Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc373_8, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 32 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1.522E-12 4.869E-11 1.976E-10 4.869E-11 5 46
2 GO:0004713 protein tyrosine kinase activity 1.727E-9 2.762E-8 1.121E-7 5.525E-8 5 182
3 GO:0045295 gamma-catenin binding 4.867E-3 3.284E-2
1.333E-1
1.557E-1
 1 13
4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5.987E-3 3.284E-2
1.333E-1
1.916E-1
 1 16
5 GO:0030553 cGMP binding 6.361E-3 3.284E-2
1.333E-1
2.035E-1
 1 17
6 GO:0008157 protein phosphatase 1 binding 8.225E-3 3.284E-2
1.333E-1
2.632E-1
 1 22
7 GO:0034987 immunoglobulin receptor binding 1.046E-2 3.284E-2
1.333E-1
3.346E-1
 1 28
8 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1.120E-2 3.284E-2
1.333E-1
3.584E-1
 1 30
9 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1.157E-2 3.284E-2
1.333E-1
3.703E-1
 1 31
10 GO:0030507 spectrin binding 1.194E-2 3.284E-2
1.333E-1
3.822E-1
 1 32
11 GO:0045296 cadherin binding 1.194E-2 3.284E-2
1.333E-1
3.822E-1
 1 32
12 GO:0005154 epidermal growth factor receptor binding 1.232E-2 3.284E-2
1.333E-1
3.941E-1
 1 33
13 GO:0030551 cyclic nucleotide binding 1.528E-2 3.762E-2
1.527E-1
4.890E-1
 1 41
Show 8 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 234 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0038083 peptidyl-tyrosine autophosphorylation 1.720E-12 4.025E-10 2.429E-9 4.025E-10 5 47
2 GO:0046777 protein autophosphorylation 7.777E-9 9.099E-7 5.491E-6 1.820E-6 5 245
3 GO:0018108 peptidyl-tyrosine phosphorylation 7.469E-8 3.886E-6 2.345E-5 1.748E-5 5 385
4 GO:0018212 peptidyl-tyrosine modification 7.665E-8 3.886E-6 2.345E-5 1.794E-5 5 387
5 GO:0007173 epidermal growth factor receptor signaling pathway 8.302E-8 3.886E-6 2.345E-5 1.943E-5 4 132
6 GO:0038127 ERBB signaling pathway 1.427E-7 5.563E-6 3.357E-5 3.338E-5 4 151
7 GO:0042058 regulation of epidermal growth factor receptor signaling pathway 3.170E-6 1.030E-4 6.213E-4 7.417E-4 3 85
8 GO:1901184 regulation of ERBB signaling pathway 3.520E-6 1.030E-4 6.213E-4 8.237E-4 3 88
9 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 7.163E-5 1.479E-3 8.924E-3 1.676E-2 2 35
10 GO:1901186 positive regulation of ERBB signaling pathway 7.583E-5 1.479E-3 8.924E-3 1.775E-2 2 36
11 GO:0033006 regulation of mast cell activation involved in immune response 7.583E-5 1.479E-3 8.924E-3 1.775E-2 2 36
12 GO:0043304 regulation of mast cell degranulation 7.583E-5 1.479E-3 8.924E-3 1.775E-2 2 36
13 GO:0033003 regulation of mast cell activation 1.190E-4 2.142E-3 1.292E-2 2.784E-2 2 45
14 GO:0043300 regulation of leukocyte degranulation 1.299E-4 2.171E-3 1.310E-2 3.039E-2 2 47
15 GO:0002886 regulation of myeloid leukocyte mediated immunity 1.471E-4 2.191E-3 1.322E-2 3.442E-2 2 50
16 GO:0043303 mast cell degranulation 1.592E-4 2.191E-3 1.322E-2 3.724E-2 2 52
17 GO:0002279 mast cell activation involved in immune response 1.592E-4 2.191E-3 1.322E-2 3.724E-2 2 52
18 GO:0002448 mast cell mediated immunity 1.717E-4 2.232E-3 1.347E-2 4.018E-2 2 54
19 GO:0032418 lysosome localization 2.051E-4 2.526E-3 1.524E-2 4.800E-2 2 59
20 GO:0045576 mast cell activation 2.807E-4 3.285E-3 1.982E-2
6.569E-2
 2 69
21 GO:0043254 regulation of protein complex assembly 3.228E-4 3.435E-3 2.073E-2
7.554E-2
 3 400
22 GO:0043299 leukocyte degranulation 3.229E-4 3.435E-3 2.073E-2
7.556E-2
 2 74
23 GO:0002275 myeloid cell activation involved in immune response 3.774E-4 3.772E-3 2.276E-2
8.831E-2
 2 80
24 GO:0007260 tyrosine phosphorylation of STAT protein 3.869E-4 3.772E-3 2.276E-2
9.053E-2
 2 81
25 GO:0031532 actin cytoskeleton reorganization 4.775E-4 4.469E-3 2.697E-2
1.117E-1
 2 90
26 GO:0002444 myeloid leukocyte mediated immunity 4.988E-4 4.490E-3 2.709E-2
1.167E-1
 2 92
27 GO:0032273 positive regulation of protein polymerization 7.779E-4 6.742E-3 4.069E-2
1.820E-1
 2 115
28 GO:0036215 response to stem cell factor 1.127E-3 8.793E-3
5.306E-2
2.638E-1
 1 3
29 GO:0038109 Kit signaling pathway 1.127E-3 8.793E-3
5.306E-2
2.638E-1
 1 3
30 GO:0036216 cellular response to stem cell factor stimulus 1.127E-3 8.793E-3
5.306E-2
2.638E-1
 1 3
31 GO:1903305 regulation of regulated secretory pathway 1.216E-3 9.176E-3
5.537E-2
2.844E-1
 2 144
32 GO:0050904 diapedesis 1.503E-3 1.066E-2
6.431E-2
3.517E-1
 1 4
33 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase 1.503E-3 1.066E-2
6.431E-2
3.517E-1
 1 4
34 GO:0035426 extracellular matrix-cell signaling 1.878E-3 1.217E-2
7.345E-2
4.395E-1
 1 5
35 GO:0032271 regulation of protein polymerization 1.952E-3 1.217E-2
7.345E-2
4.569E-1
 2 183
36 GO:0002274 myeloid leukocyte activation 1.952E-3 1.217E-2
7.345E-2
4.569E-1
 2 183
37 GO:0002703 regulation of leukocyte mediated immunity 1.974E-3 1.217E-2
7.345E-2
4.618E-1
 2 184
38 GO:0002699 positive regulation of immune effector process 1.995E-3 1.217E-2
7.345E-2
4.668E-1
 2 185
39 GO:0007259 JAK-STAT cascade 2.081E-3 1.217E-2
7.345E-2
4.869E-1
 2 189
40 GO:0097696 STAT cascade 2.081E-3 1.217E-2
7.345E-2
4.869E-1
 2 189
41 GO:0051495 positive regulation of cytoskeleton organization 2.213E-3 1.263E-2
7.621E-2
5.178E-1
 2 195
42 GO:0017157 regulation of exocytosis 2.442E-3 1.360E-2
8.210E-2
5.714E-1
 2 205
43 GO:0033007 negative regulation of mast cell activation involved in immune response 3.004E-3 1.601E-2
9.659E-2
7.029E-1
 1 8
44 GO:0031334 positive regulation of protein complex assembly 3.010E-3 1.601E-2
9.659E-2
7.042E-1
 2 228
45 GO:0002366 leukocyte activation involved in immune response 3.194E-3 1.652E-2
9.968E-2
7.473E-1
 2 235
46 GO:0002263 cell activation involved in immune response 3.247E-3 1.652E-2
9.968E-2
7.598E-1
