.247E-8
|
5
|
48
|
39
|
C0221353
|
Horseshoe Kidney
|
DisGeNET Curated
|
3.122E-10
|
2.369E-9
|
1.485E-8
|
9.240E-8
|
4
|
16
|
40
|
C1260926
|
Abnormal pigmentation
|
DisGeNET Curated
|
2.162E-9
|
1.600E-8
|
1.003E-7
|
6.400E-7
|
4
|
25
|
41
|
C0431890
|
Hypoplasia of thumb
|
DisGeNET Curated
|
2.997E-9
|
2.164E-8
|
1.357E-7
|
8.872E-7
|
4
|
27
|
42
|
C0030312
|
Pancytopenia
|
DisGeNET Curated
|
8.315E-9
|
5.860E-8
|
3.674E-7
|
2.461E-6
|
5
|
106
|
43
|
C0346153
|
Breast Cancer, Familial
|
DisGeNET Curated
|
3.893E-8
|
2.622E-7
|
1.644E-6
|
1.152E-5
|
5
|
144
|
44
|
C0948896
|
Primary hypogonadism
|
DisGeNET Curated
|
3.897E-8
|
2.622E-7
|
1.644E-6
|
1.154E-5
|
4
|
50
|
45
|
C3160738
|
FANCONI ANEMIA, COMPLEMENTATION GROUP D2
|
DisGeNET Curated
|
8.836E-8
|
5.812E-7
|
3.644E-6
|
2.616E-5
|
3
|
13
|
46
|
C0423798
|
Increased tendency to bruise
|
DisGeNET Curated
|
1.288E-7
|
8.114E-7
|
5.087E-6
|
3.814E-5
|
4
|
67
|
47
|
C0013491
|
Ecchymosis
|
DisGeNET Curated
|
1.288E-7
|
8.114E-7
|
5.087E-6
|
3.814E-5
|
4
|
67
|
48
|
C0235991
|
Small for gestational age (disorder)
|
DisGeNET Curated
|
1.452E-7
|
8.772E-7
|
5.499E-6
|
4.298E-5
|
4
|
69
|
49
|
C0024032
|
Low Birth Weights
|
DisGeNET Curated
|
1.452E-7
|
8.772E-7
|
5.499E-6
|
4.298E-5
|
4
|
69
|
50
|
C0005859
|
Bloom Syndrome
|
DisGeNET Curated
|
3.543E-7
|
2.097E-6
|
1.315E-5
|
1.049E-4
|
4
|
86
|
Show 45 more annotations
|
|