|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
18509327
|
Pharmacogenetic pathway analysis of docetaxel elimination.
|
Pubmed
|
1.974E-15
|
6.135E-12
|
5.568E-11
|
9.683E-12
|
4
|
5
|
2
|
20173083
|
Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.
|
Pubmed
|
2.502E-15
|
6.135E-12
|
5.568E-11
|
1.227E-11
|
5
|
27
|
3
|
18294295
|
Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.
|
Pubmed
|
1.382E-14
|
1.694E-11
|
1.538E-10
|
6.777E-11
|
4
|
7
|
4
|
18979093
|
Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam.
|
Pubmed
|
1.382E-14
|
1.694E-11
|
1.538E-10
|
6.777E-11
|
4
|
7
|
5
|
19343046
|
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
|
Pubmed
|
1.074E-13
|
1.053E-10
|
9.557E-10
|
5.266E-10
|
6
|
193
|
6
|
20679960
|
Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.
|
Pubmed
|
2.765E-13
|
1.977E-10
|
1.794E-9
|
1.356E-9
|
5
|
66
|
7
|
16771603
|
Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population.
|
Pubmed
|
2.821E-13
|
1.977E-10
|
1.794E-9
|
1.384E-9
|
4
|
13
|
8
|
21072184
|
Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
|
Pubmed
|
1.911E-12
|
1.172E-9
|
1.063E-8
|
9.374E-9
|
4
|
20
|
9
|
19956635
|
Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.
|
Pubmed
|
3.442E-12
|
1.876E-9
|
1.702E-8
|
1.688E-8
|
5
|
108
|
10
|
19865079
|
Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients.
|
Pubmed
|
1.508E-11
|
6.723E-9
|
6.102E-8
|
7.395E-8
|
3
|
4
|
11
|
19228751
|
Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma.
|
Pubmed
|
1.508E-11
|
6.723E-9
|
6.102E-8
|
7.395E-8
|
3
|
4
|
12
|
11809184
|
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study.
|
Pubmed
|
3.769E-11
|
1.232E-8
|
1.119E-7
|
1.849E-7
|
3
|
5
|
13
|
18382661
|
Pharmacokinetic genes do not influence response or tolerance to citalopram in the STAR*D sample.
|
Pubmed
|
3.769E-11
|
1.232E-8
|
1.119E-7
|
1.849E-7
|
3
|
5
|
14
|
20656072
|
Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.
|
Pubmed
|
3.769E-11
|
1.232E-8
|
1.119E-7
|
1.849E-7
|
3
|
5
|
15
|
19659438
|
CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.
|
Pubmed
|
3.769E-11
|
1.232E-8
|
1.119E-7
|
1.849E-7
|
3
|
5
|
16
|
20720558
|
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia.
|
Pubmed
|
7.538E-11
|
1.849E-8
|
1.678E-7
|
3.697E-7
|
3
|
6
|
17
|
20212519
|
Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.
|
Pubmed
|
7.538E-11
|
1.849E-8
|
1.678E-7
|
3.697E-7
|
3
|
6
|
18
|
18192894
|
Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms.
|
Pubmed
|
7.538E-11
|
1.849E-8
|
1.678E-7
|
3.697E-7
|
3
|
6
|
19
|
18518855
|
A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine.
|
Pubmed
|
7.538E-11
|
1.849E-8
|
1.678E-7
|
3.697E-7
|
3
|
6
|
20
|
15801936
|
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer.
|
Pubmed
|
7.538E-11
|
1.849E-8
|
1.678E-7
|
3.697E-7
|
3
|
6
|
21
|
19842932
|
Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.
|
Pubmed
|
1.319E-10
|
3.081E-8
|
2.796E-7
|
6.470E-7
|
3
|
7
|
22
|
20147896
|
A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.
|
Pubmed
|
2.110E-10
|
4.313E-8
|
3.914E-7
|
1.035E-6
|
3
|
8
|
23
|
18356043
|
Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.