 2 237
47 GO:0051258 protein polymerization 3.410E-3 1.698E-2
1.025E-1
7.980E-1
 2 243
48 GO:0036005 response to macrophage colony-stimulating factor 3.753E-3 1.792E-2
1.082E-1
8.783E-1
 1 10
49 GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 3.753E-3 1.792E-2
1.082E-1
8.783E-1
 1 10
50 GO:0070102 interleukin-6-mediated signaling pathway 4.128E-3 1.894E-2
1.143E-1
9.660E-1
 1 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 1.056E-10 2.323E-9 8.573E-9 2.323E-9 5 107
2 GO:0019897 extrinsic component of plasma membrane 6.259E-10 6.884E-9 2.541E-8 1.377E-8 5 152
3 GO:0009898 cytoplasmic side of plasma membrane 1.069E-9 7.839E-9 2.893E-8 2.352E-8 5 169
4 GO:0098562 cytoplasmic side of membrane 1.641E-9 9.027E-9 3.332E-8 3.611E-8 5 184
5 GO:0019898 extrinsic component of membrane 1.306E-8 5.745E-8 2.120E-7 2.872E-7 5 278
6 GO:0097381 photoreceptor disc membrane 6.958E-3 2.551E-2
9.416E-2
1.531E-1
 1 19
7 GO:0031252 cell leading edge 8.151E-3 2.562E-2
9.455E-2
1.793E-1
 2 389
Show 2 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 125 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 133 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003749 down-turned corners of mouth 6.760E-4 4.495E-2
2.460E-1
8.991E-2
 1 1
2 MP:0030192 downturned snout 6.760E-4 4.495E-2
2.460E-1
8.991E-2
 1 1

6: Domain [Display Chart] 7 input genes in category / 39 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00017 SH2 Pfam 1.472E-13 2.166E-12 9.214E-12 5.740E-12 6 101
2 SM00252 SH2 SMART 2.486E-13 2.166E-12 9.214E-12 9.697E-12 6 110
3 PS50001 SH2 PROSITE 2.628E-13 2.166E-12 9.214E-12 1.025E-11 6 111
4 3.30.505.10 - Gene3D 2.777E-13 2.166E-12 9.214E-12 1.083E-11 6 112
5 IPR000980 SH2 InterPro 2.777E-13 2.166E-12 9.214E-12 1.083E-11 6 112
6 IPR020635 Tyr kinase cat dom InterPro 4.248E-11 2.367E-10 1.007E-9 1.657E-9 5 88
7 SM00219 TyrKc SMART 4.248E-11 2.367E-10 1.007E-9 1.657E-9 5 88
8 IPR008266 Tyr kinase AS InterPro 6.982E-11 3.026E-10 1.287E-9 2.723E-9 5 97
9 PS00109 PROTEIN KINASE TYR PROSITE 6.982E-11 3.026E-10 1.287E-9 2.723E-9 5 97
10 PF07714 Pkinase Tyr Pfam 2.973E-10 1.160E-9 4.933E-9 1.160E-8 5 129
11 IPR001245 Ser-Thr/Tyr kinase cat dom InterPro 4.184E-10 1.483E-9 6.310E-9 1.632E-8 5 138
12 IPR017441 Protein kinase ATP BS InterPro 6.704E-8 2.179E-7 9.267E-7 2.614E-6 5 379
13 IPR016250 Tyr-prot kinase Fes/Fps InterPro 1.197E-7 3.590E-7 1.527E-6 4.667E-6 2 2
14 PS00107 PROTEIN KINASE ATP PROSITE 1.742E-7 4.853E-7 2.064E-6 6.794E-6 5 459
15 IPR000719 Prot kinase dom InterPro 2.387E-7 6.060E-7 2.578E-6 9.311E-6 5 489
16 PS50011 PROTEIN KINASE DOM PROSITE 2.486E-7 6.060E-7 2.578E-6 9.696E-6 5 493
17 PF00018 SH3 1 Pfam 2.246E-5 5.154E-5 2.192E-4 8.761E-4 3 164
18 PF00611 FCH Pfam 2.754E-5 5.654E-5 2.405E-4 1.074E-3 2 22
19 SM00055 FCH SMART 2.754E-5 5.654E-5 2.405E-4 1.074E-3 2 22
20 IPR001060 FCH dom InterPro 3.016E-5 5.882E-5 2.502E-4 1.176E-3 2 23
21 IPR031160 F BAR InterPro 3.575E-5 6.338E-5 2.696E-4 1.394E-3 2 25
22 PS51741 F BAR PROSITE 3.575E-5 6.338E-5 2.696E-4 1.394E-3 2 25
23 SM00326 SH3 SMART 5.183E-5 8.423E-5 3.583E-4 2.021E-3 3 217
24 PS50002 SH3 PROSITE 5.183E-5 8.423E-5 3.583E-4 2.021E-3 3 217
25 IPR001452 SH3 domain InterPro 5.473E-5 8.538E-5 3.632E-4 2.134E-3 3 221
26 IPR028539 Fer InterPro 3.736E-4 5.397E-4 2.296E-3 1.457E-2 1 1
27 IPR028849 BCAR3 InterPro 3.736E-4 5.397E-4 2.296E-3 1.457E-2 1 1
28 IPR006952 PDE6 gamma InterPro 7.471E-4 9.713E-4 4.131E-3 2.914E-2 1 2
29 4.10.1120.10 - Gene3D 7.471E-4 9.713E-4 4.131E-3 2.914E-2 1 2
30 PF04868 PDE6 gamma Pfam 7.471E-4 9.713E-4 4.131E-3 2.914E-2 1 2
31 PS00720 RASGEF PROSITE 9.676E-3 1.176E-2
5.002E-2
3.773E-1
 1 26
32 PS50009 RASGEF CAT PROSITE 1.079E-2 1.176E-2
5.002E-2
4.207E-1
 1 29
33 SM00147 RasGEF SMART 1.116E-2 1.176E-2
5.002E-2
4.351E-1
 1 30
34 IPR001895 RASGEF cat dom InterPro 1.116E-2 1.176E-2
5.002E-2
4.351E-1
 1 30
35 IPR023578 Ras GEF dom InterPro 1.116E-2 1.176E-2
5.002E-2
4.351E-1
 1 30
36 1.10.840.10 - Gene3D 1.116E-2 1.176E-2
5.002E-2
4.351E-1
 1 30
37 PF00617 RasGEF Pfam 1.116E-2 1.176E-2
5.002E-2
4.351E-1
 1 30
38 PF07653 SH3 2 Pfam 3.206E-2 3.206E-2
1.364E-1
1.000E0
 1 87
39 IPR011511 SH3 2 InterPro 3.206E-2 3.206E-2
1.364E-1
1.000E0
 1 87
Show 34 more annotations

7: Pathway [Display Chart] 7 input genes in category / 62 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00007 Axon guidance mediated by semaphorins PantherDB 4.613E-5 2.860E-3 1.348E-2 2.860E-3 2 19
2 138017 Signaling events mediated by PTP1B BioSystems: Pathway Interaction Database 3.277E-4 7.903E-3 3.724E-2 2.032E-2 2 50
3 138071 PDGFR-beta signaling pathway BioSystems: Pathway Interaction Database 3.824E-4 7.903E-3 3.724E-2 2.371E-2 2 54
4 P00049 Parkinson disease PantherDB 9.909E-4 1.536E-2
7.238E-2
6.144E-2
 2 87
5 1383033 PTK6 Down-Regulation BioSystems: REACTOME 1.686E-3 1.899E-2
8.949E-2
1.045E-1
 1 3
6 1383027 PTK6 Activates STAT3 BioSystems: REACTOME 2.247E-3 1.899E-2
8.949E-2
1.393E-1
 1 4
7 1383026 PTK6 Expression BioSystems: REACTOME 2.809E-3 1.899E-2
8.949E-2
1.741E-1
 1 5
8 1383030 PTK6 Regulates Proteins Involved in RNA Processing BioSystems: REACTOME 2.809E-3 1.899E-2
8.949E-2
1.741E-1
 1 5
9 P00012 Cadherin signaling pathway PantherDB 3.263E-3 1.899E-2
8.949E-2
2.023E-1
 2 159
10 1383028 PTK6 Regulates Cell Cycle BioSystems: REACTOME 3.369E-3 1.899E-2
8.949E-2
2.089E-1
 1 6
11 1383032 PTK6 promotes HIF1A stabilization BioSystems: REACTOME 3.369E-3 1.899E-2
8.949E-2
2.089E-1
 1 6
12 1383031 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 BioSystems: REACTOME 5.050E-3 2.609E-2
1.230E-1
3.131E-1
 1 9
13 1269628 Activation of the phototransduction cascade BioSystems: REACTOME 6.170E-3 2.943E-2
