Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc352_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 66 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004022 alcohol dehydrogenase (NAD) activity 5.122E-26 3.381E-24 1.614E-23 3.381E-24 7 8
2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent 1.194E-22 3.942E-21 1.882E-20 7.883E-21 6 6
3 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.809E-16 8.380E-15 4.001E-14 2.514E-14 7 120
4 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1.552E-15 2.561E-14 1.223E-13 1.025E-13 7 146
5 GO:0004745 retinol dehydrogenase activity 2.117E-11 2.794E-10 1.334E-9 1.397E-9 4 18
6 GO:0035276 ethanol binding 1.293E-10 1.422E-9 6.789E-9 8.531E-9 3 4
7 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.911E-7 5.573E-6 2.661E-5 3.901E-5 3 49
8 GO:0051287 NAD binding 9.375E-7 7.735E-6 3.693E-5 6.188E-5 3 57
9 GO:0043178 alcohol binding 7.238E-6 5.308E-5 2.534E-4 4.777E-4 3 112
10 GO:0019841 retinol binding 9.390E-6 6.197E-5 2.959E-4 6.197E-4 2 13
11 GO:0050662 coenzyme binding 3.641E-5 2.184E-4 1.043E-3 2.403E-3 3 192
12 GO:0004032 alditol:NADP+ 1-oxidoreductase activity 4.873E-5 2.680E-4 1.280E-3 3.216E-3 2 29
13 GO:0008106 alcohol dehydrogenase (NADP+) activity 7.134E-5 3.622E-4 1.729E-3 4.709E-3 2 35
14 GO:0005501 retinoid binding 8.425E-5 3.813E-4 1.821E-3 5.560E-3 2 38
15 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 8.879E-5 3.813E-4 1.821E-3 5.860E-3 2 39
16 GO:0004033 aldo-keto reductase (NADP) activity 9.822E-5 3.813E-4 1.821E-3 6.482E-3 2 41
17 GO:0019840 isoprenoid binding 9.822E-5 3.813E-4 1.821E-3 6.482E-3 2 41
18 GO:0048037 cofactor binding 1.084E-4 3.973E-4 1.897E-3 7.151E-3 3 277
19 GO:0018467 formaldehyde dehydrogenase activity 3.751E-4 1.179E-3 5.629E-3 2.476E-2 1 1
20 GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity 3.751E-4 1.179E-3 5.629E-3 2.476E-2 1 1
21 GO:0005503 all-trans retinal binding 3.751E-4 1.179E-3 5.629E-3 2.476E-2 1 1
22 GO:0019842 vitamin binding 4.755E-4 1.427E-3 6.811E-3 3.138E-2 2 90
23 GO:0019115 benzaldehyde dehydrogenase activity 7.501E-4 2.063E-3 9.849E-3 4.951E-2 1 2
24 GO:0004031 aldehyde oxidase activity 7.501E-4 2.063E-3 9.849E-3 4.951E-2 1 2
25 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor 1.125E-3 2.970E-3 1.418E-2
7.425E-2
 1 3
26 GO:0003960 NADPH:quinone reductase activity 1.500E-3 3.807E-3 1.818E-2
9.898E-2
 1 4
27 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3.372E-3 8.242E-3 3.935E-2
2.225E-1
 1 9
28 GO:0048019 receptor antagonist activity 3.746E-3 8.829E-3 4.215E-2
2.472E-1
 1 10
29 GO:0016918 retinal binding 5.241E-3 1.153E-2
5.505E-2
3.459E-1
 1 14
30 GO:0030547 receptor inhibitor activity 5.241E-3 1.153E-2
5.505E-2
3.459E-1
 1 14
31 GO:0004029 aldehyde dehydrogenase (NAD) activity 7.107E-3 1.158E-2
5.529E-2
4.690E-1
 1 19
32 GO:0044105 L-xylulose reductase (NAD+) activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
33 GO:0044103 L-arabinose 1-dehydrogenase (NADP+) activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
34 GO:0018452 5-exo-hydroxycamphor dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
35 GO:0052677 D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
36 GO:0018453 2-hydroxytetrahydrofuran dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
37 GO:0008875 gluconate dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
38 GO:0019152 acetoin dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
39 GO:0033709 D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
40 GO:0034831 (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
41 GO:0004495 mevaldate reductase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
42 GO:0032867 L-arabinose:NADP reductase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
43 GO:0034840 3-hydroxymenthone dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
44 GO:0035380 very long-chain-3-hydroxyacyl-CoA dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
45 GO:0043713 (R)-2-hydroxyisocaproate dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
46 GO:0032442 phenylcoumaran benzylic ether reductase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
47 GO:0018451 epoxide dehydrogenase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
48 GO:0048258 3-ketoglucose-reductase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
49 GO:0032866 D-xylose:NADP reductase activity 8.597E-3 1.158E-2
5.529E-2
5.674E-1
 1 23
50 GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity 8.970E-3 1.161E-2
5.542E-2
5.920E-1
 1 24
Show 45 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 54 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006069 ethanol oxidation 5.144E-24 2.778E-22 1.271E-21 2.778E-22 7 12
2 GO:0006067 ethanol metabolic process 2.229E-23 6.018E-22 2.754E-21 1.204E-21 7 14
3 GO:0034308 primary alcohol metabolic process 5.579E-19 1.004E-17 4.595E-17 3.013E-17 7 49
4 GO:0006066 alcohol metabolic process 2.303E-12 3.109E-11 1.423E-10 1.244E-10 7 408
5 GO:0006068 ethanol catabolic process 1.137E-9 1.228E-8 5.621E-8 6.142E-8 3 7
6 GO:0034310 primary alcohol catabolic process 3.898E-9 3.508E-8 1.605E-7 2.105E-7 3 10
7 GO:0046164 alcohol catabolic process 5.311E-9 4.097E-8 1.875E-7 2.868E-7 4 67
8 GO:1901616 organic hydroxy compound catabolic process 1.210E-8 8.165E-8 3.736E-7 6.532E-7 4 82
9 GO:0001523 retinoid metabolic process 2.016E-8 1.210E-7 5.535E-7 1.089E-6 4 93
10 GO:0016101 diterpenoid metabolic process 2.706E-8 1.461E-7 6.685E-7 1.461E-6 4 100
11 GO:0006721 terpenoid metabolic process 4.126E-8 2.026E-7 9.268E-7 2.228E-6 4 111
12 GO:0006720 isoprenoid metabolic process 8.821E-8 3.969E-7 1.816E-6 4.763E-6 4 134
13 GO:0042572 retinol metabolic process 1.605E-7 6.669E-7 3.051E-6 8.669E-6 3 32
14 GO:0044282 small molecule catabolic process 5.118E-6 1.974E-5 9.033E-5 2.764E-4 4 370
15 GO:0006081 cellular aldehyde metabolic process 5.495E-6 1.978E-5 9.051E-5 2.967E-4 3 102
16 GO:0034754 cellular hormone metabolic process 8.739E-6 2.949E-5 1.350E-4 4.719E-4 3 119
17 GO:0045471 response to ethanol 1.682E-5 5.342E-5 2.444E-4 9.081E-4 3 148
18 GO:0042573 retinoic acid metabolic process 3.618E-5 1.085E-4 4.967E-4 1.954E-3 2 25
19 GO:0042445 hormone metabolic process 4.650E-5 1.322E-4 6.047E-4 2.511E-3 3 208
20 GO:0097305 response to alcohol 3.181E-4 8.588E-4 3.929E-3 1.718E-2 3 398
21 GO:0046186 acetaldehyde biosynthetic process 3.759E-4 9.665E-4 4.422E-3 2.030E-2 1 1
