Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc403_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 35 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008022 protein C-terminus binding 4.909E-9 1.718E-7 7.124E-7 1.718E-7 5 224
2 GO:0004385 guanylate kinase activity 1.174E-8 2.055E-7 8.522E-7 4.110E-7 3 14
3 GO:0030165 PDZ domain binding 4.559E-8 5.318E-7 2.205E-6 1.596E-6 4 114
4 GO:0035255 ionotropic glutamate receptor binding 8.372E-8 7.326E-7 3.038E-6 2.930E-6 3 26
5 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4.252E-7 2.842E-6 1.179E-5 1.488E-5 3 44
6 GO:0035254 glutamate receptor binding 4.872E-7 2.842E-6 1.179E-5 1.705E-5 3 46
7 GO:0019205 nucleobase-containing compound kinase activity 9.375E-7 4.688E-6 1.944E-5 3.281E-5 3 57
8 GO:0032947 protein-containing complex scaffold activity 2.429E-6 1.063E-5 4.407E-5 8.503E-5 3 78
9 GO:0019902 phosphatase binding 3.365E-5 1.309E-4 5.426E-4 1.178E-3 3 187
10 GO:0044325 ion channel binding 9.437E-4 3.196E-3 1.325E-2 3.303E-2 2 127
11 GO:0097016 L27 domain binding 1.125E-3 3.196E-3 1.325E-2 3.937E-2 1 3
12 GO:0019903 protein phosphatase binding 1.178E-3 3.196E-3 1.325E-2 4.122E-2 2 142
13 GO:0022834 ligand-gated channel activity 1.278E-3 3.196E-3 1.325E-2 4.474E-2 2 148
14 GO:0015276 ligand-gated ion channel activity 1.278E-3 3.196E-3 1.325E-2 4.474E-2 2 148
15 GO:0022836 gated channel activity 6.210E-3 1.449E-2
6.009E-2
2.174E-1
 2 331
16 GO:0031434 mitogen-activated protein kinase kinase binding 7.107E-3 1.555E-2
6.446E-2
2.487E-1
 1 19
17 GO:0051393 alpha-actinin binding 9.342E-3 1.847E-2
7.660E-2
3.270E-1
 1 25
18 GO:0030159 receptor signaling complex scaffold activity 9.714E-3 1.847E-2
7.660E-2
3.400E-1
 1 26
19 GO:0005216 ion channel activity 1.003E-2 1.847E-2
7.660E-2
3.510E-1
 2 424
20 GO:0022838 substrate-specific channel activity 1.068E-2 1.868E-2
7.747E-2
3.736E-1
 2 438
21 GO:0015267 channel activity 1.222E-2 1.953E-2
8.097E-2
4.278E-1
 2 470
22 GO:0022803 passive transmembrane transporter activity 1.227E-2 1.953E-2
8.097E-2
4.296E-1
 2 471
23 GO:0042805 actinin binding 1.343E-2 2.043E-2
8.474E-2
4.700E-1
 1 36
24 GO:0005109 frizzled binding 1.417E-2 2.066E-2
8.569E-2
4.959E-1
 1 38
25 GO:0015459 potassium channel regulator activity 1.787E-2 2.502E-2
1.037E-1
6.254E-1
 1 48
26 GO:0008013 beta-catenin binding 3.292E-2 4.431E-2
1.837E-1
1.000E0
 1 89
Show 21 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 286 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 2.261E-13 6.467E-11 4.032E-10 6.467E-11 5 32
2 GO:0035088 establishment or maintenance of apical/basal cell polarity 7.383E-13 7.039E-11 4.389E-10 2.112E-10 5 40
3 GO:0061245 establishment or maintenance of bipolar cell polarity 7.383E-13 7.039E-11 4.389E-10 2.112E-10 5 40
4 GO:0007163 establishment or maintenance of cell polarity 1.696E-9 1.213E-7 7.563E-7 4.852E-7 5 181
5 GO:0097120 receptor localization to synapse 7.144E-9 4.086E-7 2.548E-6 2.043E-6 3 12
6 GO:0046710 GDP metabolic process 9.286E-9 4.426E-7 2.760E-6 2.656E-6 3 13
7 GO:0046037 GMP metabolic process 3.697E-8 1.511E-6 9.418E-6 1.057E-5 3 20
8 GO:0035418 protein localization to synapse 1.061E-7 3.793E-6 2.365E-5 3.035E-5 3 28
9 GO:1901068 guanosine-containing compound metabolic process 5.584E-7 1.774E-5 1.106E-4 1.597E-4 3 48
10 GO:0043113 receptor clustering 7.557E-7 2.161E-5 1.348E-4 2.161E-4 3 53
11 GO:0009135 purine nucleoside diphosphate metabolic process 5.334E-6 1.271E-4 7.927E-4 1.526E-3 3 101
12 GO:0009179 purine ribonucleoside diphosphate metabolic process 5.334E-6 1.271E-4 7.927E-4 1.526E-3 3 101
13 GO:0009185 ribonucleoside diphosphate metabolic process 6.170E-6 1.357E-4 8.464E-4 1.765E-3 3 106
14 GO:0045176 apical protein localization 9.428E-6 1.926E-4 1.201E-3 2.696E-3 2 13
15 GO:0009132 nucleoside diphosphate metabolic process 1.038E-5 1.979E-4 1.234E-3 2.968E-3 3 126
16 GO:0051668 localization within membrane 1.364E-5 2.437E-4 1.520E-3 3.900E-3 3 138
17 GO:0072659 protein localization to plasma membrane 5.877E-5 9.587E-4 5.977E-3 1.681E-2 3 225
18 GO:1990778 protein localization to cell periphery 6.034E-5 9.587E-4 5.977E-3 1.726E-2 3 227
19 GO:0009167 purine ribonucleoside monophosphate metabolic process 1.114E-4 1.609E-3 1.003E-2 3.185E-2 3 279
20 GO:0009126 purine nucleoside monophosphate metabolic process 1.125E-4 1.609E-3 1.003E-2 3.219E-2 3 280
21 GO:0007009 plasma membrane organization 1.262E-4 1.640E-3 1.023E-2 3.608E-2 3 291
22 GO:0009161 ribonucleoside monophosphate metabolic process 1.262E-4 1.640E-3 1.023E-2 3.608E-2 3 291
23 GO:0009123 nucleoside monophosphate metabolic process 1.436E-4 1.786E-3 1.113E-2 4.107E-2 3 304
24 GO:0043297 apical junction assembly 1.982E-4 2.362E-3 1.473E-2
5.668E-2
 2 58
25 GO:0006470 protein dephosphorylation 2.070E-4 2.368E-3 1.476E-2
5.919E-2
 3 344
26 GO:0046128 purine ribonucleoside metabolic process 2.386E-4 2.590E-3 1.615E-2
6.824E-2
 3 361
27 GO:0042278 purine nucleoside metabolic process 2.445E-4 2.590E-3 1.615E-2
6.993E-2
 3 364
28 GO:1904375 regulation of protein localization to cell periphery 2.973E-4 2.768E-3 1.726E-2
8.502E-2
 2 71
29 GO:1903076 regulation of protein localization to plasma membrane 2.973E-4 2.768E-3 1.726E-2
8.502E-2
 2 71
30 GO:0009119 ribonucleoside metabolic process 3.019E-4 2.768E-3 1.726E-2
8.634E-2
 3 391
31 GO:0010923 negative regulation of phosphatase activity 3.057E-4 2.768E-3 1.726E-2
8.743E-2