1.387E-1
3.825E-1
 1 11
14 1383024 ERBB2 Activates PTK6 Signaling BioSystems: REACTOME 7.288E-3 3.228E-2
1.521E-1
4.519E-1
 1 13
15 1270308 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion BioSystems: REACTOME 8.405E-3 3.269E-2
1.541E-1
5.211E-1
 1 15
16 1270310 CRMPs in Sema3A signaling BioSystems: REACTOME 8.964E-3 3.269E-2
1.541E-1
5.557E-1
 1 16
17 1270309 Sema3A PAK dependent Axon repulsion BioSystems: REACTOME 8.964E-3 3.269E-2
1.541E-1
5.557E-1
 1 16
18 M16518 Wnt/Ca2+/cyclic GMP signaling. MSigDB C2 BIOCARTA (v6.0) 1.119E-2 3.856E-2
1.817E-1
6.940E-1
 1 20
19 138074 Visual signal transduction: Rods BioSystems: Pathway Interaction Database 1.286E-2 3.879E-2
1.828E-1
7.975E-1
 1 23
20 1269487 Signaling by SCF-KIT BioSystems: REACTOME 1.426E-2 3.879E-2
1.828E-1
8.841E-1
 2 340
21 138010 Glypican 1 network BioSystems: Pathway Interaction Database 1.453E-2 3.879E-2
1.828E-1
9.009E-1
 1 26
22 137964 Regulation of p38-alpha and p38-beta BioSystems: Pathway Interaction Database 1.509E-2 3.879E-2
1.828E-1
9.353E-1
 1 27
23 138052 Ephrin B reverse signaling BioSystems: Pathway Interaction Database 1.509E-2 3.879E-2
1.828E-1
9.353E-1
 1 27
24 149806 Phototransduction BioSystems: KEGG 1.564E-2 3.879E-2
1.828E-1
9.697E-1
 1 28
25 1383029 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases BioSystems: REACTOME 1.564E-2 3.879E-2
1.828E-1
9.697E-1
 1 28
26 137990 Regulation of CDC42 activity BioSystems: Pathway Interaction Database 1.675E-2 3.889E-2
1.833E-1
1.000E0
 1 30
27 138041 EPHA forward signaling BioSystems: Pathway Interaction Database 1.730E-2 3.889E-2
1.833E-1
1.000E0
 1 31
28 137913 Alpha-synuclein signaling BioSystems: Pathway Interaction Database 1.786E-2 3.889E-2
1.833E-1
1.000E0
 1 32
29 137919 N-cadherin signaling events BioSystems: Pathway Interaction Database 1.841E-2 3.889E-2
1.833E-1
1.000E0
 1 33
30 P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction PantherDB 1.952E-2 3.889E-2
1.833E-1
1.000E0
 1 35
31 1269629 Inactivation, recovery and regulation of the phototransduction cascade BioSystems: REACTOME 1.952E-2 3.889E-2
1.833E-1
1.000E0
 1 35
32 1269627 The phototransduction cascade BioSystems: REACTOME 2.007E-2 3.889E-2
1.833E-1
1.000E0
 1 36
33 138022 Class I PI3K signaling events BioSystems: Pathway Interaction Database 2.283E-2 4.289E-2
2.021E-1
1.000E0
 1 41
34 PW:0000031 purine metabolic Pathway Ontology 2.393E-2 4.311E-2
2.032E-1
1.000E0
 1 43
35 1269184 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers BioSystems: REACTOME 2.448E-2 4.311E-2
2.032E-1
1.000E0
 1 44
36 138060 Thromboxane A2 receptor signaling BioSystems: Pathway Interaction Database 2.503E-2 4.311E-2
2.032E-1
1.000E0
 1 45
37 137917 Angiopoietin receptor Tie2-mediated signaling BioSystems: Pathway Interaction Database 2.668E-2 4.354E-2
2.052E-1
1.000E0
 1 48
38 137945 amb2 Integrin signaling BioSystems: Pathway Interaction Database 2.668E-2 4.354E-2
2.052E-1
1.000E0
 1 48
39 1269489 Signaling by ERBB2 BioSystems: REACTOME 2.833E-2 4.476E-2
2.109E-1
1.000E0
 1 51
40 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 2.888E-2 4.476E-2
2.109E-1
1.000E0
 1 52
41 138050 Fc-epsilon receptor I signaling in mast cells BioSystems: Pathway Interaction Database 3.271E-2 4.808E-2
2.266E-1
1.000E0
 1 59
42 1269615 Ca2+ pathway BioSystems: REACTOME 3.381E-2 4.808E-2
2.266E-1
1.000E0
 1 61
43 1269770 SCF(Skp2)-mediated degradation of p27/p21 BioSystems: REACTOME 3.490E-2 4.808E-2
2.266E-1
1.000E0
 1 63
44 137933 IL4-mediated signaling events BioSystems: Pathway Interaction Database 3.490E-2 4.808E-2
2.266E-1
1.000E0
 1 63
45 137940 Signaling events mediated by VEGFR1 and VEGFR2 BioSystems: Pathway Interaction Database 3.490E-2 4.808E-2
2.266E-1
1.000E0
 1 63
46 1270304 Semaphorin interactions BioSystems: REACTOME 3.762E-2 4.963E-2
2.339E-1
1.000E0
 1 68
47 1383025 Signaling by PTK6 BioSystems: REACTOME 3.762E-2 4.963E-2
2.339E-1
1.000E0
 1 68
Show 42 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 560 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11114734 The protein tyrosine kinase family of the human genome. Pubmed 2.389E-12 1.012E-9 6.990E-9 1.338E-9 5 83
2 16273093 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Pubmed 3.615E-12 1.012E-9 6.990E-9 2.024E-9 5 90
3 24728074 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. Pubmed 4.681E-10 8.737E-8 6.034E-7 2.621E-7 4 63
4 8943574 Expression of tyrosine kinase gene in mouse thymic stromal cells. Pubmed 7.233E-10 1.013E-7 6.993E-7 4.050E-7 3 10
5 22939624 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Pubmed 4.603E-9 5.156E-7 3.560E-6 2.578E-6 5 371
6 12901971 Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis. Pubmed 3.839E-8 2.389E-6 1.650E-5 2.150E-5 2 2
7 23355730 Fer kinase limits neutrophil chemotaxis toward end target chemoattractants. Pubmed 3.839E-8 2.389E-6 1.650E-5 2.150E-5 2 2
8 12871378 Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation. Pubmed 3.839E-8 2.389E-6 1.650E-5 2.150E-5 2 2
9 11994747 Closing in on the biological functions of Fps/Fes and Fer. Pubmed 3.839E-8 2.389E-6 1.650E-5 2.150E-5 2 2
10 12725532 Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. Pubmed 1.152E-7 5.863E-6 4.049E-5 6.449E-5 2 3
11 18053124 The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons. Pubmed 1.152E-7 5.863E-6 4.049E-5 6.449E-5 2 3
12 15322554 Control of vesicle fusion by a tyrosine phosphatase. Pubmed 5.756E-7 2.303E-5 1.590E-4 3.224E-4 2 6
13 16731527 Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. Pubmed 5.756E-7 2.303E-5 1.590E-4 3.224E-4 2 6
