Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc38_24, positive side

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1: GO: Molecular Function [Display Chart] 24 input genes in category / 104 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004993 G protein-coupled serotonin receptor activity 6.063E-26 3.153E-24 1.648E-23 6.305E-24 10 18
2 GO:0099589 serotonin receptor activity 6.063E-26 3.153E-24 1.648E-23 6.305E-24 10 18
3 GO:0008227 G protein-coupled amine receptor activity 4.855E-23 1.683E-21 8.796E-21 5.049E-21 11 51
4 GO:0070405 ammonium ion binding 9.048E-21 2.352E-19 1.229E-18 9.410E-19 11 79
5 GO:0051378 serotonin binding 4.807E-16 9.416E-15 4.921E-14 4.999E-14 6 10
6 GO:0008144 drug binding 5.432E-16 9.416E-15 4.921E-14 5.650E-14 10 136
7 GO:0043176 amine binding 2.112E-15 3.137E-14 1.640E-13 2.196E-13 6 12
8 GO:0004952 dopamine neurotransmitter receptor activity 4.728E-14 6.146E-13 3.212E-12 4.917E-12 5 7
9 GO:0035240 dopamine binding 1.775E-12 2.052E-11 1.072E-10 1.846E-10 5 12
10 GO:0099528 G protein-coupled neurotransmitter receptor activity 4.480E-12 4.660E-11 2.435E-10 4.660E-10 5 14
11 GO:1901338 catecholamine binding 9.759E-12 9.226E-11 4.822E-10 1.015E-9 5 16
12 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs 3.150E-11 2.730E-10 1.427E-9 3.276E-9 4 6
13 GO:0030594 neurotransmitter receptor activity 2.613E-10 2.091E-9 1.093E-8 2.718E-8 6 69
14 GO:0001965 G-protein alpha-subunit binding 5.226E-10 3.882E-9 2.029E-8 5.435E-8 5 33
15 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go 1.869E-9 1.296E-8 6.773E-8 1.944E-7 3 3
16 GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 6.520E-8 4.238E-7 2.215E-6 6.780E-6 3 7
17 GO:0016247 channel regulator activity 8.091E-7 4.950E-6 2.587E-5 8.414E-5 5 139
18 GO:0001641 group II metabotropic glutamate receptor activity 1.585E-6 8.677E-6 4.535E-5 1.649E-4 2 2
19 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding 1.585E-6 8.677E-6 4.535E-5 1.649E-4 2 2
20 GO:0008066 glutamate receptor activity 5.357E-6 2.786E-5 1.456E-4 5.572E-4 3 27
21 GO:0005246 calcium channel regulator activity 1.531E-5 7.581E-5 3.962E-4 1.592E-3 3 38
22 GO:0004722 protein serine/threonine phosphatase activity 8.867E-5 4.192E-4 2.191E-3 9.222E-3 3 68
23 GO:0008157 protein phosphatase 1 binding 3.605E-4 1.562E-3 8.164E-3 3.749E-2 2 22
24 GO:0050780 dopamine receptor binding 3.605E-4 1.562E-3 8.164E-3 3.749E-2 2 22
25 GO:0019903 protein phosphatase binding 7.766E-4 3.231E-3 1.688E-2
8.076E-2
 3 142
26 GO:0010855 adenylate cyclase inhibitor activity 1.286E-3 4.612E-3 2.411E-2
1.338E-1
 1 1
27 GO:0010854 adenylate cyclase regulator activity 1.286E-3 4.612E-3 2.411E-2
1.338E-1
 1 1
28 GO:0001587 Gq/11-coupled serotonin receptor activity 1.286E-3 4.612E-3 2.411E-2
1.338E-1
 1 1
29 GO:0050115 myosin-light-chain-phosphatase activity 1.286E-3 4.612E-3 2.411E-2
1.338E-1
 1 1
30 GO:0019902 phosphatase binding 1.716E-3 5.786E-3 3.024E-2
1.785E-1
 3 187
31 GO:0015459 potassium channel regulator activity 1.725E-3 5.786E-3 3.024E-2
1.794E-1
 2 48
32 GO:0004721 phosphoprotein phosphatase activity 1.851E-3 6.015E-3 3.144E-2
1.925E-1
 3 192
33 GO:0070905 serine binding 3.854E-3 1.214E-2
6.347E-2
4.008E-1
 1 3
34 GO:0031750 D3 dopamine receptor binding 5.135E-3 1.483E-2
7.753E-2
5.340E-1
 1 4
35 GO:0001642 group III metabotropic glutamate receptor activity 5.135E-3 1.483E-2
7.753E-2
5.340E-1
 1 4
36 GO:0017018 myosin phosphatase activity 5.135E-3 1.483E-2
7.753E-2
5.340E-1
 1 4
37 GO:0016791 phosphatase activity 5.464E-3 1.536E-2
8.026E-2
5.682E-1
 3 282
38 GO:0004969 histamine receptor activity 7.693E-3 2.105E-2
1.100E-1
8.001E-1
 1 6
39 GO:0010851 cyclase regulator activity 1.152E-2 3.071E-2
1.605E-1
1.000E0
 1 9
40 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1.406E-2 3.567E-2
1.864E-1
1.000E0
 1 11
41 GO:0031748 D1 dopamine receptor binding 1.406E-2 3.567E-2
1.864E-1
1.000E0
 1 11
42 GO:0031701 angiotensin receptor binding 1.533E-2 3.796E-2
1.984E-1
1.000E0
 1 12
43 GO:0030676 Rac guanyl-nucleotide exchange factor activity 1.660E-2 3.923E-2
2.050E-1
1.000E0
 1 13
44 GO:0016595 glutamate binding 1.660E-2 3.923E-2
2.050E-1
1.000E0
 1 13
45 GO:0042578 phosphoric ester hydrolase activity 1.706E-2 3.944E-2
2.061E-1
1.000E0
 3 429
46 GO:0004935 adrenergic receptor activity 2.039E-2 4.610E-2
2.409E-1
1.000E0
 1 16
47 GO:0005521 lamin binding 2.165E-2 4.791E-2
2.504E-1
1.000E0
 1 17
Show 42 more annotations