 2 72
32 GO:0009116 nucleoside metabolic process 3.546E-4 2.768E-3 1.726E-2
1.014E-1
 3 413
33 GO:0035308 negative regulation of protein dephosphorylation 3.588E-4 2.768E-3 1.726E-2
1.026E-1
 2 78
34 GO:0045186 zonula adherens assembly 3.759E-4 2.768E-3 1.726E-2
1.075E-1
 1 1
35 GO:0043002 negative regulation of Golgi to plasma membrane CFTR protein transport 3.759E-4 2.768E-3 1.726E-2
1.075E-1
 1 1
36 GO:0042999 regulation of Golgi to plasma membrane CFTR protein transport 3.759E-4 2.768E-3 1.726E-2
1.075E-1
 1 1
37 GO:0043004 cytoplasmic sequestering of CFTR protein 3.759E-4 2.768E-3 1.726E-2
1.075E-1
 1 1
38 GO:1903729 regulation of plasma membrane organization 3.774E-4 2.768E-3 1.726E-2
1.079E-1
 2 80
39 GO:0035305 negative regulation of dephosphorylation 3.774E-4 2.768E-3 1.726E-2
1.079E-1
 2 80
40 GO:1901657 glycosyl compound metabolic process 4.131E-4 2.953E-3 1.841E-2
1.181E-1
 3 435
41 GO:0016311 dephosphorylation 4.416E-4 3.080E-3 1.920E-2
1.263E-1
 3 445
42 GO:0007043 cell-cell junction assembly 5.318E-4 3.621E-3 2.258E-2
1.521E-1
 2 95
43 GO:0043000 Golgi to plasma membrane CFTR protein transport 7.516E-4 4.999E-3 3.117E-2
2.150E-1
 1 2
44 GO:0010921 regulation of phosphatase activity 1.101E-3 7.158E-3 4.463E-2
3.150E-1
 2 137
45 GO:0001738 morphogenesis of a polarized epithelium 1.166E-3 7.410E-3 4.620E-2
3.335E-1
 2 141
46 GO:0043622 cortical microtubule organization 1.503E-3 8.672E-3
5.407E-2
4.298E-1
 1 4
47 GO:0051660 establishment of centrosome localization 1.503E-3 8.672E-3
5.407E-2
4.298E-1
 1 4
48 GO:0071896 protein localization to adherens junction 1.503E-3 8.672E-3
5.407E-2
4.298E-1
 1 4
49 GO:1903753 negative regulation of p38MAPK cascade 1.503E-3 8.672E-3
5.407E-2
4.298E-1
 1 4
50 GO:0035304 regulation of protein dephosphorylation 1.516E-3 8.672E-3
5.407E-2
4.336E-1
 2 161
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 65 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045211 postsynaptic membrane 4.517E-9 1.141E-7 5.432E-7 2.936E-7 5 225
2 GO:0014069 postsynaptic density 5.268E-9 1.141E-7 5.432E-7 3.424E-7 5 232
3 GO:0099572 postsynaptic specialization 5.268E-9 1.141E-7 5.432E-7 3.424E-7 5 232
4 GO:0060076 excitatory synapse 7.979E-9 1.297E-7 6.171E-7 5.186E-7 5 252
5 GO:0097060 synaptic membrane 1.849E-8 2.404E-7 1.144E-6 1.202E-6 5 298
6 GO:0005923 bicellular tight junction 4.339E-8 4.471E-7 2.128E-6 2.821E-6 4 115
7 GO:0070160 tight junction 4.815E-8 4.471E-7 2.128E-6 3.130E-6 4 118
8 GO:0043296 apical junction complex 7.340E-8 5.963E-7 2.838E-6 4.771E-6 4 131
9 GO:0005911 cell-cell junction 1.003E-7 7.245E-7 3.448E-6 6.520E-6 5 418
10 GO:0098794 postsynapse 1.433E-7 9.314E-7 4.433E-6 9.314E-6 5 449
11 GO:0008328 ionotropic glutamate receptor complex 5.901E-7 3.487E-6 1.659E-5 3.835E-5 3 50
12 GO:0016323 basolateral plasma membrane 8.897E-7 4.819E-6 2.294E-5 5.783E-5 4 244
13 GO:0098802 plasma membrane receptor complex 2.819E-5 1.410E-4 6.708E-4 1.832E-3 3 180
14 GO:0034702 ion channel complex 1.178E-4 5.469E-4 2.603E-3 7.656E-3 3 291
15 GO:1902495 transmembrane transporter complex 1.664E-4 7.076E-4 3.368E-3 1.081E-2 3 327
16 GO:1990351 transporter complex 1.756E-4 7.076E-4 3.368E-3 1.141E-2 3 333
17 GO:0043235 receptor complex 1.851E-4 7.076E-4 3.368E-3 1.203E-2 3 339
18 GO:0005913 cell-cell adherens junction 2.603E-4 9.401E-4 4.474E-3 1.692E-2 2 68
19 GO:0044304 main axon 3.083E-4 1.055E-3 5.020E-3 2.004E-2 2 74
20 GO:0005912 adherens junction 5.277E-4 1.715E-3 8.163E-3 3.430E-2 3 484
21 GO:0097025 MPP7-DLG1-LIN7 complex 1.101E-3 3.409E-3 1.622E-2
7.159E-2
 1 3
22 GO:0043219 lateral loop 2.568E-3 7.588E-3 3.611E-2
1.669E-1
 1 7
23 GO:0035748 myelin sheath abaxonal region 3.301E-3 9.329E-3 4.440E-2
2.146E-1
 1 9
24 GO:0044224 juxtaparanode region of axon 3.667E-3 9.932E-3 4.727E-2
2.384E-1
 1 10
25 GO:0033267 axon part 5.213E-3 1.355E-2
6.450E-2
3.388E-1
 2 309
26 GO:0033270 paranode region of axon 5.497E-3 1.374E-2
6.540E-2
3.573E-1
 1 15
27 GO:0033268 node of Ranvier 5.862E-3 1.411E-2
6.716E-2
3.810E-1
 1 16
28 GO:0098793 presynapse 6.315E-3 1.466E-2
6.977E-2
4.105E-1
 2 341
29 GO:0030140 trans-Golgi network transport vesicle 1.097E-2 2.376E-2
1.131E-1
7.129E-1
 1 30
30 GO:0032281 AMPA glutamate receptor complex 1.097E-2 2.376E-2
1.131E-1
7.129E-1
 1 30
31 GO:0001772 immunological synapse 1.278E-2 2.681E-2
1.276E-1
8.310E-1
 1 35
32 GO:0009925 basal plasma membrane 1.569E-2 3.187E-2
1.517E-1
1.000E0
 1 43
33 GO:0030660 Golgi-associated vesicle membrane 1.931E-2 3.691E-2
1.757E-1
1.000E0
 1 53
34 GO:0016328 lateral plasma membrane 1.931E-2 3.691E-2
1.757E-1
1.000E0
 1 53
35 GO:0014704 intercalated disc 2.111E-2 3.734E-2
1.777E-1
1.000E0
 1 58
36 GO:0031594 neuromuscular junction 2.183E-2 3.734E-2
1.777E-1
1.000E0
 1 60
37 GO:0043198 dendritic shaft 2.183E-2 3.734E-2
1.777E-1
1.000E0
 1 60
38 GO:0030315 T-tubule 2.183E-2 3.734E-2
1.777E-1
1.000E0
 1 60
39 GO:0045178 basal part of cell 2.327E-2 3.879E-2
1.846E-1
1.000E0
 1 64
40 GO:0044291 cell-cell contact zone 2.579E-2 4.191E-2
1.994E-1
1.000E0
 1 71
41 GO:0042734 presynaptic membrane 2.758E-2 4.373E-2
2.081E-1
1.000E0
 1 76
42 GO:0005798 Golgi-associated vesicle 3.116E-2 4.823E-2
2.295E-1
1.000E0
 1 86
43 GO:0005902 microvillus 3.224E-2 4.862E-2
2.314E-1
1.000E0
 1 89
44 GO:0008076 voltage-gated potassium channel complex 3.331E-2 4.862E-2
2.314E-1
1.000E0
 1 92
45 GO:0034705 potassium channel complex 3.366E-2 4.862E-2
