Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc351_8, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 33 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004222 metalloendopeptidase activity 7.483E-4 9.668E-3 3.953E-2 2.469E-2 2 113
2 GO:0070053 thrombospondin receptor activity 1.500E-3 9.668E-3 3.953E-2 4.949E-2 1 4
3 GO:0005042 netrin receptor activity 1.500E-3 9.668E-3 3.953E-2 4.949E-2 1 4
4 GO:0070052 collagen V binding 1.500E-3 9.668E-3 3.953E-2 4.949E-2 1 4
5 GO:0008201 heparin binding 1.623E-3 9.668E-3 3.953E-2
5.357E-2
 2 167
6 GO:0070051 fibrinogen binding 1.874E-3 9.668E-3 3.953E-2
6.185E-2
 1 5
7 GO:0008237 metallopeptidase activity 2.051E-3 9.668E-3 3.953E-2
6.768E-2
 2 188
8 GO:0005539 glycosaminoglycan binding 2.770E-3 1.142E-2 4.671E-2
9.139E-2
 2 219
9 GO:1901681 sulfur compound binding 3.878E-3 1.422E-2
5.814E-2
1.280E-1
 2 260
10 GO:0030169 low-density lipoprotein particle binding 5.987E-3 1.976E-2
8.079E-2
1.976E-1
 1 16
11 GO:0050431 transforming growth factor beta binding 6.734E-3 2.020E-2
8.260E-2
2.222E-1
 1 18
12 GO:0071813 lipoprotein particle binding 9.714E-3 2.258E-2
9.232E-2
3.206E-1
 1 26
13 GO:0071814 protein-lipid complex binding 9.714E-3 2.258E-2
9.232E-2
3.206E-1
 1 26
14 GO:0017134 fibroblast growth factor binding 1.009E-2 2.258E-2
9.232E-2
3.328E-1
 1 27
15 GO:0004175 endopeptidase activity 1.158E-2 2.258E-2
9.232E-2
3.822E-1
 2 457
16 GO:0043236 laminin binding 1.194E-2 2.258E-2
9.232E-2
3.942E-1
 1 32
17 GO:0001786 phosphatidylserine binding 1.232E-2 2.258E-2
9.232E-2
4.064E-1
 1 33
18 GO:0001968 fibronectin binding 1.232E-2 2.258E-2
9.232E-2
4.064E-1
 1 33
19 GO:0043394 proteoglycan binding 1.306E-2 2.268E-2
9.273E-2
4.309E-1
 1 35
20 GO:0005109 frizzled binding 1.417E-2 2.338E-2
9.560E-2
4.676E-1
 1 38
21 GO:0050840 extracellular matrix binding 2.082E-2 3.272E-2
1.338E-1
6.871E-1
 1 56
22 GO:0005518 collagen binding 2.670E-2 3.936E-2
1.609E-1
8.812E-1
 1 72
23 GO:0072341 modified amino acid binding 2.743E-2 3.936E-2
1.609E-1
9.053E-1
 1 74
Show 18 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 396 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030198 extracellular matrix organization 4.294E-6 8.599E-4 5.641E-3 1.701E-3 4 354
2 GO:0043062 extracellular structure organization 4.343E-6 8.599E-4 5.641E-3 1.720E-3 4 355
3 GO:0036066 protein O-linked fucosylation 7.979E-6 1.053E-3 6.909E-3 3.160E-3 2 12
4 GO:0036065 fucosylation 3.329E-5 3.296E-3 2.162E-2 1.318E-2 2 24
5 GO:0002040 sprouting angiogenesis 3.229E-4 2.126E-2
1.395E-1
1.279E-1
 2 74
6 GO:0010754 negative regulation of cGMP-mediated signaling 3.759E-4 2.126E-2
1.395E-1
1.488E-1
 1 1
7 GO:0002605 negative regulation of dendritic cell antigen processing and presentation 3.759E-4 2.126E-2
1.395E-1
1.488E-1
 1 1
8 GO:0006493 protein O-linked glycosylation 6.127E-4 3.033E-2
1.990E-1
2.426E-1
 2 102
9 GO:0010752 regulation of cGMP-mediated signaling 7.516E-4 3.307E-2
2.169E-1
2.976E-1
 1 2
10 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1.127E-3 3.880E-2
2.545E-1
4.464E-1
 1 3
11 GO:0010751 negative regulation of nitric oxide mediated signal transduction 1.127E-3 3.880E-2
2.545E-1
4.464E-1
 1 3
12 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport 1.503E-3 3.880E-2
2.545E-1
5.951E-1
 1 4
13 GO:2001027 negative regulation of endothelial cell chemotaxis 1.503E-3 3.880E-2
2.545E-1
5.951E-1
 1 4
14 GO:0033564 anterior/posterior axon guidance 1.878E-3 3.880E-2
2.545E-1
7.438E-1
 1 5
15 GO:0010757 negative regulation of plasminogen activation 1.878E-3 3.880E-2
2.545E-1
7.438E-1
 1 5
16 GO:0010749 regulation of nitric oxide mediated signal transduction 1.878E-3 3.880E-2
2.545E-1
7.438E-1
 1 5
17 GO:1903036 positive regulation of response to wounding 2.059E-3 3.880E-2
2.545E-1
8.154E-1
 2 188
18 GO:0043652 engulfment of apoptotic cell 2.253E-3 3.880E-2
2.545E-1
8.924E-1
 1 6
19 GO:0002580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 2.253E-3 3.880E-2
2.545E-1
8.924E-1
 1 6
20 GO:0032914 positive regulation of transforming growth factor beta1 production 2.253E-3 3.880E-2
2.545E-1
8.924E-1
 1 6
21 GO:0038007 netrin-activated signaling pathway 2.253E-3 3.880E-2
2.545E-1
8.924E-1
 1 6
22 GO:0010746 regulation of plasma membrane long-chain fatty acid transport 2.253E-3 3.880E-2
2.545E-1
8.924E-1
 1 6
23 GO:0002578 negative regulation of antigen processing and presentation 2.253E-3 3.880E-2
2.545E-1
8.924E-1
 1 6
24 GO:1903960 negative regulation of anion transmembrane transport 3.004E-3 4.260E-2
2.795E-1
1.000E0
 1 8
25 GO:0015911 plasma membrane long-chain fatty acid transport 3.004E-3 4.260E-2
2.795E-1
1.000E0
 1 8
26 GO:0002604 regulation of dendritic cell antigen processing and presentation 3.004E-3 4.260E-2
2.795E-1
1.000E0
 1 8
27 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway 3.004E-3 4.260E-2
2.795E-1
1.000E0
 1 8
28 GO:0032908 regulation of transforming growth factor beta1 production 3.379E-3 4.260E-2
2.795E-1
1.000E0
 1 9
29 GO:2000192 negative regulation of fatty acid transport 3.379E-3 4.260E-2
2.795E-1
1.000E0
 1 9
30 GO:0002468 dendritic cell antigen processing and presentation 3.379E-3 4.260E-2
2.795E-1
1.000E0
 1 9
31 GO:0032905 transforming growth factor beta1 production 3.379E-3 4.260E-2
2.795E-1
1.000E0
 1 9
32 GO:0006909 phagocytosis 3.748E-3 4.260E-2
2.795E-1
1.000E0
 2 255
33 GO:0051918 negative regulation of fibrinolysis 3.753E-3 4.260E-2
2.795E-1
1.000E0
 1 10
34 GO:0008228 opsonization 4.128E-3 4.260E-2
2.795E-1
1.000E0
 1 11
35 GO:0010755 regulation of plasminogen activation 4.128E-3 4.260E-2
2.795E-1
1.000E0
 1 11
36 GO:0043413 macromolecule glycosylation 4.532E-3 4.260E-2
2.795E-1
1.000E0
 2 281
37 GO:0006486 protein glycosylation 4.532E-3 4.260E-2
2.795E-1
1.000E0
 2 281
38 GO:0019934 cGMP-mediated signaling 4.877E-3 4.260E-2
2.795E-1
1.000E0
 1 13
39 GO:0060670 branching involved in labyrinthine layer morphogenesis 4.877E-3 4.260E-2
2.795E-1
1.000E0
 1 13
40 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process 4.877E-3 4.260E-2
2.795E-1
1.000E0
 1 13
41 GO:0070085 glycosylation 4.884E-3 4.260E-2
2.795E-1
1.000E0
 2 292
42 GO:0051917 regulation of fibrinolysis 5.251E-3 4.260E-2
2.795E-1
1.000E0
 1 14
43 GO:0010759 positive regulation of macrophage chemotaxis 5.251E-3 4.260E-2
2.795E-1
1.000E0
 1 14
44 GO:2000052 positive regulation of non-canonical Wnt signaling pathway 5.251E-3 4.260E-2
2.795E-1
1.000E0
 1 14
45 GO:0010763 positive regulation of fibroblast migration 5.625E-3 4.260E-2
2.795E-1
1.000E0
 1 15
46 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 5.625E-3 4.260E-2
2.795E-1
1.000E0
 1 15
47 GO:0051895 negative regulation of focal adhesion assembly 5.625E-3 4.260E-2
2.795E-1
1.000E0
 1 15
48 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 6.000E-3 4.260E-2
2.795E-1
1.000E0
 1 16
49 GO:2000353 positive regulation of endothelial cell apoptotic process 6.000E-3 4.260E-2
2.795E-1
