Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc406_8, positive side

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Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 8 input genes in category / 39 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031419 cobalamin binding 5.781E-6 1.721E-4 7.322E-4 2.255E-4 2 9
2 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor 8.828E-6 1.721E-4 7.322E-4 3.443E-4 2 11
3 GO:0016722 oxidoreductase activity, oxidizing metal ions 2.452E-5 3.188E-4 1.356E-3 9.563E-4 2 18
4 GO:0016866 intramolecular transferase activity 5.615E-5 5.474E-4 2.328E-3 2.190E-3 2 27
5 GO:0047138 aquacobalamin reductase activity 4.287E-4 1.858E-3 7.902E-3 1.672E-2 1 1
6 GO:0050444 aquacobalamin reductase (NADPH) activity 4.287E-4 1.858E-3 7.902E-3 1.672E-2 1 1
7 GO:0033787 cyanocobalamin reductase (cyanide-eliminating) activity 4.287E-4 1.858E-3 7.902E-3 1.672E-2 1 1
8 GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity 4.287E-4 1.858E-3 7.902E-3 1.672E-2 1 1
9 GO:0004494 methylmalonyl-CoA mutase activity 4.287E-4 1.858E-3 7.902E-3 1.672E-2 1 1
10 GO:0019842 vitamin binding 6.320E-4 2.465E-3 1.048E-2 2.465E-2 2 90
11 GO:0030586 [methionine synthase] reductase activity 8.572E-4 3.039E-3 1.293E-2 3.343E-2 1 2
12 GO:0015234 thiamine transmembrane transporter activity 1.286E-3 4.178E-3 1.777E-2
5.014E-2
 1 3
13 GO:0046906 tetrapyrrole binding 1.519E-3 4.557E-3 1.938E-2
5.925E-2
 2 140
14 GO:0004614 phosphoglucomutase activity 1.714E-3 4.774E-3 2.031E-2
6.684E-2
 1 4
15 GO:0003958 NADPH-hemoprotein reductase activity 2.142E-3 5.432E-3 2.310E-2
8.353E-2
 1 5
16 GO:0016853 isomerase activity 2.228E-3 5.432E-3 2.310E-2
8.691E-2
 2 170
17 GO:0090482 vitamin transmembrane transporter activity 2.998E-3 6.495E-3 2.763E-2
1.169E-1
 1 7
18 GO:1901474 azole transmembrane transporter activity 2.998E-3 6.495E-3 2.763E-2
1.169E-1
 1 7
19 GO:0008517 folic acid transmembrane transporter activity 3.425E-3 7.030E-3 2.990E-2
1.336E-1
 1 8
20 GO:0016868 intramolecular transferase activity, phosphotransferases 4.707E-3 8.741E-3 3.718E-2
1.836E-1
 1 11
21 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4.707E-3 8.741E-3 3.718E-2
1.836E-1
 1 11
22 GO:0071949 FAD binding 6.414E-3 1.042E-2 4.433E-2
2.501E-1
 1 15
23 GO:0070402 NADPH binding 6.414E-3 1.042E-2 4.433E-2
2.501E-1
 1 15
24 GO:0010181 FMN binding 6.414E-3 1.042E-2 4.433E-2
2.501E-1
 1 15
25 GO:0051184 cofactor transmembrane transporter activity 9.394E-3 1.466E-2
6.234E-2
3.664E-1
 1 22
26 GO:0015238 drug transmembrane transporter activity 1.067E-2 1.600E-2
6.807E-2
4.161E-1
 1 25
27 GO:1901682 sulfur compound transmembrane transporter activity 1.237E-2 1.786E-2
7.598E-2
4.823E-1
 1 29
28 GO:0050661 NADP binding 2.040E-2 2.841E-2
1.208E-1
7.955E-1
 1 48
29 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2.670E-2 3.590E-2
1.527E-1
1.000E0
 1 63
30 GO:0072341 modified amino acid binding 3.129E-2 4.042E-2
1.719E-1
1.000E0
 1 74
31 GO:0050660 flavin adenine dinucleotide binding 3.213E-2 4.042E-2
1.719E-1
1.000E0
 1 76
Show 26 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 141 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0009235 cobalamin metabolic process 2.621E-17 3.696E-15 2.043E-14 3.696E-15 6 21
2 GO:0006767 water-soluble vitamin metabolic process 3.286E-16 2.317E-14 1.281E-13 4.633E-14 7 88
3 GO:0006766 vitamin metabolic process 6.779E-15 3.186E-13 1.762E-12 9.559E-13 7 134
4 GO:0033013 tetrapyrrole metabolic process 4.800E-14 1.692E-12 9.355E-12 6.768E-12 6 67
5 GO:0009236 cobalamin biosynthetic process 5.203E-11 1.467E-9 8.113E-9 7.336E-9 3 3
6 GO:0042364 water-soluble vitamin biosynthetic process 4.365E-9 1.026E-7 5.672E-7 6.155E-7 3 9
7 GO:0009110 vitamin biosynthetic process 1.191E-7 2.400E-6 1.327E-5 1.680E-5 3 25
8 GO:0033014 tetrapyrrole biosynthetic process 2.566E-7 4.522E-6 2.500E-5 3.618E-5 3 32
9 GO:0019626 short-chain fatty acid catabolic process 3.387E-6 5.307E-5 2.934E-4 4.776E-4 2 7
10 GO:0044282 small molecule catabolic process 1.008E-5 1.421E-4 7.856E-4 1.421E-3 4 370
11 GO:0046459 short-chain fatty acid metabolic process 1.691E-5 1.987E-4 1.099E-3 2.384E-3 2 15
12 GO:0050667 homocysteine metabolic process 1.691E-5 1.987E-4 1.099E-3 2.384E-3 2 15
13 GO:0016054 organic acid catabolic process 1.021E-4 1.028E-3 5.684E-3 1.439E-2 3 232
14 GO:0046395 carboxylic acid catabolic process 1.021E-4 1.028E-3 5.684E-3 1.439E-2 3 232
15 GO:0000096 sulfur amino acid metabolic process 1.445E-4 1.359E-3 7.513E-3 2.038E-2 2 43
16 GO:1904041 regulation of cystathionine beta-synthase activity 4.296E-4 3.563E-3 1.970E-2
6.057E-2
 1 1
17 GO:1904042 negative regulation of cystathionine beta-synthase activity 4.296E-4 3.563E-3 1.970E-2
6.057E-2
 1 1
18 GO:0006790 sulfur compound metabolic process 5.233E-4 4.099E-3 2.267E-2
7.378E-2
 3 404
19 GO:0009062 fatty acid catabolic process 7.216E-4 5.355E-3 2.961E-2
1.017E-1
 2 96
20 GO:0043418 homocysteine catabolic process 8.590E-4 6.056E-3 3.349E-2
1.211E-1
 1 2
21 GO:0072329 monocarboxylic acid catabolic process 1.106E-3 7.423E-3 4.105E-2
1.559E-1
 2 119
22 GO:0071934 thiamine transmembrane transport 1.288E-3 8.256E-3 4.565E-2
1.816E-1
 1 3
23 GO:0015888 thiamine transport 1.717E-3 1.053E-2
5.821E-2
2.421E-1
 1 4
24 GO:0042723 thiamine-containing compound metabolic process 2.575E-3 1.452E-2
8.031E-2
3.631E-1
 1 6
25 GO:0033353 S-adenosylmethionine cycle 2.575E-3 1.452E-2
8.031E-2
3.631E-1
 1 6
26 GO:0019388 galactose catabolic process 3.004E-3 1.577E-2
8.719E-2
4.235E-1
 1 7
27 GO:0044242 cellular lipid catabolic process 3.019E-3 1.577E-2
8.719E-2
4.257E-1
 2 198
28 GO:0035461 vitamin transmembrane transport 3.432E-3 1.728E-2
9.557E-2
4.839E-1
 1 8
29 GO:0015884 folic acid transport 3.860E-3 1.814E-2
1.003E-1
5.443E-1
 1 9
30 GO:0000098 sulfur amino acid catabolic process 3.860E-3 1.814E-2
1.003E-1
5.443E-1
 1 9
31 GO:1901605 alpha-amino acid metabolic process 4.654E-3 2.051E-2
1.134E-1
6.562E-1
 2 247
32 GO:0006575 cellular modified amino acid metabolic process 4.654E-3 2.051E-2
1.134E-1
6.562E-1
 2 247
33 GO:0006012 galactose metabolic process 5.572E-3 2.245E-2
1.241E-1
7.856E-1
 1 13
34 GO:0072531 pyrimidine-containing compound transmembrane transport 5.572E-3 2.245E-2
1.241E-1
7.856E-1
 1 13
35 GO:0046498 S-adenosylhomocysteine metabolic process 5.572E-3 2.245E-2
1.241E-1
7.856E-1
 1 13
36 GO:0009086 methionine biosynthetic process 6.427E-3 2.517E-2
1.392E-1
9.062E-1
 1 15
37 GO:0016042 lipid catabolic process 6.925E-3 2.639E-2
1.459E-1
9.764E-1
 2 303
38 GO:0046655 folic acid metabolic process 7.708E-3 2.717E-2
1.502E-1
1.000E0
 1 18
39 GO:0046500 S-adenosylmethionine metabolic process 7.708E-3 2.717E-2
1.502E-1
1.000E0
 1 18
40 GO:0006555 methionine metabolic process 7.708E-3 2.717E-2
1.502E-1
1.000E0
 1 18
41 GO:0042219 cellular modified amino acid catabolic process 8.134E-3 2.791E-2
