Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc350_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 20 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008528 G protein-coupled peptide receptor activity 3.424E-6 3.664E-5 1.318E-4 6.848E-5 3 132
2 GO:0001653 peptide receptor activity 3.664E-6 3.664E-5 1.318E-4 7.328E-5 3 135
3 GO:0042923 neuropeptide binding 1.450E-5 9.666E-5 3.477E-4 2.900E-4 2 23
4 GO:0008188 neuropeptide receptor activity 5.917E-5 2.958E-4 1.064E-3 1.183E-3 2 46
5 GO:0001604 urotensin II receptor activity 2.679E-4 1.072E-3 3.856E-3 5.359E-3 1 1
6 GO:0004946 bombesin receptor activity 8.036E-4 2.679E-3 9.638E-3 1.607E-2 1 3
7 GO:0004994 somatostatin receptor activity 1.339E-3 3.826E-3 1.377E-2 2.678E-2 1 5
8 GO:0042277 peptide binding 2.147E-3 5.367E-3 1.931E-2 4.294E-2 2 278
9 GO:0033218 amide binding 2.644E-3 5.876E-3 2.114E-2
5.289E-2
 2 309
10 GO:0017075 syntaxin-1 binding 5.348E-3 1.070E-2 3.848E-2
1.070E-1
 1 20
11 GO:0042169 SH2 domain binding 9.078E-3 1.650E-2
5.938E-2
1.816E-1
 1 34
12 GO:0015485 cholesterol binding 1.147E-2 1.912E-2
6.877E-2
2.294E-1
 1 43
13 GO:0032934 sterol binding 1.280E-2 1.969E-2
7.083E-2
2.559E-1
 1 48
14 GO:0043621 protein self-association 1.492E-2 2.131E-2
7.666E-2
2.983E-1
 1 56
15 GO:0019905 syntaxin binding 2.599E-2 3.353E-2
1.206E-1
5.197E-1
 1 98
16 GO:0005496 steroid binding 2.730E-2 3.353E-2
1.206E-1
5.460E-1
 1 103
17 GO:0043178 alcohol binding 2.965E-2 3.353E-2
1.206E-1
5.931E-1
 1 112
18 GO:0030165 PDZ domain binding 3.018E-2 3.353E-2
1.206E-1
6.035E-1
 1 114
19 GO:0005179 hormone activity 3.279E-2 3.451E-2
1.242E-1
6.558E-1
 1 124
20 GO:0000149 SNARE binding 3.540E-2 3.540E-2
1.273E-1
7.079E-1
 1 134
Show 15 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 134 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007218 neuropeptide signaling pathway 3.234E-4 1.678E-2
9.193E-2
 4.333E-2 2 107
2 GO:0048499 synaptic vesicle membrane organization 5.369E-4 1.678E-2
9.193E-2
7.195E-2
 1 2
3 GO:2000474 regulation of opioid receptor signaling pathway 8.053E-4 1.678E-2
9.193E-2
1.079E-1
 1 3
4 GO:0007586 digestion 8.716E-4 1.678E-2
9.193E-2
1.168E-1
 2 176
5 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep 1.074E-3 1.678E-2
9.193E-2
1.439E-1
 1 4
6 GO:0007584 response to nutrient 1.226E-3 1.678E-2
9.193E-2
1.643E-1
 2 209
7 GO:0038169 somatostatin receptor signaling pathway 1.342E-3 1.678E-2
9.193E-2
1.798E-1
 1 5
8 GO:0038170 somatostatin signaling pathway 1.342E-3 1.678E-2
9.193E-2
1.798E-1
 1 5
9 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness 1.342E-3 1.678E-2
9.193E-2
1.798E-1
 1 5
10 GO:0008628 hormone-mediated apoptotic signaling pathway 1.342E-3 1.678E-2
9.193E-2
1.798E-1
 1 5
11 GO:0009755 hormone-mediated signaling pathway 1.469E-3 1.678E-2
9.193E-2
1.969E-1
 2 229
12 GO:0003105 negative regulation of glomerular filtration 1.610E-3 1.678E-2
9.193E-2
2.157E-1
 1 6
13 GO:0042746 circadian sleep/wake cycle, wakefulness 1.878E-3 1.678E-2
9.193E-2
2.517E-1
 1 7
14 GO:0035811 negative regulation of urine volume 1.878E-3 1.678E-2
9.193E-2
2.517E-1
 1 7
15 GO:0010840 regulation of circadian sleep/wake cycle, wakefulness 1.878E-3 1.678E-2
9.193E-2
2.517E-1
 1 7
16 GO:0035814 negative regulation of renal sodium excretion 2.146E-3 1.797E-2
9.848E-2
2.876E-1
 1 8
17 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep 2.414E-3 1.882E-2
1.031E-1
3.235E-1
 1 9
18 GO:0016188 synaptic vesicle maturation 2.682E-3 1.882E-2
1.031E-1
3.594E-1
 1 10
19 GO:0030432 peristalsis 2.682E-3 1.882E-2
1.031E-1
3.594E-1
 1 10
20 GO:0038003 opioid receptor signaling pathway 2.950E-3 1.882E-2
1.031E-1
3.953E-1
 1 11
21 GO:0042747 circadian sleep/wake cycle, REM sleep 2.950E-3 1.882E-2
1.031E-1
3.953E-1
 1 11
22 GO:0003093 regulation of glomerular filtration 3.218E-3 1.960E-2
1.074E-1
4.312E-1
 1 12
23 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep 3.486E-3 2.031E-2
1.113E-1
4.671E-1
 1 13
24 GO:0048172 regulation of short-term neuronal synaptic plasticity 4.289E-3 2.395E-2
1.312E-1
5.747E-1
 1 16
25 GO:0001977 renal system process involved in regulation of blood volume 4.824E-3 2.586E-2
1.417E-1
6.464E-1
 1 18
26 GO:0014821 phasic smooth muscle contraction 5.359E-3 2.744E-2
1.503E-1
7.181E-1
 1 20
27 GO:0010447 response to acidic pH 5.893E-3 2.744E-2
1.503E-1
7.897E-1
 1 22
28 GO:0035809 regulation of urine volume 6.161E-3 2.744E-2
1.503E-1
8.255E-1
 1 23
29 GO:0042493 response to drug 6.322E-3 2.744E-2
1.503E-1
8.471E-1
 2 481
30 GO:0003094 glomerular filtration 6.428E-3 2.744E-2
1.503E-1
8.613E-1
 1 24
31 GO:0097205 renal filtration 6.695E-3 2.744E-2
1.503E-1
8.971E-1
 1 25
32 GO:0035812 renal sodium excretion 6.962E-3 2.744E-2
1.503E-1
9.329E-1
 1 26
33 GO:0035813 regulation of renal sodium excretion 6.962E-3 2.744E-2
1.503E-1
9.329E-1
 1 26
34 GO:0006972 hyperosmotic response 6.962E-3 2.744E-2
1.503E-1
9.329E-1
 1 26
35 GO:0042753 positive regulation of circadian rhythm 7.229E-3 2.768E-2
1.516E-1
9.687E-1
 1 27
36 GO:0003071 renal system process involved in regulation of systemic arterial blood pressure 7.496E-3 2.770E-2
1.518E-1
1.000E0
 1 28
37 GO:0045187 regulation of circadian sleep/wake cycle, sleep 7.763E-3 2.770E-2
1.518E-1
1.000E0
 1 29
38 GO:0048520 positive regulation of behavior 8.030E-3 2.770E-2
1.518E-1
1.000E0
 1 30
39 GO:0042749 regulation of circadian sleep/wake cycle 8.296E-3 2.770E-2
1.518E-1
1.000E0
 1 31
40 GO:0050802 circadian sleep/wake cycle, sleep 8.563E-3 2.770E-2
1.518E-1
1.000E0
 1 32
41 GO:0044062 regulation of excretion 8.563E-3 2.770E-2
1.518E-1
1.000E0
 1 32
42 GO:0071392 cellular response to estradiol stimulus 8.830E-3 2.770E-2
1.518E-1
1.000E0
 1 33
43 GO:0048169 regulation of long-term neuronal synaptic plasticity 9.096E-3 2.770E-2
1.518E-1
1.000E0
 1 34
44 GO:0022410 circadian sleep/wake cycle process 9.096E-3 2.770E-2
1.518E-1
1.000E0
 1 34
45 GO:0042745 circadian sleep/wake cycle 9.896E-3 2.947E-2
1.614E-1
1.000E0
 1 37
46 GO:0098801 regulation of renal system process 1.096E-2 3.193E-2
1.749E-1
1.000E0
 1 41
47 GO:0045907 positive regulation of vasoconstriction 1.176E-2 3.283E-2
1.799E-1
1.000E0
 1 44
48 GO:0030431 sleep 1.176E-2 3.283E-2
1.799E-1
1.000E0
 1 44
49 GO:0009268 response to pH 1.229E-2 3.294E-2
1.805E-1
1.000E0
 1 46
50 GO:0071391 cellular response to estrogen stimulus 1.229E-2 3.294E-2
1.805E-1
1.000E0
 1 46
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 20 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030285 integral component of synaptic vesicle membrane 1.835E-3 3.670E-2
1.320E-1
 3.670E-2 1 7

4: Human Phenotype [Display Chart] 1 input genes in category / 0 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 98 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0010778 abnormal stomach fundus morphology 9.655E-4 3.612E-2
1.867E-1
9.462E-2
 1 2