1.000E0
 1 16
50 GO:0071636 positive regulation of transforming growth factor beta production 6.000E-3 4.260E-2
2.795E-1
1.000E0
 1 16
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 20 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031012 extracellular matrix 9.616E-6 1.923E-4 6.919E-4 1.923E-4 4 444
2 GO:0005788 endoplasmic reticulum lumen 2.378E-3 2.201E-2
7.917E-2
 4.756E-2 2 207
3 GO:0005577 fibrinogen complex 3.301E-3 2.201E-2
7.917E-2
6.602E-2
 1 9
4 GO:0032809 neuronal cell body membrane 1.060E-2 4.241E-2
1.526E-1
2.121E-1
 1 29
5 GO:0044298 cell body membrane 1.060E-2 4.241E-2
1.526E-1
2.121E-1
 1 29

4: Human Phenotype [Display Chart] 2 input genes in category / 478 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002749 Osteomalacia 1.652E-4 2.539E-2
1.713E-1
7.898E-2
 2 61
2 HP:0002748 Rickets 2.118E-4 2.539E-2
1.713E-1
1.012E-1
 2 69
3 HP:0006344 Abnormality of primary molar morphology 4.249E-4 2.539E-2
1.713E-1
2.031E-1
 1 1
4 HP:0200094 Frontal open bite 4.249E-4 2.539E-2
1.713E-1
2.031E-1
 1 1
5 HP:0005332 Recurrent mandibular subluxations 4.249E-4 2.539E-2
1.713E-1
2.031E-1
 1 1
6 HP:0004876 Spontaneous neonatal pneumothorax 4.249E-4 2.539E-2
1.713E-1
2.031E-1
 1 1
7 HP:0010749 Blepharochalasis 4.249E-4 2.539E-2
1.713E-1
2.031E-1
 1 1
8 HP:0000222 Gingival hyperkeratosis 4.249E-4 2.539E-2
1.713E-1
2.031E-1
 1 1
9 HP:0100633 Esophagitis 7.224E-4 3.837E-2
2.589E-1
3.453E-1
 2 127
10 HP:0002107 Pneumothorax 9.039E-4 4.321E-2
2.915E-1
4.321E-1
 2 142
Show 5 more annotations

5: Mouse Phenotype [Display Chart] 7 input genes in category / 383 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001204 decreased sensitivity to skin irradiation 5.868E-6 2.248E-3 1.467E-2 2.248E-3 2 6
2 MP:0000556 abnormal hindlimb morphology 1.250E-4 1.741E-2
1.136E-1
 4.789E-2 4 464
3 MP:0003710 abnormal physiological neovascularization 1.364E-4 1.741E-2
1.136E-1
5.224E-2
 2 27
4 MP:0006143 increased systemic arterial diastolic blood pressure 3.491E-4 2.779E-2
1.814E-1
1.337E-1
 2 43
5 MP:0004875 increased mean systemic arterial blood pressure 4.354E-4 2.779E-2
1.814E-1
1.667E-1
 2 48
6 MP:0010878 increased trabecular bone volume 4.354E-4 2.779E-2
1.814E-1
1.667E-1
 2 48
7 MP:0001191 abnormal skin condition 5.555E-4 2.877E-2
1.878E-1
2.127E-1
 3 268
8 MP:0006266 decreased pulse pressure 6.760E-4 2.877E-2
1.878E-1
2.589E-1
 1 1
9 MP:0013623 increased femur compact bone thickness 6.760E-4 2.877E-2
1.878E-1
2.589E-1
 1 1
10 MP:0010875 increased bone volume 1.177E-3 4.314E-2
2.815E-1
4.509E-1
 2 79
11 MP:0004945 abnormal bone resorption 1.299E-3 4.314E-2
2.815E-1
4.974E-1
 2 83
12 MP:0005494 esophagogastric junction metaplasia 1.352E-3 4.314E-2
2.815E-1
5.177E-1
 1 2
Show 7 more annotations

6: Domain [Display Chart] 7 input genes in category / 84 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00090 TSP 1 Pfam 7.905E-15 2.018E-13 1.012E-12 6.640E-13 6 63
2 PS50092 TSP1 PROSITE 9.609E-15 2.018E-13 1.012E-12 8.071E-13 6 65
3 IPR000884 TSP1 rpt InterPro 9.609E-15 2.018E-13 1.012E-12 8.071E-13 6 65
4 SM00209 TSP1 SMART 9.609E-15 2.018E-13 1.012E-12 8.071E-13 6 65
5 IPR010294 ADAM spacer1 InterPro 3.016E-5 3.948E-4 1.979E-3 2.534E-3 2 23
6 PF05986 ADAM spacer1 Pfam 3.016E-5 3.948E-4 1.979E-3 2.534E-3 2 23
7 IPR013273 Peptidase M12B ADAM-TS InterPro 3.290E-5 3.948E-4 1.979E-3 2.763E-3 2 24
8 IPR002870 Peptidase M12B N InterPro 8.809E-5 5.457E-4 2.736E-3 7.399E-3 2 39
9 PF01562 Pep M12B propep Pfam 8.809E-5 5.457E-4 2.736E-3 7.399E-3 2 39
10 PF01421 Reprolysin Pfam 9.271E-5 5.457E-4 2.736E-3 7.788E-3 2 40
11 PS50215 ADAM MEPRO PROSITE 9.271E-5 5.457E-4 2.736E-3 7.788E-3 2 40
12 IPR001590 Peptidase M12B InterPro 9.271E-5 5.457E-4 2.736E-3 7.788E-3 2 40
13 PS50214 DISINTEGRIN 2 PROSITE 9.271E-5 5.457E-4 2.736E-3 7.788E-3 2 40
14 PS00427 DISINTEGRIN 1 PROSITE 9.271E-5 5.457E-4 2.736E-3 7.788E-3 2 40
15 IPR001762 Disintegrin dom InterPro 9.745E-5 5.457E-4 2.736E-3 8.185E-3 2 41
16 PF08204 V-set CD47 Pfam 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
17 PF04549 CD47 Pfam 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
18 IPR013270 CD47 Vset InterPro 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
19 IPR013147 CD47 TM InterPro 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
20 IPR006704 CD47 InterPro 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
21 IPR028499 Thrombospondin-1 InterPro 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
22 IPR013275 Pept M12B ADAM-TS2 InterPro 3.736E-4 1.338E-3 6.709E-3 3.139E-2 1 1
23 IPR024079 MetalloPept cat dom InterPro 3.823E-4 1.338E-3 6.709E-3 3.211E-2 2 81
24 3.40.390.10 - Gene3D 3.823E-4 1.338E-3 6.709E-3 3.211E-2 2 81
25 PS00142 ZINC PROTEASE PROSITE 5.591E-4 1.879E-3 9.420E-3 4.697E-2 2 98
26 IPR009465 Spondin N InterPro 7.471E-4 2.241E-3 1.124E-2
6.276E-2
 1 2
27 PS51020 SPONDIN PROSITE 7.471E-4 2.241E-3 1.124E-2
6.276E-2
 1 2
28 PF06468 Spond N Pfam 7.471E-4 2.241E-3 1.124E-2
6.276E-2
 1 2
29 PS51019 REELIN PROSITE 1.121E-3 3.036E-3 1.522E-2
9.413E-2
 1 3
30 IPR002861 Reeler dom InterPro 1.121E-3 3.036E-3 1.522E-2
9.413E-2
 1 3
31 PF02014 Reeler Pfam 1.121E-3 3.036E-3 1.522E-2
9.413E-2
 1 3
32 PF15913 Furin-like 2 Pfam 1.494E-3 3.647E-3 1.829E-2
1.255E-1
 1 4
33 IPR003367 Thrombospondin 3-like rpt InterPro 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
34 IPR008859 Thrombospondin C InterPro 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
35 PS51236 TSP CTER PROSITE 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
36 4.10.1080.10 - Gene3D 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
37 IPR017897 Thrombospondin 3 rpt InterPro 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
38 IPR033772 UPA InterPro 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
39 IPR028974 TSP type-3 rpt InterPro 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
40 PS51234 TSP3 PROSITE 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
41 PF02412 TSP 3 Pfam 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
42 PF05735 TSP C Pfam 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
43 PF17217 UPA Pfam 1.867E-3 3.647E-3 1.829E-2
1.568E-1
 1 5
44 SM00181 EGF SMART 3.183E-3 6.076E-3 3.047E-2
2.673E-1
 2 236
45 SM00218 ZU5 SMART 3.358E-3 6.269E-3 3.143E-2
2.821E-1
 1 9
46 PS51145 ZU5 PROSITE 3.731E-3 6.813E-3 3.416E-2
3.134E-1
 1 10
47 PF00791 ZU5 Pfam 4.476E-3 7.832E-3 3.927E-2
3.760E-1
 1 12
48 IPR000906 ZU5 dom InterPro 4.476E-3 7.832E-3 3.927E-2
3.760E-1
 1 12
49 SM00261 FU SMART 6.707E-3 1.105E-2
5.539E-2
5.634E-1
 1 18
50 IPR006212 Furin repeat InterPro 6.707E-3 1.105E-2
5.539E-2
5.634E-1
 1 18
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 47 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1383054 Defective B3GALTL causes Peters-plus syndrome (PpS) BioSystems: REACTOME 2.296E-9 6.716E-8 2.980E-7 1.079E-7 4 37
2 1268735 O-glycosylation of TSR domain-containing proteins BioSystems: REACTOME 2.858E-9 6.716E-8 2.980E-7 1.343E-7 4 39