22 GO:0046294 formaldehyde catabolic process 7.516E-4 1.691E-3 7.738E-3 4.059E-2 1 2
23 GO:0010430 fatty acid omega-oxidation 7.516E-4 1.691E-3 7.738E-3 4.059E-2 1 2
24 GO:0006117 acetaldehyde metabolic process 7.516E-4 1.691E-3 7.738E-3 4.059E-2 1 2
25 GO:0046292 formaldehyde metabolic process 1.503E-3 3.246E-3 1.485E-2
8.115E-2
 1 4
26 GO:0051409 response to nitrosative stress 3.004E-3 6.238E-3 2.854E-2
1.622E-1
 1 8
27 GO:0018119 peptidyl-cysteine S-nitrosylation 4.128E-3 8.105E-3 3.708E-2
2.229E-1
 1 11
28 GO:0048149 behavioral response to ethanol 4.503E-3 8.105E-3 3.708E-2
2.431E-1
 1 12
29 GO:0051775 response to redox state 4.503E-3 8.105E-3 3.708E-2
2.431E-1
 1 12
30 GO:0017014 protein nitrosylation 4.503E-3 8.105E-3 3.708E-2
2.431E-1
 1 12
31 GO:0046185 aldehyde catabolic process 5.625E-3 9.205E-3 4.212E-2
3.038E-1
 1 15
32 GO:1900115 extracellular regulation of signal transduction 5.625E-3 9.205E-3 4.212E-2
3.038E-1
 1 15
33 GO:1900116 extracellular negative regulation of signal transduction 5.625E-3 9.205E-3 4.212E-2
3.038E-1
 1 15
34 GO:0046184 aldehyde biosynthetic process 6.373E-3 1.012E-2 4.632E-2
3.442E-1
 1 17
35 GO:0018198 peptidyl-cysteine modification 9.361E-3 1.444E-2
6.608E-2
5.055E-1
 1 25
36 GO:1901661 quinone metabolic process 1.085E-2 1.628E-2
7.448E-2
5.860E-1
 1 29
37 GO:0003016 respiratory system process 1.197E-2 1.747E-2
7.992E-2
6.463E-1
 1 32
38 GO:0017144 drug metabolic process 1.494E-2 2.123E-2
9.715E-2
8.068E-1
 1 40
39 GO:0033574 response to testosterone 1.605E-2 2.223E-2
1.017E-1
8.669E-1
 1 43
40 GO:0045777 positive regulation of blood pressure 1.865E-2 2.517E-2
1.152E-1
1.000E0
 1 50
41 GO:0007585 respiratory gaseous exchange 2.565E-2 3.379E-2
1.546E-1
1.000E0
 1 69
42 GO:0019395 fatty acid oxidation 3.663E-2 4.691E-2
2.147E-1
1.000E0
 1 99
43 GO:0034440 lipid oxidation 3.736E-2 4.691E-2
2.147E-1
1.000E0
 1 101
Show 38 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 0 annotations before applied cutoff / 19061 genes in category

No results to display

4: Human Phenotype [Display Chart] 2 input genes in category / 45 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0030858 Addictive behavior 9.029E-7 2.031E-5 8.928E-5 4.063E-5 2 5
2 HP:0030955 Alcoholism 9.029E-7 2.031E-5 8.928E-5 4.063E-5 2 5

5: Mouse Phenotype [Display Chart] 3 input genes in category / 42 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005444 abnormal retinol metabolism 5.595E-7 2.350E-5 1.017E-4 2.350E-5 2 5
2 MP:0011233 abnormal vitamin A metabolism 4.362E-6 4.580E-5 1.982E-4 1.832E-4 2 13
3 MP:0013244 abnormal vitamin metabolism 4.362E-6 4.580E-5 1.982E-4 1.832E-4 2 13
4 MP:0013274 abnormal vitamin or vitamin cofactor metabolism 4.362E-6 4.580E-5 1.982E-4 1.832E-4 2 13
5 MP:0009763 increased sensitivity to induced morbidity/mortality 3.764E-5 3.162E-4 1.368E-3 1.581E-3 3 348
6 MP:0020148 abnormal sensitivity to induced morbidity/mortality 8.884E-5 6.219E-4 2.691E-3 3.731E-3 3 463
7 MP:0005443 abnormal ethanol metabolism 5.794E-4 3.476E-3 1.504E-2 2.433E-2 1 2
8 MP:0011232 abnormal vitamin A level 4.629E-3 2.407E-2
1.042E-1
1.944E-1
 1 16
9 MP:0001263 weight loss 5.159E-3 2.407E-2
1.042E-1
2.167E-1
 2 436
10 MP:0000836 abnormal substantia nigra morphology 8.091E-3 3.089E-2
1.337E-1
3.398E-1
 1 28
11 MP:0008544 impaired olfaction 8.091E-3 3.089E-2
1.337E-1
3.398E-1
 1 28
12 MP:0001906 increased dopamine level 1.183E-2 4.101E-2
1.775E-1
4.970E-1
 1 41
13 MP:0005401 abnormal fat-soluble vitamin level 1.269E-2 4.101E-2
1.775E-1
5.332E-1
 1 44
14 MP:0001984 abnormal olfaction 1.499E-2 4.497E-2
1.946E-1
6.296E-1
 1 52
15 MP:0001983 abnormal olfactory system physiology 1.728E-2 4.612E-2
1.996E-1
7.259E-1
 1 60
16 MP:0005400 abnormal vitamin level 1.757E-2 4.612E-2
1.996E-1
7.380E-1
 1 61
17 MP:0004019 abnormal vitamin homeostasis 1.900E-2 4.694E-2
2.031E-1
7.981E-1
 1 66
Show 12 more annotations

6: Domain [Display Chart] 7 input genes in category / 15 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00059 ADH ZINC PROSITE 4.982E-26 3.737E-25 1.240E-24 7.473E-25 7 8
2 IPR002328 ADH Zn CS InterPro 4.982E-26 3.737E-25 1.240E-24 7.473E-25 7 8
3 PF08240 ADH N Pfam 7.125E-23 2.672E-22 8.866E-22 1.069E-21 7 16
4 IPR013154 ADH N InterPro 7.125E-23 2.672E-22 8.866E-22 1.069E-21 7 16
5 3.90.180.10 - Gene3D 1.982E-22 5.884E-22 1.952E-21 2.973E-21 7 18
6 IPR002085 ADH SF Zn-type InterPro 3.138E-22 5.884E-22 1.952E-21 4.707E-21 7 19
7 IPR013149 ADH C InterPro 3.138E-22 5.884E-22 1.952E-21 4.707E-21 7 19
8 PF00107 ADH zinc N Pfam 3.138E-22 5.884E-22 1.952E-21 4.707E-21 7 19
9 IPR011032 GroES-like InterPro 2.156E-21 3.593E-21 1.192E-20 3.233E-20 7 24
10 3.40.50.720 - Gene3D 4.290E-15 5.848E-15 1.940E-14 6.435E-14 7 169
11 IPR020843 PKS ER InterPro 4.767E-15 5.848E-15 1.940E-14 7.150E-14 5 16
12 SM00829 PKS ER SMART 4.767E-15 5.848E-15 1.940E-14 7.150E-14 5 16
13 IPR016040 NAD(P)-bd dom InterPro 5.068E-15 5.848E-15 1.940E-14 7.602E-14 7 173
14 IPR028632 Zinc ADH II InterPro 3.736E-4 3.736E-4 1.240E-3 5.604E-3 1 1
15 IPR014183 ADH 3 InterPro 3.736E-4 3.736E-4 1.240E-3 5.604E-3 1 1
Show 10 more annotations

7: Pathway [Display Chart] 7 input genes in category / 38 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270206 Ethanol oxidation BioSystems: REACTOME 8.624E-23 3.277E-21 1.386E-20 3.277E-21 7 12
2 MAP00120 Bile acid biosynthesis MAP00120 Bile acid biosynthesis GenMAPP 2.669E-20 5.072E-19 2.144E-18 1.014E-18 7 23
3 MAP00350 Tyrosine metabolism MAP00350 Tyrosine metabolism GenMAPP 2.217E-19 2.808E-18 1.187E-17 8.424E-18 7 30
4 82959 Tyrosine metabolism BioSystems: KEGG 7.322E-19 6.956E-18 2.941E-17 2.782E-17 7 35
5 82935 Fatty acid degradation BioSystems: KEGG 4.173E-18 3.171E-17 1.341E-16 1.586E-16 7 44
6 MAP00071 Fatty acid metabolism MAP00071 Fatty acid metabolism GenMAPP 5.828E-18 3.691E-17 1.561E-16 2.215E-16 7 46
7 MAP00561 Glycerolipid metabolism MAP00561 Glycerolipid metabolism GenMAPP 6.848E-18 3.718E-17 1.572E-16 2.602E-16 7 47
8 MAP00010 Glycolysis Gluconeogenesis MAP00010 Glycolysis Gluconeogenesis GenMAPP 1.457E-17 6.920E-17 2.926E-16 5.536E-16 7 52
9 83020 Retinol metabolism BioSystems: KEGG 7.581E-17 3.201E-16 1.353E-15 2.881E-15 7 65
10 82926 Glycolysis / Gluconeogenesis BioSystems: KEGG 9.469E-17 3.598E-16 1.521E-15 3.598E-15 7 67
11 83032 Drug metabolism - cytochrome P450 BioSystems: KEGG 1.305E-16 4.509E-16 1.906E-15 4.960E-15 7 70