2 MP:0008002 hyperchlorhydria 9.655E-4 3.612E-2
1.867E-1
9.462E-2
 1 2
3 MP:0005117 increased circulating pituitary hormone level 1.238E-3 3.612E-2
1.867E-1
1.213E-1
 2 117
4 MP:0003973 increased pituitary hormone level 1.644E-3 3.612E-2
1.867E-1
1.611E-1
 2 135
5 MP:0011612 increased circulating ghrelin level 2.894E-3 3.612E-2
1.867E-1
2.836E-1
 1 6
6 MP:0005116 abnormal circulating pituitary hormone level 3.196E-3 3.612E-2
1.867E-1
3.132E-1
 2 189
7 MP:0002911 abnormal inhibitory postsynaptic potential 3.858E-3 3.612E-2
1.867E-1
3.780E-1
 1 8
8 MP:0004731 increased circulating gastrin level 3.858E-3 3.612E-2
1.867E-1
3.780E-1
 1 8
9 MP:0001408 stereotypic behavior 4.307E-3 3.612E-2
1.867E-1
4.221E-1
 2 220
10 MP:0011611 abnormal circulating ghrelin level 4.339E-3 3.612E-2
1.867E-1
4.252E-1
 1 9
11 MP:0004730 abnormal circulating gastrin level 4.339E-3 3.612E-2
1.867E-1
4.252E-1
 1 9
12 MP:0003965 abnormal pituitary hormone level 4.423E-3 3.612E-2
1.867E-1
4.335E-1
 2 223
13 MP:0002922 decreased post-tetanic potentiation 6.263E-3 4.529E-2
2.340E-1
6.137E-1
 1 13
14 MP:0005123 increased circulating growth hormone level 8.183E-3 4.529E-2
2.340E-1
8.020E-1
 1 17
15 MP:0001748 increased circulating adrenocorticotropin level 8.183E-3 4.529E-2
2.340E-1
8.020E-1
 1 17
16 MP:0004494 abnormal synaptic glutamate release 8.663E-3 4.529E-2
2.340E-1
8.490E-1
 1 18
17 MP:0005121 decreased circulating prolactin level 8.663E-3 4.529E-2
2.340E-1
8.490E-1
 1 18
18 MP:0006074 abnormal retinal rod bipolar cell morphology 9.142E-3 4.529E-2
2.340E-1
8.960E-1
 1 19
19 MP:0005137 increased growth hormone level 1.010E-2 4.529E-2
2.340E-1
9.899E-1
 1 21
20 MP:0002921 abnormal post-tetanic potentiation 1.010E-2 4.529E-2
2.340E-1
9.899E-1
 1 21
21 MP:0003883 enlarged stomach 1.058E-2 4.529E-2
2.340E-1
1.000E0
 1 22
22 MP:0002272 abnormal nervous system electrophysiology 1.118E-2 4.529E-2
2.340E-1
1.000E0
 2 359
23 MP:0001412 excessive scratching 1.154E-2 4.529E-2
2.340E-1
1.000E0
 1 24
24 MP:0005129 increased adrenocorticotropin level 1.154E-2 4.529E-2
2.340E-1
1.000E0
 1 24
25 MP:0003212 increased susceptibility to age related obesity 1.202E-2 4.529E-2
2.340E-1
1.000E0
 1 25
26 MP:0005138 decreased prolactin level 1.202E-2 4.529E-2
2.340E-1
1.000E0
 1 25
27 MP:0004139 abnormal gastric parietal cell morphology 1.297E-2 4.592E-2
2.373E-1
1.000E0
 1 27
28 MP:0002064 seizures 1.312E-2 4.592E-2
2.373E-1
1.000E0
 2 390
29 MP:0002920 decreased paired-pulse facilitation 1.393E-2 4.706E-2
2.432E-1
1.000E0
 1 29
30 MP:0003038 decreased myocardial infarction size 1.440E-2 4.706E-2
2.432E-1
1.000E0
 1 30
31 MP:0000501 abnormal digestive secretion 1.584E-2 4.977E-2
2.572E-1
1.000E0
 1 33
32 MP:0003970 abnormal prolactin level 1.631E-2 4.977E-2
2.572E-1
1.000E0
 1 34
33 MP:0002965 increased circulating serum albumin level 1.727E-2 4.977E-2
2.572E-1
1.000E0
 1 36
34 MP:0003892 abnormal gastric gland morphology 1.727E-2 4.977E-2
2.572E-1
1.000E0
 1 36
Show 29 more annotations

6: Domain [Display Chart] 5 input genes in category / 15 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR028714 SYP InterPro 2.669E-4 8.895E-4 2.952E-3 4.003E-3 1 1
2 IPR002074 Somatstn rcpt 2 InterPro 2.669E-4 8.895E-4 2.952E-3 4.003E-3 1 1
3 IPR000670 Urot II rcpt InterPro 2.669E-4 8.895E-4 2.952E-3 4.003E-3 1 1
4 IPR001966 Gastrin pep rcpt InterPro 2.669E-4 8.895E-4 2.952E-3 4.003E-3 1 1
5 SM01381 7TM GPCR Srsx SMART 3.501E-4 8.895E-4 2.952E-3 5.251E-3 2 112
6 PF03002 Somatostatin Pfam 5.337E-4 8.895E-4 2.952E-3 8.006E-3 1 2
7 IPR018142 Somatostatin/Cortistatin C InterPro 5.337E-4 8.895E-4 2.952E-3 8.006E-3 1 2
8 IPR004250 Somatostatin InterPro 5.337E-4 8.895E-4 2.952E-3 8.006E-3 1 2
9 PS00604 SYNAPTOP PROSITE 5.337E-4 8.895E-4 2.952E-3 8.006E-3 1 2
10 IPR001556 Bombsn rcpt-like InterPro 8.005E-4 1.201E-3 3.984E-3 1.201E-2 1 3
11 IPR001285 Synaptophysin/porin InterPro 1.067E-3 1.455E-3 4.829E-3 1.601E-2 1 4
12 IPR000586 Somatstn rcpt InterPro 1.334E-3 1.667E-3 5.532E-3 2.001E-2 1 5
13 PF01284 MARVEL Pfam 7.186E-3 7.451E-3 2.472E-2
1.078E-1
 1 27
14 IPR008253 Marvel InterPro 7.451E-3 7.451E-3 2.472E-2
1.118E-1
 1 28
15 PS51225 MARVEL PROSITE 7.451E-3 7.451E-3 2.472E-2
1.118E-1
 1 28
Show 10 more annotations

7: Pathway [Display Chart] 5 input genes in category / 24 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269546 Peptide ligand-binding receptors BioSystems: REACTOME 2.489E-7 5.974E-6 2.256E-5 5.974E-6 4 188
2 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 2.152E-6 2.582E-5 9.751E-5 5.165E-5 4 322
3 1269544 GPCR ligand binding BioSystems: REACTOME 8.551E-6 6.841E-5 2.583E-4 2.052E-4 4 455
4 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 1.065E-4 6.393E-4 2.414E-3 2.557E-3 3 278
5 154409 Gastric acid secretion BioSystems: KEGG 3.539E-4 1.699E-3 6.414E-3 8.494E-3 2 75
6 1269578 G alpha (q) signalling events BioSystems: REACTOME 2.295E-3 8.255E-3 3.117E-2
5.507E-2
 2 192
7 PW:0000579 somatostatin signaling Pathway Ontology 2.408E-3 8.255E-3 3.117E-2
5.778E-2
 1 6
8 1269576 G alpha (i) signalling events BioSystems: REACTOME 3.649E-3 9.612E-3 3.630E-2
8.759E-2
 2 243
9 SMP00246 Pirenzepine Pathway SMPDB 6.810E-3 9.612E-3 3.630E-2
1.634E-1
 1 17
10 SMP00232 Cimetidine Pathway SMPDB 6.810E-3 9.612E-3 3.630E-2
1.634E-1
 1 17
11 SMP00225 Esomeprazole Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
12 SMP00229 Rabeprazole Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
13 SMP00227 Lansoprazole Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
14 SMP00228 Pantoprazole Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
15 SMP00226 Omeprazole Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
16 SMP00230 Ranitidine Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
17 SMP00231 Famotidine Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
18 SMP00233 Nizatidine Pathway SMPDB 7.209E-3 9.612E-3 3.630E-2
1.730E-1
 1 18
19 P05734 Synaptic vesicle trafficking PantherDB 9.204E-3 1.163E-2 4.390E-2
2.209E-1
 1 23
20 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 1.192E-2 1.430E-2
5.399E-2
2.860E-1
 2 446
Show 15 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 1533 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18617261 Somatostatin as a regulator of first-trimester human trophoblast functions. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
2 11823046 Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
3 12676656 Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
4 25406263 Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
5 23913690 Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
6 22932785 SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
7 12115637 Somatostatin is expressed in the murine thymus and enhances thymocyte development. Pubmed 1.371E-8 3.003E-6 2.376E-5 2.102E-5 2 2