3 1383049 Diseases associated with O-glycosylation of proteins BioSystems: REACTOME 1.687E-8 2.644E-7 1.173E-6 7.931E-7 4 60
4 1269010 Diseases of glycosylation BioSystems: REACTOME 7.311E-8 8.591E-7 3.813E-6 3.436E-6 4 86
5 1268734 O-linked glycosylation BioSystems: REACTOME 2.451E-7 2.304E-6 1.022E-5 1.152E-5 4 116
6 1270244 Extracellular matrix organization BioSystems: REACTOME 1.064E-5 8.333E-5 3.698E-4 5.000E-4 4 298
7 M3008 Genes encoding structural ECM glycoproteins MSigDB C2 BIOCARTA (v6.0) 1.284E-4 8.619E-4 3.825E-3 6.033E-3 3 196
8 M5884 Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans MSigDB C2 BIOCARTA (v6.0) 3.493E-4 2.052E-3 9.108E-3 1.642E-2 3 275
9 1270260 Integrin cell surface interactions BioSystems: REACTOME 6.065E-4 3.167E-3 1.406E-2 2.850E-2 2 68
10 83068 ECM-receptor interaction BioSystems: KEGG 8.808E-4 4.140E-3 1.837E-2 4.140E-2 2 82
11 1270316 Netrin mediated repulsion signals BioSystems: REACTOME 5.610E-3 2.397E-2
1.064E-1
2.637E-1
 1 10
12 1270267 Ligand-independent caspase activation via DCC BioSystems: REACTOME 6.170E-3 2.417E-2
1.072E-1
2.900E-1
 1 11
13 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 7.173E-3 2.447E-2
1.086E-1
3.371E-1
 2 238
14 1270241 Signal regulatory protein (SIRP) family interactions BioSystems: REACTOME 7.288E-3 2.447E-2
1.086E-1
3.425E-1
 1 13
15 1270255 Syndecan interactions BioSystems: REACTOME 1.175E-2 3.615E-2
1.604E-1
5.523E-1
 1 21
16 1269607 Regulation of FZD by ubiquitination BioSystems: REACTOME 1.231E-2 3.615E-2
1.604E-1
5.784E-1
 1 22
17 1270263 Caspase activation via extrinsic apoptotic signalling pathway BioSystems: REACTOME 1.564E-2 4.324E-2
1.919E-1
7.351E-1
 1 28
18 138064 Syndecan-4-mediated signaling events BioSystems: Pathway Interaction Database 1.730E-2 4.518E-2
2.005E-1
8.133E-1
 1 31
Show 13 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1276 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20637190 O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Pubmed 4.645E-13 5.927E-10 4.581E-9 5.927E-10 5 73
2 27742621 TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
3 8550562 Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
4 19284971 Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
5 24848268 CD47-independent effects mediated by the TSP-derived 4N1K peptide. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
6 25697354 Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
7 25001859 Elevated postinjury thrombospondin 1-CD47 triggering aids differentiation of patients' defective inflammatory CD1a+dendritic cells. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
8 24840925 Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
9 18285447 Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
10 20610415 Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
11 23499828 Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
12 19661269 Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
13 12643280 A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
14 12902472 Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
15 27349907 Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
16 21343308 Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
17 18675774 Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
18 16951312 Thrombospondin/CD47 interaction: a pathway to generate regulatory T cells from human CD4+ CD25- T cells in response to inflammation. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
19 21256215 Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
20 22014686 Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
21 21168495 CD47 knockout mice exhibit improved recovery from spinal cord injury. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
22 16835222 CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
23 17363705 Targeting CD47: NO limit on therapeutic potential. Pubmed 2.879E-8 1.597E-6 1.235E-5 3.674E-5 2 2
24 24148348 Thrombospondin-1/CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic hedgehog pathway suppression. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
25 29042481 The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
26 17916772 Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
27 17572512 Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
28 22215724 Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
29 20923780 Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
30 17442977 Interactions between CD47 and thrombospondin reduce inflammation. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
31 18787106 Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
32 23591719 Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
33 23087362 Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
34 18855618 CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
35 17293482 Increasing survival of ischemic tissue by targeting CD47. Pubmed 8.637E-8 3.149E-6 2.434E-5 1.102E-4 2 3
36 11980922 Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. Pubmed 1.727E-7 5.651E-6 4.368E-5 2.204E-4 2 4
37 15700281 Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions. Pubmed 1.727E-7 5.651E-6 4.368E-5 2.204E-4 2 4
38 10094461 ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats. Pubmed 1.727E-7 5.651E-6 4.368E-5 2.204E-4 2 4
39 10397731 Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation. Pubmed 1.727E-7 5.651E-6 4.368E-5 2.204E-4 2 4
40 11831030 [ADAMTS family--new extracellular matrix degrading enzyme]. Pubmed 2.879E-7 9.183E-6 7.097E-5 3.673E-4 2 5
41 28228282 Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Pubmed 4.318E-7 1.312E-5 1.014E-4 5.509E-4 2 6
42 9169439 Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. Pubmed 4.318E-7 1.312E-5 1.014E-4 5.509E-4 2 6
43 11167130 ADAMTS: a novel family of extracellular matrix proteases. Pubmed 1.295E-6 3.842E-5 2.970E-4 1.652E-3 2 10
44 25770910 Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics. Pubmed 1.899E-6 5.506E-5 4.256E-4 2.423E-3 2 12
45 10464288 ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. Pubmed 3.451E-6 9.785E-5 7.563E-4 4.403E-3 2 16
46 23658023 Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. Pubmed 3.512E-5 4.842E-4 3.742E-3 4.482E-2 2 50
47 22261194 Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Pubmed 5.773E-5 4.842E-4 3.742E-3
7.367E-2
 2 64
48 20551380 Proteomics characterization of extracellular space components in the human aorta. Pubmed 1.442E-4 4.842E-4 3.742E-3
1.839E-1
 2 101
49 26077800 CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Pubmed 1.833E-4 4.842E-4 3.742E-3
2.339E-1
 1 1
50 20844200 Thrombospondin-1 derived from APCs regulates their capacity for allosensitization. Pubmed 1.833E-4 4.842E-4 3.742E-3
2.339E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 139 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ADAMTS2 ADAMTS2 interactions 2.284E-5 3.175E-3 1.751E-2 3.175E-3 2 19