2: GO: Biological Process [Display Chart] 24 input genes in category / 1062 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007210 serotonin receptor signaling pathway 6.188E-26 6.571E-23 4.958E-22 6.571E-23 10 18
2 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 5.654E-25 3.002E-22 2.266E-21 6.005E-22 15 184
3 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1.510E-21 5.345E-19 4.033E-18 1.604E-18 13 157
4 GO:0052652 cyclic purine nucleotide metabolic process 2.266E-17 5.172E-15 3.903E-14 2.406E-14 11 156
5 GO:0009190 cyclic nucleotide biosynthetic process 2.435E-17 5.172E-15 3.903E-14 2.586E-14 11 157
6 GO:0044070 regulation of anion transport 4.559E-17 8.070E-15 6.089E-14 4.842E-14 11 166
7 GO:0050804 modulation of chemical synaptic transmission 7.842E-17 1.190E-14 8.977E-14 8.328E-14 13 357
8 GO:0015696 ammonium transport 1.404E-16 1.864E-14 1.406E-13 1.491E-13 10 119
9 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1.860E-16 2.195E-14 1.656E-13 1.975E-13 9 74
10 GO:0050795 regulation of behavior 4.904E-16 4.930E-14 3.720E-13 5.208E-13 9 82
11 GO:0009187 cyclic nucleotide metabolic process 5.106E-16 4.930E-14 3.720E-13 5.423E-13 11 206
12 GO:0015844 monoamine transport 9.519E-16 8.424E-14 6.356E-13 1.011E-12 9 88
13 GO:0051952 regulation of amine transport 1.597E-15 1.304E-13 9.841E-13 1.696E-12 9 93
14 GO:0007270 neuron-neuron synaptic transmission 1.976E-15 1.499E-13 1.131E-12 2.099E-12 10 154
15 GO:0042220 response to cocaine 2.411E-15 1.707E-13 1.288E-12 2.561E-12 8 55
16 GO:0015837 amine transport 3.141E-15 2.085E-13 1.573E-12 3.336E-12 9 100
17 GO:0042310 vasoconstriction 3.777E-15 2.360E-13 1.780E-12 4.011E-12 9 102
18 GO:0009152 purine ribonucleotide biosynthetic process 5.454E-15 3.218E-13 2.428E-12 5.792E-12 11 255
19 GO:0006164 purine nucleotide biosynthetic process 7.053E-15 3.942E-13 2.975E-12 7.490E-12 11 261
20 GO:0009260 ribonucleotide biosynthetic process 9.447E-15 5.016E-13 3.785E-12 1.003E-11 11 268
21 GO:0046390 ribose phosphate biosynthetic process 1.112E-14 5.592E-13 4.219E-12 1.181E-11 11 272
22 GO:0072522 purine-containing compound biosynthetic process 1.158E-14 5.592E-13 4.219E-12 1.230E-11 11 273
23 GO:0006171 cAMP biosynthetic process 2.870E-14 1.302E-12 9.821E-12 3.048E-11 9 127
24 GO:0045761 regulation of adenylate cyclase activity 2.941E-14 1.302E-12 9.821E-12 3.124E-11 8 74
25 GO:0015872 dopamine transport 4.082E-14 1.734E-12 1.308E-11 4.335E-11 7 40
26 GO:0009165 nucleotide biosynthetic process 6.878E-14 2.669E-12 2.014E-11 7.305E-11 11 321
27 GO:0030809 negative regulation of nucleotide biosynthetic process 7.038E-14 2.669E-12 2.014E-11 7.474E-11 7 43
28 GO:1900372 negative regulation of purine nucleotide biosynthetic process 7.038E-14 2.669E-12 2.014E-11 7.474E-11 7 43
29 GO:1901293 nucleoside phosphate biosynthetic process 7.617E-14 2.789E-12 2.105E-11 8.089E-11 11 324
30 GO:1900542 regulation of purine nucleotide metabolic process 1.003E-13 3.550E-12 2.679E-11 1.065E-10 10 227
31 GO:0031279 regulation of cyclase activity 1.241E-13 4.252E-12 3.208E-11 1.318E-10 8 88
32 GO:1900371 regulation of purine nucleotide biosynthetic process 1.321E-13 4.383E-12 3.308E-11 1.403E-10 9 150
33 GO:0030808 regulation of nucleotide biosynthetic process 1.404E-13 4.435E-12 3.347E-11 1.491E-10 9 151
34 GO:0006140 regulation of nucleotide metabolic process 1.420E-13 4.435E-12 3.347E-11 1.508E-10 10 235
35 GO:0051339 regulation of lyase activity 1.494E-13 4.534E-12 3.422E-11 1.587E-10 8 90
36 GO:0043279 response to alkaloid 2.003E-13 5.909E-12 4.459E-11 2.127E-10 9 157
37 GO:0046058 cAMP metabolic process 2.520E-13 7.232E-12 5.457E-11 2.676E-10 9 161
38 GO:0007194 negative regulation of adenylate cyclase activity 4.053E-13 1.133E-11 8.547E-11 4.304E-10 6 25
39 GO:0050880 regulation of blood vessel size 5.381E-13 1.465E-11 1.106E-10 5.715E-10 9 175
40 GO:0035150 regulation of tube size 5.667E-13 1.505E-11 1.135E-10 6.018E-10 9 176
41 GO:0031280 negative regulation of cyclase activity 6.763E-13 1.752E-11 1.322E-10 7.183E-10 6 27
42 GO:0051966 regulation of synaptic transmission, glutamatergic 7.356E-13 1.860E-11 1.404E-10 7.812E-10 7 59
43 GO:0051350 negative regulation of lyase activity 1.084E-12 2.676E-11 2.019E-10 1.151E-9 6 29
44 GO:0042752 regulation of circadian rhythm 1.119E-12 2.700E-11 2.037E-10 1.188E-9 8 115
45 GO:0003018 vascular process in circulatory system 1.974E-12 4.660E-11 3.516E-10 2.097E-9 9 202
46 GO:1900543 negative regulation of purine nucleotide metabolic process 2.075E-12 4.791E-11 3.615E-10 2.204E-9 7 68
47 GO:0045980 negative regulation of nucleotide metabolic process 2.562E-12 5.790E-11 4.369E-10 2.721E-9 7 70
48 GO:0051937 catecholamine transport 2.840E-12 6.284E-11 4.742E-10 3.016E-9 7 71
49 GO:0042417 dopamine metabolic process 5.268E-12 1.142E-10 8.615E-10 5.594E-9 6 37
50 GO:0043271 negative regulation of ion transport 7.359E-12 1.563E-10 1.179E-9 7.815E-9 8 145
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 24 input genes in category / 99 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043197 dendritic spine 1.141E-13 6.371E-12 3.298E-11 1.130E-11 9 151
2 GO:0044309 neuron spine 1.287E-13 6.371E-12 3.298E-11 1.274E-11 9 153
3 GO:0098794 postsynapse 2.079E-12 6.860E-11 3.552E-10 2.058E-10 11 449
4 GO:0072357 PTW/PP1 phosphatase complex 6.118E-8 1.487E-6 7.700E-6 6.057E-6 3 7
5 GO:0033267 axon part 7.511E-8 1.487E-6 7.700E-6 7.436E-6 7 309
6 GO:0008287 protein serine/threonine phosphatase complex 4.282E-7 6.056E-6 3.135E-5 4.239E-5 4 50
7 GO:1903293 phosphatase complex 4.282E-7 6.056E-6 3.135E-5 4.239E-5 4 50
8 GO:0000164 protein phosphatase type 1 complex 4.975E-7 6.156E-6 3.187E-5 4.925E-5 3 13
9 GO:0043679 axon terminus 3.065E-6 3.184E-5 1.649E-4 3.035E-4 5 186
10 GO:0098793 presynapse 3.217E-6 3.184E-5 1.649E-4 3.184E-4 6 341
11 GO:0044306 neuron projection terminus 4.266E-6 3.839E-5 1.988E-4 4.223E-4 5 199
12 GO:0042587 glycogen granule 4.235E-5 3.494E-4 1.809E-3 4.192E-3 2 8
13 GO:0043198 dendritic shaft 5.726E-5 4.360E-4 2.257E-3 5.668E-3 3 60
14 GO:0035097 histone methyltransferase complex 1.030E-4 7.280E-4 3.769E-3 1.019E-2 3 73
15 GO:0042734 presynaptic membrane 1.161E-4 7.661E-4 3.966E-3 1.149E-2 3 76
16 GO:0060170 ciliary membrane 1.676E-4 1.037E-3 5.369E-3 1.659E-2 3 86
17 GO:0005791 rough endoplasmic reticulum 2.046E-4 1.125E-3 5.827E-3 2.026E-2 3 92
18 GO:0034708 methyltransferase complex 2.046E-4 1.125E-3 5.827E-3 2.026E-2 3 92
19 GO:0000784 nuclear chromosome, telomeric region 6.038E-4 3.146E-3 1.629E-2
5.978E-2
 3 133
20 GO:0031253 cell projection membrane 7.291E-4 3.444E-3 1.783E-2
7.218E-2
 4 332
21 GO:0043204 perikaryon 7.305E-4 3.444E-3 1.783E-2
7.232E-2
 3 142
22 GO:0048786 presynaptic active zone 9.850E-4 4.433E-3 2.295E-2
9.752E-2
 2 37
23 GO:0000781 chromosome, telomeric region 1.070E-3 4.605E-3 2.384E-2
1.059E-1
 3 162
24 GO:0097060 synaptic membrane 6.004E-3 2.364E-2
1.224E-1
5.944E-1
 3 298
25 GO:0044326 dendritic spine neck 6.280E-3 2.364E-2
1.224E-1
6.218E-1
 1 5
26 GO:0048787 presynaptic active zone membrane 6.280E-3 2.364E-2
1.224E-1
6.218E-1
 1 5
27 GO:0005901 caveola 6.446E-3 2.364E-2
1.224E-1
6.382E-1
 2 96
28 GO:0044853 plasma membrane raft 7.665E-3 2.710E-2
1.403E-1
7.589E-1
 2 105
29 GO:0043195 terminal bouton 8.680E-3 2.938E-2
1.521E-1
8.593E-1
 2 112
30 GO:0098687 chromosomal region 8.904E-3 2.938E-2
1.521E-1
8.815E-1
 3 344
31 GO:0044441 ciliary part 9.553E-3 3.051E-2
1.579E-1
9.457E-1
 3 353
32 GO:0043203 axon hillock 1.003E-2 3.103E-2
1.607E-1
9.930E-1
 1 8
33 GO:0044327 dendritic spine head 1.128E-2 3.383E-2
1.752E-1
1.000E0
 1 9
34 GO:0070852 cell body fiber 1.501E-2 4.370E-2
2.263E-1
1.000E0
 1 12
35 GO:0097449 astrocyte projection 1.625E-2 4.489E-2
2.324E-1
1.000E0
 1 13
36 GO:0008021 synaptic vesicle 1.632E-2 4.489E-2
2.324E-1
1.000E0
 2 156
Show 31 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 136 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 21 input genes in category / 695 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0009745 abnormal behavioral response to xenobiotic 7.674E-14 5.333E-11 3.798E-10 5.333E-11 12 304
2 MP:0002065 abnormal fear/anxiety-related behavior 6.555E-11 2.278E-8 1.622E-7 4.556E-8 11 402
3 MP:0001362 abnormal anxiety-related response 1.364E-8 2.698E-6 1.922E-5 9.483E-6 9 360
4 MP:0009747 impaired behavioral response to xenobiotic 1.553E-8 2.698E-6 1.922E-5 1.079E-5 6 88
5 MP:0009748 abnormal behavioral response to addictive substance 4.515E-8 5.264E-6 3.749E-5 3.138E-5 6 105
6 MP:0009750 impaired behavioral response to addictive substance 4.545E-8 5.264E-6 3.749E-5 3.159E-5 5 51
7 MP:0002906 increased susceptibility to pharmacologically induced seizures 5.971E-8 5.780E-6 4.116E-5 4.150E-5 6 110
8 MP:0012349 increased susceptibility to induction of seizure by inducing agent 6.653E-8 5.780E-6 4.116E-5 4.624E-5 6 112
9 MP:0020157 abnormal behavioral response to alcohol 8.930E-8 6.896E-6 4.911E-5 6.206E-5 4 22
10 MP:0002062 abnormal associative learning 1.066E-7 7.409E-6 5.277E-5 7.409E-5 8 319
11 MP:0000950 abnormal seizure response to pharmacological agent 2.313E-7 1.461E-5 1.041E-4 1.607E-4 6 138
12 MP:0009746 enhanced behavioral response to xenobiotic 4.205E-7 2.436E-5 1.735E-4 2.923E-4 5 79
13 MP:0003107 abnormal response to novelty 6.610E-7 3.534E-5 2.517E-4 4.594E-4 7 271
14 MP:0008911 induced hyperactivity 1.090E-6 5.409E-5 3.852E-4 7.573E-4 4 40
15 MP:0001906 increased dopamine level 1.206E-6 5.587E-5 3.979E-4 8.380E-4 4 41
16 MP:0001905 abnormal dopamine level 1.661E-6 7.216E-5 5.139E-4 1.155E-3 5 104
17 MP:0009357 abnormal seizure response to inducing agent 1.771E-6 7.239E-5 5.155E-4 1.231E-3 6 195
18 MP:0002803 abnormal operant conditioning behavior 2.580E-6 9.436E-5 6.720E-4 1.793E-3 3 14
19 MP:0008802 abnormal intestinal smooth muscle morphology 2.580E-6 9.436E-5 6.720E-4 1.793E-3 3 14
20 MP:0009749 enhanced behavioral response to addictive substance 2.937E-6 1.020E-4 7.268E-4 2.041E-3 4 51
21 MP:0009751 enhanced behavioral response to alcohol 3.958E-6 1.310E-4 9.329E-4 2.751E-3 3 16
22 MP:0002064 seizures 7.494E-6 2.367E-4 1.686E-3 5.208E-3 7 390
23 MP:0011479 abnormal catecholamine level 1.219E-5 3.683E-4 2.623E-3 8.470E-3 5 156
24 MP:0009765 abnormal xenobiotic induced morbidity/mortality 1.902E-5 5.509E-4 3.923E-3 1.322E-2 5 171
25 MP:0009712 impaired conditioned place preference behavior 2.280E-5 6.267E-4 4.464E-3 1.584E-2 3 28
26 MP:0006003 abnormal large intestinal transit time 2.345E-5 6.267E-4 4.464E-3 1.630E-2 2 4
27 MP:0002629 hyperactivity elicited by ethanol administration 3.903E-5 9.562E-4 6.810E-3 2.713E-2 2 5
28 MP:0010167 decreased response to stress-induced hyperthermia 3.903E-5 9.562E-4 6.810E-3 2.713E-2 2 5
29 MP:0002574 increased vertical activity 3.990E-5 9.562E-4 6.810E-3 2.773E-2 4 98
30 MP:0001413 abnormal response to new environment 4.142E-5 9.596E-4 6.834E-3 2.879E-2 5 201
31 MP:0009711 abnormal conditioned place preference behavior 4.917E-5 1.102E-3 7.850E-3 3.417E-2 3 36
32 MP:0020158 abnormal behavioral response to cocaine 5.344E-5 1.161E-3 8.265E-3 3.714E-2 3 37
33 MP:0002204 abnormal neurotransmitter level 7.094E-5 1.491E-3 1.062E-2 4.931E-2 5 225
34 MP:0002573 behavioral despair 7.293E-5 1.491E-3 1.062E-2
5.069E-2
 3 41
35 MP:0003463 abnormal single cell response 7.844E-5 1.542E-3 1.098E-2
5.451E-2
 3 42
36 MP:0001505 hunched posture 7.986E-5 1.542E-3 1.098E-2
5.551E-2
 4 117
37 MP:0006143 increased systemic arterial diastolic blood pressure 8.421E-5 1.582E-3 1.127E-2
5.853E-2
 3 43
38 MP:0001463 abnormal spatial learning 1.146E-4 2.097E-3 1.493E-2
7.967E-2
 5 249
39 MP:0003360 abnormal depression-related behavior 1.239E-4 2.208E-3 1.573E-2
8.612E-2
 4 131
40 MP:0012317 impaired conditioning behavior 1.276E-4 2.217E-3 1.579E-2
8.869E-2
 4 132
41 MP:0003460 decreased fear-related response 1.325E-4 2.246E-3 1.600E-2
9.211E-2
 3 50
42 MP:0009755 impaired behavioral response to alcohol 1.398E-4 2.273E-3 1.619E-2
9.718E-2
 2 9
43 MP:0005156 bradykinesia 1.406E-4 2.273E-3 1.619E-2
9.774E-2
 3 51
44 MP:0010165 abnormal response to stress-induced hyperthermia 2.131E-4 3.360E-3 2.393E-2
1.481E-1
 2 11
45 MP:0020167 abnormal vertical activity 2.176E-4 3.360E-3 2.393E-2
1.512E-1
 6 456
46 MP:0008874 decreased physiological sensitivity to xenobiotic 2.231E-4 3.371E-3 2.401E-2
1.551E-1
 5 287
47 MP:0013189 abnormal exploration in a new environment 2.551E-4 3.772E-3 2.686E-2
1.773E-1
 4 158
48 MP:0001364 decreased anxiety-related response 2.741E-4 3.969E-3 2.826E-2
1.905E-1
 4 161
49 MP:0001405 impaired coordination 2.941E-4 4.171E-3 2.970E-2
2.044E-1
 6 482
50 MP:0001469 abnormal contextual conditioning behavior 3.081E-4 4.282E-3 3.050E-2
2.141E-1
 4 166
Show 45 more annotations