8 20056831 Kit ligand and the somatostatin receptor antagonist, BIM-23627, stimulate in vitro resting follicle growth in the neonatal mouse ovary. Pubmed 4.113E-8 5.255E-6 4.158E-5 6.305E-5 2 3
9 12684217 Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells. Pubmed 4.113E-8 5.255E-6 4.158E-5 6.305E-5 2 3
10 23831358 Somatostatin and its receptors: functional regulation in the development of mice Sertoli cells. Pubmed 4.113E-8 5.255E-6 4.158E-5 6.305E-5 2 3
11 19106227 Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes. Pubmed 4.113E-8 5.255E-6 4.158E-5 6.305E-5 2 3
12 11920268 Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2. Pubmed 4.113E-8 5.255E-6 4.158E-5 6.305E-5 2 3
13 12759718 Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain. Pubmed 1.371E-7 1.617E-5 1.279E-4 2.102E-4 2 5
14 19423539 Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. Pubmed 2.056E-7 1.854E-5 1.467E-4 3.152E-4 2 6
15 1346068 Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Pubmed 2.056E-7 1.854E-5 1.467E-4 3.152E-4 2 6
16 12145348 Brain somatostatin receptors are up-regulated in somatostatin-deficient mice. Pubmed 2.056E-7 1.854E-5 1.467E-4 3.152E-4 2 6
17 16606630 Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. Pubmed 2.056E-7 1.854E-5 1.467E-4 3.152E-4 2 6
18 22581439 Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. Pubmed 2.879E-7 2.323E-5 1.838E-4 4.413E-4 2 7
19 18206294 Null mutant mouse models of somatostatin and cortistatin, and their receptors. Pubmed 2.879E-7 2.323E-5 1.838E-4 4.413E-4 2 7
20 16214911 Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. Pubmed 6.167E-7 4.727E-5 3.741E-4 9.455E-4 2 10
21 17804764 MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Pubmed 7.538E-7 5.502E-5 4.354E-4 1.156E-3 2 11
22 15548585 GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development. Pubmed 9.045E-7 6.302E-5 4.987E-4 1.387E-3 2 12
23 21048147 Developmental origin of preBötzinger complex respiratory neurons. Pubmed 1.247E-6 7.877E-5 6.233E-4 1.912E-3 2 14
24 9584121 Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Pubmed 1.247E-6 7.877E-5 6.233E-4 1.912E-3 2 14
25 18240029 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Pubmed 1.404E-6 7.877E-5 6.233E-4 2.152E-3 3 200
26 25652387 SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Pubmed 1.439E-6 7.877E-5 6.233E-4 2.206E-3 2 15
27 11739954 Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Pubmed 1.439E-6 7.877E-5 6.233E-4 2.206E-3 2 15
28 19022256 Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Pubmed 1.439E-6 7.877E-5 6.233E-4 2.206E-3 2 15
29 20148032 Rfx6 directs islet formation and insulin production in mice and humans. Pubmed 2.096E-6 1.071E-4 8.475E-4 3.213E-3 2 18
30 20810604 Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. Pubmed 2.096E-6 1.071E-4 8.475E-4 3.213E-3 2 18
31 24027274 Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. Pubmed 2.343E-6 1.158E-4 9.166E-4 3.591E-3 2 19
32 22980982 Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Pubmed 3.780E-6 1.811E-4 1.433E-3 5.795E-3 2 24
33 26631740 Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells. Pubmed 4.108E-6 1.909E-4 1.510E-3 6.298E-3 2 25
34 20080794 Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Pubmed 4.451E-6 2.007E-4 1.588E-3 6.823E-3 2 26
35 16951258 The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Pubmed 5.176E-6 2.267E-4 1.794E-3 7.934E-3 2 28
36 19633665 The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Pubmed 5.559E-6 2.367E-4 1.873E-3 8.522E-3 2 29
37 27292642 Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function. Pubmed 5.956E-6 2.468E-4 1.952E-3 9.130E-3 2 30
38 28576773 Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Pubmed 9.115E-6 3.583E-4 2.835E-3 1.397E-2 2 37
39 26743624 Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Pubmed 9.115E-6 3.583E-4 2.835E-3 1.397E-2 2 37
40 20634197 Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Pubmed 2.501E-5 5.834E-4 4.616E-3 3.835E-2 2 61
41 22723691 Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord. Pubmed 4.315E-5 5.834E-4 4.616E-3
6.615E-2
 2 80
42 16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells. Pubmed 6.092E-5 5.834E-4 4.616E-3
9.339E-2
 2 95
43 11753230 [Somatostatin and its receptors. Role in the control of cell proliferation]. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
44 15601946 Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
45 16706848 Compensatory changes in the hippocampus of somatostatin knockout mice: upregulation of somatostatin receptor 2 and its function in the control of bursting activity and synaptic transmission. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
46 23966691 X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
47 17761762 Gender-dependent role of endogenous somatostatin in regulating growth hormone-axis function in mice. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
48 18682975 Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
49 10689196 Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
50 27338741 Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors. Pubmed 1.309E-4 5.834E-4 4.616E-3
2.007E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 117 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SST SST interactions 1.339E-6 1.567E-4 8.375E-4 1.567E-4 2 7
2 int:SSTR2 SSTR2 interactions 3.507E-6 2.051E-4 1.096E-3 4.103E-4 2 11
3 int:ARL5B ARL5B interactions 1.089E-5 4.248E-4 2.270E-3 1.274E-3 2 19
4 int:ARV1 ARV1 interactions 1.757E-5 5.139E-4 2.746E-3 2.056E-3 2 24
5 int:UTS2B UTS2B interactions 5.648E-4 1.322E-2
7.062E-2
6.608E-2
 1 2
6 int:UTS2 UTS2 interactions 8.471E-4 1.416E-2
7.566E-2
9.911E-2
 1 3
7 int:UTS2R UTS2R interactions 8.471E-4 1.416E-2
7.566E-2
9.911E-2
 1 3
8 int:TMEM183A TMEM183A interactions 1.129E-3 1.468E-2
7.845E-2
1.321E-1
 1 4
9 int:SSTR4 SSTR4 interactions 1.129E-3 1.468E-2
7.845E-2
1.321E-1
 1 4
10 int:GRP GRP interactions 1.412E-3 1.530E-2
8.175E-2
1.652E-1
 1 5
11 int:SSTR1 SSTR1 interactions 1.694E-3 1.530E-2
8.175E-2
1.982E-1
 1 6
12 int:SYNGR3 SYNGR3 interactions 2.258E-3 1.530E-2
8.175E-2
2.642E-1
 1 8
13 int:STMN3 STMN3 interactions 2.258E-3 1.530E-2
8.175E-2
2.642E-1
 1 8
14 int:METTL7B METTL7B interactions 2.258E-3 1.530E-2
8.175E-2
2.642E-1
 1 8
15 int:SSTR5 SSTR5 interactions 2.540E-3 1.530E-2
8.175E-2
2.971E-1
 1 9
16 int:CORT CORT interactions 2.822E-3 1.530E-2
8.175E-2
3.301E-1
 1 10
17 int:DPH6 DPH6 interactions 3.103E-3 1.530E-2
8.175E-2
3.631E-1
 1 11
18 int:PANX1 PANX1 interactions 3.385E-3 1.530E-2
8.175E-2
3.961E-1
 1 12
19 int:GNA14 GNA14 interactions 3.385E-3 1.530E-2
8.175E-2
3.961E-1
 1 12
20 int:SLC35G2 SLC35G2 interactions 3.385E-3 1.530E-2
8.175E-2
3.961E-1
 1 12
21 int:SLC6A8 SLC6A8 interactions 3.385E-3 1.530E-2
8.175E-2
3.961E-1
 1 12
22 int:RND2 RND2 interactions 3.667E-3 1.530E-2
8.175E-2
4.290E-1