2 int:CD47 CD47 interactions 7.925E-5 3.887E-3 2.144E-2 1.102E-2 2 35
3 int:ADAMTS4 ADAMTS4 interactions 8.390E-5 3.887E-3 2.144E-2 1.166E-2 2 36
4 int:THBS1 THBS1 interactions 1.899E-4 6.600E-3 3.640E-2 2.640E-2 2 54
5 int:ITGAV ITGAV interactions 3.866E-4 1.075E-2
5.928E-2
5.374E-2
 2 77
6 int:SPON1 SPON1 interactions 7.907E-4 1.832E-2
1.010E-1
1.099E-1
 1 2
7 int:ITGB1 ITGB1 interactions 1.148E-3 2.060E-2
1.136E-1
1.595E-1
 2 133
8 int:TNFAIP6 TNFAIP6 interactions 1.186E-3 2.060E-2
1.136E-1
1.648E-1
 1 3
9 int:RSPO3 RSPO3 interactions 1.581E-3 2.197E-2
1.212E-1
2.197E-1
 1 4
10 int:SRPX2 SRPX2 interactions 1.581E-3 2.197E-2
1.212E-1
2.197E-1
 1 4
11 int:UNC5A UNC5A interactions 1.976E-3 2.497E-2
1.377E-1
2.746E-1
 1 5
12 int:RHAG RHAG interactions 2.765E-3 2.906E-2
1.603E-1
3.843E-1
 1 7
13 int:TM4SF18 TM4SF18 interactions 2.765E-3 2.906E-2
1.603E-1
3.843E-1
 1 7
14 int:NTN1 NTN1 interactions 3.160E-3 2.906E-2
1.603E-1
4.392E-1
 1 8
15 int:TNFRSF11B TNFRSF11B interactions 3.160E-3 2.906E-2
1.603E-1
4.392E-1
 1 8
16 int:DPY19L3 DPY19L3 interactions 3.554E-3 2.906E-2
1.603E-1
4.940E-1
 1 9
17 int:P2RY2 P2RY2 interactions 3.554E-3 2.906E-2
1.603E-1
4.940E-1
 1 9
18 int:ADAM2 ADAM2 interactions 4.342E-3 3.173E-2
1.750E-1
6.036E-1
 1 11
19 int:DPH6 DPH6 interactions 4.342E-3 3.173E-2
1.750E-1
6.036E-1
 1 11
20 int:CALCR CALCR interactions 4.736E-3 3.173E-2
1.750E-1
6.583E-1
 1 12
21 int:ZNRF3 ZNRF3 interactions 5.130E-3 3.173E-2
1.750E-1
7.131E-1
 1 13
22 int:ADAM30 ADAM30 interactions 5.130E-3 3.173E-2
1.750E-1
7.131E-1
 1 13
23 int:THBS2 THBS2 interactions 5.917E-3 3.173E-2
1.750E-1
8.225E-1
 1 15
24 int:LILRB4 LILRB4 interactions 6.311E-3 3.173E-2
1.750E-1
8.772E-1
 1 16
25 int:BCAN BCAN interactions 6.311E-3 3.173E-2
1.750E-1
8.772E-1
 1 16
26 int:JAG1 JAG1 interactions 6.704E-3 3.173E-2
1.750E-1
9.318E-1
 1 17
27 int:HRG HRG interactions 7.097E-3 3.173E-2
1.750E-1
9.865E-1
 1 18
28 int:ACAN ACAN interactions 7.097E-3 3.173E-2
1.750E-1
9.865E-1
 1 18
29 int:EPB42 EPB42 interactions 7.097E-3 3.173E-2
1.750E-1
9.865E-1
 1 18
30 int:COL7A1 COL7A1 interactions 7.883E-3 3.173E-2
1.750E-1
1.000E0
 1 20
31 int:TFPI TFPI interactions 7.883E-3 3.173E-2
1.750E-1
1.000E0
 1 20
32 int:MANBA MANBA interactions 7.883E-3 3.173E-2
1.750E-1
1.000E0
 1 20
33 int:IGFBP5 IGFBP5 interactions 8.276E-3 3.173E-2
1.750E-1
1.000E0
 1 21
34 int:MT2A MT2A interactions 8.668E-3 3.173E-2
1.750E-1
1.000E0
 1 22
35 int:CFH CFH interactions 8.668E-3 3.173E-2
1.750E-1
1.000E0
 1 22
36 int:RAD51B RAD51B interactions 9.061E-3 3.173E-2
1.750E-1
1.000E0
 1 23
37 int:SIRPA SIRPA interactions 9.061E-3 3.173E-2
1.750E-1
1.000E0
 1 23
38 int:COL3A1 COL3A1 interactions 9.061E-3 3.173E-2
1.750E-1
1.000E0
 1 23
39 int:TMEM128 TMEM128 interactions 9.845E-3 3.173E-2
1.750E-1
1.000E0
 1 25
40 int:CD36 CD36 interactions 9.845E-3 3.173E-2
1.750E-1
1.000E0
 1 25
41 int:DHFR DHFR interactions 9.845E-3 3.173E-2
1.750E-1
1.000E0
 1 25
42 int:LOXL2 LOXL2 interactions 1.024E-2 3.173E-2
1.750E-1
1.000E0
 1 26
43 int:SPARC SPARC interactions 1.024E-2 3.173E-2
1.750E-1
1.000E0
 1 26
44 int:RAD51C RAD51C interactions 1.063E-2 3.173E-2
1.750E-1
1.000E0
 1 27
45 int:LGALS9C LGALS9C interactions 1.102E-2 3.173E-2
1.750E-1
1.000E0
 1 28
46 int:CLEC12A CLEC12A interactions 1.102E-2 3.173E-2
1.750E-1
1.000E0
 1 28
47 int:LAMB3 LAMB3 interactions 1.102E-2 3.173E-2
1.750E-1
1.000E0
 1 28
48 int:SCARB2 SCARB2 interactions 1.141E-2 3.173E-2
1.750E-1
1.000E0
 1 29
49 int:BNIP3 BNIP3 interactions 1.141E-2 3.173E-2
1.750E-1
1.000E0
 1 29
50 int:COL5A1 COL5A1 interactions 1.141E-2 3.173E-2
1.750E-1
1.000E0
 1 29
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q13.1-q13.2 3q13.1-q13.2 3.462E-4 2.077E-3 5.089E-3 2.077E-3 1 2
2 15q15 15q15 2.076E-3 3.942E-3 9.657E-3 1.245E-2 1 12
3 1q21-q23 1q21-q23 2.421E-3 3.942E-3 9.657E-3 1.453E-2 1 14
4 11p15.2 11p15.2 2.939E-3 3.942E-3 9.657E-3 1.764E-2 1 17
5 6q22.33 6q22.33 3.285E-3 3.942E-3 9.657E-3 1.971E-2 1 19
6 5q35.2 5q35.2 5.699E-3 5.699E-3 1.396E-2 3.420E-2 1 33
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 74 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 50 ADAM metallopeptidases with thrombospondin type 1 motif genenames.org 1.031E-5 5.156E-5 1.177E-4 5.156E-5 2 19

13: Coexpression [Display Chart] 7 input genes in category / 920 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18044827-Table2 Human Breast Bergamaschi08 278genes GeneSigDB 6.176E-7 5.682E-4 4.206E-3 5.682E-4 4 270
2 15374961-TableS2 Human Brain Freije04 595genes GeneSigDB 5.797E-6 2.667E-3 1.974E-2 5.333E-3 4 474
3 19038878-SuppTable3 Human Leukemia Lenz08 385genes GeneSigDB 1.139E-4 2.177E-2
1.611E-1
1.047E-1
 3 349
4 M1541 Genes down-regulated in NIH 3T3 cells (fibroblasts) 24 h after inducing MyoD [GeneID=4654] differentiation program. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.242E-4 2.177E-2
1.611E-1
1.143E-1
 2 57
5 18332228-TableS5 Human StemCell Ng08 62genes GeneSigDB 1.287E-4 2.177E-2
1.611E-1
1.184E-1
 2 58
6 18435859-ShorterGeneList Mouse Breast Piechocki08 558genes GeneSigDB 1.420E-4 2.177E-2
1.611E-1
1.306E-1
 3 376
7 16100004-Table5 Human StemCell Skottman06 91genes GeneSigDB 1.823E-4 2.396E-2
1.774E-1
1.677E-1
 2 69
8 M2259 Partial list of genes up-regulated in the kidney of GLIS2 [GeneID=84662] knockout mice compared to the wild type. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.703E-4 2.896E-2
2.144E-1
2.487E-1
 2 84
9 M19130 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not down-regulated at the previous time point, 14 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.833E-4 2.896E-2
2.144E-1
2.607E-1
 2 86
10 17018861-TableS1 Human StemCell Ehrchen07 102genes GeneSigDB 3.984E-4 3.530E-2
2.613E-1
3.665E-1
 2 102
11 20599952-Table1 Human BoneMarrow Maisel10 105genes GeneSigDB 4.221E-4 3.530E-2
2.613E-1
3.883E-1
 2 105
12 M2568 Genes up-regulated in lung tissue upon LPS aspiration with mechanical ventilation (MV) compared to control (PBS aspiration without MV). MSigDB C2: CGP Curated Gene Sets (v6.0) 6.262E-4 3.878E-2
2.870E-1
5.761E-1
 2 128
13 M1896 Genes down-regulated in dendritic cells (12 days): control versus 25-hydroxyvitamin D3 [PubChem=1593]. MSigDB C7: Immunologic Signatures (v6.0) 6.262E-4 3.878E-2
2.870E-1
5.761E-1
 2 128
14 14749371-Table2 Human Viral Scott04 135genes GeneSigDB 6.758E-4 3.878E-2
2.870E-1
6.218E-1
 2 133
15 M2397 Genes up-regulated in liver tissue upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.962E-4 3.878E-2
2.870E-1
6.405E-1
 2 135
16 M1484 Genes up-regulated in pancreatic cells from mice with double knockout of E2F1 [GeneID=1869] and E2F2 [GeneID=1870] compared to wild type. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.697E-4 3.878E-2
2.870E-1
8.001E-1
 2 151
17 M7626 Genes up-regulated in CD8 T cells: naïve versus 1' memory. MSigDB C7: Immunologic Signatures (v6.0) 1.100E-3 3.878E-2