6: Domain [Display Chart] 24 input genes in category / 76 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM01381 7TM GPCR Srsx SMART 1.434E-23 1.090E-21 5.356E-21 1.090E-21 13 112
2 IPR002231 5HT rcpt InterPro 7.747E-20 2.944E-18 1.447E-17 5.888E-18 7 9
3 IPR000929 Dopamine rcpt InterPro 2.211E-15 5.601E-14 2.753E-13 1.680E-13 5 5
4 PF16891 STPPase N Pfam 1.847E-9 2.807E-8 1.380E-7 1.404E-7 3 3
5 IPR031675 STPPase N InterPro 1.847E-9 2.807E-8 1.380E-7 1.404E-7 3 3
6 IPR000162 GPCR 3 mtglu rcpt InterPro 1.030E-7 1.305E-6 6.412E-6 7.828E-6 3 8
7 SM00156 PP2Ac SMART 5.238E-7 3.619E-6 1.779E-5 3.981E-5 3 13
8 IPR006186 Ser/Thr-sp prot-phosphatase InterPro 5.238E-7 3.619E-6 1.779E-5 3.981E-5 3 13
9 IPR011500 GPCR 3 9-Cys dom InterPro 5.238E-7 3.619E-6 1.779E-5 3.981E-5 3 13
10 PS00125 SER THR PHOSPHATASE PROSITE 5.238E-7 3.619E-6 1.779E-5 3.981E-5 3 13
11 PF07562 NCD3G Pfam 5.238E-7 3.619E-6 1.779E-5 3.981E-5 3 13
12 IPR017979 GPCR 3 CS InterPro 6.661E-7 4.219E-6 2.073E-5 5.063E-5 3 14
13 IPR000337 GPCR 3 InterPro 2.420E-6 1.120E-5 5.503E-5 1.839E-4 3 21
14 PF00003 7tm 3 Pfam 2.799E-6 1.120E-5 5.503E-5 2.127E-4 3 22
15 PS00979 G PROTEIN RECEP F3 1 PROSITE 2.799E-6 1.120E-5 5.503E-5 2.127E-4 3 22
16 PS00980 G PROTEIN RECEP F3 2 PROSITE 2.799E-6 1.120E-5 5.503E-5 2.127E-4 3 22
17 IPR017978 GPCR 3 C InterPro 2.799E-6 1.120E-5 5.503E-5 2.127E-4 3 22
18 PS00981 G PROTEIN RECEP F3 3 PROSITE 2.799E-6 1.120E-5 5.503E-5 2.127E-4 3 22
19 PS50259 G PROTEIN RECEP F3 4 PROSITE 2.799E-6 1.120E-5 5.503E-5 2.127E-4 3 22
20 PF00149 Metallophos Pfam 5.925E-6 2.144E-5 1.054E-4 4.503E-4 3 28
21 IPR004843 Calcineurin-like PHP ApaH InterPro 5.925E-6 2.144E-5 1.054E-4 4.503E-4 3 28
22 3.60.21.10 - Gene3D 7.331E-6 2.422E-5 1.190E-4 5.571E-4 3 30
23 IPR029052 Metallo-depent PP-like InterPro 7.331E-6 2.422E-5 1.190E-4 5.571E-4 3 30
24 PF01094 ANF receptor Pfam 1.395E-5 4.240E-5 2.084E-4 1.060E-3 3 37
25 IPR001828 ANF lig-bd rcpt InterPro 1.395E-5 4.240E-5 2.084E-4 1.060E-3 3 37
26 IPR028082 Peripla BP I InterPro 1.638E-5 4.787E-5 2.353E-4 1.245E-3 3 39
27 IPR001413 Dopamine D1 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
28 IPR000497 Dopamine D5 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
29 IPR001520 5HT4 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
30 IPR001234 GPCR 3 mtglu rcpt 3 InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
31 IPR000482 5HT2B rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
32 IPR000455 5HT2A rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
33 IPR001922 Dopamine D2 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
34 IPR001883 GPCR 3 mtglu rcpt 7 InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
35 IPR001069 5HT 7 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
36 IPR001397 5HT5A rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
37 IPR002185 Dopamine D4 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
38 IPR000610 5HT1A rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
39 IPR000377 5HT2C rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
40 IPR001458 GPCR 3 mtglu rcpt 2 InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
41 IPR033360 TIAM1 InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
42 IPR000505 5HT1D rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
43 IPR002147 5HT1B rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
44 IPR001620 Dopamine D3 rcpt InterPro 1.281E-3 2.213E-3 1.087E-2
9.736E-2
 1 1
45 IPR007062 PPI-2 InterPro 2.560E-3 4.230E-3 2.079E-2
1.946E-1
 1 2
46 PF04979 IPP-2 Pfam 2.560E-3 4.230E-3 2.079E-2
1.946E-1
 1 2
47 PF02196 RBD Pfam 7.663E-3 1.213E-2
5.963E-2
5.824E-1
 1 6
48 IPR001671 Melcrt ACTH rcpt InterPro 7.663E-3 1.213E-2
5.963E-2
5.824E-1
 1 6
49 SM00455 RBD SMART 8.934E-3 1.331E-2
6.543E-2
6.790E-1
 1 7
50 PS50898 RBD PROSITE 8.934E-3 1.331E-2
6.543E-2
6.790E-1
 1 7
Show 45 more annotations