2.314E-1
1.000E0
 1 93
Show 40 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 174 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 6 input genes in category / 211 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002910 abnormal excitatory postsynaptic currents 5.324E-5 1.123E-2
6.663E-2
 1.123E-2 3 146
2 MP:0004860 dilated kidney collecting duct 1.466E-4 1.546E-2
9.171E-2
 3.092E-2 2 33
3 MP:0003847 disorganized lens bow 5.794E-4 3.705E-2
2.198E-1
1.223E-1
 1 1
4 MP:0004754 abnormal kidney collecting duct morphology 7.024E-4 3.705E-2
2.198E-1
1.482E-1
 2 72
5 MP:0009084 blind uterus 1.159E-3 4.071E-2
2.415E-1
2.445E-1
 1 2
6 MP:0000534 abnormal ureter morphology 1.631E-3 4.071E-2
2.415E-1
3.442E-1
 2 110
7 MP:0003535 absent vagina 1.737E-3 4.071E-2
2.415E-1
3.666E-1
 1 3
8 MP:0001035 abnormal submandibular ganglion morphology 1.737E-3 4.071E-2
2.415E-1
3.666E-1
 1 3
9 MP:0011484 abnormal ureter urothelium morphology 2.316E-3 4.071E-2
2.415E-1
4.887E-1
 1 4
10 MP:0011273 prolonged excitatory postsynaptic current decay time 2.316E-3 4.071E-2
2.415E-1
4.887E-1
 1 4
11 MP:0003588 ureter stenosis 2.316E-3 4.071E-2
2.415E-1
4.887E-1
 1 4
12 MP:0011298 ureter hypoplasia 2.894E-3 4.071E-2
2.415E-1
6.107E-1
 1 5
13 MP:0011331 abnormal papillary duct morphology 2.894E-3 4.071E-2
2.415E-1
6.107E-1
 1 5
14 MP:0008796 increased lens fiber apoptosis 2.894E-3 4.071E-2
2.415E-1
6.107E-1
 1 5
15 MP:0008795 abnormal lens fiber apoptosis 2.894E-3 4.071E-2
2.415E-1
6.107E-1
 1 5
16 MP:0011480 impaired ureteric peristalsis 3.472E-3 4.579E-2
2.716E-1
7.327E-1
 1 6
17 MP:0011365 small metanephros 4.050E-3 4.650E-2
2.758E-1
8.546E-1
 1 7
18 MP:0003585 large ureter 4.050E-3 4.650E-2
2.758E-1
8.546E-1
 1 7
19 MP:0004871 premaxilla hypoplasia 4.628E-3 4.650E-2
2.758E-1
9.764E-1
 1 8
20 MP:0008794 increased lens epithelium apoptosis 4.628E-3 4.650E-2
2.758E-1
9.764E-1
 1 8
21 MP:0008793 abnormal lens epithelium apoptosis 4.628E-3 4.650E-2
2.758E-1
9.764E-1
 1 8
22 MP:0002990 short ureter 5.205E-3 4.775E-2
2.832E-1
1.000E0
 1 9
23 MP:0011727 ectopic ovary 5.205E-3 4.775E-2
2.832E-1
1.000E0
 1 9
24 MP:0020066 abnormal neocortex size 5.782E-3 4.880E-2
2.894E-1
1.000E0
 1 10
25 MP:0003589 abnormal ureter physiology 5.782E-3 4.880E-2
2.894E-1
1.000E0
 1 10
Show 20 more annotations

6: Domain [Display Chart] 7 input genes in category / 43 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00595 PDZ Pfam 1.177E-15 1.732E-14 7.532E-14 5.061E-14 7 141
2 SM00228 PDZ SMART 1.664E-15 1.732E-14 7.532E-14 7.156E-14 7 148
3 2.30.42.10 - Gene3D 1.832E-15 1.732E-14 7.532E-14 7.876E-14 7 150
4 PS50106 PDZ PROSITE 1.921E-15 1.732E-14 7.532E-14 8.259E-14 7 151
5 IPR001478 PDZ InterPro 2.013E-15 1.732E-14 7.532E-14 8.658E-14 7 152
6 PS00856 GUANYLATE KINASE 1 PROSITE 3.670E-14 2.254E-13 9.806E-13 1.578E-12 5 23
7 PS50052 GUANYLATE KINASE 2 PROSITE 3.670E-14 2.254E-13 9.806E-13 1.578E-12 5 23
8 IPR008144 Guanylate kin-like dom InterPro 7.172E-14 2.804E-13 1.220E-12 3.084E-12 5 26
9 SM00072 GuKc SMART 7.172E-14 2.804E-13 1.220E-12 3.084E-12 5 26
10 IPR008145 GK/Ca channel bsu InterPro 7.172E-14 2.804E-13 1.220E-12 3.084E-12 5 26
11 PF00625 Guanylate kin Pfam 7.172E-14 2.804E-13 1.220E-12 3.084E-12 5 26
12 IPR020590 Guanylate kinase CS InterPro 1.239E-11 4.441E-11 1.932E-10 5.329E-10 4 16
13 IPR016313 DLG1 InterPro 1.277E-10 3.052E-10 1.327E-9 5.493E-9 3 4
14 IPR019590 DLG1 PEST dom InterPro 1.277E-10 3.052E-10 1.327E-9 5.493E-9 3 4
15 PF10600 PDZ assoc Pfam 1.277E-10 3.052E-10 1.327E-9 5.493E-9 3 4
16 PF10608 MAGUK N PEST Pfam 1.277E-10 3.052E-10 1.327E-9 5.493E-9 3 4
17 IPR019583 PDZ assoc InterPro 1.277E-10 3.052E-10 1.327E-9 5.493E-9 3 4
18 SM01277 MAGUK N PEST SMART 1.277E-10 3.052E-10 1.327E-9 5.493E-9 3 4
19 SM00326 SH3 SMART 5.963E-7 1.282E-6 5.577E-6 2.564E-5 4 217
20 PS50002 SH3 PROSITE 5.963E-7 1.282E-6 5.577E-6 2.564E-5 4 217
21 IPR001452 SH3 domain InterPro 6.415E-7 1.313E-6 5.714E-6 2.758E-5 4 221
22 IPR004172 L27 dom InterPro 9.316E-6 1.669E-5 7.260E-5 4.006E-4 2 13
23 SM00569 L27 SMART 9.316E-6 1.669E-5 7.260E-5 4.006E-4 2 13
24 PS51022 L27 PROSITE 9.316E-6 1.669E-5 7.260E-5 4.006E-4 2 13
25 PF00018 SH3 1 Pfam 2.246E-5 3.864E-5 1.681E-4 9.660E-4 3 164
26 PF09058 L27 1 Pfam 3.736E-4 5.355E-4 2.330E-3 1.607E-2 1 1
27 IPR006907 DUF622 InterPro 3.736E-4 5.355E-4 2.330E-3 1.607E-2 1 1
28 IPR030033 MAGI1 InterPro 3.736E-4 5.355E-4 2.330E-3 1.607E-2 1 1
29 PF04822 Takusan Pfam 3.736E-4 5.355E-4 2.330E-3 1.607E-2 1 1
30 IPR015143 L27 1 InterPro 3.736E-4 5.355E-4 2.330E-3 1.607E-2 1 1
31 PF07653 SH3 2 Pfam 4.409E-4 5.925E-4 2.577E-3 1.896E-2 2 87
32 IPR011511 SH3 2 InterPro 4.409E-4 5.925E-4 2.577E-3 1.896E-2 2 87
33 PF02828 L27 Pfam 3.731E-3 4.719E-3 2.053E-2
1.604E-1
 1 10
34 IPR014775 L27 C InterPro 3.731E-3 4.719E-3 2.053E-2
1.604E-1
 1 10
35 IPR001315 CARD InterPro 1.153E-2 1.416E-2
6.160E-2
4.957E-1
 1 31
36 PS50209 CARD PROSITE 1.227E-2 1.465E-2
6.374E-2
5.275E-1
 1 33
37 PF00397 WW Pfam 1.743E-2 2.014E-2
8.762E-2
7.496E-1
 1 47
38 SM00456 WW SMART 1.780E-2 2.014E-2
8.762E-2
7.654E-1
 1 48
39 PS01159 WW DOMAIN 1 PROSITE 1.890E-2 2.021E-2
8.792E-2
8.128E-1
 1 51
40 PS50020 WW DOMAIN 2 PROSITE 1.890E-2 2.021E-2
8.792E-2
8.128E-1
 1 51
41 IPR001202 WW dom InterPro 1.927E-2 2.021E-2
8.792E-2
8.286E-1
 1 52
42 1.10.533.10 - Gene3D 3.424E-2 3.506E-2
1.525E-1
1.000E0
 1 93
43 IPR011029 DEATH-like dom InterPro 3.641E-2 3.641E-2