 1 13
23 int:SLC38A10 SLC38A10 interactions 3.667E-3 1.530E-2
8.175E-2
4.290E-1
 1 13
24 int:FAR2 FAR2 interactions 3.948E-3 1.530E-2
8.175E-2
4.620E-1
 1 14
25 int:RNASEL RNASEL interactions 3.948E-3 1.530E-2
8.175E-2
4.620E-1
 1 14
26 int:SLC20A2 SLC20A2 interactions 4.230E-3 1.530E-2
8.175E-2
4.949E-1
 1 15
27 int:SSTR3 SSTR3 interactions 4.230E-3 1.530E-2
8.175E-2
4.949E-1
 1 15
28 int:CDS1 CDS1 interactions 4.230E-3 1.530E-2
8.175E-2
4.949E-1
 1 15
29 int:LMBRD2 LMBRD2 interactions 4.230E-3 1.530E-2
8.175E-2
4.949E-1
 1 15
30 int:TMEM164 TMEM164 interactions 4.793E-3 1.530E-2
8.175E-2
5.608E-1
 1 17
31 int:MTG1 MTG1 interactions 4.793E-3 1.530E-2
8.175E-2
5.608E-1
 1 17
32 int:ATP7B ATP7B interactions 5.074E-3 1.530E-2
8.175E-2
5.937E-1
 1 18
33 int:GPR50 GPR50 interactions 5.074E-3 1.530E-2
8.175E-2
5.937E-1
 1 18
34 int:SRCIN1 SRCIN1 interactions 5.074E-3 1.530E-2
8.175E-2
5.937E-1
 1 18
35 int:GJC1 GJC1 interactions 5.355E-3 1.530E-2
8.175E-2
6.266E-1
 1 19
36 int:SLC25A23 SLC25A23 interactions 5.355E-3 1.530E-2
8.175E-2
6.266E-1
 1 19
37 int:ABCB6 ABCB6 interactions 5.637E-3 1.530E-2
8.175E-2
6.595E-1
 1 20
38 int:KDELR3 KDELR3 interactions 5.637E-3 1.530E-2
8.175E-2
6.595E-1
 1 20
39 int:PDIA2 PDIA2 interactions 5.637E-3 1.530E-2
8.175E-2
6.595E-1
 1 20
40 int:PTS PTS interactions 5.918E-3 1.530E-2
8.175E-2
6.924E-1
 1 21
41 int:MFSD5 MFSD5 interactions 5.918E-3 1.530E-2
8.175E-2
6.924E-1
 1 21
42 int:SLC25A16 SLC25A16 interactions 5.918E-3 1.530E-2
8.175E-2
6.924E-1
 1 21
43 int:TMEM87A TMEM87A interactions 5.918E-3 1.530E-2
8.175E-2
6.924E-1
 1 21
44 int:FADS1 FADS1 interactions 6.199E-3 1.530E-2
8.175E-2
7.253E-1
 1 22
45 int:CBWD3 CBWD3 interactions 6.480E-3 1.530E-2
8.175E-2
7.582E-1
 1 23
46 int:SLC35B2 SLC35B2 interactions 6.761E-3 1.530E-2
8.175E-2
7.910E-1
 1 24
47 int:TMTC4 TMTC4 interactions 6.761E-3 1.530E-2
8.175E-2
7.910E-1
 1 24
48 int:EXT1 EXT1 interactions 7.042E-3 1.530E-2
8.175E-2
8.239E-1
 1 25
49 int:PRXL2A PRXL2A interactions 7.042E-3 1.530E-2
8.175E-2
8.239E-1
 1 25
50 int:HOMER2 HOMER2 interactions 7.042E-3 1.530E-2
8.175E-2
8.239E-1
 1 25
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xp11.23-p11.22 Xp11.23-p11.22 1.009E-3 3.604E-3 8.230E-3 5.047E-3 1 7
2 17q24 17q24 1.442E-3 3.604E-3 8.230E-3 7.209E-3 1 10
3 3q28 3q28 4.464E-3 7.440E-3 1.699E-2 2.232E-2 1 31
4 Xp22.2 Xp22.2 6.044E-3 7.555E-3 1.725E-2 3.022E-2 1 42
5 17q25.3 17q25.3 1.577E-2 1.577E-2 3.600E-2
7.884E-2
 1 110

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 32 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$CREB Q4 V$CREB Q4 2.508E-3 3.079E-2
1.250E-1
8.024E-2
 2 203
2 V$CREB Q2 V$CREB Q2 2.606E-3 3.079E-2
1.250E-1
8.340E-2
 2 207
3 V$ATF 01 V$ATF 01 2.887E-3 3.079E-2
1.250E-1
9.238E-2
 2 218

12: Gene Family [Display Chart] 4 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 222 Bombesin receptors genenames.org 6.594E-4 2.198E-3 4.579E-3 2.638E-3 1 3
2 257 Somatostatin receptors genenames.org 1.099E-3 2.198E-3 4.579E-3 4.396E-3 1 5
3 103 X-linked mental retardation|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 1.921E-2 2.561E-2
5.336E-2
7.683E-2
 1 88

13: Coexpression [Display Chart] 5 input genes in category / 295 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M2002 Genes with high-CpG-density promoters (HCP) without H3 methylation marks at K4 and K27 in embryonic stem cells (ES). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.916E-7 5.654E-5 3.543E-4 5.654E-5 3 63
2 M6920 Genes up-regulated in the nucleus accumbens (a major reward center in the brain) 8 weeks after induction of CREB1 [GeneID=1385] expression in a transgenic Tet-Off system. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.785E-7 1.148E-4 7.195E-4 2.297E-4 3 100
3 15808516-Table2 Rat Lung not cancer Balharry05 31genes GeneSigDB 1.119E-5 1.100E-3 6.892E-3 3.300E-3 2 25
4 19305503-Table2 Rat Brain Greco09 84genes GeneSigDB 1.143E-4 6.919E-3 4.335E-2 3.373E-2 2 79
5 M1968 Genes with high-CpG-density promoters (HCP) without H3 methylation marks at either H3K4 or H3K27 in MCV8.1 cells (induced pluripotent cells, iPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.173E-4 6.919E-3 4.335E-2 3.459E-2 2 80
6 M2644 Genes up-regulated in BJAB (lymphoma) cells by rapamycin (sirolimus) [PubChem = 6610346]. MSigDB C6: Oncogenic Signatures (v6.0) 6.125E-4 1.659E-2
1.039E-1
1.807E-1
 2 183
7 M15912 Genes down-regulated in T1 cells (primary melanoma, sensitive to TRAIL [GeneID=8743]) compared to G1 cells (metastatic melanoma, resistant to TRAIL). MSigDB C2: CGP Curated Gene Sets (v6.0) 6.327E-4 1.659E-2
1.039E-1
1.866E-1
 2 186
8 M9228 Genes up-regulated in CD8 T cells: wildtype versus STAT4 [GeneID=6775] knockout. MSigDB C7: Immunologic Signatures (v6.0) 6.600E-4 1.659E-2
1.039E-1
1.947E-1
 2 190
9 M8872 Genes up-regulated in common lymphoid progenitors versus RAG2 [GeneID=5897] knockout NK cells. MSigDB C7: Immunologic Signatures (v6.0) 7.021E-4 1.659E-2
1.039E-1
2.071E-1
 2 196
10 M5161 Genes down-regulated in comparison of macrophages versus macrophages exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 7.092E-4 1.659E-2
1.039E-1
2.092E-1
 2 197
11 M6645 Genes up-regulated in bone marrow-derived macrophages at 45 min of stimulation by IL6 [GeneID=3469] and LPS: wildtype versus IL6 [GeneID=3469] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.659E-2
1.039E-1
2.135E-1
 2 199
12 M3962 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.659E-2
1.039E-1
2.156E-1
 2 200
13 M5393 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 48 h versus neutrophils stimulated with LPS (TLR4 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.659E-2
1.039E-1
2.156E-1
 2 200
14 M2020 Genes with high-CpG-density promoters (HCP) with unmethylated histone H3 in MEF cells (embryonic fibroblast). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.481E-4 1.998E-2
1.252E-1
2.797E-1
 2 228
15 M15936 Genes within amplicon 17q21-q25 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.031E-3 3.994E-2
2.502E-1
5.991E-1
 2 335
16 19305503-TableS1 Rat Brain Greco09 425genes GeneSigDB 2.699E-3 4.729E-2
2.963E-1
7.962E-1
 2 387
17 12067990-Table3 Human Ovarian Bayani02 26genes GeneSigDB 3.238E-3 4.729E-2
2.963E-1
9.551E-1
 1 15
18 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 3.823E-3 4.729E-2
2.963E-1
1.000E0
 2 462
19 15958054-Table2 Human Stomach Yanagihara05 35genes GeneSigDB 4.746E-3 4.729E-2
2.963E-1
1.000E0
 1 22
20 18288401-Table3 Human Stomach Yang07 22genes GeneSigDB 4.746E-3 4.729E-2
2.963E-1
1.000E0
 1 22
21 M5519 Genes down-regulated in NIH-3T3 cells (fibroblast) after knockdown of PRMT5 [GeneID=10419] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.252E-3 4.729E-2
2.963E-1
1.000E0
 1 29
22 18172295-Table3 Human Bone Heller08 43genes GeneSigDB 6.252E-3 4.729E-2
2.963E-1
1.000E0
 1 29