14 26702831 Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis. Pubmed 5.756E-7 2.303E-5 1.590E-4 3.224E-4 2 6
15 12192036 Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Pubmed 8.058E-7 3.008E-5 2.078E-4 4.512E-4 2 7
16 8247543 A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. Pubmed 2.110E-6 7.383E-5 5.099E-4 1.181E-3 2 11
17 15254900 Identification of tyrosine kinases expressed in the male mouse gubernaculum during development. Pubmed 1.057E-5 3.482E-4 2.405E-3 5.920E-3 2 24
18 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 6.186E-5 5.013E-4 3.462E-3 3.464E-2 3 401
19 15951569 Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Pubmed 1.057E-4 5.013E-4 3.462E-3
5.921E-2
 2 75
20 12358933 Familial transient erythroblastopenia of childhood is associated with the chromosome 19q13.2 region but not caused by mutations in coding sequences of the ribosomal protein S19 (RPS19) gene. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
21 25940761 Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
22 9284935 Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
23 11994443 Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
24 12569567 Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
25 25972485 Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
26 20030920 [Expression of c-fes gene in leukemia cells and its clinical significance]. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
27 21920434 Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
28 8880875 Genetic mechanisms of estrogen-independence in breast cancer. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
29 19401189 Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
30 7523858 The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
31 20111072 FES kinases are required for oncogenic FLT3 signaling. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
32 7136690 Transient erythroblastopenia in siblings. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
33 24788754 PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
34 20397626 Determinants for phosphodiesterase 6 inhibition by its gamma-subunit. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
35 27665472 Fyn-related kinase expression predicts favorable prognosis in patients with cervical cancer and suppresses malignant progression by regulating migration and invasion. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
36 8373729 ferT encodes a meiosis-specific nuclear tyrosine kinase. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
37 25499443 Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
38 21268181 Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
39 18781181 Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
40 19667185 Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
41 7700650 Human c-FES is a nuclear tyrosine kinase. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
42 22989419 Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
43 22705009 Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
44 12972546 Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
45 19732771 fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
46 23699534 Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
47 9749526 Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
48 15929003 Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
49 27864698 BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares. Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
50 2209086 The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Pubmed 2.095E-4 5.013E-4 3.462E-3
1.173E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 174 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ERBB2 ERBB2 interactions 1.294E-6 2.251E-4 1.292E-3 2.251E-4 4 249
2 int:IRS1 IRS1 interactions 6.582E-6 5.727E-4 3.287E-3 1.145E-3 3 103
3 int:ERBB3 ERBB3 interactions 4.459E-5 2.586E-3 1.484E-2 7.758E-3 3 195
4 int:STAT3 STAT3 interactions 1.635E-4 6.366E-3 3.653E-2 2.845E-2 3 302
5 int:DOK1 DOK1 interactions 1.829E-4 6.366E-3 3.653E-2 3.183E-2 2 53
6 int:BCAR1 BCAR1 interactions 4.600E-4 1.334E-2
7.657E-2
8.005E-2
 2 84
7 int:BCR BCR interactions 6.513E-4 1.417E-2
8.130E-2
1.133E-1
 2 100
8 int:NSF NSF interactions 6.513E-4 1.417E-2
8.130E-2
1.133E-1
 2 100
9 int:CCDC33 CCDC33 interactions 7.873E-4 1.522E-2
8.735E-2
1.370E-1
 2 110
10 int:JAK1 JAK1 interactions 9.671E-4 1.683E-2
9.658E-2
1.683E-1
 2 122
11 int:DNM2 DNM2 interactions 1.253E-3 1.981E-2
1.137E-1
2.180E-1
 2 139
12 int:KCTD4 KCTD4 interactions 1.976E-3 2.865E-2
1.644E-1
3.438E-1
 1 5
13 int:LINC01139 LINC01139 interactions 2.370E-3 3.007E-2
1.726E-1
4.125E-1
 1 6
14 int:KHDRBS1 KHDRBS1 interactions 2.420E-3 3.007E-2
1.726E-1
4.210E-1
 2 194
15 int:ZNF775 ZNF775 interactions 3.160E-3 3.337E-2
1.915E-1
5.498E-1
 1 8
16 int:CYTIP CYTIP interactions 3.554E-3 3.337E-2
1.915E-1
6.184E-1
 1 9
17 int:ANKRD54 ANKRD54 interactions 3.554E-3 3.337E-2
1.915E-1
6.184E-1
 1 9
18 int:SCGB1A1 SCGB1A1 interactions 3.554E-3 3.337E-2
1.915E-1
6.184E-1
 1 9
19 int:SYCP3 SYCP3 interactions 3.948E-3 3.337E-2
1.915E-1
6.870E-1
 1 10
20 int:PIK3R1 PIK3R1 interactions 4.012E-3 3.337E-2
1.915E-1
6.981E-1
 2 251
21 int:PDE6G PDE6G interactions 4.342E-3 3.337E-2
1.915E-1
7.555E-1
 1 11
22 int:FRK FRK interactions 4.342E-3 3.337E-2
1.915E-1
7.555E-1
 1 11
23 int:HOXC6 HOXC6 interactions 4.736E-3 3.337E-2
1.915E-1
8.241E-1
 1 12
24 int:FAM217B FAM217B interactions 4.736E-3 3.337E-2
1.915E-1
8.241E-1
 1 12
25 int:HSH2D HSH2D interactions 5.130E-3 3.337E-2
1.915E-1
8.926E-1
 1 13
26 int:RNASE3 RNASE3 interactions 5.524E-3 3.337E-2
1.915E-1
9.611E-1
 1 14
27 int:RASA3 RASA3 interactions 5.524E-3 3.337E-2