1.584E-1
1.000E0
 1 99
Show 38 more annotations

7: Pathway [Display Chart] 6 input genes in category / 39 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1427849 Protein-protein interactions at synapses BioSystems: REACTOME 1.617E-8 6.307E-7 2.683E-6 6.307E-7 4 73
2 83071 Tight junction BioSystems: KEGG 4.928E-7 9.610E-6 4.087E-5 1.922E-5 4 170
3 1427850 Interactions of neurexins and neuroligins at synapses BioSystems: REACTOME 2.002E-6 2.602E-5 1.107E-4 7.806E-5 3 59
4 1270329 NrCAM interactions BioSystems: REACTOME 4.060E-6 3.959E-5 1.684E-4 1.584E-4 2 7
5 1268763 Neuronal System BioSystems: REACTOME 8.909E-6 6.949E-5 2.956E-4 3.474E-4 4 351
6 1268811 Activation of Ca-permeable Kainate Receptor BioSystems: REACTOME 1.275E-5 7.102E-5 3.021E-4 4.972E-4 2 12
7 1268809 Ionotropic activity of Kainate Receptors BioSystems: REACTOME 1.275E-5 7.102E-5 3.021E-4 4.972E-4 2 12
8 749777 Hippo signaling pathway BioSystems: KEGG 3.612E-5 1.754E-4 7.462E-4 1.409E-3 3 154
9 1383059 SALM protein interactions at the synapses BioSystems: REACTOME 4.048E-5 1.754E-4 7.462E-4 1.579E-3 2 21
10 1268808 Activation of Kainate Receptors upon glutamate binding BioSystems: REACTOME 9.539E-5 3.612E-4 1.536E-3 3.720E-3 2 32
11 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 1.019E-4 3.612E-4 1.536E-3 3.973E-3 3 218
12 1270323 L1CAM interactions BioSystems: REACTOME 9.759E-4 3.172E-3 1.349E-2 3.806E-2 2 102
13 1269517 RHO GTPases regulate CFTR trafficking BioSystems: REACTOME 1.445E-3 4.336E-3 1.844E-2
5.636E-2
 1 3
14 1268786 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell BioSystems: REACTOME 2.013E-3 5.609E-3 2.386E-2
7.852E-2
 2 147
15 1269520 RHO GTPases Activate Rhotekin and Rhophilins BioSystems: REACTOME 4.330E-3 1.126E-2 4.789E-2
1.689E-1
 1 9
16 1269509 RHO GTPase Effectors BioSystems: REACTOME 7.881E-3 1.921E-2
8.171E-2
3.073E-1
 2 295
17 1268772 Dopamine Neurotransmitter Release Cycle BioSystems: REACTOME 1.104E-2 2.227E-2
9.473E-2
4.304E-1
 1 23
18 1268795 Trafficking of AMPA receptors BioSystems: REACTOME 1.533E-2 2.227E-2
9.473E-2
5.977E-1
 1 32
19 1268794 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity BioSystems: REACTOME 1.533E-2 2.227E-2
9.473E-2
5.977E-1
 1 32
20 138005 E-cadherin signaling in the nascent adherens junction BioSystems: Pathway Interaction Database 1.580E-2 2.227E-2
9.473E-2
6.163E-1
 1 33
21 1269507 Signaling by Rho GTPases BioSystems: REACTOME 1.628E-2 2.227E-2
9.473E-2
6.348E-1
 2 430
22 SMP00325 Disopyramide Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
23 SMP00328 Lidocaine (Antiarrhythmic) Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
24 SMP00324 Procainamide (Antiarrhythmic) Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
25 SMP00332 Ibutilide Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
26 SMP00331 Flecainide Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
27 SMP00327 Phenytoin (Antiarrhythmic) Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
28 SMP00330 Tocainide Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
29 SMP00329 Mexiletine Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
30 SMP00323 Quinidine Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
31 SMP00326 Fosphenytoin (Antiarrhythmic) Pathway SMPDB 1.770E-2 2.227E-2
9.473E-2
6.904E-1
 1 37
32 1268768 Neurotransmitter Release Cycle BioSystems: REACTOME 2.433E-2 2.966E-2
1.261E-1
9.490E-1
 1 51
33 SMP00359 Diltiazem Pathway SMPDB 2.716E-2 3.116E-2
1.325E-1
1.000E0
 1 57
34 SMP00375 Verapamil Pathway SMPDB 2.716E-2 3.116E-2
1.325E-1
1.000E0
 1 57
35 137994 CDC42 signaling events BioSystems: Pathway Interaction Database 3.327E-2 3.707E-2
1.577E-1
1.000E0
 1 70
Show 30 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 630 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15024025 Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Pubmed 1.529E-12 9.632E-10 6.765E-9 9.632E-10 4 19
2 21031555 Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex. Pubmed 1.508E-11 3.166E-9 2.224E-8 9.499E-9 3 4
3 23201973 Synaptic scaffold evolution generated components of vertebrate cognitive complexity. Pubmed 1.508E-11 3.166E-9 2.224E-8 9.499E-9 3 4
4 11134026 Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95. Pubmed 3.769E-11 3.958E-9 2.780E-8 2.375E-8 3 5
5 15317815 PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. Pubmed 3.769E-11 3.958E-9 2.780E-8 2.375E-8 3 5
6 12713445 Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Pubmed 3.769E-11 3.958E-9 2.780E-8 2.375E-8 3 5
7 11274188 Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. Pubmed 7.538E-11 4.749E-9 3.335E-8 4.749E-8 3 6
8 12070168 Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. Pubmed 7.538E-11 4.749E-9 3.335E-8 4.749E-8 3 6
9 19118189 Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. Pubmed 7.538E-11 4.749E-9 3.335E-8 4.749E-8 3 6
10 11572861 Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. Pubmed 7.538E-11 4.749E-9 3.335E-8 4.749E-8 3 6
11 11997254 Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Pubmed 1.319E-10 6.925E-9 4.864E-8 8.309E-8 3 7
12 9753324 A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Pubmed 1.319E-10 6.925E-9 4.864E-8 8.309E-8 3 7
13 12351654 Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. Pubmed 2.110E-10 9.496E-9 6.670E-8 1.329E-7 3 8
14 16316992 Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. Pubmed 2.110E-10 9.496E-9 6.670E-8 1.329E-7 3 8