23 16178058-Table5 Human Brain Coco05 32genes GeneSigDB 6.682E-3 4.729E-2
2.963E-1
1.000E0
 1 31
24 M2426 Genes translationally up-regulated in HUVEC cells (endothelium) grown on FN1 [GeneID=2335] compared to those grown on laminin 1. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.541E-3 4.729E-2
2.963E-1
1.000E0
 1 35
25 M11749 Genes up-regulated in SCLC (small cell lung cancer) cells with acquired resistance to ABT-737 [PubChem=11228183], an inhibitor of the BCL2 [GeneID=596] family proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.756E-3 4.729E-2
2.963E-1
1.000E0
 1 36
26 M2460 Genes downregulated in the postnatal day 3 pancreata with impaired function of GLIS3 [GeneID=169792]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.971E-3 4.729E-2
2.963E-1
1.000E0
 1 37
27 15467184-Table1a Human Stomach Lee04 37genes GeneSigDB 7.971E-3 4.729E-2
2.963E-1
1.000E0
 1 37
28 M347 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and H2O2 [PubChem=5283344;784]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.400E-3 4.729E-2
2.963E-1
1.000E0
 1 39
29 M5957 Genes specifically up-regulated in pancreatic beta cells. MSigDB H: Hallmark Gene Sets (v6.0) 8.615E-3 4.729E-2
2.963E-1
1.000E0
 1 40
30 M2003 Genes with intermediate-CpG-density promoters (ICP) bearing histone H3 K27 trimethylation mark (H3K27me3) in embryonic stem cells (ES). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.044E-3 4.729E-2
2.963E-1
1.000E0
 1 42
31 16232197-Table2 Human Lung Peng05 62genes GeneSigDB 9.473E-3 4.729E-2
2.963E-1
1.000E0
 1 44
32 M8556 Genes up-regulated in A549 cells (lung cancer) upon expression of ASCL1 [GeneID=429] off a viral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.902E-3 4.729E-2
2.963E-1
1.000E0
 1 46
33 M1668 Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls MSigDB C2: CGP Curated Gene Sets (v6.0) 1.012E-2 4.729E-2
2.963E-1
1.000E0
 1 47
34 18537973-SuppTable1b Human Lymphoma Miyazaki08 70genes GeneSigDB 1.033E-2 4.729E-2
2.963E-1
1.000E0
 1 48
35 M7669 Genes up-regulated in medulloblastoma tumors from animals with inactivating mutations of one copy of PTCH1 or SUFU [GeneID=5727;51684] in conjunction with TP53 [GeneID=7157] loss. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.140E-2 4.729E-2
2.963E-1
1.000E0
 1 53
36 15788657-Table3 Human Ovarian Shedden05 120genes GeneSigDB 1.269E-2 4.729E-2
2.963E-1
1.000E0
 1 59
37 M10332 Genes up-regulated in hyppocampus at late postnatal stages (clusters 11 and 15). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.354E-2 4.729E-2
2.963E-1
1.000E0
 1 63
38 18722011-SuppTable2l Human Leukemia Sanchez-Guijo08 66genes GeneSigDB 1.376E-2 4.729E-2
2.963E-1
1.000E0
 1 64
39 M2024 Genes up-regulated in mesenchymal stem cells during early phase of adipogenesis, defined as days 1 to 5 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.397E-2 4.729E-2
2.963E-1
1.000E0
 1 65
40 M16097 Genes whose CpG islands are hyper-methylated in the NB4 cell line (APL, acute promyelocytic leukemia) compared to PBMC (normal peripheral peripheral blood mononuclear cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.461E-2 4.729E-2
2.963E-1
1.000E0
 1 68
41 19530251 suppinfo6 Human Breast Rozenchan09 79genes GeneSigDB 1.461E-2 4.729E-2
2.963E-1
1.000E0
 1 68
42 M5370 Genes down-regulated in follicular thyroid adenoma (FTA) compared to other thyroid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.461E-2 4.729E-2
2.963E-1
1.000E0
 1 68
43 20161705-Table2 Mouse EmbryonicStemCell Layden10 73genes GeneSigDB 1.482E-2 4.729E-2
2.963E-1
1.000E0
 1 69
44 M1712 Genes enriched in neurons in the adult mouse brain identified through correlation-based searches seeded with neuron cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.482E-2 4.729E-2
2.963E-1
1.000E0
 1 69
45 19530251 suppinfo5 Human Breast Rozenchan09 90genes GeneSigDB 1.610E-2 4.729E-2
2.963E-1
1.000E0
 1 75
46 19799973-Table1 Human Leukemia Visser09 75genes GeneSigDB 1.610E-2 4.729E-2
2.963E-1
1.000E0
 1 75
47 21152935-TableS2 Human StemCell Koide10 79genes GeneSigDB 1.653E-2 4.729E-2
2.963E-1
1.000E0
 1 77
48 M1539 Genes up-regulated in the nucleus accumbens (a major reward center in the brain) after 5 days of cocaine [PubChem=5760] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.696E-2 4.729E-2
2.963E-1
1.000E0
 1 79
49 M14275 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to other thyroid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.717E-2 4.729E-2
2.963E-1
1.000E0
 1 80
50 M6154 Genes up-regulated in corneal fibroblasts after treatment with IL1A [GeneID=3552]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.738E-2 4.729E-2
2.963E-1
1.000E0
 1 81
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 453 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 PosteriorCortex Top 200 Genes BrainMap 2.419E-5 5.673E-3 3.798E-2 1.096E-2 3 296
2 BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Interneuron-selective Top 200 Genes BrainMap BrainAtlas - Human / Mouse Linnarsson Neuron Neuron Subtype Interneuron-selective Top 200 Genes BrainMap 2.913E-5 5.673E-3 3.798E-2 1.320E-2 3 315
3 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Pcdh11x Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Pcdh11x Top 200 Genes BrainMap 3.757E-5 5.673E-3 3.798E-2 1.702E-2 3 343
4 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Top 200 BrainMap 8.000E-5 9.060E-3
6.065E-2
 3.624E-2 3 442
5 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.2.1 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.2.1 Top 100 Genes 4.566E-4 1.457E-2
9.755E-2
2.068E-1
 2 149
6 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.1.1 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.1.1 Top 100 Genes 4.814E-4 1.457E-2
9.755E-2
2.181E-1
 2 153
7 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s11 immature neuro precursors Subtype immature neuro precursors s11 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s11 immature neuro precursors Subtype immature neuro precursors s11 Top 100 Genes 5.003E-4 1.457E-2
9.755E-2
2.267E-1
 2 156
8 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/1/0 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/1/0 TCGA-Esophagus 5.394E-4 1.457E-2
9.755E-2
2.443E-1
 2 162
9 Sample Type by Project: Shred 1/TCGA-Thryoid/Thyroid Papillary Carcinoma/Classical/4/0 Sample Type by Project: Shred 1/TCGA-Thryoid/Thyroid Papillary Carcinoma/Classical/4/0 TCGA-Thryoid 5.527E-4 1.457E-2
9.755E-2
2.504E-1
 2 164
10 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s4 immature neuro precursors Subtype immature neuro precursors s4 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors s4 immature neuro precursors Subtype immature neuro precursors s4 Top 100 Genes 5.799E-4 1.457E-2
9.755E-2
2.627E-1
 2 168
11 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 5.937E-4 1.457E-2