1.915E-1
9.611E-1
 1 14
28 int:AGR3 AGR3 interactions 5.917E-3 3.337E-2
1.915E-1
1.000E0
 1 15
29 int:GAST GAST interactions 5.917E-3 3.337E-2
1.915E-1
1.000E0
 1 15
30 int:GREB1 GREB1 interactions 6.311E-3 3.337E-2
1.915E-1
1.000E0
 1 16
31 int:CASZ1 CASZ1 interactions 6.311E-3 3.337E-2
1.915E-1
1.000E0
 1 16
32 int:GLCE GLCE interactions 6.704E-3 3.337E-2
1.915E-1
1.000E0
 1 17
33 int:PDLIM2 PDLIM2 interactions 6.704E-3 3.337E-2
1.915E-1
1.000E0
 1 17
34 int:EPSTI1 EPSTI1 interactions 7.097E-3 3.337E-2
1.915E-1
1.000E0
 1 18
35 int:STAP2 STAP2 interactions 7.097E-3 3.337E-2
1.915E-1
1.000E0
 1 18
36 int:ARC ARC interactions 7.097E-3 3.337E-2
1.915E-1
1.000E0
 1 18
37 int:BEX1 BEX1 interactions 7.097E-3 3.337E-2
1.915E-1
1.000E0
 1 18
38 int:FCGR2B FCGR2B interactions 7.490E-3 3.430E-2
1.968E-1
1.000E0
 1 19
39 int:BNIP2 BNIP2 interactions 7.883E-3 3.517E-2
2.018E-1
1.000E0
 1 20
40 int:A4GNT A4GNT interactions 8.276E-3 3.569E-2
2.048E-1
1.000E0
 1 21
41 int:ATP5IF1 ATP5IF1 interactions 8.668E-3 3.569E-2
2.048E-1
1.000E0
 1 22
42 int:SLC30A4 SLC30A4 interactions 9.061E-3 3.569E-2
2.048E-1
1.000E0
 1 23
43 int:THRSP THRSP interactions 9.061E-3 3.569E-2
2.048E-1
1.000E0
 1 23
44 int:TMF1 TMF1 interactions 9.061E-3 3.569E-2
2.048E-1
1.000E0
 1 23
45 int:PSMC3IP PSMC3IP interactions 9.453E-3 3.569E-2
2.048E-1
1.000E0
 1 24
46 int:EFS EFS interactions 9.453E-3 3.569E-2
2.048E-1
1.000E0
 1 24
47 int:DPYSL5 DPYSL5 interactions 9.845E-3 3.569E-2
2.048E-1
1.000E0
 1 25
48 int:ATAD2 ATAD2 interactions 9.845E-3 3.569E-2
2.048E-1
1.000E0
 1 25
49 int:APBB3 APBB3 interactions 1.024E-2 3.603E-2
2.068E-1
1.000E0
 1 26
50 int:PTK6 PTK6 interactions 1.063E-2 3.603E-2
2.068E-1
1.000E0
 1 27
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q21-q22.3 6q21-q22.3 2.308E-4 1.846E-3 5.018E-3 1.846E-3 1 1
2 8p23-p22 8p23-p22 1.154E-3 4.614E-3 1.254E-2 9.229E-3 1 5
3 5q21 5q21 2.767E-3 7.378E-3 2.005E-2 2.213E-2 1 12
4 20q13.3 20q13.3 4.607E-3 9.215E-3 2.504E-2 3.686E-2 1 20
5 1p22.1 1p22.1 8.051E-3 1.196E-2 3.249E-2
6.440E-2
 1 35
6 17q25 17q25 8.967E-3 1.196E-2 3.249E-2
7.174E-2
 1 39
7 15q26.1 15q26.1 1.422E-2 1.625E-2 4.418E-2
1.138E-1
 1 62
8 19q13.2 19q13.2 3.835E-2 3.835E-2
1.042E-1
3.068E-1
 1 169
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 51 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 741 SH2 domain containing genenames.org 1.755E-13 7.018E-13 1.462E-12 7.018E-13 6 101
2 1288 F-BAR domain containing genenames.org 3.198E-5 6.396E-5 1.332E-4 1.279E-4 2 23
3 681 Phosphodiesterases genenames.org 9.199E-3 1.227E-2 2.555E-2 3.680E-2 1 24

13: Coexpression [Display Chart] 8 input genes in category / 650 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 4.238E-10 2.755E-7 1.943E-6 2.755E-7 6 368
2 M470 Genes down-regulated in RAW264.7 cells (macrophage): control versus stimulated with IFN-b. MSigDB C7: Immunologic Signatures (v6.0) 6.380E-4 4.843E-2
3.417E-1
4.147E-1
 2 112
3 M6498 Genes up-regulated in monocyte-derived dendritic cells: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.095E-3 4.843E-2
3.417E-1
7.116E-1
 2 147
4 M8926 Genes down-regulated in CD4 [GeneID=920] T cells: naïve versus Th1. MSigDB C7: Immunologic Signatures (v6.0) 1.360E-3 4.843E-2
3.417E-1
8.838E-1
 2 164
5 M8188 Genes down-regulated in double positive thymocytes: wildtype versus over-expressing HDAC7[GeneID=51564] fused with VP16. MSigDB C7: Immunologic Signatures (v6.0) 1.409E-3 4.843E-2
3.417E-1
9.160E-1
 2 167
6 M8186 Genes up-regulated in B lymphocytes after immunization with: monophosphoryl lipid A versus imiquimod [PubChem=13982876]. MSigDB C7: Immunologic Signatures (v6.0) 1.477E-3 4.843E-2
3.417E-1
9.599E-1
 2 171
7 M7931 Genes down-regulated in bone marrow-derived macrophages with STAT6 [GeneID=6778] knockout: control versus treated with IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.875E-3 4.843E-2
3.417E-1
1.000E0
 2 193
8 M9977 Genes down-regulated during primary acute viral infection in ITGAM+ [GeneID=3684] dendritic cells: wildtype versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.894E-3 4.843E-2
3.417E-1
1.000E0
 2 194
9 M7701 Genes down-regulated in CD4 [GeneID=920] T cells: control versus tretinoin [PubChem=444795]. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 4.843E-2
3.417E-1
1.000E0
 2 198
10 M5439 Genes down-regulated in comparison of mast cells versus basophils. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 4.843E-2
3.417E-1
1.000E0
 2 199
11 M9651 Genes down-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 60h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 4.843E-2
3.417E-1
1.000E0
 2 199
12 M4476 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
13 M6547 Genes up-regulated in activated macrophages: classically (M1) versus alternative (M2). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
14 M5983 Genes down-regulated in liver with knockouts of: SOCS3 [GeneID=9021] versus IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
15 M5421 Genes down-regulated in comparison of eosinophils versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
16 M3025 Genes down-regulated in comparison of effector CD8 T cells at the peak expansion phase (day8) versus those at contraction (day 15) after LCMV-Armstrong infection. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
17 M7153 Genes up-regulated in CD4 [GeneID=920] T cells versus follicular helper CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
18 M6419 Genes down-regulated in monocytes (12h): untreated versus M. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