12 83031 Metabolism of xenobiotics by cytochrome P450 BioSystems: KEGG 1.960E-16 6.205E-16 2.623E-15 7.446E-15 7 74
13 673221 Chemical carcinogenesis BioSystems: KEGG 4.140E-16 1.210E-15 5.116E-15 1.573E-14 7 82
14 1270190 Phase 1 - Functionalization of compounds BioSystems: REACTOME 3.698E-15 1.004E-14 4.244E-14 1.405E-13 7 111
15 1270189 Biological oxidations BioSystems: REACTOME 6.504E-13 1.648E-12 6.966E-12 2.472E-11 7 229
16 545354 noradrenaline and adrenaline degradation BioSystems: BIOCYC 9.130E-9 2.168E-8 9.168E-8 3.469E-7 3 9
17 1269631 RA biosynthesis pathway BioSystems: REACTOME 1.918E-7 4.288E-7 1.813E-6 7.290E-6 3 23
18 1269630 Signaling by Retinoic Acid BioSystems: REACTOME 1.330E-6 2.809E-6 1.187E-5 5.055E-5 3 43
19 545353 serotonin degradation BioSystems: BIOCYC 4.060E-6 8.121E-6 3.433E-5 1.543E-4 2 6
20 835392 superpathway of tryptophan utilization BioSystems: BIOCYC 1.333E-4 2.533E-4 1.071E-3 5.067E-3 2 32
21 545343 formaldehyde oxidation BioSystems: BIOCYC 1.124E-3 2.034E-3 8.601E-3 4.272E-2 1 2
22 142309 ethanol degradation II BioSystems: BIOCYC 2.247E-3 3.882E-3 1.641E-2
8.540E-2
 1 4
23 1270228 Abacavir metabolism BioSystems: REACTOME 2.809E-3 4.640E-3 1.962E-2
1.067E-1
 1 5
24 MAP00680 Methane metabolism MAP00680 Methane metabolism GenMAPP 3.930E-3 6.223E-3 2.631E-2
1.493E-1
 1 7
25 545352 acetone degradation I (to methylglyoxal) BioSystems: BIOCYC 4.490E-3 6.825E-3 2.886E-2
1.706E-1
 1 8
26 1270226 Abacavir transport and metabolism BioSystems: REACTOME 5.610E-3 8.200E-3 3.467E-2
2.132E-1
 1 10
27 PW:0000039 bile acid biosynthetic Pathway Ontology 7.288E-3 1.026E-2 4.337E-2
2.769E-1
 1 13
28 PW:0000052 tyrosine metabolic Pathway Ontology 8.964E-3 1.216E-2
5.143E-2
3.406E-1
 1 16
29 MAP00150 Androgen and estrogen metabolism MAP00150 Androgen and estrogen metabolism GenMAPP 9.521E-3 1.236E-2
5.224E-2
3.618E-1
 1 17
30 SMP00074 Retinol Metabolism SMPDB 1.008E-2 1.236E-2
5.224E-2
3.830E-1
 1 18
31 MAP00860 Porphyrin and chlorophyll metabolism MAP00860 Porphyrin and chlorophyll metabolism GenMAPP 1.008E-2 1.236E-2
5.224E-2
3.830E-1
 1 18
32 MAP00500 Starch and sucrose metabolism MAP00500 Starch and sucrose metabolism GenMAPP 1.231E-2 1.461E-2
6.179E-2
4.677E-1
 1 22
33 PW:0000058 fatty acid metabolic Pathway Ontology 1.286E-2 1.481E-2
6.263E-2
4.888E-1
 1 23
34 SMP00006 Tyrosine Metabolism SMPDB 1.342E-2 1.500E-2
6.341E-2
5.099E-1
 1 24
35 PW:0000025 glycolysis/gluconeogenesis Pathway Ontology 1.620E-2 1.758E-2
7.434E-2
6.154E-1
 1 29
36 PW:0000153 glycerolipid metabolic Pathway Ontology 1.675E-2 1.768E-2
7.475E-2
6.365E-1
 1 30
37 MAP00620 Pyruvate metabolism MAP00620 Pyruvate metabolism GenMAPP 1.730E-2 1.777E-2
7.514E-2
6.576E-1
 1 31
Show 32 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 723 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23468174 Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Pubmed 4.254E-29 1.538E-26 1.101E-25 3.076E-26 7 7
2 23456092 Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Pubmed 4.254E-29 1.538E-26 1.101E-25 3.076E-26 7 7
3 9982 Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Pubmed 1.624E-24 2.936E-22 2.103E-21 1.174E-21 6 6
4 17185388 Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. Pubmed 1.624E-24 2.936E-22 2.103E-21 1.174E-21 6 6
5 16685648 Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Pubmed 1.137E-23 1.644E-21 1.177E-20 8.221E-21 6 7
6 18331377 Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Pubmed 4.548E-23 5.481E-21 3.925E-20 3.288E-20 6 8
7 19193628 ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. Pubmed 3.102E-20 3.204E-18 2.294E-17 2.243E-17 5 5
8 19874574 Genetical genomic determinants of alcohol consumption in rats and humans. Pubmed 4.494E-18 4.061E-16 2.908E-15 3.249E-15 7 130
9 11784316 Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes. Pubmed 3.948E-16 2.595E-14 1.858E-13 2.855E-13 4 4
10 19687126 A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women. Pubmed 3.948E-16 2.595E-14 1.858E-13 2.855E-13 4 4
11 12027900 Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3. Pubmed 3.948E-16 2.595E-14 1.858E-13 2.855E-13 4 4
12 18996923 Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Pubmed 1.974E-15 1.098E-13 7.862E-13 1.427E-12 4 5
13 19861527 Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. Pubmed 1.974E-15 1.098E-13 7.862E-13 1.427E-12 4 5
14 19343046 Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Pubmed 1.074E-13 5.544E-12 3.970E-11 7.761E-11 6 193
15 19898482 Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Pubmed 2.765E-13 1.333E-11 9.543E-11 1.999E-10 5 66
16 8621625 Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
17 24722735 Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
18 10424757 Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
19 2347582 The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
20 3006456 Genetics of human alcohol and aldehyde dehydrogenases. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
21 22079585 Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
22 2737681 Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
23 14745297 Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
24 16121213 Merging protein, gene and genomic data: the evolution of the MDR-ADH family. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
25 11836246 Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
26 2935875 Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
27 8892527 Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
28 7738026 Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
29 10358022 Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. Pubmed 3.770E-12 9.398E-11 6.730E-10 2.725E-9 3 3
30 17270348 Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. Pubmed 1.080E-11 2.603E-10 1.864E-9 7.810E-9 4 30
31 16047160 Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh 1 mRNAs in rodent embryos. Pubmed 1.508E-11 3.303E-10 2.366E-9 1.090E-8 3 4
32 518534 Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Pubmed 1.508E-11 3.303E-10 2.366E-9 1.090E-8 3 4
33 17257171 High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease. Pubmed 1.508E-11 3.303E-10 2.366E-9 1.090E-8 3 4
34 20700531 The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population. Pubmed 3.769E-11 8.015E-10 5.740E-9 2.725E-8 3 5
35 19618839 Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. Pubmed 7.538E-11 1.514E-9 1.084E-8 5.450E-8 3 6