9.755E-2
2.690E-1
 2 170
12 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.2.3 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.2.3 Top 100 Genes 6.219E-4 1.457E-2
9.755E-2
2.817E-1
 2 174
13 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.1.4 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.1.4 Top 100 Genes 6.434E-4 1.457E-2
9.755E-2
2.914E-1
 2 177
14 Glioblastoma Single Cell Merged Neuron Top 200 Glioblastoma Single Cell Merged Neuron Top 200 7.101E-4 1.457E-2
9.755E-2
3.217E-1
 2 186
15 Glioblastoma Single Cell Merged Neuron Overall Top 200 Genes Glioblastoma Single Cell Merged Neuron Overall Top 200 Genes 7.101E-4 1.457E-2
9.755E-2
3.217E-1
 2 186
16 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Overall Top 200 Genes BrainMap 7.330E-4 1.457E-2
9.755E-2
3.321E-1
 2 189
17 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Top 200 BrainMap 7.330E-4 1.457E-2
9.755E-2
3.321E-1
 2 189
18 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Overall Top 200 Genes BrainMap 7.330E-4 1.457E-2
9.755E-2
3.321E-1
 2 189
19 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/4/0 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/4/0 TCGA-Brain 7.407E-4 1.457E-2
9.755E-2
3.356E-1
 2 190
20 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Overall Top 200 Genes BrainMap 7.485E-4 1.457E-2
9.755E-2
3.391E-1
 2 191
21 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/4 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/4 TCGA-Brain 7.642E-4 1.457E-2
9.755E-2
3.462E-1
 2 193
22 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligoastrocytoma/4 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligoastrocytoma/4 TCGA-Brain 7.721E-4 1.457E-2
9.755E-2
3.497E-1
 2 194
23 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 7.721E-4 1.457E-2
9.755E-2
3.497E-1
 2 194
24 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Astrocytoma/4 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Astrocytoma/4 TCGA-Brain 7.721E-4 1.457E-2
9.755E-2
3.497E-1
 2 194
25 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap 1.423E-3 2.578E-2
1.725E-1
6.444E-1
 2 264
26 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap 1.531E-3 2.668E-2
1.786E-1
6.936E-1
 2 274
27 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap 1.992E-3 2.812E-2
1.882E-1
9.023E-1
 2 313
28 JC iEC 2500 K2 JC iEC top-relative-expression-ranked 2500 k-means-cluster#2 PCBC 2.042E-3 2.812E-2
1.882E-1
9.252E-1
 2 317
29 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Crispld2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Crispld2 Top 200 Genes BrainMap 2.042E-3 2.812E-2
1.882E-1
9.252E-1
 2 317
30 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Gad1,Gad2 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Gad1,Gad2 Top 200 Genes 2.042E-3 2.812E-2
1.882E-1
9.252E-1
 2 317
31 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup2 Top 200 Genes BrainMap 2.106E-3 2.812E-2
1.882E-1
9.542E-1
 2 322
32 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 FrontalCortex Top 200 Genes BrainMap 2.158E-3 2.812E-2
1.882E-1
9.777E-1
 2 326
33 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap 2.171E-3 2.812E-2
1.882E-1
9.836E-1
 2 327
34 BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Striatum/Striatum/Neuron BrainMap/BrainAtlas - Mouse McCarroll/Tissue and Type by Type - Tissue vs Type (clevel sub)/Striatum/Striatum/Neuron BrainMap 2.289E-3 2.812E-2
1.882E-1
1.000E0
 1 10
35 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k2 100 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.289E-3 2.812E-2
1.882E-1
1.000E0
 1 10
36 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 FrontalCortex Top 200 Genes BrainMap 2.400E-3 2.812E-2
1.882E-1
1.000E0
 2 344
37 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cplx3,Reln Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cplx3,Reln Top 200 Genes BrainMap 2.400E-3 2.812E-2
1.882E-1
1.000E0
 2 344
38 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 Hippocampus Top 200 Genes BrainMap 2.413E-3 2.812E-2
1.882E-1
1.000E0
 2 345
39 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Slc5a7,Chat Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Slc5a7,Chat Top 200 Genes BrainMap 2.469E-3 2.812E-2
1.882E-1
1.000E0
 2 349
40 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6,Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6,Slc17a7 Top 200 Genes 2.483E-3 2.812E-2
1.882E-1
1.000E0
 2 350
41 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAc Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAc Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 2.596E-3 2.868E-2
1.920E-1
1.000E0
 2 358
42 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.800E-3 2.965E-2
1.985E-1
1.000E0
 2 372
43 StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s4 Top 200 Genes StanfordMouse+HumanSingleCells StanfordMouse+HumanSingleCells neuroblast- precursors neuroblast- precursors Subtype neuroblast- precursors s4 Top 200 Genes StanfordMouse+HumanSingleCells 2.814E-3 2.965E-2
1.985E-1
1.000E0
 2 373
44 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors Top 100 6mo cortical organoids wt 6mo cortical organoids wt Subtype immature neuro precursors Top 100 3.422E-3 3.379E-2
2.262E-1
1.000E0
 2 412
45 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 100 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.431E-3 3.379E-2
2.262E-1
1.000E0
 1 15
46 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k1 100 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.431E-3 3.379E-2
2.262E-1
1.000E0
 1 15
47 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.604E-3 3.474E-2
2.325E-1
1.000E0
 2 423
48 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 500 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.911E-3 3.691E-2
2.471E-1
1.000E0
 2 441
49 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 500 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.303E-3 3.959E-2
2.650E-1
1.000E0
 2 463
50 gudmap dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k2 200 dev lower uro neuro e14.5 BladdPelvicGanglion Sox10 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.573E-3 3.959E-2
2.650E-1
1.000E0
 1 20
Show 45 more annotations

15: Computational [Display Chart] 3 input genes in category / 20 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6672 MODULE 146 Genes in the cancer module 146. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.048E-4 6.096E-3 2.193E-2 6.096E-3 2 102

16: MicroRNA [Display Chart] 5 input genes in category / 88 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1182:PITA hsa-miR-1182:PITA TOP PITA 2.727E-5 2.400E-3 1.215E-2 2.400E-3 2 120
2 hsa-miR-720:PITA hsa-miR-720:PITA TOP PITA 1.453E-3 2.818E-2
1.426E-1
1.278E-1
 1 21
3 hsa-miR-191-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.729E-3 2.818E-2