7: Pathway [Display Chart] 23 input genes in category / 129 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269553 Amine ligand-binding receptors BioSystems: REACTOME 3.600E-33 4.644E-31 2.527E-30 4.644E-31 15 43
2 P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PantherDB 3.204E-31 2.066E-29 1.124E-28 4.133E-29 18 150
3 1269558 Serotonin receptors BioSystems: REACTOME 3.068E-27 1.319E-25 7.177E-25 3.957E-25 10 12
4 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 3.345E-26 1.079E-24 5.870E-24 4.315E-24 18 278
5 1269544 GPCR ligand binding BioSystems: REACTOME 2.767E-22 7.138E-21 3.884E-20 3.569E-20 18 455
6 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 4.563E-19 9.811E-18 5.338E-17 5.887E-17 15 322
7 1017634 cAMP signaling pathway BioSystems: KEGG 2.174E-16 4.006E-15 2.180E-14 2.804E-14 12 198
8 525336 Serotonergic synapse BioSystems: KEGG 2.621E-15 4.226E-14 2.299E-13 3.381E-13 10 113
9 PW:0000394 dopamine signaling Pathway Ontology 1.351E-14 1.743E-13 9.482E-13 1.743E-12 5 5
10 1269556 Dopamine receptors BioSystems: REACTOME 1.351E-14 1.743E-13 9.482E-13 1.743E-12 5 5
11 P05912 Dopamine receptor mediated signaling pathway PantherDB 3.395E-12 3.981E-11 2.166E-10 4.379E-10 7 52
12 1269576 G alpha (i) signalling events BioSystems: REACTOME 6.109E-12 6.567E-11 3.573E-10 7.881E-10 10 243
13 P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PantherDB 1.357E-11 1.346E-10 7.325E-10 1.750E-9 8 111
14 83050 Calcium signaling pathway BioSystems: KEGG 1.713E-11 1.579E-10 8.590E-10 2.210E-9 9 182
15 469199 Dopaminergic synapse BioSystems: KEGG 4.889E-11 4.205E-10 2.288E-9 6.307E-9 8 130
16 948277 Inflammatory mediator regulation of TRP channels BioSystems: KEGG 1.735E-8 1.399E-7 7.612E-7 2.238E-6 6 97
17 P06587 Nicotine pharmacodynamics pathway PantherDB 2.039E-7 1.547E-6 8.417E-6 2.630E-5 4 29
18 83072 Gap junction BioSystems: KEGG 4.788E-7 3.431E-6 1.867E-5 6.176E-5 5 88
19 546258 Cocaine addiction BioSystems: KEGG 1.775E-6 1.205E-5 6.556E-5 2.289E-4 4 49
20 M16626 Regulation of ck1/cdk5 by type 1 glutamate receptors MSigDB C2 BIOCARTA (v6.0) 3.683E-6 2.375E-5 1.292E-4 4.750E-4 3 17
21 PW:0000532 glycogen biosynthetic Pathway Ontology 4.414E-6 2.711E-5 1.475E-4 5.694E-4 3 18
22 1269575 G alpha (s) signalling events BioSystems: REACTOME 5.877E-6 3.446E-5 1.875E-4 7.581E-4 5 146
23 1270009 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis BioSystems: REACTOME 6.151E-6 3.450E-5 1.877E-4 7.935E-4 3 20
24 547607 Amphetamine addiction BioSystems: KEGG 6.665E-6 3.582E-5 1.949E-4 8.597E-4 4 68
25 PW:0000534 glycogen degradation Pathway Ontology 1.087E-5 5.608E-5 3.051E-4 1.402E-3 3 24
26 1269525 Downregulation of TGF-beta receptor signaling BioSystems: REACTOME 1.565E-5 7.765E-5 4.225E-4 2.019E-3 3 27
27 585563 Alcoholism BioSystems: KEGG 1.628E-5 7.777E-5 4.231E-4 2.100E-3 5 180
28 PW:0000061 long term depression Pathway Ontology 1.954E-5 9.004E-5 4.899E-4 2.521E-3 2 4
29 1269524 TGF-beta receptor signaling activates SMADs BioSystems: REACTOME 3.175E-5 1.412E-4 7.684E-4 4.096E-3 3 34
30 SMP00311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin SMPDB 4.875E-5 2.029E-4 1.104E-3 6.289E-3 2 6
31 SMP00312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin SMPDB 4.875E-5 2.029E-4 1.104E-3 6.289E-3 2 6
32 1269573 Class C/3 (Metabotropic glutamate/pheromone receptors) BioSystems: REACTOME 5.204E-5 2.098E-4 1.141E-3 6.713E-3 3 40
33 P04373 5HT1 type receptor mediated signaling pathway PantherDB 6.477E-5 2.532E-4 1.378E-3 8.355E-3 3 43
34 PW:0000060 long term potentiation Pathway Ontology 1.166E-4 4.424E-4 2.407E-3 1.504E-2 2 9
35 PW:0000455 Excitatory synaptic transmission Pathway Ontology 1.456E-4 5.366E-4 2.920E-3 1.878E-2 2 10
36 P04374 5HT2 type receptor mediated signaling pathway PantherDB 2.035E-4 7.291E-4 3.967E-3 2.625E-2 3 63
37 83085 Long-term potentiation BioSystems: KEGG 2.443E-4 8.516E-4 4.633E-3 3.151E-2 3 67
38 1269871 Circadian Clock BioSystems: REACTOME 2.900E-4 9.845E-4 5.357E-3 3.741E-2 3 71
39 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 3.685E-4 1.219E-3 6.632E-3 4.754E-2 3 77
40 83088 Taste transduction BioSystems: KEGG 4.595E-4 1.482E-3 8.064E-3
5.928E-2
 3 83
41 782000 Proteoglycans in cancer BioSystems: KEGG 4.765E-4 1.499E-3 8.157E-3
6.146E-2
 4 203
42 83089 Regulation of actin cytoskeleton BioSystems: KEGG 5.612E-4 1.724E-3 9.379E-3
7.240E-2
 4 212
43 193328 mRNA surveillance pathway BioSystems: KEGG 6.018E-4 1.805E-3 9.823E-3
7.763E-2
 3 91
44 1272486 Insulin resistance BioSystems: KEGG 9.645E-4 2.828E-3 1.538E-2
1.244E-1
 3 107
45 213818 Glutamatergic synapse BioSystems: KEGG 1.159E-3 3.321E-3 1.807E-2
1.495E-1
 3 114
46 1270002 Lipid digestion, mobilization, and transport BioSystems: REACTOME 1.188E-3 3.332E-3 1.813E-2
1.533E-1
 3 115
47 96530 Vascular smooth muscle contraction BioSystems: KEGG 1.376E-3 3.776E-3 2.055E-2
1.775E-1
 3 121
48 952858 Platelet activation BioSystems: KEGG 1.442E-3 3.876E-3 2.109E-2
1.861E-1
 3 123
49 126909 Oocyte meiosis BioSystems: KEGG 1.476E-3 3.887E-3 2.115E-2
1.905E-1
 3 124
50 83090 Insulin signaling pathway BioSystems: KEGG 2.006E-3 5.176E-3 2.816E-2
2.588E-1
 3 138
Show 45 more annotations

8: Pubmed [Display Chart] 24 input genes in category / 5840 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19156168 Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Pubmed 2.235E-41 1.305E-37 1.207E-36 1.305E-37 18 118
2 19086053 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Pubmed 3.642E-31 1.063E-27 9.836E-27 2.127E-27 17 301
3 18240029 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Pubmed 4.485E-29 6.874E-26 6.359E-25 2.620E-25 15 200
4 19455600 Association study of the serotoninergic system in migraine in the Spanish population. Pubmed 4.708E-29 6.874E-26 6.359E-25 2.750E-25 10 18
5 18855532 Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pubmed 1.509E-28 1.763E-25 1.631E-24 8.815E-25 9 11
6 18270970 Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies. Pubmed 3.791E-28 3.690E-25 3.413E-24 2.214E-24 10 21
7 19737523 A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Pubmed 3.509E-27 2.928E-24 2.708E-23 2.049E-23 10 25
8 11140838 A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Pubmed 8.876E-26 6.479E-23 5.993E-22 5.183E-22 11 58
9 28031476 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. Pubmed 1.964E-25 1.275E-22 1.179E-21 1.147E-21 10 35
10 20468064 Association study of 182 candidate genes in anorexia nervosa. Pubmed 1.007E-24 5.882E-22 5.440E-21 5.882E-21 13 182
11 18079067 Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Pubmed 1.964E-23 1.043E-20 9.644E-20 1.147E-19 8 14
12 18577758 Dissociation of heterotrimeric g proteins in cells. Pubmed 4.154E-20 2.022E-17 1.870E-16 2.426E-16 11 179
13 19874574 Genetical genomic determinants of alcohol consumption in rats and humans. Pubmed 2.761E-19 1.240E-16 1.147E-15 1.613E-15 10 130
14 20071033 Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. Pubmed 8.739E-19 3.402E-16 3.147E-15 5.103E-15 6 8
15 19636338 Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome. Pubmed 8.739E-19 3.402E-16 3.147E-15 5.103E-15 6 8
16 18583979 Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Pubmed 4.852E-18 1.771E-15 1.638E-14 2.834E-14 8 52
17 19352218 Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. Pubmed 1.729E-17 5.940E-15 5.494E-14 1.010E-13 7 28
18 11916537 Multiplicity of mechanisms of serotonin receptor signal transduction. Pubmed 2.879E-17 8.849E-15 8.185E-14 1.681E-13 6 12
19 15717291 Support for association between ADHD and two candidate genes: NET1 and DRD1. Pubmed 2.879E-17 8.849E-15 8.185E-14 1.681E-13 6 12
20 19105202 Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
21 26597879 The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
22 23445730 [Dopamine receptor signaling regulates human osteoclastogenesis]. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
23 8833759 An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
24 17509542 Dopamine receptor mRNA and protein expression in the mouse corpus striatum and cerebral cortex during pre- and postnatal development. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
25 9457173 Dopamine receptors: from structure to function. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
26 18083900 Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
27 12509874 Neuron-specific age-related decreases in dopamine receptor subtype mRNAs. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
28 20714340 Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
29 22219295 Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes. Pubmed 6.278E-17 1.264E-14 1.169E-13 3.666E-13 5 5
30 21982372 Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA. Pubmed 3.765E-16 7.093E-14 6.561E-13 2.199E-12 5 6
31 20531939 DISC1 regulates primary cilia that display specific dopamine receptors. Pubmed 3.765E-16 7.093E-14 6.561E-13 2.199E-12 5 6
32 19506906 Candidate gene studies of ADHD: a meta-analytic review. Pubmed 5.770E-16 1.053E-13 9.741E-13 3.370E-12 6 18
33 19000940 Correlates of response to Olanzapine in a North Indian Schizophrenia sample. Pubmed 1.317E-15 2.198E-13 2.033E-12 7.693E-12 5 7
34 12627464 Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Pubmed 1.317E-15 2.198E-13 2.033E-12 7.693E-12 5 7
35 16770336 Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. Pubmed 1.317E-15 2.198E-13 2.033E-12 7.693E-12 5 7
36 20351714 Poor replication of candidate genes for major depressive disorder using genome-wide association data. Pubmed 1.676E-15 2.718E-13 2.514E-12 9.785E-12 7 51
37 19997080 Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions. Pubmed 3.511E-15 5.542E-13 5.126E-12 2.051E-11 5 8
38 19772578 Two-stage case-control association study of dopamine-related genes and migraine. Pubmed 7.897E-15 1.125E-12 1.040E-11 4.612E-11 5 9
39 18821566 SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. Pubmed 7.897E-15 1.125E-12 1.040E-11 4.612E-11 5 9
40 16525059 Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. Pubmed 7.897E-15 1.125E-12 1.040E-11 4.612E-11 5 9
41 26053401 Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved. Pubmed 7.897E-15 1.125E-12 1.040E-11 4.612E-11 5 9
42 19058789 A common variant in DRD3 receptor is associated with autism spectrum disorder. Pubmed 9.550E-15 1.328E-12 1.228E-11 5.577E-11 8 129
43 19032968 Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. Pubmed 1.579E-14 2.095E-12 1.938E-11 9.220E-11 5 10
44 21083670 Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Pubmed 1.579E-14 2.095E-12 1.938E-11 9.220E-11 5 10
45 22640814 Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning. Pubmed 8.053E-14 1.022E-11 9.456E-11 4.703E-10 5 13
46 22569571 Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Pubmed 8.053E-14 1.022E-11 9.456E-11 4.703E-10 5 13
47 19235789 Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease. Pubmed 1.199E-13 1.094E-11 1.012E-10 7.000E-10 4 4
48 7656980 Expression of serotonin receptor mRNAs in blood vessels. Pubmed 1.199E-13 1.094E-11 1.012E-10 7.000E-10 4 4
49 18197272 Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults. Pubmed 1.199E-13 1.094E-11 1.012E-10 7.000E-10 4 4
50 17102980 Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients. Pubmed 1.199E-13 1.094E-11 1.012E-10 7.000E-10 4 4
Show 45 more annotations