36 2169444 Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box. Pubmed 7.538E-11 1.514E-9 1.084E-8 5.450E-8 3 6
37 11747070 Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Pubmed 1.319E-10 2.577E-9 1.846E-8 9.536E-8 3 7
38 21437268 A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. Pubmed 2.110E-10 4.015E-9 2.875E-8 1.526E-7 3 8
39 12128098 Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos. Pubmed 4.521E-10 8.381E-9 6.002E-8 3.269E-7 3 10
40 20634891 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Pubmed 9.821E-10 1.775E-8 1.271E-7 7.101E-7 5 331
41 1896463 Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
42 20357489 Immunoglobulin E sensitization to cross-reactive carbohydrate determinants: epidemiological study of clinical relevance and role of alcohol consumption. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
43 9241435 Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
44 17295732 Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
45 20494945 Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
46 20031627 Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypes. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
47 2893758 Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
48 18761854 [Genetic variations in alcohol dehydrogenase, drinking habits and alcoholism]. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
49 16117582 Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
50 11274460 Three-dimensional structures of the three human class I alcohol dehydrogenases. Pubmed 2.879E-8 2.169E-7 1.553E-6 2.082E-5 2 2
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 40 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ADH1C ADH1C interactions 8.038E-7 3.215E-5 1.376E-4 3.215E-5 2 4
2 int:ADH1B ADH1B interactions 3.748E-6 7.497E-5 3.208E-4 1.499E-4 2 8
3 int:PQLC1 PQLC1 interactions 1.186E-3 9.033E-3 3.865E-2 4.743E-2 1 3
4 int:ADH1A ADH1A interactions 1.186E-3 9.033E-3 3.865E-2 4.743E-2 1 3
5 int:ADH7 ADH7 interactions 1.186E-3 9.033E-3 3.865E-2 4.743E-2 1 3
6 int:ADH4 ADH4 interactions 1.581E-3 9.033E-3 3.865E-2
6.323E-2
 1 4
7 int:XYLT1 XYLT1 interactions 1.581E-3 9.033E-3 3.865E-2
6.323E-2
 1 4
8 int:ADH6 ADH6 interactions 3.554E-3 1.777E-2
7.603E-2
1.422E-1
 1 9
9 int:RPAIN RPAIN interactions 4.342E-3 1.930E-2
8.257E-2
1.737E-1
 1 11
10 int:PTGR1 PTGR1 interactions 5.917E-3 2.367E-2
1.013E-1
2.367E-1
 1 15
11 int:IRAK3 IRAK3 interactions 8.276E-3 2.759E-2
1.180E-1
3.310E-1
 1 21
12 int:ADH5 ADH5 interactions 8.276E-3 2.759E-2
1.180E-1
3.310E-1
 1 21
13 int:ALDH4A1 ALDH4A1 interactions 9.061E-3 2.788E-2
1.193E-1
3.624E-1
 1 23
14 int:HADH HADH interactions 1.102E-2 3.149E-2
1.347E-1
4.408E-1
 1 28
15 int:ESD ESD interactions 1.259E-2 3.357E-2
1.436E-1
5.035E-1
 1 32
16 int:ESRRA ESRRA interactions 1.571E-2 3.718E-2
1.591E-1
6.285E-1
 1 40
17 int:PTPN4 PTPN4 interactions 1.610E-2 3.718E-2
1.591E-1
6.441E-1
 1 41
18 int:SERPINA3 SERPINA3 interactions 1.688E-2 3.718E-2
1.591E-1
6.753E-1
 1 43
19 int:RASSF5 RASSF5 interactions 1.766E-2 3.718E-2
1.591E-1
7.065E-1
 1 45
20 int:ANKRD17 ANKRD17 interactions 2.000E-2 3.999E-2
1.711E-1
7.998E-1
 1 51
Show 15 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 3 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q23 4q23 1.326E-15 3.977E-15 7.292E-15 3.977E-15 5 22
2 4q23-q24 4q23-q24 2.020E-4 3.029E-4 5.554E-4 6.059E-4 1 1
3 4q22 4q22 1.816E-3 1.816E-3 3.330E-3 5.449E-3 1 9

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 2 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 397 Alcohol dehydrogenases genenames.org 6.117E-26 6.117E-26 6.117E-26 6.117E-26 7 8

13: Coexpression [Display Chart] 7 input genes in category / 441 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19010862-TableS2 Human Breast Laere08 205genes GeneSigDB 2.915E-15 1.286E-12 8.572E-12 1.286E-12 7 197
2 15958054-Table3 Human Stomach Yanagihara05 60genes GeneSigDB 1.105E-7 1.701E-5 1.134E-4 4.874E-5 3 35
3 18221535-Table2 Human Liver Parent08 55genes GeneSigDB 1.312E-7 1.701E-5 1.134E-4 5.785E-5 3 37
4 M3649 Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 2 h time point that were not up-regulated at the previous time point, 1 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.542E-7 1.701E-5 1.134E-4 6.802E-5 3 39
5 M12176 Genes down-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.260E-7 1.993E-5 1.329E-4 9.965E-5 4 210
6 M9911 Genes negatively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.379E-6 1.014E-4 6.760E-4 6.083E-4 3 80
7 M19130 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 16 h time point that were not down-regulated at the previous time point, 14 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.717E-6 1.082E-4 7.211E-4 7.571E-4 3 86
8 17161497-SuppTable1 Human Lung Dracheva07 162genes GeneSigDB 8.457E-6 4.662E-4 3.108E-3 3.730E-3 3 146
9 M16932 Top 200 marker genes down-regulated in the 'proliferation' subclass of hepatocellular carcinoma (HCC); characterized by increased proliferation, high levels of serum AFP [GeneID=174], and chromosomal instability. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.558E-5 7.633E-4 5.089E-3 6.870E-3 3 179
10 M5934 Genes encoding proteins involved in processing of drugs and other xenobiotics. MSigDB H: Hallmark Gene Sets (v6.0) 2.171E-5 9.573E-4 6.383E-3 9.573E-3 3 200
11 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 3.930E-5 1.576E-3 1.051E-2 1.733E-2 3 244
12 M3879 Genes down-regulated in tumor compared to non-tumor liver samples from patients with hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.165E-5 3.129E-3 2.086E-2 4.042E-2 2 49
13 17234769-TableS3b Human StemCell West07 97genes GeneSigDB 9.545E-5 3.129E-3 2.086E-2 4.209E-2 2 50
14 12460921-Table2 Human Intestine Hasegawa02 63genes GeneSigDB 9.933E-5 3.129E-3 2.086E-2 4.381E-2 2 51
15 18722011-SuppTable2p Human Leukemia Sanchez-Guijo08 67genes GeneSigDB 1.617E-4 4.737E-3 3.158E-2
7.132E-2
 2 65
16 15757864-Table4 Human Thyroid Forberg05 80genes GeneSigDB 1.719E-4 4.737E-3 3.158E-2
7.579E-2
 2 67
17 M1451 Top 100 probe sets contrubuting to the negative side of the 2nd principal component; associated with adipocytic differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.452E-4 6.360E-3 4.240E-2
1.081E-1
 2 80
18 M19837 Cluster e: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.034E-4 7.434E-3 4.956E-2
1.338E-1
 2 89