19 M7212 Genes down-regulated in mouse embryonic fibroblasts (MEF): control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
20 M9328 Genes down-regulated in day 7 germinal center B cells versus day 40 memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
21 M5185 Genes up-regulated in comparison of dendritic cells (DC) exposed to 50 worm/well B. malayi versus macrophages exposed to 50 worms/well B. malayi. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
22 M6617 Genes down-regulated in bone marrow-derived macrophage (180 min): LPS versus IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
23 M3675 Genes up-regulated in comparison of T effector cells from uninfected mice versus T effector cells from mice infected with S. mansoni. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
24 M9204 Genes down-regulated in CD8 T cells: naïve versus day 8 after LCMV infection. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
25 M8842 Genes down-regulated in multipotent progenitors versus common lymphoid progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
26 M6431 Genes down-regulated in CD4 [GeneID=920] T cells versus NKT cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
27 M5834 Genes down-regulated in comparison of effector CD8 T cells versus exhausted CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.843E-2
3.417E-1
1.000E0
 2 200
Show 22 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 463 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM538230 100 B cells, B1b.PC, IgD+ IgM+ CD19+ CD43+ CD5+ CD45R+, Peritoneal Cavity, avg-1 Immgen.org, GSE15907 9.062E-5 3.978E-3 2.671E-2 4.196E-2 2 46
2 GSM538225 100 B cells, B1a.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23- CD21/35-, Spleen, avg-3 Immgen.org, GSE15907 9.062E-5 3.978E-3 2.671E-2 4.196E-2 2 46
3 GSM538228 100 B cells, B1b.PC, IgD+ IgM+ CD19+ CD43+ CD5- CD45R+, Peritoneal Cavity, avg-2 Immgen.org, GSE15907 9.873E-5 3.978E-3 2.671E-2 4.571E-2 2 48
4 GSM538222 100 B cells, B1a.PC, IgD+ IgM+ CD19+ CD43+ CD5+ CD45R+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.029E-4 3.978E-3 2.671E-2 4.765E-2 2 49
5 GSM854229 100 B cells, B1a.Sp, CD19+ CD45R+ IgM++ AA4.1- CD23- CD43+ CD5+, Spleen, avg-3 Immgen.org, GSE15907 1.029E-4 3.978E-3 2.671E-2 4.765E-2 2 49
6 GSM538198 100 B cells, B.Fo.PC, IgD+ IgM+ CD19+ CD43- CD5- CD23+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.205E-4 3.978E-3 2.671E-2
5.580E-2
 2 53
7 GSM777021 100 B cells, B.Fo.MLN, CD19+ CD45R+ CD23+ CD21/35+, Lymph Node, avg-3 Immgen.org, GSE15907 1.205E-4 3.978E-3 2.671E-2
5.580E-2
 2 53
8 GSM538213 100 B cells, B.T1.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23-, Spleen, avg-3 Immgen.org, GSE15907 1.251E-4 3.978E-3 2.671E-2
5.794E-2
 2 54
9 GSM403988 100 CD positive, CD19 Control, 19+ 4- 8-, Spleen, avg-6 Immgen.org, GSE15907 1.251E-4 3.978E-3 2.671E-2
5.794E-2
 2 54
10 GSM538207 100 B cells, B.GC.Sp, CD19+ IgM+ IgD- GL7+ PNA+, Spleen, avg-3 Immgen.org, GSE15907 1.251E-4 3.978E-3 2.671E-2
5.794E-2
 2 54
11 GSM538216 100 B cells, B.T2.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23+, Spleen, avg-3 Immgen.org, GSE15907 1.251E-4 3.978E-3 2.671E-2
5.794E-2
 2 54
12 GSM538201 100 B cells, B.Fo.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23+, Spleen, avg-3 Immgen.org, GSE15907 1.298E-4 3.978E-3 2.671E-2
6.012E-2
 2 55
13 GSM538219 100 B cells, B.T3.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23+, Spleen, avg-3 Immgen.org, GSE15907 1.346E-4 3.978E-3 2.671E-2
6.233E-2
 2 56
14 GSM399440 100 B cells, B.FrF.BM, CD19+ IgM+ AA4.1- HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 1.445E-4 3.978E-3 2.671E-2
6.689E-2
 2 58
15 GSM538211 100 B cells, B.MZ.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23- CD21/35+, Spleen, avg-2 Immgen.org, GSE15907 1.445E-4 3.978E-3 2.671E-2
6.689E-2
 2 58
16 GSM538210 100 B cells, B.MZ.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23- CD21.35+, Spleen, avg-1 Immgen.org, GSE15907 1.445E-4 3.978E-3 2.671E-2
6.689E-2
 2 58
17 GSM399438 100 B cells, B.FrE.BM, CD19+ IgM+ AA4.1+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 1.495E-4 3.978E-3 2.671E-2
6.922E-2
 2 59
18 GSM538204 100 B cells, B.FrE.FL, AA4.1+ IgM+ CD19+ CD43- CD24+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.546E-4 3.978E-3 2.671E-2
7.160E-2
 2 60
19 Sample Type by Project: Shred 1/TCGA-Cervix/Endocervical Adenocarcinoma/Mucinous Adenocarcinoma/3 Sample Type by Project: Shred 1/TCGA-Cervix/Endocervical Adenocarcinoma/Mucinous Adenocarcinoma/3 TCGA-Cervix 2.047E-4 4.988E-3 3.350E-2
9.477E-2
 2 69
20 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/2/1 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/2/1 TCGA-Esophagus 9.886E-4 2.289E-2
1.537E-1
4.577E-1
 2 152
21 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup7 Excitatory.subGroup7 Subtype Excitatory.subGroup7 Cerebellum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup7 Excitatory.subGroup7 Subtype Excitatory.subGroup7 Cerebellum Top 200 Genes BrainMap 1.412E-3 3.114E-2
2.091E-1
6.540E-1
 2 182
Show 16 more annotations

15: Computational [Display Chart] 6 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M18786 MODULE 248 Genes in the cancer module 248. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.033E-5 1.008E-3 3.847E-3 1.008E-3 3 129

16: MicroRNA [Display Chart] 8 input genes in category / 278 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-454-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.830E-5 5.088E-3 3.158E-2 5.088E-3 2 59
2 hsa-miR-3680-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.674E-4 1.120E-2
6.951E-2
 4.654E-2 2 178
3 hsa-miR-507:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-4 1.120E-2