2.870E-1
1.000E0
 2 170
18 M17079 Up-regulated genes distinguishing between two subtypes of gastric cancer: advanced (AGC) and early (EGC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.165E-3 3.878E-2
2.870E-1
1.000E0
 2 175
19 M8544 Up-regualted genes from the set F (Fig. 5a): specific signature shared by cells expressing AF4-MLL [GeneID=4299;4297] alone and those expressing both AF4-MLL and MLL-AF4 fusion proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.301E-3 3.878E-2
2.870E-1
1.000E0
 2 185
20 M8132 Genes down-regulated in decidual macrophages with ITGAX [GeneID=3687] high versus low. MSigDB C7: Immunologic Signatures (v6.0) 1.371E-3 3.878E-2
2.870E-1
1.000E0
 2 190
21 M4961 Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells (mDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.443E-3 3.878E-2
2.870E-1
1.000E0
 2 195
22 M3317 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 Int thymocytes versus CD8 thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.878E-2
2.870E-1
1.000E0
 2 199
23 M7985 Genes down-regulated in wildtype bone marrow-derived macrophages treated with rosiglitazone [PubChem=77999]: control versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.878E-2
2.870E-1
1.000E0
 2 199
24 M8737 Genes up-regulated in STAT5 double knock-in T cells: control versus IL2 [GeneID=3558] stimulation for 6h. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.878E-2
2.870E-1
1.000E0
 2 199
25 M7659 Genes down-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes: non-stimulated versus tretinoin [PubChem=444795] and Pam2CSK4 (96h). MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.878E-2
2.870E-1
1.000E0
 2 199
26 M9933 Genes down-regulated in B lymphocytes with MAP3K7 [GeneID=6885] knockout: untreated versus anti IgM for 6h. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.878E-2
2.870E-1
1.000E0
 2 199
27 19726060-Figure4a Human pancreas Farrow09 5genes TDPSvsPanc-1Cells. GeneSigDB 1.512E-3 3.878E-2
2.870E-1
1.000E0
 1 5
28 M7646 Genes down-regulated in CD4 [GeneID=920] T cells under germ free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
29 M7755 Genes down-regulated in macrophages after M. bovis BCG infection: 24h versus 48h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
30 M3722 Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with poly(I:C) (TLR3 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
31 M8319 Genes down-regulated in NKT cells: naïve versus activated. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
32 M4122 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
33 M6619 Genes down-regulated in bone marrow-derived macrophages with IL6 [GeneID=3569] knockout and 45 min of stimulation by: LPS versus IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
34 M7333 Genes up-regulated in HMC-1 (mast leukemia) cells: Cl-IB-MECA [PubChem=3035850] versus T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
35 M6418 Genes up-regulated in monocytes (12h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
36 M7232 Genes down-regulated in T cells treated with IL21 [GeneID=59067]: 1h versus 6h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.878E-2
2.870E-1
1.000E0
 2 200
37 18667080-TableS8 Human StemCell Kocer08 236genes GeneSigDB 1.624E-3 3.932E-2
2.911E-1
1.000E0
 2 207
38 19795415-Table1 Mouse Lung Beisiegel09 262genes GeneSigDB 1.624E-3 3.932E-2
2.911E-1
1.000E0
 2 207
39 M2010 Genes with high-CpG-density promoters (HCP) bearing the bivalent histone H3 trimethylation mark at K4 and K27 (H3K4me3 and H3K27me3) in neural progenitor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.671E-3 3.942E-2
2.918E-1
1.000E0
 2 210
40 M14136 Genes down-regulated early in HMEC cells (mammary epithelium) during acinar development in vitro. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.814E-3 4.172E-2
3.088E-1
1.000E0
 1 6
41 18593982-DownregulatedGeneList Human Breast Nam08 7genes DownregulatedGeneList GeneSigDB 2.116E-3 4.748E-2
3.515E-1
1.000E0
 1 7
Show 36 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 1210 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/5 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/5 TCGA-Esophagus 2.116E-7 2.561E-4 1.966E-3 2.561E-4 4 195
2 gudmap kidney adult RenalCapsule 500 kidney adult RenalCapsule top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.105E-6 2.195E-3 1.685E-2 4.967E-3 4 410
3 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type C/4/1 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type C/4/1 TCGA-Thymus 5.441E-6 2.195E-3 1.685E-2 6.584E-3 3 119
4 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Nonmucinous Lepidic Adenocarcinoma/1/2 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Nonmucinous Lepidic Adenocarcinoma/1/2 TCGA-Lung 1.425E-5 3.071E-3 2.358E-2 1.725E-2 3 164
5 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/4/1 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/4/1 TCGA-Stomach 1.560E-5 3.071E-3 2.358E-2 1.887E-2 3 169
6 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 1000 K3 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 1.947E-5 3.071E-3 2.358E-2 2.356E-2 3 182
7 gudmap kidney P0 CapMes Crym k4 200 kidney P0 CapMes Crym k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.030E-5 3.071E-3 2.358E-2 2.456E-2 2 22
8 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6/3 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6/3 TCGA-Kidney 2.044E-5 3.071E-3 2.358E-2 2.474E-2 3 185
9 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Mature Teratoma, Yolk Sac Tumor/4 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Mature Teratoma, Yolk Sac Tumor/4 TCGA-Testes 2.285E-5 3.071E-3 2.358E-2 2.764E-2 3 192
10 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes 4.176E-5 4.242E-3 3.256E-2
5.053E-2
 3 235
11 gudmap kidney adult RenalCapsule k1 1000 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.352E-5 4.242E-3 3.256E-2
5.266E-2
 2 32
12 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 k3 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.352E-5 4.242E-3 3.256E-2
5.266E-2
 2 32
13 gudmap kidney adult RenalCapsule k1 500 kidney adult RenalCapsule k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.558E-5 4.242E-3 3.256E-2
5.515E-2
 3 242
14 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-C Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-C Lungmap CCHMC 6.314E-5 4.595E-3 3.527E-2
7.639E-2
 3 270
15 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal C Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal C Top 200 Genes 6.525E-5 4.595E-3 3.527E-2
7.895E-2
 3 273
16 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes 6.525E-5 4.595E-3 3.527E-2
7.895E-2
 3 273
17 Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-F Lungmap Mouse Lung PND1 MatrixFB Subtype MatrixFB-F Lungmap CCHMC 6.813E-5 4.595E-3 3.527E-2
8.244E-2