19 19171046-tableS1b Human Liver Dong09 120genes GeneSigDB 3.457E-4 8.023E-3
5.349E-2
1.524E-1
 2 95
20 M5451 Survival signature genes defined in adjacent liver tissue: genes correlated with good survival of hepatocellular carcinoma (HCC) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.886E-4 1.077E-2
7.183E-2
2.155E-1
 2 113
21 15785748-Table3 Human Uterine Santin05 178genes GeneSigDB 8.697E-4 1.826E-2
1.218E-1
3.835E-1
 2 151
22 M5935 Genes encoding proteins involved in metabolism of fatty acids. MSigDB H: Hallmark Gene Sets (v6.0) 9.515E-4 1.907E-2
1.272E-1
4.196E-1
 2 158
23 M6235 Genes up-regulated in thymocytes: double negative versus CD8 single positive. MSigDB C7: Immunologic Signatures (v6.0) 1.414E-3 2.390E-2
1.593E-1
6.237E-1
 2 193
24 M8355 Genes down-regulated in atherosclerosis macrophages: anti miR-33 versus anti miR. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 2.390E-2
1.593E-1
6.560E-1
 2 198
25 M6645 Genes up-regulated in bone marrow-derived macrophages at 45 min of stimulation by IL6 [GeneID=3469] and LPS: wildtype versus IL6 [GeneID=3469] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.390E-2
1.593E-1
6.626E-1
 2 199
26 M7025 Genes down-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.390E-2
1.593E-1
6.692E-1
 2 200
27 M8434 Genes down-regulated in CD8 T cells: central memory versus effector memory. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.390E-2
1.593E-1
6.692E-1
 2 200
28 M3423 Genes up-regulated in comparison of effector T cells from IL2RB [GeneID=3560] defficient mice versus effector T cells from wild type animals. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.390E-2
1.593E-1
6.692E-1
 2 200
29 M13273 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.034E-3 3.093E-2
2.062E-1
8.969E-1
 2 232
30 M10759 Top genes associated with favorable overall survival of mesothelioma patients after surgery. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.116E-3 3.111E-2
2.074E-1
9.332E-1
 1 7
31 M9012 Down-regulated genes from the set B (Fig. 5a): specific signature shared by cells expressing either AF4-MLL or MLL-AF4 [GeneID=4299;4297] fusion proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.418E-3 3.440E-2
2.294E-1
1.000E0
 1 8
32 M1834 Genes up-regulated in freshly isolated CD31- [GeneID=5175] (stromal stem cells from adipose tissue) versus the CD31+ (non-stem) counterparts. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.545E-3 3.508E-2
2.339E-1
1.000E0
 2 260
33 M1286 Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.662E-3 3.528E-2
2.352E-1
1.000E0
 2 266
34 19061838-TableS8 Human Viral Cairo08 14genes GeneSigDB 2.720E-3 3.528E-2
2.352E-1
1.000E0
 1 9
35 14767473-SuppTable2 Human Pancreas Nakamura04 346genes GeneSigDB 3.240E-3 3.857E-2
2.572E-1
1.000E0
 2 294
36 M16161 Top genes associated with favorable survival after surgery of patients with epithelioid mesothelioma. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.324E-3 3.857E-2
2.572E-1
1.000E0
 1 11
37 15832406-Table6 Human Stomach Yu04 17genes GeneSigDB 3.324E-3 3.857E-2
2.572E-1
1.000E0
 1 11
38 17115125-Table2 Human Lung not cancer Harvey06 11genes GeneSigDB 3.324E-3 3.857E-2
2.572E-1
1.000E0
 1 11
39 18338247-SuppTable4B Human Breast Harvell08 428genes GeneSigDB 3.617E-3 3.997E-2
2.665E-1
1.000E0
 2 311
40 M5071 Genes up-regulated during transition from G1 (well differentiated tumor, infected with HCV) to G2 (moderately differentiated tumor, infected with HCV) in the development of hepatocellular carcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.625E-3 3.997E-2
2.665E-1
1.000E0
 1 12
41 20421987-TableS6 Human Lung Hou10 17genes GeneSigDB 3.927E-3 4.224E-2
2.816E-1
1.000E0
 1 13
42 M11156 Genes down-regulated in normal tissue adjacent to liver tumor, compared to the normal liver samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.659E-3 4.892E-2
3.262E-1
1.000E0
 2 354
Show 37 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 496 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BM Top 100 - liver BM Top 100 - liver Body Map 5.804E-9 2.879E-6 1.953E-5 2.879E-6 4 80
2 liver liver Human Protein Atlas 5.177E-8 1.284E-5 8.711E-5 2.568E-5 5 419
3 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Hilar/Perihilar/5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Hilar/Perihilar/5 TCGA-Bile Duct 1.082E-7 1.790E-5 1.214E-4 5.369E-5 4 165
4 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5 TCGA-Bile Duct 2.423E-6 2.652E-4 1.799E-3 1.202E-3 3 91
5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/4/3 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/4/3 TCGA-Bile Duct 2.673E-6 2.652E-4 1.799E-3 1.326E-3 3 94
6 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/5 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/5 TCGA-Liver 1.673E-5 1.383E-3 9.382E-3 8.297E-3 3 173
7 BM Top 100 - colon cecum BM Top 100 - colon cecum Body Map 2.047E-4 1.306E-2
8.862E-2
1.015E-1
 2 69
8 BM Top 100 - stomach pyloric BM Top 100 - stomach pyloric Body Map 2.107E-4 1.306E-2
8.862E-2
1.045E-1
 2 70
9 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Undifferentiated Pleomorphic Sarcoma/1/2 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Undifferentiated Pleomorphic Sarcoma/1/2 TCGA-Bone and Soft Tissue 4.559E-4 2.305E-2
1.564E-1
2.261E-1
 2 103
10 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Acinar Adenocarcinoma/4/2 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Acinar Adenocarcinoma/4/2 TCGA-Lung 4.648E-4 2.305E-2
1.564E-1
2.305E-1
 2 104
11 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/1/3 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/1/3 TCGA-Pancreas 5.292E-4 2.386E-2
1.619E-1
2.625E-1
 2 111
12 geo heart 500 K2 geo heart top-relative-expression-ranked 500 k-means-cluster#2 PCBC 5.978E-4 2.471E-2
1.676E-1
2.965E-1
 2 118
13 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - NOS/0 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - NOS/0 TCGA-Stomach 6.598E-4 2.517E-2
1.708E-1
3.273E-1
 2 124
14 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma/Myxofibrosarcoma/1/0 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma/Myxofibrosarcoma/1/0 TCGA-Bone and Soft Tissue 8.881E-4 2.699E-2
1.831E-1
4.405E-1
 2 144
15 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B2/2/2 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B2/2/2 TCGA-Thymus 8.881E-4 2.699E-2
1.831E-1
4.405E-1