6.951E-2
5.190E-2
 2 188
4 hsa-miR-557:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-4 1.120E-2
6.951E-2
5.190E-2
 2 188
5 hsa-miR-450b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.176E-4 1.120E-2
6.951E-2
6.049E-2
 2 203
6 hsa-miR-1237:PITA hsa-miR-1237:PITA TOP PITA 2.417E-4 1.120E-2
6.951E-2
6.719E-2
 2 214
7 hsa-miR-191*:mirSVR highEffct hsa-miR-191*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.987E-4 1.186E-2
7.363E-2
8.304E-2
 2 238
8 hsa-miR-4301:mirSVR highEffct hsa-miR-4301:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.211E-4 2.736E-2
1.698E-1
2.283E-1
 2 396
9 hsa-miR-369-5p:PITA hsa-miR-369-5p:PITA TOP PITA 8.856E-4 2.736E-2
1.698E-1
2.462E-1
 1 8
10 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.216E-3 3.124E-2
1.939E-1
3.381E-1
 2 483
11 hsa-miR-7160-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.236E-3 3.124E-2
1.939E-1
3.437E-1
 2 487
12 hsa-miR-4661-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.213E-3 3.893E-2
2.416E-1
6.152E-1
 1 20
13 hsa-miR-191-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.765E-3 3.893E-2
2.416E-1
7.688E-1
 1 25
14 hsa-miR-3654:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.759E-3 3.893E-2
2.416E-1
1.000E0
 1 34
15 hsa-miR-4520-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.893E-2
2.416E-1
1.000E0
 1 35
16 hsa-miR-4694-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.893E-2
2.416E-1
1.000E0
 1 35
17 hsa-miR-4529-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 3.893E-2
2.416E-1
1.000E0
 1 36
18 hsa-miR-7975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.421E-3 3.893E-2
2.416E-1
1.000E0
 1 40
19 hsa-miR-1243:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.421E-3 3.893E-2
2.416E-1
1.000E0
 1 40
20 hsa-miR-490-5p:Functional MTI Functional MTI miRTarbase 4.532E-3 3.893E-2
2.416E-1
1.000E0
 1 41
21 hsa-miR-652-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.893E-2
2.416E-1
1.000E0
 1 42
22 hsa-miR-218-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.893E-2
2.416E-1
1.000E0
 1 42
23 hsa-miR-5191:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.893E-2
2.416E-1
1.000E0
 1 42
24 hsa-miR-6892-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.893E-2
2.416E-1
1.000E0
 1 42
25 hsa-miR-4728-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.193E-3 3.893E-2
2.416E-1
1.000E0
 1 47
26 hsa-miR-711:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.303E-3 3.893E-2
2.416E-1
1.000E0
 1 48
27 hsa-miR-5571-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.524E-3 3.893E-2
2.416E-1
1.000E0
 1 50
28 hsa-miR-503-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.524E-3 3.893E-2
2.416E-1
1.000E0
 1 50
29 hsa-miR-4686:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.893E-2
2.416E-1
1.000E0
 1 54
30 hsa-miR-582-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.075E-3 3.893E-2
2.416E-1
1.000E0
 1 55
31 hsa-miR-4520-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.893E-2
2.416E-1
1.000E0
 1 56
32 hsa-miR-6883-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.295E-3 3.893E-2
2.416E-1
1.000E0
 1 57
33 hsa-miR-1261:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.405E-3 3.893E-2
2.416E-1
1.000E0
 1 58
34 hsa-miR-26a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.515E-3 3.893E-2
2.416E-1
1.000E0
 1 59
35 hsa-miR-4529-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.736E-3 3.893E-2
2.416E-1
1.000E0
 1 61
36 hsa-miR-103b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.736E-3 3.893E-2
2.416E-1
1.000E0
 1 61
37 hsa-miR-3147:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.846E-3 3.893E-2
2.416E-1
1.000E0
 1 62
38 hsa-miR-5682:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.066E-3 3.893E-2
2.416E-1
1.000E0
 1 64
39 hsa-miR-3938:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.176E-3 3.893E-2
2.416E-1
1.000E0
 1 65
40 hsa-miR-6071:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.176E-3 3.893E-2
2.416E-1
1.000E0
 1 65
41 hsa-miR-6882-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.616E-3 3.893E-2
2.416E-1
1.000E0
 1 69
42 hsa-miR-942-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.616E-3 3.893E-2
2.416E-1
1.000E0
 1 69
43 hsa-miR-3974:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.616E-3 3.893E-2
2.416E-1
1.000E0
 1 69
44 hsa-miR-3692-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.946E-3 3.893E-2
2.416E-1
1.000E0
 1 72
45 hsa-miR-4326:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.946E-3 3.893E-2
2.416E-1
1.000E0
 1 72
46 hsa-miR-8077:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.386E-3 3.893E-2
2.416E-1
1.000E0
 1 76
47 hsa-miR-1201:PITA hsa-miR-1201:PITA TOP PITA 8.496E-3 3.893E-2
2.416E-1
1.000E0
 1 77
48 hsa-miR-151a-3p:TargetScan hsa-miR-151a-3p TargetScan 8.496E-3 3.893E-2
2.416E-1
1.000E0
 1 77
49 hsa-miR-4732-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.606E-3 3.893E-2
2.416E-1
1.000E0
 1 78
50 hsa-miR-3688-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.716E-3 3.893E-2
2.416E-1
1.000E0
 1 79
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1684 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C545373 ponatinib CTD 8.758E-7 1.475E-3 1.181E-2 1.475E-3 3 68
2 CID000005291 imatinib Stitch 4.145E-6 3.490E-3 2.794E-2 6.980E-3 4 430
3 CID000139654 silver hydride Stitch 1.526E-5 8.564E-3
6.857E-2
 2.569E-2 2 20
4 7348 UP Fluticasone propionate [80474-14-2]; Up 200; 8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.222E-5 9.355E-3
7.490E-2
 3.742E-2 3 199
5 CID000016183 2,6-dichlorobenzamide Stitch 8.646E-5 2.912E-2
2.331E-1
1.456E-1
 2 47