15 17938206 The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Pubmed 3.165E-10 1.329E-8 9.337E-8 1.994E-7 3 9
16 21119615 DGKι regulates presynaptic release during mGluR-dependent LTD. Pubmed 6.216E-10 2.448E-8 1.719E-7 3.916E-7 3 11
17 16980967 NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Pubmed 8.287E-10 3.071E-8 2.157E-7 5.221E-7 3 12
18 21920314 Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Pubmed 1.371E-9 4.798E-8 3.370E-7 8.637E-7 3 14
19 19455133 Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Pubmed 3.072E-9 1.019E-7 7.155E-7 1.936E-6 3 18
20 27480238 SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion. Pubmed 7.617E-9 2.285E-7 1.605E-6 4.799E-6 3 24
21 16637659 Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. Pubmed 7.617E-9 2.285E-7 1.605E-6 4.799E-6 3 24
22 18618587 Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102. Pubmed 2.879E-8 7.256E-7 5.096E-6 1.814E-5 2 2
23 27760079 Expression of DLG1 and DLG5 in the Intestinal Epithelium of Patients with CD. Pubmed 2.879E-8 7.256E-7 5.096E-6 1.814E-5 2 2
24 17267502 Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. Pubmed 2.879E-8 7.256E-7 5.096E-6 1.814E-5 2 2
25 12444549 Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins. Pubmed 2.879E-8 7.256E-7 5.096E-6 1.814E-5 2 2
26 21489588 Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
27 11571640 HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
28 12175853 Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
29 28077487 Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
30 23486974 Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
31 9677374 SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
32 25268382 Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
33 17046693 Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins. Pubmed 8.637E-8 1.649E-6 1.158E-5 5.441E-5 2 3
34 22745667 Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. Pubmed 1.041E-7 1.928E-6 1.354E-5 6.556E-5 3 56
35 12097473 Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. Pubmed 1.727E-7 2.864E-6 2.011E-5 1.088E-4 2 4
36 19586902 Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity. Pubmed 1.727E-7 2.864E-6 2.011E-5 1.088E-4 2 4
37 10595517 Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. Pubmed 1.727E-7 2.864E-6 2.011E-5 1.088E-4 2 4
38 16473877 Ggamma13 interacts with PDZ domain-containing proteins. Pubmed 1.727E-7 2.864E-6 2.011E-5 1.088E-4 2 4
39 9786987 Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Pubmed 2.879E-7 4.217E-6 2.962E-5 1.814E-4 2 5
40 9808460 SAP90 binds and clusters kainate receptors causing incomplete desensitization. Pubmed 2.879E-7 4.217E-6 2.962E-5 1.814E-4 2 5
41 17237226 The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. Pubmed 2.879E-7 4.217E-6 2.962E-5 1.814E-4 2 5
42 10725395 The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Pubmed 2.879E-7 4.217E-6 2.962E-5 1.814E-4 2 5
43 16482544 Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6. Pubmed 2.879E-7 4.217E-6 2.962E-5 1.814E-4 2 5
44 10862698 Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Pubmed 3.442E-7 4.928E-6 3.461E-5 2.168E-4 3 83
45 16495444 A novel family of adhesion-like molecules that interacts with the NMDA receptor. Pubmed 6.044E-7 7.933E-6 5.572E-5 3.808E-4 2 7
46 19243221 Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. Pubmed 6.044E-7 7.933E-6 5.572E-5 3.808E-4 2 7
47 7477295 Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Pubmed 6.044E-7 7.933E-6 5.572E-5 3.808E-4 2 7
48 9115257 SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. Pubmed 6.044E-7 7.933E-6 5.572E-5 3.808E-4 2 7
49 14960569 A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Pubmed 1.036E-6 1.231E-5 8.649E-5 6.526E-4 2 9
50 24498314 C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9. Pubmed 1.036E-6 1.231E-5 8.649E-5 6.526E-4 2 9
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 394 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ABCA1 ABCA1 interactions 3.060E-12 1.205E-9 7.901E-9 1.205E-9 5 50
2 int:KCNJ12 KCNJ12 interactions 2.613E-11 5.148E-9 3.374E-8 1.030E-8 4 18
3 int:CACNG2 CACNG2 interactions 1.497E-10 1.966E-8 1.289E-7 5.897E-8 4 27
4 int:ASIC3 ASIC3 interactions 4.538E-9 4.469E-7 2.930E-6 1.788E-6 3 10
5 int:SCN4A SCN4A interactions 6.238E-9 4.916E-7 3.222E-6 2.458E-6 3 11
6 int:KIF1B KIF1B interactions 9.225E-9 5.646E-7 3.701E-6 3.635E-6 4 73
7 int:GUCY1A2 GUCY1A2 interactions 1.081E-8 5.646E-7 3.701E-6 4.259E-6 3 13
8 int:LRP2 LRP2 interactions 1.146E-8 5.646E-7 3.701E-6 4.517E-6 4 77
9 int:KCNJ4 KCNJ4 interactions 1.719E-8 6.157E-7 4.036E-6 6.773E-6 3 15
10 int:GLS2 GLS2 interactions 1.719E-8 6.157E-7 4.036E-6 6.773E-6 3 15
11 int:KCNJ2 KCNJ2 interactions 1.719E-8 6.157E-7 4.036E-6 6.773E-6 3 15
12 int:CRIPT CRIPT interactions 2.568E-8 8.432E-7 5.527E-6 1.012E-5 3 17
13 int:GRIN2B GRIN2B interactions 2.927E-8 8.871E-7 5.815E-6 1.153E-5 4 97
14 int:SCN5A SCN5A interactions 5.811E-8 1.635E-6 1.072E-5 2.290E-5 3 22
15 int:KCNA4 KCNA4 interactions 9.805E-8 2.414E-6 1.583E-5 3.863E-5 3 26
16 int:GRIK2 GRIK2 interactions 9.805E-8 2.414E-6 1.583E-5 3.863E-5 3 26
17 int:SEMA4C SEMA4C interactions 1.235E-7 2.862E-6 1.876E-5 4.866E-5 3 28
18 int:LIN7A LIN7A interactions 3.175E-7 6.949E-6 4.555E-5 1.251E-4 3 38
19 int:MAPK12 MAPK12 interactions 3.717E-7 7.708E-6 5.052E-5 1.464E-4 3 40