1.543E-1
1.000E0
 1 19
42 GO:0006732 coenzyme metabolic process 8.312E-3 2.791E-2
1.543E-1
1.000E0
 2 333
43 GO:0000097 sulfur amino acid biosynthetic process 8.987E-3 2.947E-2
1.630E-1
1.000E0
 1 21
44 GO:0046128 purine ribonucleoside metabolic process 9.712E-3 3.092E-2
1.710E-1
1.000E0
 2 361
45 GO:0042278 purine nucleoside metabolic process 9.868E-3 3.092E-2
1.710E-1
1.000E0
 2 364
46 GO:0009067 aspartate family amino acid biosynthetic process 1.027E-2 3.147E-2
1.740E-1
1.000E0
 1 24
47 GO:0006631 fatty acid metabolic process 1.066E-2 3.165E-2
1.750E-1
1.000E0
 2 379
48 GO:0009119 ribonucleoside metabolic process 1.132E-2 3.165E-2
1.750E-1
1.000E0
 2 391
49 GO:0045117 azole transport 1.154E-2 3.165E-2
1.750E-1
1.000E0
 1 27
50 GO:0051181 cofactor transport 1.154E-2 3.165E-2
1.750E-1
1.000E0
 1 27
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 3 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005759 mitochondrial matrix 5.671E-4 1.701E-3 3.119E-3 1.701E-3 3 425

4: Human Phenotype [Display Chart] 7 input genes in category / 233 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003210 Decreased methylmalonyl-CoA mutase activity 1.713E-12 3.693E-10 2.227E-9 3.992E-10 4 4
2 HP:0012120 Methylmalonic aciduria 3.271E-12 3.693E-10 2.227E-9 7.620E-10 5 15
3 HP:0002912 Methylmalonic acidemia 4.755E-12 3.693E-10 2.227E-9 1.108E-9 5 16
4 HP:0003145 Decreased adenosylcobalamin 2.567E-11 1.496E-9 9.019E-9 5.982E-9 4 6
5 HP:0000816 Abnormality of Krebs cycle metabolism 5.988E-11 2.790E-9 1.683E-8 1.395E-8 4 7
6 HP:0004341 Abnormality of vitamin B12 metabolism 7.103E-10 2.758E-8 1.663E-7 1.655E-7 5 40
7 HP:0040126 Abnormal vitamin B12 level 8.447E-10 2.812E-8 1.695E-7 1.968E-7 4 12
8 HP:0003112 Abnormality of serum amino acid level 1.038E-9 3.023E-8 1.823E-7 2.418E-7 5 43
9 HP:0003215 Dicarboxylic aciduria 2.279E-9 5.900E-8 3.558E-7 5.310E-7 5 50
10 HP:0010995 Abnormality of dicarboxylic acid metabolism 3.735E-9 8.703E-8 5.248E-7 8.703E-7 5 55
11 HP:0001254 Lethargy 1.706E-8 3.614E-7 2.179E-6 3.975E-6 6 176
12 HP:0004340 Abnormality of vitamin B metabolism 3.086E-8 5.992E-7 3.614E-6 7.191E-6 5 83
13 HP:0003355 Aminoaciduria 8.362E-8 1.499E-6 9.038E-6 1.948E-5 6 229
14 HP:0001992 Organic aciduria 1.174E-7 1.954E-6 1.179E-5 2.736E-5 5 108
15 HP:0012072 Aciduria 1.452E-7 2.256E-6 1.360E-5 3.384E-5 6 251
16 HP:0004337 Abnormality of amino acid metabolism 3.115E-7 4.536E-6 2.735E-5 7.257E-5 6 285
17 HP:0004354 Abnormality of carboxylic acid metabolism 3.457E-7 4.738E-6 2.857E-5 8.055E-5 6 290
18 HP:0002154 Hyperglycinemia 5.726E-7 7.412E-6 4.470E-5 1.334E-4 3 13
19 HP:0001972 Macrocytic anemia 2.233E-6 2.739E-5 1.652E-4 5.204E-4 4 77
20 HP:0100508 Abnormality of vitamin metabolism 2.457E-6 2.863E-5 1.726E-4 5.725E-4 5 198
21 HP:0001889 Megaloblastic anemia 3.523E-6 3.909E-5 2.357E-4 8.209E-4 3 23
22 HP:0010895 Abnormality of glycine metabolism 4.024E-6 4.076E-5 2.458E-4 9.376E-4 3 24
23 HP:0010894 Abnormality of serine family amino acid metabolism 4.024E-6 4.076E-5 2.458E-4 9.376E-4 3 24
24 HP:0003658 Hypomethioninemia 1.136E-5 1.059E-4 6.385E-4 2.647E-3 2 4
25 HP:0001980 Megaloblastic bone marrow 1.136E-5 1.059E-4 6.385E-4 2.647E-3 2 4
26 HP:0003524 Decreased methionine synthase activity 2.836E-5 2.447E-4 1.476E-3 6.608E-3 2 6
27 HP:0003223 Decreased methylcobalamin 2.836E-5 2.447E-4 1.476E-3 6.608E-3 2 6
28 HP:0002160 Hyperhomocystinemia 3.968E-5 3.302E-4 1.991E-3 9.245E-3 2 7
29 HP:0002039 Anorexia 6.192E-5 4.975E-4 3.000E-3 1.443E-2 4 177
30 HP:0010972 Anemia of inadequate production 8.356E-5 6.490E-4 3.914E-3 1.947E-2 4 191
31 HP:0012145 Abnormality of multiple cell lineages in the bone marrow 8.705E-5 6.543E-4 3.946E-3 2.028E-2 4 193
32 HP:0001942 Metabolic acidosis 9.249E-5 6.734E-4 4.061E-3 2.155E-2 4 196
33 HP:0001946 Ketosis 9.686E-5 6.839E-4 4.124E-3 2.257E-2 3 68
34 HP:0001987 Hyperammonemia 1.299E-4 8.904E-4 5.369E-3 3.027E-2 3 75
35 HP:0001941 Acidosis 1.812E-4 1.207E-3 7.276E-3 4.223E-2 5 475
36 HP:0010901 Abnormality of methionine metabolism 1.973E-4 1.277E-3 7.699E-3 4.596E-2 2 15
37 HP:0010919 Abnormality of homocysteine metabolism 2.253E-4 1.381E-3 8.330E-3
5.249E-2
 2 16
38 HP:0002156 Homocystinuria 2.253E-4 1.381E-3 8.330E-3
5.249E-2
 2 16
39 HP:0003107 Abnormality of cholesterol metabolism 2.548E-4 1.522E-3 9.179E-3
5.936E-2
 4 254
40 HP:0010899 Abnormality of aspartate family amino acid metabolism 5.596E-4 3.260E-3 1.966E-2
1.304E-1
 2 25
41 HP:0001875 Neutropenia 6.531E-4 3.710E-3 2.237E-2
1.522E-1
 4 324
42 HP:0011991 Abnormal neutrophil count 6.688E-4 3.710E-3 2.237E-2
1.558E-1
 4 326
43 HP:0002919 Ketonuria 7.552E-4 4.092E-3 2.468E-2
1.760E-1
 2 29
44 HP:0004339 Abnormality of sulfur amino acid metabolism 1.102E-3 5.836E-3 3.519E-2
2.568E-1
 2 35
45 HP:0001874 Abnormality of neutrophils 1.340E-3 6.932E-3 4.180E-2
3.123E-1
 4 391
46 HP:0002903 Aminoaciduria 1.369E-3 6.932E-3 4.180E-2
3.189E-1
 2 39
47 HP:0001944 Dehydration 1.480E-3 7.219E-3 4.353E-2
3.449E-1
 3 171
48 HP:0004860 Thiamine-responsive megaloblastic anemia 1.487E-3 7.219E-3 4.353E-2
3.465E-1
 1 1
49 HP:0003119 Abnormality of lipid metabolism 2.151E-3 1.023E-2
6.167E-2
5.011E-1
 4 443
50 HP:0002157 Azotemia 2.645E-3 1.233E-2
7.434E-2
6.163E-1
 3 209
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 212 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0012335 increased circulating homocysteine level 1.452E-5 1.795E-3 1.066E-2 3.078E-3 2 13
2 MP:0006076 abnormal circulating homocysteine level 1.694E-5 1.795E-3 1.066E-2 3.590E-3 2 14
3 MP:0005311 abnormal circulating amino acid level 2.064E-4 1.458E-2
8.658E-2
 4.375E-2 3 289
4 MP:0005332 abnormal amino acid level 3.891E-4 1.462E-2
8.681E-2
8.249E-2
 3 358
5 MP:0030645 decreased circulating methionine level 4.829E-4 1.462E-2
8.681E-2
1.024E-1
 1 1
6 MP:0030614 methylmalonic aciduria 4.829E-4 1.462E-2
8.681E-2
1.024E-1
 1 1
7 MP:0030642 decreased methionine level 4.829E-4 1.462E-2
8.681E-2
1.024E-1
 1 1
8 MP:0030655 increased circulating glycine level 1.448E-3 3.837E-2
2.278E-1
3.070E-1
 1 3
9 MP:0012117 decreased trophectoderm cell proliferation 1.930E-3 4.547E-2
2.699E-1
4.092E-1
 1 4
10 MP:0030654 abnormal circulating glycine level 2.412E-3 4.720E-2
2.802E-1
5.114E-1
 1 5
11 MP:0030613 dicarboxylic aciduria 2.894E-3 4.720E-2
2.802E-1
6.136E-1
 1 6
12 MP:0011637 abnormal mitochondrial matrix morphology 2.894E-3 4.720E-2
2.802E-1
6.136E-1
 1 6
13 MP:0030658 increased glycine level 2.894E-3 4.720E-2
2.802E-1
6.136E-1
 1 6
14 MP:0030612 organic aciduria 3.376E-3 4.772E-2
2.832E-1
7.157E-1
 1 7
15 MP:0012115 abnormal trophectoderm cell proliferation 3.376E-3 4.772E-2
2.832E-1
7.157E-1
 1 7
16 MP:0030657 abnormal glycine level 3.858E-3 4.811E-2
2.856E-1
8.178E-1
 1 8
17 MP:0003030 acidemia 3.858E-3 4.811E-2
2.856E-1
8.178E-1
 1 8