9: Interaction [Display Chart] 23 input genes in category / 950 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PPP1R9B PPP1R9B interactions 4.101E-11 3.896E-8 2.896E-7 3.896E-8 6 51
2 int:PPP1R11 PPP1R11 interactions 1.536E-9 7.295E-7 5.423E-6 1.459E-6 4 13
3 int:GNAQ GNAQ interactions 2.607E-9 8.255E-7 6.137E-6 2.477E-6 6 100
4 int:CSRNP2 CSRNP2 interactions 7.656E-9 1.212E-6 9.012E-6 7.273E-6 3 4
5 int:PPP1R2B PPP1R2B interactions 7.656E-9 1.212E-6 9.012E-6 7.273E-6 3 4
6 int:HTR1D HTR1D interactions 7.656E-9 1.212E-6 9.012E-6 7.273E-6 3 4
7 int:CLIC6 CLIC6 interactions 1.912E-8 2.595E-6 1.929E-5 1.817E-5 3 5
8 int:SFRP5 SFRP5 interactions 3.821E-8 4.538E-6 3.374E-5 3.630E-5 3 6
9 int:HTR1B HTR1B interactions 6.682E-8 7.053E-6 5.243E-5 6.348E-5 3 7
10 int:LMTK2 LMTK2 interactions 8.639E-8 8.207E-6 6.101E-5 8.207E-5 4 33
11 int:FLNA FLNA interactions 1.336E-7 1.154E-5 8.577E-5 1.269E-4 7 328
12 int:HTR1A HTR1A interactions 2.285E-7 1.670E-5 1.241E-4 2.171E-4 3 10
13 int:C20orf27 C20orf27 interactions 2.285E-7 1.670E-5 1.241E-4 2.171E-4 3 10
14 int:PLCL2 PLCL2 interactions 3.139E-7 2.130E-5 1.584E-4 2.982E-4 3 11
15 int:PPP1R2 PPP1R2 interactions 4.792E-7 3.035E-5 2.256E-4 4.552E-4 4 50
16 int:PPP1R7 PPP1R7 interactions 9.396E-7 5.579E-5 4.148E-4 8.927E-4 4 59
17 int:DLG4 DLG4 interactions 1.053E-6 5.600E-5 4.163E-4 1.000E-3 6 274
18 int:SFRP1 SFRP1 interactions 1.061E-6 5.600E-5 4.163E-4 1.008E-3 3 16
19 int:PPP1R15B PPP1R15B interactions 2.153E-6 1.076E-4 8.001E-4 2.045E-3 3 20
20 int:SFRP2 SFRP2 interactions 2.509E-6 1.192E-4 8.860E-4 2.384E-3 3 21
21 int:CDCA2 CDCA2 interactions 2.903E-6 1.254E-4 9.319E-4 2.758E-3 3 22
22 int:SHOC2 SHOC2 interactions 2.903E-6 1.254E-4 9.319E-4 2.758E-3 3 22
23 int:PPP1R16A PPP1R16A interactions 3.809E-6 1.573E-4 1.170E-3 3.618E-3 3 24
24 int:TPRN TPRN interactions 4.324E-6 1.712E-4 1.273E-3 4.108E-3 3 25
25 int:LRRC1 LRRC1 interactions 6.144E-6 2.162E-4 1.607E-3 5.837E-3 3 28
26 int:PPP1R3C PPP1R3C interactions 6.144E-6 2.162E-4 1.607E-3 5.837E-3 3 28
27 int:KIF18A KIF18A interactions 6.144E-6 2.162E-4 1.607E-3 5.837E-3 3 28
28 int:PPP1R13L PPP1R13L interactions 6.847E-6 2.243E-4 1.667E-3 6.505E-3 3 29
29 int:RYR2 RYR2 interactions 6.847E-6 2.243E-4 1.667E-3 6.505E-3 3 29
30 int:UBXN2B UBXN2B interactions 7.601E-6 2.407E-4 1.789E-3 7.221E-3 3 30
31 int:DEC1 DEC1 interactions 9.271E-6 2.841E-4 2.112E-3 8.807E-3 3 32
32 int:NCS1 NCS1 interactions 1.019E-5 2.933E-4 2.181E-3 9.680E-3 3 33
33 int:PPP1R15A PPP1R15A interactions 1.019E-5 2.933E-4 2.181E-3 9.680E-3 3 33
34 int:RASSF7 RASSF7 interactions 1.117E-5 3.120E-4 2.319E-3 1.061E-2 3 34
35 int:GYS1 GYS1 interactions 1.569E-5 4.140E-4 3.078E-3 1.490E-2 3 38
36 int:RASSF9 RASSF9 interactions 1.569E-5 4.140E-4 3.078E-3 1.490E-2 3 38
37 int:PPP1R16B PPP1R16B interactions 1.698E-5 4.184E-4 3.111E-3 1.613E-2 3 39
38 int:RORC RORC interactions 1.698E-5 4.184E-4 3.111E-3 1.613E-2 3 39
39 int:PRKCB PRKCB interactions 1.718E-5 4.184E-4 3.111E-3 1.632E-2 4 122
40 int:AKAP11 AKAP11 interactions 1.977E-5 4.696E-4 3.491E-3 1.878E-2 3 41
41 int:PPP1R9A PPP1R9A interactions 2.128E-5 4.812E-4 3.578E-3 2.021E-2 3 42
42 int:PPP1R10 PPP1R10 interactions 2.128E-5 4.812E-4 3.578E-3 2.021E-2 3 42
43 int:TP53BP2 TP53BP2 interactions 2.274E-5 4.934E-4 3.668E-3 2.160E-2 4 131
44 int:PDRG1 PDRG1 interactions 2.285E-5 4.934E-4 3.668E-3 2.171E-2 3 43
45 int:PPP1R32 PPP1R32 interactions 2.414E-5 4.986E-4 3.707E-3 2.294E-2 2 6
46 int:KCNJ9 KCNJ9 interactions 2.414E-5 4.986E-4 3.707E-3 2.294E-2 2 6
47 int:PPP1R3A PPP1R3A interactions 2.992E-5 5.686E-4 4.227E-3 2.843E-2 3 47
48 int:NEK2 NEK2 interactions 2.992E-5 5.686E-4 4.227E-3 2.843E-2 3 47
49 int:ZFYVE9 ZFYVE9 interactions 2.992E-5 5.686E-4 4.227E-3 2.843E-2 3 47
50 int:PPP2R5C PPP2R5C interactions 2.992E-5 5.686E-4 4.227E-3 2.843E-2 3 47
Show 45 more annotations