 3 277
18 gudmap kidney P0 CapMes Crym k1 500 kidney P0 CapMes Crym k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.836E-5 4.595E-3 3.527E-2
8.271E-2
 2 40
19 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Adenocarcinoma-NOS/5 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Adenocarcinoma-NOS/5 TCGA-Pancreas 8.285E-5 4.999E-3 3.837E-2
1.003E-1
 2 44
20 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 2500 K2 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 2500 k-means-cluster#2 FaceBase_RNAseq 8.806E-5 4.999E-3 3.837E-2
1.066E-1
 3 302
21 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D Top 200 Genes 9.517E-5 4.999E-3 3.837E-2
1.152E-1
 3 310
22 Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Fibroblast Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 9.517E-5 4.999E-3 3.837E-2
1.152E-1
 3 310
23 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-2 PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-2 PND01-03 Top 200 Genes 1.036E-4 4.999E-3 3.837E-2
1.254E-1
 3 319
24 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-2 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-2 Top 200 Genes 1.036E-4 4.999E-3 3.837E-2
1.254E-1
 3 319
25 BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Subtype Neuron.excitatory.Slc17a7.Parm1 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Subtype Neuron.excitatory.Slc17a7.Parm1 FrontalCortex Top 200 Genes BrainMap 1.105E-4 4.999E-3 3.837E-2
1.337E-1
 3 326
26 BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Top 200 BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Top 200 BrainMap 1.105E-4 4.999E-3 3.837E-2
1.337E-1
 3 326
27 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 1000 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.115E-4 4.999E-3 3.837E-2
1.350E-1
 2 51
28 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A E18.5 Top 200 Genes 1.387E-4 5.621E-3 4.315E-2
1.678E-1
 3 352
29 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-3 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-3 Top 200 Genes 1.470E-4 5.621E-3 4.315E-2
1.779E-1
 3 359
30 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D PND07-28 Top 200 Genes 1.544E-4 5.621E-3 4.315E-2
1.868E-1
 3 365
31 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal D Top 200 Genes 1.544E-4 5.621E-3 4.315E-2
1.868E-1
 3 365
32 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MatrixFB-A Top 200 Genes 1.569E-4 5.621E-3 4.315E-2
1.899E-1
 3 367
33 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype MyoFB-3 PND01-03 Top 200 Genes 1.594E-4 5.621E-3 4.315E-2
1.929E-1
 3 369
34 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgM Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgM Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.652E-4 5.621E-3 4.315E-2
1.998E-1
 2 62
35 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C PND07-28 Top 200 Genes 1.672E-4 5.621E-3 4.315E-2
2.023E-1
 3 375
36 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype mesenchymal C Top 200 Genes 1.672E-4 5.621E-3 4.315E-2
2.023E-1
 3 375
37 gudmap kidney P2 CapMes Crym k3 1000 kidney P2 CapMes Crym k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.872E-4 6.070E-3 4.660E-2
2.266E-1
 2 66
38 gudmap developingLowerUrinaryTract P1 ureter 500 DevelopingLowerUrinaryTract P1 ureter emap-30363 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.906E-4 6.070E-3 4.660E-2
2.307E-1
 3 392
39 gudmap developingKidney e15.5 anlage of loop of Henle 500 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.054E-4 6.371E-3 4.891E-2
2.485E-1
 3 402
40 gudmap kidney P1 CapMes Crym k3 1000 kidney P1 CapMes Crym k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.419E-4 7.317E-3
5.617E-2
2.927E-1
 2 75
41 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.488E-4 7.341E-3
5.635E-2
3.010E-1
 3 429
42 GSM777046 500 Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4 Immgen.org, GSE15907 2.645E-4 7.619E-3
5.848E-2
3.200E-1
 3 438
43 GSM777043 500 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 2.771E-4 7.760E-3
5.956E-2
3.353E-1
 3 445
44 gudmap developingLowerUrinaryTract P1 ureter 500 k3 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.822E-4 7.760E-3
5.956E-2
3.414E-1
 2 81
45 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 200 k2 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.892E-4 7.776E-3
5.969E-2
3.499E-1
 2 82
46 gudmap kidney P0 CapMes Crym k2 1000 kidney P0 CapMes Crym k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.107E-4 8.051E-3
6.180E-2
3.760E-1
 2 85
47 Lung Development Lungmap - Mouse FluidigmC1 Fibroblast Overall Top 500 Genes Lung Development Lungmap - Mouse FluidigmC1 Fibroblast Overall Top 500 Genes 3.134E-4 8.051E-3
6.180E-2
3.792E-1
 3 464
48 GSM777050 500 Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5 Immgen.org, GSE15907 3.194E-4 8.051E-3
6.180E-2
3.864E-1
 3 467
49 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k4 1000 DevelopingLowerUrinaryTract e14.5 bladder emap-6668 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.880E-4 9.582E-3
7.355E-2
4.695E-1
 2 95
50 GSM777043 100 Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3 Immgen.org, GSE15907 4.045E-4 9.789E-3
7.514E-2
4.894E-1
 2 97
Show 45 more annotations

15: Computational [Display Chart] 4 input genes in category / 26 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 378 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4708-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.005E-5 1.236E-2
8.050E-2
 3.026E-2 2 142
2 hsa-miR-1252-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.661E-5 1.236E-2
8.050E-2
 3.652E-2 2 156
3 hsa-miR-3149:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.188E-4 1.236E-2
8.050E-2
 4.491E-2 2 173
4 ATGCTGC,MIR-103:MSigDB ATGCTGC,MIR-103:MSigDB MSigDB 1.635E-4 1.236E-2
8.050E-2
6.180E-2
 2 203
5 ATGCTGC,MIR-107:MSigDB ATGCTGC,MIR-107:MSigDB MSigDB 1.635E-4 1.236E-2
8.050E-2
6.180E-2
 2 203
6 hsa-miR-297:PITA hsa-miR-297:PITA TOP PITA 2.171E-4 1.240E-2
8.075E-2
8.205E-2
 2 234
7 hsa-miR-1827:PITA hsa-miR-1827:PITA TOP PITA 2.698E-4 1.240E-2
8.075E-2
1.020E-1
 2 261
8 hsa-miR-194:PITA hsa-miR-194:PITA TOP PITA 2.908E-4 1.240E-2
8.075E-2
1.099E-1
 2 271
9 hsa-miR-940:PITA hsa-miR-940:PITA TOP PITA 3.059E-4 1.240E-2
8.075E-2
1.156E-1
 2 278
10 hsa-miR-606:PITA hsa-miR-606:PITA TOP PITA 3.584E-4 1.240E-2
8.075E-2
1.355E-1
 2 301
11 hsa-miR-5096:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.608E-4 1.240E-2
8.075E-2
1.364E-1
 2 302
12 hsa-miR-214:PITA hsa-miR-214:PITA TOP PITA 4.023E-4 1.267E-2
8.254E-2
1.521E-1
 2 319
13 hsa-miR-572:mirSVR lowEffct hsa-miR-572:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.920E-4 1.290E-2
8.401E-2
1.860E-1
 2 353
14 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 5.430E-4 1.290E-2
8.401E-2
2.053E-1
 2 371
15 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 5.430E-4 1.290E-2
8.401E-2