Show 12 more annotations

6: Domain [Display Chart] 8 input genes in category / 58 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00544 METMALONYL COA MUTASE PROSITE 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
2 IPR006099 MeMalonylCoA mutase a/b cat InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
3 1.20.1200.10 - Gene3D 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
4 IPR029499 PduO-typ InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
5 IPR006098 MMCoA mutase a cat InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
6 PF01642 MM CoA mutase Pfam 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
7 IPR006159 Acid CoA mut C InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
8 PF16690 MMACHC Pfam 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
9 PD007457 AdoCbl syn CblAdoTrfase PduO N ProDom 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
10 IPR016030 AdoCbl synth CblAdoTrfase-like InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
11 IPR014348 Cbl-dep enz cat-sub InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
12 IPR032037 MMACHC InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
13 3.20.20.240 - Gene3D 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
14 PF01923 Cob adeno trans Pfam 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
15 IPR028338 ThTr-1 InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
16 IPR016176 Cbl-dep enz cat InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
17 IPR005129 GTPase ArgK InterPro 4.270E-4 1.457E-3 6.769E-3 2.477E-2 1 1
18 PS51332 B12 BINDING PROSITE 8.539E-4 2.153E-3 1.000E-2 4.952E-2 1 2
19 PF10229 MMADHC Pfam 8.539E-4 2.153E-3 1.000E-2 4.952E-2 1 2
20 3.40.50.280 - Gene3D 8.539E-4 2.153E-3 1.000E-2 4.952E-2 1 2
21 IPR019362 MMADHC InterPro 8.539E-4 2.153E-3 1.000E-2 4.952E-2 1 2
22 PF02310 B12-binding Pfam 8.539E-4 2.153E-3 1.000E-2 4.952E-2 1 2
23 IPR006158 Cobalamin-bd InterPro 8.539E-4 2.153E-3 1.000E-2 4.952E-2 1 2
24 IPR005846 A-D-PHexomutase a/b/a-III InterPro 1.707E-3 3.173E-3 1.474E-2
9.901E-2
 1 4
25 IPR002666 Folate carrier InterPro 1.707E-3 3.173E-3 1.474E-2
9.901E-2
 1 4
26 IPR016066 A-D-PHexomutase CS InterPro 1.707E-3 3.173E-3 1.474E-2
9.901E-2
 1 4
27 PF01770 Folate carrier Pfam 1.707E-3 3.173E-3 1.474E-2
9.901E-2
 1 4
28 PF02880 PGM PMM III Pfam 1.707E-3 3.173E-3 1.474E-2
9.901E-2
 1 4
29 PF00408 PGM PMM IV Pfam 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
30 IPR005841 Alpha-D-phosphohexomutase SF InterPro 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
31 PF02878 PGM PMM I Pfam 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
32 IPR005844 A-D-PHexomutase a/b/a-I InterPro 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
33 PS00710 PGM PMM PROSITE 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
34 3.30.310.50 - Gene3D 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
35 PF02879 PGM PMM II Pfam 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
36 IPR005845 A-D-PHexomutase a/b/a-II InterPro 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
37 3.40.120.10 - Gene3D 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
38 IPR005843 A-D-PHexomutase C InterPro 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
39 IPR016055 A-D-PHexomutase a/b/a-I/II/III InterPro 2.133E-3 3.173E-3 1.474E-2
1.237E-1
 1 5
40 PF00667 FAD binding 1 Pfam 2.560E-3 3.453E-3 1.604E-2
1.485E-1
 1 6
41 1.20.990.10 - Gene3D 2.560E-3 3.453E-3 1.604E-2
1.485E-1
 1 6
42 IPR003097 FAD-binding 1 InterPro 2.560E-3 3.453E-3 1.604E-2
1.485E-1
 1 6
43 IPR023173 NADPH Cyt P450 Rdtase dom3 InterPro 2.560E-3 3.453E-3 1.604E-2
1.485E-1
 1 6
44 PS50902 FLAVODOXIN LIKE PROSITE 3.412E-3 4.210E-3 1.956E-2
1.979E-1
 1 8
45 IPR008254 Flavodoxin/NO synth InterPro 3.412E-3 4.210E-3 1.956E-2
1.979E-1
 1 8
46 IPR001094 Flavdoxin-like InterPro 3.412E-3 4.210E-3 1.956E-2
1.979E-1
 1 8
47 PF00258 Flavodoxin 1 Pfam 3.412E-3 4.210E-3 1.956E-2
1.979E-1
 1 8
48 IPR001709 Flavoprot Pyr Nucl cyt Rdtase InterPro 4.263E-3 4.945E-3 2.298E-2
2.472E-1
 1 10
49 3.40.50.360 - Gene3D 4.263E-3 4.945E-3 2.298E-2
2.472E-1
 1 10
50 IPR029039 Flavoprotein-like dom InterPro 4.263E-3 4.945E-3 2.298E-2
2.472E-1
 1 10
Show 45 more annotations

7: Pathway [Display Chart] 8 input genes in category / 72 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270152 Cobalamin (Cbl, vitamin B12) transport and metabolism BioSystems: REACTOME 4.035E-16 2.905E-14 1.412E-13 2.905E-14 6 22
2 1268960 Defects in cobalamin (B12) metabolism BioSystems: REACTOME 1.778E-14 6.402E-13 3.112E-12 1.280E-12 5 12
3 1270145 Metabolism of water-soluble vitamins and cofactors BioSystems: REACTOME 6.889E-14 1.653E-12 8.036E-12 4.960E-12 7 125
4 1268959 Defects in vitamin and cofactor metabolism BioSystems: REACTOME 1.921E-13 3.459E-12 1.681E-11 1.383E-11 5 18
5 1270144 Metabolism of vitamins and cofactors BioSystems: REACTOME 8.242E-13 1.187E-11 5.769E-11 5.935E-11 7 177
6 1268939 Diseases of metabolism BioSystems: REACTOME 2.725E-11 3.270E-10 1.589E-9 1.962E-9 5 45
7 1268972 Defective MUT causes methylmalonic aciduria mut type BioSystems: REACTOME 3.613E-7 2.891E-6 1.405E-5 2.601E-5 2 2
8 1268971 Defective MMAA causes methylmalonic aciduria type cblA BioSystems: REACTOME 3.613E-7 2.891E-6 1.405E-5 2.601E-5 2 2
9 1268967 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD BioSystems: REACTOME 3.613E-7 2.891E-6 1.405E-5 2.601E-5 2 2
10 1270025 Propionyl-CoA catabolism BioSystems: REACTOME 3.610E-6 2.599E-5 1.263E-4 2.599E-4 2 5
11 1270015 Mitochondrial Fatty Acid Beta-Oxidation BioSystems: REACTOME 8.293E-5 5.428E-4 2.638E-3 5.971E-3 2 22
12 199556 Vitamin digestion and absorption BioSystems: KEGG 9.902E-5 5.941E-4 2.888E-3 7.129E-3 2 24
13 SMP00200 Methylmalonic Aciduria SMPDB 6.426E-4 3.084E-3 1.499E-2 4.627E-2 1 1
14 SMP00201 Methylmalonic Aciduria Due to Cobalamin-Related Disorders SMPDB 6.426E-4 3.084E-3 1.499E-2 4.627E-2 1 1
15 1268966 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC BioSystems: REACTOME 6.426E-4 3.084E-3 1.499E-2 4.627E-2 1 1
16 P02777 Succinate to proprionate conversion PantherDB 1.285E-3 5.441E-3 2.645E-2
9.250E-2
 1 2
17 PW:0000399 remethylation of homocysteine metabolism - cobalamin dependent Pathway Ontology 1.285E-3 5.441E-3 2.645E-2
9.250E-2
 1 2
18 1268968 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE BioSystems: REACTOME 1.927E-3 7.301E-3 3.549E-2
1.387E-1
 1 3
19 1268969 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG BioSystems: REACTOME 1.927E-3 7.301E-3 3.549E-2
1.387E-1
 1 3
20 P02755 Methylmalonyl pathway PantherDB 2.568E-3 8.805E-3 4.280E-2
1.849E-1
 1 4
21 1239574 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA BioSystems: KEGG 2.568E-3 8.805E-3 4.280E-2
1.849E-1
 1 4
22 1270147 Vitamin B1 (thiamin) metabolism BioSystems: REACTOME 3.209E-3 1.005E-2 4.883E-2