10: Cytoband [Display Chart] 24 input genes in category / 24 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q21.1-q21.2 7q21.1-q21.2 6.924E-4 3.324E-3 1.255E-2 1.662E-2 1 1
2 5q11.2-q13 5q11.2-q13 6.924E-4 3.324E-3 1.255E-2 1.662E-2 1 1
3 10q21-q24 10q21-q24 6.924E-4 3.324E-3 1.255E-2 1.662E-2 1 1
4 2q36.3-q37.1 2q36.3-q37.1 6.924E-4 3.324E-3 1.255E-2 1.662E-2 1 1
5 1p36.3-p34.3 1p36.3-p34.3 6.924E-4 3.324E-3 1.255E-2 1.662E-2 1 1
6 3p26.1-p25.1 3p26.1-p25.1 1.384E-3 5.536E-3 2.090E-2 3.323E-2 1 2
7 13q14-q21 13q14-q21 2.076E-3 5.536E-3 2.090E-2 4.982E-2 1 3
8 1p36-p35 1p36-p35 2.076E-3 5.536E-3 2.090E-2 4.982E-2 1 3
9 12q24.1-q24.2 12q24.1-q24.2 2.076E-3 5.536E-3 2.090E-2 4.982E-2 1 3
10 3q13.3 3q13.3 2.767E-3 6.641E-3 2.507E-2
6.641E-2
 1 4
11 5q31-q33 5q31-q33 7.591E-3 1.656E-2
6.254E-2
1.822E-1
 1 11
12 2p23 2p23 1.171E-2 2.342E-2
8.842E-2
2.810E-1
 1 17
13 3p21.2 3p21.2 1.376E-2 2.541E-2
9.593E-2
3.303E-1
 1 20
14 11q23 11q23 2.464E-2 4.202E-2
1.587E-1
5.914E-1
 1 36
15 6q13 6q13 2.667E-2 4.202E-2
1.587E-1
6.400E-1
 1 39
16 5q35.1 5q35.1 2.802E-2 4.202E-2
1.587E-1
6.724E-1
 1 41
17 19p13.1 19p13.1 3.272E-2 4.620E-2
1.744E-1
7.853E-1
 1 48
Show 12 more annotations

11: Transcription Factor Binding Site [Display Chart] 21 input genes in category / 182 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NRSF 01 V$NRSF 01 2.029E-5 3.694E-3 2.136E-2 3.694E-3 4 78
2 CAGNWMCNNNGAC UNKNOWN CAGNWMCNNNGAC UNKNOWN 4.453E-4 4.052E-2
2.344E-1
8.105E-2
 3 71

12: Gene Family [Display Chart] 24 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 170 5-hydroxytryptamine receptors, G protein-coupled genenames.org 5.123E-28 4.611E-27 1.304E-26 4.611E-27 10 13
2 181 Dopamine receptors genenames.org 2.560E-15 1.152E-14 3.259E-14 2.304E-14 5 5
3 281 Glutamate metabotropic receptors genenames.org 1.124E-7 3.373E-7 9.543E-7 1.012E-6 3 8
4 693 Protein phosphatase catalytic subunits genenames.org 5.718E-7 1.287E-6 3.640E-6 5.146E-6 3 13
5 694 Protein phosphatase 1 regulatory subunits genenames.org 2.353E-2 4.236E-2
1.198E-1
2.118E-1
 2 181

13: Coexpression [Display Chart] 24 input genes in category / 1394 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 3.533E-13 3.554E-10 2.779E-9 4.925E-10 11 462
2 20161705-Table2 Mouse EmbryonicStemCell Layden10 73genes GeneSigDB 5.099E-13 3.554E-10 2.779E-9 7.109E-10 7 69
3 M10376 Genes involved in glycogen metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.265E-9 2.447E-6 1.913E-5 7.340E-6 4 21
4 19074878-SuppTable1 Human Leukemia Hillion08 1176genes GeneSigDB 4.795E-6 1.671E-3 1.306E-2 6.684E-3 5 247
5 M1290 Genes involved in serotonin [PubChem=5202] function, orthologs computed from D. melanogaster genes using InsParanoid resource. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.543E-5 4.302E-3 3.363E-2 2.151E-2 2 6
6 M1954 Genes with high-CpG-density promoters (HCP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.185E-5 1.466E-2
1.146E-1
1.002E-1
 5 434
7 M1932 Genes with high-CpG-density promoters (HCP) bearing the H3K27 tri-methylation (H3K27me3) mark in neural precursor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.364E-5 1.466E-2
1.146E-1
1.026E-1
 3 79
8 M1562 Genes in cluster 2: moderately up-regulated in HFW cells (fibroblast) upon treatment with sodium arsenite [PubChem=26435] at all time points. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.562E-4 2.721E-2
2.128E-1
2.177E-1
 2 18
9 18812457-Table3 Mouse Viral Mercader08 29genes GeneSigDB 3.049E-4 4.722E-2
3.692E-1
4.250E-1
 2 25
10 M16297 Genes bearing the H3K27me3 mark in normal cells; their DNA is methylated in cancer cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.834E-4 4.742E-2
3.707E-1
5.345E-1
 2 28
11 M2009 Genes with high-CpG-density promoters (HCP) bearing histone H3 trimethylation mark at K27 (H3K27me3) in neural progenitor cells (NPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.902E-4 4.742E-2
3.707E-1
5.439E-1
 4 341
12 M2874 Genes down-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 4.082E-4 4.742E-2
3.707E-1
5.691E-1
 3 141
13 17287849-SuppTable1a Human Leukemia Pepper07 35genes GeneSigDB 4.708E-4 4.962E-2
3.879E-1
6.563E-1
 2 31
14 18223198-Table3 Human Brain Chen-Plotkin08 40genes FTLD-U GeneSigDB 5.339E-4 4.962E-2
3.879E-1
7.442E-1
 2 33
15 M3340 Genes up-regulated in CD38+ [GeneID=952] CLL (chronic lymphocytic leukemia) cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.339E-4 4.962E-2
3.879E-1
7.442E-1
 2 33
Show 10 more annotations

14: Coexpression Atlas [Display Chart] 24 input genes in category / 986 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Subtype Neuron.inhibitory.Gad1,Gad2.Drd1,Otof Striatum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Subtype Neuron.inhibitory.Gad1,Gad2.Drd1,Otof Striatum Top 200 Genes BrainMap 7.996E-6 3.942E-3 2.945E-2 7.884E-3 5 259
2 BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Top 200 BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Top 200 BrainMap 7.996E-6 3.942E-3 2.945E-2 7.884E-3 5 259
3 BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Striatum Striatum Overall Top 200 Genes BrainMap 3.043E-5 7.624E-3
5.696E-2
 3.001E-2 4 166
4 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6,Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6,Slc17a7 Top 200 Genes BrainMap 3.093E-5 7.624E-3
5.696E-2
 3.050E-2 5 343
5 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup8/Igfbp4 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup8/Igfbp4 BrainMap 7.191E-5 1.418E-2
1.060E-1
7.091E-2
 3 74
6 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 GlobusPallidus Top 200 Genes BrainMap 2.953E-4 4.433E-2
3.312E-1
2.911E-1
 4 299
7 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Gad1,Gad2 Top 200 Genes BrainMap 3.730E-4 4.433E-2
3.312E-1
3.678E-1
 4 318
8 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup9 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup9 Top 200 Genes BrainMap 4.193E-4 4.433E-2
3.312E-1
4.135E-1
 4 328
9 BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1 Striatum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1 Striatum Top 200 Genes BrainMap 4.340E-4 4.433E-2
3.312E-1
4.279E-1
 4 331
10 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/Striatum BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/Striatum BrainMap 4.834E-4 4.433E-2
3.312E-1
4.766E-1
 3 141
11 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/Striatum BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/Striatum BrainMap 4.946E-4 4.433E-2
3.312E-1
4.876E-1
 2 30
Show 6 more annotations

15: Computational [Display Chart] 19 input genes in category / 157 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10420 MODULE 274 Vesicular transport / synapse genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.836E-13 1.544E-10 8.705E-10 1.544E-10 8 82
2 M6672 MODULE 146 Genes in the cancer module 146. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.315E-8 1.817E-6 1.024E-5 3.635E-6 6 102
3 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.444E-5 1.802E-3 1.016E-2 5.407E-3 6 355
4 M3617 MORF LMO1 Neighborhood of LMO1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.066E-4 4.183E-3 2.358E-2 1.673E-2 3 50
5 M19754 MODULE 375 GPCR signaling pathways (immune and neuro). MSigDb: C4 - CM: Cancer Modules (v6.0) 6.089E-4 1.912E-2
1.078E-1
9.560E-2
 3 90
6 M12584 MODULE 289 Genes in the cancer module 289. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.543E-3 4.038E-2
2.276E-1
2.423E-1
 3 124
Show 1 more annotation