20 int:GRIN2A GRIN2A interactions 4.640E-7 9.142E-6 5.992E-5 1.828E-4 3 43
21 int:CYYR1 CYYR1 interactions 8.038E-7 1.508E-5 9.886E-5 3.167E-4 2 4
22 int:DLG2 DLG2 interactions 8.794E-7 1.528E-5 1.002E-4 3.465E-4 3 53
23 int:CNKSR2 CNKSR2 interactions 9.309E-7 1.528E-5 1.002E-4 3.668E-4 3 54
24 int:LIN7C LIN7C interactions 9.309E-7 1.528E-5 1.002E-4 3.668E-4 3 54
25 int:ATP2B4 ATP2B4 interactions 1.349E-6 2.126E-5 1.394E-4 5.316E-4 3 61
26 int:DLG4 DLG4 interactions 1.894E-6 2.871E-5 1.882E-4 7.464E-4 4 274
27 int:DLG3 DLG3 interactions 3.558E-6 5.192E-5 3.403E-4 1.402E-3 3 84
28 int:ERBB4 ERBB4 interactions 3.820E-6 5.375E-5 3.524E-4 1.505E-3 3 86
29 int:GRID1 GRID1 interactions 4.818E-6 6.546E-5 4.291E-4 1.898E-3 2 9
30 int:NLGN1 NLGN1 interactions 6.022E-6 7.909E-5 5.184E-4 2.373E-3 2 10
31 int:GNG13 GNG13 interactions 7.359E-6 9.353E-5 6.131E-4 2.899E-3 2 11
32 int:DLG1 DLG1 interactions 8.023E-6 9.879E-5 6.475E-4 3.161E-3 3 110
33 int:GRIN1 GRIN1 interactions 8.470E-6 1.011E-4 6.629E-4 3.337E-3 3 112
34 int:NET1 NET1 interactions 8.829E-6 1.023E-4 6.706E-4 3.479E-3 2 12
35 int:ATP2B2 ATP2B2 interactions 1.150E-5 1.295E-4 8.487E-4 4.532E-3 3 124
36 int:MARCH2 MARCH2 interactions 1.217E-5 1.296E-4 8.494E-4 4.794E-3 2 14
37 int:FZD4 FZD4 interactions 1.217E-5 1.296E-4 8.494E-4 4.794E-3 2 14
38 int:SSTR3 SSTR3 interactions 1.404E-5 1.456E-4 9.541E-4 5.531E-3 2 15
39 int:GRID2 GRID2 interactions 1.604E-5 1.620E-4 1.062E-3 6.320E-3 2 16
40 int:SYNGAP1 SYNGAP1 interactions 1.764E-5 1.738E-4 1.139E-3 6.950E-3 3 143
41 int:FZD7 FZD7 interactions 1.818E-5 1.747E-4 1.145E-3 7.161E-3 2 17
42 int:ADRB1 ADRB1 interactions 2.044E-5 1.918E-4 1.257E-3 8.055E-3 2 18
43 int:DLGAP3 DLGAP3 interactions 2.284E-5 2.093E-4 1.372E-3 9.001E-3 2 19
44 int:ADGRB1 ADGRB1 interactions 2.804E-5 2.457E-4 1.611E-3 1.105E-2 2 21
45 int:DLGAP1 DLGAP1 interactions 2.807E-5 2.457E-4 1.611E-3 1.106E-2 3 167
46 int:DLGAP4 DLGAP4 interactions 3.084E-5 2.532E-4 1.659E-3 1.215E-2 2 22
47 int:MPP2 MPP2 interactions 3.084E-5 2.532E-4 1.659E-3 1.215E-2 2 22
48 int:TJAP1 TJAP1 interactions 3.084E-5 2.532E-4 1.659E-3 1.215E-2 2 22
49 int:NLGN2 NLGN2 interactions 3.377E-5 2.661E-4 1.744E-3 1.331E-2 2 23
50 int:APBA1 APBA1 interactions 3.377E-5 2.661E-4 1.744E-3 1.331E-2 2 23
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10q23 10q23 2.623E-3 1.760E-2 4.562E-2 1.836E-2 1 13
2 3p14.1 3p14.1 5.038E-3 1.760E-2 4.562E-2 3.527E-2 1 25
3 11q14.1 11q14.1 8.653E-3 1.760E-2 4.562E-2
6.057E-2
 1 43
4 Xq13.1 Xq13.1 1.006E-2 1.760E-2 4.562E-2
7.039E-2
 1 50
5 19q13.3 19q13.3 1.684E-2 2.062E-2
5.346E-2
1.179E-1
 1 84
6 3q29 3q29 1.784E-2 2.062E-2
5.346E-2
1.249E-1
 1 89
7 6q21 6q21 2.062E-2 2.062E-2
5.346E-2
1.443E-1
 1 103
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 94 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 2.472E-15 1.730E-14 4.487E-14 1.730E-14 7 152
2 904 Calcium voltage-gated channel subunits|Membrane associated guanylate kinases genenames.org 8.303E-14 2.906E-13 7.535E-13 5.812E-13 5 26
3 1224 WD repeat domain containing|Scribble complex genenames.org 1.538E-3 3.500E-3 9.076E-3 1.077E-2 1 4
4 694 Protein phosphatase 1 regulatory subunits genenames.org 2.000E-3 3.500E-3 9.076E-3 1.400E-2 2 181
5 1223 Crumbs complex genenames.org 3.458E-3 4.841E-3 1.255E-2 2.421E-2 1 9
6 775 Myb/SANT domain containing|Trinucleotide repeat containing genenames.org 9.581E-3 1.118E-2 2.898E-2
6.706E-2
 1 25
7 103 X-linked mental retardation|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 3.338E-2 3.338E-2
8.654E-2
2.336E-1
 1 88
Show 2 more annotations

13: Coexpression [Display Chart] 7 input genes in category / 504 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7144 Genes down-regulated in CD8A+ [GeneID=925] splenic dendritic cells: wildtype versus IFNB1 [GeneID=3456] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 2.139E-5 1.078E-2
7.330E-2
 1.078E-2 3 199

14: Coexpression Atlas [Display Chart] 7 input genes in category / 241 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 370 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-934:PITA hsa-miR-934:PITA TOP PITA 8.181E-8 3.027E-5 1.965E-4 3.027E-5 3 97
2 hsa-miR-1290:PITA hsa-miR-1290:PITA TOP PITA 3.991E-6 6.895E-4 4.476E-3 1.477E-3 3 353
3 hsa-miR-888:PITA hsa-miR-888:PITA TOP PITA 6.712E-6 6.895E-4 4.476E-3 2.483E-3 3 420
4 hsa-miR-579:PITA hsa-miR-579:PITA TOP PITA 7.454E-6 6.895E-4 4.476E-3 2.758E-3 3 435
5 hsa-miR-933:mirSVR highEffct hsa-miR-933:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.731E-5 2.761E-3 1.792E-2 1.380E-2 2 97
6 hsa-miR-1258:PITA hsa-miR-1258:PITA TOP PITA 6.708E-5 3.076E-3 1.997E-2 2.482E-2 2 130
7 hsa-miR-770-5p:PITA hsa-miR-770-5p:PITA TOP PITA 7.343E-5 3.076E-3 1.997E-2 2.717E-2 2 136
8 hsa-miR-626:PITA hsa-miR-626:PITA TOP PITA 7.670E-5 3.076E-3 1.997E-2 2.838E-2 2 139
9 ATGAAGG,MIR-205:MSigDB ATGAAGG,MIR-205:MSigDB MSigDB 8.347E-5 3.076E-3 1.997E-2 3.088E-2 2 145
10 hsa-miR-758:PITA hsa-miR-758:PITA TOP PITA 9.538E-5 3.076E-3 1.997E-2 3.529E-2 2 155
11 hsa-miR-628-3p:PITA hsa-miR-628-3p:PITA TOP PITA 1.016E-4 3.076E-3 1.997E-2 3.760E-2 2 160
12 hsa-miR-188-5p:TargetScan hsa-miR-188-5p TargetScan 1.055E-4 3.076E-3 1.997E-2 3.902E-2 2 163
13 hsa-miR-885-5p:PITA hsa-miR-885-5p:PITA TOP PITA 1.081E-4 3.076E-3 1.997E-2 3.999E-2 2 165
14 hsa-miR-219-2-3p:PITA hsa-miR-219-2-3p:PITA TOP PITA 1.433E-4 3.786E-3 2.458E-2