2.311E-1
 1 5
23 1269969 Galactose catabolism BioSystems: REACTOME 3.209E-3 1.005E-2 4.883E-2
2.311E-1
 1 5
24 PW:0000186 streptomycin biosynthetic Pathway Ontology 3.850E-3 1.155E-2
5.614E-2
2.772E-1
 1 6
25 664436 Nucleotide sugar biosynthesis, glucose => UDP-glucose BioSystems: KEGG 4.490E-3 1.243E-2
6.044E-2
3.233E-1
 1 7
26 SMP00010 Nucleotide Sugars Metabolism SMPDB 4.490E-3 1.243E-2
6.044E-2
3.233E-1
 1 7
27 PW:0000042 galactose metabolic Pathway Ontology 5.770E-3 1.484E-2
7.212E-2
4.155E-1
 1 9
28 M3061 Feeder Pathways for Glycolysis MSigDB C2 BIOCARTA (v6.0) 5.770E-3 1.484E-2
7.212E-2
4.155E-1
 1 9
29 SMP00016 Propanoate Metabolism SMPDB 7.687E-3 1.873E-2
9.105E-2
5.535E-1
 1 12
30 SMP00040 Glycolysis SMPDB 8.325E-3 1.873E-2
9.105E-2
5.994E-1
 1 13
31 MAP00530 Aminosugars metabolism MAP00530 Aminosugars metabolism GenMAPP 8.325E-3 1.873E-2
9.105E-2
5.994E-1
 1 13
32 SMP00043 Galactose Metabolism SMPDB 8.325E-3 1.873E-2
9.105E-2
5.994E-1
 1 13
33 PW:0000045 pentose phosphate Pathway Ontology 8.963E-3 1.898E-2
9.226E-2
6.453E-1
 1 14
34 SMP00031 Pentose Phosphate Pathway SMPDB 8.963E-3 1.898E-2
9.226E-2
6.453E-1
 1 14
35 1269962 Glycogen synthesis BioSystems: REACTOME 9.601E-3 1.975E-2
9.600E-2
6.913E-1
 1 15
36 1270212 Methylation BioSystems: REACTOME 1.024E-2 2.008E-2
9.759E-2
7.371E-1
 1 16
37 1270010 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 1.062E-2 2.008E-2
9.759E-2
7.649E-1
 2 253
38 1269963 Glycogen breakdown (glycogenolysis) BioSystems: REACTOME 1.087E-2 2.008E-2
9.759E-2
7.830E-1
 1 17
39 MAP00030 Pentose phosphate pathway MAP00030 Pentose phosphate GenMAPP 1.087E-2 2.008E-2
9.759E-2
7.830E-1
 1 17
40 PW:0000532 glycogen biosynthetic Pathway Ontology 1.151E-2 2.072E-2
1.007E-1
8.288E-1
 1 18
41 SMP00128 Gluconeogenesis SMPDB 1.215E-2 2.082E-2
1.012E-1
8.746E-1
 1 19
42 SMP00058 Starch and Sucrose Metabolism SMPDB 1.215E-2 2.082E-2
1.012E-1
8.746E-1
 1 19
43 MAP00640 Propanoate metabolism MAP00640 Propanoate metabolism GenMAPP 1.278E-2 2.140E-2
1.040E-1
9.204E-1
 1 20
44 PW:0000140 pathway of folate cycle/metabolism Pathway Ontology 1.342E-2 2.147E-2
1.044E-1
9.661E-1
 1 21
45 PW:0000151 starch and sucrose metabolic Pathway Ontology 1.342E-2 2.147E-2
1.044E-1
9.661E-1
 1 21
46 MAP00500 Starch and sucrose metabolism MAP00500 Starch and sucrose metabolism GenMAPP 1.405E-2 2.200E-2
1.069E-1
1.000E0
 1 22
47 MAP00052 Galactose metabolism MAP00052 Galactose metabolism GenMAPP 1.532E-2 2.298E-2
1.117E-1
1.000E0
 1 24
48 PW:0000534 glycogen degradation Pathway Ontology 1.532E-2 2.298E-2
1.117E-1
1.000E0
 1 24
49 PW:0000048 methionine cycle/metabolic Pathway Ontology 1.596E-2 2.345E-2
1.140E-1
1.000E0
 1 25
50 MAP00280 Valine leucine and isoleucine degradation MAP00280 Valine leucine and isoleucine degradation GenMAPP 1.659E-2 2.389E-2
1.161E-1
1.000E0
 1 26
Show 45 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 638 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20301409 Isolated Methylmalonic Acidemia Pubmed 3.948E-15 2.519E-12 1.772E-11 2.519E-12 4 5
2 28497574 Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria. Pubmed 6.031E-12 7.696E-10 5.415E-9 3.848E-9 3 3
3 17597648 Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB). Pubmed 6.031E-12 7.696E-10 5.415E-9 3.848E-9 3 3
4 17957493 Methylmalonic acidaemia: examination of genotype and biochemical data in 32 patients belonging to mut, cblA or cblB complementation group. Pubmed 6.031E-12 7.696E-10 5.415E-9 3.848E-9 3 3
5 23022071 The methylmalonic aciduria related genes, Mmaa, Mmab, and Mut, are broadly expressed in placental and embryonic tissues during mouse organogenesis. Pubmed 6.031E-12 7.696E-10 5.415E-9 3.848E-9 3 3
6 20301503 Disorders of Intracellular Cobalamin Metabolism Pubmed 7.233E-10 7.691E-8 5.412E-7 4.615E-7 3 10
7 20301334 Dystonia Overview Pubmed 1.179E-9 1.075E-7 7.561E-7 7.522E-7 4 79
8 15347655 Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
9 16641088 Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
10 23415655 The C-terminal domain of CblD interacts with CblC and influences intracellular cobalamin partitioning. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
11 21604717 Loss of allostery and coenzyme B12 delivery by a pathogenic mutation in adenosyltransferase. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
12 23270877 Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
13 17410422 Novel mutations found in two genes of thai patients with isolated methylmalonic acidemia. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
14 21138732 Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
15 15781192 Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
16 21536470 Expression of Mmachc and Mmadhc during mouse organogenesis. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
17 22832074 Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
18 26483544 Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
19 25982642 Biochemical, molecular and outcome analysis of eight chinese asymptomatic individuals with methyl malonic acidemia detected through newborn screening. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
20 20876572 Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
21 21071249 Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin Bâ??â?? metabolism. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
22 28943303 Human MMAA induces the release of inactive cofactor and restores methylmalonyl-CoA mutase activity through their complex formation. Pubmed 3.839E-8 1.113E-6 7.834E-6 2.449E-5 2 2
23 20466634 [Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women]. Pubmed 3.838E-7 1.065E-5 7.491E-5 2.449E-4 2 5
24 20852008 Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer. Pubmed 2.531E-6 6.729E-5 4.735E-4 1.615E-3 2 12
25 23824729 Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Pubmed 7.281E-6 1.858E-4 1.307E-3 4.645E-3 2 20
26 24261678 Methionine synthase reductase A66G polymorphism and leukemia risk: evidence from published studies. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
27 18515090 His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
28 18245139 The adolescent and adult form of cobalamin C disease: clinical and molecular spectrum. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
29 9501215 Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
30 26972339 Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
31 17431913 Late-onset cobalamin-C disorder: a challenging diagnosis. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
32 27383490 Report - Report on the heterozygosis mutations of c.567dupT, p.(Ile190Tyrfs*13) of MMACHC gene in 1 Child patient with methylmalonic academia. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
33 23898205 Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