1.426E-1
1.522E-1
 1 25
4 hsa-miR-3145-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 2.818E-2
1.426E-1
3.406E-1
 1 56
5 hsa-miR-769-5p:PITA hsa-miR-769-5p:PITA TOP PITA 5.732E-3 2.818E-2
1.426E-1
5.044E-1
 1 83
6 hsa-miR-345:PITA hsa-miR-345:PITA TOP PITA 7.040E-3 2.818E-2
1.426E-1
6.195E-1
 1 102
7 hsa-miR-564:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.659E-3 2.818E-2
1.426E-1
6.740E-1
 1 111
8 hsa-miR-720:mirSVR highEffct hsa-miR-720:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.659E-3 2.818E-2
1.426E-1
6.740E-1
 1 111
9 hsa-miR-423-5p:PITA hsa-miR-423-5p:PITA TOP PITA 8.141E-3 2.818E-2
1.426E-1
7.164E-1
 1 118
10 CCTGTGA,MIR-513:MSigDB CCTGTGA,MIR-513:MSigDB MSigDB 8.141E-3 2.818E-2
1.426E-1
7.164E-1
 1 118
11 hsa-miR-876-3p:PITA hsa-miR-876-3p:PITA TOP PITA 8.484E-3 2.818E-2
1.426E-1
7.466E-1
 1 123
12 hsa-miR-3120-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.828E-3 2.818E-2
1.426E-1
7.769E-1
 1 128
13 hsa-miR-608:PITA hsa-miR-608:PITA TOP PITA 9.309E-3 2.818E-2
1.426E-1
8.192E-1
 1 135
14 hsa-miR-4680-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.996E-3 2.818E-2
1.426E-1
8.796E-1
 1 145
15 GTGACTT,MIR-224:MSigDB GTGACTT,MIR-224:MSigDB MSigDB 1.034E-2 2.818E-2
1.426E-1
9.098E-1
 1 150
16 hsa-miR-4695-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-2 2.818E-2
1.426E-1
9.340E-1
 1 154
17 hsa-miR-7158-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.082E-2 2.818E-2
1.426E-1
9.521E-1
 1 157
18 hsa-miR-369-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.123E-2 2.818E-2
1.426E-1
9.883E-1
 1 163
19 hsa-miR-6736-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.123E-2 2.818E-2
1.426E-1
9.883E-1
 1 163
20 hsa-miR-4701-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.123E-2 2.818E-2
1.426E-1
9.883E-1
 1 163
21 hsa-miR-486-3p:PITA hsa-miR-486-3p:PITA TOP PITA 1.130E-2 2.818E-2
1.426E-1
9.944E-1
 1 164
22 hsa-miR-545-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.137E-2 2.818E-2
1.426E-1
1.000E0
 1 165
23 hsa-miR-1262:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.137E-2 2.818E-2
1.426E-1
1.000E0
 1 165
24 hsa-miR-5197-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.137E-2 2.818E-2
1.426E-1
1.000E0
 1 165
25 hsa-miR-1207-5p:PITA hsa-miR-1207-5p:PITA TOP PITA 1.178E-2 2.818E-2
1.426E-1
1.000E0
 1 171
26 hsa-miR-203b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.185E-2 2.818E-2
1.426E-1
1.000E0
 1 172
27 hsa-miR-17-3p:Functional MTI Functional MTI miRTarbase 1.192E-2 2.818E-2
1.426E-1
1.000E0
 1 173
28 hsa-miR-5692c:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.199E-2 2.818E-2
1.426E-1
1.000E0
 1 174
29 hsa-miR-5692b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.199E-2 2.818E-2
1.426E-1
1.000E0
 1 174
30 hsa-miR-4716-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.219E-2 2.818E-2
1.426E-1
1.000E0
 1 177
31 hsa-miR-6083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.226E-2 2.818E-2
1.426E-1
1.000E0
 1 178
32 hsa-miR-106a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.253E-2 2.818E-2
1.426E-1
1.000E0
 1 182
33 hsa-miR-6776-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.308E-2 2.818E-2
1.426E-1
1.000E0
 1 190
34 hsa-miR-219-2-3p:PITA hsa-miR-219-2-3p:PITA TOP PITA 1.308E-2 2.818E-2
1.426E-1
1.000E0
 1 190
35 hsa-miR-489:PITA hsa-miR-489:PITA TOP PITA 1.322E-2 2.818E-2
1.426E-1
1.000E0
 1 192
36 hsa-miR-614:mirSVR highEffct hsa-miR-614:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.411E-2 2.818E-2
1.426E-1
1.000E0
 1 205
37 hsa-miR-4781-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.438E-2 2.818E-2
1.426E-1
1.000E0
 1 209
38 hsa-miR-1227-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.452E-2 2.818E-2
1.426E-1
1.000E0
 1 211
39 CTGAGCC,MIR-24:MSigDB CTGAGCC,MIR-24:MSigDB MSigDB 1.486E-2 2.818E-2
1.426E-1
1.000E0
 1 216
40 hsa-miR-3663-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.493E-2 2.818E-2
1.426E-1
1.000E0
 1 217
41 hsa-miR-24:PITA hsa-miR-24:PITA TOP PITA 1.534E-2 2.818E-2
1.426E-1
1.000E0
 1 223
42 hsa-miR-122*:mirSVR highEffct hsa-miR-122*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.541E-2 2.818E-2
1.426E-1
1.000E0
 1 224
43 hsa-miR-588:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.548E-2 2.818E-2
1.426E-1
1.000E0
 1 225
44 hsa-miR-6131:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.554E-2 2.818E-2
1.426E-1
1.000E0
 1 226
45 hsa-miR-4659a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.582E-2 2.818E-2
1.426E-1
1.000E0
 1 230
46 hsa-miR-4659b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.582E-2 2.818E-2
1.426E-1
1.000E0
 1 230
47 hsa-miR-3187-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.602E-2 2.818E-2
1.426E-1
1.000E0
 1 233
48 hsa-miR-374b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.609E-2 2.818E-2
1.426E-1
1.000E0
 1 234
49 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 1.671E-2 2.818E-2
1.426E-1
1.000E0
 1 243
50 hsa-miR-6736-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.677E-2 2.818E-2
1.426E-1
1.000E0
 1 244
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 1644 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID003080866 ANB-NOS Stitch 8.907E-9 9.286E-6 7.413E-5 1.464E-5 3 23
2 CID000072127 AC1L2HGV Stitch 1.837E-8 9.286E-6 7.413E-5 3.020E-5 3 29
3 CID000119196 AN-201 Stitch 2.259E-8 9.286E-6 7.413E-5 3.714E-5 3 31
4 CID003081912 111In-pentetreotide Stitch 2.259E-8 9.286E-6 7.413E-5 3.714E-5 3 31
5 ctd:C106246 Edotreotide CTD 3.834E-8 1.261E-5 1.006E-4 6.303E-5 2 2
6 CID000023929 lutetium Stitch 6.651E-8 1.822E-5 1.455E-4 1.093E-4 3 44
7 CID000023947 rhenium Stitch 1.245E-7 2.924E-5 2.334E-4 2.047E-4 3 54
8 CID000195015 thsat Stitch 2.300E-7 3.756E-5 2.998E-4 3.781E-4 2 4
9 CID000011917 methyl centralite Stitch 2.300E-7 3.756E-5 2.998E-4 3.781E-4 2 4
10 CID000036511 Substance P Stitch 2.469E-7 3.756E-5 2.998E-4 4.060E-4 4 343
11 CID000071306 Vapreotide Stitch 2.513E-7 3.756E-5 2.998E-4 4.131E-4 3 68
12 CID006328526 AC1O3HA7 Stitch 5.749E-7 7.876E-5 6.287E-4 9.451E-4 2 6
13 CID005311025 BIM-23027 Stitch 8.047E-7 9.450E-5 7.543E-4 1.323E-3 2 7
14 CID005311026 Bim23268 Stitch 8.047E-7 9.450E-5 7.543E-4 1.323E-3 2 7
15 CID005492589 BIM 23034 Stitch 1.073E-6 1.031E-4 8.228E-4 1.764E-3 2 8
16 ctd:C042957 Ro 15-4513 CTD 1.073E-6 1.031E-4 8.228E-4 1.764E-3 2 8
17 CID003036100 Ee 581 Stitch 1.073E-6 1.031E-4 8.228E-4 1.764E-3 2 8
18 CID003081285 Cyclo Ss-8 Stitch 1.379E-6 1.031E-4 8.228E-4 2.268E-3 2 9
19 CID000123864 Tyr(3)-sms Stitch 1.379E-6 1.031E-4 8.228E-4 2.268E-3 2 9
20 CID000445281 X Bb Stitch 1.379E-6 1.031E-4 8.228E-4 2.268E-3 2 9
21 CID009898619 Depreotide Stitch 1.379E-6 1.031E-4 8.228E-4 2.268E-3 2 9
22 CID000194954 Hexapeptide 4 Stitch 1.379E-6 1.031E-4 8.228E-4 2.268E-3 2 9
23 CID000004802 NSC-694280 Stitch 1.665E-6 1.190E-4 9.501E-4 2.737E-3 3 127