5.300E-2
 2 190
15 hsa-miR-593:PITA hsa-miR-593:PITA TOP PITA 1.716E-4 4.233E-3 2.748E-2
6.350E-2
 2 208
16 hsa-miR-1272:PITA hsa-miR-1272:PITA TOP PITA 1.919E-4 4.292E-3 2.786E-2
7.102E-2
 2 220
17 hsa-miR-24:PITA hsa-miR-24:PITA TOP PITA 1.972E-4 4.292E-3 2.786E-2
7.296E-2
 2 223
18 hsa-miR-1246:PITA hsa-miR-1246:PITA TOP PITA 2.152E-4 4.424E-3 2.872E-2
7.963E-2
 2 233
19 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 2.321E-4 4.441E-3 2.883E-2
8.588E-2
 2 242
20 hsa-miR-622:PITA hsa-miR-622:PITA TOP PITA 2.418E-4 4.441E-3 2.883E-2
8.945E-2
 2 247
21 hsa-miR-498:PITA hsa-miR-498:PITA TOP PITA 2.596E-4 4.441E-3 2.883E-2
9.606E-2
 2 256
22 hsa-miR-1301:PITA hsa-miR-1301:PITA TOP PITA 2.719E-4 4.441E-3 2.883E-2
1.006E-1
 2 262
23 CATTTCA,MIR-203:MSigDB CATTTCA,MIR-203:MSigDB MSigDB 2.760E-4 4.441E-3 2.883E-2
1.021E-1
 2 264
24 hsa-miR-302f:PITA hsa-miR-302f:PITA TOP PITA 2.951E-4 4.549E-3 2.953E-2
1.092E-1
 2 273
25 hsa-miR-605:PITA hsa-miR-605:PITA TOP PITA 3.328E-4 4.925E-3 3.198E-2
1.231E-1
 2 290
26 hsa-miR-557:PITA hsa-miR-557:PITA TOP PITA 3.655E-4 5.009E-3 3.252E-2
1.352E-1
 2 304
27 hsa-miR-507:PITA hsa-miR-507:PITA TOP PITA 3.655E-4 5.009E-3 3.252E-2
1.352E-1
 2 304
28 hsa-miR-513b:PITA hsa-miR-513b:PITA TOP PITA 4.124E-4 5.294E-3 3.437E-2
1.526E-1
 2 323
29 hsa-miR-580:PITA hsa-miR-580:PITA TOP PITA 4.149E-4 5.294E-3 3.437E-2
1.535E-1
 2 324
30 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 5.577E-4 6.516E-3 4.230E-2
2.063E-1
 2 376
31 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 5.577E-4 6.516E-3 4.230E-2
2.063E-1
 2 376
32 hsa-miR-583:PITA hsa-miR-583:PITA TOP PITA 5.636E-4 6.516E-3 4.230E-2
2.085E-1
 2 378
33 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 6.181E-4 6.726E-3 4.367E-2
2.287E-1
 2 396
34 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 6.181E-4 6.726E-3 4.367E-2
2.287E-1
 2 396
35 hsa-miR-205-5p:TargetScan hsa-miR-205-5p TargetScan 6.913E-4 7.308E-3 4.745E-2
2.558E-1
 2 419
36 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 8.034E-4 7.991E-3
5.188E-2
2.973E-1
 2 452
37 hsa-miR-369-3p:TargetScan hsa-miR-369-3p TargetScan 8.354E-4 7.991E-3
5.188E-2
3.091E-1
 2 461
38 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 9.013E-4 7.991E-3
5.188E-2
3.335E-1
 2 479
39 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 9.013E-4 7.991E-3
5.188E-2
3.335E-1
 2 479
40 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 9.162E-4 7.991E-3
5.188E-2
3.390E-1
 2 483
41 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 9.162E-4 7.991E-3
5.188E-2
3.390E-1
 2 483
42 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 9.162E-4 7.991E-3
5.188E-2
3.390E-1
 2 483
43 hsa-miR-520f-3p:TargetScan hsa-miR-520f-3p TargetScan 9.503E-4 7.991E-3
5.188E-2
3.516E-1
 2 492
44 hsa-miR-302c-3p.2:TargetScan hsa-miR-302c-3p.2 TargetScan 9.503E-4 7.991E-3
5.188E-2
3.516E-1
 2 492
45 AGCGCAG,MIR-191:MSigDB AGCGCAG,MIR-191:MSigDB MSigDB 1.162E-3 9.556E-3
6.204E-2
4.300E-1
 1 12
46 hsa-miR-1280:PITA hsa-miR-1280:PITA TOP PITA 1.646E-3 1.324E-2
8.596E-2
6.091E-1
 1 17
47 hsa-miR-933:PITA hsa-miR-933:PITA TOP PITA 1.743E-3 1.372E-2
8.908E-2
6.449E-1
 1 18
48 hsa-miR-563:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.613E-3 2.015E-2
1.308E-1
9.670E-1
 1 27
49 hsa-miR-380-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.710E-3 2.046E-2
1.329E-1
1.000E0
 1 28
50 hsa-miR-1287-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.966E-3 2.935E-2
1.905E-1
1.000E0
 1 41
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1799 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000448294 AC1L9LT0 Stitch 8.687E-11 1.563E-7 1.262E-6 1.563E-7 5 123
2 CID000166768 p-hydroxymandelonitrile Stitch 2.262E-8 2.034E-5 1.642E-4 4.068E-5 4 117
3 CID000000761 5'-GMP Na2 Stitch 1.536E-6 9.213E-4 7.437E-3 2.764E-3 4 335
4 2091 DN Etodolac [41340-25-4]; Down 200; 14uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.059E-5 7.995E-3
6.454E-2
 3.705E-2 3 194
5 6464 DN Nitrendipine [39562-70-4]; Down 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.222E-5 7.995E-3
6.454E-2
 3.997E-2 3 199
6 CID000062714 Li-H Stitch 6.245E-5 1.872E-2
1.512E-1
1.123E-1
 2 40
7 CID000013245 AC1MMLID Stitch 3.326E-4 2.222E-2
1.794E-1
5.984E-1
 2 92
8 CID009547984 PC 0 Stitch 6.129E-4 2.222E-2
1.794E-1
1.000E0
 1 2
9 CID000030332 aluminium phosphide Stitch 9.192E-4 2.222E-2
1.794E-1
1.000E0
 1 3
10 CID000155233 BH34 Stitch 9.192E-4 2.222E-2
1.794E-1
1.000E0
 1 3
11 CID006337812 6-selenoguanosine-5'-phosphate Stitch 9.192E-4 2.222E-2
1.794E-1
1.000E0
 1 3
12 CID000065132 alizarin complexone Stitch 9.192E-4 2.222E-2
1.794E-1
1.000E0
 1 3
13 CID000026129 sodium ferrocyanide Stitch 1.225E-3 2.222E-2
1.794E-1
1.000E0
 1 4
14 5530 DN Parthenolide [20554-84-1]; Down 200; 16.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.306E-3 2.222E-2
1.794E-1
1.000E0
 2 183
15 2344 UP Salbutamol [18559-94-9]; Up 200; 16.8uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.363E-3 2.222E-2
1.794E-1
1.000E0
 2 187
16 887 DN celastrol; Down 200; 2.5uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.377E-3 2.222E-2
1.794E-1
1.000E0
 2 188
17 2896 DN Mometasone furoate [83919-23-7]; Down 200; 7.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.377E-3 2.222E-2
1.794E-1
1.000E0
 2 188
18 913 DN forskolin; Down 200; 50uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.392E-3 2.222E-2