34 17087642 MTRR 66A>G polymorphism in relation to congenital heart defects. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
35 14622275 Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
36 21472912 ELDOR spectroscopy reveals that energy landscapes in human methionine synthase reductase are extensively remodelled following ligand and partner protein binding. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
37 10874303 The spectrum of mutations, including four novel ones, in the thiamine-responsive megaloblastic anemia gene SLC19A2 of eight families. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
38 26563984 Clinical presentation, gene analysis and outcomes in young patients with early-treated combined methylmalonic acidemia and homocysteinemia (cblC type) in Shandong province, China. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
39 18385497 Gene identification for the cblD defect of vitamin B12 metabolism. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
40 20631720 Mutation spectrum of MMACHC in Chinese patients with combined methylmalonic aciduria and homocystinuria. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
41 2907507 Linkage relationships of the human methylmalonyl CoA mutase to the HLA and D6S4 loci on chromosome 6. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
42 18251506 Functional characterization and mutation analysis of human ATP:Cob(I)alamin adenosyltransferase. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
43 19447654 Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
44 25707023 Thiamine responsive megaloblastic anemia syndrome: a novel homozygous SLC19A2 gene mutation identified. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
45 1980486 Structure of the human methylmalonyl-CoA mutase (MUT) locus. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
46 27060300 [Identification of two novel mutations of MUT gene in a Chinese family affected with isolated methylmalonic acidemia]. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
47 22179537 Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
48 22792386 Mouse models for methylmalonic aciduria. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
49 6124211 Purification and properties of methylmalonyl coenzyme A mutase from human liver. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
50 20556797 Functional and structural analysis of five mutations identified in methylmalonic aciduria cblB type. Pubmed 2.095E-4 5.663E-4 3.984E-3
1.336E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 128 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MMAA MMAA interactions 5.360E-7 6.860E-5 3.727E-4 6.860E-5 2 3
2 int:MMACHC MMACHC interactions 1.786E-6 1.143E-4 6.209E-4 2.286E-4 2 5
3 int:MTRR MTRR interactions 1.177E-5 3.766E-4 2.046E-3 1.506E-3 2 12
4 int:MMUT MMUT interactions 1.177E-5 3.766E-4 2.046E-3 1.506E-3 2 12
5 int:MMADHC MMADHC interactions 2.422E-5 5.167E-4 2.807E-3 3.100E-3 2 17
6 int:MMAB MMAB interactions 2.422E-5 5.167E-4 2.807E-3 3.100E-3 2 17
7 int:OXLD1 OXLD1 interactions 2.079E-4 3.802E-3 2.066E-2 2.661E-2 2 49
8 int:FH FH interactions 9.175E-4 1.468E-2
7.976E-2
1.174E-1
 2 103
9 int:PMFBP1 PMFBP1 interactions 1.807E-3 2.569E-2
1.396E-1
2.312E-1
 1 4
10 int:KIF12 KIF12 interactions 2.258E-3 2.890E-2
1.570E-1
2.890E-1
 1 5
11 int:BPHL BPHL interactions 3.610E-3 3.549E-2
1.928E-1
4.621E-1
 1 8
12 int:OXNAD1 OXNAD1 interactions 3.610E-3 3.549E-2
1.928E-1
4.621E-1
 1 8
13 int:P2RY1 P2RY1 interactions 4.961E-3 3.549E-2
1.928E-1
6.350E-1
 1 11
14 int:SLC5A5 SLC5A5 interactions 4.961E-3 3.549E-2
1.928E-1
6.350E-1
 1 11
15 int:MRPL58 MRPL58 interactions 5.341E-3 3.549E-2
1.928E-1
6.836E-1
 2 252
16 int:GRPEL2 GRPEL2 interactions 5.411E-3 3.549E-2
1.928E-1
6.926E-1
 1 12
17 int:FAH FAH interactions 5.411E-3 3.549E-2
1.928E-1
6.926E-1
 1 12
18 int:NUDT6 NUDT6 interactions 5.411E-3 3.549E-2
1.928E-1
6.926E-1
 1 12
19 int:C9orf24 C9orf24 interactions 5.861E-3 3.549E-2
1.928E-1
7.502E-1
 1 13
20 int:ABHD11 ABHD11 interactions 5.861E-3 3.549E-2
1.928E-1
7.502E-1
 1 13
21 int:DNASE1L2 DNASE1L2 interactions 5.861E-3 3.549E-2
1.928E-1
7.502E-1
 1 13
22 int:ARHGEF26 ARHGEF26 interactions 6.310E-3 3.549E-2
1.928E-1
8.077E-1
 1 14
23 int:PGM2 PGM2 interactions 6.760E-3 3.549E-2
1.928E-1
8.653E-1
 1 15
24 int:ECHDC2 ECHDC2 interactions 6.760E-3 3.549E-2
1.928E-1
8.653E-1
 1 15
25 int:KYAT3 KYAT3 interactions 7.209E-3 3.549E-2
1.928E-1
9.228E-1
 1 16
26 int:GALK2 GALK2 interactions 7.209E-3 3.549E-2
1.928E-1
9.228E-1
 1 16
27 int:L3HYPDH L3HYPDH interactions 8.107E-3 3.843E-2
2.088E-1
1.000E0
 1 18
28 int:PGM3 PGM3 interactions 9.004E-3 3.960E-2
2.152E-1
1.000E0
 1 20
29 int:TEKT2 TEKT2 interactions 9.004E-3 3.960E-2
2.152E-1
1.000E0
 1 20
30 int:CCDC69 CCDC69 interactions 9.901E-3 3.960E-2
2.152E-1
1.000E0
 1 22
31 int:ZFYVE27 ZFYVE27 interactions 9.901E-3 3.960E-2
2.152E-1
1.000E0
 1 22
32 int:CFH CFH interactions 9.901E-3 3.960E-2
2.152E-1
1.000E0
 1 22
33 int:LTA4H LTA4H interactions 1.169E-2 4.279E-2
2.325E-1
1.000E0
 1 26
34 int:NIT2 NIT2 interactions 1.214E-2 4.279E-2
2.325E-1
1.000E0
 1 27
35 int:RASL10B RASL10B interactions 1.259E-2 4.279E-2
2.325E-1
1.000E0
 1 28
36 int:HADH HADH interactions 1.259E-2 4.279E-2
2.325E-1
1.000E0
 1 28
37 int:S100A1 S100A1 interactions 1.303E-2 4.279E-2
2.325E-1
1.000E0
 1 29
38 int:TMEM184A TMEM184A interactions 1.348E-2 4.279E-2
2.325E-1
1.000E0
 1 30
39 int:SLC19A2 SLC19A2 interactions 1.393E-2 4.279E-2
2.325E-1
1.000E0
 1 31
40 int:GPD1L GPD1L interactions 1.393E-2 4.279E-2
2.325E-1
1.000E0
 1 31
41 int:SLC9A6 SLC9A6 interactions 1.437E-2 4.279E-2
2.325E-1
1.000E0
 1 32
42 int:CD27 CD27 interactions 1.482E-2 4.279E-2
2.325E-1
1.000E0
 1 33
43 int:TRMT61B TRMT61B interactions 1.482E-2 4.279E-2
2.325E-1
1.000E0
 1 33
44 int:B4GALT3 B4GALT3 interactions 1.526E-2 4.279E-2
2.325E-1
1.000E0
 1 34
45 int:MRRF MRRF interactions 1.526E-2 4.279E-2
2.325E-1
1.000E0
 1 34
46 int:ABAT ABAT interactions 1.571E-2 4.279E-2
2.325E-1
1.000E0
 1 35
47 int:AAMP AAMP interactions 1.571E-2 4.279E-2
2.325E-1
1.000E0
 1 35
48 int:GRHPR GRHPR interactions 1.705E-2 4.546E-2
2.470E-1
1.000E0
 1 38
49 int:MRPS24 MRPS24 interactions 1.749E-2 4.547E-2
2.470E-1
1.000E0
 1 39
50 int:AGTR1 AGTR1 interactions 1.838E-2 4.547E-2
2.470E-1
1.000E0
 1 41
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q23.2 2q23.2 1.384E-3 9.945E-3 2.703E-2 1.107E-2 1 6
2 5p15.31 5p15.31 2.997E-3 9.945E-3 2.703E-2 2.397E-2 1 13
3 1p31 1p31 5.527E-3 9.945E-3 2.703E-2 4.421E-2 1 24
4 12q24 12q24 5.756E-3 9.945E-3 2.703E-2 4.605E-2 1 25
5 4q31.21 4q31.21 6.215E-3 9.945E-3 2.703E-2 4.972E-2 1 27
6 6p12.3 6p12.3 8.509E-3 1.135E-2 3.083E-2
6.807E-2
 1 37
7 1q23.3 1q23.3 1.171E-2 1.308E-2 3.555E-2
9.370E-2
 1 51
8 1p34.1 1p34.1 1.308E-2 1.308E-2 3.555E-2
1.047E-1
 1 57