|
Pubmed
|
2.110E-10
|
4.313E-8
|
3.914E-7
|
1.035E-6
|
3
|
8
|
24
|
15680923
|
Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes.
|
Pubmed
|
2.110E-10
|
4.313E-8
|
3.914E-7
|
1.035E-6
|
3
|
8
|
25
|
17178267
|
ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.
|
Pubmed
|
3.165E-10
|
6.210E-8
|
5.636E-7
|
1.552E-6
|
3
|
9
|
26
|
19651758
|
Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.
|
Pubmed
|
4.521E-10
|
8.213E-8
|
7.454E-7
|
2.218E-6
|
3
|
10
|
27
|
12960109
|
Irinotecan pathway genotype analysis to predict pharmacokinetics.
|
Pubmed
|
4.521E-10
|
8.213E-8
|
7.454E-7
|
2.218E-6
|
3
|
10
|
28
|
15469410
|
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
|
Pubmed
|
6.216E-10
|
1.016E-7
|
9.223E-7
|
3.049E-6
|
3
|
11
|
29
|
18695635
|
Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.
|
Pubmed
|
6.216E-10
|
1.016E-7
|
9.223E-7
|
3.049E-6
|
3
|
11
|
30
|
15039299
|
Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.
|
Pubmed
|
6.216E-10
|
1.016E-7
|
9.223E-7
|
3.049E-6
|
3
|
11
|
31
|
19349540
|
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
|
Pubmed
|
8.287E-10
|
1.311E-7
|
1.190E-6
|
4.065E-6
|
3
|
12
|
32
|
19636001
|
Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: a subgroup analysis of a large randomized clinical trial.
|
Pubmed
|
1.371E-9
|
2.038E-7
|
1.849E-6
|
6.725E-6
|
3
|
14
|
33
|
20970553
|
Toward personalized medicine in renal transplantation.
|
Pubmed
|
1.371E-9
|
2.038E-7
|
1.849E-6
|
6.725E-6
|
3
|
14
|
34
|
19575027
|
Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility.
|
Pubmed
|
1.714E-9
|
2.472E-7
|
2.244E-6
|
8.405E-6
|
3
|
15
|
35
|
20136364
|
Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip.
|
Pubmed
|
2.109E-9
|
2.873E-7
|
2.608E-6
|
1.034E-5
|
3
|
16
|
36
|
17925548
|
Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer.
|
Pubmed
|
2.109E-9
|
2.873E-7
|
2.608E-6
|
1.034E-5
|
3
|
16
|
37
|
9890157
|
Molecular genetics of the human cytochrome P450 monooxygenase superfamily.
|
Pubmed
|
4.292E-9
|
5.689E-7
|
5.163E-6
|
2.105E-5
|
3
|
20
|
38
|
16006997
|
A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
|
Pubmed
|
8.655E-9
|
1.117E-6
|
1.014E-5
|
4.245E-5
|
3
|
25
|
39
|
20031551
|
Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.
|
Pubmed
|
1.691E-8
|
1.702E-6
|
1.544E-5
|
8.293E-5
|
3
|
31
|
40
|
24510399
|
Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
41
|
15820320
|
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
42
|
19405050
|
Characterization of pharmacogenetically relevant CYP2D6 and ABCB1 gene polymorphisms in a Portuguese population sample.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
43
|
21039333
|
Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
44
|
22398969
|
Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
45
|
25868121
|
The Influence of the CYP3A4*22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole, Haloperidol, Pimozide, and Risperidone in Psychiatric Patients.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
46
|
16611851
|
Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
47
|
19802823
|
Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
48
|
21589866
|
Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
49
|
16633141
|
Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharmacodynamics of haloperidol in healthy subjects.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|
50
|
18641553
|
CYP2D6 and ABCB1 genetic variability: influence on paroxetine plasma level and therapeutic response.
|
Pubmed
|
2.879E-8
|
1.702E-6
|
1.544E-5
|
1.412E-4
|
2
|
2
|