24 CID005288161 AC1NRAYK Stitch 2.107E-6 1.443E-4 1.152E-3 3.464E-3 2 11
25 CID005487263 Ici 216140 Stitch 2.528E-6 1.662E-4 1.327E-3 4.156E-3 2 12
26 CID000121396 N-carbamylglutamate Stitch 2.987E-6 1.819E-4 1.452E-3 4.911E-3 2 13
27 CID000158782 Edotreotide Stitch 2.987E-6 1.819E-4 1.452E-3 4.911E-3 2 13
28 CID005311376 SRA 880 Stitch 3.485E-6 2.046E-4 1.633E-3 5.729E-3 2 14
29 CID005311375 L-817,818 Stitch 4.021E-6 2.279E-4 1.819E-3 6.610E-3 2 15
30 CID005311373 L-796,778 Stitch 4.595E-6 2.518E-4 2.010E-3 7.554E-3 2 16
31 ctd:C049109 zolpidem CTD 5.207E-6 2.761E-4 2.204E-3 8.560E-3 2 17
32 CID000084703 Zwittergent 3-12 Stitch 5.857E-6 2.832E-4 2.261E-3 9.629E-3 2 18
33 CID005311374 L-803,087 Stitch 5.857E-6 2.832E-4 2.261E-3 9.629E-3 2 18
34 CID000122080 Cycam Stitch 5.857E-6 2.832E-4 2.261E-3 9.629E-3 2 18
35 CID000055645 quinagolide Stitch 6.546E-6 3.075E-4 2.454E-3 1.076E-2 2 19
36 CID005311372 L-779,976 Stitch 8.037E-6 3.670E-4 2.930E-3 1.321E-2 2 21
37 CID000055472 loxtidine Stitch 8.840E-6 3.727E-4 2.975E-3 1.453E-2 2 22
38 CID000541551 N1-aminopropylagmatine Stitch 8.840E-6 3.727E-4 2.975E-3 1.453E-2 2 22
39 CID000060860 metaiodobenzylguanidine Stitch 8.840E-6 3.727E-4 2.975E-3 1.453E-2 2 22
40 CID005489061 AC1NUR1N Stitch 1.056E-5 4.340E-4 3.465E-3 1.736E-2 2 24
41 CID000127388 Rc 121 Stitch 1.243E-5 4.867E-4 3.885E-3 2.044E-2 2 26
42 CID000037419 butamifos Stitch 1.243E-5 4.867E-4 3.885E-3 2.044E-2 2 26
43 CID000071348 lanreotide Stitch 1.343E-5 5.017E-4 4.005E-3 2.207E-2 2 27
44 CID000022478 IBDU Stitch 1.343E-5 5.017E-4 4.005E-3 2.207E-2 2 27
45 CID000072128 dtpa-sms Stitch 1.446E-5 5.282E-4 4.216E-3 2.377E-2 2 28
46 CID000124326 NOTA Stitch 1.553E-5 5.550E-4 4.430E-3 2.553E-2 2 29
47 CID000122127 Rc-3095 Stitch 1.664E-5 5.581E-4 4.455E-3 2.735E-2 2 30
48 CID003016482 AC1MI32I Stitch 1.664E-5 5.581E-4 4.455E-3 2.735E-2 2 30
49 CID000164469 Tt 232 Stitch 1.664E-5 5.581E-4 4.455E-3 2.735E-2 2 30
50 CID000104916 CGS 8216 Stitch 2.019E-5 6.638E-4 5.298E-3 3.319E-2 2 33
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 237 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0031511 Pheochromocytoma DisGeNET Curated 4.492E-7 9.022E-5 5.456E-4 1.065E-4 4 283
2 C0037661 Somatostatinoma DisGeNET BeFree 7.614E-7 9.022E-5 5.456E-4 1.804E-4 2 5
3 C0030421 Paraganglioma DisGeNET Curated 1.286E-6 1.016E-4 6.144E-4 3.048E-4 3 83
4 C0334299 Carcinoid tumor no ICD-O subtype DisGeNET BeFree 2.399E-6 1.422E-4 8.596E-4 5.686E-4 3 102
5 C0017689 Glucagonoma DisGeNET Curated 6.921E-6 3.280E-4 1.984E-3 1.640E-3 2 14
6 C0007095 Carcinoid Tumor DisGeNET Curated 1.660E-5 5.082E-4 3.073E-3 3.934E-3 3 194
7 C0553665 Skin endocrine disorder DisGeNET BeFree 1.791E-5 5.082E-4 3.073E-3 4.246E-3 3 199
8 C0085648 Synovial Cyst DisGeNET BeFree 1.874E-5 5.082E-4 3.073E-3 4.440E-3 3 202
9 C1258666 Myxoid cyst DisGeNET BeFree 1.930E-5 5.082E-4 3.073E-3 4.573E-3 3 204
10 C0238462 Medullary carcinoma of thyroid DisGeNET Curated 2.985E-5 7.074E-4 4.278E-3 7.074E-3 3 236
11 C0017150 Gastrinoma DisGeNET Curated 3.529E-5 7.172E-4 4.337E-3 8.364E-3 2 31
12 C0206754 Neuroendocrine Tumors DisGeNET Curated 3.631E-5 7.172E-4 4.337E-3 8.607E-3 3 252
13 C0346302 Growth Hormone-Secreting Pituitary Adenoma DisGeNET Curated 4.778E-5 8.711E-4 5.268E-3 1.132E-2 2 36
14 C0032000 Pituitary Adenoma DisGeNET Curated 5.189E-5 8.785E-4 5.313E-3 1.230E-2 3 284
15 C0025261 Memory Disorders DisGeNET Curated 6.526E-5 1.031E-3 6.235E-3 1.547E-2 2 42
16 C0221406 Pituitary-dependent Cushing's disease DisGeNET Curated 8.543E-5 1.265E-3 7.652E-3 2.025E-2 2 48
17 C0010481 Cushing Syndrome DisGeNET Curated 1.004E-4 1.322E-3 7.992E-3 2.379E-2 2 52
18 C0017075 Ganglioneuroma DisGeNET Curated 1.004E-4 1.322E-3 7.992E-3 2.379E-2 2 52
19 C1337011 Well Differentiated Pancreatic Endocrine Tumor DisGeNET BeFree 1.207E-4 1.506E-3 9.108E-3 2.861E-2 2 57
20 C0740277 Bile duct carcinoma DisGeNET Curated 1.294E-4 1.533E-3 9.273E-3 3.067E-2 2 59
21 C0001206 Acromegaly DisGeNET Curated 1.930E-4 2.178E-3 1.317E-2 4.574E-2 2 72
22 C0033375 Prolactinoma DisGeNET Curated 2.505E-4 2.359E-3 1.427E-2
5.936E-2
 2 82
23 C0022602 Actinic keratosis DisGeNET BeFree 2.566E-4 2.359E-3 1.427E-2
6.082E-2
 2 83
24 C0494165 Secondary malignant neoplasm of liver DisGeNET BeFree 2.738E-4 2.359E-3 1.427E-2
6.490E-2
 3 497
25 C0339143 Thyroid associated opthalmopathies DisGeNET Curated 2.755E-4 2.359E-3 1.427E-2
6.530E-2
 2 86
26 C0001624 Adrenal Gland Neoplasms DisGeNET Curated 2.820E-4 2.359E-3 1.427E-2
6.682E-2
 2 87
27 OMIN:300802 MENTAL RETARDATION, X-LINKED, SYP-RELATED OMIM 3.085E-4 2.359E-3 1.427E-2
7.313E-2
 1 1
28 cv:C2749021 Mental retardation, X-linked 96 Clinical Variations 3.085E-4 2.359E-3 1.427E-2
7.313E-2
 1 1
29 C3275408 MENTAL RETARDATION, X-LINKED 96 DisGeNET Curated 3.085E-4 2.359E-3 1.427E-2
7.313E-2
 1 1
30 C0014849 Esophageal and Gastric Varices DisGeNET Curated 3.085E-4 2.359E-3 1.427E-2
7.313E-2
 1 1
31 C2985175 Extraventricular neurocytoma DisGeNET BeFree 3.085E-4 2.359E-3 1.427E-2
7.313E-2
 1 1
32 C0014474 Ependymoma DisGeNET Curated 5.359E-4 3.969E-3 2.400E-2
1.270E-1
 2 120
33 C0038220 Status Epilepticus DisGeNET Curated 5.539E-4 3.978E-3 2.406E-2
1.313E-1
 2 122
34 C1622510 Neurocytoma DisGeNET BeFree 9.254E-4 5.772E-3 3.490E-2
2.193E-1
 1 3
35 C1368041 Pancreatic Somatostatinoma DisGeNET BeFree 9.254E-4 5.772E-3 3.490E-2
2.193E-1
 1 3
36 C0751398 Familial Olivopontocerebellar Atrophy DisGeNET BeFree 9.254E-4 5.772E-3 3.490E-2
2.193E-1
 1 3
37 C2919194 Sporadic olivopontocerebellar atrophy DisGeNET BeFree 9.254E-4 5.772E-3 3.490E-2
2.193E-1
 1 3
38 C0279735 TSH secreting adenoma DisGeNET BeFree 9.254E-4 5.772E-3 3.490E-2
2.193E-1
 1 3
39 C0206686 Adrenocortical carcinoma DisGeNET Curated 1.010E-3 5.984E-3 3.619E-2
2.394E-1
 2 165
40 C0751396 Well Differentiated Oligodendroglioma DisGeNET BeFree 1.010E-3 5.984E-3 3.619E-2
2.394E-1
 2 165
41 C0028945 oligodendroglioma DisGeNET Curated 1.047E-3 6.051E-3 3.659E-2
2.481E-1
 2 168
42 C0021670 insulinoma DisGeNET Curated 1.227E-3 6.645E-3 4.019E-2
2.908E-1
 2 182
43 C3272528 Small Intestinal Neuroendocrine Tumor DisGeNET BeFree 1.234E-3 6.645E-3 4.019E-2
2.924E-1
 1 4
44 C2063389 Retroperitoneal liposarcoma DisGeNET BeFree 1.234E-3 6.645E-3 4.019E-2
2.924E-1
 1 4
45 C2845975 Malignant neuroendocrine tumor DisGeNET BeFree 1.542E-3 7.458E-3 4.510E-2
3.654E-1
 1 5
46 C1389102 Atrophic spinal cord DisGeNET Curated 1.542E-3 7.458E-3 4.510E-2
3.654E-1
 1 5
47 C0751689 Peripheral Nerve Sheath Neoplasm DisGeNET BeFree 1.542E-3 7.458E-3 4.510E-2
3.654E-1
 1 5
48 C0011993 Vipoma DisGeNET Curated 1.542E-3 7.458E-3 4.510E-2
3.654E-1
 1 5
49 C0524801 Retinal Neoplasms DisGeNET Curated 1.542E-3 7.458E-3 4.510E-2
3.654E-1
 1 5
50 C0206719 Central Neurocytoma DisGeNET BeFree 1.850E-3 8.598E-3
5.199E-2
4.385E-1
 1 6
Show 45 more annotations