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 8 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 1 input genes in category / 1 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 752 Solute carriers genenames.org 2.171E-2 2.171E-2 2.171E-2 2.171E-2 1 395

13: Coexpression [Display Chart] 8 input genes in category / 581 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6160 Genes down-regulated in D10.G4.1 T cell line (3h): control versus treated with NMU [GeneID=10874]. MSigDB C7: Immunologic Signatures (v6.0) 3.336E-7 1.938E-4 1.345E-3 1.938E-4 4 195
2 M18491 Genes up-regulated by ESRRA [GeneID=2101] only. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.462E-4 3.896E-2
2.705E-1
1.430E-1
 3 388
3 M2221 Genes up-regulated in K562 cells (lymphoblast) by MYC [GeneID=4609] in the presence of CKN1B [GeneID=1027]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.596E-4 3.896E-2
2.705E-1
2.089E-1
 2 84
4 M2133 Genes up-regulated by hypoxia in TRAMP-C cells (prostatic cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.939E-4 3.896E-2
2.705E-1
5.774E-1
 2 140
5 M8901 Down-regulated genes from the 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.125E-3 3.896E-2
2.705E-1
6.533E-1
 2 149
6 M19990 Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 6h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.409E-3 3.896E-2
2.705E-1
8.188E-1
 2 167
7 M5681 Genes up-regulated in apoptotic tissues (neuroepithelium) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.563E-3 3.896E-2
2.705E-1
9.083E-1
 2 176
8 M7564 Genes up-regulated in CD11b Spleen from BALBc mouse versus CD11b BoneMarrow from BALBc mouse incubated with GMCSF and GCSF. MSigDB C7: Immunologic Signatures (v6.0) 1.799E-3 3.896E-2
2.705E-1
1.000E0
 2 189
9 M9813 Genes down-regulated in at day 0 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4-KO. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.896E-2
2.705E-1
1.000E0
 2 198
10 M7222 Genes down-regulated in T cells: control (0h) versus IL21 [GeneID=59067] treatment for 1h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.896E-2
2.705E-1
1.000E0
 2 199
11 M4036 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.896E-2
2.705E-1
1.000E0
 2 199
12 M4049 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.896E-2
2.705E-1
1.000E0
 2 199
13 M6098 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus IL-12 (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.896E-2
2.705E-1
1.000E0
 2 199
14 M4030 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
15 M7960 Genes down-regulated in macrophages (12h): control versus IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
16 M3413 Genes up-regulated in comparison of microglia cells 1 h after stimulation with IFNG [GeneID=3458] versus microglia cells 24 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
17 M4402 Genes up-regulated in comparison of naive CD8 T cells versus naive CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
18 M9505 Genes up-regulated in CD8 T cells: naïve versus effectors at day 8 chronic infection with LCMV-clone 13. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
19 M3486 Genes down-regulated in naive CD4 [GeneID=920] T cells from cord blood versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
20 M9366 Genes up-regulated in day 7 memory B cells versus day 7 plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
21 M3929 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
22 M3917 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
23 M7692 Genes down-regulated in mouse embryonic fibroblasts (MEF): wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
24 M9738 Genes down-regulated in CD4 [GeneID=920] SMARTA T cells: naïve versus memory follicular helper (Tfh). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
25 M3841 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
26 M7808 Genes up-regulated in monocyte-derived dendritic cells: control versus HIV and SIV infection. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
27 M3507 Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 240 min. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
28 M7757 Genes down-regulated in macrophages: untreated versus 12h after M. bovis BCG infection. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
29 M5093 Genes up-regulated in comparison of memory CD8 T cells treated with IL7 [GeneID=3574] versus those treated with IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
30 M7418 Genes down-regulated in neuron cell line treated with interferon alpha for 12h: immature versus mature. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.896E-2
2.705E-1
1.000E0
 2 200
31 M1570 Genes up-regulated in non-apoptotic tissues (fetal liver) after MDM4 [GeneID=4194] knockout. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.581E-3 4.837E-2
3.358E-1
1.000E0
 2 227
Show 26 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 183 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 11 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 8 input genes in category / 220 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1298:mirSVR highEffct hsa-miR-1298:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.742E-4 3.511E-2
2.097E-1
6.033E-2
 2 228
2 hsa-miR-95:mirSVR lowEffct hsa-miR-95:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.798E-4 3.511E-2
2.097E-1
1.496E-1
 2 360
3 hsa-miR-125b-1*:mirSVR lowEffct hsa-miR-125b-1*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.449E-4 3.511E-2
2.097E-1
1.639E-1
 2 377
4 hsa-miR-423-3p:mirSVR lowEffct hsa-miR-423-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.294E-4 3.511E-2
2.097E-1
1.825E-1
 2 398
5 hsa-miR-328:mirSVR highEffct hsa-miR-328:mirSVR conserved highEffect-0.5 MicroRNA.org 8.501E-4 3.511E-2
2.097E-1
1.870E-1
 2 403
6 hsa-miR-186-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.076E-3 3.511E-2
2.097E-1
2.368E-1
 2 454
7 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 1.216E-3 3.511E-2
2.097E-1
2.676E-1
 2 483
8 hsa-miR-3147:mirSVR highEffct hsa-miR-3147:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.277E-3 3.511E-2
2.097E-1
2.809E-1
 2 495
9 hsa-miR-718:Functional MTI Functional MTI miRTarbase 1.660E-3 4.058E-2
2.424E-1
3.652E-1
 1 15
10 hsa-miR-1468-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.881E-3 4.138E-2
2.472E-1
4.138E-1
 1 17
11 hsa-miR-6880-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.434E-3 4.433E-2
2.648E-1
5.354E-1
 1 22
12 hsa-miR-6831-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.980E-3 4.433E-2
2.648E-1
8.756E-1
 1 36
13 hsa-miR-6808-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.421E-3 4.433E-2
2.648E-1
9.727E-1
 1 40
14 hsa-miR-3655:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 4.433E-2
2.648E-1
1.000E0
 1 42