 2 144
16 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/1/0 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/1/0 TCGA-Liver 8.881E-4 2.699E-2
1.831E-1
4.405E-1
 2 144
17 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Squamous Cell Carcinoma/4/0 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Squamous Cell Carcinoma/4/0 TCGA-Lung 9.252E-4 2.699E-2
1.831E-1
4.589E-1
 2 147
18 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Mucinous/2/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Mucinous/2/3 TCGA-Stomach 1.081E-3 2.857E-2
1.938E-1
5.361E-1
 2 159
19 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Biphasic/1/1 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Biphasic/1/1 TCGA-Mesothelium 1.094E-3 2.857E-2
1.938E-1
5.428E-1
 2 160
20 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Acinar Adenocarcinoma/5 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Acinar Adenocarcinoma/5 TCGA-Lung 1.234E-3 3.028E-2
2.055E-1
6.121E-1
 2 170
21 gudmap dev gonad e12.5 M gudmap devVasTestis Flk k2 100 dev gonad e12.5 M DevVasTestis Flk k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 1.282E-3 3.028E-2
2.055E-1
6.360E-1
 1 4
22 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/6 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/6 TCGA-Breast 1.412E-3 3.146E-2
2.135E-1
7.006E-1
 2 182
23 Sample Type by Project: Shred 1/TCGA-Adrenal Cortex/Adrenocortical carcinoma/Oncocytic Type/4 Sample Type by Project: Shred 1/TCGA-Adrenal Cortex/Adrenocortical carcinoma/Oncocytic Type/4 TCGA-Adrenal Cortex 1.459E-3 3.146E-2
2.135E-1
7.236E-1
 2 185
24 gudmap dev gonad e13.5 M SertoliCell Sox9 k2 100 dev gonad e13.5 M SertoliCell Sox9 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 1.602E-3 3.277E-2
2.223E-1
7.948E-1
 1 5
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter others/Kidney Normal-Medulla Wilms Ureter others Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter others/Kidney Normal-Medulla Wilms Ureter others Adult, Development, and Cancer types 1.652E-3 3.277E-2
2.223E-1
8.193E-1
 2 197
26 gudmap developingLowerUrinaryTract P1 ureter 1000 k3 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.035E-3 3.883E-2
2.635E-1
1.000E0
 2 219
27 Sample Type by Project: Shred 1/TCGA-Thryoid/Thyroid Papillary Carcinoma/Tall Cell/3/3 Sample Type by Project: Shred 1/TCGA-Thryoid/Thyroid Papillary Carcinoma/Tall Cell/3/3 TCGA-Thryoid 2.243E-3 3.973E-2
2.696E-1
1.000E0
 1 7
28 gudmap dev gonad e12.5 M SertoliCell Sox9 k4 100 dev gonad e12.5 M SertoliCell Sox9 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 2.243E-3 3.973E-2
2.696E-1
1.000E0
 1 7
Show 23 more annotations

15: Computational [Display Chart] 7 input genes in category / 34 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14076 MODULE 373 Oxidoreductases. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.503E-13 2.211E-11 9.105E-11 2.211E-11 5 22
2 M19454 MODULE 514 Genes in the cancer module 514. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.737E-11 2.952E-10 1.216E-9 5.905E-10 4 10
3 M18034 CAR IGFBP1 Neighborhood of IGFBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.230E-8 3.661E-7 1.508E-6 1.098E-6 4 57
4 M4515 MODULE 324 Metal / Ca ion binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.000E-6 8.502E-6 3.501E-5 3.401E-5 4 133
5 M18033 MODULE 286 Genes in the cancer module 286 MSigDb: C4 - CM: Cancer Modules (v6.0) 1.598E-6 1.087E-5 4.475E-5 5.433E-5 3 37
6 M10134 MODULE 93 Oxidoreductases. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.509E-6 1.988E-5 8.189E-5 1.193E-4 4 182
7 M57 MODULE 247 Xenobiotic metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.745E-4 1.333E-3 5.490E-3 9.332E-3 2 37
8 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.467E-3 1.048E-2 4.318E-2
8.387E-2
 3 434
9 M132 GNF2 LCAT Neighborhood of LCAT MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.053E-3 1.115E-2 4.593E-2
1.038E-1
 2 124
10 M10917 GNF2 HPN Neighborhood of HPN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.504E-3 1.115E-2 4.593E-2
1.191E-1
 2 133
11 M14108 GNF2 HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.608E-3 1.115E-2 4.593E-2
1.227E-1
 2 135
12 M443 MODULE 377 Energy pathways and carbohydrate metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.649E-3 2.167E-2
8.925E-2
2.601E-1
 1 11
13 M12644 MODULE 272 Genes in the cancer module 272. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.342E-3 2.182E-2
8.984E-2
2.836E-1
 1 12
14 M8613 MODULE 519 Oxidoreductases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.042E-2 2.530E-2
1.042E-1
3.542E-1
 1 15
15 M16314 GNF2 IGF1 Neighborhood of IGF1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.800E-2 3.923E-2
1.616E-1
6.119E-1
 1 26
16 M2667 MODULE 19 Adrenal gland - metabolic genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.846E-2 3.923E-2
1.616E-1
6.277E-1
 2 314
17 M3463 MODULE 44 Thymus genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.994E-2 3.988E-2
1.642E-1
6.779E-1
 2 327
Show 12 more annotations

16: MicroRNA [Display Chart] 7 input genes in category / 120 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-135b*:mirSVR highEffct hsa-miR-135b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.766E-6 9.319E-4 5.003E-3 9.319E-4 3 441
2 hsa-miR-1286:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.208E-5 2.525E-3 1.356E-2 5.050E-3 2 103
3 hsa-miR-873-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.802E-4 1.121E-2
6.018E-2
 3.363E-2 2 266
4 hsa-miR-6841-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.420E-3 2.968E-2
1.594E-1
2.904E-1
 1 25
5 hsa-miR-520g-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.580E-3 2.968E-2
1.594E-1
4.296E-1
 1 37
6 hsa-miR-549a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-3 2.968E-2
1.594E-1
5.802E-1
 1 50
7 hsa-miR-6510-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 2.968E-2
1.594E-1
6.149E-1
 1 53
8 hsa-miR-4777-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.317E-3 2.968E-2
1.594E-1
6.381E-1
 1 55
9 hsa-miR-523-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
10 hsa-miR-519b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
11 hsa-miR-526a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
12 hsa-miR-518e-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
13 hsa-miR-518d-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