2.053E-1
 2 371
16 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 5.460E-4 1.290E-2
8.401E-2
2.064E-1
 2 372
17 hsa-miR-339-3p:mirSVR lowEffct hsa-miR-339-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.875E-4 1.306E-2
8.509E-2
2.221E-1
 2 386
18 hsa-miR-122*:mirSVR lowEffct hsa-miR-122*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.751E-4 1.418E-2
9.234E-2
2.552E-1
 2 414
19 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 8.211E-4 1.634E-2
1.064E-1
3.104E-1
 2 457
20 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 9.013E-4 1.703E-2
1.109E-1
3.407E-1
 2 479
21 hsa-miR-487b-3p:Functional MTI Functional MTI miRTarbase 1.936E-3 3.486E-2
2.270E-1
7.320E-1
 1 20
22 hsa-miR-4655-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.420E-3 3.695E-2
2.406E-1
9.148E-1
 1 25
23 hsa-miR-4637:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.420E-3 3.695E-2
2.406E-1
9.148E-1
 1 25
24 hsa-miR-4694-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 3.695E-2
2.406E-1
1.000E0
 1 35
25 hsa-miR-744:PITA hsa-miR-744:PITA TOP PITA 3.387E-3 3.695E-2
2.406E-1
1.000E0
 1 35
26 hsa-miR-625-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.773E-3 3.695E-2
2.406E-1
1.000E0
 1 39
27 hsa-miR-3144-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.695E-2
2.406E-1
1.000E0
 1 40
28 hsa-miR-875-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.256E-3 3.695E-2
2.406E-1
1.000E0
 1 44
29 TCTGATC,MIR-383:MSigDB TCTGATC,MIR-383:MSigDB MSigDB 4.546E-3 3.695E-2
2.406E-1
1.000E0
 1 47
30 hsa-miR-675-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 3.695E-2
2.406E-1
1.000E0
 1 56
31 hsa-miR-1255b-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.510E-3 3.695E-2
2.406E-1
1.000E0
 1 57
32 hsa-miR-5689:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.695E-2
2.406E-1
1.000E0
 1 58
33 hsa-miR-1179:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.703E-3 3.695E-2
2.406E-1
1.000E0
 1 59
34 hsa-miR-5003-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 3.695E-2
2.406E-1
1.000E0
 1 60
35 hsa-miR-3181:mirSVR highEffct hsa-miR-3181:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.992E-3 3.695E-2
2.406E-1
1.000E0
 1 62
36 hsa-miR-4450:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.282E-3 3.695E-2
2.406E-1
1.000E0
 1 65
37 hsa-miR-6733-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 3.695E-2
2.406E-1
1.000E0
 1 68
38 hsa-miR-296-5p:PITA hsa-miR-296-5p:PITA TOP PITA 6.667E-3 3.695E-2
2.406E-1
1.000E0
 1 69
39 hsa-miR-219a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 3.695E-2
2.406E-1
1.000E0
 1 69
40 GGGGCCC,MIR-296:MSigDB GGGGCCC,MIR-296:MSigDB MSigDB 6.667E-3 3.695E-2
2.406E-1
1.000E0
 1 69
41 hsa-miR-6126:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 3.695E-2
2.406E-1
1.000E0
 1 70
42 AAGGGAT,MIR-188:MSigDB AAGGGAT,MIR-188:MSigDB MSigDB 6.860E-3 3.695E-2
2.406E-1
1.000E0
 1 71
43 hsa-miR-411-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.052E-3 3.695E-2
2.406E-1
1.000E0
 1 73
44 hsa-miR-648:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.149E-3 3.695E-2
2.406E-1
1.000E0
 1 74
45 hsa-miR-198:Functional MTI Functional MTI miRTarbase 7.149E-3 3.695E-2
2.406E-1
1.000E0
 1 74
46 hsa-miR-571:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 3.695E-2
2.406E-1
1.000E0
 1 75
47 hsa-miR-106b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.341E-3 3.695E-2
2.406E-1
1.000E0
 1 76
48 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 3.695E-2
2.406E-1
1.000E0
 1 77
49 hsa-miR-380-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 3.695E-2
2.406E-1
1.000E0
 1 77
50 hsa-miR-1201:PITA hsa-miR-1201:PITA TOP PITA 7.438E-3 3.695E-2
2.406E-1
1.000E0
 1 77
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 2222 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000657027 AC1LCVWJ Stitch 8.758E-7 1.946E-3 1.612E-2 1.946E-3 3 68
2 CID000104802 Rgd Peptide Stitch 3.839E-5 3.263E-2
2.703E-1
8.530E-2
 3 239
3 CID000107475 Val-Val Stitch 5.933E-5 3.263E-2
2.703E-1
1.318E-1
 2 39
4 CID000492974 Grgesp Stitch 6.891E-5 3.263E-2
2.703E-1
1.531E-1
 2 42
5 CID006450551 axitinib Stitch 7.920E-5 3.263E-2
2.703E-1
1.760E-1
 2 45
6 CID000124822 copper histidinate Stitch 1.366E-4 3.263E-2
2.703E-1
3.035E-1
 2 59
7 ctd:D018818 Fenoldopam CTD 1.366E-4 3.263E-2
2.703E-1
3.035E-1
 2 59
8 CID000024766 chondroitin sulfate Stitch 1.946E-4 3.263E-2
2.703E-1
4.324E-1
 3 413
9 CID003002890 AC1MHEDL Stitch 2.391E-4 3.263E-2
2.703E-1
5.313E-1
 2 78
10 CID000123811 Grgds Stitch 2.707E-4 3.263E-2
2.703E-1
6.016E-1
 2 83
11 CID000090960 3,5,5-trimethylhexanoic acid Stitch 3.065E-4 3.263E-2
2.703E-1
6.810E-1
 1 1
12 CID000220840 isonicotinanilide Stitch 3.065E-4 3.263E-2
2.703E-1
6.810E-1
 1 1
13 CID000248078 7-hydroxy-1-indanone Stitch 3.065E-4 3.263E-2
2.703E-1
6.810E-1
 1 1
14 CID000128113 3,5,5-trimethylhexanoyloxybenzene sulfonate Stitch 3.065E-4 3.263E-2
2.703E-1
6.810E-1
 1 1
15 ctd:D006052 Gold Sodium Thiomalate CTD 3.326E-4 3.263E-2
2.703E-1
7.390E-1
 2 92
16 CID000108169 Taxane Stitch 4.167E-4 3.263E-2
2.703E-1
9.259E-1
 2 103
17 CID000107775 Rgds Peptide Stitch 4.413E-4 3.263E-2
2.703E-1
9.805E-1
 2 106
18 CID000115346 Gdrgdsp Stitch 4.665E-4 3.263E-2
2.703E-1
1.000E0
 2 109
19 CID000120739 G 3012 Stitch 6.830E-4 3.263E-2
2.703E-1
1.000E0
 2 132
20 CID000115098 trypanothione disulfide Stitch 7.677E-4 3.263E-2
2.703E-1
1.000E0
 2 140
21 CID000092105 1-MHis Stitch 9.192E-4 3.263E-2
2.703E-1
1.000E0
 1 3
22 CID000101180 Histidylalanine Stitch 9.192E-4 3.263E-2
2.703E-1
1.000E0
 1 3
23 CID011173518 salinosporamide B Stitch 1.225E-3 3.263E-2
2.703E-1
1.000E0
 1 4
24 CID000159485 2-iodo-7,8-dibromodibenzo-p-dioxin Stitch 1.225E-3 3.263E-2
2.703E-1
1.000E0
 1 4
25 2620 DN Amoxicillin [26787-78-0]; Down 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.334E-3 3.263E-2
2.703E-1
1.000E0
 2 185
26 2686 UP 17-AAG; Up 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.334E-3 3.263E-2
2.703E-1
1.000E0
 2 185
27 6955 DN ICI 182,780; Down 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.363E-3 3.263E-2
2.703E-1
1.000E0
 2 187
28 4323 DN Dicumarol [66-76-2]; Down 200; 11.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.363E-3 3.263E-2
2.703E-1
1.000E0
 2 187
29 1742 UP Scoulerine [6451-73-6]; Up 200; 12.2uM; HL60; HG-U133A Broad Institute CMAP Up 1.392E-3 3.263E-2
2.703E-1
1.000E0
 2 189
30 6997 DN ICI 182,780; Down 200; 0.01uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.392E-3 3.263E-2
2.703E-1
1.000E0
 2 189
31 6274 DN Rauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.406E-3 3.263E-2
2.703E-1
1.000E0
 2 190
32 2634 DN Guanfacine hydrochloride [29110-48-3]; Down 200; 14.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.421E-3 3.263E-2
2.703E-1
1.000E0
 2 191
33 1813 UP Triflupromazine hydrochloride [1098-60-8]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.421E-3 3.263E-2
2.703E-1
1.000E0
 2 191