15 hsa-miR-7153-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.524E-3 4.433E-2
2.648E-1
1.000E0
 1 50
16 hsa-miR-1322:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.854E-3 4.433E-2
2.648E-1
1.000E0
 1 53
17 hsa-miR-758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.405E-3 4.433E-2
2.648E-1
1.000E0
 1 58
18 hsa-miR-320e:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.736E-3 4.433E-2
2.648E-1
1.000E0
 1 61
19 hsa-miR-6894-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 4.433E-2
2.648E-1
1.000E0
 1 63
20 hsa-miR-5088-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.286E-3 4.433E-2
2.648E-1
1.000E0
 1 66
21 hsa-miR-3064-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.616E-3 4.433E-2
2.648E-1
1.000E0
 1 69
22 hsa-miR-4721:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.946E-3 4.433E-2
2.648E-1
1.000E0
 1 72
23 hsa-miR-411-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.056E-3 4.433E-2
2.648E-1
1.000E0
 1 73
24 hsa-miR-6884-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.056E-3 4.433E-2
2.648E-1
1.000E0
 1 73
25 hsa-miR-4763-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.166E-3 4.433E-2
2.648E-1
1.000E0
 1 74
26 hsa-miR-1911-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.276E-3 4.433E-2
2.648E-1
1.000E0
 1 75
27 hsa-miR-6852-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.386E-3 4.433E-2
2.648E-1
1.000E0
 1 76
28 hsa-miR-380-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.496E-3 4.433E-2
2.648E-1
1.000E0
 1 77
29 hsa-miR-633:Functional MTI Functional MTI miRTarbase 8.935E-3 4.433E-2
2.648E-1
1.000E0
 1 81
30 hsa-miR-3909:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.935E-3 4.433E-2
2.648E-1
1.000E0
 1 81
31 hsa-miR-3130-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.155E-3 4.433E-2
2.648E-1
1.000E0
 1 83
32 hsa-miR-4666a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.265E-3 4.433E-2
2.648E-1
1.000E0
 1 84
33 hsa-miR-379-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.265E-3 4.433E-2
2.648E-1
1.000E0
 1 84
34 hsa-miR-4297:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.375E-3 4.433E-2
2.648E-1
1.000E0
 1 85
35 hsa-miR-5581-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.485E-3 4.433E-2
2.648E-1
1.000E0
 1 86
36 TCTGATA,MIR-361:MSigDB TCTGATA,MIR-361:MSigDB MSigDB 9.594E-3 4.433E-2
2.648E-1
1.000E0
 1 87
37 hsa-miR-1272:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.704E-3 4.433E-2
2.648E-1
1.000E0
 1 88
38 hsa-miR-4711-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.814E-3 4.433E-2
2.648E-1
1.000E0
 1 89
39 hsa-miR-2052:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.003E-2 4.433E-2
2.648E-1
1.000E0
 1 91
40 hsa-miR-1281:mirSVR highEffct hsa-miR-1281:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.014E-2 4.433E-2
2.648E-1
1.000E0
 1 92
41 hsa-miR-586:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.025E-2 4.433E-2
2.648E-1
1.000E0
 1 93
42 hsa-miR-374b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.069E-2 4.433E-2
2.648E-1
1.000E0
 1 97
43 hsa-miR-409-5p:TargetScan hsa-miR-409-5p TargetScan 1.069E-2 4.433E-2
2.648E-1
1.000E0
 1 97
44 hsa-miR-448:Functional MTI Functional MTI miRTarbase 1.091E-2 4.433E-2
2.648E-1
1.000E0
 1 99
45 hsa-miR-6507-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.168E-2 4.433E-2
2.648E-1
1.000E0
 1 106
46 hsa-miR-19b-2-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.168E-2 4.433E-2
2.648E-1
1.000E0
 1 106
47 hsa-miR-3174:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.179E-2 4.433E-2
2.648E-1
1.000E0
 1 107
48 hsa-miR-4776-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.201E-2 4.433E-2
2.648E-1
1.000E0
 1 109
49 hsa-miR-19a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.201E-2 4.433E-2
2.648E-1
1.000E0
 1 109
50 hsa-miR-6823-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.223E-2 4.433E-2
2.648E-1
1.000E0
 1 111
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 1321 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 DB00200 Hydroxocobalamin Drug Bank 1.362E-16 1.799E-13 1.397E-12 1.799E-13 5 9
2 DB00115 Cyanocobalamin Drug Bank 9.258E-14 6.115E-11 4.748E-10 1.223E-10 4 6
3 CID000424379 adenosylcobalamin Stitch 3.087E-12 1.359E-9 1.055E-8 4.078E-9 5 53
4 CID000000146 5-methyltetrahydrofolate Stitch 3.516E-11 1.161E-8 9.015E-8 4.645E-8 5 85
5 CID003958805 AC1NBT2J Stitch 2.211E-10 5.843E-8 4.536E-7 2.921E-7 4 32
6 CID004479097 vitamin B12b Stitch 8.334E-10 1.835E-7 1.425E-6 1.101E-6 4 44
7 CID006436232 mecobalamin Stitch 1.533E-9 2.892E-7 2.246E-6 2.025E-6 4 51
8 CID000002823 AC1L1EJT Stitch 3.890E-9 6.423E-7 4.987E-6 5.139E-6 4 64
9 CID000000487 methylmalonic acid Stitch 4.983E-9 7.314E-7 5.678E-6 6.583E-6 4 68
10 CID000000613 methylmalonyl-CoA Stitch 9.179E-9 1.213E-6 9.414E-6 1.213E-5 4 79
11 CID000061492 cobalt-60 Stitch 7.595E-8 9.121E-6 7.081E-5 1.003E-4 5 390
12 CID000002891 CAS 68-19-9 Stitch 1.069E-7 1.177E-5 9.139E-5 1.413E-4 4 145
13 CID000001111 succinyl-coenzyme A Stitch 1.841E-7 1.871E-5 1.453E-4 2.432E-4 4 166
14 CID000000247 betaine Stitch 3.885E-7 3.666E-5 2.846E-4 5.132E-4 4 200
15 CID000000778 homocysteine Stitch 1.213E-6 1.069E-4 8.297E-4 1.603E-3 4 266
16 CID000010010 homocystine Stitch 2.465E-6 2.035E-4 1.580E-3 3.257E-3 3 82
17 CID000000834 cystathionine Stitch 5.502E-6 4.276E-4 3.320E-3 7.269E-3 3 107
18 CID000014974 Ostreogrycin B Stitch 1.285E-5 9.430E-4 7.321E-3 1.697E-2 2 16
19 CID000001033 n-propionyl-CoA Stitch 2.055E-5 1.429E-3 1.109E-2 2.715E-2 3 166
20 CID005462220 AC1NUW81 Stitch 2.471E-5 1.632E-3 1.267E-2 3.264E-2 2 22
21 1802 DN Panthenol (D) [81-13-0]; Down 200; 19.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.480E-5 2.189E-3 1.699E-2 4.597E-2 3 198
22 CID000003405 folate polyglutamate Stitch 3.860E-5 2.317E-3 1.799E-2
5.098E-2
 3 205
23 CID000656967 WaI Stitch 5.296E-5 3.042E-3 2.362E-2
6.996E-2
 2 32
24 CID000000476 phosphomevalonate Stitch 5.637E-5 3.103E-3 2.409E-2
7.447E-2
 2 33
25 CID000001032 propionate Stitch 8.007E-5 4.231E-3 3.285E-2
1.058E-1
 3 262
26 CID006438343 corrinoid Stitch 8.742E-5 4.442E-3 3.448E-2
1.155E-1
 2 41
27 CID000000136 5,10CH=THF Stitch 9.178E-5 4.490E-3 3.486E-2
1.212E-1
 2 42
28 CID000000142 NSC89222 Stitch 1.151E-4 5.432E-3 4.217E-2
1.521E-1
 2 47
29 CID000007852 3-aminopropyl Stitch 1.252E-4 5.703E-3 4.428E-2
1.654E-1
 2 49
30 CID000006337 ethyl chloride Stitch 1.357E-4 5.975E-3 4.639E-2
1.793E-1
 2 51
31 CID000447083 S)-ACPA Stitch 1.522E-4 6.486E-3
5.036E-2
2.011E-1
 2 54
32 CID000000808 AC1L1A2K Stitch 2.277E-4 8.730E-3
6.778E-2
3.008E-1
 2 66
33 CID000027982 ethephon Stitch 2.346E-4 8.730E-3
6.778E-2
3.100E-1
 2 67
34 CID000002681 cetyltrimethylammonium bromide Stitch 2.417E-4 8.730E-3
6.778E-2
3.193E-1
 2 68
35 CID000000884 N5,N10-methylene tetrahydrofolic acid Stitch 2.941E-4 8.730E-3
6.778E-2
3.885E-1
 2 75