1.794E-1
1.000E0
 2 189
19 5248 DN Phenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.392E-3 2.222E-2
1.794E-1
1.000E0
 2 189
20 7528 DN pioglitazone HCl; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.406E-3 2.222E-2
1.794E-1
1.000E0
 2 190
21 3379 DN Luteolin [491-70-3]; Down 200; 14uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.406E-3 2.222E-2
1.794E-1
1.000E0
 2 190
22 3348 DN Azacytidine-5 [320-67-2]; Down 200; 16.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.406E-3 2.222E-2
1.794E-1
1.000E0
 2 190
23 1041 DN haloperidol; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.421E-3 2.222E-2
1.794E-1
1.000E0
 2 191
24 2499 DN Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.421E-3 2.222E-2
1.794E-1
1.000E0
 2 191
25 2846 UP Trimethadione [127-48-0]; Up 200; 28uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.436E-3 2.222E-2
1.794E-1
1.000E0
 2 192
26 1647 DN 2-propylpentanoic acid; Down 200; 50uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.222E-2
1.794E-1
1.000E0
 2 192
27 5509 DN Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.222E-2
1.794E-1
1.000E0
 2 192
28 2271 DN Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.222E-2
1.794E-1
1.000E0
 2 192
29 446 DN 15d-PGJ2; Down 200; 10uM; PC3; HG-U133A Broad Institute CMAP Down 1.436E-3 2.222E-2
1.794E-1
1.000E0
 2 192
30 3318 DN Hexetidine [141-94-6]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.436E-3 2.222E-2
1.794E-1
1.000E0
 2 192
31 2828 DN Omeprazole [73590-58-6]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.222E-2
1.794E-1
1.000E0
 2 193
32 901 DN 5114445; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.451E-3 2.222E-2
1.794E-1
1.000E0
 2 193
33 5101 DN Prednisolone [50-24-8]; Down 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.222E-2
1.794E-1
1.000E0
 2 193
34 2294 DN Dilazep dihydrochloride [20153-98-4]; Down 200; 6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.451E-3 2.222E-2
1.794E-1
1.000E0
 2 193
35 5674 DN Bepridil hydrochloride [74764-40-2]; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.465E-3 2.222E-2
1.794E-1
1.000E0
 2 194
36 5328 UP Betamethasone [378-44-9]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.465E-3 2.222E-2
1.794E-1
1.000E0
 2 194
37 7545 DN semustine; Down 200; 100uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.465E-3 2.222E-2
1.794E-1
1.000E0
 2 194
38 5440 DN Imipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.465E-3 2.222E-2
1.794E-1
1.000E0
 2 194
39 5430 DN Procaine hydrochloride [51-05-8]; Down 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
40 3512 DN Piribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
41 3504 DN Asiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
42 1520 DN Azacyclonol [115-46-8]; Down 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
43 564 UP 15d-PGJ2; Up 200; 10uM; SKMEL5; HG-U133A Broad Institute CMAP Up 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
44 5448 DN Iopanoic acid [96-83-3]; Down 200; 7uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
45 7225 DN Oxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
46 910 DN trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
47 7060 UP SC 19220; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
48 6583 UP STOCK1N-35874; Up 200; 14uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.480E-3 2.222E-2
1.794E-1
1.000E0
 2 195
49 6171 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.495E-3 2.222E-2
1.794E-1
1.000E0
 2 196
50 4776 DN Norcyclobenzaprine [303-50-4]; Down 200; 15.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.495E-3 2.222E-2
1.794E-1
1.000E0
 2 196
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 85 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:CN069586 X-Linked mental retardation 90 Clinical Variations 4.320E-4 1.836E-2
9.225E-2
 3.672E-2 1 1
2 C2674949 Chromosome 3q29 Deletion Syndrome DisGeNET BeFree 4.320E-4 1.836E-2
9.225E-2
 3.672E-2 1 1
3 20081125:Fung Parkinson's disease GWAS 8.638E-4 1.836E-2
9.225E-2
7.342E-2
 1 2
4 OMIN:102530 GLOBOZOOSPERMIA OMIM 8.638E-4 1.836E-2
9.225E-2
7.342E-2
 1 2
5 C0266316 Congenital hydronephrosis DisGeNET Curated 1.727E-3 2.936E-2
1.475E-1
1.468E-1
 1 4
6 C1845862 Creatine deficiency, X-linked DisGeNET Curated 2.589E-3 3.668E-2
1.843E-1
2.201E-1
 1 6
7 C0014394 Enuresis DisGeNET Curated 3.020E-3 3.668E-2
1.843E-1
2.567E-1
 1 7
8 C1656427 early onset schizophrenia DisGeNET Curated 3.882E-3 4.125E-2
2.073E-1
3.300E-1
 1 9
9 C0809983 Schizophrenia and related disorders DisGeNET Curated 5.603E-3 4.445E-2
2.234E-1
4.763E-1
 1 13
10 OMIN:266600 INFLAMMATORY BOWEL DISEASE 1; IBD1 OMIM 6.033E-3 4.445E-2
2.234E-1
5.128E-1
 1 14
11 C2931133 Pediatric Crohn's disease DisGeNET BeFree 6.892E-3 4.445E-2
2.234E-1
5.858E-1
 1 16
12 C1301363 Blastic plasmacytoid dendritic cell neoplasm DisGeNET BeFree 6.892E-3 4.445E-2
2.234E-1
5.858E-1
 1 16
13 C1698581 Rokitansky Kuster Hauser syndrome DisGeNET Curated 7.322E-3 4.445E-2
2.234E-1
6.223E-1
 1 17
14 C0272002 alpha^0^ Thalassemia DisGeNET BeFree 7.322E-3 4.445E-2
2.234E-1
6.223E-1
 1 17
15 C0346255 Oncocytoma, renal DisGeNET Curated 8.609E-3 4.801E-2
2.413E-1
7.318E-1
 1 20
16 C2931498 Mental Retardation, X-Linked 1 DisGeNET Curated 9.038E-3 4.801E-2
2.413E-1
7.682E-1
 1 21
17 C0233514 Abnormal behavior DisGeNET Curated 9.858E-3 4.929E-2
2.477E-1
8.379E-1
 2 365
Show 12 more annotations