16: MicroRNA [Display Chart] 24 input genes in category / 641 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CCCAGAG,MIR-326:MSigDB CCCAGAG,MIR-326:MSigDB MSigDB 1.619E-5 6.794E-3 4.784E-2 1.038E-2 3 147
2 GTCTACC,MIR-379:MSigDB GTCTACC,MIR-379:MSigDB MSigDB 2.213E-5 6.794E-3 4.784E-2 1.418E-2 2 21
3 hsa-miR-154:PITA hsa-miR-154:PITA TOP PITA 3.817E-5 6.794E-3 4.784E-2 2.447E-2 3 196
4 hsa-miR-143:PITA hsa-miR-143:PITA TOP PITA 5.378E-5 6.794E-3 4.784E-2 3.448E-2 3 220
5 hsa-miR-1236:PITA hsa-miR-1236:PITA TOP PITA 6.960E-5 6.794E-3 4.784E-2 4.462E-2 3 240
6 hsa-miR-127-5p:PITA hsa-miR-127-5p:PITA TOP PITA 7.670E-5 6.794E-3 4.784E-2 4.916E-2 3 248
7 CACTGCC,MIR-34A:MSigDB CACTGCC,MIR-34A:MSigDB MSigDB 9.540E-5 6.794E-3 4.784E-2
6.115E-2
 3 267
8 CACTGCC,MIR-34C:MSigDB CACTGCC,MIR-34C:MSigDB MSigDB 9.540E-5 6.794E-3 4.784E-2
6.115E-2
 3 267
9 CACTGCC,MIR-449:MSigDB CACTGCC,MIR-449:MSigDB MSigDB 9.540E-5 6.794E-3 4.784E-2
6.115E-2
 3 267
10 hsa-miR-376c:PITA hsa-miR-376c:PITA TOP PITA 1.319E-4 8.231E-3
5.796E-2
8.454E-2
 3 298
11 TTTGTAG,MIR-520D:MSigDB TTTGTAG,MIR-520D:MSigDB MSigDB 1.481E-4 8.231E-3
5.796E-2
9.496E-2
 3 310
12 ATAACCT,MIR-154:MSigDB ATAACCT,MIR-154:MSigDB MSigDB 1.611E-4 8.231E-3
5.796E-2
1.033E-1
 2 56
13 hsa-miR-1280:mirSVR highEffct hsa-miR-1280:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.669E-4 8.231E-3
5.796E-2
1.070E-1
 2 57
14 hsa-miR-147b:mirSVR lowEffct hsa-miR-147b:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.877E-4 8.595E-3
6.051E-2
1.203E-1
 3 336
15 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 2.206E-4 9.067E-3
6.384E-2
1.414E-1
 3 355
16 hsa-miR-886-5p:mirSVR lowEffct hsa-miR-886-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.317E-4 9.067E-3
6.384E-2
1.485E-1
 3 361
17 AAGCACA,MIR-218:MSigDB AAGCACA,MIR-218:MSigDB MSigDB 2.490E-4 9.067E-3
6.384E-2
1.596E-1
 3 370
18 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 2.776E-4 9.067E-3
6.384E-2
1.779E-1
 3 384
19 hsa-miR-323a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.892E-4 9.067E-3
6.384E-2
1.854E-1
 2 75
20 hsa-miR-1225-5p:mirSVR highEffct hsa-miR-1225-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.927E-4 9.067E-3
6.384E-2
1.876E-1
 3 391
21 hsa-miR-711:mirSVR highEffct hsa-miR-711:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.970E-4 9.067E-3
6.384E-2
1.904E-1
 3 393
22 CAGGGTC,MIR-504:MSigDB CAGGGTC,MIR-504:MSigDB MSigDB 3.128E-4 9.113E-3
6.417E-2
2.005E-1
 2 78
23 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 3.941E-4 1.020E-2
7.183E-2
2.526E-1
 3 433
24 hsa-miR-6855-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.979E-4 1.020E-2
7.183E-2
2.551E-1
 2 88
25 hsa-miR-4513:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.979E-4 1.020E-2
7.183E-2
2.551E-1
 2 88
26 hsa-miR-379-5p:TargetScan hsa-miR-379-5p TargetScan 4.348E-4 1.072E-2
7.547E-2
2.787E-1
 2 92
27 hsa-let-7e*:mirSVR highEffct hsa-let-7e*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.235E-4 1.157E-2
8.148E-2
3.356E-1
 2 101
28 TGAGATT,MIR-216:MSigDB TGAGATT,MIR-216:MSigDB MSigDB 5.235E-4 1.157E-2
8.148E-2
3.356E-1
 2 101
29 hsa-miR-1306:mirSVR highEffct hsa-miR-1306:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.235E-4 1.157E-2
8.148E-2
3.356E-1
 2 101
30 hsa-miR-151-3p:PITA hsa-miR-151-3p:PITA TOP PITA 5.656E-4 1.202E-2
8.465E-2
3.625E-1
 2 105
31 hsa-miR-3147:mirSVR highEffct hsa-miR-3147:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.814E-4 1.202E-2
8.465E-2
3.727E-1
 3 495
32 hsa-miR-1269:PITA hsa-miR-1269:PITA TOP PITA 6.894E-4 1.381E-2
9.723E-2
4.419E-1
 2 116
33 hsa-miR-4251:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.496E-4 1.456E-2
1.025E-1
4.805E-1
 2 121
34 hsa-miR-556-5p:PITA hsa-miR-556-5p:PITA TOP PITA 8.774E-4 1.654E-2
1.165E-1
5.624E-1
 2 131
35 hsa-miR-558:PITA hsa-miR-558:PITA TOP PITA 1.087E-3 1.991E-2
1.402E-1
6.970E-1
 2 146
36 hsa-miR-197:PITA hsa-miR-197:PITA TOP PITA 1.177E-3 2.097E-2
1.476E-1
7.548E-1
 2 152
37 hsa-miR-22-3p:Functional MTI Functional MTI miRTarbase 1.352E-3 2.280E-2
1.605E-1
8.664E-1
 2 163
38 GCATTTG,MIR-105:MSigDB GCATTTG,MIR-105:MSigDB MSigDB 1.352E-3 2.280E-2
1.605E-1
8.664E-1
 2 163
39 hsa-miR-342-3p:PITA hsa-miR-342-3p:PITA TOP PITA 1.418E-3 2.326E-2
1.638E-1
9.089E-1
 2 167
40 hsa-miR-466:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.452E-3 2.326E-2
1.638E-1
9.305E-1
 2 169
41 hsa-miR-210:mirSVR highEffct hsa-miR-210:mirSVR conserved highEffect-0.5 MicroRNA.org 1.905E-3 2.978E-2
2.097E-1
1.000E0
 2 194
42 GAGACGG,MIR-340:MSigDB GAGACGG,MIR-340:MSigDB MSigDB 1.992E-3 3.040E-2
2.140E-1
1.000E0
 1 6
43 ACTGCCT,MIR-34B:MSigDB ACTGCCT,MIR-34B:MSigDB MSigDB 2.123E-3 3.164E-2
2.228E-1
1.000E0
 2 205
44 hsa-miR-5580-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.225E-3 3.242E-2
2.283E-1
1.000E0
 2 210
45 CCTGCTG,MIR-214:MSigDB CCTGCTG,MIR-214:MSigDB MSigDB 2.438E-3 3.473E-2
2.445E-1
1.000E0
 2 220
46 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 2.820E-3 3.751E-2
2.641E-1
1.000E0
 2 237
47 hsa-miR-34c-3p:PITA hsa-miR-34c-3p:PITA TOP PITA 2.820E-3 3.751E-2
2.641E-1
1.000E0
 2 237
48 hsa-miR-1184:PITA hsa-miR-1184:PITA TOP PITA 2.867E-3 3.751E-2
2.641E-1
1.000E0
 2 239
49 hsa-miR-874-3p:TargetScan hsa-miR-874-3p TargetScan 2.867E-3 3.751E-2
2.641E-1
1.000E0
 2 239
50 hsa-miR-3148:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.986E-3 3.828E-2
2.695E-1
1.000E0
 2 244
Show 45 more annotations

17: Drug [Display Chart] 24 input genes in category / 6689 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000068848 mesulergine Stitch 2.136E-39 1.429E-35 1.341E-34 1.429E-35 15 31
2 CID000004847 pirenperone Stitch 7.365E-39 2.463E-35 2.312E-34 4.926E-35 15 33
3 CID000003251 NSC95090 Stitch 2.849E-37 5.444E-34 5.110E-33 1.906E-33 15 40
4 CID004210613 NSC169490 Stitch 3.256E-37 5.444E-34 5.110E-33 2.178E-33 14 27
5 CID000003964 loxapine Stitch 3.616E-36 4.838E-33 4.541E-32 2.419E-32 15 46
6 CID000001832 5-MeODMT Stitch 5.310E-36 5.074E-33 4.762E-32 3.552E-32 15 47
7 CID000004431 NAN-190 Stitch 5.310E-36 5.074E-33 4.762E-32 3.552E-32 15 47
8 DB00248 Cabergoline Drug Bank 2.927E-35 2.447E-32 2.297E-31 1.958E-31 12 15
9 CID000003981 AC1L1H5B Stitch 3.776E-35 2.807E-32 2.634E-31 2.526E-31 16 77
10 CID000005011 quipazine Stitch 1.144E-34 7.655E-32 7.184E-31 7.655E-31 15 56
11 CID000005454 T15550 Stitch 3.502E-34 2.129E-31 1.998E-30 2.342E-30 13 26
12 CID000005074 ritanserin Stitch 4.957E-34 2.763E-31 2.594E-30 3.316E-30 15 61
13 CID000163091 Saphris Stitch 5.687E-34 2.926E-31 2.746E-30 3.804E-30 14 41
14 CID000005268 spiroxatrine Stitch 8.527E-34 3.825E-31 3.590E-30 5.704E-30 14 42
15 CID000008404 tetralin Stitch 8.577E-34 3.825E-31 3.590E-30 5.737E-30 15 63
16 DB01200 Bromocriptine Drug Bank 1.192E-33 4.956E-31 4.651E-30 7.976E-30 12 18
17 CID000003067 NSC407316 Stitch 1.259E-33 4.956E-31 4.651E-30 8.424E-30 13 28
18 CID000003938 S-(-)-Lisuride Stitch 1.455E-33 5.123E-31 4.808E-30 9.734E-30 15 65
19 CID000035781 5,7-dihydroxytryptamine Stitch 1.455E-33 5.123E-31 4.808E-30 9.734E-30 15 65
20 CID000004090 AC1L1HE1 Stitch 2.425E-33 8.109E-31 7.611E-30 1.622E-29 15 67
21 CID000060785 RP 62203 Stitch 3.235E-33 1.030E-30 9.671E-30 2.164E-29 12 19
22 CID000005736 zotepine Stitch 1.086E-32 3.303E-30 3.100E-29 7.266E-29 14 49
23 CID000060858 M100907 Stitch 2.078E-32 6.043E-30 5.671E-29 1.390E-28 14 51
24 CID000004106 methiothepin Stitch 2.465E-32 6.869E-30 6.447E-29 1.649E-28 15 77
25 DB00413 Pramipexole Drug Bank 4.112E-32 9.904E-30 9.295E-29 2.750E-28 11 14
26 DB00589 Lisuride Drug Bank 4.112E-32 9.904E-30 9.295E-29 2.750E-28 11 14
27 DB00268 Ropinirole Drug Bank 4.112E-32 9.904E-30 9.295E-29 2.750E-28 11 14
28 CID000068604 setoperone Stitch 4.146E-32 9.904E-30 9.295E-29 2.773E-28 12 22
29 CID000002477 buspirone Stitch 4.631E-32 1.068E-29 1.002E-28 3.098E-28 15 80
30 CID000023897 molindone Stitch 7.745E-32 1.727E-29 1.621E-28 5.181E-28 13 36
31 CID000004168 metoclopramide Stitch 1.032E-31 2.227E-29 2.090E-28 6.903E-28 15 84
32 CID000005002 quetiapine Stitch 1.234E-31 2.501E-29 2.347E-28 8.252E-28 14 57
33 CID000002820 norclozapine Stitch 1.234E-31 2.501E-29 2.347E-28 8.252E-28 14 57
34 CID000004652 p-chlorophenylalanine Stitch 1.517E-31 2.945E-29 2.764E-28 1.015E-27 15 86
35 DB00714 Apomorphine Drug Bank 1.541E-31 2.945E-29 2.764E-28 1.031E-27 11 15
36 CID000004830 pipamperone Stitch 1.813E-31 3.312E-29 3.109E-28 1.213E-27 13 38
37 CID000004184 mianserin Stitch 1.832E-31 3.312E-29 3.109E-28 1.226E-27 15 87
38 DB00246 Ziprasidone Drug Bank 3.329E-31 5.567E-29 5.225E-28 2.227E-27 12 25
39 DB01238 Aripiprazole Drug Bank 3.329E-31 5.567E-29 5.225E-28 2.227E-27 12 25
40 DB00334 Olanzapine Drug Bank 3.329E-31 5.567E-29 5.225E-28 2.227E-27 12 25
41 DB01224 Quetiapine Drug Bank 6.180E-31 1.008E-28 9.462E-28 4.134E-27 12 26
42 CID000002913 cyproheptadine Stitch 9.075E-31 1.445E-28 1.356E-27 6.070E-27 15 96
43 CID000004688 pargyline Stitch 1.073E-30 1.669E-28 1.567E-27 7.178E-27 15 97
44 CID003083577 ergolines Stitch 1.112E-30 1.690E-28 1.586E-27 7.437E-27 12 27
45 DB01186 Pergolide Drug Bank 1.396E-30 2.075E-28 1.947E-27 9.337E-27 11 17
46 CID000000144 5-HTP Stitch 2.060E-30 2.996E-28 2.812E-27 1.378E-26 15 101
47 CID000027833 EEDQ Stitch 4.762E-30 6.777E-28 6.360E-27 3.185E-26 14 72
48 CID000005265 spiperone Stitch 6.048E-30 8.428E-28 7.910E-27 4.045E-26 15 108
49 CID000003250 Ergot Stitch 6.432E-30 8.780E-28 8.240E-27 4.302E-26 13 48
50 CID000126769 SB 200646A Stitch 8.515E-30 1.139E-27 1.069E-26 5.696E-26 11 19
Show 45 more annotations