34 4299 DN Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.421E-3 3.263E-2
2.703E-1
1.000E0
 2 191
35 2227 DN Terfenadine [50679-08-8]; Down 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.421E-3 3.263E-2
2.703E-1
1.000E0
 2 191
36 4018 DN Niclosamide [50-65-7]; Down 200; 12.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.436E-3 3.263E-2
2.703E-1
1.000E0
 2 192
37 970 DN 5230742; Down 200; 17uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.436E-3 3.263E-2
2.703E-1
1.000E0
 2 192
38 6728 UP Betamethasone [378-44-9]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.436E-3 3.263E-2
2.703E-1
1.000E0
 2 192
39 3221 DN Metergoline [17692-51-2]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 3.263E-2
2.703E-1
1.000E0
 2 193
40 6644 UP Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.465E-3 3.263E-2
2.703E-1
1.000E0
 2 194
41 7492 DN semustine; Down 200; 100uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.465E-3 3.263E-2
2.703E-1
1.000E0
 2 194
42 5075 DN Hydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.465E-3 3.263E-2
2.703E-1
1.000E0
 2 194
43 2886 DN Prenylamine lactate [69-43-2]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.465E-3 3.263E-2
2.703E-1
1.000E0
 2 194
44 5330 DN Rolipram [61413-54-5]; Down 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
45 1859 DN Sulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
46 3829 UP Mepenzolate bromide [76-90-4]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
47 4428 DN aspirin, USP; Down 200; 100uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
48 4267 UP Demeclocycline hydrochloride [64-73-3]; Up 200; 8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
49 1815 UP Sulindac [38194-50-2]; Up 200; 11.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
50 6415 UP Orlistat; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.263E-2
2.703E-1
1.000E0
 2 195
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 280 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C2700425 EHLERS-DANLOS SYNDROME, DERMATOSPARAXIS TYPE DisGeNET Curated 1.598E-6 4.476E-4 2.781E-3 4.476E-4 2 5
2 C0456107 Neonatal meningitis DisGeNET BeFree 3.355E-6 4.698E-4 2.919E-3 9.395E-4 2 7
3 C0013720 Ehlers-Danlos Syndrome DisGeNET Curated 2.099E-4 7.559E-3 4.697E-2
5.878E-2
 2 52
4 C0085096 Peripheral Vascular Diseases DisGeNET Curated 3.085E-4 7.559E-3 4.697E-2
8.637E-2
 2 63
5 C0751713 Inclusion Body Myopathy, Sporadic DisGeNET BeFree 3.184E-4 7.559E-3 4.697E-2
8.914E-2
 2 64
6 cv:C2700425 Dermatosparaxis Clinical Variations 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
7 C1857011 Recurrent mandibular subluxations DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
8 C3508775 EHLERS-DANLOS SYNDROME, TYPE VIIC DisGeNET BeFree 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
9 C0005742 Blepharochalasis DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
10 C1857013 Gingival hyperkeratosis DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
11 C1857012 Frontal open bite DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
12 OMIN:225410 EHLERS-DANLOS SYNDROME, TYPE VII, AUTOSOMAL RECESSIVE OMIM 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
13 C1849043 Soft, doughy skin DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
14 C4025059 Abnormality of primary molar morphology DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
15 C1857021 Neonatal pneumothorax DisGeNET Curated 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
16 C1281914 Corneal allograft rejection DisGeNET BeFree 4.320E-4 7.559E-3 4.697E-2
1.210E-1
 1 1
17 C0025289 Meningitis DisGeNET Curated 4.729E-4 7.788E-3 4.840E-2
1.324E-1
 2 78
18 C0022408 Arthropathy DisGeNET Curated 9.893E-4 1.539E-2
9.562E-2
2.770E-1
 2 113
19 C1260874 Infective dermatitis DisGeNET BeFree 1.295E-3 1.814E-2
1.127E-1
3.627E-1
 1 3
20 C4025283 Compensated hemolytic anemia DisGeNET Curated 1.295E-3 1.814E-2
1.127E-1
3.627E-1
 1 3
21 C1297883 Radial scar DisGeNET BeFree 1.727E-3 2.198E-2
1.366E-1
4.835E-1
 1 4
22 C0339578 Corticosteroid-induced glaucoma DisGeNET BeFree 1.727E-3 2.198E-2
1.366E-1
4.835E-1
 1 4
23 C0015944 Fetal Membranes, Premature Rupture DisGeNET Curated 2.158E-3 2.627E-2
1.633E-1
6.043E-1
 1 5
24 C0036329 Schistosomiasis japonica DisGeNET BeFree 2.589E-3 3.021E-2
1.877E-1
7.250E-1
 1 6
25 C2584778 Thrombotic thrombocytopenic purpura, acquired DisGeNET BeFree 3.020E-3 3.383E-2
2.102E-1
8.457E-1
 1 7
26 C1707758 Direct Contact Transmission Infection DisGeNET BeFree 3.451E-3 3.717E-2
2.309E-1
9.663E-1
 1 8
27 C1866423 Quebec platelet disorder DisGeNET Curated 3.882E-3 3.906E-2
2.427E-1
1.000E0
 1 9
28 C2745900 Promyelocytic leukemia DisGeNET BeFree 4.261E-3 3.906E-2
2.427E-1
1.000E0
 2 237
29 C1332965 Congenital Mesoblastic Nephroma DisGeNET Curated 4.312E-3 3.906E-2
2.427E-1
1.000E0
 1 10
30 C0022783 Vulvar Lichen Sclerosus DisGeNET Curated 4.312E-3 3.906E-2
2.427E-1
1.000E0
 1 10
31 C3840083 Late closure of anterior fontanel DisGeNET Curated 4.743E-3 3.906E-2
2.427E-1
1.000E0
 1 11
32 C4072831 Delayed closure of the soft spot on the skull DisGeNET Curated 4.743E-3 3.906E-2
2.427E-1
1.000E0
 1 11
33 C0585186 Cutaneous hypersensitivity DisGeNET BeFree 4.743E-3 3.906E-2
2.427E-1
1.000E0
 1 11
34 C1268935 Congenital Thrombotic Thrombocytopenic Purpura DisGeNET Curated 4.743E-3 3.906E-2
2.427E-1
1.000E0
 1 11
35 C0022573 Keratoconjunctivitis DisGeNET Curated 5.173E-3 3.922E-2
2.437E-1
1.000E0
 1 12
36 C0917804 Arteriovenous Malformations, Cerebral DisGeNET Curated 5.173E-3 3.922E-2
2.437E-1
1.000E0
 1 12
37 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 5.183E-3 3.922E-2
2.437E-1
1.000E0
 2 262
38 C0856761 Budd-Chiari Syndrome DisGeNET Curated 5.603E-3 4.120E-2
2.560E-1
1.000E0
 1 13
39 C3203102 Idiopathic pulmonary arterial hypertension DisGeNET Curated 5.818E-3 4.120E-2
2.560E-1
1.000E0
 2 278
40 C1096458 Vascular occlusion DisGeNET BeFree 6.033E-3 4.120E-2
2.560E-1
1.000E0
 1 14
41 C0019154 Hepatic Vein Thrombosis DisGeNET BeFree 6.033E-3 4.120E-2
2.560E-1
1.000E0
 1 14
42 C0747256 Parasitic infection DisGeNET BeFree 6.892E-3 4.322E-2
2.685E-1
1.000E0
 1 16
43 20090114:Benyamin Serum markers of iron status GWAS 6.892E-3 4.322E-2
2.685E-1
1.000E0
 1 16
44 C0037052 Sick Sinus Syndrome DisGeNET Curated 6.892E-3 4.322E-2
2.685E-1
1.000E0
 1 16
45 C0156259 Hypertrophy of kidney DisGeNET BeFree 7.322E-3 4.322E-2
2.685E-1
1.000E0
 1 17
46 C0011265 Presenile dementia DisGeNET BeFree 7.370E-3 4.322E-2
2.685E-1
1.000E0
 2 314
47 C0017565 Gingival Hemorrhage DisGeNET Curated 7.751E-3 4.322E-2
2.685E-1
1.000E0
 1 18
48 20090507:Lasky-Su Hyperactive-impulsive symptoms GWAS 7.751E-3 4.322E-2
2.685E-1
1.000E0
 1 18
49 C2826025 Mixed phenotype acute leukemia DisGeNET BeFree 7.751E-3 4.322E-2
2.685E-1
1.000E0
 1 18
50 C0241181 Fragile skin DisGeNET Curated 7.751E-3 4.322E-2
2.685E-1
1.000E0
 1 18
Show 45 more annotations