6 CID006445562 EKB-569 Stitch 2.975E-4 3.438E-2
2.752E-1
5.009E-1
 2 87
7 ctd:C016601 afimoxifene CTD 3.013E-4 3.438E-2
2.752E-1
5.073E-1
 3 479
8 CID000009442 gamma-PCCH Stitch 3.065E-4 3.438E-2
2.752E-1
5.161E-1
 1 1
9 CID000011431 rubidium carbonate Stitch 3.065E-4 3.438E-2
2.752E-1
5.161E-1
 1 1
10 CID000199242 1,1-cyclohexanedithiol Stitch 3.065E-4 3.438E-2
2.752E-1
5.161E-1
 1 1
11 CID000014795 iron selenide Stitch 3.065E-4 3.438E-2
2.752E-1
5.161E-1
 1 1
12 CID003081361 vandetanib Stitch 3.850E-4 3.438E-2
2.752E-1
6.484E-1
 2 99
13 CID000010039 carbonyl sulfide Stitch 5.281E-4 3.438E-2
2.752E-1
8.894E-1
 2 116
14 CID000010721 o-tolunitrile Stitch 6.129E-4 3.438E-2
2.752E-1
1.000E0
 1 2
15 CID000129198 FESP Stitch 6.129E-4 3.438E-2
2.752E-1
1.000E0
 1 2
16 ctd:C507134 ON 01910 CTD 1.026E-3 3.438E-2
2.752E-1
1.000E0
 2 162
17 CID000003333 felodipine Stitch 1.115E-3 3.438E-2
2.752E-1
1.000E0
 2 169
18 4344 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.155E-3 3.438E-2
2.752E-1
1.000E0
 2 172
19 7068 DN MG-262; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.168E-3 3.438E-2
2.752E-1
1.000E0
 2 173
20 4237 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.168E-3 3.438E-2
2.752E-1
1.000E0
 2 173
21 6736 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.195E-3 3.438E-2
2.752E-1
1.000E0
 2 175
22 869 UP wortmannin; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 1.195E-3 3.438E-2
2.752E-1
1.000E0
 2 175
23 4072 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.195E-3 3.438E-2
2.752E-1
1.000E0
 2 175
24 CID006449882 Chl d cpd Stitch 1.225E-3 3.438E-2
2.752E-1
1.000E0
 1 4
25 CID000010567 1,1-DCA Stitch 1.225E-3 3.438E-2
2.752E-1
1.000E0
 1 4
26 CID000015290 cyclohexanethiol Stitch 1.225E-3 3.438E-2
2.752E-1
1.000E0
 1 4
27 CID000047032 SB12 Stitch 1.225E-3 3.438E-2
2.752E-1
1.000E0
 1 4
28 4483 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.250E-3 3.438E-2
2.752E-1
1.000E0
 2 179
29 6609 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.250E-3 3.438E-2
2.752E-1
1.000E0
 2 179
30 5511 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.264E-3 3.438E-2
2.752E-1
1.000E0
 2 180
31 3688 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.264E-3 3.438E-2
2.752E-1
1.000E0
 2 180
32 4662 UP Menadione [58-27-5]; Up 200; 23.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.278E-3 3.438E-2
2.752E-1
1.000E0
 2 181
33 1709 DN Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.306E-3 3.438E-2
2.752E-1
1.000E0
 2 183
34 6896 DN scriptaid; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.306E-3 3.438E-2
2.752E-1
1.000E0
 2 183
35 7339 UP Tracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.421E-3 3.438E-2
2.752E-1
1.000E0
 2 191
36 6659 DN Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.436E-3 3.438E-2
2.752E-1
1.000E0
 2 192
37 5218 UP Rapamycin; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.451E-3 3.438E-2
2.752E-1
1.000E0
 2 193
38 2828 DN Omeprazole [73590-58-6]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 3.438E-2
2.752E-1
1.000E0
 2 193
39 6685 UP Meglumine [6284-40-8]; Up 200; 20.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.465E-3 3.438E-2
2.752E-1
1.000E0
 2 194
40 7522 UP CP-645525-01 [287190-82-3]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.465E-3 3.438E-2
2.752E-1
1.000E0
 2 194
41 6242 UP Skimmianine [83-95-4]; Up 200; 15.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.465E-3 3.438E-2
2.752E-1
1.000E0
 2 194
42 7543 UP DNA-PK Inhibitor III; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.438E-2
2.752E-1
1.000E0
 2 195
43 4224 UP Benzocaine [94-09-7]; Up 200; 24.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.438E-2
2.752E-1
1.000E0
 2 195
44 7361 UP 3-Acetamidocoumarin [779-30-6]; Up 200; 19.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.480E-3 3.438E-2
2.752E-1
1.000E0
 2 195
45 4993 DN Estrone [53-16-7]; Down 200; 14.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 3.438E-2
2.752E-1
1.000E0
 2 196
46 4347 UP Nialamide [51-12-7]; Up 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.495E-3 3.438E-2
2.752E-1
1.000E0
 2 196
47 5005 DN Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 3.438E-2
2.752E-1
1.000E0
 2 196
48 7345 UP Alcuronium chloride [15180-03-7]; Up 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.495E-3 3.438E-2
2.752E-1
1.000E0
 2 196
49 2225 DN Nalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 3.438E-2
2.752E-1
1.000E0
 2 196
50 2868 DN Phenindione [83-12-5]; Down 200; 18uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.511E-3 3.438E-2
2.752E-1
1.000E0
 2 197
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 114 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C3150618 Maturity-onset diabetes of the young, type 11 Clinical Variations 4.937E-4 9.380E-3 4.988E-2
5.628E-2
 1 1
2 OMIN:613582 RETINITIS PIGMENTOSA 57; RP57 OMIM 4.937E-4 9.380E-3 4.988E-2
5.628E-2
 1 1
3 C3150618 Maturity-onset diabetes of the young, type 11 DisGeNET Curated 4.937E-4 9.380E-3 4.988E-2
5.628E-2
 1 1
4 cv:C3150821 Retinitis pigmentosa 57 Clinical Variations 4.937E-4 9.380E-3 4.988E-2
5.628E-2
 1 1
5 C3150821 RETINITIS PIGMENTOSA 57 DisGeNET Curated 4.937E-4 9.380E-3 4.988E-2
5.628E-2
 1 1
6 OMIN:613375 MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11; MODY11 OMIM 4.937E-4 9.380E-3 4.988E-2
5.628E-2
 1 1
7 C0238478 Transient erythroblastopenia of childhood DisGeNET BeFree 1.973E-3 2.812E-2
1.495E-1
2.250E-1
 1 4
8 20081125:Graham Systemic lupus erythematosus GWAS 1.973E-3 2.812E-2
1.495E-1
2.250E-1
 1 4
9 20090617:Gregersen Rheumatoid arthritis GWAS 2.959E-3 3.748E-2
1.993E-1
3.373E-1
 1 6
Show 4 more annotations