36 CID005229475 AC1NQVOU Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
37 CID000012860 triisopropylbenzene Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
38 CID000609819 4-hydroxymethyl-7-methoxycoumarin Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
39 CID005229473 AC1NQVOR Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
40 CID003035014 L-644,711 Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
41 CID000449560 Succinyl(carbadethia)-coenzyme A Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
42 CID000188941 caged 8-Br-cAMP Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
43 ctd:C015357 methylmalonyl-coenzyme A CTD 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
44 CID003082312 monensin B Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
45 CID003083499 caged 8-Br-cGMP Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
46 CID006432049 Sesn Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
47 CID000098644 methyl 2-acetamidoacrylate Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
48 CID000010890 amyl-butyrate Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
49 CID012827211 2-[2-[2-[2-[2-[2-(2-hydroxypropoxy)propoxy]propoxy]propoxy]propoxy]propoxy]propan-1-ol Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
50 CID000128944 4PTIQ Stitch 3.502E-4 8.730E-3
6.778E-2
4.627E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 250 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1855119 Methylmalonic aciduria DisGeNET Curated 5.145E-14 1.286E-11 7.847E-11 1.286E-11 5 18
2 C0268583 Methylmalonic acidemia DisGeNET Curated 4.841E-13 6.051E-11 3.692E-10 1.210E-10 5 27
3 C0002888 Anemia, Megaloblastic DisGeNET Curated 1.177E-10 9.809E-9 5.984E-8 2.943E-8 4 20
4 C0023380 Lethargy DisGeNET Curated 1.835E-10 1.128E-8 6.881E-8 4.588E-8 5 84
5 C1848555 Hypomethioninemia DisGeNET Curated 3.158E-10 1.128E-8 6.881E-8 7.895E-8 3 4
6 C1848580 Decreased methionine synthase activity DisGeNET Curated 3.158E-10 1.128E-8 6.881E-8 7.895E-8 3 4
7 C4021736 Decreased methylcobalamin DisGeNET Curated 3.158E-10 1.128E-8 6.881E-8 7.895E-8 3 4
8 C0019880 Homocystinuria DisGeNET Curated 3.628E-10 1.134E-8 6.916E-8 9.069E-8 4 26
9 C3806347 Hyperhomocystinemia DisGeNET Curated 1.578E-9 4.384E-8 2.675E-7 3.946E-7 3 6
10 C0276096 Mastitis-metritis-agalactia syndrome DisGeNET BeFree 2.867E-8 7.168E-7 4.373E-6 7.168E-6 3 14
11 C0003123 Anorexia DisGeNET Curated 9.377E-8 2.131E-6 1.300E-5 2.344E-5 4 100
12 C1272348 Disorder of vitamin B12 DisGeNET BeFree 2.133E-7 3.808E-6 2.323E-5 5.332E-5 2 2
13 C1848579 Decreased activity of methylmalonyl-CoA mutase (MUT, 609058) DisGeNET Curated 2.133E-7 3.808E-6 2.323E-5 5.332E-5 2 2
14 C0342720 Adenosylcobalamin synthesis defect DisGeNET BeFree 2.133E-7 3.808E-6 2.323E-5 5.332E-5 2 2
15 C1848556 Decreased adenosylcobalamin (AdoCbl) DisGeNET Curated 6.396E-7 9.994E-6 6.097E-5 1.599E-4 2 3
16 C0238801 Bone marrow megaloblastic (finding) DisGeNET Curated 6.396E-7 9.994E-6 6.097E-5 1.599E-4 2 3
17 C0030232 Pallor DisGeNET Curated 8.345E-7 1.227E-5 7.486E-5 2.086E-4 3 41
18 C0028738 Nystagmus DisGeNET Curated 1.149E-5 1.595E-4 9.732E-4 2.871E-3 4 333
19 C0231246 Failure to gain weight DisGeNET Curated 1.686E-5 2.194E-4 1.338E-3 4.215E-3 4 367
20 C0392386 Decreased platelet count DisGeNET Curated 1.755E-5 2.194E-4 1.338E-3 4.387E-3 3 112
21 C0042847 Vitamin B 12 Deficiency DisGeNET Curated 1.935E-5 2.267E-4 1.383E-3 4.837E-3 2 14
22 C2315100 Pediatric failure to thrive DisGeNET Curated 1.995E-5 2.267E-4 1.383E-3 4.986E-3 4 383
23 C1848924 Infantile onset DisGeNET Curated 1.659E-4 1.803E-3 1.100E-2 4.147E-2 3 238
24 C0235946 Cerebral atrophy DisGeNET Curated 1.964E-4 2.046E-3 1.248E-2 4.911E-2 3 252
25 C0040034 Thrombocytopenia DisGeNET Curated 3.283E-4 2.468E-3 1.506E-2
8.208E-2
 3 300
26 C0025521 Inborn Errors of Metabolism DisGeNET Curated 4.640E-4 2.468E-3 1.506E-2
1.160E-1
 2 67
27 C4025706 Abnormality of the globus pallidus DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
28 OMIN:277400 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblC TYPE OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
29 cv:C1855102 Methylmalonic aciduria cblB type Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
30 cv:C1855109 Methylmalonic aciduria cblA type Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
31 C1855109 Methylmalonic aciduria cblA type DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
32 C0268618 Cystathioninemia DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
33 cv:C1848561 Methylmalonic acidemia with homocystinuria Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
34 OMIN:251100 METHYLMALONIC ACIDURIA, cblA TYPE OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
35 cv:C3554056 Congenital disorder of glycosylation type 1t Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
36 cv:C1855114 Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
37 cv:C1848552 Methylmalonic acidemia with homocystinuria cblD Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
38 C1856057 Homocystinuria-Megaloblastic Anemia due to Defect in Cobalamin Metabolism, CblE Complementation Type DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
39 OMIN:236270 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, cblE COMPLEMENTATION TYPE OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
40 C1848552 Methylmalonic Aciduria and Homocystinuria, CblD Type DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
41 OMIN:251110 METHYLMALONIC ACIDURIA, cblB TYPE OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
42 cv:C1856057 Homocystinuria-Megaloblastic anemia due to defect in cobalamin metabolism, cblE complementation type Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
43 C1855114 Methylmalonic Aciduria due to Methylmalonyl-CoA Mutase Deficiency DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
44 OMIN:612934 GLYCOGEN STORAGE DISEASE XIV; GSD14 OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
45 cv:C0342287 Megaloblastic anemia, thiamine-responsive, with diabetes mellitus and sensorineural deafness Clinical Variations 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
46 OMIN:277410 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA, cblD TYPE OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
47 OMIN:249270 THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA SYNDROME; TRMA OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
48 OMIN:251000 METHYLMALONIC ACIDURIA DUE TO METHYLMALONYL-CoA MUTASE DEFICIENCY OMIM 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
49 C2752015 Glycogen Storage Disease XIV DisGeNET Curated 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
50 C1263739 Disorder of organic acid metabolism DisGeNET BeFree 4.937E-4 2.468E-3 1.506E-2
1.234E-1
 1 1
Show 45 more annotations