18: Disease [Display Chart] 23 input genes in category / 462 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0525045 Mood Disorders DisGeNET Curated 5.263E-19 2.431E-16 1.632E-15 2.431E-16 14 313
2 C0033975 Psychotic Disorders DisGeNET Curated 3.595E-17 8.305E-15 5.576E-14 1.661E-14 13 311
3 C0001973 Alcoholic Intoxication, Chronic DisGeNET Curated 4.879E-14 7.514E-12 5.045E-11 2.254E-11 12 402
4 C0564567 Impulsive character (finding) DisGeNET BeFree 1.317E-13 1.521E-11 1.021E-10 6.084E-11 7 43
5 C1263846 Attention deficit hyperactivity disorder DisGeNET Curated 3.511E-13 3.244E-11 2.178E-10 1.622E-10 11 343
6 C0019337 Heroin Dependence DisGeNET Curated 1.213E-12 7.983E-11 5.360E-10 5.604E-10 7 58
7 C2700439 MAJOR AFFECTIVE DISORDER 8 DisGeNET Curated 1.555E-12 7.983E-11 5.360E-10 7.185E-10 7 60
8 C2700438 MAJOR AFFECTIVE DISORDER 7 DisGeNET Curated 1.555E-12 7.983E-11 5.360E-10 7.185E-10 7 60
9 C2700440 MAJOR AFFECTIVE DISORDER 9 DisGeNET Curated 1.555E-12 7.983E-11 5.360E-10 7.185E-10 7 60
10 C0041696 Unipolar Depression DisGeNET Curated 3.022E-12 1.396E-10 9.373E-10 1.396E-9 11 418
11 C0038586 Substance Use Disorders DisGeNET Curated 5.268E-12 2.086E-10 1.401E-9 2.434E-9 6 34
12 C1970945 MAJOR AFFECTIVE DISORDER 6 DisGeNET Curated 5.871E-12 2.086E-10 1.401E-9 2.712E-9 7 72
13 C1970943 MAJOR AFFECTIVE DISORDER 4 DisGeNET Curated 5.871E-12 2.086E-10 1.401E-9 2.712E-9 7 72
14 C1852197 MAJOR AFFECTIVE DISORDER 1 DisGeNET Curated 7.889E-12 2.430E-10 1.631E-9 3.645E-9 7 75
15 C0236733 Amphetamine-Related Disorders DisGeNET Curated 7.889E-12 2.430E-10 1.631E-9 3.645E-9 7 75
16 C0349204 Nonorganic psychosis DisGeNET Curated 9.600E-12 2.772E-10 1.861E-9 4.435E-9 9 221
17 C0149931 Migraine Disorders DisGeNET Curated 2.250E-11 6.116E-10 4.106E-9 1.040E-8 9 243
18 C0233514 Abnormal behavior DisGeNET Curated 2.621E-11 6.728E-10 4.517E-9 1.211E-8 10 365
19 C3714760 Drug-induced tardive dyskinesia DisGeNET BeFree 6.136E-11 1.350E-9 9.063E-9 2.835E-8 6 50
20 C0686347 Tardive Dyskinesia DisGeNET BeFree 6.136E-11 1.350E-9 9.063E-9 2.835E-8 6 50
21 C0740858 Substance abuse problem DisGeNET Curated 6.136E-11 1.350E-9 9.063E-9 2.835E-8 6 50
22 C1839839 MAJOR AFFECTIVE DISORDER 2 DisGeNET Curated 7.170E-11 1.506E-9 1.011E-8 3.313E-8 7 102
23 C0006012 Borderline Personality Disorder DisGeNET BeFree 1.150E-10 2.310E-9 1.551E-8 5.313E-8 7 109
24 C0013146 Drug abuse DisGeNET BeFree 2.412E-10 4.642E-9 3.117E-8 1.114E-7 7 121
25 C0004936 Mental disorders DisGeNET Curated 2.689E-10 4.969E-9 3.336E-8 1.242E-7 9 321
26 C1510472 Drug Dependence DisGeNET BeFree 2.859E-10 5.080E-9 3.410E-8 1.321E-7 6 64
27 C0600427 Cocaine Dependence DisGeNET Curated 3.795E-10 6.493E-9 4.359E-8 1.753E-7 6 67
28 C0030662 Gambling, Pathological DisGeNET BeFree 1.011E-9 1.668E-8 1.120E-7 4.669E-7 4 11
29 C0003469 Anxiety Disorders DisGeNET Curated 1.249E-9 1.990E-8 1.336E-7 5.770E-7 9 382
30 C2267227 Bulimia Nervosa DisGeNET Curated 1.530E-9 2.356E-8 1.582E-7 7.068E-7 5 37
31 C0040517 Gilles de la Tourette syndrome DisGeNET Curated 2.480E-9 3.696E-8 2.482E-7 1.146E-6 6 91
32 C0025261 Memory Disorders DisGeNET Curated 2.972E-9 4.291E-8 2.881E-7 1.373E-6 5 42
33 C1510586 Autism Spectrum Disorders DisGeNET Curated 3.980E-9 5.572E-8 3.741E-7 1.839E-6 9 436
34 C0871189 Psychotic symptom DisGeNET BeFree 4.771E-9 6.483E-8 4.353E-7 2.204E-6 5 46
35 C0028768 Obsessive-Compulsive Disorder DisGeNET Curated 5.263E-9 6.947E-8 4.664E-7 2.432E-6 6 103
36 C0236736 Cocaine-Related Disorders DisGeNET Curated 7.012E-9 8.933E-8 5.998E-7 3.240E-6 6 108
37 C0013386 Dyskinesia, Drug-Induced DisGeNET Curated 7.248E-9 8.933E-8 5.998E-7 3.349E-6 4 17
38 C0338480 Common Migraine DisGeNET Curated 7.348E-9 8.933E-8 5.998E-7 3.395E-6 5 50
39 C0028043 Nicotine Dependence DisGeNET BeFree 1.079E-8 1.279E-7 8.585E-7 4.987E-6 6 116
40 C0149654 Conduct Disorder DisGeNET BeFree 1.471E-8 1.658E-7 1.113E-6 6.798E-6 4 20
41 C0021122 Disruptive, Impulse Control, and Conduct Disorders DisGeNET Curated 1.471E-8 1.658E-7 1.113E-6 6.798E-6 4 20
42 C0036939 Shared Paranoid Disorder DisGeNET Curated 1.816E-8 1.998E-7 1.341E-6 8.390E-6 4 21
43 C0006370 Bulimia DisGeNET BeFree 2.217E-8 2.382E-7 1.600E-6 1.024E-5 4 22
44 C0013384 Dyskinetic syndrome DisGeNET Curated 2.408E-8 2.529E-7 1.698E-6 1.113E-5 5 63
45 C0009171 Cocaine Abuse DisGeNET Curated 2.682E-8 2.698E-7 1.811E-6 1.239E-5 4 23
46 C0086132 Depressive Symptoms DisGeNET Curated 2.686E-8 2.698E-7 1.811E-6 1.241E-5 6 135
47 C0024517 Single major depressive episode DisGeNET Curated 3.824E-8 3.759E-7 2.524E-6 1.767E-5 4 25
48 C0036337 Schizoaffective Disorder DisGeNET Curated 4.120E-8 3.966E-7 2.662E-6 1.903E-5 5 70
49 C0085762 Alcohol abuse DisGeNET Curated 7.133E-8 6.726E-7 4.516E-6 3.296E-5 5 78
50 C0003467 Anxiety DisGeNET Curated 8.251E-8 7.624E-7 5.118E-6 3.812E-5 8 432
Show 45 more annotations