14 hsa-miR-519c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
15 hsa-miR-519a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
16 hsa-miR-518f-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
17 hsa-miR-520c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
18 hsa-miR-3189-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 2.968E-2
1.594E-1
7.075E-1
 1 61
19 hsa-miR-522-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.992E-3 2.968E-2
1.594E-1
7.191E-1
 1 62
20 hsa-miR-4705:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 2.968E-2
1.594E-1
7.422E-1
 1 64
21 hsa-miR-4758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.282E-3 2.968E-2
1.594E-1
7.538E-1
 1 65
22 hsa-miR-4764-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 2.968E-2
1.594E-1
8.001E-1
 1 69
23 hsa-miR-4280:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 2.968E-2
1.594E-1
8.116E-1
 1 70
24 hsa-miR-5699-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.763E-3 2.968E-2
1.594E-1
8.116E-1
 1 70
25 hsa-miR-1265:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 2.968E-2
1.594E-1
8.347E-1
 1 72
26 hsa-miR-1247:mirSVR highEffct hsa-miR-1247:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.052E-3 2.968E-2
1.594E-1
8.463E-1
 1 73
27 hsa-miR-568:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.149E-3 2.968E-2
1.594E-1
8.578E-1
 1 74
28 hsa-miR-5087:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 2.968E-2
1.594E-1
9.618E-1
 1 83
29 hsa-miR-4666a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-3 2.968E-2
1.594E-1
9.734E-1
 1 84
30 hsa-miR-376c-3p:Functional MTI Functional MTI miRTarbase 8.111E-3 2.968E-2
1.594E-1
9.734E-1
 1 84
31 hsa-miR-4464:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 2.968E-2
1.594E-1
1.000E0
 1 89
32 hsa-miR-4748:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.689E-3 2.968E-2
1.594E-1
1.000E0
 1 90
33 hsa-miR-8087:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.073E-3 2.968E-2
1.594E-1
1.000E0
 1 94
34 hsa-miR-548u:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.746E-3 2.968E-2
1.594E-1
1.000E0
 1 101
35 hsa-miR-657:Functional MTI Functional MTI miRTarbase 9.842E-3 2.968E-2
1.594E-1
1.000E0
 1 102
36 hsa-miR-8068:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.842E-3 2.968E-2
1.594E-1
1.000E0
 1 102
37 hsa-miR-7161-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.938E-3 2.968E-2
1.594E-1
1.000E0
 1 103
38 hsa-miR-4666a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.032E-2 2.968E-2
1.594E-1
1.000E0
 1 107
39 hsa-miR-1973:mirSVR highEffct hsa-miR-1973:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.061E-2 2.968E-2
1.594E-1
1.000E0
 1 110
40 hsa-miR-4715-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.090E-2 2.968E-2
1.594E-1
1.000E0
 1 113
41 hsa-let-7f-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.099E-2 2.968E-2
1.594E-1
1.000E0
 1 114
42 hsa-miR-98-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.099E-2 2.968E-2
1.594E-1
1.000E0
 1 114
43 hsa-let-7b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.119E-2 2.968E-2
1.594E-1
1.000E0
 1 116
44 hsa-miR-3944-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 2.968E-2
1.594E-1
1.000E0
 1 117
45 hsa-miR-300:Functional MTI Functional MTI miRTarbase 1.138E-2 2.968E-2
1.594E-1
1.000E0
 1 118
46 hsa-miR-5589-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.138E-2 2.968E-2
1.594E-1
1.000E0
 1 118
47 hsa-let-7a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.186E-2 2.984E-2
1.602E-1
1.000E0
 1 123
48 hsa-miR-4709-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.215E-2 2.984E-2
1.602E-1
1.000E0
 1 126
49 hsa-miR-4451:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.234E-2 2.984E-2
1.602E-1
1.000E0
 1 128
50 hsa-miR-6872-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.243E-2 2.984E-2
1.602E-1
1.000E0
 1 129
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1039 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000074128 2-NA Stitch 5.599E-26 2.909E-23 2.188E-22 5.818E-23 7 9
2 CID000440672 (3R,7R)-17-(6-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol Stitch 5.599E-26 2.909E-23 2.188E-22 5.818E-23 7 9
3 CID000008104 hexa-2,4-dien-1-ol Stitch 1.232E-24 4.266E-22 3.210E-21 1.280E-21 7 12
4 CID000006201 2-naphthaldehyde Stitch 2.669E-24 6.933E-22 5.216E-21 2.773E-21 7 13
5 CID000020908 naphthalenemethanol Stitch 5.338E-24 1.109E-21 8.345E-21 5.546E-21 7 14
6 CID000440673 6-[(3R,7R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptanal Stitch 1.001E-23 1.733E-21 1.304E-20 1.040E-20 7 15
7 CID000006195 naphthaldehyde Stitch 1.779E-23 2.641E-21 1.987E-20 1.849E-20 7 16
8 CID000151725 dhmal Stitch 2.428E-21 3.153E-19 2.372E-18 2.522E-18 7 29
9 CID000001082 AC1L1AOQ Stitch 3.166E-21 3.655E-19 2.750E-18 3.290E-18 7 30
10 CID000005123 willardine Stitch 5.235E-21 5.439E-19 4.092E-18 5.439E-18 7 32
11 CID000091528 DOPEG Stitch 1.298E-20 1.226E-18 9.227E-18 1.349E-17 7 36
12 CID000030201 AC1L1J0I Stitch 3.281E-20 2.841E-18 2.137E-17 3.409E-17 6 12
13 CID000008259 2,2,2-trichloroethanol Stitch 2.534E-18 2.025E-16 1.524E-15 2.633E-15 7 73
14 CID000000244 benzyl alcohol Stitch 6.458E-18 4.792E-16 3.606E-15 6.709E-15 7 83
15 DB01907 Nicotinamide-Adenine-Dinucleotide Drug Bank 1.362E-16 9.431E-15 7.095E-14 1.415E-13 6 40
16 CID000002707 chloral hydrate Stitch 1.555E-16 1.009E-14 7.595E-14 1.615E-13 7 129
17 CID000000751 glyceraldehyde Stitch 2.793E-16 1.697E-14 1.276E-13 2.902E-13 7 140
18 CID000001048 1H-pyrazol Stitch 2.939E-16 1.697E-14 1.276E-13 3.054E-13 7 141
19 ctd:D019855 Ethylene Glycol CTD 8.242E-15 4.363E-13 3.282E-12 8.564E-12 5 21
20 ctd:D002927 Cimetidine CTD 8.398E-15 4.363E-13 3.282E-12 8.726E-12 6 77
21 CID000003406 4-methylpyrazole Stitch 1.439E-14 7.122E-13 5.358E-12 1.496E-11 6 84
22 CID000008133 2-butoxyethanol Stitch 1.721E-14 8.129E-13 6.116E-12 1.788E-11 5 24
23 ctd:C010238 fomepizole CTD 3.269E-14 1.477E-12 1.111E-11 3.396E-11 5 27
24 ctd:C574123 walrycin A CTD 8.150E-14 3.528E-12 2.655E-11 8.468E-11 5 32
25 CID000000177 acetaldehyde Stitch 1.461E-13 6.072E-12 4.568E-11 1.518E-10 7 338
26 CID000000928 reduced diphosphopyridine nucleotide Stitch 1.588E-13 6.344E-12 4.773E-11 1.650E-10 7 342
27 CID000001071 9-cis-retinol Stitch 2.150E-13 8.015E-12 6.030E-11 2.233E-10 7 357
28 CID000347402 N-heptylformamide Stitch 2.160E-13 8.015E-12 6.030E-11 2.244E-10 4 8
29 ctd:D019840 2-Propanol CTD 2.329E-13 8.344E-12 6.278E-11 2.420E-10 5 39
30 DB00157 NADH Drug Bank 3.937E-13 1.364E-11 1.026E-10 4.091E-10 6 144
31 CID000003117 disulfiram Stitch 6.932E-13 2.323E-11 1.748E-10 7.202E-10 6 158
32 CID000008076 EGEE Stitch 9.494E-13 3.083E-11 2.319E-10 9.864E-10 5 51
33 CID000013577 hex-2-en-1-ol Stitch 1.018E-12 3.205E-11 2.411E-10 1.058E-9 4 11
34 CID000000929 beta-NADP Stitch 2.005E-12 6.118E-11 4.603E-10 2.083E-9 7 490
35 CID000001070 11-cis-retinal Stitch 2.061E-12 6.118E-11 4.603E-10 2.141E-9 6 189
36 CID000000957 octanol Stitch 3.608E-12 1.041E-10 7.835E-10 3.749E-9 5 66
37 CID000031236 phenoxyethanol Stitch 5.611E-12 1.576E-10 1.186E-9 5.830E-9 4 16
38 CID000003514 AC1L1G3W Stitch 8.130E-12 2.223E-10 1.672E-9 8.447E-9 6 237
39 CID000013017 C x F Stitch 1.195E-11 3.183E-10 2.395E-9 1.241E-8 4 19
40 DB02721 4-Iodopyrazole Drug Bank 1.763E-11 4.578E-10 3.444E-9 1.831E-8 3 3
41 DB01213 Fomepizole Drug Bank 7.049E-11 1.786E-9 1.344E-8 7.324E-8 3 4
42 ctd:D012172 Retinaldehyde CTD 3.441E-10 8.514E-9 6.405E-8 3.576E-7 4 42
43 DB00898 Ethanol Drug Bank 6.166E-10 1.490E-8 1.121E-7 6.406E-7 3 7
44 CID000079034 1-2H Stitch 1.302E-9 3.075E-8 2.314E-7 1.353E-6 4 58
45 CID000000887 methanol Stitch 1.917E-9 4.402E-8 3.312E-7 1.992E-6 5 227
46 CID000007858 allyl alcohol Stitch 1.949E-9 4.402E-8 3.312E-7 2.025E-6 4 64
47 CID000029025 verbenone Stitch 2.113E-9 4.671E-8 3.514E-7 2.195E-6 3 10
48 CID000011552 3-methylbutanal Stitch 5.034E-9 1.090E-7 8.198E-7 5.230E-6 3 13
49 CID003034285 azoxystrobin Stitch 7.135E-9 1.513E-7 1.138E-6 7.413E-6 4 88
50 CID005483934 Peony Stitch 2.005E-8 4.166E-7 3.134E-6 2.083E-5 3 20
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 126 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0747548 Pharyngeal Carcinoma DisGeNET BeFree 9.572E-14 1.206E-11 6.534E-11 1.206E-11 5 24
2 C0153405 Malignant neoplasm of pharynx DisGeNET BeFree 5.340E-13 3.364E-11 1.823E-10 6.728E-11 5 33
3 C0007107 Malignant neoplasm of larynx DisGeNET BeFree 1.812E-12 7.609E-11 4.122E-10 2.283E-10 6 132
4 C0877008 Enzyme inhibition disorder DisGeNET BeFree 2.441E-12 7.688E-11 4.165E-10 3.075E-10 5 44
5 C0001973 Alcoholic Intoxication, Chronic DisGeNET Curated 5.493E-12 1.384E-10 7.499E-10 6.921E-10 7 402
6 C0595989 Carcinoma of larynx DisGeNET Curated 8.775E-12 1.843E-10 9.983E-10 1.106E-9 6 171
7 C4048195 Autosomal dominant hypocalcemia DisGeNET BeFree 2.241E-8 4.033E-7 2.185E-6 2.823E-6 3 15
8 C0376670 Pancreatitis, Alcoholic DisGeNET Curated 9.951E-8 1.567E-6 8.491E-6 1.254E-5 3 24
9 C0038580 Substance Dependence DisGeNET BeFree 2.678E-7 3.749E-6 2.031E-5 3.374E-5 3 33
10 C0153382 Malignant neoplasm of oropharynx DisGeNET BeFree 3.503E-7 4.413E-6 2.391E-5 4.413E-5 3 36
11 C0031347 Pharyngeal Neoplasms DisGeNET Curated 4.797E-7 5.495E-6 2.977E-5 6.045E-5 2 3
12 C2349952 Oropharyngeal Carcinoma DisGeNET BeFree 1.282E-6 1.347E-5 7.295E-5 1.616E-4 3 55
13 C0001956 alcohol use disorder DisGeNET Curated 1.938E-6 1.879E-5 1.018E-4 2.442E-4 3 63
14 cv:CN028882 Alcohol dependence Clinical Variations 2.397E-6 1.925E-5 1.043E-4 3.021E-4 2 6
15 OMIN:103780 ALCOHOL DEPENDENCE OMIM 2.397E-6 1.925E-5 1.043E-4 3.021E-4 2 6
16 C0026640 Mouth Neoplasms DisGeNET Curated 2.444E-6 1.925E-5 1.043E-4 3.079E-4 3 68
17 C0085762 Alcohol abuse DisGeNET Curated 3.703E-6 2.745E-5 1.487E-4 4.666E-4 3 78
18 C0016382 Flushing DisGeNET Curated 4.974E-6 3.482E-5 1.886E-4 6.267E-4 3 86
19 C0028043 Nicotine Dependence DisGeNET BeFree 1.225E-5 8.124E-5 4.401E-4 1.544E-3 3 116
20 C0023055 Laryngeal neoplasm DisGeNET Curated 2.169E-5 1.366E-4 7.401E-4 2.732E-3 2 17
21 C0156312 Atrophy of testis DisGeNET Curated 3.028E-5 1.817E-4 9.842E-4 3.815E-3 2 20
22 C0030305 Pancreatitis DisGeNET Curated 3.782E-5 2.166E-4 1.173E-3 4.765E-3 3 169
23 C0087169 Withdrawal Symptoms DisGeNET BeFree 4.395E-5 2.407E-4 1.304E-3 5.537E-3 2 24
24 C0687132 heavy drinking DisGeNET Curated 1.058E-4 5.552E-4 3.008E-3 1.333E-2 2 37
25 C0001969 Alcoholic Intoxication DisGeNET Curated 1.366E-4 6.884E-4 3.729E-3 1.721E-2 2 42
26 C0149521 Pancreatitis, Chronic DisGeNET Curated 1.807E-4 8.755E-4 4.743E-3 2.276E-2 3 286
27 C0220810 Congenital defects DisGeNET BeFree 2.436E-4 1.137E-3 6.158E-3 3.069E-2 2 56
28 C0013295 Duodenal Ulcer DisGeNET Curated 2.892E-4 1.301E-3 7.050E-3 3.644E-2 2 61
29 C0042721 Viral hepatitis DisGeNET Curated 3.085E-4 1.337E-3 7.244E-3 3.887E-2 2 63
30 C1510472 Drug Dependence DisGeNET BeFree 3.184E-4 1.337E-3 7.244E-3 4.011E-2 2 64
31 C0023891 Liver Cirrhosis, Alcoholic DisGeNET Curated 4.257E-4 1.701E-3 9.214E-3
5.363E-2
 2 74
32 C0740703 ABUSE NEGLECT DisGeNET BeFree 4.320E-4 1.701E-3 9.214E-3
5.443E-2
 1 1
33 C0023896 Alcoholic Liver Diseases DisGeNET Curated 5.353E-4 2.044E-3 1.107E-2
6.745E-2
 2 83
34 20090812:Adeyemo Hypertension GWAS 8.638E-4 2.941E-3 1.594E-2
1.088E-1
 1 2
35 C0810031 alcohol-related liver disease DisGeNET BeFree 8.638E-4 2.941E-3 1.594E-2
1.088E-1
 1 2
36 C0556374 Drunk driving DisGeNET BeFree 8.638E-4 2.941E-3 1.594E-2
1.088E-1
 1 2
37 C0085677 Alcoholic Neuropathy DisGeNET BeFree 8.638E-4 2.941E-3 1.594E-2
1.088E-1
 1 2
38 C0013146 Drug abuse DisGeNET BeFree 1.133E-3 3.757E-3 2.035E-2
1.428E-1
 2 121
39 C0683357 excessive drinking DisGeNET Curated 1.295E-3 4.081E-3 2.211E-2
1.632E-1
 1 3
40 C0393756 Hangover from alcohol DisGeNET Curated 1.295E-3 4.081E-3 2.211E-2
1.632E-1
 1 3
41 C1266025 Traditional Serrated Adenoma DisGeNET BeFree 1.367E-3 4.200E-3 2.275E-2
1.722E-1
 2 133
42 C0394996 Acute alcoholic intoxication DisGeNET Curated 1.727E-3 4.709E-3 2.551E-2
2.176E-1
 1 4
43 C0683342 hazardous drinking DisGeNET BeFree 1.727E-3 4.709E-3 2.551E-2
2.176E-1
 1 4
44 C3146244 Alcohol Related Birth Defect DisGeNET Curated 1.727E-3 4.709E-3 2.551E-2
2.176E-1
 1 4
45 C3699402 Alcohol abuse or dependence DisGeNET BeFree 1.727E-3 4.709E-3 2.551E-2
2.176E-1
 1 4
46 C0679414 alcohol flush reaction DisGeNET BeFree 1.727E-3 4.709E-3 2.551E-2
2.176E-1
 1 4
47 C0162309 Adrenoleukodystrophy DisGeNET Curated 1.757E-3 4.709E-3 2.551E-2
2.213E-1
 2 151
48 C0349464 Wernicke-Korsakoff Syndrome DisGeNET Curated 2.589E-3 6.397E-3 3.466E-2
3.263E-1
 1 6
49 C1542327 Fetus or newborn affected by alcohol transmitted via placenta or breast milk DisGeNET Curated 2.589E-3 6.397E-3 3.466E-2
3.263E-1
 1 6
50 C0236664 Alcohol-Related Disorders DisGeNET Curated 2.589E-3 6.397E-3 3.466E-2
3.263E-1
 1 6
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